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Sparse Data Reconstruction, Missing Value and Multiple Imputation through Matrix Factorization 稀疏数据重构、缺失值与矩阵分解多重插值
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-10-22 DOI: 10.1177/00811750221125799
Nandana Sengupta, Madeleine Udell, N. Srebro, James Evans
Social science approaches to missing values predict avoided, unrequested, or lost information from dense data sets, typically surveys. The authors propose a matrix factorization approach to missing data imputation that (1) identifies underlying factors to model similarities across respondents and responses and (2) regularizes across factors to reduce their overinfluence for optimal data reconstruction. This approach may enable social scientists to draw new conclusions from sparse data sets with a large number of features, for example, historical or archival sources, online surveys with high attrition rates, or data sets created from Web scraping, which confound traditional imputation techniques. The authors introduce matrix factorization techniques and detail their probabilistic interpretation, and they demonstrate these techniques’ consistency with Rubin’s multiple imputation framework. The authors show via simulations using artificial data and data from real-world subsets of the General Social Survey and National Longitudinal Study of Youth cases for which matrix factorization techniques may be preferred. These findings recommend the use of matrix factorization for data reconstruction in several settings, particularly when data are Boolean and categorical and when large proportions of the data are missing.
缺失值的社会科学方法预测了密集数据集(通常是调查)中被回避、未被请求或丢失的信息。作者提出了一种缺失数据插补的矩阵分解方法,该方法(1)识别潜在因素,以模拟受访者和回答之间的相似性,(2)对各因素进行正则化,以减少它们对最佳数据重建的过度影响。这种方法可能使社会科学家能够从具有大量特征的稀疏数据集中得出新的结论,例如,历史或档案来源、流失率高的在线调查,或通过网络抓取创建的数据集,这些数据集混淆了传统的插补技术。作者介绍了矩阵分解技术,并详细介绍了它们的概率解释,并证明了这些技术与鲁宾的多重插补框架的一致性。作者通过使用人工数据和来自一般社会调查和全国青年纵向研究的真实世界子集的数据进行模拟,表明矩阵分解技术可能是首选的。这些发现建议在几种情况下使用矩阵分解进行数据重建,特别是当数据是布尔和分类的,以及当大量数据丢失时。
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引用次数: 3
Hyperscanning and the Future of Neurosociology 超扫描与神经社会学的未来
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-10-15 DOI: 10.1177/00811750221128790
W. TenHouten, L. Schussel, Maria Gritsch, C. D. Kaplan
Because all aspects of social life have a mental component, sociology’s focus is not society alone but mind and society. Insofar as mind is an emergent level of brainwork, the description and measurement of mindwork amidst social interaction can be accomplished by neurometric measurement methodology. The authors’ topic, hyperscanning, involves the simultaneous recording of either hemodynamic or neuroelectric measurement of brain activity in two (or more) interacting individuals. The authors consider two hyperscanning methods, functional magnetic resonance imaging and electroencephalography (EEG). Although functional magnetic resonance imaging provides excellent spatial resolution of brain-region activation, the temporal resolution of EEG is unmatched. EEG’s low spatial resolution has been overcome by low-resolution electromagnetic tomography. Hyperscanning studies show that interpersonal coordination of action includes mutual entrainment or synchronization of neural dynamics, flow of information between brains, and causal effects of one brain upon another with respect to social-signaling processes involving fairness, reciprocity, trust, competition, cooperation, and leadership.
因为社会生活的各个方面都有心理成分,所以社会学的重点不仅仅是社会,而是心理和社会。由于心理是脑力劳动的一种突现水平,对社会互动中脑力劳动的描述和测量可以通过神经测量方法来完成。作者的主题,超扫描,涉及同时记录两个(或更多)相互作用的个体的血流动力学或神经电测量的大脑活动。作者考虑了两种超扫描方法,功能磁共振成像和脑电图(EEG)。虽然功能磁共振成像提供了良好的脑区激活的空间分辨率,但EEG的时间分辨率是无法比拟的。低分辨率电磁成像技术克服了脑电图的低空间分辨率。超扫描研究表明,行为的人际协调包括神经动力学的相互卷入或同步,大脑之间的信息流,以及一个大脑对另一个大脑在涉及公平、互惠、信任、竞争、合作和领导的社会信号过程中的因果效应。
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引用次数: 2
Data Quality and Recall Bias in Time-Diary Research: The Effects of Prolonged Recall Periods in Self-Administered Online Time-Use Surveys 时间日记研究中的数据质量和回忆偏差:自我管理的在线时间使用调查中长回忆期的影响
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-10-05 DOI: 10.1177/00811750221126499
Petrus te Braak, T. P. van Tienoven, Joeri Minnen, I. Glorieux
Previous research has shown that a prolonged recall period is associated with lower data quality in time-diary research. In these studies, the recall period is roughly estimated on the basis of the period between the assigned diary day and the agreed collection day. Because this is so rudimentary, little is known about the duration of the mean recall period and its consequences for data quality. Recent advances in online methodology now allow a better investigation of the recall period using time stamps. Using a refined indicator, the authors examine the duration of the recall period, to what extent this duration is related to socioeconomic characteristics, and how a prolonged recall period affects data quality. The authors demonstrate that using online time-diary data collected from 8,535 teachers in Belgium, the mean recall period is less than 24 hr for most respondents, although respondents with many time constraints have extended recall periods. Additionally, a prolonged recall period indeed has negative consequences for data quality. Quality deterioration already arises several hours after an activity has been completed, much sooner than previous research has indicated.
先前的研究表明,在时间日记研究中,长时间的回忆与较低的数据质量有关。在这些研究中,回忆期是根据指定的日记日和约定的收集日之间的时间段粗略估计的。因为这是非常初级的,所以对平均召回期的持续时间及其对数据质量的影响知之甚少。在线方法的最新进展现在允许使用时间戳更好地调查召回期。使用一个精细的指标,作者检查了召回期的持续时间,这一持续时间在多大程度上与社会经济特征有关,以及延长的召回期如何影响数据质量。作者证明,使用从比利时8535名教师那里收集的在线时间日记数据,大多数受访者的平均回忆期不到24小时,尽管有许多时间限制的受访者延长了回忆期。此外,长时间的召回确实会对数据质量产生负面影响。在一项活动完成数小时后,质量就已经恶化,比之前的研究表明的要早得多。
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引用次数: 3
Bayesian Multistate Life Table Methods for Large and Complex State Spaces: Development and Illustration of a New Method. 大型复杂状态空间的贝叶斯多状态生命表方法:一种新方法的发展与说明。
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-08-01 DOI: 10.1177/00811750221112398
Scott M Lynch, Emma Zang

Multistate life table methods are an important tool for producing easily understood measures of population health. Most contemporary uses of these methods involve sample data, thus requiring techniques for capturing uncertainty in estimates. In recent decades, several methods have been developed to do so. Among these methods, the Bayesian approach proposed by Lynch and Brown has several unique advantages. However, the approach is limited to estimating years to be spent in only two living states, such as "healthy" and "unhealthy." In this article, the authors extend this method to allow for large state spaces with "quasi-absorbing" states. The authors illustrate the new method and show its advantages using data from the Health and Retirement Study to investigate U.S. regional differences in years of remaining life to be spent with diabetes, chronic conditions, and disabilities. The method works well and yields rich output for reporting and subsequent analyses. The expanded method also should facilitate the use of multi-state life tables to address a wider array of social science research questions.

多态生命表法是产生易于理解的人口健康指标的重要工具。这些方法的大多数当代应用涉及样本数据,因此需要技术来捕捉估计中的不确定性。近几十年来,已经开发了几种方法来做到这一点。在这些方法中,Lynch和Brown提出的贝叶斯方法有几个独特的优点。然而,这种方法仅限于估计在两种生活状态下的寿命,比如“健康”和“不健康”。在本文中,作者扩展了该方法,以允许具有“准吸收”状态的大状态空间。作者用健康和退休研究的数据说明了这种新方法,并展示了它的优势,该研究调查了美国地区在糖尿病、慢性病和残疾患者剩余寿命方面的差异。该方法工作良好,并为报告和后续分析产生丰富的输出。扩展后的方法还应有助于使用多状态生命表来解决更广泛的社会科学研究问题。
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引用次数: 1
A New RCM Approach to Survival Analysis: The Conditional-Incidence-Rate Model 生存分析的RCM新方法:条件发病率模型
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-07-29 DOI: 10.1177/00811750221114857
K. Yamaguchi
This article introduces a new causal analytic method for survival analysis that retains the framework of Rubin’s causal model as an alternative to the marginal structural model (MSM). The major limitation of the MSM is a systematic bias in the effects of past treatments when the method is applied to the hazard rate analysis of nonrepeatable events in the presence of unobserved heterogeneity. This systematic bias is demonstrated in the article. The method introduced here assumes a semiparametric conditional-incidence-rate model and provides consistent estimates of the effects of present and past treatments on the conditional cumulative-incidence rate in the analysis of nonrepeatable events in the presence of unobserved heterogeneity. Unlike the MSM, which requires a sequential and cumulative use of the inverse-probability-of-treatment weighting many times for data with many time points, the new method uses the inverse-probability-of-treatment weighing only twice sequentially for estimation of the present and past treatment effects at each time of entry into treatment, and not cumulatively across different treatment entry times. Analysis of the conditional-incidence rate can also provide a more efficient parameter estimate for the treatment effect than the hazard rate model in cases where a majority of sample persons experience the event and thereby cease to be members of the risk set of the hazard rate during the period of observation. An application to an analysis of sexual initiation demonstrates that leaving home promotes sexual initiation, especially premarital sexual initiation, because it greatly increases the rate of premarital sexual initiation during the year after leaving home.
本文介绍了一种新的生存分析的因果分析方法,它保留了鲁宾因果模型的框架,作为边际结构模型(MSM)的替代方案。MSM的主要局限性是,当该方法应用于存在未观察到异质性的不可重复事件的危险率分析时,对过去治疗效果的系统性偏倚。这篇文章证明了这种系统性偏见。这里介绍的方法假设了一个半参数条件发病率模型,并在分析存在未观察到异质性的不可重复事件时,对当前和过去治疗对条件累积发病率的影响提供了一致的估计。与MSM不同的是,MSM需要对具有多个时间点的数据进行多次连续累积使用反处理概率加权,而新方法只使用两次连续的反处理概率加权来估计每个进入处理时间的当前和过去的处理效果,而不是在不同的处理进入时间累积。在大多数样本人经历了该事件,因此在观察期间不再是危险率的风险集的成员的情况下,条件发病率的分析也可以提供比危险率模型更有效的治疗效果参数估计。一项对性开始的分析表明,离家促进了性开始,尤其是婚前性开始,因为离家后一年内婚前性开始的比率大大增加。
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引用次数: 0
Survey Methods for Estimating the Size of Weak-Tie Personal Networks 估计弱连接个人网络规模的调查方法
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-07-05 DOI: 10.1177/00811750221109568
D. Feehan, Vo Hai Son, A. Abdul-Quader
Researchers increasingly use aggregate relational data to learn about the size and distribution of survey respondents’ weak-tie personal networks. Aggregate relational data are collected by asking questions about respondents’ connectedness to many different groups (e.g., “How many teachers do you know?”). This approach can be powerful, but to use aggregate relational data, researchers must locate external information about the size of each group from a census or administrative records (e.g., the number of teachers in the population). This need for external information makes aggregate relational data difficult or impossible to collect in many settings. Here, the authors show that relatively simple modifications can overcome this need for external data, significantly increasing the flexibility of the method and weakening key assumptions required by the associated estimators. The key idea is to estimate the size of these groups from the sample of survey respondents, rather than relying on external sources of information. These methods are appropriate for using a sample survey to study the size and distribution of weak-tie network connections. They can also be used as part of the network scale-up method to estimate the size of hidden populations. The authors illustrate this approach with two empirical studies: a large simulation study and original household survey data collected in Hanoi, Vietnam.
研究人员越来越多地使用聚合关系数据来了解调查对象的弱联系个人网络的规模和分布。通过询问受访者与许多不同群体的联系来收集总体关系数据(例如,“你认识多少老师?”)。这种方法可能很强大,但要使用聚合关系数据,研究人员必须从人口普查或行政记录(例如,人口中教师的数量)中找到关于每个群体规模的外部信息。这种对外部信息的需求使得在许多设置中很难或不可能收集聚合关系数据。在这里,作者表明,相对简单的修改可以克服这种对外部数据的需求,显著增加了方法的灵活性,并削弱了相关估计器所需的关键假设。关键的想法是从调查受访者的样本中估计这些群体的规模,而不是依赖外部信息来源。这些方法适用于使用抽样调查来研究弱联系网络连接的大小和分布。它们也可以作为网络放大方法的一部分来估计隐藏种群的大小。作者通过两项实证研究说明了这一方法:一项大型模拟研究和在越南河内收集的原始家庭调查数据。
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引用次数: 5
An Implausible Virtual Interview: Conversations with a Professional Research Subject 一个不真实的虚拟访谈:与一个专业研究对象的对话
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-06-22 DOI: 10.1177/00811750221106777
L. Owens
The author explores interactions with one research subject who feigns credentials and invents stories in order to participate in social science research interviews online. The possibility of intentional deception among interviewees in virtually mediated fieldwork is a critical consideration in the context of the recent extensive pivot to online-based fieldwork during the need for social distancing associated with the coronavirus disease 2019 pandemic. Following this rapid shift in what is generally accepted as the “gold standard” for social science research interviews, widespread use of online-based interviewing methods will likely endure as equivalent to in-person methods. A methodological case study with implications for virtually mediated fieldwork, this article highlights some of the advantages and disadvantages of virtually mediated interviews and provides practical suggestions.
作者探索了与一位研究对象的互动,这位研究对象为了参加在线社会科学研究采访而伪造证书并编造故事。在与2019冠状病毒病大流行相关的社交距离需求期间,最近广泛转向在线实地调查的背景下,受访者在虚拟中介的实地调查中故意欺骗的可能性是一个关键考虑因素。随着人们普遍认为的社会科学研究面试“金标准”的迅速转变,在线面试方法的广泛使用可能会像面对面面试方法一样持续下去。本文是一个方法论案例研究,对虚拟中介实地调查具有启示意义,强调了虚拟中介访谈的一些优点和缺点,并提供了实用的建议。
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引用次数: 3
Decomposing Ethnic Achievement Gaps across Multiple Levels of Analysis and for Multiple Ethnic Groups 跨多个层次分析和多民族的民族成就差距分解
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-06-08 DOI: 10.1177/00811750221099503
Beatriz Gallo Cordoba, G. Leckie, W. Browne
Ethnic achievement gaps are often explained in terms of student and school factors. The decomposition of these gaps into their within- and between-school components has therefore been applied as a strategy to quantify the overall influence of each set of factors. Three competing approaches have previously been proposed, but each is limited to the study of student-school decompositions of the gap between two ethnic groups (e.g., White and Black). The authors show that these approaches can be reformulated as mediation models facilitating new extensions to allow additional levels in the school system (e.g., classrooms, school districts, geographic areas) and multiple ethnic groups (e.g., White, Black, Hispanic, Asian). The authors illustrate these extensions using administrative data for high school students in Colombia and highlight the increased substantive insights and nuanced policy implications they afford.
种族成就差距通常是从学生和学校因素的角度来解释的。因此,将这些差距分解为学校内部和学校之间的组成部分,作为量化每组因素的总体影响的策略。之前已经提出了三种相互竞争的方法,但每种方法都仅限于研究两个种族群体(如白人和黑人)之间差距的学生-学校分解。作者表明,这些方法可以重新制定为调解模式,促进新的扩展,以允许学校系统(如教室、学区、地理区域)和多个种族群体(如白人、黑人、西班牙裔、亚裔)的额外级别。作者使用哥伦比亚高中生的行政数据说明了这些扩展,并强调了它们提供的更多实质性见解和微妙的政策影响。
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引用次数: 0
Lorenz Interpolation: A Method for Estimating Income Inequality from Grouped Income Data 洛伦兹插值:一种从分组收入数据中估计收入不平等的方法
IF 3 2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-04-07 DOI: 10.1177/00811750221085586
Andrew Carr
To understand how income inequality affects individuals and communities, researchers must have accurate measures of income inequality at lower geographic levels, such as counties, school districts, and census tracts. Studies of income inequality, however, are constrained by the tabular format in which censuses publish income data. In this article, the author proposes a new method, Lorenz interpolation, for estimating income inequality from binned income data. Using public microsample data from the American Community Survey (ACS), the author shows that Lorenz interpolation produces more accurate and reliable income inequality estimates than do alternative estimation methods. Then, using restricted ACS income data obtained through a Federal Statistical Research Data Center, the author evaluates the accuracy of Lorenz interpolation at the census tract and school district levels. Lorenz interpolation produces reliable school district–level estimates, but the method produces less reliable estimates for some income inequality measures at the tract level. These findings indicate that researchers should refrain from estimating tract-level income inequality measures from tabular data. They also show that aggregating tract income distributions to higher geographic levels can produce valid estimates of income inequality.
为了了解收入不平等如何影响个人和社区,研究人员必须准确衡量较低地理水平的收入不平等,如县、学区和人口普查区。然而,对收入不平等的研究受到人口普查公布收入数据的表格格式的限制。在这篇文章中,作者提出了一种新的方法,洛伦兹插值,以估计收入不平等的合并收入数据。利用美国社区调查(ACS)的公共微观样本数据,作者表明洛伦茨插值比其他估计方法产生了更准确、更可靠的收入不平等估计。然后,使用通过联邦统计研究数据中心获得的限制性ACS收入数据,作者评估了Lorenz插值在人口普查区和学区层面的准确性。洛伦兹插值产生了可靠的学区水平估计,但该方法对地区水平的一些收入不平等指标产生了不太可靠的估计。这些发现表明,研究人员应该避免从表格数据中估计地区层面的收入不平等指标。他们还表明,将地区收入分配汇总到更高的地理水平可以产生对收入不平等的有效估计。
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引用次数: 0
Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study. 美国 SARS-CoV-2(Omicron、delta 和 alpha)变种 covid-19 的临床严重性和 mRNA 疫苗的有效性:前瞻性观察研究。
2区 社会学 Q1 SOCIOLOGY Pub Date : 2022-03-09 DOI: 10.1136/bmj-2021-069761
Adam S Lauring, Mark W Tenforde, James D Chappell, Manjusha Gaglani, Adit A Ginde, Tresa McNeal, Shekhar Ghamande, David J Douin, H Keipp Talbot, Jonathan D Casey, Nicholas M Mohr, Anne Zepeski, Nathan I Shapiro, Kevin W Gibbs, D Clark Files, David N Hager, Arber Shehu, Matthew E Prekker, Heidi L Erickson, Matthew C Exline, Michelle N Gong, Amira Mohamed, Nicholas J Johnson, Vasisht Srinivasan, Jay S Steingrub, Ithan D Peltan, Samuel M Brown, Emily T Martin, Arnold S Monto, Akram Khan, Catherine L Hough, Laurence W Busse, Caitlin C Ten Lohuis, Abhijit Duggal, Jennifer G Wilson, Alexandra June Gordon, Nida Qadir, Steven Y Chang, Christopher Mallow, Carolina Rivas, Hilary M Babcock, Jennie H Kwon, Natasha Halasa, Carlos G Grijalva, Todd W Rice, William B Stubblefield, Adrienne Baughman, Kelsey N Womack, Jillian P Rhoads, Christopher J Lindsell, Kimberly W Hart, Yuwei Zhu, Katherine Adams, Stephanie J Schrag, Samantha M Olson, Miwako Kobayashi, Jennifer R Verani, Manish M Patel, Wesley H Self
<p><strong>Objectives: </strong>To characterize the clinical severity of covid-19 associated with the alpha, delta, and omicron SARS-CoV-2 variants among adults admitted to hospital and to compare the effectiveness of mRNA vaccines to prevent hospital admissions related to each variant.</p><p><strong>Design: </strong>Case-control study.</p><p><strong>Setting: </strong>21 hospitals across the United States.</p><p><strong>Participants: </strong>11 690 adults (≥18 years) admitted to hospital: 5728 with covid-19 (cases) and 5962 without covid-19 (controls). Patients were classified into SARS-CoV-2 variant groups based on viral whole genome sequencing, and, if sequencing did not reveal a lineage, by the predominant circulating variant at the time of hospital admission: alpha (11 March to 3 July 2021), delta (4 July to 25 December 2021), and omicron (26 December 2021 to 14 January 2022).</p><p><strong>Main outcome measures: </strong>Vaccine effectiveness calculated using a test negative design for mRNA vaccines to prevent covid-19 related hospital admissions by each variant (alpha, delta, omicron). Among patients admitted to hospital with covid-19, disease severity on the World Health Organization's clinical progression scale was compared among variants using proportional odds regression.</p><p><strong>Results: </strong>Effectiveness of the mRNA vaccines to prevent covid-19 associated hospital admissions was 85% (95% confidence interval 82% to 88%) for two vaccine doses against the alpha variant, 85% (83% to 87%) for two doses against the delta variant, 94% (92% to 95%) for three doses against the delta variant, 65% (51% to 75%) for two doses against the omicron variant; and 86% (77% to 91%) for three doses against the omicron variant. In-hospital mortality was 7.6% (81/1060) for alpha, 12.2% (461/3788) for delta, and 7.1% (40/565) for omicron. Among unvaccinated patients with covid-19 admitted to hospital, severity on the WHO clinical progression scale was higher for the delta versus alpha variant (adjusted proportional odds ratio 1.28, 95% confidence interval 1.11 to 1.46), and lower for the omicron versus delta variant (0.61, 0.49 to 0.77). Compared with unvaccinated patients, severity was lower for vaccinated patients for each variant, including alpha (adjusted proportional odds ratio 0.33, 0.23 to 0.49), delta (0.44, 0.37 to 0.51), and omicron (0.61, 0.44 to 0.85).</p><p><strong>Conclusions: </strong>mRNA vaccines were found to be highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants, but three vaccine doses were required to achieve protection against omicron similar to the protection that two doses provided against the delta and alpha variants. Among adults admitted to hospital with covid-19, the omicron variant was associated with less severe disease than the delta variant but still resulted in substantial morbidity and mortality. Vaccinated patients admitted to hospital with cov
目的描述入院成人中与α、δ和ΩSARS-CoV-2变异体相关的covid-19的临床严重程度,并比较mRNA疫苗在预防与每种变异体相关的入院治疗方面的效果:病例对照研究。研究地点:全美 21 家医院:入院的 11 690 名成人(≥18 岁):5728 人接种了 covid-19(病例),5962 人未接种 covid-19(对照)。根据病毒全基因组测序结果将患者分为SARS-CoV-2变异体组,如果测序结果未显示血统,则根据入院时的主要循环变异体将患者分为阿尔法组(2021年3月11日至7月3日)、德尔塔组(2021年7月4日至12月25日)和奥米克隆组(2021年12月26日至2022年1月14日):采用 mRNA 疫苗的阴性试验设计计算疫苗有效性,以预防各变体(α、δ、ocmicron)与 covid-19 相关的入院治疗。在因covid-19入院的患者中,采用比例几率回归法比较了不同变异株在世界卫生组织临床进展量表中的疾病严重程度:结果:mRNA疫苗预防covid-19相关住院病例的效果为:接种两剂疫苗预防α变异株的效果为85%(95%置信区间为82%至88%);接种两剂疫苗预防δ变异株的效果为85%(83%至87%);接种三剂疫苗预防δ变异株的效果为94%(92%至95%);接种两剂疫苗预防Ω变异株的效果为65%(51%至75%);接种三剂疫苗预防Ω变异株的效果为86%(77%至91%)。阿尔法型的院内死亡率为 7.6%(81/1060),德尔塔型为 12.2%(461/3788),奥米克龙型为 7.1%(40/565)。在入院的未接种疫苗的covid-19患者中,δ变异型与α变异型相比,在世界卫生组织临床进展量表中的严重程度更高(调整后比例几率比1.28,95%置信区间为1.11至1.46),而ocmicron变异型与δ变异型相比,严重程度更低(0.61,0.49至0.77)。与未接种疫苗的患者相比,接种疫苗的患者每个变体的严重程度都较低,包括α变体(调整后比例几率比0.33,0.23至0.49)、δ变体(0.44,0.37至0.51)和奥米克隆变体(0.61,0.44至0.85)。结论:研究发现,mRNA疫苗对预防与covid-19相关的α、δ和ogicron变异型入院治疗非常有效,但需要接种三剂疫苗才能达到预防ogicron的效果,这与接种两剂疫苗预防δ和α变异型的效果相似。在因感染 covid-19 而入院的成年人中,与 delta 变体相比,ocmicron 变体的病情较轻,但仍会导致大量的发病率和死亡率。就所有变异株而言,接种了covid-19疫苗的住院病人的疾病严重程度明显低于未接种疫苗的病人。
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Patients were classified into SARS-CoV-2 variant groups based on viral whole genome sequencing, and, if sequencing did not reveal a lineage, by the predominant circulating variant at the time of hospital admission: alpha (11 March to 3 July 2021), delta (4 July to 25 December 2021), and omicron (26 December 2021 to 14 January 2022).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;Vaccine effectiveness calculated using a test negative design for mRNA vaccines to prevent covid-19 related hospital admissions by each variant (alpha, delta, omicron). Among patients admitted to hospital with covid-19, disease severity on the World Health Organization's clinical progression scale was compared among variants using proportional odds regression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Effectiveness of the mRNA vaccines to prevent covid-19 associated hospital admissions was 85% (95% confidence interval 82% to 88%) for two vaccine doses against the alpha variant, 85% (83% to 87%) for two doses against the delta variant, 94% (92% to 95%) for three doses against the delta variant, 65% (51% to 75%) for two doses against the omicron variant; and 86% (77% to 91%) for three doses against the omicron variant. In-hospital mortality was 7.6% (81/1060) for alpha, 12.2% (461/3788) for delta, and 7.1% (40/565) for omicron. Among unvaccinated patients with covid-19 admitted to hospital, severity on the WHO clinical progression scale was higher for the delta versus alpha variant (adjusted proportional odds ratio 1.28, 95% confidence interval 1.11 to 1.46), and lower for the omicron versus delta variant (0.61, 0.49 to 0.77). Compared with unvaccinated patients, severity was lower for vaccinated patients for each variant, including alpha (adjusted proportional odds ratio 0.33, 0.23 to 0.49), delta (0.44, 0.37 to 0.51), and omicron (0.61, 0.44 to 0.85).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;mRNA vaccines were found to be highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants, but three vaccine doses were required to achieve protection against omicron similar to the protection that two doses provided against the delta and alpha variants. Among adults admitted to hospital with covid-19, the omicron variant was associated with less severe disease than the delta variant but still resulted in substantial morbidity and mortality. Vaccinated patients admitted to hospital with cov","PeriodicalId":48140,"journal":{"name":"Sociological Methodology","volume":"43 1","pages":"e069761"},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86913270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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