Revista Portuguesa De Cardiologia最新文献

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Thrombosis and stenosis in externally supported saphenous vein grafts: Findings on cardiac computed tomography 体外支持隐静脉移植物的血栓形成和狭窄：心脏计算机断层扫描的发现。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2026-01-01 DOI: 10.1016/j.repc.2025.09.006

Lucia Fernandez Gasso , Martín Eiriz , Emilio Cuesta

引用次数: 0

Real-world Portuguese data on heart failure: The case of dapagliflozin 真实的葡萄牙心脏衰竭数据：达格列净的案例。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2026-01-01 DOI: 10.1016/j.repc.2025.11.003

Irene Marques

引用次数: 0

Acknowledgement Reviewers_2025 确认Reviewers_2025

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2026-01-01 DOI: 10.1016/j.repc.2025.12.002

引用次数: 0

Right ventricular outflow tract pseudoaneurysm in repaired of Tetralogy of Fallot CPT II遗传性缺乏所致的左室性心肌病。罕见诊断的关键。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2026-01-01 DOI: 10.1016/j.repc.2025.09.007

Swasthi S. Kumar , Usnish Adhikari , Deepa Sasikumar , V. Jineesh , Arun Gopalakrishnan

引用次数: 0

Impact of mechanical mitral prosthesis on transcatheter aortic valve implantation procedure 机械二尖瓣假体对经导管主动脉瓣植入术的影响。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2026-01-01 DOI: 10.1016/j.repc.2025.08.005

Joana Certo Pereira , Ana Rita Bello , Francisco Albuquerque , João Abecasis , Pedro de Araújo Gonçalves

引用次数: 0

Gastrointestinal stromal tumor causing an eletrocardiogram mimic of cardiomyopathy 胃肠道间质瘤引起类似心肌病的心电图。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.08.004

Rita Almeida Carvalho , Ana Rita Bello , Pedro Lopes , Ana Coutinho Santos , Bruno M.L. Rocha

引用次数: 0

Carvedilol versus flecainide treatment in idiopathic ventricular extrasystoles and tachycardias (CARFLECT IV) trial: Rationale and design 卡维地洛与氟卡奈治疗特发性室性早搏和心动过速（CARFLECT IV）试验：理论基础和设计。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.07.004

Mauro Trincado Ave , María Brión , Brais Díaz Fernández , Alejandro Blanco-Verea , Teresa Cabaleiro Ocampo , Ana Estany Gestal , Carlos Tilves , María Moure González , Ana Seoane Blanco , Federico García-Rodeja , José Ramón González-Juanatey , Moisés Rodríguez Mañero

Introduction and objectives

Idiopathic symptomatic non-sustained ventricular arrhythmias (INVA), including premature ventricular contractions and non-sustained ventricular tachycardias, are generally considered benign. Symptoms and left ventricular dysfunction are indications for treatment with antiarrhythmic drugs. The SCN5A gene encodes part of the voltage-dependent sodium channel type V alpha, which is the primary target of flecainide. The H558R polymorphism of this gene has been associated with a better response to flecainide in atrial fibrillation. The aim of this study is to describe the protocol of the CARFLECT IV clinical trial, which will compare the efficacy of flecainide and carvedilol in reducing INVAs and their consequences, and to assess a potential interaction with the H558R polymorphism.

Methods

A randomized, third party-blinded, crossover trial will be conducted in adults with frequent INVAs. Each treatment will be administered for 12 weeks. Thirty-two patients will be recruited. The primary objectives are to compare the reduction in arrhythmia burden before and after each treatment, as well as to perform a subsequent multivariate analysis that accounts for potential interactions with the H558R polymorphism. Multiple secondary objectives have been established: changes in quality of life, left ventricular ejection fraction, global longitudinal strain, and the occurrence of adverse events.

Results

The results of the CARFLECT IV trial are not yet available.

Conclusions

This study will be the first clinical trial focused on adults with INVA. The information it provides may influence the choice of pharmacological therapy for the treatment of these arrhythmias.

简介和目的：特发性症状性非持续性室性心律失常（INVA），包括室性早搏和非持续性室性心动过速，通常被认为是良性的。症状和左心室功能障碍是抗心律失常药物治疗的适应症。SCN5A基因编码部分电压依赖性钠离子通道V α，这是氟氯胺的主要靶点。该基因的H558R多态性与房颤患者对氟氯胺的更好反应有关。本研究的目的是描述CARFLECT IV临床试验的方案，该试验将比较氟卡胺和卡维地洛在降低inva及其后果方面的疗效，并评估与H558R多态性的潜在相互作用。方法：一项随机、第三方盲、交叉试验将在频繁发生inva的成人中进行。每次治疗持续12周。将招募32名患者。主要目的是比较每次治疗前后心律失常负担的减少，并进行后续的多变量分析，以解释与H558R多态性的潜在相互作用。已经建立了多个次要目标：生活质量的改变、左心室射血分数、整体纵向应变和不良事件的发生。结果：CARFLECT IV试验的结果尚未公布。结论：该研究将是首个针对成人INVA的临床试验。它提供的信息可能会影响这些心律失常的药物治疗的选择。

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引用次数: 0

Navigating frequent idiopathic premature ventricular contractions: Lessons learned from clinical practice 导航频繁的特发性室性早搏：从临床实践中吸取的教训。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.11.001

Sérgio Barra

引用次数: 0

Prevalence of coronary anomalies in adolescent and young adults with D-transposition of great arteries after arterial switch operation 青少年和青壮年大动脉d转位术后冠状动脉异常的发生率

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.06.007

João Calvão , Mariana Vasconcelos , Catarina Costa , Ana Filipa Amador , André Carvalho , João Rebelo , Jorge Moreira , Cristina Cruz , Filipe Macedo

Background and purpose

Arterial switch operation (ASO) is currently the standard surgical repair for D-transposition of great arteries (D-TGA). As the procedure implies reimplantation of the coronary arteries into the neo-aortic root, long-term coronary complications are possible and potentially dangerous. However, routine coronary evaluation after ASO remains controversial. The purpose of this study is to perform a descriptive analysis of coronary computed tomography angiography (CCTA) findings in adolescent and young adults with D-TGA after ASO.

Methods

We performed a retrospective single center study that included adolescent and young adults with D-TGA submitted to ASO who underwent CCTA. Demographic, clinical and imaging data were collected.

Results

We identified 57 patients with D-TGA submitted to ASO. Of these, 39 performed a CCTA. Mean age of patients was 19.6 (±4.2) years; 54% were male; 32% had complex D-TGA. In 35 patients (90%), CCTA was part of routine screening. In four (10%) patients CCTA was done due to symptoms or an abnormal non-invasive test suggestive of myocardial ischemia. Eighteen (46%) patients had coronary anomalies: five (13%) had an acute angulation at the coronary origin; 13 (33%) patients had anomalous origin of the coronary arteries. Interarterial course was described in two (5%) patients and retroaortic course reported in eight (21%) cases.

Conclusions

Adolescent and young adults with D-TGA submitted to ASO have a high incidence of coronary anomalies. Routine screening with CCTA may be justified to identify patients who may be at higher risk of coronary events.

背景与目的材料转换手术（ASO）是目前大动脉d转位（D-TGA）的标准手术修复方法。由于该手术意味着将冠状动脉重新植入新主动脉根部，长期的冠状动脉并发症是可能的，并且具有潜在的危险。然而，ASO术后常规冠状动脉评估仍有争议。本研究的目的是对ASO后患有D-TGA的青少年和年轻人的冠状动脉计算机断层血管造影（CCTA）结果进行描述性分析。方法：我们进行了一项回顾性单中心研究，纳入了接受CCTA治疗的青少年和青年D-TGA患者。收集了人口统计学、临床和影像学资料。结果57例D-TGA患者接受ASO治疗。其中39例行CCTA。患者平均年龄19.6（±4.2）岁；54%为男性；32%为复合D-TGA。在35例（90%）患者中，CCTA是常规筛查的一部分。在4例（10%）患者中，由于症状或提示心肌缺血的非侵入性检查异常而进行CCTA。18例（46%）患者有冠状动脉异常：5例（13%）患者在冠状动脉起源处有急性成角；冠状动脉起源异常13例（33%）。2例（5%）患者有动脉间病程，8例（21%）患者有主动脉后病程。结论青少年和青壮年D-TGA合并ASO患者冠状动脉异常发生率高。用CCTA进行常规筛查可能是合理的，以确定可能有较高冠状动脉事件风险的患者。

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引用次数: 0

Exercise stress testing in the 21st century 21世纪的运动压力测试。

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia

Pub Date : 2025-12-01 DOI: 10.1016/j.repc.2025.05.009

Hélder Dores , Miguel Mendes , Paulo Dinis , Eduardo Vilela

Until recent decades, exercise testing with electrocardiographic monitoring (ET) was a fundamental test to evaluate individuals with suspected or known cardiovascular disease (CVD). Since its inception, the landscape of CVD has profoundly changed; classical indications such as the diagnosis of ischemic heart disease have been progressively superseded by other modalities. ET can still, however, provide valuable data across the cardiovascular continuum. In this focused two-part article, we appraise the role of ET in contemporary settings: part I provides an overview of core parameters, while part II addresses select main areas of interest.

直到最近几十年，运动试验与心电图监测（ET）是评估疑似或已知心血管疾病（CVD）个体的基本测试。自成立以来，心血管疾病的格局发生了深刻的变化；经典适应症，如缺血性心脏病的诊断已逐渐被其他模式所取代。然而，ET仍然可以为心血管连续体提供有价值的数据。在这篇主要由两部分组成的文章中，我们评估了ET在当代环境中的作用：第一部分概述了核心参数，而第二部分则选择了主要感兴趣的领域。

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