This paper studies the humanitarian supply transportation problem in post-disaster scenarios under uncertainty, which employs a truck-drone collaborative delivery to efficiently meet relief demands. We focus on the vehicle routing problem with drones (VRPD), in which each truck carries multiple drones that can independently deliver supplies to several affected areas during a single sortie and return to the truck at designated retrieval points for recharging. Unlike drones, which operate with stable flight times, trucks are subject to uncertain travel times due to post-disaster disruptions. The goal is to minimize both total delivery time and overall travel cost. To solve this complex problem, we propose a bi-objective metaheuristic combining Adaptive Large Neighborhood Search (ALNS) with ϵ-dominance within a multi-objective simulated annealing framework (AMOSA). The performance of the proposed method was evaluated by comparison with NSGA-II, MOEA/D and SPEA2, a state-of-the-art multi-objective optimization algorithm. Experiments were based on real-world data from the Kartal district of Turkey. Results show that the multi-visit mode can effectively reduce drone routes compared to the single-visit mode, especially as truck capacity increases. The importance of considering uncertainty is demonstrated by analyzing the impact of key uncertain parameters on the resulting solutions and by performing out-of-sample testing. Furthermore, we investigate how varying the number of drones and their flight range influence transportation system performance.
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