The vehicle routing problem with pickup and delivery (VRPPD) is concerned with planning optimal routes for a fleet of vehicles to meet the diverse demands of customers. In this problem, scenarios involving either simultaneous pickup and delivery (SPD) or mixed pickup and delivery (MPD) cause fluctuations in vehicle loads. Our theoretical analyses reveal that SPD tightens vehicle capacity constraints, reducing the number of feasible solutions, while MPD expands the feasible region, thus increasing the number of local optima. This necessitates a generic algorithm to balance diversification and intensification and to promote persistent exploration. Therefore, this paper considers multiple neighborhood scales and proposes a consensus-based estimation of distribution algorithm (EDA) incorporating the scalable large neighborhood search (SLNS) and the tour fragment recombination (TFR), abbreviated as CEDA-ST. In the CEDA-ST, population consensus is leveraged to estimate the distribution of optimal routes, generating a consensus matrix for individual construction and neighborhood searches. The SLNS operator conducts destroy-and-repair moves in large neighborhoods to promote diversification. Meanwhile, the TFR operator facilitates local improvements in small neighborhoods to enhance intensification. Furthermore, a stagnation-triggered diversity management (STDM) strategy is developed to eliminate redundant individuals, encouraging persistent exploration. Comparative experiments demonstrate its superiority. An effectiveness analysis and two ablation experiments highlight the contributions of consensus information and multi-scale neighborhood search, respectively. Additionally, a real-world case study on JD Logistics further validates the applicability of CEDA-ST in practical scenarios.
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