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Asking Better Questions 提出更好的问题
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/mpuls.2023.3243317
N. Tsai
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引用次数: 0
Next-Generation Bioprinted Products: Products of Nature or Patentable Innovation? 下一代生物打印产品：自然产品还是专利创新产品？
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/MPULS.2023.3243318
Jennie O Zheng, S Sean Tu, Stephen B Maebius

Bioprinting is an additive manufacturing process used to create architectures that mimic natural living tissues in form and function [1]. It involves the deposition of bioink, which can include a mixture of living cells, nutrients, and extracellular matrix. The bioink is then deposited onto a scaffold to generate 3-D structures that imitate natural tissues and organs. This process has already been used to generate a diverse range of products, including bioprinted human ears for transplant, and 3-D printed bioceramic and modified biopolymer bone implants that received U.S. Food and Drug Administration (FDA) marketing approval [2] Researchers are working on bioprinted versions of a wide range of organs, including liver, kidney, lung, and heart.

生物打印是一种增材制造工艺，用于创建在形式和功能上模仿自然活体组织的结构[1]。它涉及生物墨水的沉积，生物墨水可以包括活细胞、营养物质和细胞外基质的混合物。然后将生物墨水沉积在支架上，生成模仿自然组织和器官的三维结构。这一过程已经被用于生产各种各样的产品，包括用于移植的生物打印人耳，以及获得美国食品药品监督管理局（FDA）上市批准的3D打印生物陶瓷和改性生物聚合物骨植入物[2]研究人员正在研究包括肝、肾、肺和心脏在内的多种器官的生物打印版本。
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引用次数: 0
The Yin and the Yang of New Technologies 新技术的阴阳
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/mpuls.2023.3243321
A. Johnson
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引用次数: 0
Identifying Problems and Unmet Clinical Needs: Who to Talk to and Where to Look 识别问题和未满足的临床需求:与谁交谈，去哪里看
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/mpuls.2023.3243322
J. Goldberg
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引用次数: 0
Double Vision: Study of U.K. Twins Provides New Insight Into Human Wellbeing. 双重愿景：英国双胞胎研究为人类健康提供了新的视角。
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/MPULS.2023.3243314
Jim Banks

Back in 1992, when Prof. Tim Spector of King's College London set up a study to investigate the incidence of osteoporosis and other rheumatologic diseases in monozygotic (identical) twins, little did he know how much the project would expand its horizons. From a few hundred identical twins, the cohort has grown to more than 15,000 identical and nonidentical twins across the U.K., aged between 18 and 100, and a host of diseases and conditions are under the microscope (Figure 1). Now, TwinsUK has one of the most deeply characterized adult twin cohorts anywhere in the world, providing vast quantities of data for longitudinal studies of health and aging.

早在1992年，当伦敦国王学院的Tim Spector教授开展了一项研究，调查单卵（同卵）双胞胎骨质疏松症和其他风湿病的发病率时，他几乎不知道这个项目会在多大程度上拓展视野。从几百对同卵双胞胎，英国的同卵和非同卵双胞胎已经发展到15000多对，年龄在18岁到100岁之间，许多疾病和病症都在显微镜下观察（图1）。现在，TwinsUK拥有世界上特征最深刻的成年双胞胎队列之一，为健康和衰老的纵向研究提供了大量数据。
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引用次数: 0
Engineering a Holistic Response to the Global Crisis of Forced Displacement. 对全球被迫流离失所危机作出全面反应。
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/MPULS.2023.3243319
Muhammad Hamid Zaman

The global coronavirus pandemic has demonstrated the necessity of engineering approaches, from research and development to rapid prototyping and production, in saving lives all across the world [1]. From personal protective equipment design to vaccine production and distribution, engineering has been the bedrock of an effective global response. However, despite major gains made in the last several decades, there are still millions all across the world, including the vulnerable displaced, who rarely benefit from new developments at the interface of engineering, biology, and health.

全球冠状病毒大流行证明了从研发到快速原型设计和生产的工程方法在拯救世界各地生命方面的必要性[1]。从个人防护设备设计到疫苗生产和分发，工程一直是全球有效应对措施的基石。然而，尽管在过去几十年中取得了重大进展，但世界各地仍有数百万人，包括弱势流离失所者，他们很少从工程、生物学和卫生领域的新发展中受益。
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引用次数: 1
Model Systems in Biology: History, Philosophy, and Practical Concerns 生物学中的模型系统:历史、哲学和实践问题
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/mpuls.2023.3243323
P. King
Georg F. Striedter is a professor of neurobiology and behavior in the School of Biological Sciences at University of California at Irvine, Irvine, CA, USA. His career-long research interest “in the evolution of vertebrate brains and behavior” has led him to accept “the challenge of synthesizing experimental data that are already published” (quotes from his personal website, https://www.faculty.uci.edu/profile.cfm?faculty_id=3006).
Georg F.Striedter是美国加利福尼亚州欧文市加利福尼亚大学生物科学学院的神经生物学和行为学教授。他对“脊椎动物大脑和行为的进化”的长期研究兴趣使他接受了“合成已经发表的实验数据的挑战”（引用自他的个人网站，https://www.faculty.uci.edu/profile.cfm?faculty_id=3006)。
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引用次数: 0
Insights Into Health Care Innovation and the Future of EMBS 医疗保健创新与EMBS的未来
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/mpuls.2023.3243320
M. Akay
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引用次数: 0
Advances in Microscopy Tech Offer Better Views. 显微镜技术的进步提供了更好的视角。
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2023-01-01 DOI: 10.1109/MPULS.2023.3243316
Leslie Mertz

Microscopes have come a very long way since the 1600s when Henry Power, Robert Hooke, and Anton van Leeuwenhoek began publishing the first views of plant cells and bacteria. The major inventions of contrast, electron, and scanning tunneling microscopes didn't arrive until the 20th century, and the men behind them all earned Nobel Prizes in physics for their efforts. Today, innovations in microscopy are coming at a fast and furious rate with new technologies providing first-time views and information about biological structures and activity, and opening up new avenues for disease therapies.

自17世纪亨利·鲍尔、罗伯特·胡克和安东·范·列文虎克首次发表植物细胞和细菌的观点以来，显微镜已经走过了很长的路。对比显微镜、电子显微镜和扫描隧道显微镜等重大发明直到20世纪才出现，这些发明的发明者都因此获得了诺贝尔物理学奖。今天，显微镜技术的创新正以迅猛的速度进行，新技术提供了关于生物结构和活动的第一次视图和信息，并为疾病治疗开辟了新的途径。
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引用次数: 0
The Future of Brain-Computer Interfaces. 脑机接口的未来。
IF 0.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
IEEE Pulse
Pub Date : 2022-11-01 DOI: 10.1109/MPULS.2022.3227806
Zara Abrams

Operating a drone, playing video games, or controlling a robot simply by thinking are exciting applications of brain-computer interfaces (BCIs) that pave the way for more mind-bending breakthroughs. Crucially, BCIs, which enable the brain to exchange signals with an outside device, also represent a powerful tool to restore movement, speech, touch, and other functions to patients with brain damage. Despite recent progress in the field, technological innovation is needed and plenty of scientific and ethical questions remain unanswered. Still, researchers say BCIs hold great promise for patients with the most severe impairments-and that major breakthroughs are within reach.

操作无人机、玩视频游戏，或者仅仅通过思考来控制机器人，这些都是脑机接口(bci)令人兴奋的应用，为更多令人费解的突破铺平了道路。至关重要的是，脑机接口使大脑能够与外部设备交换信号，也是一种强大的工具，可以恢复脑损伤患者的运动、语言、触觉和其他功能。尽管该领域最近取得了进展，但仍需要技术创新，许多科学和伦理问题仍未得到解答。尽管如此，研究人员表示，脑机接口对最严重损伤的患者有很大的希望，而且重大突破指日可待。
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引用次数: 0
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