Revista Portuguesa De Cardiologia最新文献

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Handgrip strength in Heart Failure: The "stethoscope" of the muscle? 心力衰竭的握力：肌肉的“听诊器”？

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-16 DOI: 10.1016/j.repc.2025.12.003

Jonathan Dos Santos

引用次数: 0

The first year of generic on-vitamin K oral anticoagulants: Implications for patients and the healthcare system. 非维生素K类口服抗凝剂的第一年：对患者和医疗保健系统的影响。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-13 DOI: 10.1016/j.repc.2025.10.004

Rita Barbosa Sousa, Afonso Félix de Oliveira, Eduardo Infante de Oliveira

引用次数: 0

Turning the heart around: Pacemaker implantation in Situs Inversus. 心脏转个身：起搏器植入逆位。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-08 DOI: 10.1016/j.repc.2025.08.009

Joana Certo Pereira, Isabel Santos, Francisco Gama, Pedro Adragão

引用次数: 0

Association between sarcopenia and quality of life in patients with heart failure. 心力衰竭患者肌肉减少症与生活质量的关系

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-08 DOI: 10.1016/j.repc.2025.09.008

Leonor P Silva, Luciana Silva, Inês Neves, Inês Soares, Raquel Moura, Diana Lucas, Catarina Pereira, Tiago Gregório, Joana Pimenta, Joana Mascarenhas

**Introduction and Objectives:** Sarcopenia, which is characterized by the loss of skeletal muscle mass and function, is prevalent among patients with heart failure (HF) and negatively impacts their quality of life (QoL). The purpose of this study was to test the hypothesis that reduced muscle strength, as measured by handgrip strength (HGS), is independently associated with poorer quality of life (QoL) in patients with heart failure (HF).

Methods: This cross-sectional study involved 114 patients with stable HF. HGS was assessed through a digital dynamometer; sarcopenia was defined by using gender-specific thresholds. Additional assessments included demographics, comorbidities, HF severity, frailty and QoL (the Kansas City Cardiomyopathy Questionnaire was used as a tool). To determine factors independently associated with QoL, a multiple linear regression model was obtained; we also derived a stepwise multiple linear regression model based on the Akaike Information Criteria.

Results: Average HGS was 20.9±8.4 kg and 54.5% of patients were classified as having probable sarcopenia. HGS demonstrated a positive correlation with QoL (r = 0.46, p<0.001) and negative correlation with the New York Heart Association classification and the Clinical Frailty Scale. Multivariate analysis revealed that a higher HGS, a younger age, a lower NYHA class and lower frailty scores were significantly associated with a better QoL. A 10 kg increase in HGS was associated with an 8.7-point rise in KCCQ-23 scores.

Conclusion: Handgrip strength is an independent predictor of QoL in patients with chronic HF. A regular assessment of HGS in clinical practice may help monitor the risk of sarcopenia and improve patient management, potentially enhancing daily functioning and QoL.

**简介与目的：**骨骼肌减少症是一种以骨骼肌质量和功能丧失为特征的疾病，在心力衰竭（HF）患者中普遍存在，并对其生活质量（QoL）产生负面影响。本研究的目的是验证一个假设，即通过握力（HGS）测量的肌肉力量减少与心力衰竭（HF）患者的生活质量（QoL）较差独立相关。方法：对114例稳定型心衰患者进行横断面研究。HGS通过数字测功机进行评估；骨骼肌减少症的定义采用性别特异性阈值。其他评估包括人口统计学、合并症、HF严重程度、虚弱和生活质量（使用堪萨斯城心肌病问卷作为工具）。为了确定与生活质量独立相关的因素，建立了多元线性回归模型；并基于赤池信息准则建立了逐步多元线性回归模型。结果：平均HGS为20.9±8.4 kg， 54.5%的患者为可能的肌肉减少症。HGS与生活质量呈正相关（r = 0.46, p）。结论：握力是慢性HF患者生活质量的独立预测因子。在临床实践中定期评估HGS可能有助于监测肌肉减少症的风险，改善患者管理，潜在地提高日常功能和生活质量。

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引用次数: 0

Insights on "Effectiveness of a cardiac rehabilitation program in women with heart failure". 关于“心力衰竭妇女心脏康复计划的有效性”的见解。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-05 DOI: 10.1016/j.repc.2025.11.005

Parth Aphale, Himanshu Shekhar, Shashank Dokania

引用次数: 0

Response to "Insights on Effectiveness of a cardiac rehabilitation program in women with heart failure". 对“对心力衰竭妇女心脏康复计划有效性的见解”的回应。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-04 DOI: 10.1016/j.repc.2025.12.001

Andreia Campinas

引用次数: 0

Gastrointestinal stromal tumor causing an eletrocardiogram mimic of cardiomyopathy 胃肠道间质瘤引起类似心肌病的心电图。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.08.004

Rita Almeida Carvalho , Ana Rita Bello , Pedro Lopes , Ana Coutinho Santos , Bruno M.L. Rocha

引用次数: 0

Carvedilol versus flecainide treatment in idiopathic ventricular extrasystoles and tachycardias (CARFLECT IV) trial: Rationale and design 卡维地洛与氟卡奈治疗特发性室性早搏和心动过速（CARFLECT IV）试验：理论基础和设计。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.07.004

Mauro Trincado Ave , María Brión , Brais Díaz Fernández , Alejandro Blanco-Verea , Teresa Cabaleiro Ocampo , Ana Estany Gestal , Carlos Tilves , María Moure González , Ana Seoane Blanco , Federico García-Rodeja , José Ramón González-Juanatey , Moisés Rodríguez Mañero

Introduction and objectives

Idiopathic symptomatic non-sustained ventricular arrhythmias (INVA), including premature ventricular contractions and non-sustained ventricular tachycardias, are generally considered benign. Symptoms and left ventricular dysfunction are indications for treatment with antiarrhythmic drugs. The SCN5A gene encodes part of the voltage-dependent sodium channel type V alpha, which is the primary target of flecainide. The H558R polymorphism of this gene has been associated with a better response to flecainide in atrial fibrillation. The aim of this study is to describe the protocol of the CARFLECT IV clinical trial, which will compare the efficacy of flecainide and carvedilol in reducing INVAs and their consequences, and to assess a potential interaction with the H558R polymorphism.

Methods

A randomized, third party-blinded, crossover trial will be conducted in adults with frequent INVAs. Each treatment will be administered for 12 weeks. Thirty-two patients will be recruited. The primary objectives are to compare the reduction in arrhythmia burden before and after each treatment, as well as to perform a subsequent multivariate analysis that accounts for potential interactions with the H558R polymorphism. Multiple secondary objectives have been established: changes in quality of life, left ventricular ejection fraction, global longitudinal strain, and the occurrence of adverse events.

Results

The results of the CARFLECT IV trial are not yet available.

Conclusions

This study will be the first clinical trial focused on adults with INVA. The information it provides may influence the choice of pharmacological therapy for the treatment of these arrhythmias.

简介和目的：特发性症状性非持续性室性心律失常（INVA），包括室性早搏和非持续性室性心动过速，通常被认为是良性的。症状和左心室功能障碍是抗心律失常药物治疗的适应症。SCN5A基因编码部分电压依赖性钠离子通道V α，这是氟氯胺的主要靶点。该基因的H558R多态性与房颤患者对氟氯胺的更好反应有关。本研究的目的是描述CARFLECT IV临床试验的方案，该试验将比较氟卡胺和卡维地洛在降低inva及其后果方面的疗效，并评估与H558R多态性的潜在相互作用。方法：一项随机、第三方盲、交叉试验将在频繁发生inva的成人中进行。每次治疗持续12周。将招募32名患者。主要目的是比较每次治疗前后心律失常负担的减少，并进行后续的多变量分析，以解释与H558R多态性的潜在相互作用。已经建立了多个次要目标：生活质量的改变、左心室射血分数、整体纵向应变和不良事件的发生。结果：CARFLECT IV试验的结果尚未公布。结论：该研究将是首个针对成人INVA的临床试验。它提供的信息可能会影响这些心律失常的药物治疗的选择。

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引用次数: 0

Navigating frequent idiopathic premature ventricular contractions: Lessons learned from clinical practice 导航频繁的特发性室性早搏：从临床实践中吸取的教训。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.11.001

Sérgio Barra

引用次数: 0

Prevalence of coronary anomalies in adolescent and young adults with D-transposition of great arteries after arterial switch operation 青少年和青壮年大动脉d转位术后冠状动脉异常的发生率

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.06.007

João Calvão , Mariana Vasconcelos , Catarina Costa , Ana Filipa Amador , André Carvalho , João Rebelo , Jorge Moreira , Cristina Cruz , Filipe Macedo

Background and purpose

Arterial switch operation (ASO) is currently the standard surgical repair for D-transposition of great arteries (D-TGA). As the procedure implies reimplantation of the coronary arteries into the neo-aortic root, long-term coronary complications are possible and potentially dangerous. However, routine coronary evaluation after ASO remains controversial. The purpose of this study is to perform a descriptive analysis of coronary computed tomography angiography (CCTA) findings in adolescent and young adults with D-TGA after ASO.

Methods

We performed a retrospective single center study that included adolescent and young adults with D-TGA submitted to ASO who underwent CCTA. Demographic, clinical and imaging data were collected.

Results

We identified 57 patients with D-TGA submitted to ASO. Of these, 39 performed a CCTA. Mean age of patients was 19.6 (±4.2) years; 54% were male; 32% had complex D-TGA. In 35 patients (90%), CCTA was part of routine screening. In four (10%) patients CCTA was done due to symptoms or an abnormal non-invasive test suggestive of myocardial ischemia. Eighteen (46%) patients had coronary anomalies: five (13%) had an acute angulation at the coronary origin; 13 (33%) patients had anomalous origin of the coronary arteries. Interarterial course was described in two (5%) patients and retroaortic course reported in eight (21%) cases.

Conclusions

Adolescent and young adults with D-TGA submitted to ASO have a high incidence of coronary anomalies. Routine screening with CCTA may be justified to identify patients who may be at higher risk of coronary events.

背景与目的材料转换手术（ASO）是目前大动脉d转位（D-TGA）的标准手术修复方法。由于该手术意味着将冠状动脉重新植入新主动脉根部，长期的冠状动脉并发症是可能的，并且具有潜在的危险。然而，ASO术后常规冠状动脉评估仍有争议。本研究的目的是对ASO后患有D-TGA的青少年和年轻人的冠状动脉计算机断层血管造影（CCTA）结果进行描述性分析。方法：我们进行了一项回顾性单中心研究，纳入了接受CCTA治疗的青少年和青年D-TGA患者。收集了人口统计学、临床和影像学资料。结果57例D-TGA患者接受ASO治疗。其中39例行CCTA。患者平均年龄19.6（±4.2）岁；54%为男性；32%为复合D-TGA。在35例（90%）患者中，CCTA是常规筛查的一部分。在4例（10%）患者中，由于症状或提示心肌缺血的非侵入性检查异常而进行CCTA。18例（46%）患者有冠状动脉异常：5例（13%）患者在冠状动脉起源处有急性成角；冠状动脉起源异常13例（33%）。2例（5%）患者有动脉间病程，8例（21%）患者有主动脉后病程。结论青少年和青壮年D-TGA合并ASO患者冠状动脉异常发生率高。用CCTA进行常规筛查可能是合理的，以确定可能有较高冠状动脉事件风险的患者。

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