Lancet Global Health最新文献

{"title":"Travel bans did not contain omicron: a call for data-driven public health responses.","authors":"Esayas Kebede Gudina, Netsanet Workneh Gidi","doi":"10.1016/S2214-109X(24)00457-1","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00457-1","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e179-e180"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Glob Health 2024; published online Dec 5. https://doi.org/10.1016/S2214-109X(24)00525-4.","authors":"","doi":"10.1016/S2214-109X(24)00532-1","DOIUrl":"10.1016/S2214-109X(24)00532-1","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"e202"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The climate crisis and human health: identifying grand challenges through participatory research.","authors":"J Johanna Sanchez, Evelyn Gitau, Reda Sadki, Charlotte Mbuh, Karlee Silver","doi":"10.1016/S2214-109X(25)00003-8","DOIUrl":"10.1016/S2214-109X(25)00003-8","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":" ","pages":"e199-e200"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the power of multicountry networks for influenza vaccine monitoring.","authors":"Cecile Viboud, Kathleen M Neuzil","doi":"10.1016/S2214-109X(24)00524-2","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00524-2","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e173-e174"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The era of no review: an appraisal on transparency in global health funding.","authors":"Christine Ngaruiya, Calvin Omolo","doi":"10.1016/S2214-109X(24)00485-6","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00485-6","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e194-e195"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for epidemiological data on HIV-related CNS infections in low-income and middle-income settings.","authors":"Regan Solomons, Helena Rabie","doi":"10.1016/S2214-109X(24)00523-0","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00523-0","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e189-e190"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of immunogenicity at 5 years after a single dose of human papillomavirus vaccine compared with two doses in Tanzanian girls aged 9-14 years: results of the long-term extension of the DoRIS randomised trial.","authors":"Deborah Watson-Jones, John Changalucha, Caroline Maxwell, Hilary Whitworth, Paul Mutani, Troy J Kemp, Beatrice Kamala, Jackton Indangasi, George Constantine, Ramadhan Hashim, David Mwanzalima, Rebecca Wiggins, Devis Mmbando, Nicholas Connor, Miquel A Pavon, Brett Lowe, Saidi Kapiga, Philippe Mayaud, Silvia de Sanjosé, Joakim Dillner, Richard J Hayes, Charles J Lacey, Ligia Pinto, Kathy Baisley","doi":"10.1016/S2214-109X(24)00477-7","DOIUrl":"10.1016/S2214-109X(24)00477-7","url":null,"abstract":"<p><strong>Background: </strong>WHO has recommended that one dose of human papillomavirus (HPV) vaccine can be given to individuals aged 9-20 years to prevent HPV infection. Estimating durability of immune responses after a single dose in the target age for vaccination is important. We report immunogenicity results in Tanzanian girls up to 5 years after receiving a dose.</p><p><strong>Methods: </strong>In this open-label, randomised controlled trial (the Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls [DoRIS] trial), 930 Tanzanian schoolgirls aged 9-14 years were enrolled and randomly allocated to receive one, two, or three doses of either the two-valent vaccine (Cervarix; GSK, Wavre, Belgium) or nine-valent vaccine (Gardasil-9; Merck Sharp & Dohme, Haarlem, Netherlands). Seropositivity specific to HPV16 or HPV18, antibody geometric mean concentrations (GMCs), and antibody avidity were measured annually up to month 36. Participants in the one-dose and two-dose groups were followed annually in a long-term extension of the DoRIS trial to month 60; the primary outcome was seropositivity specific to HPV16 or HPV18 comparing one dose with two doses.</p><p><strong>Findings: </strong>Single-dose seropositivity for HPV16 IgG antibodies at month 60 with either vaccine was more than 99% and non-inferior to two doses. 98% of girls in the one-dose two-valent vaccine group and 93% in the one-dose nine-valent group were seropositive for HPV18 at month 60; however, the non-inferiority criteria for HPV18 seropositivity comparing one dose with two doses were not met. Although HPV16 and HPV18 antibody GMCs after one dose were lower than those observed after two doses, antibody GMCs in the one-dose groups remained stable from month 12 to month 60. There was no evidence of a difference between the one-dose and two-dose groups in HPV16 or HPV18 antibody avidity at month 36 for either vaccine.</p><p><strong>Interpretation: </strong>A single dose of HPV vaccine in girls aged 9-14 years continues to provide stable immune responses 5 years after vaccination, although ongoing surveillance for potential waning immunity after a single dose is needed. Participants are being followed up to 9 years after vaccination.</p><p><strong>Funding: </strong>UK Department of Health and Social Care, UK Foreign, Commonwealth & Development Office, Global Challenges Research Fund, UK Medical Research Council, and the Wellcome Trust through the Joint Global Health Trials Scheme; Bill & Melinda Gates Foundation.</p>","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e319-e328"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated oxygen control for preterm infants receiving continuous positive airway pressure in southwest Nigeria: an open-label, randomised, crossover trial.","authors":"Rami Subhi, Lachlann McLeod, Adejumoke Idowu Ayede, Iyabode Olabisi Dedeke, Quadri Risikat, Alao Ridwan Akanbi, Adeola Baliqis Fasasi, Ayobami A Bakare, Oluwatosin Helen Adeniyi, Olugbenga Akinrinoye, Olanrewaju Adeigbe, George F Dargaville, Patrick Walker, Anneke C Grobler, Olufunke Mosebolatan, Shiraz Badurdeen, Timothy J Gale, Adegoke G Falade, Peter A Dargaville, Hamish R Graham","doi":"10.1016/S2214-109X(24)00458-3","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00458-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Titration of oxygen therapy to target safe oxygen saturation (SpO&lt;sub&gt;2&lt;/sub&gt;) values is a vital part of care for preterm infants, but is difficult to achieve, particularly in settings in which oxygen, monitoring technology, and human resources are scarce. We aimed to evaluate the safety and efficacy of automated titration of oxygen therapy partnered with a low-cost continuous positive airway pressure (CPAP) device versus manual oxygen control in preterm infants requiring CPAP in a high-mortality, low-resource setting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this open-label, randomised, crossover trial, preterm infants with a gestational age younger than 34 weeks (or a birthweight &lt;2 kg if gestation was unknown) who were aged 12 h or older and required CPAP and oxygen were recruited at two hospitals in southwest Nigeria. Participants were randomly assigned (1:1) to one of two intervention sequences (ie, to commence the study on automated oxygen control or manual oxygen control) with block randomisation (blocks of 4 and 6) and stratification by health facility. The study statistician was masked to treatment group assignment, but the participants' parents or caregivers and clinical staff were not. Participants received automated or manual oxygen control for two 24-h periods in random sequence. Automated oxygen titration was done with a control algorithm with proven efficacy in high-resource settings. During periods of manual control, oxygen therapy was adjusted by clinicians. The primary outcome was the adjusted mean difference in the proportion of time participants spent in the SpO&lt;sub&gt;2&lt;/sub&gt; target range (ie, SpO&lt;sub&gt;2&lt;/sub&gt; 91-95% when receiving oxygen or SpO&lt;sub&gt;2&lt;/sub&gt; 91-100% when not receiving oxygen) between automated and manual oxygen control, analysed by intention to treat with weighted repeated measures mixed model linear regression. This trial is registered with ClinicalTrials.gov, NCT05508308, and is completed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Findings: &lt;/strong&gt;Between Sept 13, 2022, and Sept 11, 2023, 72 infants were screened, and 49 (22 female, 27 male; median gestation 29 weeks [IQR 28-31]; median birthweight 1·2 kg [1·1-1·5]) were enrolled in the study and randomly assigned. A total of 80 study periods for 46 infants contributed data to the analysis of the primary outcome as three (6%) of the 49 participants had no oxygenation data from either study period. The mean proportion of time spent in the SpO&lt;sub&gt;2&lt;/sub&gt; target range was higher during automated control periods than during periods of manual control (adjusted mean 88·1% [95% CI 84·0-92·2] vs 30·1% [20·9-39·3]; adjusted mean difference 58·0% [95% CI 48·0-67·9]; p&lt;0·0001). There were no device-related adverse patient outcomes and short-term safety outcomes favoured automated control.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Interpretation: &lt;/strong&gt;Automated titration of oxygen partnered with a low-cost CPAP device improved time spent in the safe SpO&lt;sub&gt;2&lt;/sub&gt; range compared with manual cont","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e246-e255"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care for children with critical illness: a global public health need.","authors":"Mohammod Jobayer Chisti, Trevor Duke","doi":"10.1016/S2214-109X(24)00504-7","DOIUrl":"https://doi.org/10.1016/S2214-109X(24)00504-7","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e175-e176"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and NTDs: a perfect storm.","authors":"The Lancet Global Health","doi":"10.1016/S2214-109X(25)00014-2","DOIUrl":"https://doi.org/10.1016/S2214-109X(25)00014-2","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 2","pages":"e172"},"PeriodicalIF":19.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}