首页 > 最新文献

Geohealth最新文献

英文 中文
Mitigating Toxic Metal Exposure Through Leafy Greens: A Comprehensive Review Contrasting Cadmium and Lead in Spinach 通过绿叶蔬菜缓解有毒金属暴露:菠菜中的镉和铅对比综述》。
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-06-17 DOI: 10.1029/2024GH001081
Angelia L. Seyfferth, Matt A. Limmer, Benjamin R. K. Runkle, Rufus L. Chaney

Metals and metalloids (hereafter, metal(loid)s) in plant-based foods are a source of exposure to humans, but not all metal(loid)-food interactions are the same. Differences exist between metal(loid)s in terms of their behavior in soils and in how they are taken up by plants and stored in the edible plant tissue/food. Thus, there cannot be one consistent solution to reducing toxic metal(loid)s exposure to humans from foods. In addition, how metal(loid)s are absorbed, distributed, metabolized, and excreted by the human body differs based on both the metal(loid), other elements and nutrients in the food, and the nutritional status of the human. Initiatives like the United States Food and Drug Administration's Closer to Zero initiative to reduce the exposure of young children to the toxic elements cadmium, lead, arsenic, and mercury from foods warrant careful consideration of each metal(loid) and plant interaction. This review explores such plant-metal(loid) interactions using the example of spinach and the metals cadmium and lead. This review highlights differences in the magnitude of exposure, bioavailability, and the practicality of mitigation strategies while outlining research gaps and future needs. A focus on feasibility and producer needs, informed via stakeholder interviews, emphasizes the need for better analytical testing facilities and grower and consumer education. More research should focus on minimization of chloride inputs for leafy greens to lessen plant-availability of Cd and the role of oxalate in reducing Cd bioavailability from spinach. These findings are applicable to other leafy greens (e.g., kale, lettuce), but not for other plants or metal(loid)s.

植物性食品中的金属和类金属(以下简称 "金属(loid)")是人类的一个暴露源,但并非所有金属(loid)与食品之间的相互作用都是相同的。不同的金属(loid)在土壤中的行为以及被植物吸收并储存在可食用植物组织/食物中的方式都存在差异。因此,要减少人类从食物中摄入有毒金属元素,不可能有一个统一的解决方案。此外,食物中的金属、其他元素和营养物质以及人体的营养状况不同,人体对金属的吸收、分布、代谢和排泄方式也不同。美国食品和药物管理局提出的 "接近零 "计划旨在减少幼儿从食物中摄入有毒元素镉、铅、砷和汞。本综述以菠菜和金属镉、铅为例,探讨了植物与金属(loid)之间的相互作用。本综述强调了暴露程度、生物利用率和缓解策略实用性方面的差异,同时概述了研究缺口和未来需求。通过对利益相关者的访谈,重点了解了可行性和生产者的需求,强调需要更好的分析测试设施以及种植者和消费者教育。更多的研究应侧重于最大限度地减少绿叶菜中氯化物的摄入量,以降低镉的植物利用率,以及草酸盐在降低菠菜中镉的生物利用率方面的作用。这些发现适用于其他绿叶蔬菜(如羽衣甘蓝、莴苣),但不适用于其他植物或金属(loid)。
{"title":"Mitigating Toxic Metal Exposure Through Leafy Greens: A Comprehensive Review Contrasting Cadmium and Lead in Spinach","authors":"Angelia L. Seyfferth,&nbsp;Matt A. Limmer,&nbsp;Benjamin R. K. Runkle,&nbsp;Rufus L. Chaney","doi":"10.1029/2024GH001081","DOIUrl":"10.1029/2024GH001081","url":null,"abstract":"<p>Metals and metalloids (hereafter, metal(loid)s) in plant-based foods are a source of exposure to humans, but not all metal(loid)-food interactions are the same. Differences exist between metal(loid)s in terms of their behavior in soils and in how they are taken up by plants and stored in the edible plant tissue/food. Thus, there cannot be one consistent solution to reducing toxic metal(loid)s exposure to humans from foods. In addition, how metal(loid)s are absorbed, distributed, metabolized, and excreted by the human body differs based on both the metal(loid), other elements and nutrients in the food, and the nutritional status of the human. Initiatives like the United States Food and Drug Administration's Closer to Zero initiative to reduce the exposure of young children to the toxic elements cadmium, lead, arsenic, and mercury from foods warrant careful consideration of each metal(loid) and plant interaction. This review explores such plant-metal(loid) interactions using the example of spinach and the metals cadmium and lead. This review highlights differences in the magnitude of exposure, bioavailability, and the practicality of mitigation strategies while outlining research gaps and future needs. A focus on feasibility and producer needs, informed via stakeholder interviews, emphasizes the need for better analytical testing facilities and grower and consumer education. More research should focus on minimization of chloride inputs for leafy greens to lessen plant-availability of Cd and the role of oxalate in reducing Cd bioavailability from spinach. These findings are applicable to other leafy greens (e.g., kale, lettuce), but not for other plants or metal(loid)s.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 6","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guidelines for Managing Radon Hazards in Tourist Volcanic Caves in Spain 西班牙旅游火山洞穴氡危害管理指南
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-06-14 DOI: 10.1029/2024GH001067
Luis E. Hernández-Gutiérrez, Carlos Calderón-Guerrero, Wenceslao Martín-Rosales, Jesica Rodríguez-Martín, Noelia Cruz-Pérez, Helena Hernández-Martín, Alejandro García-Gil, Juan C. Santamarta

Tourist volcanic caves are in high demand for ecotourism and geotourism lovers, as well as by sun and beach tourists as a complementary activity during their holidays. There are six tourist volcanic caves in the Canary Islands, all of them managed by the local administration of the island. The managers of these caves must ensure the safety of visitors and workers, who are exposed to natural hazards, such as radon, inherent to the environment in which the activity takes place. The methodology for analyzing natural radon radiation is based on the latest studies published by experts in this field and on previous experiences in tourist caves. This article proposes a protocol for the correct management of radon in tourist caves in the Canary Islands, adapted to current regulations, to mitigate effects on the health of visitors and workers.

火山旅游洞穴是生态旅游和地质旅游爱好者的热门选择,也是阳光和海滩游客的度假补充活动。加那利群岛有六个火山旅游洞穴,均由当地政府管理。这些洞穴的管理者必须确保游客和工作人员的安全,因为他们暴露在活动环境固有的氡等自然危害中。分析天然氡辐射的方法是以该领域专家发表的最新研究成果和以往在旅游洞穴中的经验为基础的。本文根据现行法规,提出了正确管理加那利群岛旅游洞穴中氡的方案,以减轻对游客和工作人员健康的影响。
{"title":"Guidelines for Managing Radon Hazards in Tourist Volcanic Caves in Spain","authors":"Luis E. Hernández-Gutiérrez,&nbsp;Carlos Calderón-Guerrero,&nbsp;Wenceslao Martín-Rosales,&nbsp;Jesica Rodríguez-Martín,&nbsp;Noelia Cruz-Pérez,&nbsp;Helena Hernández-Martín,&nbsp;Alejandro García-Gil,&nbsp;Juan C. Santamarta","doi":"10.1029/2024GH001067","DOIUrl":"https://doi.org/10.1029/2024GH001067","url":null,"abstract":"<p>Tourist volcanic caves are in high demand for ecotourism and geotourism lovers, as well as by sun and beach tourists as a complementary activity during their holidays. There are six tourist volcanic caves in the Canary Islands, all of them managed by the local administration of the island. The managers of these caves must ensure the safety of visitors and workers, who are exposed to natural hazards, such as radon, inherent to the environment in which the activity takes place. The methodology for analyzing natural radon radiation is based on the latest studies published by experts in this field and on previous experiences in tourist caves. This article proposes a protocol for the correct management of radon in tourist caves in the Canary Islands, adapted to current regulations, to mitigate effects on the health of visitors and workers.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 6","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal Dynamics of COVID-19 Pandemic City Lockdown: Insights From Nighttime Light Remote Sensing COVID-19 大流行城市封锁的时空动态:夜间光线遥感的启示
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-06-06 DOI: 10.1029/2024GH001034
Luguang Jiang, Ye Liu

The global COVID-19 outbreak severely hampered the growth of the global economy, prompting the implementation of the strictest prevention policies in China. Establishing a significant relationship between changes in nighttime light and COVID-19 lockdowns from a geospatial perspective is essential. In light of nighttime light remote sensing, we evaluated the spatiotemporal dynamic effects of COVID-19 city lockdowns on human activity intensity in the Zhengzhou region. Prior to the COVID-19 outbreak, nighttime light in the Zhengzhou region maintained a significant growth trend, even under regular control measures. However, following the October 2022 COVID-19 lockdown, nighttime light experienced a substantial decrease. In the central area of Zhengzhou, nighttime light decreased by at least 18% compared to pre-lockdown levels, while in the sub-center, the decrease was around 14%. The areas where nighttime light decreased the most in the central region were primarily within a 15 km radius, while in the sub-center, the decrease was concentrated within a 5 km radius. These changes in both statistical data and nighttime light underscored the significant impact of the COVID-19 lockdown on economic activities in the Zhengzhou region.

COVID-19 在全球的爆发严重阻碍了全球经济的增长,促使中国实施了最严格的预防政策。从地理空间角度确定夜间光照变化与 COVID-19 封锁之间的重要关系至关重要。根据夜间光照遥感,我们评估了 COVID-19 城市封锁对郑州地区人类活动强度的时空动态影响。在 COVID-19 爆发之前,即使在常规控制措施下,郑州地区的夜间光照也保持着显著的增长趋势。然而,在 2022 年 10 月 COVID-19 封锁之后,夜间光照出现了大幅下降。与封锁前相比,郑州中心区的夜间光照至少减少了 18%,而副中心区的夜间光照减少了约 14%。中心区夜间光照减少最多的区域主要集中在 15 公里半径范围内,而副中心的夜间光照减少主要集中在 5 公里半径范围内。这些统计数据和夜间光照的变化凸显了 COVID-19 封锁对郑州地区经济活动的重大影响。
{"title":"Spatiotemporal Dynamics of COVID-19 Pandemic City Lockdown: Insights From Nighttime Light Remote Sensing","authors":"Luguang Jiang,&nbsp;Ye Liu","doi":"10.1029/2024GH001034","DOIUrl":"https://doi.org/10.1029/2024GH001034","url":null,"abstract":"<p>The global COVID-19 outbreak severely hampered the growth of the global economy, prompting the implementation of the strictest prevention policies in China. Establishing a significant relationship between changes in nighttime light and COVID-19 lockdowns from a geospatial perspective is essential. In light of nighttime light remote sensing, we evaluated the spatiotemporal dynamic effects of COVID-19 city lockdowns on human activity intensity in the Zhengzhou region. Prior to the COVID-19 outbreak, nighttime light in the Zhengzhou region maintained a significant growth trend, even under regular control measures. However, following the October 2022 COVID-19 lockdown, nighttime light experienced a substantial decrease. In the central area of Zhengzhou, nighttime light decreased by at least 18% compared to pre-lockdown levels, while in the sub-center, the decrease was around 14%. The areas where nighttime light decreased the most in the central region were primarily within a 15 km radius, while in the sub-center, the decrease was concentrated within a 5 km radius. These changes in both statistical data and nighttime light underscored the significant impact of the COVID-19 lockdown on economic activities in the Zhengzhou region.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 6","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Inverted U-Shaped Relationship Between Socio-Economic Status and Infections During the COVID-19 Pandemic COVID-19 大流行期间社会经济地位与感染之间的倒 U 型关系
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-05-23 DOI: 10.1029/2024GH001025
Yelin Sun, Weihang Liu, Gangfeng Zhang, Peijun Shi

Although the World Health Organization has declared that the COVID-19 pandemic no longer qualifies as a global public health emergency, it still needs to explore the response of society to the COVID-19 pandemic. Socio-economic status (SES) was proven to be linearly associated with the COVID-19 pandemic, although this relationship may be more complex due to regional differences. In the study, we analyzed and revealed the effects and mechanisms of SES on infections among low, lower-middle, upper-middle and high SES group (LSG, LMSG, UMSG, and HSG, respectively). The results showed that the relationship between SES and infections was inverted U-shaped, especially in the first three phases. In Phase I, UMSG had the highest number of infections, with an average of 238.31/1M people (95%CI: 135.47–341.15/1M people). In Phases II and III, infections decreased insignificantly with increasing SES (r = −0.01, p = 0.92; r = −0.11, p = 0.22) and the highest number of infections were found in the LMSG. In Phase IV, SES was positively related to the number of infections (r = 0.54, p < 0.001). Furthermore, the nonlinear impact of multiple factors related to SES on the infections explains the complex relationships between SES and infections. SES affected infections mainly through medical resources, demographics and vaccination, and differed across the SES groups. Particularly, demographics could exert an impact on population mobility, subsequently influencing infections in LMSG, with an indirect effect of 0.01 (p < 0.05) in Phase II. This study argues for greater attention to countries with middle SES and the need for future targeted measures to cope with infectious diseases.

尽管世界卫生组织已宣布 COVID-19 大流行不再属于全球公共卫生紧急事件,但仍需探讨社会对 COVID-19 大流行的反应。事实证明,社会经济地位(SES)与 COVID-19 大流行呈线性关系,但由于地区差异,这种关系可能更为复杂。在这项研究中,我们分析并揭示了社会经济地位对低、中低、中高和高社会经济地位群体(分别为 LSG、LMSG、UMSG 和 HSG)感染的影响和机制。结果显示,SES 与感染之间的关系呈倒 U 型,尤其是在前三个阶段。在第一阶段,UMSG 的感染人数最高,平均为 238.31/1M 人(95%CI:135.47-341.15/1M 人)。在第二和第三阶段,随着社会经济地位的提高,感染人数的下降并不明显(r = -0.01,p = 0.92;r = -0.11,p = 0.22),而感染人数最多的是 LMSG。在第四阶段,社会经济地位与感染人数呈正相关(r = 0.54,p = 0.001)。此外,与社会经济地位有关的多种因素对感染的非线性影响解释了社会经济地位与感染之间的复杂关系。社会经济地位主要通过医疗资源、人口统计学和疫苗接种来影响感染,并且在不同的社会经济地位组别之间存在差异。特别是,人口统计学会对人口流动产生影响,进而影响 LMSG 的感染率,在第二阶段的间接影响为 0.01(p < 0.05)。这项研究表明,应更加关注中等社会经济地位的国家,未来需要采取有针对性的措施来应对传染病。
{"title":"The Inverted U-Shaped Relationship Between Socio-Economic Status and Infections During the COVID-19 Pandemic","authors":"Yelin Sun,&nbsp;Weihang Liu,&nbsp;Gangfeng Zhang,&nbsp;Peijun Shi","doi":"10.1029/2024GH001025","DOIUrl":"https://doi.org/10.1029/2024GH001025","url":null,"abstract":"<p>Although the World Health Organization has declared that the COVID-19 pandemic no longer qualifies as a global public health emergency, it still needs to explore the response of society to the COVID-19 pandemic. Socio-economic status (SES) was proven to be linearly associated with the COVID-19 pandemic, although this relationship may be more complex due to regional differences. In the study, we analyzed and revealed the effects and mechanisms of SES on infections among low, lower-middle, upper-middle and high SES group (LSG, LMSG, UMSG, and HSG, respectively). The results showed that the relationship between SES and infections was inverted U-shaped, especially in the first three phases. In Phase I, UMSG had the highest number of infections, with an average of 238.31/1M people (95%CI: 135.47–341.15/1M people). In Phases II and III, infections decreased insignificantly with increasing SES (<i>r</i> = −0.01, <i>p</i> = 0.92; <i>r</i> = −0.11, <i>p</i> = 0.22) and the highest number of infections were found in the LMSG. In Phase IV, SES was positively related to the number of infections (<i>r</i> = 0.54, <i>p</i> &lt; 0.001). Furthermore, the nonlinear impact of multiple factors related to SES on the infections explains the complex relationships between SES and infections. SES affected infections mainly through medical resources, demographics and vaccination, and differed across the SES groups. Particularly, demographics could exert an impact on population mobility, subsequently influencing infections in LMSG, with an indirect effect of 0.01 (<i>p</i> &lt; 0.05) in Phase II. This study argues for greater attention to countries with middle SES and the need for future targeted measures to cope with infectious diseases.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 5","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141085080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cumulative Exposures to Environmental and Socioeconomic Risk Factors in Milwaukee County, Wisconsin 威斯康星州密尔沃基县环境和社会经济风险因素累积暴露情况
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-05-06 DOI: 10.1029/2023GH000927
John K. Kodros, Ellison Carter, Oluwatobi Oke, Ander Wilson, Shantanu H. Jathar, Sheryl Magzamen

The environmental justice literature demonstrates consistently that low-income and minority communities are disproportionately exposed to environmental hazards. In this case study, we examined cumulative multipollutant, multidomain, and multimatrix environmental exposures in Milwaukee County, Wisconsin for the year 2015. We identified spatial hot spots in Milwaukee County both individually (using local Moran's I) and through clusters (using K-means clustering) across a profile of environmental pollutants that span regulatory domains and matrices of exposure, as well as socioeconomic indicators. The cluster with the highest exposures within the urban area was largely characterized by low socioeconomic status and an overrepresentation of the Non-Hispanic Black population relative to the county as a whole. In this cluster, average pollutant concentrations were equivalent to the 78th percentile in county-level blood lead levels, 67th percentile in county-level NO2, 79th percentile in county-level CO, and 78th percentile in county-level air toxics. Simultaneously, this cluster had an average equivalent to the 62nd percentile in county-level unemployment, 70th percentile in county-level population rate lacking a high school diploma, 73rd percentile in county-level poverty rate, and 28th percentile in county-level median household income. The spatial patterns of pollutant exposure and SES indicators suggested that these disparities were not random but were instead structured by socioeconomic and racial factors. Our case study, which combines environmental pollutant exposures, sociodemographic data, and clustering analysis, provides a roadmap to identify and target overburdened communities for interventions that reduce environmental exposures and consequently improve public health.

环境正义文献一致表明,低收入和少数民族社区暴露于环境危害的比例过高。在本案例研究中,我们研究了威斯康星州密尔沃基县 2015 年累积的多污染物、多领域和多矩阵环境暴露。我们通过跨监管领域和暴露矩阵的环境污染物概况以及社会经济指标,单独(使用当地莫兰 I)和通过聚类(使用 K 均值聚类)确定了密尔沃基县的空间热点。城区内暴露量最高的聚类主要特征是社会经济地位较低,非西班牙裔黑人人口比例高于全县人口比例。在该群组中,平均污染物浓度相当于县级血铅水平的第 78 个百分位数、县级二氧化氮水平的第 67 个百分位数、县级一氧化碳水平的第 79 个百分位数以及县级空气有毒物质水平的第 78 个百分位数。同时,该群组的平均水平相当于县级失业率第 62 个百分位数、县级无高中文凭人口比例第 70 个百分位数、县级贫困率第 73 个百分位数和县级家庭收入中位数第 28 个百分位数。污染物暴露和社会经济地位指标的空间模式表明,这些差异并非随机的,而是由社会经济和种族因素造成的。我们的案例研究结合了环境污染物暴露、社会人口数据和聚类分析,为识别和针对负担过重的社区采取干预措施提供了路线图,从而减少环境暴露,进而改善公众健康。
{"title":"Cumulative Exposures to Environmental and Socioeconomic Risk Factors in Milwaukee County, Wisconsin","authors":"John K. Kodros,&nbsp;Ellison Carter,&nbsp;Oluwatobi Oke,&nbsp;Ander Wilson,&nbsp;Shantanu H. Jathar,&nbsp;Sheryl Magzamen","doi":"10.1029/2023GH000927","DOIUrl":"https://doi.org/10.1029/2023GH000927","url":null,"abstract":"<p>The environmental justice literature demonstrates consistently that low-income and minority communities are disproportionately exposed to environmental hazards. In this case study, we examined cumulative multipollutant, multidomain, and multimatrix environmental exposures in Milwaukee County, Wisconsin for the year 2015. We identified spatial hot spots in Milwaukee County both individually (using local Moran's I) and through clusters (using K-means clustering) across a profile of environmental pollutants that span regulatory domains and matrices of exposure, as well as socioeconomic indicators. The cluster with the highest exposures within the urban area was largely characterized by low socioeconomic status and an overrepresentation of the Non-Hispanic Black population relative to the county as a whole. In this cluster, average pollutant concentrations were equivalent to the 78th percentile in county-level blood lead levels, 67th percentile in county-level NO<sub>2</sub>, 79th percentile in county-level CO, and 78th percentile in county-level air toxics. Simultaneously, this cluster had an average equivalent to the 62nd percentile in county-level unemployment, 70th percentile in county-level population rate lacking a high school diploma, 73rd percentile in county-level poverty rate, and 28th percentile in county-level median household income. The spatial patterns of pollutant exposure and SES indicators suggested that these disparities were not random but were instead structured by socioeconomic and racial factors. Our case study, which combines environmental pollutant exposures, sociodemographic data, and clustering analysis, provides a roadmap to identify and target overburdened communities for interventions that reduce environmental exposures and consequently improve public health.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 5","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2023GH000927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the Rising Stars of GeoHealth 地理健康新星介绍
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-04-26 DOI: 10.1029/2024GH001053
Thanh H. Nguyen

Early career researchers often asked me: how I became the editor-in-chief, what editors, associate editors, and editors do, why I wanted to become an editor, how much time an editor committed, would I rather spend more time on my research and publish another paper or my personal life? All of these questions make sense. When I started as an assistant professor nearly 20 years ago, I did not plan to become an editor; I wanted to do my research and teach to achieve tenure. Sound familiar? Fortunately, I was gradually pulled into the publishing process not as an author but as a reviewer, associate editor, and eventually editor-in-chief by several senior colleagues, for whom I am forever grateful. Now, it is my turn to prepare the next generation of editors, the backbone of science.

初入职场的研究人员经常问我:我是怎么当上主编的,编辑、副主编和主编是做什么的,我为什么想当编辑,编辑要投入多少时间,我是愿意花更多时间在研究和发表论文上,还是愿意花更多时间在个人生活上?所有这些问题都是有道理的。将近 20 年前,当我开始担任助理教授时,我并没有打算成为一名编辑;我想做我的研究和教学,以获得终身教职。听起来很熟悉吧?幸运的是,我不是作为作者,而是作为审稿人、副主编,最终被几位资深同事拉进了出版流程,我永远感激他们。现在,轮到我来培养下一代编辑--科学界的中坚力量了。
{"title":"Introducing the Rising Stars of GeoHealth","authors":"Thanh H. Nguyen","doi":"10.1029/2024GH001053","DOIUrl":"https://doi.org/10.1029/2024GH001053","url":null,"abstract":"<p>Early career researchers often asked me: how I became the editor-in-chief, what editors, associate editors, and editors do, why I wanted to become an editor, how much time an editor committed, would I rather spend more time on my research and publish another paper or my personal life? All of these questions make sense. When I started as an assistant professor nearly 20 years ago, I did not plan to become an editor; I wanted to do my research and teach to achieve tenure. Sound familiar? Fortunately, I was gradually pulled into the publishing process not as an author but as a reviewer, associate editor, and eventually editor-in-chief by several senior colleagues, for whom I am forever grateful. Now, it is my turn to prepare the next generation of editors, the backbone of science.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 5","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fecal Bacteria Contamination of Floodwaters and a Coastal Waterway From Tidally-Driven Stormwater Network Inundation 潮汐驱动的暴雨网络淹没造成的洪水和沿海水道的粪便细菌污染
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-04-23 DOI: 10.1029/2024GH001020
M. M. Carr, A. C. Gold, A. Harris, K. Anarde, M. Hino, N. Sauers, G. Da Silva, C. Gamewell, N. G. Nelson

Inundation of coastal stormwater networks by tides is widespread due to sea-level rise (SLR). The water quality risks posed by tidal water rising up through stormwater infrastructure (pipes and catch basins), out onto roadways, and back out to receiving water bodies is poorly understood but may be substantial given that stormwater networks are a known source of fecal contamination. In this study, we (a) documented temporal variation in concentrations of Enterococcus spp. (ENT), the fecal indicator bacteria standard for marine waters, in a coastal waterway over a 2-month period and more intensively during two perigean spring tide periods, (b) measured ENT concentrations in roadway floodwaters during tidal floods, and (c) explained variation in ENT concentrations as a function of tidal inundation, antecedent rainfall, and stormwater infrastructure using a pipe network inundation model and robust linear mixed effect models. We find that ENT concentrations in the receiving waterway vary as a function of tidal stage and antecedent rainfall, but also site-specific characteristics of the stormwater network that drains to the waterway. Tidal variables significantly explain measured ENT variance in the waterway, however, runoff drove higher ENT concentrations in the receiving waterway. Samples of floodwaters on roadways during both perigean spring tide events were limited, but all samples exceeded the threshold for safe public use of recreational waters. These results indicate that inundation of stormwater networks by tides could pose public health hazards in receiving water bodies and on roadways, which will likely be exacerbated in the future due to continued SLR.

由于海平面上升(SLR),沿海雨水管网被潮水淹没的现象非常普遍。潮水通过雨水基础设施(管道和集水池)上升,流向道路,再返回到受纳水体,这对水质造成的风险尚不清楚,但鉴于雨水网络是已知的粪便污染源,其风险可能很大。在这项研究中,我们(a) 记录了沿海水道中的肠球菌属 (ENT) 浓度(海洋水域的粪便指示细菌标准)在两个月内的时间变化,并在两次近地春潮期间进行了更深入的研究;(b) 在潮汐洪水期间测量了道路洪水中的 ENT 浓度;(c) 使用管网淹没模型和稳健线性混合效应模型解释了 ENT 浓度的变化与潮汐淹没、前降雨量和雨水基础设施的函数关系。我们发现,受纳水道中的 ENT 浓度不仅与潮汐阶段和前期降雨量有关,还与排入水道的雨水管网的具体地点特征有关。潮汐变量可以很好地解释水道中测得的 ENT 差异,但径流会导致受纳水道中的 ENT 浓度更高。在两次近地春潮事件中,道路上的洪水样本有限,但所有样本都超过了公众安全使用娱乐水域的阈值。这些结果表明,潮汐对雨水网络的淹没可能会对受纳水体和道路上的公共健康造成危害,而由于持续的可持续土地上升,这种危害在未来可能会更加严重。
{"title":"Fecal Bacteria Contamination of Floodwaters and a Coastal Waterway From Tidally-Driven Stormwater Network Inundation","authors":"M. M. Carr,&nbsp;A. C. Gold,&nbsp;A. Harris,&nbsp;K. Anarde,&nbsp;M. Hino,&nbsp;N. Sauers,&nbsp;G. Da Silva,&nbsp;C. Gamewell,&nbsp;N. G. Nelson","doi":"10.1029/2024GH001020","DOIUrl":"https://doi.org/10.1029/2024GH001020","url":null,"abstract":"<p>Inundation of coastal stormwater networks by tides is widespread due to sea-level rise (SLR). The water quality risks posed by tidal water rising up through stormwater infrastructure (pipes and catch basins), out onto roadways, and back out to receiving water bodies is poorly understood but may be substantial given that stormwater networks are a known source of fecal contamination. In this study, we (a) documented temporal variation in concentrations of <i>Enterococcus</i> spp. (ENT), the fecal indicator bacteria standard for marine waters, in a coastal waterway over a 2-month period and more intensively during two perigean spring tide periods, (b) measured ENT concentrations in roadway floodwaters during tidal floods, and (c) explained variation in ENT concentrations as a function of tidal inundation, antecedent rainfall, and stormwater infrastructure using a pipe network inundation model and robust linear mixed effect models. We find that ENT concentrations in the receiving waterway vary as a function of tidal stage and antecedent rainfall, but also site-specific characteristics of the stormwater network that drains to the waterway. Tidal variables significantly explain measured ENT variance in the waterway, however, runoff drove higher ENT concentrations in the receiving waterway. Samples of floodwaters on roadways during both perigean spring tide events were limited, but all samples exceeded the threshold for safe public use of recreational waters. These results indicate that inundation of stormwater networks by tides could pose public health hazards in receiving water bodies and on roadways, which will likely be exacerbated in the future due to continued SLR.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 4","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to Smoke From Wildfire, Prescribed, and Agricultural Burns Among At-Risk Populations Across Washington, Oregon, and California 华盛顿州、俄勒冈州和加利福尼亚州高危人群暴露于野火、规定烧毁和农业烧毁烟雾的情况
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-04-22 DOI: 10.1029/2023GH000961
C. L. Schollaert, M. E. Marlier, J. D. Marshall, J. T. Spector, T. Busch Isaksen

Wildfires, prescribed burns, and agricultural burns all impact ambient air quality across the Western U.S.; however, little is known about how communities across the region are differentially exposed to smoke from each of these fire types. To address this gap, we quantify smoke exposure stemming from wildfire, prescribed, and agricultural burns across Washington, Oregon, and California from 2014 to 2020 using a fire type-specific biomass burning emissions inventory and the GEOS-Chem chemical transport model. We examine fire type-specific PM2.5 concentration by race/ethnicity, socioeconomic status, and in relation to the Center for Disease Control's Social Vulnerability Index. Overall, population-weighted PM2.5 concentrations are greater from wildfires than from prescribed and from agricultural burns. While we found limited evidence of exposure disparities among sub-groups across the full study area, we did observe disproportionately higher exposures to wildfire-specific PM2.5 exposures among Native communities in all three states and, in California, higher agricultural burn-specific PM2.5 exposures among lower socioeconomic groups. We also identified, for all three states, areas of significant spatial clustering of smoke exposures from all fire types and increased social vulnerability. These results provide a first look at the differential contributions of smoke from wildfires, prescribed burns, and agricultural burns to PM2.5 exposures among demographic subgroups, which can be used to inform more tailored exposure reduction strategies across sources.

野火、规定的燃烧和农业焚烧都会影响美国西部的环境空气质量;然而,人们对整个地区的社区如何不同程度地暴露于这些火灾类型产生的烟雾却知之甚少。为了填补这一空白,我们使用特定火灾类型的生物质燃烧排放清单和 GEOS-Chem 化学传输模型,量化了 2014 年至 2020 年华盛顿州、俄勒冈州和加利福尼亚州的野火、规定烧荒和农业烧荒产生的烟雾暴露。我们按种族/人种、社会经济状况以及疾病控制中心的社会脆弱性指数对特定火灾类型的 PM2.5 浓度进行了研究。总体而言,野火产生的人口加权 PM2.5 浓度要高于处方焚烧和农业焚烧产生的 PM2.5 浓度。虽然我们在整个研究区域内发现的亚群体间暴露差异的证据有限,但我们确实观察到在所有三个州的原住民社区中,野火特有的 PM2.5 暴露过高,而在加利福尼亚州,社会经济地位较低的群体中,农业焚烧特有的 PM2.5 暴露较高。我们还发现,在所有三个州中,所有火灾类型造成的烟雾暴露都有明显的空间聚集区域,社会脆弱性也有所增加。这些结果首次揭示了野火、规定焚烧和农业焚烧产生的烟雾在不同人口亚群中对 PM2.5 暴露的不同贡献,这些结果可用于制定更有针对性的减少各种来源暴露的策略。
{"title":"Exposure to Smoke From Wildfire, Prescribed, and Agricultural Burns Among At-Risk Populations Across Washington, Oregon, and California","authors":"C. L. Schollaert,&nbsp;M. E. Marlier,&nbsp;J. D. Marshall,&nbsp;J. T. Spector,&nbsp;T. Busch Isaksen","doi":"10.1029/2023GH000961","DOIUrl":"https://doi.org/10.1029/2023GH000961","url":null,"abstract":"<p>Wildfires, prescribed burns, and agricultural burns all impact ambient air quality across the Western U.S.; however, little is known about how communities across the region are differentially exposed to smoke from each of these fire types. To address this gap, we quantify smoke exposure stemming from wildfire, prescribed, and agricultural burns across Washington, Oregon, and California from 2014 to 2020 using a fire type-specific biomass burning emissions inventory and the GEOS-Chem chemical transport model. We examine fire type-specific PM<sub>2.5</sub> concentration by race/ethnicity, socioeconomic status, and in relation to the Center for Disease Control's Social Vulnerability Index. Overall, population-weighted PM<sub>2.5</sub> concentrations are greater from wildfires than from prescribed and from agricultural burns. While we found limited evidence of exposure disparities among sub-groups across the full study area, we did observe disproportionately higher exposures to wildfire-specific PM<sub>2.5</sub> exposures among Native communities in all three states and, in California, higher agricultural burn-specific PM<sub>2.5</sub> exposures among lower socioeconomic groups. We also identified, for all three states, areas of significant spatial clustering of smoke exposures from all fire types and increased social vulnerability. These results provide a first look at the differential contributions of smoke from wildfires, prescribed burns, and agricultural burns to PM<sub>2.5</sub> exposures among demographic subgroups, which can be used to inform more tailored exposure reduction strategies across sources.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 4","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2023GH000961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Selenium and Cadmium on Human Liver and Kidney Functions in Exposed Black Shale Areas 硒和镉对黑页岩暴露区人体肝肾功能的影响
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-04-21 DOI: 10.1029/2024GH001040
Minglong Li, Liang Qiu, Xunru Ai, Keyuan Xu, Min Peng, Guogen Sun, Kai Zhang, Chuying Huang

Animal experiments suggest that selenium (Se) may alleviate cadmium (Cd) toxicity in animal liver and kidneys, but its effect on human liver and kidneys remains uncertain. In China, areas with black shale have shown elevated levels of Se and Cd. According to the USEPA (U.S. Environmental Protection Agency) evaluation method, the soil and rice in these areas pose significant risks. In black shale regions such as Enshi and Zhuxi County, residents who long-term consume local rice may surpass safe Se and Cd intake levels. Significantly high median blood Se (B-Se) and urine selenium (U-Se) levels were detected in these areas, measuring 416.977 μg/L and 352.690 μg/L and 104.527 μg/L and 51.820 μg/L, respectively. Additionally, the median blood Cd (B-Cd) and urine Cd (U-Cd) levels were markedly elevated at 4.821 μg/L and 3.848 μg/L and at 7.750 μg/L and 7.050 μg/L, respectively, indicating substantial Cd exposure. Nevertheless, sensitive liver and kidney biomarkers in these groups fall within healthy reference ranges, suggesting a potential antagonistic effect of Se on Cd in the human body. Therefore, the USEPA method may not accurately assess Cd risk in exposed black shale areas. However, within the healthy ranges, residents in the Enshi study area had significantly greater median levels of serum creatinine and cystatin C, measuring 67.3 μmol/L and 0.92 mg/L, respectively, than those in Zhuxi did (53.6 μmol/L and 0.86 mg/L). In cases of excessive Se and Cd exposure, high Se and Cd levels impact the filtration function of the human kidney to some extent.

动物实验表明,硒(Se)可减轻镉(Cd)对动物肝脏和肾脏的毒性,但其对人体肝脏和肾脏的影响仍不确定。在中国,黑页岩地区的硒和镉含量都有所升高。根据美国环保署(USEPA)的评估方法,这些地区的土壤和水稻具有重大风险。在恩施州和竹溪县等黑页岩地区,长期食用当地大米的居民的硒和镉摄入量可能会超过安全水平。这些地区的血硒(B-Se)和尿硒(U-Se)含量中位数明显偏高,分别为 416.977 μg/L 和 352.690 μg/L 以及 104.527 μg/L 和 51.820 μg/L。此外,血液镉(B-Cd)和尿液镉(U-Cd)水平的中位数也明显升高,分别为 4.821 μg/L 和 3.848 μg/L,以及 7.750 μg/L 和 7.050 μg/L,表明镉暴露量很大。不过,这些群体中敏感的肝脏和肾脏生物标志物都在健康参考值范围内,这表明硒在人体内对镉有潜在的拮抗作用。因此,美国环保局的方法可能无法准确评估黑页岩暴露区的镉风险。不过,在健康范围内,恩施研究区居民血清肌酐和胱抑素 C 的中位数水平明显高于竹溪居民(分别为 67.3 μmol/L 和 0.92 mg/L)(53.6 μmol/L 和 0.86 mg/L)。在过量接触硒和镉的情况下,高水平的硒和镉会在一定程度上影响人体肾脏的过滤功能。
{"title":"Effects of Selenium and Cadmium on Human Liver and Kidney Functions in Exposed Black Shale Areas","authors":"Minglong Li,&nbsp;Liang Qiu,&nbsp;Xunru Ai,&nbsp;Keyuan Xu,&nbsp;Min Peng,&nbsp;Guogen Sun,&nbsp;Kai Zhang,&nbsp;Chuying Huang","doi":"10.1029/2024GH001040","DOIUrl":"https://doi.org/10.1029/2024GH001040","url":null,"abstract":"<p>Animal experiments suggest that selenium (Se) may alleviate cadmium (Cd) toxicity in animal liver and kidneys, but its effect on human liver and kidneys remains uncertain. In China, areas with black shale have shown elevated levels of Se and Cd. According to the USEPA (U.S. Environmental Protection Agency) evaluation method, the soil and rice in these areas pose significant risks. In black shale regions such as Enshi and Zhuxi County, residents who long-term consume local rice may surpass safe Se and Cd intake levels. Significantly high median blood Se (B-Se) and urine selenium (U-Se) levels were detected in these areas, measuring 416.977 μg/L and 352.690 μg/L and 104.527 μg/L and 51.820 μg/L, respectively. Additionally, the median blood Cd (B-Cd) and urine Cd (U-Cd) levels were markedly elevated at 4.821 μg/L and 3.848 μg/L and at 7.750 μg/L and 7.050 μg/L, respectively, indicating substantial Cd exposure. Nevertheless, sensitive liver and kidney biomarkers in these groups fall within healthy reference ranges, suggesting a potential antagonistic effect of Se on Cd in the human body. Therefore, the USEPA method may not accurately assess Cd risk in exposed black shale areas. However, within the healthy ranges, residents in the Enshi study area had significantly greater median levels of serum creatinine and cystatin C, measuring 67.3 μmol/L and 0.92 mg/L, respectively, than those in Zhuxi did (53.6 μmol/L and 0.86 mg/L). In cases of excessive Se and Cd exposure, high Se and Cd levels impact the filtration function of the human kidney to some extent.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 4","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2024GH001040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Common Mechanisms of Cytotoxicity Induced by Organophosphorus Pesticides via NLRP3 Inflammasome Activation 有机磷农药通过 NLRP3 炎症小体激活诱导细胞毒性的潜在共同机制
IF 4.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-04-18 DOI: 10.1029/2023GH000888
Xiaoning Wang, Xin Sui, Yangyang Sun, Ziqi Cui, Ning Ma, Shuai Wang, Jun Yang, Fengying Liu, Weijie Yang, Zhenyu Xiao, Tong Zhu, Yuan Luo, Yongan Wang

The Multi-Threat Medical Countermeasure (MTMC) technique is crucial for developing common biochemical signaling pathways, molecular mediators, and cellular processes. This study revealed that the Nod-like receptor 3 (NLRP3) inflammasome pathway may be a significant contributor to the cytotoxicity induced by various organophosphorus pesticides (OPPs). The study demonstrated that exposure to six different types of OPPs (paraoxon, dichlorvos, fenthion, dipterex, dibrom, and dimethoate) led to significant cytotoxicity in BV2 cells, which was accompanied by increased expression of NLRP3 inflammasome complexes (NLRP3, ASC, Caspase-1) and downstream inflammatory cytokines (IL-1β, IL-18), in which the order of cytotoxicity was dichlorvos > dipterex > dibrom > paraoxon > fenthion > dimethoate, based on the IC50 values of 274, 410, 551, 585, 2,158, and 1,527,566 μM, respectively. The findings suggest that targeting the NLRP3 inflammasome pathway could be a potential approach for developing broad-spectrum antitoxic drugs to combat multi-OPPs-induced toxicity. Moreover, inhibition of NLRP3 efficiently protected the cells against cytotoxicity induced by these six OPPs, and the expression of NLRP3, ASC, Caspase-1, IL-1β, and IL-18 decreased accordingly. The order of NLRP3 affinity for OPPs was dimethoate > paraoxon > dichlorvos > dibrom > (fenthion and dipterex) based on KD values of 89.8, 325, 1,460, and 2,690 μM, respectively. Furthermore, the common molecular mechanism of NLRP3-OPPs was clarified by the presence of toxicity effector groups (benzene ring, nitrogen/oxygen-containing functional group); =O, -O-, or =S (active) groups; and combination residues (Gly271, Asp272). This finding provided valuable insights into exploring the common mechanisms of multiple threats and developing effective therapeutic strategies to prevent OPPs poisoning.

多重威胁医学对策(MTMC)技术对于开发常见的生化信号通路、分子介质和细胞过程至关重要。这项研究发现,类Nod受体3(NLRP3)炎性体通路可能是各种有机磷农药(OPPs)诱导细胞毒性的重要因素。研究表明,暴露于六种不同类型的有机磷农药(敌百虫、敌敌畏、倍硫磷、敌克松、二溴磷和乐果)会导致BV2细胞出现显著的细胞毒性,并伴随着NLRP3炎性体复合物(NLRP3、ASC、Caspase-1)和下游炎性细胞因子(IL-1β、IL-18)表达的增加,其中细胞毒性的顺序为敌敌畏、敌敌畏、敌克松、二溴磷和乐果;IC50值分别为274、410、551、585、2,158和1,527,566 μM。研究结果表明,以 NLRP3 炎性体通路为靶点可能是开发广谱抗毒药物的一种潜在方法,以对抗多种OPPs 引起的毒性。此外,抑制NLRP3能有效保护细胞免受这六种OPPs诱导的细胞毒性,NLRP3、ASC、Caspase-1、IL-1β和IL-18的表达也相应减少。根据KD值(分别为89.8、325、1,460和2,690 μM),NLRP3与OPPs的亲和力依次为乐果、对硫磷、敌敌畏、敌百虫和倍硫磷(倍硫磷和敌克松)。此外,通过毒性效应基团(苯环、含氮/氧官能团)、=O、-O-或=S(活性)基团以及组合残基(Gly271、Asp272)的存在,阐明了 NLRP3-OPPs 的共同分子机制。这一发现为探索多种威胁的共同机制和开发有效的治疗策略以预防 OPPs 中毒提供了宝贵的见解。
{"title":"Potential Common Mechanisms of Cytotoxicity Induced by Organophosphorus Pesticides via NLRP3 Inflammasome Activation","authors":"Xiaoning Wang,&nbsp;Xin Sui,&nbsp;Yangyang Sun,&nbsp;Ziqi Cui,&nbsp;Ning Ma,&nbsp;Shuai Wang,&nbsp;Jun Yang,&nbsp;Fengying Liu,&nbsp;Weijie Yang,&nbsp;Zhenyu Xiao,&nbsp;Tong Zhu,&nbsp;Yuan Luo,&nbsp;Yongan Wang","doi":"10.1029/2023GH000888","DOIUrl":"https://doi.org/10.1029/2023GH000888","url":null,"abstract":"<p>The Multi-Threat Medical Countermeasure (MTMC) technique is crucial for developing common biochemical signaling pathways, molecular mediators, and cellular processes. This study revealed that the Nod-like receptor 3 (NLRP3) inflammasome pathway may be a significant contributor to the cytotoxicity induced by various organophosphorus pesticides (OPPs). The study demonstrated that exposure to six different types of OPPs (paraoxon, dichlorvos, fenthion, dipterex, dibrom, and dimethoate) led to significant cytotoxicity in BV2 cells, which was accompanied by increased expression of NLRP3 inflammasome complexes (NLRP3, ASC, Caspase-1) and downstream inflammatory cytokines (IL-1β, IL-18), in which the order of cytotoxicity was dichlorvos &gt; dipterex &gt; dibrom &gt; paraoxon &gt; fenthion &gt; dimethoate, based on the IC<sub>50</sub> values of 274, 410, 551, 585, 2,158, and 1,527,566 μM, respectively. The findings suggest that targeting the NLRP3 inflammasome pathway could be a potential approach for developing broad-spectrum antitoxic drugs to combat multi-OPPs-induced toxicity. Moreover, inhibition of NLRP3 efficiently protected the cells against cytotoxicity induced by these six OPPs, and the expression of NLRP3, ASC, Caspase-1, IL-1β, and IL-18 decreased accordingly. The order of NLRP3 affinity for OPPs was dimethoate &gt; paraoxon &gt; dichlorvos &gt; dibrom &gt; (fenthion and dipterex) based on <i>K</i><sub><i>D</i></sub> values of 89.8, 325, 1,460, and 2,690 μM, respectively. Furthermore, the common molecular mechanism of NLRP3-OPPs was clarified by the presence of toxicity effector groups (benzene ring, nitrogen/oxygen-containing functional group); =O, -O-, or =S (active) groups; and combination residues (Gly271, Asp272). This finding provided valuable insights into exploring the common mechanisms of multiple threats and developing effective therapeutic strategies to prevent OPPs poisoning.</p>","PeriodicalId":48618,"journal":{"name":"Geohealth","volume":"8 4","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1029/2023GH000888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140606286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Geohealth
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1