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Modulation of Subcellular Redox Homeostasis with Trialkylphosphines. 用三烷基膦调节亚细胞氧化还原稳态
IF 1.2 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-04-27 DOI: 10.2533/chimia.2022.308
Jade Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio is different in each cell compartment. There is a lack of chemical probes able to modulate GSH/GSSG in order to study the impact of redox stress in an organelle specific manner. Here, we highlight the importance of trialkylphosphines to induce reductive stress and how it can be targeted to a specific organelle. Our probe is selectively activated by endogenous nitroreductases, and releases tributylphosphine to trigger redox stress in mitochondria. Mechanistic studies revealed that the induced stress activates a cellular response orchestrated by transcription factor ATF4, which upregulates genes involved in glutathione catabolism.

氧化还原稳态对细胞功能至关重要，其破坏与多种病理有关。氧化还原平衡主要受还原性谷胱甘肽(GSH)和氧化性谷胱甘肽(GSSG)的相对浓度调节。在真核细胞中，这个比例在每个细胞区室中是不同的。为了研究氧化还原应激对细胞器特异性的影响，缺乏能够调节GSH/GSSG的化学探针。在这里，我们强调了三烷基膦诱导还原性应激的重要性，以及它如何靶向特定的细胞器。我们的探针被内源性硝基还原酶选择性激活，并释放三丁基膦触发线粒体中的氧化还原应激。机制研究表明，诱导应激激活了由转录因子ATF4介导的细胞反应，该转录因子上调谷胱甘肽分解代谢相关基因。
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引用次数: 0
At the Intersection of SLA and Sociolinguistics: The Predictive Power of Social Networks During Study Abroad 二语习得与社会语言学的交汇点：留学期间社会网络的预测力
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-03-29 DOI: 10.1111/modl.12763
Kristen M. KENNEDY TERRY
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引用次数: 2
Bridging the Gap Between Willingness to Communicate and Learner Talk 弥合沟通意愿和学习者谈话之间的差距
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-03-27 DOI: 10.1111/modl.12764
N. Ducker
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引用次数: 8
Noun‐Phrase Complexity Measures in Chinese and Their Relationship to L2 Chinese Writing Quality: A Comparison with Topic–Comment‐Unit‐Based Measures 汉语名词-短语复杂性测度及其与二语写作质量的关系:与主题-评论-单位测度的比较
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-03-22 DOI: 10.1111/modl.12766
Xiaofei Lu, Jifeng Wu
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引用次数: 4
The Relationship Between Lexical Coverage and Type of Reading Comprehension in Beginning L2 Spanish Learners 初级二语学习者词汇覆盖与阅读理解类型的关系
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-02-24 DOI: 10.1111/modl.12761
Eric Herman, Michael J. Leeser
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引用次数: 2
“I Look Mexican, So They Assume I Speak Spanish”: Latinx Teacher Candidates’ Experiences With Raciolinguistic Policing “我看起来像墨西哥人，所以他们以为我说西班牙语”:拉丁裔教师候选人的种族语言警察经历
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-02-23 DOI: 10.1111/modl.12762
Christian Fallas-Escobar, Kathryn I. Henderson, Kristen M Lindahl
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引用次数: 6
Retention and Attrition in Early‐Career Foreign Language Teachers in Austria and the United Kingdom 奥地利和英国早期职业外语教师的留存和流失
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-02-23 DOI: 10.1111/modl.12765
Giulia Sulis, Sonja Babic, Astrid Mairitsch, Sarah Mercer, Jun-xi Jin, Jim King
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引用次数: 2
Implementation of an Uncontrolled, Real‐World Task: Vocabulary Learning Opportunities and Students’ Perceptions 一项不受控制的真实世界任务的实施：词汇学习机会和学生的感知
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-01-03 DOI: 10.1111/modl.12742
Youjin Kim, Sanghee Kang, Meredith D'Arienzo
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引用次数: 0
Visualizing Emergent Turn Construction: Seeing Writing While Speaking 视觉化突发转折结构：边看边说
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-01-01 DOI: 10.1111/modl.12748
T. Greer, Zachary Nanbu
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引用次数: 5
Functional Diversification and Progressive Routinization of a Multiword Expression in and for Social Interaction: A Longitudinal L2 Study 社会互动中多词表达的功能多样化和渐进式常规化:一项纵向二语研究
IF 4.9 1区 文学 Q1 EDUCATION & EDUCATIONAL RESEARCH
Modern Language Journal
Pub Date : 2022-01-01 DOI: 10.1111/modl.12758
Simona Pekarek Doehler, Klara Skogmyr Marian
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引用次数: 6
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