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Early assessment of maternal bleeding: development and validation of a prognostic model predicting death and near miss 产妇出血的早期评估:预测死亡和差点漏诊的预后模型的开发和验证
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00488-7
Francois-Xavier Ageron PhD, Katharine Ker PhD, Danielle Prowse MSc, Prof Ewout W Steyerberg PhD, Eni Balogun MSc, Prof Haleema Shakur-Still MSc, Prof Folasade Adenike Bello PhD, Hugo Madar PhD, Catherine Deneux-Tharaux PhD, Prof Rizwana Chaudhri FRCOG, Prof Oladapo Olayemi FWACS, Prof Projestine Muganyizi PhD, Prof Loïc Sentilhes PhD, Prof Ian Roberts PhD, Anti-fibrinolytics Trialists Collaborators Obstetric Group, Francois-Xavier Ageron, Homa Ahmadzia, Monica Arribas, Eni Balogun, Amy Brenner, Rizwana Chaudhri, Catherine Deneux-Tharaux, Amber Geer, Katharine Ker, Hugo Madar, Raoul Mansukhani, Oladapo Olayemi, Luis D Pacheco, Danielle Prowse, George Saade, Ian Roberts, Haleema Shakur-Still, Loïc Sentilhes
Bleeding after childbirth is a leading cause of mortality. Most deaths are in low-income and middle-income countries. Early identification of women at high risk of life-threatening bleeding is vital to guide the use of life-saving interventions. The aim of this study was to develop and validate a prognostic model to predict death and near miss from bleeding after childbirth and to use it to a create simple clinical score to identify women's level of risk at admission.
分娩后出血是导致死亡的主要原因。大多数死亡发生在低收入和中等收入国家。早期发现危及生命的出血高危妇女对于指导使用挽救生命的干预措施至关重要。本研究的目的是开发和验证一个预后模型,以预测分娩后出血导致的死亡和差点漏诊,并使用它来创建一个简单的临床评分,以确定妇女入院时的风险水平。
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引用次数: 0
Gaps in government recognition of the service needs of women who experience intimate partner violence: a comparative case study analysis of policies and implementation across eight countries 政府在承认遭受亲密伴侣暴力的妇女的服务需求方面的差距:对八个国家政策和执行情况的比较案例研究分析
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00487-5
Prof Merike Blofield PhD, Kristen Danforth PhD, Shanaaz Matthews PhD, Diana Acuña LLM, Benedetta Armocida PhD, Paula Dias Bevilacqua PhD, Aislinn Delany MA, Padma Bhate-Deosthali PhD, Beatrice Formenti BA, María Ana González MSc, Nancy Madera BA, Deborah Malta PhD, Dianah Kagere Mugerwa MA, Johanna Pieper MA, Isabella Vitral Pinto PhD, Claudia Garcia Moreno MD, Mary Ellsberg PhD, Flavia Bustreo MD, Felicia Knaul PhD
Intimate partner violence (IPV) is a substantial health and human rights concern. Governmental policies to address IPV are well-documented, but most available evidence on implementation focuses on specific initiatives covering small groups, and little is known about IPV policy responses at a national level. We conducted a comparative case study analysis on eight countries (Brazil, Chile, Colombia, India, Italy, South Africa, Spain, and Uganda) between January, 2024, and May, 2025. Drawing on police, health, and social sector administrative data, we assessed the extent to which governments recognise and respond to the need for services by women who have experienced IPV. We found varying levels of government response across countries. A qualitative analysis of the recognition gap—including access to care pathways and intersectoral coordination—identified ways to improve responses, including leveraging health sectors. The analysis moves us beyond counts of policy adoption and provides a novel approach in assessing responsiveness of services for women experiencing violence.
亲密伴侣暴力是一个重大的健康和人权问题。政府解决IPV问题的政策有据可查,但大多数关于执行的现有证据侧重于针对小团体的具体举措,对国家一级的IPV政策反应知之甚少。我们在2024年1月至2025年5月期间对8个国家(巴西、智利、哥伦比亚、印度、意大利、南非、西班牙和乌干达)进行了比较案例研究分析。根据警察、卫生和社会部门的行政数据,我们评估了各国政府在多大程度上认识到并响应经历过IPV的妇女对服务的需求。我们发现各国政府的反应程度各不相同。对认识差距(包括获得保健途径和部门间协调)的定性分析确定了改进应对措施的方法,包括利用卫生部门。该分析使我们超越了政策采用的数量,并提供了一种新的方法来评估为遭受暴力的妇女提供服务的反应能力。
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引用次数: 0
Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy 低剂量阿司匹林预防镰状细胞妊娠宫内生长受限和先兆子痫
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00482-6
Lydia H Pecker, Sophie M Lanzkron
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引用次数: 0
Thank you to The Lancet Global Health's statistical and peer reviewers in 2025 感谢《柳叶刀全球健康》2025年的统计和同行审稿人
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(26)00012-4
Zoë Mullan
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引用次数: 0
Beyond disclosure: stop using AI imagery in global health 除披露外:停止在全球卫生领域使用人工智能图像
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00492-9
Imogen Bakelmun, Kent Buse
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引用次数: 0
Effectiveness of behavioural tobacco cessation interventions with and without pharmacotherapy among people living with HIV in Viet Nam: a three-arm pragmatic randomised controlled trial 越南艾滋病毒感染者中有和没有药物治疗的行为戒烟干预措施的有效性:一项三组实用随机对照试验
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00451-6
Prof Donna Shelley MD, Mari Armstrong-Hough PhD, Trang Nguyen MA, Gloria Guevara Alvarez PhD, Reet Kapur MPH, Prof Jonathan Shuter MD, Lloyd Goldsamt PhD, Yesim Tozan PhD, Prof Hoang Van Minh PhD, Giap Van Vu PhD, Phuong Thu Phan MD, Charles M Cleland PhD, Nam Nguyen DrPH
People living with HIV are two to three times more likely to smoke than the general population, resulting in higher risk for tobacco-related morbidity and mortality. Despite this growing burden of disease, there is little evidence for the long-term effectiveness of tobacco cessation interventions among people living with HIV, particularly in low-income and middle-income countries. We aimed to compare the effectiveness of three tobacco cessation interventions among people living with HIV.
艾滋病毒感染者吸烟的可能性是一般人群的两到三倍,导致与烟草有关的发病率和死亡率的风险更高。尽管这种疾病负担日益加重,但几乎没有证据表明,戒烟干预措施在艾滋病毒感染者中,特别是在低收入和中等收入国家,具有长期效力。我们的目的是比较三种戒烟干预措施在艾滋病毒感染者中的有效性。
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引用次数: 0
Rethinking practice guidelines for supporting LGBTQIA+ health service use 重新思考支持LGBTQIA+使用卫生服务的实践指南
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00519-4
Shao Yuan Chong, Norman Chong, Lain Shae Goh, Daniel Weng Siong Ho, Hau-Chi Hsu, Jessica Liao, Ashley Hui Ying Teh, Ye Xuan Wee, Valerie Cheng Yee Eng, Rayner Kay Jin Tan
{"title":"Rethinking practice guidelines for supporting LGBTQIA+ health service use","authors":"Shao Yuan Chong, Norman Chong, Lain Shae Goh, Daniel Weng Siong Ho, Hau-Chi Hsu, Jessica Liao, Ashley Hui Ying Teh, Ye Xuan Wee, Valerie Cheng Yee Eng, Rayner Kay Jin Tan","doi":"10.1016/s2214-109x(25)00519-4","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00519-4","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"15 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avoidable deaths through the primary prevention, early detection, and curative treatment of cancer worldwide: a population-based study 通过全球一级预防、早期发现和治愈性治疗癌症可避免的死亡:一项基于人群的研究
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00494-2
Oliver Langselius PhD, Harriet Rumgay PhD, Jérôme Vignat MSc, Hadrien Charvat PhD, Mark J Rutherford PhD, Allini Mafra PhD, Eileen Morgan PhD, Mengmeng Li PhD, Luz M Sánchez-Romero PhD, Kate Simms PhD, Freddie Bray PhD, Isabelle Soerjomataram PhD
Global disparities exist in cancer incidence, mortality, and survival. We aimed to provide estimates of avoidable deaths among people diagnosed with cancer to inform the prioritisation of interventions and narrow cancer inequalities.
全球在癌症发病率、死亡率和生存率方面存在差异。我们的目的是提供癌症患者可避免死亡的估计,为干预措施的优先次序和缩小癌症不平等提供信息。
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引用次数: 0
Characterising progression and regression patterns across the spectrum of tuberculosis: a multistate modelling approach 描述结核病的进展和回归模式:一种多状态建模方法
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00454-1
Leyla Larsson MSc, Claire J Calderwood PhD, Edson T Marambire PhD, Rishi K Gupta PhD, Denise Banze MD, Alfred Mfinanga MD, Mishelle Mugava BSc, Etienne Leroy-Terquem MD, Prof Joseph Jacob PhD, Daisuke Yamada PhD, Francisco Trinchan Fernandez MD, Patrick Lungu PhD, Anita Mesic PhD, Celso Khosa PhD, Tina Minja MD, Junior Mutsvangwa PhD, Michael Lauseker PhD, Kathrin Held PhD, Norbert Heinrich MD, Prof Katharina Kranzer PhD, ERASE-TB consortium, Norbert Heinrich, Ursula Panzner, Christof Geldmacher, Kathrin Held, Andrea Rachow, Friedrich Riess, Tejaswi Appalarowthu, Deepika Zende, Anna-Lisa Behnke, Lilian Tina Minja, Nyanda Elias Ntinginya, Issa Sabi, Alfred Mfinanga, Harrieth Mwambola, Lwithio Sudi, Bariki Mtafya, Emanuel Sichone, Doreen Pamba, Abisai Kisinda, Peter Towo, Lilian Njovu, Alice Shoo, Willyhelmina Olomi, Celso Khosa, Denise Floripes Banze, Nelson Tembe, Nadia Sitoe, Carla Madeira, Candido Azize, Celina Nhamuave, Sidonia Nhacubangane, Jorge Ribeiro, Junior Mutsvangwa, Edson Marambire, Fungai Kavenga, Tsitsi Bandason, Kuda Mutasa, Martha Chipinduro, Sandra Rukobo, Mishelle Mugava, Beauty Makamure, Forget Makoga, Katharina Kranzer, Claire Calderwood, Hazel Dockrell, Leyla Larsson, Anna Shepherd, Gunilla Källenius, Christopher Sundling, Lindsay Zurba
The conceptualisation of tuberculosis has undergone a paradigm shift from binary states to a spectrum, resulting in the International Consensus for Early TB (ICE-TB) framework. This study aimed to use data from a prospective, observational cohort study and multistate modelling to address the lack of contemporary data to quantify movement between ICE-TB states.
结核病的概念化经历了从二元状态到频谱的范式转变,从而产生了早期结核病国际共识框架。本研究旨在利用前瞻性、观察性队列研究和多状态模型的数据来解决缺乏当代数据来量化ICE-TB状态之间的运动。
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引用次数: 0
Measuring the impact of global research and development investment in product development partnerships: a case study on return on investment in antimalarial drug development 衡量全球研发投资对产品开发伙伴关系的影响:抗疟疾药物开发投资回报案例研究
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-16 DOI: 10.1016/s2214-109x(25)00456-5
Paula Christen PhD, Céline Audibert PhD, Jo-Ann Mulligan PhD, Oliver Bubb-Humfryes MA, Christian von Drehle MSc, Lesong Conteh PhD
Product development partnerships (PDPs) are non-profit organisations that bridge the gap between the need for new treatments for poverty-related diseases and the resources available to develop them, leveraging a mix of public, philanthropic, multilateral, and private sector funding. We aimed to calculate two financial metrics to estimate the return on investments of drugs developed by the PDP Medicines for Malaria Venture (MMV) as a case study.
产品开发伙伴关系(pdp)是非营利组织,它利用公共、慈善、多边和私营部门的资金,弥合了对与贫困有关的疾病的新治疗方法的需求与开发这些方法的可用资源之间的差距。我们的目的是计算两个财务指标,以估计PDP疟疾药物风险(MMV)开发的药物的投资回报,作为一个案例研究。
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Lancet Global Health
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