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Current Problems in Pediatric and Adolescent Health Care最新文献

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Advances in big data and omics: Paving the way for discovery in childhood epilepsies 大数据和全息技术的进步:为发现儿童癫痫铺平道路。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-08-01 DOI: 10.1016/j.cppeds.2024.101634

The insights gained from big data and omics approaches have transformed the field of childhood genetic epilepsy. With an increasing number of individuals receiving genetic testing for seizures, we are provided with an opportunity to identify clinically relevant subgroups and extract meaningful observations from this large-scale clinical data. However, the volume of data from electronic medical records and omics (e.g., genomics, transcriptomics) is so vast that standardized methods, such as the Human Phenotype Ontology, are necessary for reliable and comprehensive characterization. Here, we explore the integration of clinical and omics data, highlighting how these approaches pave the way for discovery in childhood epilepsies.

从大数据和全息方法中获得的洞察力改变了儿童遗传性癫痫领域。随着越来越多的人接受癫痫发作基因检测,我们有机会识别与临床相关的亚组,并从这些大规模临床数据中提取有意义的观察结果。然而,来自电子病历和omics(如基因组学、转录组学)的数据量是如此庞大,以至于标准化方法(如人类表型本体)对于可靠和全面的特征描述是必不可少的。在此,我们将探讨临床数据与全息数据的整合,重点介绍这些方法如何为儿童癫痫的发现铺平道路。
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引用次数: 0
FOREWORD: Innovation in Managing Childhood Epilepsy-Part-2 前言:管理儿童癫痫的创新--第二部分。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-08-01 DOI: 10.1016/j.cppeds.2024.101654
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引用次数: 0
Editorial Board Page 编辑委员会页面
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-08-01 DOI: 10.1016/S1538-5442(24)00118-4
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引用次数: 0
The role of psychology and neuropsychology in pediatric epilepsy surgery evaluation 心理学和神经心理学在小儿癫痫手术评估中的作用。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-08-01 DOI: 10.1016/j.cppeds.2024.101592

Epilepsy is one of the most common neurological problems affecting 470,000 children in the United States. While most youth will achieve seizure freedom using medication, up to a third will continue to have seizures and are therefore considered to have drug-resistant epilepsy (DRE). Children and adolescents with epilepsy are at higher risk of behavioral, cognitive, and emotional disorders. Youth with DRE are at even greater risk of behavioral and emotional problems impacting quality of life and may need to pursue surgical interventions, including resective surgery or device implantation. Due to advances in the evaluation of candidates and surgical options, epilepsy surgery is more effective and has become second-line treatment for youth with DRE. This paper highlights the importance of exploring, assessing, and treating psychological and neuropsychological factors throughout the three phases of the epilepsy surgery process and ways pediatricians can support youth and families.

癫痫是最常见的神经系统问题之一,影响着美国 470,000 名儿童。虽然大多数青少年可以通过药物治疗摆脱癫痫发作,但仍有多达三分之一的青少年会继续有癫痫发作,因此被认为患有耐药性癫痫 (DRE)。患有癫痫的儿童和青少年患行为、认知和情感障碍的风险更高。患有 DRE 的青少年出现行为和情绪问题的风险更大,会影响生活质量,可能需要采取外科干预措施,包括切除手术或植入装置。由于候选者评估和手术选择方面的进步,癫痫手术更加有效,已成为罹患哆嗦性癫痫的青少年的二线治疗方法。本文强调了在癫痫手术过程的三个阶段中探索、评估和治疗心理和神经心理学因素的重要性,以及儿科医生为青少年和家庭提供支持的方法。
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引用次数: 0
Advanced approaches in Pediatric Epilepsy surgery 小儿癫痫手术的先进方法。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.cppeds.2024.101575
Michael E. Baumgartner PhD , Kathleen Galligan MS, PA-C , Benjamin C. Kennedy MD

While recent technological advancements are reshaping the landscape of surgical epilepsy management, the established techniques of resective and disconnective surgeries guided by electrographic monitoring remain the workhorse interventions for the management of refractory seizures and have the highest likelihood of achieving complete seizure resolution. Here we discuss examples of recent developments in surgical approaches and techniques for resective and disconnective surgeries with discussion of their indications and potential advantages.

虽然最近的技术进步正在重塑癫痫外科治疗的格局,但在电图监测指导下进行切除性和断开性手术的成熟技术仍然是治疗难治性癫痫发作的主要干预手段,而且最有可能实现癫痫发作的完全控制。在此,我们将举例说明切除性和断开性手术方法和技术的最新进展,并讨论其适应症和潜在优势。
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引用次数: 0
A pediatrician's guide to epilepsy surgery 儿科医生的癫痫手术指南。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.cppeds.2024.101578
Ania Dabrowski MD, PhD, Caren Armstrong MD, PhD

Surgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate interventions have prompted an interest in ensuring that all providers who see patients with epilepsy are aware of the options for epilepsy surgery to facilitate earlier referrals when medications have not been effective3 In this article, we will introduce the pediatrician to the process involved in determining epilepsy surgery candidacy and to surgical outcomes, with the goal of empowering pediatric providers to refer their medically refractory epilepsy patients to a pediatric epilepsy center.

癫痫手术治疗兴起于 20 世纪下半叶,是药物难治性癫痫小儿患者的重要选择。在过去 30 年里,接受癫痫外科手术的患者人数和可用的癫痫外科手术程序都在不断扩大,现在的手术范围从外科切除术到神经调节装置置入术1,2。研究显示,许多非常适合接受外科手术的患者仍然没有得到适当的干预,这促使人们希望确保所有为癫痫患者看病的医疗服务提供者都了解癫痫外科手术的选择,以便在药物治疗无效时尽早转诊3、在本文中,我们将向儿科医生介绍确定癫痫手术候选资格所涉及的过程以及手术结果,目的是让儿科医疗服务提供者有能力将他们的药物难治性癫痫患者转介到儿科癫痫中心。
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引用次数: 0
An overview of responsive neurostimulation for the pediatrician 儿科医生响应性神经刺激概述。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.cppeds.2024.101622
Michelle Han MD , Marissa P. DiGiovine MD , Caren Armstrong MD, PhD
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引用次数: 0
An overview of responsive neurostimulation for the pediatrician. 儿科医生响应性神经刺激概述。
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1016/j.cppeds.2024.101622
Michelle Han, Marissa P DiGiovine, Caren Armstrong
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引用次数: 0
Editorial Board Page 编辑委员会页面
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/S1538-5442(24)00110-X
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引用次数: 0
An introduction to epilepsy care 癫痫护理简介
IF 3 4区 医学 Q1 PEDIATRICS Pub Date : 2024-07-01 DOI: 10.1016/j.cppeds.2024.101591
Whitney Fitts MD, Shavonne L. Massey MD, MSCE, Jillian L. McKee MD, PhD, Marisa S. Prelack MD
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引用次数: 0
期刊
Current Problems in Pediatric and Adolescent Health Care
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