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Comparison of Endoscopic Radiofrequency Ablation and Argon Plasma Coagulation in Patients with Gastric Low-Grade Intraepithelial Neoplasia: A Large-Scale Retrospective Study. 胃低级别上皮内瘤变的内镜射频消融与氩等离子凝固的比较:一项大规模回顾性研究。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-22 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2349940
Nanjun Wang, Ningli Chai, Longsong Li, Huikai Li, Yaqi Zhai, Xiuxue Feng, Shengzhen Liu, Wengang Zhang, Enqiang Linghu

Background: Gastric low-grade intraepithelial neoplasia (LGIN) is a precancerous lesion of gastric cancer. Endoscopic therapies represented by radiofrequency ablation (RFA) and argon plasma coagulation (APC) have been applied to treat gastric LGIN in recent years. However, no comparative study examining the effectiveness and safety profiles of RFA and APC has been reported.

Methods: A single-center, large-scale, retrospective study, including 73 and 50 patients treated with RFA and APC, respectively, was conducted in the First Medical Center of Chinese PLA General Hospital from October 2015 to October 2020, with a two-year follow-up. Effectiveness, complications, operative factors, and other data were assessed.

Results: At 2 years of follow-up, cure, relapse, recurrence, and progression rates were 90.4%, 9.6%, 9.6%, and 2.7% in the RFA group, respectively, versus 90%, 10%, 12%, and 4% in the APC group, respectively, with no statistically significant differences between the two groups (all p > 0.05). However, the mean lesion size was significantly larger in the RFA group (2.6 ± 1.0 cm) than in the APC group (1.5 ± 0.6 cm) (p < 0.001); there was also a significant difference in the composition ratio of large lesions between the two groups (p < 0.001). No serious postoperative complications showed in either group, and the abdominal pain was the most common symptom in the short term after surgery.

Conclusions: RFA and APC are both safe and effective destructive therapies for gastric LGIN. RFA is more suitable for flat and large lesions, while APC is more suitable for small lesions, especially those with slight local uplift or depression. An intraoperative submucosal injection is expected to be an effective method for relieving postoperative abdominal pain.

背景:胃低级别上皮内瘤变(LGIN)是胃癌的癌前病变。近年来,以射频消融(RFA)和氩等离子凝固(APC)为代表的内镜治疗已被应用于胃LGIN的治疗。然而,目前还没有关于RFA和APC的有效性和安全性的比较研究报道。方法:选取2015年10月至2020年10月在中国人民解放军总医院第一医学中心分别接受RFA和APC治疗的患者73例和50例,采用单中心、大规模、回顾性研究,随访2年。评估疗效、并发症、手术因素及其他数据。结果:随访2年时,RFA组的治愈率、复发率、复发率、进展率分别为90.4%、9.6%、9.6%、2.7%,APC组的治愈率分别为90%、10%、12%、4%,两组间差异无统计学意义(p > 0.05)。RFA组的平均病灶大小(2.6±1.0 cm)明显大于APC组(1.5±0.6 cm) (p < 0.001);两组间大病灶组成比例也有显著差异(p < 0.001)。两组均未出现严重的术后并发症,术后短期内腹痛是最常见的症状。结论:RFA和APC均是安全有效的胃LGIN破坏性治疗方法。RFA更适合扁平、大的病灶,APC更适合小的病灶,尤其是局部有轻微隆起或凹陷的病灶。术中粘膜下注射有望成为缓解术后腹痛的有效方法。
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引用次数: 0
Risk Factors and Timing of Additional Surgery after Noncurative ESD for Early Gastric Cancer. 早期胃癌无治愈性ESD后追加手术的危险因素及时机。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3421078
Kaipeng Duan, Dongbao Li, Dongtao Shi, Jie Pei, Jiayu Ren, Weikang Li, Anqi Dong, Tao Chen, Jin Zhou

Background: Patients with early gastric cancer undergoing noncurative endoscopic submucosal dissection (ESD) have a risk of tumor recurrence and metastasis, and some patients need additional surgery. The purpose of this study was to explore the risk factors of cancer residue and lymph node (LN) metastasis after noncurative ESD for early gastric cancer and to compare the short outcome of early and delayed additional surgery.

Methods: The clinicopathological characteristics of 30 early gastric cancer patients who received noncurative ESD and additional surgery were studied retrospectively. Multivariable regression was utilized to examine the independent risk factors for residual cancer and LN metastasis. Receiver operating characteristic curve was used to analyze the multivariable model's predictive performance. Furthermore, the perioperative safety and radical tumor performance of early surgery (≤30 days, n = 11), delayed surgery (>30 days, n = 11) after ESD, and upfront surgery (n = 59) were compared.

Results: Multivariable regression showed that diffuse type of Lauren classification, submucosal invasion, and positive human epidermal growth factor receptor-2 (HER-2) were risk factors for residual cancer. Undifferentiated carcinoma, vascular invasion, and positive vertical margin were risk factors for LN metastasis. The area under the curve (AUC) of the multifactor model predicting cancer residue and LN metastasis was 0.761 and 0.792, respectively. The early surgery group experienced higher intraoperative blood loss and a longer operation time than the delayed surgery and upfront surgery groups. There was no significant difference in the number of LN dissections, LN metastasis rate, and postoperative complications among the three groups.

Conclusion: Diffuse type of Lauren classification, submucosal invasion, and positive HER-2 are risk factors for residual cancer, while undifferentiated carcinoma, vascular invasion, and positive vertical margin are risk factors for LN metastasis. Delayed additional surgery after ESD (>30 days) has higher intraoperative safety, without affecting the radical resection in early gastric cancer patients.

背景:早期胃癌患者行内镜下粘膜下剥离术(ESD)有肿瘤复发和转移的风险,部分患者需要额外手术治疗。本研究的目的是探讨早期胃癌非治愈性ESD术后肿瘤残留和淋巴结转移的危险因素,并比较早期和延迟追加手术的短期预后。方法:回顾性分析30例早期胃癌患者的临床病理特点。采用多变量回归分析残余癌和淋巴结转移的独立危险因素。采用受试者工作特征曲线分析多变量模型的预测性能。比较ESD术后早期手术(≤30天,n = 11)、延迟手术(>30天,n = 11)和术前手术(n = 59)的围手术期安全性和肿瘤根治性表现。结果:多变量回归显示弥漫性Lauren分型、粘膜下浸润、人表皮生长因子受体2 (HER-2)阳性是残留癌发生的危险因素。未分化癌、血管浸润和垂直边缘阳性是淋巴结转移的危险因素。预测肿瘤残留和淋巴结转移的多因素模型的曲线下面积(AUC)分别为0.761和0.792。早期手术组术中出血量高于延迟手术组和术前手术组,手术时间较术前手术组长。三组在淋巴结清扫数、淋巴结转移率、术后并发症方面无显著差异。结论:Lauren弥漫性分型、粘膜下浸润、HER-2阳性是淋巴结残留癌的危险因素,未分化癌、血管浸润、垂缘阳性是淋巴结转移的危险因素。ESD后延迟追加手术(>30天)术中安全性更高,不影响早期胃癌患者根治性切除。
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引用次数: 1
Usefulness of Noncontrast MRI-Based Radiomics Combined Clinic Biomarkers in Stratification of Liver Fibrosis. 非对比mri放射组学联合临床生物标志物在肝纤维化分层中的应用。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2249447
Ru Zhao, Hong Zhao, Ya-Qiong Ge, Fang-Fang Zhou, Long-Sheng Wang, Hong-Zhen Yu, Xi-Jun Gong

Purpose: To develop and validate a radiomic nomogram based on texture features from out-of-phase T1W images and clinical biomarkers in prediction of liver fibrosis.

Materials and methods: Patients clinically diagnosed with chronic liver fibrosis who underwent liver biopsy and noncontrast MRI were enrolled. All patients were assigned to the nonsignificant fibrosis group with fibrosis stage <2 and the significant fibrosis group with stage ≥2. Texture parameters were extracted from out-of-phase T1-weighted (T1W) images and calculated using the Artificial Intelligent Kit (AK). Boruta and LASSO regressions were used for feature selection and a multivariable logistic regression was used for construction of a combinational model integrating radiomics and clinical biomarkers. The performance of the models was assessed by using the receiver operator curve (ROC) and decision curve.

Results: ROC analysis of the radiomics model that included the most discriminative features showed AUCs of the training and test groups were 0.80 and 0.78. A combinational model integrating RADscore and fibrosis 4 index was established. ROC analysis of the training and test groups showed good to excellent performance with AUC of 0.93 and 0.86. Decision curves showed the combinational model added more net benefit than radiomic and clinical models alone.

Conclusions: The study presents a combinational model that incorporates RADscore and clinical biomarkers, which is promising in classification of liver fibrosis.

目的:开发并验证基于异相T1W图像纹理特征和临床生物标志物预测肝纤维化的放射组学图。材料和方法:纳入临床诊断为慢性肝纤维化并行肝活检和非对比MRI检查的患者。结果:纳入最具鉴别特征的放射组学模型的ROC分析显示,训练组和试验组的auc分别为0.80和0.78。建立RADscore与纤维化指数的联合模型。训练组和试验组的ROC分析结果均为良好至优异,AUC分别为0.93和0.86。决策曲线显示,联合模型比单独的放射学和临床模型增加了更多的净效益。结论:该研究提出了一种结合RADscore和临床生物标志物的联合模型,在肝纤维化的分类中有前景。
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引用次数: 2
Antiviral Therapy for a Postpartum Flare in Women with Chronic HBV Infection Shortens the ALT Recovery Time and Reduces Hepatitis Re-Flare Rates within 4 years. 对慢性 HBV 感染妇女产后复发进行抗病毒治疗可缩短谷丙转氨酶恢复时间并降低 4 年内肝炎复发率。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4753267
Min Quan, Cong Liu, Wei Li, Hui-Chun Xing

Background: Few studies explored whether anti-hepatitis B virus (HBV) therapy should be initiated during postpartum hepatitis flare.

Aim: This study aimed to analyze the effect of anti-HBV therapy on postpartum hepatitis flare and evaluate the prognosis within 4 years postpartum.

Methods: This retrospective study enrolled hepatitis B surface antigen (HBsAg)-positive and hepatitis B e antigen (HBeAg)-positive pregnant women with HBV DNA ≥ 106 IU/mL. A total of 152 pregnant women were included: 103 in the prophylactic anti-HBV therapy group (PT-G) and 49 in the non-prophylactic anti-HBV therapy group (NPT-G). The women with a postpartum flare were assigned to the anti-HBV therapy group (AT-G) and non-anti-HBV therapy group (NAT-G) to analyze the effect of postpartum anti-HBV therapy on hepatitis flare. Virological and biochemical parameters were assessed.

Results: Taking postpartum 12 weeks as the cutoff point, the ALT recovered time for postpartum flare women is shorter in AT-G (n = 16, 42.1%) or PT-G (n = 23, 34.8%) than in NAT-G (n = 14, 23.0%; x 2 = 4.067, P=0.044) or NPT-G (n = 4, 11.1%; x 2 = 5.579, P=0.018). Taking postpartum 26 weeks as the cutoff point, the ALT recovered time is shorter in AT-G (n = 35, 57.3%) or PT-G (n = 44, 66.7%) than in NAT-G (n = 32, 84.2%; x 2 = 7.707, P=0.006) or NPT-G (n = 16, 44.4%; x 2 = 4.749, P=0.029). Postpartum flare recovery time was positively correlated with HBV DNA level at delivery [r = 0.223, P=0.025, 95%CI (0.022~0.41)]. The hepatitis re-flare rates within postpartum 4 years in AT-G (n = 3, 9.68%) is lower than that in NAT-G (n = 24, 45.4%; x 2 = 14.003, P ≤ 0.001). The HBeAg, HBsAg, HBV DNA, and ALT level at postpartum 4 years in AT-G were lower than that in NAT-G (P < 0.001).

Conclusion: Anti-HBV therapy for postpartum hepatitis flare of women with chronic HBV could shorten the ALT recovery time and reduce hepatitis re-flare rates within 4 years of postpartum.

背景:目的:本研究旨在分析抗HBV治疗对产后肝炎复发的影响,并评估产后4年内的预后情况:这项回顾性研究纳入了乙型肝炎表面抗原(HBsAg)阳性和乙型肝炎e抗原(HBeAg)阳性、HBV DNA≥106 IU/mL的孕妇。共纳入 152 名孕妇:预防性抗 HBV 治疗组(PT-G)103 人,非预防性抗 HBV 治疗组(NPT-G)49 人。产后复发的妇女被分配到抗 HBV 治疗组(AT-G)和非抗 HBV 治疗组(NAT-G),以分析产后抗 HBV 治疗对肝炎复发的影响。对病毒学和生化指标进行了评估:以产后 12 周为分界点,AT-G 组(n = 16,42.1%)或 PT-G 组(n = 23,34.8%)产后复发妇女的 ALT 恢复时间短于 NAT-G 组(n = 14,23.0%;x 2 = 4.067,P=0.044)或 NPT-G 组(n = 4,11.1%;x 2 = 5.579,P=0.018)。以产后 26 周为分界点,AT-G(35 人,57.3%)或 PT-G(44 人,66.7%)的 ALT 恢复时间短于 NAT-G(32 人,84.2%;x 2 = 7.707,P=0.006)或 NPT-G(16 人,44.4%;x 2 = 4.749,P=0.029)。产后复发时间与分娩时的 HBV DNA 水平呈正相关[r = 0.223,P=0.025,95%CI (0.022~0.41)]。AT-G 在产后 4 年内的肝炎复发率(n = 3,9.68%)低于 NAT-G(n = 24,45.4%;x 2 = 14.003,P ≤ 0.001)。AT-G产后4年的HBeAg、HBsAg、HBV DNA和ALT水平均低于NAT-G(P < 0.001):结论:对产后肝炎复发的慢性 HBV 妇女进行抗 HBV 治疗可缩短 ALT 恢复时间,降低产后 4 年内肝炎复发率。
{"title":"Antiviral Therapy for a Postpartum Flare in Women with Chronic HBV Infection Shortens the ALT Recovery Time and Reduces Hepatitis Re-Flare Rates within 4 years.","authors":"Min Quan, Cong Liu, Wei Li, Hui-Chun Xing","doi":"10.1155/2022/4753267","DOIUrl":"10.1155/2022/4753267","url":null,"abstract":"<p><strong>Background: </strong>Few studies explored whether anti-hepatitis B virus (HBV) therapy should be initiated during postpartum hepatitis flare.</p><p><strong>Aim: </strong>This study aimed to analyze the effect of anti-HBV therapy on postpartum hepatitis flare and evaluate the prognosis within 4 years postpartum.</p><p><strong>Methods: </strong>This retrospective study enrolled hepatitis B surface antigen (HBsAg)-positive and hepatitis B e antigen (HBeAg)-positive pregnant women with HBV DNA ≥ 10<sup>6</sup> IU/mL. A total of 152 pregnant women were included: 103 in the prophylactic anti-HBV therapy group (PT-G) and 49 in the non-prophylactic anti-HBV therapy group (NPT-G). The women with a postpartum flare were assigned to the anti-HBV therapy group (AT-G) and non-anti-HBV therapy group (NAT-G) to analyze the effect of postpartum anti-HBV therapy on hepatitis flare. Virological and biochemical parameters were assessed.</p><p><strong>Results: </strong>Taking postpartum 12 weeks as the cutoff point, the ALT recovered time for postpartum flare women is shorter in AT-G (<i>n</i> = 16, 42.1%) or PT-G (<i>n</i> = 23, 34.8%) than in NAT-G (<i>n</i> = 14, 23.0%; <i>x</i> <sup>2</sup> = 4.067, <i>P</i>=0.044) or NPT-G (<i>n</i> = 4, 11.1%; <i>x</i> <sup>2</sup> = 5.579, <i>P</i>=0.018). Taking postpartum 26 weeks as the cutoff point, the ALT recovered time is shorter in AT-G (<i>n</i> = 35, 57.3%) or PT-G (<i>n</i> = 44, 66.7%) than in NAT-G (<i>n</i> = 32, 84.2%; <i>x</i> <sup>2</sup> = 7.707, <i>P</i>=0.006) or NPT-G (<i>n</i> = 16, 44.4%; <i>x</i> <sup>2</sup> = 4.749, <i>P</i>=0.029). Postpartum flare recovery time was positively correlated with HBV DNA level at delivery [<i>r</i> = 0.223, <i>P</i>=0.025, 95%CI (0.022~0.41)]. The hepatitis re-flare rates within postpartum 4 years in AT-G (<i>n</i> = 3, 9.68%) is lower than that in NAT-G (<i>n</i> = 24, 45.4%; <i>x</i> <sup>2</sup> = 14.003, <i>P</i> ≤ 0.001). The HBeAg, HBsAg, HBV DNA, and ALT level at postpartum 4 years in AT-G were lower than that in NAT-G (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Anti-HBV therapy for postpartum hepatitis flare of women with chronic HBV could shorten the ALT recovery time and reduce hepatitis re-flare rates within 4 years of postpartum.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40406416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Modified Glasgow Prognostic Score Predicts Survival in Gastric Cancer Patients with Normal CEA and CA19-9. 改良格拉斯哥预后评分预测CEA和CA19-9正常胃癌患者的生存。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3953004
Shun Zhang, Jing-Ze Li, Tao Du, Hai-Qiang Li, Ren-Hao Hu, Chi-Ye Ma, Xi-Mao Cui, Chun Song, Xiao-Hua Jiang

Background: Traditionally, serum CEA and CA19-9 levels are good prognostic factors for gastric cancer. Many gastric cancer patients do not have elevated CEA or CA19-9 levels even at a very advanced stage. This study investigates the significance of the modified Glasgow prognostic score (mGPS) for the survival of gastric cancer patients with normal CEA and CA19-9.

Methods: We retrospectively examined 488 curatively resected gastric cancer patients with normal preoperative serum levels of CEA and CA19-9 to evaluate the prognostic ability of mGPS for overall survival. The prognostic significance was analyzed by univariate and multivariate analyses.

Results: Age, hemoglobin, white cell count, and neutrophils were each significantly correlated with the mGPS. Multivariate analyses showed that tumor location (HR, 0.803; 95% CI, 0.667-0.966; P=0.020), TNM stage (HR, 2.714; 95% CI, 2.250-3.275; P < 0.001), and mGPS (HR, 1.042; 95% CI, 1.105-1.772; P=0.023) were significantly associated with overall survival. Significant correlations were found between overall survival and mGPS. The Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0, 1, and 2 (P < 0.001), with the mortality rate being higher for patients with a higher mGPS.

Conclusion: The mGPS can predict survival in gastric cancer patients with normal CEA and CA19-9.

背景:传统上,血清CEA和CA19-9水平是胃癌预后的良好指标。许多胃癌患者即使在非常晚期也没有CEA或CA19-9水平升高。本研究探讨改良格拉斯哥预后评分(mGPS)对CEA和CA19-9正常胃癌患者生存的意义。方法:回顾性分析488例胃癌根治患者,术前血清CEA和CA19-9水平正常,评价mGPS对总生存期的预后能力。采用单因素和多因素分析对预后意义进行分析。结果:年龄、血红蛋白、白细胞计数、中性粒细胞与mGPS均有显著相关。多因素分析显示,肿瘤位置(HR, 0.803;95% ci, 0.667-0.966;P=0.020)、TNM分期(HR, 2.714;95% ci, 2.250-3.275;P < 0.001), mGPS (HR, 1.042;95% ci, 1.105-1.772;P=0.023)与总生存率显著相关。总生存率与mGPS之间存在显著相关性。Kaplan-Meier分析显示mGPS为0、1和2的患者之间存在显著差异(P < 0.001), mGPS较高的患者死亡率更高。结论:mGPS可预测CEA和CA19-9正常的胃癌患者的生存。
{"title":"The Modified Glasgow Prognostic Score Predicts Survival in Gastric Cancer Patients with Normal CEA and CA19-9.","authors":"Shun Zhang,&nbsp;Jing-Ze Li,&nbsp;Tao Du,&nbsp;Hai-Qiang Li,&nbsp;Ren-Hao Hu,&nbsp;Chi-Ye Ma,&nbsp;Xi-Mao Cui,&nbsp;Chun Song,&nbsp;Xiao-Hua Jiang","doi":"10.1155/2022/3953004","DOIUrl":"https://doi.org/10.1155/2022/3953004","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, serum CEA and CA19-9 levels are good prognostic factors for gastric cancer. Many gastric cancer patients do not have elevated CEA or CA19-9 levels even at a very advanced stage. This study investigates the significance of the modified Glasgow prognostic score (mGPS) for the survival of gastric cancer patients with normal CEA and CA19-9.</p><p><strong>Methods: </strong>We retrospectively examined 488 curatively resected gastric cancer patients with normal preoperative serum levels of CEA and CA19-9 to evaluate the prognostic ability of mGPS for overall survival. The prognostic significance was analyzed by univariate and multivariate analyses.</p><p><strong>Results: </strong>Age, hemoglobin, white cell count, and neutrophils were each significantly correlated with the mGPS. Multivariate analyses showed that tumor location (HR, 0.803; 95% CI, 0.667-0.966; <i>P</i>=0.020), TNM stage (HR, 2.714; 95% CI, 2.250-3.275; <i>P</i> < 0.001), and mGPS (HR, 1.042; 95% CI, 1.105-1.772; <i>P</i>=0.023) were significantly associated with overall survival. Significant correlations were found between overall survival and mGPS. The Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0, 1, and 2 (<i>P</i> < 0.001), with the mortality rate being higher for patients with a higher mGPS.</p><p><strong>Conclusion: </strong>The mGPS can predict survival in gastric cancer patients with normal CEA and CA19-9.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40225037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Application of Half-Transected and Self-Pulling Esophagojejunostomy in Total Laparoscopic Gastrectomy for Gastric Cancer: A Safe and Feasible Technique. 半截自拉食管空肠吻合术在腹腔镜胃癌全胃切除术中的应用:一种安全可行的技术。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2422274
Hongtao Wan, Jianyong Xiong, Yanglin Chen, Haiyun Wei, Ren Tang, Chao Chen, Qing Sun, Jing Xu, Bo Yi

Objective: This study introduces a technique for esophagojejunostomy with half transected and self-pulling (HTSP) and evaluates the safety, feasibility, and clinical results of this technique in totally laparoscopic total gastrectomy (TLTG).

Materials and methods: From May 2019 to March 2021, 42 patients (HTSP group) who underwent HTSP-TLTG surgery in the Department of Abdominal Tumor Surgery of Jiangxi Cancer Hospital were included in this study. The control group consisted of 50 patients undergoing conventional TLTG surgery (conventional anastomosis group) performed by the same surgical team from March 2018 to March 2020. The clinical data of the two groups were retrospectively analyzed and compared.

Results: The mean operation time of the HTSP-TLTG surgery was 166.7 ± 13.1 minutes and the anastomosis time was 20.8 ± 2.0 minutes, which were significantly shorter than those of traditional TLTG (P < 0.05). There were no significant differences between the two groups in blood loss, time to first exhaust, postoperative hospital stay, and incidence of surgery-related complications.

Conclusion: HTSP is a safe and feasible way of endoscopic esophagojejunal anastomosis, which requires a relatively low suture technique under endoscopy, and is suitable for promotion.

目的:介绍一种半截自拉食管空肠吻合术(HTSP),并评价该技术在全腹腔镜全胃切除术(TLTG)中的安全性、可行性及临床效果。材料与方法:选取2019年5月至2021年3月在江西省肿瘤医院腹部肿瘤外科行HTSP- tltg手术的患者42例(HTSP组)作为研究对象。对照组于2018年3月至2020年3月由同一手术团队进行常规TLTG手术(常规吻合组)的患者50例。回顾性分析比较两组患者的临床资料。结果:HTSP-TLTG手术平均手术时间为166.7±13.1分钟,吻合时间为20.8±2.0分钟,明显短于传统TLTG (P < 0.05)。两组在出血量、首次排气时间、术后住院时间和手术相关并发症发生率方面无显著差异。结论:HTSP是一种安全可行的内镜下食管空肠吻合方式,对内镜下缝合技术要求相对较低,适合推广。
{"title":"Application of Half-Transected and Self-Pulling Esophagojejunostomy in Total Laparoscopic Gastrectomy for Gastric Cancer: A Safe and Feasible Technique.","authors":"Hongtao Wan,&nbsp;Jianyong Xiong,&nbsp;Yanglin Chen,&nbsp;Haiyun Wei,&nbsp;Ren Tang,&nbsp;Chao Chen,&nbsp;Qing Sun,&nbsp;Jing Xu,&nbsp;Bo Yi","doi":"10.1155/2022/2422274","DOIUrl":"https://doi.org/10.1155/2022/2422274","url":null,"abstract":"<p><strong>Objective: </strong>This study introduces a technique for esophagojejunostomy with half transected and self-pulling (HTSP) and evaluates the safety, feasibility, and clinical results of this technique in totally laparoscopic total gastrectomy (TLTG).</p><p><strong>Materials and methods: </strong>From May 2019 to March 2021, 42 patients (HTSP group) who underwent HTSP-TLTG surgery in the Department of Abdominal Tumor Surgery of Jiangxi Cancer Hospital were included in this study. The control group consisted of 50 patients undergoing conventional TLTG surgery (conventional anastomosis group) performed by the same surgical team from March 2018 to March 2020. The clinical data of the two groups were retrospectively analyzed and compared.</p><p><strong>Results: </strong>The mean operation time of the HTSP-TLTG surgery was 166.7 ± 13.1 minutes and the anastomosis time was 20.8 ± 2.0 minutes, which were significantly shorter than those of traditional TLTG (<i>P</i> < 0.05). There were no significant differences between the two groups in blood loss, time to first exhaust, postoperative hospital stay, and incidence of surgery-related complications.</p><p><strong>Conclusion: </strong>HTSP is a safe and feasible way of endoscopic esophagojejunal anastomosis, which requires a relatively low suture technique under endoscopy, and is suitable for promotion.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40225038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Albumin Paclitaxel Compared with 5-Penfluorouracil, Lobaplatin, and Albumin Paclitaxel Combined with 5-Penfluorouracil in the Treatment of Human Gastric Cancer Cell AGS Line Autophagy and Apoptosis. 白蛋白紫杉醇与5-潘氟尿嘧啶、洛铂及白蛋白紫杉醇联合5-潘氟尿嘧啶治疗人胃癌AGS细胞自噬和凋亡的比较
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-10 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6015877
Xingzhen Cheng, Fang Yang, Yang Wang, Wei Nie, Adarsha Mahendra Upadhyay, Maolin Zhang, Qian Wang, Zhiqiang Yan

Background: Gastric cancer is one of the most common malignant tumors in the world. Albumin paclitaxel (Nab-PTX) is a novel microtubule inhibitor with albumin as the carrier. Several clinical trials are underway in gastric cancer, but the autophagy mechanism of Nab-PTX on gastric cancer is still unclear. The autophagy and apoptosis effects of Nab-PTX compared with 5-pentafluorouracil (5-Fu) and lobaplatin (LBP) in gastric cancer are also unclear.

Objective: This article will compare the effects of Nab-PTX, 5-Fu, LBP, and albumin paclitaxel + 5-pentafluorouracil (Nab-PTX + 5-Fu) on AGS cells from the perspective of autophagy and apoptosis, which is to provide new ideas and experimental evidence for gastric cancer.

Method: (1) Experimental groups were control (Ctrl), Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu. (2) CCK-8 assay was used to reflect cell viability and proliferation. (3) The flow cytometry was used to perform the 24-hour apoptosis and cell cycle of each group. (4) Western blot assay was used to investigate autophagy signal proteins LC3I/LC3II, LC3II/LC3I, SQSTM1/p62, Beclin-1, Atg12, Atg5, p-mULK1, p-AMPK, p-mTOR, and apoptosis signal proteins Bax and Bcl-2.

Results: Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu inhibited AGS cells' proliferation and arrested the cell cycle. At the same time, each group increased the apoptosis of AGS cells to various degrees (Nab-PTX + 5-Fu > Nab-PTX > 5-Fu > LBP, respectively). The experimental results showed that Nab-PTX and Nab-PTX + 5-Fu promoted autophagy and apoptosis of AGS cells. The comparison of Nab-PTX, 5-Fu, and LBP between groups revealed that 5-Fu inhibited autophagy and the expression of apoptosis protein Bax. In LBP, abnormal activation of autophagy downstream, blocking of autophagy flow, abnormal increase of ATG12, and increased expression of apoptosis protein Bax occurred. Further study found that the autophagy upstream mechanism is different.

Conclusion: Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu can inhibit cell proliferation, promote cell apoptosis, and induce the difference in autophagy expression. The autophagy difference of this antitumor drug may be related to its inducing apoptosis. Meanwhile, Nab-PTX has a better antitumor effect than 5-Fu and LBP in gastric cancer, and the combination of Nab-PTX + 5-Fu has more antitumor advantages.

背景:胃癌是世界上最常见的恶性肿瘤之一。白蛋白紫杉醇(Nab-PTX)是一种以白蛋白为载体的新型微管抑制剂。一些胃癌的临床试验正在进行中,但Nab-PTX对胃癌的自噬机制尚不清楚。与5-五氟尿嘧啶(5-Fu)和洛铂(LBP)相比,Nab-PTX在胃癌中的自噬和凋亡作用也尚不清楚。目的:本文将从自噬和凋亡的角度比较Nab-PTX、5-Fu、LBP和白蛋白紫杉醇+ 5-五氟尿嘧啶(Nab-PTX + 5-Fu)对胃癌细胞的影响,为胃癌治疗提供新的思路和实验依据。方法:(1)实验组为对照组(Ctrl)、Nab-PTX、5-Fu、LBP、Nab-PTX + 5-Fu。(2) CCK-8法反映细胞活力和增殖情况。(3)流式细胞术检测各组细胞24小时凋亡及细胞周期。(4) Western blot检测细胞自噬信号蛋白LC3I/LC3II、LC3II/LC3I、SQSTM1/p62、Beclin-1、Atg12、Atg5、p-mULK1、p-AMPK、p-mTOR、凋亡信号蛋白Bax、Bcl-2。结果:Nab-PTX、5-Fu、LBP和Nab-PTX + 5-Fu均能抑制AGS细胞的增殖,阻滞细胞周期。同时,各组均不同程度增加AGS细胞凋亡(分别为Nab-PTX + 5-Fu > Nab-PTX > 5-Fu > LBP)。实验结果显示,Nab-PTX和Nab-PTX + 5-Fu促进AGS细胞自噬和凋亡。各组间Nab-PTX、5-Fu和LBP的比较发现,5-Fu抑制细胞自噬和凋亡蛋白Bax的表达。在LBP中,自噬下游异常激活,自噬流动受阻,ATG12异常升高,凋亡蛋白Bax表达增加。进一步研究发现自噬上游机制不同。结论:Nab-PTX、5-Fu、LBP及Nab-PTX + 5-Fu均能抑制细胞增殖,促进细胞凋亡,诱导细胞自噬表达差异。这种抗肿瘤药物的自噬差异可能与其诱导细胞凋亡有关。同时,Nab-PTX在胃癌中的抗肿瘤作用优于5-Fu和LBP,且Nab-PTX + 5-Fu联合使用具有更强的抗肿瘤优势。
{"title":"Albumin Paclitaxel Compared with 5-Penfluorouracil, Lobaplatin, and Albumin Paclitaxel Combined with 5-Penfluorouracil in the Treatment of Human Gastric Cancer Cell AGS Line Autophagy and Apoptosis.","authors":"Xingzhen Cheng,&nbsp;Fang Yang,&nbsp;Yang Wang,&nbsp;Wei Nie,&nbsp;Adarsha Mahendra Upadhyay,&nbsp;Maolin Zhang,&nbsp;Qian Wang,&nbsp;Zhiqiang Yan","doi":"10.1155/2022/6015877","DOIUrl":"https://doi.org/10.1155/2022/6015877","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer is one of the most common malignant tumors in the world. Albumin paclitaxel (Nab-PTX) is a novel microtubule inhibitor with albumin as the carrier. Several clinical trials are underway in gastric cancer, but the autophagy mechanism of Nab-PTX on gastric cancer is still unclear. The autophagy and apoptosis effects of Nab-PTX compared with 5-pentafluorouracil (5-Fu) and lobaplatin (LBP) in gastric cancer are also unclear.</p><p><strong>Objective: </strong>This article will compare the effects of Nab-PTX, 5-Fu, LBP, and albumin paclitaxel + 5-pentafluorouracil (Nab-PTX + 5-Fu) on AGS cells from the perspective of autophagy and apoptosis, which is to provide new ideas and experimental evidence for gastric cancer.</p><p><strong>Method: </strong>(1) Experimental groups were control (Ctrl), Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu. (2) CCK-8 assay was used to reflect cell viability and proliferation. (3) The flow cytometry was used to perform the 24-hour apoptosis and cell cycle of each group. (4) Western blot assay was used to investigate autophagy signal proteins LC3I/LC3II, LC3II/LC3I, SQSTM1/p62, Beclin-1, Atg12, Atg5, p-mULK1, p-AMPK, p-mTOR, and apoptosis signal proteins Bax and Bcl-2.</p><p><strong>Results: </strong>Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu inhibited AGS cells' proliferation and arrested the cell cycle. At the same time, each group increased the apoptosis of AGS cells to various degrees (Nab-PTX + 5-Fu > Nab-PTX > 5-Fu > LBP, respectively). The experimental results showed that Nab-PTX and Nab-PTX + 5-Fu promoted autophagy and apoptosis of AGS cells. The comparison of Nab-PTX, 5-Fu, and LBP between groups revealed that 5-Fu inhibited autophagy and the expression of apoptosis protein Bax. In LBP, abnormal activation of autophagy downstream, blocking of autophagy flow, abnormal increase of ATG12, and increased expression of apoptosis protein Bax occurred. Further study found that the autophagy upstream mechanism is different.</p><p><strong>Conclusion: </strong>Nab-PTX, 5-Fu, LBP, and Nab-PTX + 5-Fu can inhibit cell proliferation, promote cell apoptosis, and induce the difference in autophagy expression. The autophagy difference of this antitumor drug may be related to its inducing apoptosis. Meanwhile, Nab-PTX has a better antitumor effect than 5-Fu and LBP in gastric cancer, and the combination of Nab-PTX + 5-Fu has more antitumor advantages.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40012227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Computed Tomography Images of Spontaneous Portosystemic Shunt in Liver Cirrhosis. 肝硬化自发性门静脉分流的计算机断层扫描图像
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3231144
Fangfang Yi, Xiaozhong Guo, Qing-Lei Zeng, Benqiang Yang, Yanglan He, Shanshan Yuan, Ankur Arora, Xingshun Qi

Spontaneous portosystemic shunt (SPSS) refers to collateral vessels that communicate between the portal vein system and systemic circulation. SPSS mainly includes esophageal varices, gastric varices, left gastric vein, recanalized paraumbilical vein, abdominal wall varices, and spontaneous splenorenal shunt. SPSS contributes to the development of hepatic encephalopathy caused by portal vein inflow bypassing and carries a higher risk of death in liver cirrhosis. Abdominal contrast-enhanced computed tomography is a major imaging approach to establish a diagnosis of SPSS and evaluate its location and feature. This review primarily describes the main contrast-enhanced CT features of SPSS in liver cirrhosis.

自发性门静脉分流(SPSS)是指门静脉系统与全身循环之间沟通的侧支血管。自发性门静脉分流主要包括食管静脉曲张、胃静脉曲张、胃左静脉、脐旁静脉再通、腹壁静脉曲张和自发性脾肾分流。自发性脾肾分流术会导致门静脉血流旁路引起的肝性脑病,并增加肝硬化患者的死亡风险。腹部造影剂增强计算机断层扫描是确定 SPSS 诊断、评估其位置和特征的主要成像方法。本综述主要介绍肝硬化 SPSS 的主要对比增强 CT 特征。
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引用次数: 0
Clostridioides difficile Infection in Liver Cirrhosis: A Concise Review 肝硬化难辨梭菌感染:简要综述
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-07 DOI: 10.1155/2022/4209442
Yuanbin Liu, Mingkai Chen
Clostridium difficile is a Gram-positive bacillus with fecal-oral transmission and is currently one of the most common nosocomial infections worldwide, which was renamed Clostridioides difficile in 2016. Clostridioides difficile infection (CDI) is a prevalent infection in cirrhosis and negatively affects prognosis. This study aimed to provide a concise review with clinical practice implications. The prevalence of CDI in cirrhotic patients increases, while the associated mortality decreases. Multiple groups of risk factors increase the likelihood of CDI in patients with cirrhosis, such as antibiotic use, the severity of cirrhosis, some comorbidities, and demographic aspects. Treatment in the general population is currently described in the latest guidelines. In patients with cirrhosis, rifaximin and lactulose have been shown to reduce CDI risk due to their modulatory effects on the intestinal flora, although conflicting results exist. Fecal microbiota transplantation (FMT) as a treatment for the second or subsequent CDI recurrences has demonstrated a good safety and efficacy in cirrhosis and CDI. Future validation in more prospective studies is needed. Screening of asymptomatic patients appears to be discouraged for the prevention currently, with strict hand hygiene and cleaning of the ward and medical equipment surfaces being the cornerstone of minimizing transmission.
艰难梭菌是一种革兰氏阳性杆菌,经粪口传播,是目前世界范围内最常见的医院感染之一,2016年更名为艰难梭菌。艰难梭菌感染(CDI)是肝硬化中常见的感染,对预后有不良影响。本研究旨在提供具有临床实践意义的简明综述。肝硬化患者CDI患病率上升,而相关死亡率下降。多组危险因素增加肝硬化患者发生CDI的可能性,如抗生素使用、肝硬化严重程度、一些合并症和人口统计学方面。目前在最新的指南中描述了一般人群的治疗。在肝硬化患者中,由于利福昔明和乳果糖对肠道菌群的调节作用,已被证明可降低CDI风险,尽管存在相互矛盾的结果。粪便微生物群移植(FMT)作为第二次或随后CDI复发的治疗已证明在肝硬化和CDI中具有良好的安全性和有效性。需要在更多的前瞻性研究中进一步验证。目前似乎不鼓励对无症状患者进行筛查,严格的手部卫生和病房和医疗设备表面的清洁是最大限度地减少传播的基石。
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引用次数: 7
Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study. 埃塞俄比亚幽门螺杆菌感染的诊断挑战:一项基于社区的横断面研究。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2022-06-02 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4013020
Esayas Kebede Gudina, Hiwot Amare, Solomon Ali, Melkamu Berhane Arefayine, Dagmawi Tewolde, Million Tesfaye Eshete, Mulusew Gerbaba Jebena, Andreas Wieser, Guenter Froeschl, Markos Tesfaye, Hailemichael Desalegn, Mulatu Gashaw

Background: In resource-constrained countries, accurate diagnosis of Helicobacter pylori infection remains a challenge. This study aimed to assess the clinical utility of locally available serological and stool antigen test kits in the management of people with suspected H. pylori infection in Ethiopia.

Methods: A community-based cross-sectional study was conducted with apparently healthy adults and children living in southwest Ethiopia. Participants were interviewed for dyspepsia symptoms and related clinical conditions. H. pylori infection was examined using commercially available serological and stool antigen tests. The association between H. pylori tests and dyspepsia symptoms was analyzed using logistic regression models.

Results: Out of 1392 participants included in the final analysis, 49.1% and 6.5% tested positive for H. pylori infection with serology and stool antigen test kits, respectively. Participants reporting epigastric symptoms in the past three months (AOR = 1.93, 95% CI = 1.28-2.91) and those with recent dyspepsia treatment (AOR = 1.51, 95% CI = 1.05-2.18) were likely to have positive serology test. However, no association between dyspepsia symptoms and H. pylori stool antigen positivity was observed in our study.

Conclusion: ccurate detection of H. pylori infections using commercially accessible diagnostics remains difficult in Ethiopia. With these methods, it will be hard to ensure adequate diagnosis and early treatment of H. pylori infection, as well as rational antibiotic use.

背景:在资源受限的国家,幽门螺杆菌感染的准确诊断仍然是一个挑战。本研究旨在评估埃塞俄比亚当地可用的血清学和粪便抗原检测试剂盒在管理疑似幽门螺杆菌感染患者中的临床应用。方法:以社区为基础的横断面研究对生活在埃塞俄比亚西南部的表面健康的成人和儿童进行了研究。对参与者进行了消化不良症状和相关临床状况的访谈。幽门螺杆菌感染检查使用市售血清学和粪便抗原试验。使用logistic回归模型分析幽门螺杆菌检测与消化不良症状之间的关系。结果:在最终分析的1392名参与者中,血清学和粪便抗原检测试剂盒分别检测出49.1%和6.5%的幽门螺杆菌感染阳性。在过去三个月内报告上腹症状的参与者(AOR = 1.93, 95% CI = 1.28-2.91)和最近接受消化不良治疗的参与者(AOR = 1.51, 95% CI = 1.05-2.18)血清学检测阳性的可能性较大。然而,在我们的研究中没有观察到消化不良症状与幽门螺杆菌粪便抗原阳性之间的联系。结论:在埃塞俄比亚,利用商业上可获得的诊断方法准确检测幽门螺杆菌感染仍然很困难。这些方法将难以保证幽门螺杆菌感染的充分诊断和早期治疗,以及合理使用抗生素。
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引用次数: 2
期刊
Canadian Journal of Gastroenterology and Hepatology
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