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Influence of different forms of folic acid supplementation on pregnancy outcomes under various exposure factors. 在不同暴露因素下,不同形式的叶酸补充剂对妊娠结局的影响。
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-241034
Jie Song,Ruihong Lan,Dahua Yin,Ling Wang,Humin Gong
BACKGROUNDFolic acid supplementation has been shown to provide benefits in preventing neural tube defects and other birth defects, as well as reducing adverse pregnancy outcomes.OBJECTIVEThis study aimed to examine the impact of various folic acid supplementation methods on pregnancy.METHODSTaqMan-MGB technology was used to detect polymorphisms in the folate metabolism-related genes, MTHFR C677T and A1298C. Blood-related biochemical indicators, including HCY levels and history of adverse pregnancy, were examined in relation to different exposure factors (MTHFR gene polymorphism, HCY levels, and adverse pregnancy history) and their impact on pregnancy outcomes. Various forms of folic acid intervention were implemented in a population with an adverse pregnancy history and high HCY levels to analyze the effects of reducing HCY levels and improving pregnancy outcomes.RESULTSExposure factors, such as adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were closely associated with pregnancy outcomes. Interestingly, methylfolate efficiently reduced the serum HCY levels. More importantly, the methylfolate group exhibited a significantly lower incidence of adverse pregnancies than the synthetic folic acid group.CONCLUSIONIn this study, the risk factors, including adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were confirmed to lead to the poorer pregnancy outcomes in our cohort. 5-methyltetrahydrofolate may be an effective approach for decreasing the incidence of adverse pregnancy outcomes.
背景补充叶酸已被证明对预防神经管畸形和其他出生缺陷以及减少不良妊娠结局有益处。血液相关生化指标(包括 HCY 水平和不良妊娠史)与不同暴露因素(MTHFR 基因多态性、HCY 水平和不良妊娠史)的关系及其对妊娠结局的影响进行了研究。结果不良妊娠史、HCY 和中高风险基因代谢等暴露因素与妊娠结局密切相关。有趣的是,甲叶酸能有效降低血清中的 HCY 水平。更重要的是,与合成叶酸组相比,甲叶酸组的不良妊娠发生率明显较低。5-甲基四氢叶酸可能是降低不良妊娠结局发生率的有效方法。
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引用次数: 0
An automated ECG-based deep learning for the early-stage identification and classification of cardiovascular disease. 基于心电图的自动深度学习,用于心血管疾病的早期识别和分类。
IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/THC-240543
Anand Pandey, Ajeet Singh, Prasanthi Boyapati, Abhay Chaturvedi, N Purushotham, Sangeetha M

Background: Heart disease represents the leading cause of death globally. Timely diagnosis and treatment can prevent cardiovascular issues. An Electrocardiograms (ECG) serves as a diagnostic tool for identifying heart difficulties. Cardiovascular Disease (CVD) often gets identified through ECGs. Deep learning (DL) garners attention in healthcare due to its potential in swiftly diagnosing ECG anomalies, crucial for patient monitoring. Conversely, automatic CVD detection from ECGs poses a challenging task, wherein rule-based diagnostic models usually achieve top-notch performance. These models encounter complications in supervision vast volumes of diverse data, demanding widespread analysis and medical capability to ensure precise CVD diagnosis.

Objective: This study aims to enhance cardiovascular disease diagnosis by combining symptom-based detection and ECG analysis.

Methods: To enhance these experiments, we built a novel automated prediction method based on a Feed Forward Neural Network (FFNN) model. The fundamental objective of our method is to develop the accuracy of ECG diagnosis. Our strategy employs chaos theory and destruction analysis to combine optimum deep learning features with a well-organized set of ECG properties. In addition, we use the constant-Q non-stationary Gabor transform (CQNGT) to convert one-dimensional ECG data into a two-dimensional picture. A pre-trained FFNN processes this image. To identify significant features from the FFNN output that correspond with the ECG data, we employ pairwise feature proximity.

Results: According to experimental findings, the suggested system, FFNN-CQNGT, surpasses other state-of-the-art systems in terms of precision of 94.89%, computational efficiency of 2.114 ms, accuracy of 95.55%, specificity of 93.77%, and sensitivity of 93.99% and MSE 40.32%.

Conclusion: Contributing an automated ECG-based DL system based on FFNN-CQNGT for early-stage cardiovascular disease identification and classification holds great potential for both patient care and public health.

背景:心脏病是导致全球死亡的主要原因。及时诊断和治疗可以预防心血管问题。心电图(ECG)是识别心脏疾病的诊断工具。心血管疾病(CVD)通常通过心电图来识别。深度学习(DL)因其在快速诊断心电图异常方面的潜力而在医疗保健领域备受关注,这对患者监测至关重要。相反,从心电图中自动检测心血管疾病是一项极具挑战性的任务,而基于规则的诊断模型通常能实现一流的性能。这些模型在监管大量不同数据时会遇到复杂问题,需要广泛的分析和医疗能力来确保对心血管疾病的精确诊断:本研究旨在通过将基于症状的检测与心电图分析相结合,提高心血管疾病诊断水平:为了加强这些实验,我们建立了一种基于前馈神经网络(FFNN)模型的新型自动预测方法。我们方法的基本目标是提高心电图诊断的准确性。我们的策略采用混沌理论和破坏分析法,将最佳深度学习特征与组织良好的心电图属性集相结合。此外,我们还使用恒Q非稳态Gabor变换(CQNGT)将一维心电图数据转换为二维图像。预先训练好的 FFNN 处理该图像。为了从 FFNN 输出中识别出与心电图数据相对应的重要特征,我们采用了成对特征接近法:根据实验结果,建议的 FFNN-CQNGT 系统在精确度 94.89%、计算效率 2.114 毫秒、准确度 95.55%、特异性 93.77%、灵敏度 93.99% 和 MSE 40.32% 等方面超越了其他最先进的系统:基于 FFNN-CQNGT 的自动心电图 DL 系统可用于早期心血管疾病的识别和分类,在患者护理和公共卫生方面具有巨大潜力。
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引用次数: 0
A Bayesian network analysis of the probabilistic relationships between metabolically healthy obesity and cardiovascular disease risk under new diagnostic criteria. 新诊断标准下代谢健康肥胖与心血管疾病风险之间概率关系的贝叶斯网络分析。
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-241472
Shuo Chen,Peixian Wu,Weiqun Peng,Hongai Zhang
BACKGROUNDThe relationship between metabolically healthy obesity (MHO) and cardiovascular disease (CVD) risk remains debated. The critical point may be the lack of consensus on MHO's definition and diagnostic criteria.OBJECTIVEThis study aimed to investigate the association of MHO status with arteriosclerosis-CVD (ASCVD) risk in Chinese under new diagnostic criteria.METHODSParticipants aged 35-79 in the 2009 China Health and Nutrition Survey cohort were included. The 10-year ASCVD risk was predicted by the prediction for ASCVD risk in China, and participants with a predicted risk of ⩾ 10% were classified into the high-risk group. The Bayesian network (BN) models were constructed to characterize the multivariable probabilistic connections between metabolically obesity phenotypes and ASCVD risk.RESULTSThe 10-year ASCVD risk score and the proportion of individuals at ASCVD high risk were significantly different between metabolically obesity phenotypes (P< 0.001). BN reasoning results showed that MHO individuals were not significantly associated with a 10-year ASCVD risk. Among metabolically unhealthy individuals, the conditional probability of high ASCVD risk increased with the Body Mass Index (BMI), with the conditional probability of high ASCVD risk was 24.63% (95% CI: 22.81-26.55%), 32.97% (95% CI: 30.75-35.27%) and 40.2% (95% CI: 36.64-43.86%) for metabolically unhealthy normal weight (MUNW), metabolically healthy overweight weight (MHOW), and metabolically unhealthy obesity (MUO) group, respectively. Subgroup analysis showed that MHO individuals were at increased risk of CVD compared with metabolically healthy normal weight (MHNW) individuals only in females.CONCLUSIONThese results showed that there was no significant increase in ASCVD risk of MHO phenotype based on the new diagnostic criteria, suggesting that MHO is in a relatively healthy state.
背景代谢性健康肥胖(MHO)与心血管疾病(CVD)风险之间的关系仍存在争议。本研究旨在根据新的诊断标准调查中国人的 MHO 状态与动脉硬化-心血管疾病(ASCVD)风险的关系。根据中国 ASCVD 风险预测法预测 10 年 ASCVD 风险,将预测风险⩾10% 的参与者归入高风险组。结果不同代谢肥胖表型之间的10年ASCVD风险评分和ASCVD高危人群比例存在显著差异(P< 0.001)。BN推理结果显示,MHO个体与10年ASCVD风险无明显关联。在代谢不健康个体中,ASCVD 高风险的条件概率随身体质量指数(BMI)的增加而增加,ASCVD 高风险的条件概率分别为 24.63% (95% CI:22.81-26.55%)、32.代谢不健康正常体重(MUNW)组、代谢健康超重体重(MHOW)组和代谢不健康肥胖(MUO)组的条件概率分别为 24.63% (95% CI: 22.81-26.55%)、32.97% (95% CI: 30.75-35.27%) 和 40.2% (95% CI: 36.64-43.86%)。亚组分析表明,与代谢健康的正常体重(MHNW)人群相比,MHO人群的心血管疾病风险仅在女性中有所增加。
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引用次数: 0
Nd: YAG laser irradiation in the treatment of live pulp preservation in pediatric cariogenic pulpitis. 掺钕钇钕石榴石(Nd: YAG)激光照射治疗小儿龋源性牙髓炎的活髓保存。
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-241233
Mengxing Wang,Tian Xia,Ying Wang
BACKGROUNDDental pulpitis significantly impacts oral function and quality of life. Treatments like direct pulp capping aim to preserve pulp vitality.OBJECTIVEThis study aims to investigate the application value of Nd:YAG laser irradiation in preserving pulp vitality in children with caries-induced pulpitis.METHODSThis study, conducted from June 2019 to June 2023, included 89 children undergoing pulp vitality preservation treatment for caries-induced pulpitis. The children were divided into two groups using sealed envelopes: 44 in the control group received pulp capping treatment, while the study group received Nd:YAG laser-assisted pulp capping treatment. The efficacy, oral indicators, oral function, changes in root apex diameter and root length, changes in gingival crevicular fluid inflammatory factors, and incidence of complications were compared between the two groups before and 3 months after treatment.RESULTSThe total effective rates were 97.78% in the study group and 95.45% in the control group, with no significant difference between the groups (p> 0.05). Before treatment, there were no differences in gingival index, plaque index, and probing bleeding index between the groups (p> 0.05). After treatment, both groups showed decreased periodontal indexes compared to before treatment, with the study group showing lower values than the control group (p< 0.05). Chewing and biting function scores were similar between the groups before and after treatment (p> 0.05), but both groups showed decreased scores after treatment (p< 0.05). The study group had a higher percentage decrease in root apex diameter and a greater increase in root length compared to the control group (p< 0.05). During treatment, one case of tooth discoloration occurred in the study group (2.27%), while the control group had two cases of tooth discoloration and one case of secondary caries, resulting in a complication rate of 6.67%. There was no significant difference in the incidence of complications between the groups (p> 0.05).CONCLUSIONNd:YAG laser irradiation effectively preserves pulp vitality in children with caries-induced pulpitis, improving periodontal health, reducing root apex diameter, and increasing root length with high safety.
背景牙髓炎严重影响口腔功能和生活质量。本研究旨在探讨 Nd:YAG 激光照射在龋诱发牙髓炎儿童牙髓活力保存治疗中的应用价值。方法本研究于 2019 年 6 月至 2023 年 6 月进行,共纳入 89 名因龋诱发牙髓炎接受牙髓活力保存治疗的儿童。使用密封信封将儿童分为两组:对照组 44 名儿童接受牙髓封闭治疗,研究组接受 Nd:YAG 激光辅助牙髓封闭治疗。结果研究组总有效率为97.78%,对照组总有效率为95.45%,组间差异无显著性(P>0.05)。治疗前,两组的牙龈指数、牙菌斑指数和探诊出血指数无差异(P> 0.05)。治疗后,与治疗前相比,两组的牙周指数均有所下降,研究组的数值低于对照组(P< 0.05)。两组在治疗前后的咀嚼和咬合功能评分相似(P> 0.05),但两组在治疗后的评分均有所下降(P< 0.05)。与对照组相比,研究组的牙根顶直径减少的百分比更高,而牙根长度增加的百分比更大(P< 0.05)。在治疗过程中,研究组有一例牙齿变色(2.27%),而对照组有两例牙齿变色和一例继发性龋齿,并发症发生率为 6.67%。结论掺钕钇钕石榴石(YAG)激光照射可有效保护龋齿诱发牙髓炎患儿的牙髓活力,改善牙周健康,缩小根尖直径,增加根长,安全性高。
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引用次数: 0
Clinical efficacy of tension-free vaginal tape-ischiopubic ramus versus transobturator tension-free vaginal tape in the management of female stress urinary incontinence. 在治疗女性压力性尿失禁方面,无张力阴道胶带-髂耻骨横突与经尿道无张力阴道胶带的临床疗效对比。
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-241247
Yingqing Ruan,Ping Liu,Minjie Qiu
BACKGROUNDStress urinary incontinence (SUI), a prevalent condition among middle-aged and elderly women in China, is characterized by the involuntary leakage of urine during instances of increased abdominal pressure [1]. Although SUI is not life-threatening, it substantially impacts patients' physical and psychological well-being, impairs their social interactions, and diminishes their overall quality of life.OBJECTIVEThe aim of this study was to evaluate and compare the clinical efficacy of tension-free vaginal tape-ischiopubic ramus (TVT-IR) and transobturator tension-free vaginal tape (TVT-O) in the treatment of female stress urinary incontinence (SUI).METHODSA retrospective analysis of clinical data from 83 female SUI patients was conducted, dividing them into a TVT-IR group (n= 41) and a TVT-O group (n= 42) based on the surgical procedures employed. Perioperative indices, surgical efficacy, complications, symptom improvement pre- and post-operation (3 months), urodynamic measurements, and indices related to pelvic floor function and quality of life were compared between the two groups.RESULTSThe TVT-IR group had significantly shorter operative time than the TVT-O group (P< 0.05). Three months after surgery, both groups had significantly lower frequency of incontinence, incontinence score, and number of nocturnal urination, significantly higher Pdet, ALPP, Qmax, and MUCP, significantly higher class I and class II fiber muscle strength and muscle potential, and significantly higher I-QOL scores (P< 0.05). The aforementioned indicators were superior in the TVT-IR group compared to the TVT-O group three months after surgery (P< 0.05).CONCLUSIONBoth TVT-IR and TVT-O are effective in treating SUI, with comparable complication rates.
背景压力性尿失禁(SUI)是中国中老年妇女的一种常见病,其特点是在腹压增加时不自主地漏尿[1]。本研究旨在评估和比较无张力阴道粘贴带-髂耻骨横突(TVT-IR)和经尿道无张力阴道粘贴带(TVT-O)治疗女性压力性尿失禁(SUI)的临床疗效。方法对 83 名女性 SUI 患者的临床数据进行回顾性分析,根据采用的手术方法将其分为 TVT-IR 组(41 人)和 TVT-O 组(42 人)。比较了两组患者的围手术期指标、手术疗效、并发症、手术前后(3 个月)症状改善情况、尿动力学测量结果以及盆底功能和生活质量相关指标。术后三个月,两组患者的尿失禁频率、尿失禁评分和夜尿次数均明显降低,Pdet、ALPP、Qmax和MUCP均明显提高,I级和II级纤维肌力和肌电位明显提高,I-QOL评分明显提高(P< 0.05)。术后三个月,TVT-IR 组的上述指标均优于 TVT-O 组(P< 0.05)。
{"title":"Clinical efficacy of tension-free vaginal tape-ischiopubic ramus versus transobturator tension-free vaginal tape in the management of female stress urinary incontinence.","authors":"Yingqing Ruan,Ping Liu,Minjie Qiu","doi":"10.3233/thc-241247","DOIUrl":"https://doi.org/10.3233/thc-241247","url":null,"abstract":"BACKGROUNDStress urinary incontinence (SUI), a prevalent condition among middle-aged and elderly women in China, is characterized by the involuntary leakage of urine during instances of increased abdominal pressure [1]. Although SUI is not life-threatening, it substantially impacts patients' physical and psychological well-being, impairs their social interactions, and diminishes their overall quality of life.OBJECTIVEThe aim of this study was to evaluate and compare the clinical efficacy of tension-free vaginal tape-ischiopubic ramus (TVT-IR) and transobturator tension-free vaginal tape (TVT-O) in the treatment of female stress urinary incontinence (SUI).METHODSA retrospective analysis of clinical data from 83 female SUI patients was conducted, dividing them into a TVT-IR group (n= 41) and a TVT-O group (n= 42) based on the surgical procedures employed. Perioperative indices, surgical efficacy, complications, symptom improvement pre- and post-operation (3 months), urodynamic measurements, and indices related to pelvic floor function and quality of life were compared between the two groups.RESULTSThe TVT-IR group had significantly shorter operative time than the TVT-O group (P< 0.05). Three months after surgery, both groups had significantly lower frequency of incontinence, incontinence score, and number of nocturnal urination, significantly higher Pdet, ALPP, Qmax, and MUCP, significantly higher class I and class II fiber muscle strength and muscle potential, and significantly higher I-QOL scores (P< 0.05). The aforementioned indicators were superior in the TVT-IR group compared to the TVT-O group three months after surgery (P< 0.05).CONCLUSIONBoth TVT-IR and TVT-O are effective in treating SUI, with comparable complication rates.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease. 冠状动脉内心电图在诊断冠心病心肌缺血中的价值和准确性。
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-240837
Shanwen Zhang,Zhimin Bao,Taotao Liao,Zhenying Pei,Shiyu Yang,Chunjiao Zhao,Yuping Zhang
BACKGROUNDAlthough intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.OBJECTIVETo analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.METHODSThree hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] > 0.8) and ischemic group B (FFR < 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR > 0.8) and ischemic subgroup B2 (FFR < 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters.RESULTSGroup A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group (p< 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia (p< 0.05).CONCLUSIONIntracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.
背景虽然与心电图(ECG)等常见诊断方法相比,冠状动脉内心电图(IC-ECG)可直接从电生理角度了解冠状动脉供血不足导致的心肌缺血,但它缺乏广泛的应用和有力的临床研究。根据 FFR 检查结果,将患者分为非缺血 A 组(FFR > 0.8)和缺血 B 组(FFR < 0.75)。两组均接受 IC-ECG 检查。缺血组接受经皮冠状动脉介入(PCI)治疗,然后再次进行 FFR 检查,将其分为非缺血亚组 B1(FFR > 0.8)和缺血亚组 B2(FFR < 0.75)。两个亚组均接受了 IC-ECG 检查。结果 A组患者的J点ST段移位、ST段积分、T峰、T波积分和T峰至终点时间显著下降,而B组患者的校正Q-T间期(QTc-time)显著升高(P< 0.05)。结论冠状动脉心电图 QT 间期弥散和 Q-T 峰(QTp)间期弥散对冠心病心肌缺血有较高的诊断准确性。
{"title":"The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease.","authors":"Shanwen Zhang,Zhimin Bao,Taotao Liao,Zhenying Pei,Shiyu Yang,Chunjiao Zhao,Yuping Zhang","doi":"10.3233/thc-240837","DOIUrl":"https://doi.org/10.3233/thc-240837","url":null,"abstract":"BACKGROUNDAlthough intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.OBJECTIVETo analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.METHODSThree hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] > 0.8) and ischemic group B (FFR < 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR > 0.8) and ischemic subgroup B2 (FFR < 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters.RESULTSGroup A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group (p< 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia (p< 0.05).CONCLUSIONIntracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous glucose monitoring using machine learning models and IoT device data: A meta-analysis. 使用机器学习模型和物联网设备数据进行连续葡萄糖监测:荟萃分析
IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3233/thc-241403
Yagyesh Kapoor,Yasha Hasija
BACKGROUNDMachine learning offers diverse options for effectively managing blood glucose levels in diabetes patients. Selecting the right ML algorithm is critical given the array of available choices. Integrating data from IoT devices presents promising opportunities to enhance real-time blood glucose management models.OBJECTIVEThis meta-analysis aims to evaluate the effectiveness of machine learning models utilizing IoT device data for predicting blood glucose levels.METHODSWe systematically searched electronic databases for studies published between 2019 and 2023. We excluded studies lacking ML model derivation or performance metrics. The Quality Assessment of Diagnostic Accuracy Studies tool assessed study quality. Our primary outcomes compared ML models for BG level prediction across different prediction horizons (PHs).RESULTSWe analyzed ten eligible studies across prediction horizons of 15, 30, 45, and 60 minutes. ML models exhibited mean absolute RMSE values of 15.02 (SD 1.45), 21.488 (SD 2.92), 30.094 (SD 3.245), and 35.89 (SD 6.4) mg/dL, respectively. Random Forest demonstrated superior performance across these PHs.CONCLUSIONWe observed significant heterogeneity across all subgroups, indicating diverse sources of variability. As the PH lengthened, the RMSE for blood glucose prediction by the ML model increased, with Random Forest showing the highest relative performance among the ML models.
背景机器学习为有效管理糖尿病患者的血糖水平提供了多种选择。在众多可用选择中,选择正确的 ML 算法至关重要。整合物联网设备的数据为增强实时血糖管理模型提供了大有可为的机会。目的本荟萃分析旨在评估利用物联网设备数据预测血糖水平的机器学习模型的有效性。方法我们系统地搜索了电子数据库中 2019 年至 2023 年间发表的研究。我们排除了缺乏 ML 模型推导或性能指标的研究。诊断准确性研究质量评估工具对研究质量进行了评估。我们的主要结果比较了不同预测范围(PHs)内预测血糖水平的 ML 模型。结果我们分析了 10 项符合条件的研究,预测范围分别为 15、30、45 和 60 分钟。ML 模型的平均绝对 RMSE 值分别为 15.02 (SD 1.45)、21.488 (SD 2.92)、30.094 (SD 3.245) 和 35.89 (SD 6.4) mg/dL。我们在所有亚组中观察到了显著的异质性,这表明变异性的来源多种多样。随着 PH 的延长,ML 模型预测血糖的均方根误差(RMSE)也在增加,而随机森林在 ML 模型中表现出最高的相对性能。
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引用次数: 0
Enhancing liver tumor segmentation with UNet-ResNet: Leveraging ResNet's power. 利用 UNet-ResNet 增强肝脏肿瘤分割:利用 ResNet 的强大功能
IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-19 DOI: 10.3233/THC-230931
K Selva Sheela, Vivek Justus, Renas Rajab Asaad, R Lakshmana Kumar

Background: Liver cancer poses a significant health challenge due to its high incidence rates and complexities in detection and treatment. Accurate segmentation of liver tumors using medical imaging plays a crucial role in early diagnosis and treatment planning.

Objective: This study proposes a novel approach combining U-Net and ResNet architectures with the Adam optimizer and sigmoid activation function. The method leverages ResNet's deep residual learning to address training issues in deep neural networks. At the same time, U-Net's structure facilitates capturing local and global contextual information essential for precise tumor characterization. The model aims to enhance segmentation accuracy by effectively capturing intricate tumor features and contextual details by integrating these architectures. The Adam optimizer expedites model convergence by dynamically adjusting the learning rate based on gradient statistics during training.

Methods: To validate the effectiveness of the proposed approach, segmentation experiments are conducted on a diverse dataset comprising 130 CT scans of liver cancers. Furthermore, a state-of-the-art fusion strategy is introduced, combining the robust feature learning capabilities of the UNet-ResNet classifier with Snake-based Level Set Segmentation.

Results: Experimental results demonstrate impressive performance metrics, including an accuracy of 0.98 and a minimal loss of 0.10, underscoring the efficacy of the proposed methodology in liver cancer segmentation.

Conclusion: This fusion approach effectively delineates complex and diffuse tumor shapes, significantly reducing errors.

背景:肝癌发病率高,检测和治疗复杂,是一项重大的健康挑战。利用医学成像对肝脏肿瘤进行精确分割在早期诊断和治疗规划中起着至关重要的作用:本研究提出了一种将 U-Net 和 ResNet 架构与 Adam 优化器和 sigmoid 激活函数相结合的新方法。该方法利用 ResNet 的深度残差学习来解决深度神经网络的训练问题。同时,U-Net 的结构有助于捕捉对精确描述肿瘤特征至关重要的局部和全局上下文信息。该模型旨在通过整合这些架构,有效捕捉错综复杂的肿瘤特征和上下文细节,从而提高分割准确性。亚当优化器在训练过程中根据梯度统计动态调整学习率,从而加快模型收敛:为了验证所提方法的有效性,我们在由 130 张肝癌 CT 扫描图像组成的各种数据集上进行了分割实验。此外,还引入了一种最先进的融合策略,将 UNet-ResNet 分类器的强大特征学习能力与基于蛇的水平集分割相结合:实验结果显示了令人印象深刻的性能指标,包括 0.98 的准确率和 0.10 的最小损失,凸显了所提方法在肝癌分割中的功效:结论:这种融合方法能有效地划分复杂和弥漫的肿瘤形状,大大减少误差。
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引用次数: 0
Secure data communication in WSHN using EXP-MD5 and DHSK-ECC. 使用 EXP-MD5 和 DHSK-ECC 在 WSHN 中进行安全数据通信。
IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-08 DOI: 10.3233/THC-240790
Tamarapalli Anjikumar, A S N Chakravarthy
<p><strong>Background: </strong>In the Healthcare (HC) sector, the usage of Wireless Sensor Healthcare Networks (WSHN) is attaining specific importance. The sensor device is implanted into the patient's body, and the sensed health information of patients is transformed via data aggregating devices like mobile devices, cameras, and so on, to the doctors. Thus, the early signs of diseases are identified, and remote monitoring of the patient's health is carried out by the physician on time. This aids in improving the health condition of the people and reduces the severity of disorders. But, the security gap in HC remains unresolved, despite various advantages.</p><p><strong>Objective: </strong>This work proposes secured data communication in WSHN using Exponential Message Digest5 (EXP-MD5) and Diffie Hellman Secret Key-based Elliptic Curve Cryptography (DHSK-ECC) techniques.</p><p><strong>Methods: </strong>Primarily, the patient registers their details in the Hospital Cloud Server (HCS). With hospital ID and patient ID, public and private keys are generated during registration. Afterward, by utilizing the Navie Shuffling (NS) technique, nCr combinations are created and shuffled. After shuffling, any of the randomly selected combinations are encoded utilizing the American Standard Code for Information Interchange (ASCII) code. For patient authentication, the ASCII code is further converted into a Quick Response(QR) code. Upon successful registration, the patient logs in to HCS. The patient can book for doctor's appointment if the login details are verified with those of the registered details. On consulting the doctor at the pre-informed time, the digital signature is created utilizing the Universal Unique Salt-based Digital Signature Algorithm (UUS-DSA) for authenticating the patient details. Further, for providing accessibility to all the authorized patients, the registered patients on HCS are considered as nodes. Then, an authorized path is created using the EXP-MD5 technique to protect each individual patient's details. The patient's IoT data is sensed, followed by authorized path creation. The data is encrypted via the DHSK-ECC algorithm for secure data transmission. Lastly, all the information is stored in HCS, so that the patient's health condition is regularly monitored by the doctor and the needy advice is suggested to the patients in the future. Also, hash matching is carried out when the doctor needs to access data.</p><p><strong>Results: </strong>The proposed technique's efficacy is validated by the performance analysis in comparison with other conventional techniques.</p><p><strong>Conclusion: </strong>In this proposed research, the authentication is performed in multiple scenarios to enhance data security and user privacy. The patient details are authenticated during registration and verification to access the online consultation only by the authorized person. Further, the patient health information is encrypted in the proposed work aft
背景:在医疗保健(HC)领域,无线传感器医疗保健网络(WSHN)的使用正变得越来越重要。将传感器设备植入病人体内,通过移动设备、摄像头等数据聚合设备将病人的健康信息传送给医生。这样,医生就能及时发现疾病的早期征兆,并对病人的健康状况进行远程监控。这有助于改善人们的健康状况,降低疾病的严重程度。但是,尽管有各种优势,人机交互的安全漏洞仍未得到解决:本研究提出了在 WSHN 中使用指数信息摘要5(EXP-MD5)和基于椭圆曲线加密法的 Diffie Hellman 密钥(DHSK-ECC)技术进行安全数据通信的方法:首先,患者在医院云服务器(HCS)上注册自己的详细信息。在注册过程中,通过医院 ID 和患者 ID 生成公钥和私钥。然后,利用纳维洗牌(NS)技术,创建并洗牌 nCr 组合。洗牌后,随机选择的任何组合都将使用美国信息交换标准码(ASCII)进行编码。为了对患者进行身份验证,ASCII 码会进一步转换成快速反应(QR)码。注册成功后,患者即可登录 HCS。如果登录信息与注册信息核对无误,病人就可以预约医生。在预先告知的时间咨询医生后,将利用通用唯一盐基数字签名算法(UUS-DSA)创建数字签名,以验证病人的详细信息。此外,为了向所有授权患者提供访问权限,HCS 上的注册患者被视为节点。然后,使用 EXP-MD5 技术创建授权路径,以保护每位患者的详细信息。首先感知患者的物联网数据,然后创建授权路径。数据通过 DHSK-ECC 算法加密,以确保数据传输安全。最后,所有信息都存储在 HCS 中,以便医生定期监测患者的健康状况,并在未来向患者提出必要的建议。此外,当医生需要访问数据时,还会进行哈希匹配:结果:通过与其他传统技术的性能分析,验证了所提技术的有效性:在这项拟议的研究中,身份验证在多个场景中进行,以增强数据安全性和用户隐私。在注册和验证过程中对患者的详细信息进行验证,只有获得授权的人才能访问在线咨询。此外,在建议的工作中,病人的健康信息会在咨询后进行加密,以防止恶意用户入侵医疗记录和篡改数据。同时,通过创建授权路径,将从患者处收集到的感知数据传输到 HCS,这进一步增强了患者数据的安全性。因此,在这项工作中,通过多级认证和改进的加密技术,WSHN 的数据通信得到了很好的保障。
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引用次数: 0
Experimental study of magnetic hydrogel assisted magnetic anchorguided endoscopic submucosal dissection in colonic tumors. 磁性水凝胶辅助磁锚引导的结肠肿瘤内窥镜黏膜下剥离实验研究。
IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-08 DOI: 10.3233/THC-240653
Lin Cui, Xueyan Zhang, Yingying Wen, Cuihua Li, Jianyun Zhang, XiWei Cui, Hao Sun, Liu Chang

Background: Endoscopic submucosal dissection (ESD) is a well-established treatment for gastrointestinal tumors and enables en bloc resection. Adequate counter traction with good visualization is important for safe and effective dissection.

Objective: Based on magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD), we would like to explore the feasibility of magnetic hydrogel as an internal magnetic anchor that can be injected into the submucosa through an endoscopic needle to assist colonic endoscopic submucosal dissection.

Methods: This prospective trial was conducted on 20 porcine colons ex vivo. We injected magnetic hydrogel into submucosa of the porcine colons ex vivo for MAG-ESD to evaluate the traction effect and operation satisfaction.

Results: Magnetic hydrogel assisted ESD was successfully performed on 20 porcine colons ex vivo. Adequate counter traction with good visualization was successfully obtained during the procedure of dissection.

Conclusion: Magnetic hydrogel assisted MAG-ESD is feasible and effective.

背景:内镜下粘膜下剥离术(ESD)是一种行之有效的胃肠道肿瘤治疗方法,可进行全切。充分的反牵引和良好的可视性对于安全有效的剥离非常重要:基于磁锚引导的内镜黏膜下剥离术(MAG-ESD),我们想探索磁性水凝胶作为内磁锚的可行性,这种内磁锚可通过内镜针注入黏膜下,以辅助结肠内镜黏膜下剥离术:这项前瞻性试验在 20 个猪结肠体外进行。我们将磁性水凝胶注入猪结肠粘膜下,用于磁性水凝胶辅助结肠粘膜下剥离术,以评估牵引效果和手术满意度:结果:磁性水凝胶辅助ESD在20个猪结肠上成功实施。结果:磁性水凝胶辅助 ESD 在 20 头猪的体外结肠上成功实施,在解剖过程中成功获得了充分的反牵引力和良好的可视性:结论:磁性水凝胶辅助 MAG-ESD 是可行且有效的。
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引用次数: 0
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