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Key factors in complex public health interventions to address vaccine hesitancy using a multidisciplinary approach: the VAX-TRUST project. 采用多学科方法解决疫苗接种犹豫问题的复杂公共卫生干预措施的关键因素:VAX-TRUST 项目。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-17 DOI: 10.1093/her/cyae027
Maria Ferrara, Elisa Langiano, Maurizio Esposito, Giuseppina Lo Moro, Rosalia Lombardi, Pia Vuolanto, Elisabetta De Vito

The VAX-TRUST project addresses vaccine hesitancy in seven European countries with a systematic and evidence-based approach. Interventions, targeting healthcare professionals, draw from behavioural and social theories. A checklist, inspired by the TIDieR (Template for Intervention Description and Replication), ensures a detailed description of actions, transparency and replicability. The intervention development process begins with collaborative meetings and systematic revisions, concluding with external evaluations for replicability in diverse public health contexts. This study aims to provide valuable insights for future complex interventions in public health, based on lessons learnt to reduce the risk of vaccine-preventable diseases. The analysis of educational interventions within the VAX-TRUST project has led to the definition of precise guidelines to ensure their replicability and adaptation to various contexts, attempting to establish a universally applicable approach. Active participant engagement and consideration of local social dynamics, beyond information transmission, have emerged as key factors to improve intervention effectiveness. Various educational tools and collaboration with academic institutions have contributed to strengthening credibility.

VAX-TRUST 项目采用系统的循证方法来解决七个欧洲国家的疫苗接种犹豫问题。针对医疗保健专业人员的干预措施借鉴了行为和社会理论。受 TIDieR(干预措施描述和复制模板)启发而制定的清单确保了行动的详细描述、透明度和可复制性。干预措施的开发过程始于合作会议和系统性修订,最后是在不同的公共卫生背景下进行可复制性的外部评估。本研究的目的是在吸取经验教训的基础上,为公共卫生领域未来的复杂干预措施提供有价值的见解,以降低疫苗可预防疾病的风险。通过对 VAX-TRUST 项目中的教育干预措施进行分析,确定了精确的指导方针,以确保其可复制性和适应各种环境,并试图建立一种普遍适用的方法。除信息传播外,参与者的积极参与和对当地社会动态的考虑已成为提高干预效果的关键因素。各种教育工具以及与学术机构的合作有助于提高可信度。
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引用次数: 0
Characteristics of people with type 1 diabetes influence the educational process for starting insulin pump therapy: an observational study. 1 型糖尿病患者的特征对开始胰岛素泵治疗的教育过程的影响:一项观察性研究。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-17 DOI: 10.1093/her/cyae030
Verónica Izquierdo, Marcos Pazos-Couselo, María González-Rodríguez, Alba-Elena Martínez-Santos, Paula Andujar-Plata, Olaia Díaz-Trastoy, Antía Fernández-Pombo, Sara Sigüeiro-Paulos, Raquel Rodríguez-González

Limited data exist on educational programs for people using insulin pump (IP) therapy or those considering its initiation, and the influence of individual characteristics on their educational pathway remains unclear. Our aim was to analyze the characteristics of people with type 1 diabetes (T1D) referred for IP therapy and how these characteristics may influence their educational process. A retrospective descriptive observational study was carried out on people with T1D referred for participation in a structured pre-IP educational program in a hospital setting. Educational, sociodemographic and clinical variables were collected and analyzed. Participants were followed up 5 years after IP placement. Seventy-one people finalized the educational program, of whom 10 experienced major barriers to completing it. People with lower educational level required more sessions and weeks to complete it compared to those with higher educational levels. People referred due to suboptimal metabolic control and hypoglycemia also required more time to complete the process. It is essential for diabetes educators to recognize the diversity of characteristics, needs and challenges among the participants in an educational program. Based on this, they must adapt strategies to provide more effective, person-centered diabetes education and support, fostering positive and sustained outcomes and engagement for participants.

针对正在使用胰岛素泵(IP)治疗或考虑开始胰岛素泵治疗的患者的教育计划数据有限,而且个人特征对其教育途径的影响仍不明确。我们的目的是分析转诊接受胰岛素泵治疗的 1 型糖尿病(T1D)患者的特征,以及这些特征会如何影响他们的教育过程。我们对转诊到医院参加结构化 IP 前教育项目的 1 型糖尿病患者进行了一项回顾性描述观察研究。研究收集并分析了教育、社会人口学和临床变量。在植入 IP 5 年后,对参与者进行了随访。71人完成了教育计划,其中10人在完成计划时遇到了重大障碍。与教育水平较高的人相比,教育水平较低的人需要更多的课程和更长的周数才能完成。因代谢控制不佳和低血糖而转诊的患者也需要更多时间来完成这一过程。糖尿病教育工作者必须认识到教育计划参与者的特点、需求和挑战的多样性。在此基础上,他们必须调整策略,提供更有效的、以人为本的糖尿病教育和支持,为参与者带来积极、持久的成果和参与感。
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引用次数: 0
A Neighbourhood-oriented approach to foster healthy ageing in low socioeconomic older adults: development and protocol for evaluation through intervention mapping. 促进社会经济地位较低的老年人健康老龄化的面向社区的办法:通过干预绘图进行评估的发展和规程。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-14 DOI: 10.1093/her/cyae041
Lieke J E Duijsens, Lilian Lechner, Denise A Peels, Catherine A W Bolman

The rapid ageing of our society poses significant challenges, including an increase in chronic diseases and loneliness among older adults, leading to higher demands for care and support. Addressing these needs requires an integral approach, especially among older adults with low socioeconomic status (SES). This article details the development of the Neighbourhood Active & Connected (NAC) intervention, using the Intervention Mapping framework to expand an evidence-based physical activity intervention into a neighbourhood-oriented, holistic and systemic strategy for healthy ageing. NAC focuses on enhancing physical activity, social connectedness, and digital literacy. It was developed through co-creation with local stakeholders and low-SES older adults, ensuring optimal alignment with their needs and capabilities. Performance and change objectives were established based on literature consultation and an extensive need assessment, with intervention materials refined through engagement with the target group. The results of a large-scale cluster randomised controlled trial will be utilised to evaluate NAC's impact on physical activity, loneliness, social cohesion, health-related quality of life, and digital literacy among low-SES community-dwelling older adults. This paper aims to provide a detailed roadmap for researchers and practitioners to adapt, implement and evaluate similar interventions, promoting healthy ageing in low socio-economic contexts.

我们社会的迅速老龄化带来了重大挑战,包括老年人中慢性病和孤独感的增加,导致对护理和支持的更高需求。解决这些需求需要采取综合方法,特别是在社会经济地位较低的老年人中。本文详细介绍了社区积极与连接(NAC)干预的发展,使用干预绘图框架将基于证据的身体活动干预扩展为面向社区的健康老龄化整体和系统战略。NAC的重点是加强身体活动、社会联系和数字素养。它是通过与当地利益相关者和低经济地位老年人共同创造而开发的,确保与他们的需求和能力保持最佳一致。绩效和变革目标是在文献咨询和广泛需求评估的基础上建立的,干预材料通过与目标群体的接触而得到完善。一项大规模集群随机对照试验的结果将用于评估NAC对低社会经济地位社区居住老年人的身体活动、孤独感、社会凝聚力、健康相关生活质量和数字素养的影响。本文旨在为研究人员和从业人员提供详细的路线图,以适应,实施和评估类似的干预措施,促进低社会经济背景下的健康老龄化。
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引用次数: 0
A qualitative analysis of factors influencing physical activity behaviour in women with PCOS: key learning for physical activity interventions and beyond. 多囊卵巢综合征女性身体活动行为影响因素的定性分析:身体活动干预及其他方面的关键学习。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-10 DOI: 10.1093/her/cyae040
Amie Woodward, Markos Klonizakis, David Broom, Rachel Cholerton, Hilary Piercy

Physical activity (PA) is recommended in clinical practice guidelines as effective for the management of polycystic ovary syndrome (PCOS). However, adherence to PA interventions is low in this population, and long-term uptake of PA is a challenge. We conducted a feasibility trial of two PA interventions for women with PCOS. This paper reports a qualitative evaluation of the trial in tandem with an evaluation of barriers and facilitators to PA in a sub-group of participants. Eleven participants with PCOS were purposively sampled from the main sample (n = 36) and participated in semi-structured interviews. Interviews were audio-recorded and transcribed verbatim. Data were analysed using reflexive thematic analysis. Five themes were developed relating to experiences of the intervention and factors influencing PA behaviour: (1) The Changing Nature of Priorities, (2) The Push and Pull of PCOS Symptoms, (3) Focusing Beyond the Scale, (4) Knowledge as a Foundation for Change and (5) The Balance of Stigma and Social Support. These findings can be used to design PA interventions that consider the interplay between PCOS and PA behaviour to achieve health benefits beyond short-term interventions.

在临床实践指南中,体力活动(PA)被推荐为治疗多囊卵巢综合征(PCOS)的有效方法。然而,在这一人群中,对PA干预措施的依从性很低,长期服用PA是一个挑战。我们对PCOS女性进行了两种PA干预的可行性试验。本文报告了对试验的定性评估,以及对参与者亚组中PA障碍和促进因素的评估。从主样本(n = 36)中有意抽取11名多囊卵巢综合征患者参加半结构化访谈。采访录音并逐字抄写。数据分析采用反身性主题分析。五个主题与干预经验和影响PA行为的因素有关:(1)优先事项的变化性质,(2)多囊卵巢综合征症状的推拉,(3)超越尺度的关注,(4)知识作为改变的基础,(5)污名和社会支持的平衡。这些发现可用于设计考虑多囊卵巢综合征和PA行为之间相互作用的PA干预措施,以实现超越短期干预的健康益处。
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引用次数: 0
How are pro- and anti-cannabis messaging exposures related to US young adult cannabis use-related factors? 支持和反对大麻的信息暴露与美国年轻人大麻使用相关因素有何关系?
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-09 DOI: 10.1093/her/cyae038
Yuxian Cui, Cassidy R LoParco, Katelyn F Romm, Patricia A Cavazos-Rehg, Y Tony Yang, Darcey M McCready, Erin Kasson, Yan Wang, Carla J Berg

Given the diverse sources of cannabis messaging and potential differential effects, this study examined pro- and anti-cannabis messaging exposure overall and via specific channels in relation to cannabis-related perceptions (social acceptability and harm) and behaviors (use status, intentions and frequency; past-year quit attempts). Multivariable regression analyses of 2023 survey data from 4031 US young adults (Mage = 26.29, 59.4% female, 19.0% Hispanic, 13.5% Black and 13.6% Asian) used independent variables representing overall exposure and via specific sources (stores, online, billboards/posters/flyers, TV/movies/radio, print and direct communication), respectively. Greater pro-cannabis messaging exposure correlated with greater perceived social acceptability, lower perceived harm, past-month use, greater use intentions among those reporting past-month nonuse and more days used and fewer quit attempts among those reporting use. Less anti-cannabis messaging exposure correlated with these outcomes, except intentions. Particularly, influential sources of pro-cannabis messaging were online (associated with perceptions, use status, intentions and frequency) and direct communication (perceptions, use, use frequency and quit attempts), and those of anti-cannabis messaging were online (harm and use intentions), direct communication (acceptability, quit attempts) and stores (perceptions, use and quit attempts). Exposure differed by sociodemographics (e.g. sex, race/ethnicity and education). The impact of digital media and targeted communications overall and stores in communicating cannabis-related risks suggest the need for regulation and monitoring.

考虑到大麻信息的不同来源和潜在的不同影响,本研究通过与大麻相关的认知(社会可接受性和危害)和行为(使用状况、意图和频率;过去一年的戒烟尝试)。对来自4031名美国年轻人(男性= 26.29,女性59.4%,西班牙裔19.0%,黑人13.5%,亚洲13.6%)的2023项调查数据进行多变量回归分析,分别使用代表总体曝光率和特定来源(商店、在线、广告牌/海报/传单、电视/电影/广播、印刷和直接传播)的自变量。更多的支持大麻的信息暴露与更高的感知社会可接受性、更低的感知危害、过去一个月的使用、报告过去一个月未使用的更大的使用意图、报告使用的更长的使用天数和更少的戒烟尝试相关。除意图外,较少的反大麻信息暴露与这些结果相关。特别是,支持大麻的有影响力的信息来源是在线(与看法、使用状况、意图和频率有关)和直接沟通(与看法、使用、使用频率和戒烟企图有关),而反对大麻的信息来源是在线(伤害和使用意图)、直接沟通(可接受性、戒烟企图)和商店(看法、使用和戒烟企图)。暴露程度因社会人口统计学(如性别、种族/民族和教育程度)而异。数字媒体和有针对性的通信的整体影响以及传播大麻相关风险的商店表明需要进行监管和监测。
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引用次数: 0
A novel prenatal alcohol use risk perception model: feedback from a Delphi process. 新型产前酒精使用风险认知模型:德尔菲进程的反馈。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-12-05 DOI: 10.1093/her/cyae037
May Na Erng, Natasha Reid, Karen M Moritz, Mieke van Driel

Understanding prenatal alcohol exposure (PAE) risk perception is important for the communication and prevention of alcohol use during pregnancy. A previous systematic review has explored the dimensions and influencing factors of women's PAE risk perceptions, leading to the construction of Pregnancy Alcohol Use Risk Perception (PARP) conceptual model. This study aims to refine the PARP model using a Delphi process. A total of 37 international experts participated, 17 completed all three online surveys between May 2022 and December 2022. The online survey consisted of Likert-scale and free-text responses on the usefulness and clarity of the components and the design of the PARP model. Likert-scale responses were analysed using descriptive statistics. Free-text responses were analysed using a reflexive thematic analysis approach. The model was amended following participants' responses. Four characteristics underpinned the revised model-relevance-to-self and the negotiations of risks, inter-relatedness of affect with the cognitive processing of risk, contextual influences of individual, sociocultural and institutional/political/organizational rendering a socioecological perspective to PAE risks perception and the dynamic characteristics of PAE risk perception. The acknowledgement of PAE risk perceptions and the contextual influences can support development of targeted and tailored messages and health education materials.

了解产前酒精暴露(PAE)风险认知对于孕期酒精使用的交流和预防非常重要。之前的一项系统性综述探讨了妇女对 PAE 风险认知的维度和影响因素,并由此构建了妊娠期酒精使用风险认知(PARP)概念模型。本研究旨在采用德尔菲法完善 PARP 模型。共有 37 名国际专家参与,其中 17 人在 2022 年 5 月至 2022 年 12 月期间完成了全部三项在线调查。在线调查包括李克特量表和自由文本回答,内容涉及 PARP 模型各组成部分和设计的实用性和清晰度。李克特量表答卷采用描述性统计进行分析。自由文本回复则采用反思性专题分析方法进行分析。根据参与者的答复,对模型进行了修订。修订后的模型具有四个基本特征--与自我的相关性和风险协商;情感与风险认知处理的相互关联性;个人、社会文化和机构/政治/组织的背景影响,从社会生态学角度呈现 PAE 风险感知;以及 PAE 风险感知的动态特征。对 PAE 风险认知和背景影响的认识有助于开发有针对性的定制信息和健康教育材料。
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引用次数: 0
Challenges in implementing school-based drug prevention programs led by law enforcement officers. 在执行由执法人员领导的以学校为基础的毒品预防方案方面面临的挑战。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-11-29 DOI: 10.1093/her/cyae039
Juliana Y Valente, Julia D Gusmões, Rodrigo Garcia-Cerde, Tania Pietrobon, Zila M Sanchez

School-based prevention drug programs in the United States and Brazil are most commonly delivered by law enforcement officers (LEOs). However, limited research has explored challenges involved in the delivery of these interventions specifically related to their implementation by LEOs. We aim to describe the challenges affecting the implementation of school-based drug prevention programs delivered by LEOs. We conducted a qualitative study using 31 semi-structured interviews with LEOs who delivered the Brazilian version of the DARE-Keepin' it REAL program (fifth- and seventh-grade curriculum) and 8 focus groups with 80 students who participated in the program. All data were thematically analyzed. LEOs perceived devaluation from the police corporation, resulting in resource limitations and commanders' resistance to adapting schedules. Relationships with the school community posed additional challenges. Fifth graders seemed generally positive about LEOs' presence while seventh graders showed more negative responses. LEOs' street-level policing experiences influenced their approach to clarifying the consequences of drug use and willingness to share related experiences, even though this content is not part of the program. Therefore, it is crucial to consider alternative approaches to delivering preventive programs in schools, while simultaneously improving the training of LEOs already involved in program implementation to ensure alignment with evidence-based practices.

在美国和巴西,以学校为基础的预防毒品项目通常由执法人员实施。然而,有限的研究探索了在提供这些干预措施方面所涉及的挑战,特别是与leo实施这些干预措施有关的挑战。我们的目的是描述影响执行由LEOs提供的以学校为基础的毒品预防方案的挑战。我们进行了一项定性研究,使用了31个半结构化访谈,访谈对象是负责巴西版DARE-Keepin' it REAL项目(五年级和七年级课程)的学习主管,以及8个焦点小组,包括80名参与该项目的学生。对所有数据进行主题分析。低领导者认为警察公司的贬值,导致资源限制和指挥官抵制调整时间表。与学校社区的关系带来了额外的挑战。五年级学生似乎普遍对狮子座的存在持积极态度,而七年级学生则表现出更多的消极反应。LEOs的街头警务经验影响了他们澄清吸毒后果的方法,并愿意分享相关经验,尽管这些内容不是项目的一部分。因此,至关重要的是要考虑在学校提供预防项目的替代方法,同时加强对已经参与项目实施的基层领导的培训,以确保与循证实践保持一致。
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引用次数: 0
The effect of health education on symptom severity in patients with fibromyalgia: a systematic review and meta-analysis. 健康教育对纤维肌痛患者症状严重程度的影响:系统回顾与荟萃分析。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-11-01 DOI: 10.1093/her/cyae035
Huan-Xi Huang, Renny Wulan Apriliyasari, Pei-Shan Tsai

Fibromyalgia (FM) is a complex chronic disorder characterized by widespread pain as the primary symptom. To evaluate the effect of health education on the severity of various symptoms in patients with FM, seven databases were searched from inception to August 2024 to identify randomized controlled trials evaluating the effects of health education for FM. The primary outcome was overall symptom severity, and the secondary outcomes were pain, depression, anxiety, sleep quality, fatigue, physical function and self-efficacy. The Cochrane Risk-of-Bias tool for randomized trials and the Grading of Recommendations, Assessment, Development, and Evaluations were used to assess the quality of the included studies and the certainty of evidence, respectively. Treatment effects were estimated by calculating Hedges' g and the corresponding 95% confidence intervals. Meta-analysis included a total of 13 trials. The results revealed that health education significantly reduced overall symptom severity, depression and anxiety and increased sleep quality and physical function among patients with FM (all P values < 0.05). However, no significant effects were observed on pain, fatigue and self-efficacy. Health education may be a beneficial intervention for FM patients, particularly for mitigating symptom severity. Health-care providers should implement health education interventions to empower patients to effectively manage their symptoms.

纤维肌痛(FM)是一种以广泛性疼痛为主要症状的复杂慢性疾病。为了评估健康教育对 FM 患者各种症状严重程度的影响,我们检索了从开始到 2024 年 8 月的七个数据库,以确定评估健康教育对 FM 影响的随机对照试验。主要结果为总体症状严重程度,次要结果为疼痛、抑郁、焦虑、睡眠质量、疲劳、身体功能和自我效能。科克伦随机试验偏倚风险工具和推荐、评估、发展和评价分级法分别用于评估纳入研究的质量和证据的确定性。通过计算赫奇斯 g 和相应的 95% 置信区间来估计治疗效果。元分析共纳入了 13 项试验。结果显示,健康教育能明显减轻 FM 患者的整体症状严重程度、抑郁和焦虑,提高睡眠质量和身体功能(所有 P 值均为 0.05)。
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引用次数: 0
The effect of structured psychoeducation for caregivers of ALS patients on perceived stress, psychological resilience and self-compassion. 对 ALS 患者的照顾者进行结构化心理教育对感知压力、心理复原力和自我同情的影响。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-10-04 DOI: 10.1093/her/cyae031
Songül Duran, Arzu Aydogdu

Patients diagnosed with amyotrophic lateral sclerosis (ALS) become dependent on caregivers to meet their daily needs and perform personal care activities. For this reason, ALS is a disease that can challenge both the patient and the caregiver physically, mentally and socially. Supporting the caregiver indirectly affects the patient's quality of care and mental well-being. Therefore, this study aimed to determine the effect of a structured psychoeducation program on coping with stress, psychological resilience and self-compassion in caregivers of ALS patients. This quasi-experimental study with a pre-test-post-test control group was conducted with caregivers of 62 ALS patients in Türkiye. The study was conducted between July 2023 and February 2024. A psychoeducation program was applied to five different groups via zoom application for 6 weeks each. The survey form, Perceived Stress Scale, Brief Resilience Scale and Short Form of Self-Compassion Questionnaire were used as measurement tools. The chi-squared test and paired samples t-test were used to analyze the data. While there was no significant difference between the intervention group and the control group in the pre-test in terms of their mean scores on the coping with stress inventory, short psychological resilience scale and self-compassion scale, at the post-test, psychological resilience and self-compassion scores were significantly higher in the intervention group. This study revealed that psychoeducational programs that support caregivers are effective in increasing psychological resilience and self-compassion.

被诊断出患有肌萎缩侧索硬化症(ALS)的患者需要依赖护理人员来满足其日常需求和进行个人护理活动。因此,肌萎缩侧索硬化症对患者和护理者的身体、精神和社交都是一种挑战。对护理者的支持会间接影响患者的护理质量和心理健康。因此,本研究旨在确定结构化心理教育计划对 ALS 患者护理者应对压力、心理复原力和自我同情的影响。这项准实验研究以土耳其 62 名 ALS 患者的护理人员为对象,采用前测-后测对照组的方法。研究时间为 2023 年 7 月至 2024 年 2 月。心理教育计划通过变焦应用程序应用于五个不同的小组,每个小组为期 6 周。调查表、感知压力量表、简明复原力量表和自我同情问卷简表被用作测量工具。数据分析采用了卡方检验和配对样本 t 检验。虽然干预组与对照组在前测中的压力应对量表、简易心理复原量表和自我同情量表的平均得分没有明显差异,但在后测中,干预组的心理复原力和自我同情得分明显高于对照组。这项研究表明,支持照顾者的心理教育计划能有效提高心理复原力和自我同情能力。
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引用次数: 0
Effectiveness of e-learning material on essential components of evidence-based medicine among laypersons: a randomized controlled trial. 关于循证医学重要组成部分的电子学习材料对非专业人士的效果:随机对照试验。
IF 2.1 4区 医学 Q1 EDUCATION & EDUCATIONAL RESEARCH Pub Date : 2024-09-13 DOI: 10.1093/her/cyae024
Satoe Okabayashi, Kyoko Kitazawa, Hisashi Noma, Yoshimitsu Takahashi, Taku Iwami, Takashi Kawamura, Takeo Nakayama

Evidence-based medicine (EBM) is helpful for laypersons' decision-making. This study aimed to evaluate the effectiveness of e-learning materials on the essential components of EBM for laypersons. We conducted a web-based, open-label, randomized controlled trial with laypersons in Japan aged ≥20 years who used the internet. Participants were randomly assigned to the intervention group with the e-learning material and the control group with only the 'Introduction' section of the same material. The primary and secondary outcomes were the self-created acquirement test scores (responding correctly with confidence) immediately after using the material and after 4 weeks. A multiple linear regression analysis was conducted. Of the 122 participants, 62 were randomly assigned to the intervention group and 59 to the control group; finally, 59 and 58, respectively, were included in the full analysis set. The mean (standard deviation) of the acquirement test score immediately after learning was 14.11 and (3.11) and 11.07 (3.88) in the intervention and control groups, respectively, indicating statistical significance (multivariable P < 0.001). The secondary long-term outcome was also statistically significant. The results showed that the e-learning material was effective for laypersons in acquiring the essential components of EBM. The material may increase laypersons' confidence in appraising health information, which can be used in decision-making.

循证医学(EBM)有助于非专业人士做出决策。本研究旨在评估有关 EBM 基本内容的电子学习材料对非专业人士的有效性。我们在日本对年龄≥20 岁、使用互联网的非专业人士进行了一项基于网络、开放标签、随机对照试验。参与者被随机分配到使用电子学习材料的干预组和仅使用相同材料的 "介绍 "部分的对照组。主要和次要结果是使用教材后立即和 4 周后的自编习得测试得分(有信心正确回答问题)。研究人员进行了多元线性回归分析。在 122 名参与者中,62 人被随机分配到干预组,59 人被分配到对照组;最后,分别有 59 人和 58 人被纳入完整的分析集。干预组和对照组在学习后立即进行的习得测试得分的平均值(标准偏差)分别为 14.11 和(3.11)以及 11.07(3.88),这表明统计学意义(多变量 P
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