Technology and Health Care最新文献_第6页

Influence of different forms of folic acid supplementation on pregnancy outcomes under various exposure factors. 在不同暴露因素下，不同形式的叶酸补充剂对妊娠结局的影响。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-241034

Jie Song,Ruihong Lan,Dahua Yin,Ling Wang,Humin Gong

BACKGROUNDFolic acid supplementation has been shown to provide benefits in preventing neural tube defects and other birth defects, as well as reducing adverse pregnancy outcomes.OBJECTIVEThis study aimed to examine the impact of various folic acid supplementation methods on pregnancy.METHODSTaqMan-MGB technology was used to detect polymorphisms in the folate metabolism-related genes, MTHFR C677T and A1298C. Blood-related biochemical indicators, including HCY levels and history of adverse pregnancy, were examined in relation to different exposure factors (MTHFR gene polymorphism, HCY levels, and adverse pregnancy history) and their impact on pregnancy outcomes. Various forms of folic acid intervention were implemented in a population with an adverse pregnancy history and high HCY levels to analyze the effects of reducing HCY levels and improving pregnancy outcomes.RESULTSExposure factors, such as adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were closely associated with pregnancy outcomes. Interestingly, methylfolate efficiently reduced the serum HCY levels. More importantly, the methylfolate group exhibited a significantly lower incidence of adverse pregnancies than the synthetic folic acid group.CONCLUSIONIn this study, the risk factors, including adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were confirmed to lead to the poorer pregnancy outcomes in our cohort. 5-methyltetrahydrofolate may be an effective approach for decreasing the incidence of adverse pregnancy outcomes.

背景补充叶酸已被证明对预防神经管畸形和其他出生缺陷以及减少不良妊娠结局有益处。血液相关生化指标（包括 HCY 水平和不良妊娠史）与不同暴露因素（MTHFR 基因多态性、HCY 水平和不良妊娠史）的关系及其对妊娠结局的影响进行了研究。结果不良妊娠史、HCY 和中高风险基因代谢等暴露因素与妊娠结局密切相关。有趣的是，甲叶酸能有效降低血清中的 HCY 水平。更重要的是，与合成叶酸组相比，甲叶酸组的不良妊娠发生率明显较低。5-甲基四氢叶酸可能是降低不良妊娠结局发生率的有效方法。

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引用次数: 0

A Bayesian network analysis of the probabilistic relationships between metabolically healthy obesity and cardiovascular disease risk under new diagnostic criteria. 新诊断标准下代谢健康肥胖与心血管疾病风险之间概率关系的贝叶斯网络分析。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-241472

Shuo Chen,Peixian Wu,Weiqun Peng,Hongai Zhang

BACKGROUNDThe relationship between metabolically healthy obesity (MHO) and cardiovascular disease (CVD) risk remains debated. The critical point may be the lack of consensus on MHO's definition and diagnostic criteria.OBJECTIVEThis study aimed to investigate the association of MHO status with arteriosclerosis-CVD (ASCVD) risk in Chinese under new diagnostic criteria.METHODSParticipants aged 35-79 in the 2009 China Health and Nutrition Survey cohort were included. The 10-year ASCVD risk was predicted by the prediction for ASCVD risk in China, and participants with a predicted risk of ⩾ 10% were classified into the high-risk group. The Bayesian network (BN) models were constructed to characterize the multivariable probabilistic connections between metabolically obesity phenotypes and ASCVD risk.RESULTSThe 10-year ASCVD risk score and the proportion of individuals at ASCVD high risk were significantly different between metabolically obesity phenotypes (P< 0.001). BN reasoning results showed that MHO individuals were not significantly associated with a 10-year ASCVD risk. Among metabolically unhealthy individuals, the conditional probability of high ASCVD risk increased with the Body Mass Index (BMI), with the conditional probability of high ASCVD risk was 24.63% (95% CI: 22.81-26.55%), 32.97% (95% CI: 30.75-35.27%) and 40.2% (95% CI: 36.64-43.86%) for metabolically unhealthy normal weight (MUNW), metabolically healthy overweight weight (MHOW), and metabolically unhealthy obesity (MUO) group, respectively. Subgroup analysis showed that MHO individuals were at increased risk of CVD compared with metabolically healthy normal weight (MHNW) individuals only in females.CONCLUSIONThese results showed that there was no significant increase in ASCVD risk of MHO phenotype based on the new diagnostic criteria, suggesting that MHO is in a relatively healthy state.

背景代谢性健康肥胖（MHO）与心血管疾病（CVD）风险之间的关系仍存在争议。本研究旨在根据新的诊断标准调查中国人的 MHO 状态与动脉硬化-心血管疾病（ASCVD）风险的关系。根据中国 ASCVD 风险预测法预测 10 年 ASCVD 风险，将预测风险⩾10% 的参与者归入高风险组。结果不同代谢肥胖表型之间的10年ASCVD风险评分和ASCVD高危人群比例存在显著差异（P< 0.001）。BN推理结果显示，MHO个体与10年ASCVD风险无明显关联。在代谢不健康个体中，ASCVD 高风险的条件概率随身体质量指数（BMI）的增加而增加，ASCVD 高风险的条件概率分别为 24.63% （95% CI：22.81-26.55%）、32.代谢不健康正常体重（MUNW）组、代谢健康超重体重（MHOW）组和代谢不健康肥胖（MUO）组的条件概率分别为 24.63% (95% CI: 22.81-26.55%)、32.97% (95% CI: 30.75-35.27%) 和 40.2% (95% CI: 36.64-43.86%)。亚组分析表明，与代谢健康的正常体重（MHNW）人群相比，MHO人群的心血管疾病风险仅在女性中有所增加。

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引用次数: 0

Nd: YAG laser irradiation in the treatment of live pulp preservation in pediatric cariogenic pulpitis. 掺钕钇钕石榴石（Nd: YAG）激光照射治疗小儿龋源性牙髓炎的活髓保存。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-241233

Mengxing Wang,Tian Xia,Ying Wang

BACKGROUNDDental pulpitis significantly impacts oral function and quality of life. Treatments like direct pulp capping aim to preserve pulp vitality.OBJECTIVEThis study aims to investigate the application value of Nd:YAG laser irradiation in preserving pulp vitality in children with caries-induced pulpitis.METHODSThis study, conducted from June 2019 to June 2023, included 89 children undergoing pulp vitality preservation treatment for caries-induced pulpitis. The children were divided into two groups using sealed envelopes: 44 in the control group received pulp capping treatment, while the study group received Nd:YAG laser-assisted pulp capping treatment. The efficacy, oral indicators, oral function, changes in root apex diameter and root length, changes in gingival crevicular fluid inflammatory factors, and incidence of complications were compared between the two groups before and 3 months after treatment.RESULTSThe total effective rates were 97.78% in the study group and 95.45% in the control group, with no significant difference between the groups (p> 0.05). Before treatment, there were no differences in gingival index, plaque index, and probing bleeding index between the groups (p> 0.05). After treatment, both groups showed decreased periodontal indexes compared to before treatment, with the study group showing lower values than the control group (p< 0.05). Chewing and biting function scores were similar between the groups before and after treatment (p> 0.05), but both groups showed decreased scores after treatment (p< 0.05). The study group had a higher percentage decrease in root apex diameter and a greater increase in root length compared to the control group (p< 0.05). During treatment, one case of tooth discoloration occurred in the study group (2.27%), while the control group had two cases of tooth discoloration and one case of secondary caries, resulting in a complication rate of 6.67%. There was no significant difference in the incidence of complications between the groups (p> 0.05).CONCLUSIONNd:YAG laser irradiation effectively preserves pulp vitality in children with caries-induced pulpitis, improving periodontal health, reducing root apex diameter, and increasing root length with high safety.

背景牙髓炎严重影响口腔功能和生活质量。本研究旨在探讨 Nd:YAG 激光照射在龋诱发牙髓炎儿童牙髓活力保存治疗中的应用价值。方法本研究于 2019 年 6 月至 2023 年 6 月进行，共纳入 89 名因龋诱发牙髓炎接受牙髓活力保存治疗的儿童。使用密封信封将儿童分为两组：对照组 44 名儿童接受牙髓封闭治疗，研究组接受 Nd:YAG 激光辅助牙髓封闭治疗。结果研究组总有效率为97.78%，对照组总有效率为95.45%，组间差异无显著性（P>0.05）。治疗前，两组的牙龈指数、牙菌斑指数和探诊出血指数无差异（P> 0.05）。治疗后，与治疗前相比，两组的牙周指数均有所下降，研究组的数值低于对照组（P< 0.05）。两组在治疗前后的咀嚼和咬合功能评分相似（P> 0.05），但两组在治疗后的评分均有所下降（P< 0.05）。与对照组相比，研究组的牙根顶直径减少的百分比更高，而牙根长度增加的百分比更大（P< 0.05）。在治疗过程中，研究组有一例牙齿变色（2.27%），而对照组有两例牙齿变色和一例继发性龋齿，并发症发生率为 6.67%。结论掺钕钇钕石榴石（YAG）激光照射可有效保护龋齿诱发牙髓炎患儿的牙髓活力，改善牙周健康，缩小根尖直径，增加根长，安全性高。

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引用次数: 0

Clinical efficacy of tension-free vaginal tape-ischiopubic ramus versus transobturator tension-free vaginal tape in the management of female stress urinary incontinence. 在治疗女性压力性尿失禁方面，无张力阴道胶带-髂耻骨横突与经尿道无张力阴道胶带的临床疗效对比。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-241247

Yingqing Ruan,Ping Liu,Minjie Qiu

BACKGROUNDStress urinary incontinence (SUI), a prevalent condition among middle-aged and elderly women in China, is characterized by the involuntary leakage of urine during instances of increased abdominal pressure [1]. Although SUI is not life-threatening, it substantially impacts patients' physical and psychological well-being, impairs their social interactions, and diminishes their overall quality of life.OBJECTIVEThe aim of this study was to evaluate and compare the clinical efficacy of tension-free vaginal tape-ischiopubic ramus (TVT-IR) and transobturator tension-free vaginal tape (TVT-O) in the treatment of female stress urinary incontinence (SUI).METHODSA retrospective analysis of clinical data from 83 female SUI patients was conducted, dividing them into a TVT-IR group (n= 41) and a TVT-O group (n= 42) based on the surgical procedures employed. Perioperative indices, surgical efficacy, complications, symptom improvement pre- and post-operation (3 months), urodynamic measurements, and indices related to pelvic floor function and quality of life were compared between the two groups.RESULTSThe TVT-IR group had significantly shorter operative time than the TVT-O group (P< 0.05). Three months after surgery, both groups had significantly lower frequency of incontinence, incontinence score, and number of nocturnal urination, significantly higher Pdet, ALPP, Qmax, and MUCP, significantly higher class I and class II fiber muscle strength and muscle potential, and significantly higher I-QOL scores (P< 0.05). The aforementioned indicators were superior in the TVT-IR group compared to the TVT-O group three months after surgery (P< 0.05).CONCLUSIONBoth TVT-IR and TVT-O are effective in treating SUI, with comparable complication rates.

背景压力性尿失禁（SUI）是中国中老年妇女的一种常见病，其特点是在腹压增加时不自主地漏尿[1]。本研究旨在评估和比较无张力阴道粘贴带-髂耻骨横突（TVT-IR）和经尿道无张力阴道粘贴带（TVT-O）治疗女性压力性尿失禁（SUI）的临床疗效。方法对 83 名女性 SUI 患者的临床数据进行回顾性分析，根据采用的手术方法将其分为 TVT-IR 组（41 人）和 TVT-O 组（42 人）。比较了两组患者的围手术期指标、手术疗效、并发症、手术前后（3 个月）症状改善情况、尿动力学测量结果以及盆底功能和生活质量相关指标。术后三个月，两组患者的尿失禁频率、尿失禁评分和夜尿次数均明显降低，Pdet、ALPP、Qmax和MUCP均明显提高，I级和II级纤维肌力和肌电位明显提高，I-QOL评分明显提高（P< 0.05）。术后三个月，TVT-IR 组的上述指标均优于 TVT-O 组（P< 0.05）。

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引用次数: 0

The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease. 冠状动脉内心电图在诊断冠心病心肌缺血中的价值和准确性。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-240837

Shanwen Zhang,Zhimin Bao,Taotao Liao,Zhenying Pei,Shiyu Yang,Chunjiao Zhao,Yuping Zhang

BACKGROUNDAlthough intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.OBJECTIVETo analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.METHODSThree hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] > 0.8) and ischemic group B (FFR < 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR > 0.8) and ischemic subgroup B2 (FFR < 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters.RESULTSGroup A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group (p< 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia (p< 0.05).CONCLUSIONIntracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.

背景虽然与心电图（ECG）等常见诊断方法相比，冠状动脉内心电图（IC-ECG）可直接从电生理角度了解冠状动脉供血不足导致的心肌缺血，但它缺乏广泛的应用和有力的临床研究。根据 FFR 检查结果，将患者分为非缺血 A 组（FFR > 0.8）和缺血 B 组（FFR < 0.75）。两组均接受 IC-ECG 检查。缺血组接受经皮冠状动脉介入（PCI）治疗，然后再次进行 FFR 检查，将其分为非缺血亚组 B1（FFR > 0.8）和缺血亚组 B2（FFR < 0.75）。两个亚组均接受了 IC-ECG 检查。结果 A组患者的J点ST段移位、ST段积分、T峰、T波积分和T峰至终点时间显著下降，而B组患者的校正Q-T间期（QTc-time）显著升高（P< 0.05）。结论冠状动脉心电图 QT 间期弥散和 Q-T 峰（QTp）间期弥散对冠心病心肌缺血有较高的诊断准确性。

{"title":"The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease.","authors":"Shanwen Zhang,Zhimin Bao,Taotao Liao,Zhenying Pei,Shiyu Yang,Chunjiao Zhao,Yuping Zhang","doi":"10.3233/thc-240837","DOIUrl":"https://doi.org/10.3233/thc-240837","url":null,"abstract":"BACKGROUNDAlthough intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.OBJECTIVETo analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.METHODSThree hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] > 0.8) and ischemic group B (FFR < 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR > 0.8) and ischemic subgroup B2 (FFR < 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters.RESULTSGroup A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group (p< 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia (p< 0.05).CONCLUSIONIntracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"4 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous glucose monitoring using machine learning models and IoT device data: A meta-analysis. 使用机器学习模型和物联网设备数据进行连续葡萄糖监测：荟萃分析

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-08-29 DOI: 10.3233/thc-241403

Yagyesh Kapoor,Yasha Hasija

BACKGROUNDMachine learning offers diverse options for effectively managing blood glucose levels in diabetes patients. Selecting the right ML algorithm is critical given the array of available choices. Integrating data from IoT devices presents promising opportunities to enhance real-time blood glucose management models.OBJECTIVEThis meta-analysis aims to evaluate the effectiveness of machine learning models utilizing IoT device data for predicting blood glucose levels.METHODSWe systematically searched electronic databases for studies published between 2019 and 2023. We excluded studies lacking ML model derivation or performance metrics. The Quality Assessment of Diagnostic Accuracy Studies tool assessed study quality. Our primary outcomes compared ML models for BG level prediction across different prediction horizons (PHs).RESULTSWe analyzed ten eligible studies across prediction horizons of 15, 30, 45, and 60 minutes. ML models exhibited mean absolute RMSE values of 15.02 (SD 1.45), 21.488 (SD 2.92), 30.094 (SD 3.245), and 35.89 (SD 6.4) mg/dL, respectively. Random Forest demonstrated superior performance across these PHs.CONCLUSIONWe observed significant heterogeneity across all subgroups, indicating diverse sources of variability. As the PH lengthened, the RMSE for blood glucose prediction by the ML model increased, with Random Forest showing the highest relative performance among the ML models.

背景机器学习为有效管理糖尿病患者的血糖水平提供了多种选择。在众多可用选择中，选择正确的 ML 算法至关重要。整合物联网设备的数据为增强实时血糖管理模型提供了大有可为的机会。目的本荟萃分析旨在评估利用物联网设备数据预测血糖水平的机器学习模型的有效性。方法我们系统地搜索了电子数据库中 2019 年至 2023 年间发表的研究。我们排除了缺乏 ML 模型推导或性能指标的研究。诊断准确性研究质量评估工具对研究质量进行了评估。我们的主要结果比较了不同预测范围（PHs）内预测血糖水平的 ML 模型。结果我们分析了 10 项符合条件的研究，预测范围分别为 15、30、45 和 60 分钟。ML 模型的平均绝对 RMSE 值分别为 15.02 (SD 1.45)、21.488 (SD 2.92)、30.094 (SD 3.245) 和 35.89 (SD 6.4) mg/dL。我们在所有亚组中观察到了显著的异质性，这表明变异性的来源多种多样。随着 PH 的延长，ML 模型预测血糖的均方根误差（RMSE）也在增加，而随机森林在 ML 模型中表现出最高的相对性能。

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引用次数: 0

The improvement of pain symptoms in patients with burning mouth syndrome through combined laser and medication therapy. 通过激光和药物联合疗法改善灼口综合征患者的疼痛症状。

IF 1.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-04-21 DOI: 10.3233/THC-248044

Xingcen Li, Qianpeng Li, Jinhan Li, Xiaoyi Wang, Huaxiu Zou, Shuyang Wang, Jingyi Fan

Background: The etiology of Burning Mouth Syndrome (BMS) remains unclear.

Objective: To explore the differences in the therapeutic efficacy of pain improvement between medication therapy and laser therapy in patients with BMS.

Methods: 45 BMS patients were randomly divided into three groups: The Combination therapy group (Group A, n= 15), The Medication therapy group (Group B, n= 15), and the Laser therapy group (Group C, n= 15). The pain condition of the patients was evaluated using the Numeric Rating Scale (NRS), and the improvement in pain before and after treatment was compared among the three groups.

Results: All three groups (A, B, and C) showed a significant reduction in NRS scores after treatment, with statistically significant differences observed among the different groups. Group A exhibited the most significant improvement, with a statistically significant difference before and after treatment.

Conclusion: Laser and medication therapy are effective methods for reducing oral burning pain * symptoms, and their combined use yields more significant therapeutic effects.

背景：烧灼感口腔综合征（BMS）的病因尚不清楚：烧灼感口腔综合征（BMS）的病因尚不清楚：方法：将 45 名 BMS 患者随机分为三组：联合治疗组（A 组，15 人）、药物治疗组（B 组，15 人）和激光治疗组（C 组，15 人）。采用数字评分量表（NRS）对患者的疼痛状况进行评估，并比较三组患者治疗前后的疼痛改善情况：结果：所有三组（A、B 和 C 组）的 NRS 评分在治疗后都有显著下降，不同组间的差异有统计学意义。结论：激光和药物治疗是一种有效的治疗方法：结论：激光和药物治疗是减轻口腔灼痛*症状的有效方法，两者联合使用可产生更显著的治疗效果。

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引用次数: 0

The improvement of pain symptoms in patients with burning mouth syndrome through combined laser and medication therapy. 通过激光和药物联合疗法改善灼口综合征患者的疼痛症状。

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-04-21 DOI: 10.3233/THC-248044

Xingcen Li, Qianpeng Li, Jinhan Li, Xiaoyi Wang, Huaxiu Zou, Shuyang Wang, Jingyi Fan

Background: The etiology of Burning Mouth Syndrome (BMS) remains unclear.

Objective: To explore the differences in the therapeutic efficacy of pain improvement between medication therapy and laser therapy in patients with BMS.

Methods: 45 BMS patients were randomly divided into three groups: The Combination therapy group (Group A, n= 15), The Medication therapy group (Group B, n= 15), and the Laser therapy group (Group C, n= 15). The pain condition of the patients was evaluated using the Numeric Rating Scale (NRS), and the improvement in pain before and after treatment was compared among the three groups.

Results: All three groups (A, B, and C) showed a significant reduction in NRS scores after treatment, with statistically significant differences observed among the different groups. Group A exhibited the most significant improvement, with a statistically significant difference before and after treatment.

Conclusion: Laser and medication therapy are effective methods for reducing oral burning pain * symptoms, and their combined use yields more significant therapeutic effects.

背景：烧灼感口腔综合征（BMS）的病因尚不清楚：烧灼感口腔综合征（BMS）的病因尚不清楚：方法：将 45 名 BMS 患者随机分为三组：联合治疗组（A 组，15 人）、药物治疗组（B 组，15 人）和激光治疗组（C 组，15 人）。采用数字评分量表（NRS）对患者的疼痛状况进行评估，并比较三组患者治疗前后的疼痛改善情况：结果：所有三组（A、B 和 C 组）的 NRS 评分在治疗后都有显著下降，不同组间的差异有统计学意义。结论：激光和药物治疗是一种有效的治疗方法：结论：激光和药物治疗是减轻口腔灼痛*症状的有效方法，两者联合使用可产生更显著的治疗效果。

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引用次数: 0

Special Section: Enabling Technologies for Healthcare 5.0 Guest Editors: Chi Lin, Chang Wu Yu and Ning Wang. 专栏：医疗保健 5.0 的使能技术特邀编辑：Chi Lin、Chang Wu Yu 和 Ning Wang：Chi Lin、Chang Wu Yu 和 Ning Wang。

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-01-01

引用次数: 0

An analysis of the efficacy of botulinum neurotoxin type a in treating cervical dystonia. A 型肉毒杆菌神经毒素治疗颈肌张力障碍的疗效分析。

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care

Pub Date : 2024-01-01 DOI: 10.3233/THC-231182

Xuan Zhou, Zhen-Fei Li, Xuan-Zhu Guo, Qiao Wei, Ya-Nan Niu, Meng Li, Jia-Ning Xia, Li-Ping Chen

Background: The first-line treatment for cervical dystonia (CD) consists of repeated intramuscular injections of botulinum toxin (BoNT). However, the efficacy in some patients may be unsatisfactory and they may discontinue treatment.

Objective: To examine the factors associated with the maximum rate of remission in patients with CD after initial botulinum neurotoxin type A (or botulinum toxin type A abbreviated as BTX-A or BoNT-A) treatment.

Methods: Patients with CD who received BoNT-A injections were evaluated using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Tsui scale, with follow-up endpoints lasting until the start of the second injection. Patients who did not receive a second injection of BoNT-A were followed up for at least 5 months. The maximum remission rates were determined using the lowest Tsui and TWSTRS total scores during the follow-up period. We obtained basic information about these patients such as age, gender, duration of disease, presence of additional disease, types of torticollis, presence of anxiety, depression, tremors, single-photon emission computed tomography (SPECT) findings, injected dose, and so on from their medical records.

Results: A total of 70 patients with CD participated in this study, with males comprising 35.7% (25 individuals) with an average age of 45 ± 14 years old. The duration of disease was an independent risk factor for determining whether a complete remission has been attained using the Tsui scale (odds ratio [OR] = 0.978, 95% confidence interval [CI]: 0.959-0.997, P= 0.026). The optimal cut-off point for predicting patients who were unable to achieve complete remission based on duration of disease was 7.5 months (AUG = 0.711). Patients with CD with additional disease had greater difficulty achieving complete remission than those with CD alone based on TWSTRS assessments (P= 0.049). During the study, approximately 17% of all participants reported experiencing adverse reactions that lasted between 1 to 3 weeks before disappearing.

Conclusion: BoNT is an effective and safe method for treating CD. The maximum remission rates of patients after their first injections are influenced by the duration of their disease. Thus, treatment using BoNT injections must be administered as soon as possible.

背景：颈肌张力障碍（CD）的一线治疗包括反复肌肉注射肉毒杆菌毒素（BoNT）。然而，部分患者的疗效可能并不令人满意，他们可能会中断治疗：目的：研究 CD 患者在首次接受 A 型肉毒杆菌神经毒素（或 A 型肉毒杆菌毒素，简称 BTX-A 或 BoNT-A）治疗后最大缓解率的相关因素：使用多伦多西方痉挛性皮肌痉挛评分量表（TWSTRS）和徐氏评分量表对接受BoNT-A注射的CD患者进行评估，随访终点持续到第二次注射开始。对未接受第二次注射 BoNT-A 的患者进行了至少 5 个月的随访。最大缓解率是根据随访期间最低的 Tsui 和 TWSTRS 总分确定的。我们从这些患者的病历中获得了他们的基本信息，如年龄、性别、病程、是否患有其他疾病、肢体扭转类型、是否患有焦虑症、抑郁症、震颤、单光子发射计算机断层扫描（SPECT）结果、注射剂量等：共有 70 名 CD 患者参与了此次研究，其中男性占 35.7%（25 人），平均年龄为 45±14 岁。根据徐氏评分法，病程是决定是否达到完全缓解的独立风险因素（几率比[OR] = 0.978，95% 置信区间[CI]：0.959-0.997）：0.959-0.997, P= 0.026).根据病程预测无法达到完全缓解的患者的最佳临界点为 7.5 个月（AUG = 0.711）。根据 TWSTRS 评估结果，伴有其他疾病的 CD 患者比单纯 CD 患者更难获得完全缓解（P= 0.049）。在研究过程中，约有 17% 的参与者报告出现了不良反应，这些不良反应持续了 1 到 3 周才消失：结论：BoNT 是治疗 CD 的一种有效而安全的方法。患者首次注射后的最大缓解率受病程长短的影响。因此，必须尽快进行 BoNT 注射治疗。

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引用次数: 0