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NGS analysis of unexplained Community-Acquired Pneumonia (CAP) cases in South Korea 韩国不明原因社区获得性肺炎(CAP)病例NGS分析
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-22 DOI: 10.17352/jbm.000038
Lim Sooyeon, Lee Jae Kyung, Lee Han Sol, Noh Ji Yun, Song Joon Young, Cheong Hee Jin, Kim Woo Joo
In general, pneumonia has known to be closely associated with respiratory infection of viruses, bacteria, fungi, and parasites. In South Korea, pneumonia is a leading cause of death that continues to threaten public health every year. Through the tertiary hospital-based influenza surveillance system in South Korea, nasopharyngeal swab specimens were obtained from patients with unexplained cases of Community-Acquired Pneumonia (CAP) between 2011 and 2017. After real-time PCR screening using respiratory viral panels, the samples were found negative for 16 common respiratory pathogens including adenovirus, influenza viruses, rhinovirus, respiratory syncytial virus, coronavirus, metapneumovirus, and parainfluenza viruses. The aim of this study was to investigate the patient microbiota and examine the etiology of CAP requiring hospitalization. The nasopharyngeal microbiome of adult patients during CAP was analyzed using Next-Generation Sequencing (NGS) on the Illumina MiSeq platform and a subsequent bioinformatics pipeline. Viral nucleic acids were nearly absent in the samples and failed to generate any sequence reads. On the other hand, samples were enriched with a diverse bacterial community, which was mainly comprised of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus, Moraxella, Acinetobacter, and Rhizobium genera. Despite the diversity of bacterial composition, only a few dominant species with > 1% abundance were identified in each patient sample. Population analysis at the genus level showed that microbial diversity varied according to age, sex, and location.
一般来说,肺炎已知与病毒、细菌、真菌和寄生虫的呼吸道感染密切相关。在韩国,肺炎是每年继续威胁公共卫生的主要死亡原因。通过韩国三级医院流感监测系统,对2011年至2017年不明原因社区获得性肺炎(CAP)患者的鼻咽拭子标本进行了采集。呼吸道病毒面板实时荧光定量PCR筛选后,16种常见呼吸道病原体均呈阴性,包括腺病毒、流感病毒、鼻病毒、呼吸道合胞病毒、冠状病毒、偏肺病毒和副流感病毒。本研究的目的是调查患者的微生物群,并检查CAP需要住院治疗的病因。使用Illumina MiSeq平台上的下一代测序(NGS)和随后的生物信息学管道分析CAP期间成年患者的鼻咽微生物组。病毒核酸在样品中几乎不存在,无法产生任何序列读取。另一方面,样品中细菌群落丰富多样,主要由棒状杆菌、葡萄球菌、链球菌、嗜血杆菌、莫拉菌、不动杆菌和根瘤菌属组成。尽管细菌组成多样,但在每个患者样本中仅鉴定出少数丰度> 1%的优势种。在属水平上的种群分析表明,微生物多样性因年龄、性别和地理位置的不同而不同。
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引用次数: 0
The Economics of Scientific Publishing. 科学出版经济学。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/OMSP9618
Azmaeen Zarif

The peculiar nature of scientific publishing has allowed for a high degree of market concentration and a non-collusive oligopoly. The non-substitutable characteristic of scientific journals has facilitated an environment of market concentration. Acquisition of journals on a capabilities-based approach has seen market concentration increase in favor of a small group of dominant publishers. The digital era of scientific publishing has accelerated concentration. Competition laws have failed to prevent anti-competitive practices. The need for government intervention is debated. The definition of scientific publishing as a public good is evaluated to determine the need for intervention. Policy implications are suggested to increase competitiveness in the short-run and present prestige-maintaining alternatives in the long run. A fundamental change in scientific publishing is required to enable socially efficient and equitable access for wider society's benefit.

科学出版的特殊性质允许高度的市场集中度和非合谋的寡头垄断。科技期刊的不可替代性为市场集中化营造了良好的环境。以能力为基础的方式收购期刊,市场集中度上升,有利于少数占主导地位的出版商。科学出版的数字时代加速了集中。竞争法未能阻止反竞争行为。政府干预的必要性存在争议。对科学出版作为一种公共产品的定义进行评估,以确定干预的必要性。建议政策影响在短期内提高竞争力,并在长期内提供维持声望的替代方案。需要对科学出版进行根本性的变革,以实现社会效率和公平获取,造福更广泛的社会。
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引用次数: 0
Climate Change Imperils Pediatric Health: Child Advocacy Through Fossil Fuel Divestment. 气候变化危及儿童健康:通过化石燃料撤资来倡导儿童权益。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/ZODD9375
Sandra H Jee, Elizabeth Friedman, Ruth A Etzel, Vi T Nguyen, Todd L Sack, Kathi J Kemper

Climate change poses an existential threat to children's health. Divestment of ownership stakes in fossil fuel companies is one tool available to pediatricians to address climate change. Pediatricians are trusted messengers regarding children's health and therefore bear a unique responsibility to advocate for climate and health policies that affect children. Among the impacts of climate change on pediatric patients are allergic rhinitis and asthma; heat-related illnesses; premature birth; injuries from severe storms and fires; vector-borne diseases; and mental illnesses. Children are disproportionately affected as well by climate-related displacement of populations, drought, water shortages, and famine. The human-generated burning of fossil fuels emits greenhouse gases (GHG) such as carbon dioxide, which trap heat in the atmosphere and cause global warming. The US healthcare industry is responsible for 8.5% of the nation's entire greenhouse gases and toxic air pollutants. In this perspectives piece we review the principle of divestment as a strategy for improving childhood health. Healthcare professionals can help combat climate change by embracing divestment in their personal investment portfolios and by their universities, healthcare systems, and professional organizations. We encourage this collaborative organizational effort to reduce greenhouse gas emissions.

气候变化对儿童的健康构成生死存亡的威胁。撤资化石燃料公司的股权是儿科医生应对气候变化的一个可用工具。儿科医生是儿童健康方面值得信赖的信使,因此在倡导影响儿童的气候和健康政策方面负有独特的责任。气候变化对儿科患者的影响包括变应性鼻炎和哮喘;热疾病;早产;严重风暴和火灾造成的伤害;病媒传播疾病;还有精神疾病。与气候相关的人口流离失所、干旱、水资源短缺和饥荒也对儿童造成了不成比例的影响。人类燃烧化石燃料会排放二氧化碳等温室气体(GHG),这些气体会将热量困在大气中,导致全球变暖。美国医疗保健行业排放的温室气体和有毒空气污染物占全国总量的8.5%。在这方面的观点片,我们检讨撤资的原则,以改善儿童健康的战略。医疗保健专业人员可以通过在他们的个人投资组合以及他们的大学、医疗保健系统和专业组织中接受撤资来帮助应对气候变化。我们鼓励这种减少温室气体排放的组织合作努力。
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引用次数: 1
Exacerbation of Renal, Cardiovascular, and Respiratory Outcomes Associated with Changes in Climate. 与气候变化相关的肾脏、心血管和呼吸结果恶化
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/KYDF6093
David Baraghoshi, Cameron Niswander, Matthew Strand, Stefan Wheat, Julie Ramstetter, Nicholas Stoll, Jacob Fox, Katherine A James

Exposure to environmental variables including declining air quality and increasing temperatures can exert detrimental effects on human health including acute exacerbations of chronic diseases. We aim to investigate the association between these exposures and acute health outcomes in a rural community in Colorado. Meteorological and adult emergency department visit data were retrospectively collected (2013-2017); for asthma outcomes, additional data were available (2003-2017). Daily environmental exposure data included PM10, maximum daily temperature (MDT), and mean humidity and precipitation. Total daily counts of emergency department (ED) diagnoses for myocardial infarction, congestive heart failure, urolithiasis, and exacerbation of chronic obstructive pulmonary disease (COPD) and asthma, were calculated during the study period. Time series models using generalized estimating equations were fit for each disease and included all four environmental factors. Between 2013 and 2017, asthma and COPD exacerbation accounted for 30.8% and 25.4% of all ED visits (n=5,113), respectively. We found that for every 5˚C increase in MDT, the rate of urolithiasis visits increased by 13% (95% CI: 2%, 26%) and for every 10μg/m3 increase in 3-day moving average PM10, the rate of urolithiasis visits increased by 7% (95% CI: 1%, 13%). The magnitude of association between 3-day moving average PM10 and rate of urolithiasis visits increased with increasing MDT. The rate of asthma exacerbation significantly increased as 3-day, 7-day, and 21-day moving average PM10 increased. This retrospective study on ED visits is one of the first to investigate the impact of several environmental exposures on adverse health outcomes in a rural community. Research into mitigating the negative impacts of these environmental exposures on health outcomes is needed.

接触环境变量,包括空气质量下降和温度升高,可对人类健康产生有害影响,包括慢性疾病的急性恶化。我们的目的是调查这些暴露与科罗拉多州农村社区急性健康结果之间的关系。回顾性收集2013-2017年气象和成人急诊科就诊数据;对于哮喘结局,可获得额外数据(2003-2017年)。日环境暴露数据包括PM10、最高日温度(MDT)、平均湿度和降水量。计算研究期间急诊科(ED)诊断为心肌梗死、充血性心力衰竭、尿石症、慢性阻塞性肺疾病(COPD)和哮喘加重的每日总数。使用广义估计方程的时间序列模型适合每种疾病,并包括所有四个环境因素。2013年至2017年期间,哮喘和COPD加重分别占所有ED就诊人数的30.8%和25.4% (n= 5113)。我们发现,MDT每增加5˚C,尿石症就诊率增加13% (95% CI: 2%, 26%), 3天移动平均PM10每增加10μg/m3,尿石症就诊率增加7% (95% CI: 1%, 13%)。3天移动平均PM10与尿石症就诊率之间的关联程度随着MDT的增加而增加。随着3天、7天和21天移动平均PM10的增加,哮喘加重率显著增加。这项关于急诊科就诊的回顾性研究是首批调查农村社区几种环境暴露对不良健康结果影响的研究之一。需要研究如何减轻这些环境暴露对健康结果的负面影响。
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引用次数: 1
Considering Sun Safety Policies in the United States. 考虑到美国的太阳安全政策。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/FMWG8617
Fatima N Mirza, Humza N Mirza, Sara Yumeen, Cheryl K Zogg, David J Leffell

As they are collectively the most common malignancies, the personal and systemic burden of skin cancers represent a significant public health concern in the United States. Ultraviolet radiation from the sun as well as from artificial sources such as tanning beds is a carcinogen well-known to increase the risk of developing skin cancer in individuals. Public health policies can help mitigate these risks. In this perspectives article, we review sunscreen and sunglasses standards, tanning bed utilization, and workplace sun protection guidelines in the US and provide focused examples for improvement from Australia and the United Kingdom where skin cancer is a well-documented public health concern. These comparative examples can inform interventions in the US that have the potential to modify exposure to risk factors associated with skin cancer.

由于它们是最常见的恶性肿瘤,皮肤癌的个人和全身负担在美国是一个重要的公共卫生问题。来自太阳以及日光浴床等人造来源的紫外线辐射是一种致癌物质,众所周知,它会增加个人患皮肤癌的风险。公共卫生政策可以帮助减轻这些风险。在这篇观点文章中,我们回顾了美国的防晒霜和太阳镜标准、晒黑床的使用和工作场所防晒指南,并提供了澳大利亚和英国的重点改进案例,在这两个国家,皮肤癌是一个有充分记录的公共卫生问题。这些比较的例子可以为美国的干预措施提供信息,这些干预措施有可能改变与皮肤癌相关的危险因素的暴露。
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引用次数: 0
Eco-emotions and Psychoterratic Syndromes: Reshaping Mental Health Assessment Under Climate Change. 生态情绪与精神综合症:气候变化下重塑心理健康评估。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/EARX2427
Paolo Cianconi, Batul Hanife, Francesco Grillo, Sophia Betro', Cokorda Bagus Jaya Lesmana, Luigi Janiri

Human activities like greenhouse gas emissions, pollution, and deforestation are largely responsible for climate change and biodiversity loss. The climate is a complex system and scientists are striving to predict, prevent, and address the aforementioned issues in order to avoid reaching tipping points. The threat to humankind is not only physical (ie, heat waves, floods, droughts) but also psychological, especially for some groups. Insecurity, danger, chaos, and an unstable system due to climate change have both short- and long-term psychological effects. In this scenario, the need for new psychological categories is emerging, namely, eco-emotions and psychoterratic syndromes which include eco-anxiety, ecological grief, climate worry, and climate trauma. This paper focuses on these new categories, presenting a summary of each one, including definitions, hypotheses, questions, and testological evaluations, as a useful tool to be consulted by researchers and clinicians and to help them in the therapeutic work. Also, this paper endeavors to distinguish between a psychological stress resulting in a positive outcome, such as pro-environmental behavior, compared to a stress that leads to a psychopathology. Prevention and intervention strategies including social and community support are fundamental to help cope with and mitigate the effect of climate change on mental health. In conclusion, the climate crisis has led to an enormous increase in research on climate change and its consequences on mental health. Researchers and clinicians must be prepared to assess this complex phenomenon and provide help to those who cannot cope with anxiety and climatic mourning.

温室气体排放、污染和森林砍伐等人类活动是气候变化和生物多样性丧失的主要原因。气候是一个复杂的系统,科学家们正在努力预测、预防和解决上述问题,以避免达到临界点。对人类的威胁不仅是物理上的(即热浪、洪水、干旱),而且是心理上的,特别是对某些群体。气候变化带来的不安全、危险、混乱和不稳定的系统会产生短期和长期的心理影响。在这种情况下,对新的心理类别的需求正在出现,即生态情绪和精神综合症,包括生态焦虑、生态悲伤、气候担忧和气候创伤。本文重点介绍了这些新类别,并对每个类别进行了总结,包括定义、假设、问题和睾丸学评估,作为研究人员和临床医生参考和帮助他们进行治疗工作的有用工具。此外,本文试图区分导致积极结果(如亲环境行为)的心理压力与导致精神病理的压力之间的区别。包括社会和社区支持在内的预防和干预战略对于帮助应对和减轻气候变化对心理健康的影响至关重要。总之,气候危机导致对气候变化及其对心理健康影响的研究大幅增加。研究人员和临床医生必须做好评估这一复杂现象的准备,并为那些无法应对焦虑和气候哀悼的人提供帮助。
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引用次数: 2
The Climate Change Conversation: Understanding Nationwide Medical Education Efforts. 气候变化对话:了解全国医学教育的努力。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/PYIW9718
Olivia A Blanchard, Lucy M Greenwald, Perry E Sheffield

Despite increasing awareness of the public and global health ramifications of climate change, there is a lack of curricula discussing climate change within medical education. Where greater societal awareness and improved scientific understanding have begun to grab the attention of members of the medical education community, there is the precedent, the desire, and the need to incorporate climate-health topics into medical education. We hosted semi-structured interviews (n=9) with faculty members at different institutions across the country who have been involved with climate change education. We pursued a qualitative approach to begin an inter-institutional conversation and better understand what support our colleagues and peers need to expand climate-health education, and we identified a set of key barriers to implementation: Obtaining Institutional Resources, Formalizing Initiative Leadership, and Empowering Faculty Involvement. We also began to appreciate the creative strategies that programs across the country have employed to tackle these challenges. Working with interested students to manage workload, advocating for funded faculty positions, and integrating curricular materials in multiple formats are just a few of the approaches that have helped climate-health initiatives to achieve longevity and penetration in the curriculum. A better identification of the challenges and drivers for success in curricular efforts can provide a roadmap to more efficient implementation of climate-health topics within medical education.

尽管人们越来越认识到气候变化对公众和全球健康的影响,但在医学教育中缺乏讨论气候变化的课程。社会意识的提高和科学理解的提高已经开始引起医学教育界成员的注意,这是将气候健康主题纳入医学教育的先例、愿望和需要。我们主持了半结构化访谈(n=9),访谈对象是来自全国不同机构的从事气候变化教育的教职员工。我们采用定性方法开始机构间对话,更好地了解我们的同事和同行需要什么支持来扩大气候健康教育,我们确定了实施的一系列关键障碍:获得机构资源、正式确立倡议领导和授权教员参与。我们也开始欣赏全国各地的项目为应对这些挑战所采用的创造性策略。与感兴趣的学生合作管理工作量,倡导资助教师职位,以及以多种形式整合课程材料,这些方法只是帮助气候健康倡议在课程中实现长寿和渗透的一些方法。更好地确定课程努力取得成功的挑战和驱动因素,可以为在医学教育中更有效地实施气候健康主题提供路线图。
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引用次数: 0
Changing Degrees: Incorporating the Impacts of Climate Change on Health into Pediatric Residency Education and Practice. 变化的程度:将气候变化对健康的影响纳入儿科住院医师教育和实践。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/BSGY1262
Sophia J Gauthier

The American Academy of Pediatrics (AAP) was the first major medical society to release a policy statement on the impacts of climate change on pediatric health. It is estimated that globally, children bear the burden of climate-induced disease. However, many undergraduate and graduate medical curricula do not cover this topic. This article builds on previous literature to propose a framework for such a curriculum as well as justify its relevance in light of current accreditation requirements. Some curricular topics include extreme heat and heat-related injury, degradations in air quality and pediatric respiratory disease, spread of vector-borne and diarrheal illness, and mental health effects. Lastly, it addresses clinical applications for this knowledge, including screening vulnerable patients, offering anticipatory guidance, and advocating for the medical benefits of planetary health.

美国儿科学会(AAP)是第一个就气候变化对儿科健康的影响发布政策声明的主要医学协会。据估计,在全球范围内,儿童承受着气候引起的疾病的负担。然而,许多本科和研究生医学课程没有涵盖这个主题。本文建立在以前的文献提出这样的课程框架,并证明其相关性在目前的认证要求的光。一些课程主题包括极端高温和与热相关的伤害,空气质量和儿科呼吸系统疾病的恶化,媒介传播和腹泻疾病的传播,以及心理健康的影响。最后,它讨论了这方面知识的临床应用,包括筛查弱势患者、提供预期指导和倡导地球健康的医疗效益。
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引用次数: 0
Palliative Justice Post-COP27. cop27后的姑息司法。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/RTYB9681
William E Rosa, Liz Grant

The climate crisis is a planetary existential threat, disproportionately affecting the poorest populations worldwide. People in low- and middle-income countries (LMICs) experience the most detrimental consequences of climate injustice, endangering their livelihoods, safety, overall wellbeing, and survival. Although the 2022 United Nations Climate Change Conference (COP27) put forth several internationally salient recommendations, the outcomes fall short to efficiently tackle the suffering that exists at the intersection of social and climate injustice. Individuals with serious illness living in LMICs have the highest burden of health-related suffering globally. In fact, more than 61 million people experience serious health-related suffering (SHS) each year that is amenable to palliative care. Despite this well-documented burden of SHS, an estimated 88-90% of palliative care need is unmet, the majority in LMICs. To equitably address suffering at individual, population, and planetary levels in LMICs, a palliative justice approach is crucial. The interplay of human and planetary suffering requires that current planetary health recommendations be expanded to incorporate a whole-person and whole-people perspective that recognizes the need for environmentally conscious and community-based research and policy initiatives. Conversely, palliative care efforts should incorporate planetary health considerations to ensure sustainability in capacity building and service provision. In sum, the optimal health of the planet will remain elusive until we can holistically recognize the value of relieving all suffering due to life-limiting conditions, as well as the value in preserving the natural resources of countries in which all people are born, live, age, suffer, die, and grieve.

气候危机是全球生存的威胁,对全球最贫困人口的影响尤为严重。低收入和中等收入国家(LMICs)的人民受到气候不公正的最不利影响,危及他们的生计、安全、整体福祉和生存。尽管2022年联合国气候变化大会(COP27)提出了几项国际上突出的建议,但其成果未能有效解决社会和气候不公正交叉存在的痛苦。在全球范围内,低收入中低收入国家的重病患者与健康相关的痛苦负担最重。事实上,每年有6100多万人遭受与健康相关的严重痛苦,可以接受姑息治疗。尽管有充分的证据表明,SHS的负担,但估计88-90%的姑息治疗需求未得到满足,其中大多数在中低收入国家。为了公平地解决中低收入国家个人、人口和全球层面的痛苦,采取治标不治本的司法方法至关重要。人类和地球痛苦的相互作用要求扩大目前的地球健康建议,纳入全人和全体人民的观点,认识到需要有环境意识和基于社区的研究和政策举措。相反,姑息治疗工作应纳入全球健康考虑,以确保能力建设和服务提供的可持续性。总而言之,除非我们能够全面认识到减轻生命限制条件造成的所有痛苦的价值,以及保护所有人在其中出生、生活、衰老、受苦、死亡和悲伤的国家的自然资源的价值,否则地球的最佳健康状况将仍然难以实现。
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引用次数: 0
Promoting Sustainability Practices in the Outpatient Pediatric Setting. 促进可持续性实践在门诊儿科设置。
IF 2.7 3区 工程技术 Q2 BIOLOGY Pub Date : 2023-06-01 DOI: 10.59249/VCAH6394
Yuhyun McKenzie Yun, Caroline Kirby, Natalie Bob, Casey Calabria, Ashley Hernandez, Barbara Cook, Janet Krolczyk, Sandra H Jee

Healthcare systems intend to address health needs of a community, but unfortunately may also inadvertently exacerbate the climate crisis through increased greenhouse gas (GHG) emissions. Clinical medicine has not evolved to promote sustainability practices. New attention to the enormous impact of healthcare systems on GHG emissions and an escalating climate crisis has resulted in some institutions taking proactive measures to mitigate these negative effects. Some healthcare systems have made large-scale changes to conserve energy and materials, resulting in significant monetary savings. In this paper, we share our experience with developing an interdisciplinary work "green" team within our outpatient general pediatrics practice to implement changes, albeit small, to reduce our workplace carbon footprint. We share our experience with reducing paper usage by consolidating vaccine information sheets into a single use information sheet with quick response (QR) codes. We also share ideas for all workplaces to raise awareness of sustainability practices and to foster new ideas to address the climate crisis in both our professional and personal realms. These can help promote hope for the future and shift the collective mindset about climate action.

卫生保健系统旨在解决一个社区的卫生需求,但不幸的是,它也可能通过增加温室气体(GHG)排放而无意中加剧气候危机。临床医学尚未发展到促进可持续性实践。人们对医疗保健系统对温室气体排放和不断升级的气候危机的巨大影响的新关注,导致一些机构采取积极措施来减轻这些负面影响。一些医疗保健系统已经进行了大规模的改变,以节省能源和材料,从而节省了大量的资金。在本文中,我们分享了我们在门诊普通儿科实践中发展跨学科工作“绿色”团队的经验,以实施微小的变化,以减少我们工作场所的碳足迹。我们分享了通过将疫苗信息表合并为带有快速反应码的一次性信息表来减少纸张使用量的经验。我们还与所有工作场所分享想法,以提高对可持续发展实践的认识,并在我们的专业和个人领域培养应对气候危机的新想法。这些有助于促进对未来的希望,并改变对气候行动的集体心态。
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引用次数: 0
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