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[Two rare brain malformations in black and white German Holstein calves]. [两种罕见的脑畸形在黑色和白色的德国荷斯坦小牛]。
Bettina Constanze Buck, Reiner Ulrich, Anne Wöhlke, Heidi Kuiper, Marion Hewicker-Trautwein, Ottmar Distl

Two black and white female German Holstein calves showed malformations of the cerebrum. The first calf exhibited a cystencephaly and the second calf a meningoencephalocele. The animals originated from two different dairy farms. Both calves were sired by two unrelated sires used in artificial insemination. The calf affected by cystencephaly was lacking the corpus callosum which may had been caused the cystencephaly. Exept for a pressure atrophy, the remaining parts of the brain were macroscopically and histologically inconspicious. Histological examination of the cerebrum, brain stem and cerebellum in the second calf did not reveal specific changes. A further finding in the second calf was a unilateral anophthalmia. Both animals were affected by additional defects in the spinal column including brachyuria, duplications and fusions of vertebral bodies and rips as well as malformations of the heart such as ventricular-septal defects. Only mild clinical symptoms could be observed in both calves. The calves were not inbred and further calves affected by the identical anomalies could not be ascertained at the farms where the calves were born. Chromosomal anomalies could not be detected after examination of metaphase spreads using light microscopy.

两只黑白相间的德国荷斯坦母牛犊显示出大脑畸形。第一只小牛表现为囊性脑畸形,第二只小牛表现为脑膜脑膨出。这些动物来自两个不同的奶牛场。这两只小牛都是由两个不相关的母猪在人工授精中产生的。患囊性脑畸形的小牛胼胝体缺失,这可能是导致囊性脑畸形的原因。除了压力性萎缩外,其余脑区在宏观和组织学上都不明显。第二只小牛的大脑、脑干和小脑的组织学检查未发现特异性变化。第二只小牛的进一步发现是单侧眼无炎。这两种动物都受到脊柱其他缺陷的影响,包括短尿、椎体的重复和融合、撕裂以及心脏畸形,如心室-间隔缺陷。在两只小牛中均可观察到轻微的临床症状。这些小牛不是近亲繁殖的,在小牛出生的农场无法确定受相同异常影响的其他小牛。在光镜检查中期播散后未发现染色体异常。
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引用次数: 0
[Mass culling in the context of animal disease outbreaks--veterinarians caught between ethical issues and control policies]. [动物疾病爆发背景下的大规模扑杀——兽医在伦理问题和控制政策之间进退两难]。
Pub Date : 2009-04-01 DOI: 10.2376/0341-6593-116-152
S. Hartnack, M. Doherr, H. Grimm, P. Kunzmann
In recent years controversial discussions arose during major animal disease outbreaks in the EU about the ethical soundness of mass culling. In contrast to numerous publications about ethical issues and laboratory animals/animal experiments, literature concerning ethical deliberations in the case of mass culling as a means of outbreak control remain scarce. Veterinarians in charge of decision about and implementation of mass culling actions find themselves in an area of conflict in between the officially required animal disease control policy and a public that is increasingly critical. Those veterinarians are faced with the challenge to defend the relevant decisions against all stakeholders and also themselves. In this context an interdisciplinary workshop was initiated in Switzerland in October 2007 with ethicians and (official) veterinarians from Germany, Switzerland and Austria. With the aim to identify ethical components of animal disease control for official veterinarians, talks and moderated group discussions took place. This article summarizes selected discussion points and conclusions.
近年来,在欧盟爆发重大动物疾病期间,关于大规模扑杀的伦理合理性的争议性讨论出现了。与关于伦理问题和实验室动物/动物实验的众多出版物相比,关于大规模扑杀作为控制疫情手段的伦理审议的文献仍然很少。负责决定和实施大规模扑杀行动的兽医发现自己处于官方要求的动物疾病控制政策与日益重要的公众之间的冲突中。这些兽医面临着对所有利益相关者和他们自己捍卫相关决定的挑战。在此背景下,2007年10月在瑞士发起了一个跨学科研讨会,与会者包括来自德国、瑞士和奥地利的伦理学家和(官方)兽医。为了确定官方兽医控制动物疾病的伦理因素,举行了会谈和主持小组讨论。本文总结了选定的讨论点和结论。
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引用次数: 7
[Assessment of a Bullterrier bloodline in the temperament test of Lower Saxony--comparison with six dog breeds affected by breed specific legislation and a control group of Golden Retrievers]. [对下萨克森州斗牛犬血统气质测试的评估-与受品种特定立法影响的六个犬种和金毛猎犬对照组的比较]。
Stefanie Ott, Esther Schalke, Jennifer Hirschfeld, Hansjoachim Hackbarth

The expertise on the interpretation of section 11b TierSchG implies a hypertrophy of aggressive behaviour in some bloodlines of Bullterriers, American Staffordshire Terriers, and Pitbull type dogs. This study aimed at finding out whether a hypertrophy of aggressive behaviour occurred in a certain Bullterrier bloodline. Dogs of this line were tested according to the guidelines of the Dangerous Animals Act of Lower Saxony, Germany (GefTVO) enacted on July 5th 2000. The Bullterriers' test results towards humans and environment were compared to those of 415 dogs affected by the legislation (Mittmann, 2002) and those of 70 Golden Retrievers (Johann, 2004) in order to detect possible differences in the occurrence of inadequate or disturbed aggressive behaviour. Of 38 Bullterriers, ten showed no aggressive behaviour towards humans and the environment. 27 dogs displayed visual or acoustic threats at most. Only one dog reacted by "biting or attacking with preceding threatening behaviour". Thus, according to the test guidelines, 37 dogs (97.37%) reacted appropriately in all test situations. Only one dog (2.63%) displayed inadequate agressive behaviour. No indication for inadequate or disturbed aggressive behaviour in this Bullterrier bloodline was found. Furthermore, no significant differences were found when comparing Bullterriers and dogs of the two others studies concerning inadequate or disturbed aggressive towards humans and the environment. On the contrary, throughout the entire study the broad majority of dogs proved to possess excellent social skills as well as the ability to communicate competently and to solve conflicts appropriately.

对第11b条TierSchG的解释表明,在某些血统的牛头梗、美国斯塔福德梗和斗牛犬中,攻击性行为过度。这项研究的目的是找出是否在某种斗牛犬血统中发生了攻击性行为的肥大。根据2000年7月5日颁布的德国下萨克森州危险动物法案(GefTVO)的指导方针对该品种的狗进行了测试。将斗牛犬对人类和环境的测试结果与受立法影响的415只狗(Mittmann, 2002)和70只金毛寻回犬(Johann, 2004)的测试结果进行比较,以发现不充分或干扰的攻击行为发生的可能差异。在38只斗牛犬中,有10只对人类和环境没有任何攻击性行为。最多27只狗表现出视觉或听觉威胁。只有一只狗的反应是“咬或攻击之前的威胁行为”。因此,根据测试指南,37只狗(97.37%)在所有测试情况下都做出了适当的反应。只有一只狗(2.63%)表现出不充分的攻击行为。没有迹象表明不充分或不安的攻击行为在这个牛头犬血统被发现。此外,当比较其他两项研究中的斗牛犬和狗对人类和环境的攻击性不足或受到干扰时,没有发现显着差异。相反,在整个研究过程中,绝大多数狗被证明具有出色的社交技能,以及有效沟通和适当解决冲突的能力。
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引用次数: 0
["In the Third Reich there must be no cruelty to animals anymore"--the development of the Reich's Animal Welfare Law from 1933]. [“在第三帝国绝不能再虐待动物”——1933年帝国动物福利法的发展]。
Michael Schimanski

In the German Reich cruelty to animals was punishable over decades only under anthropozentrical points of view, animal experiments and slaughter without stunning were also settled insufficient. Then at the end of the republic of Weimar initiated by the national socialists slaughter without stunning was forbidden. After the takeover by the national socialists the ban was immediately extended to the hole country, the criminal punishment of cruelty to animals was increased and finally the Reichstierschutzgesetz was enacted--influenced by an ethical way of protection of animals. The societies for the prevention of cruelty to animals were aligned and offences against the law were punished with hard sentences. Protection of animals was particularly promoted by the national socialists on propagandistic purposes and served for the compensation of an increasing degeneration of social values.

在德意志帝国,虐待动物几十年来一直受到惩罚,只有在人类中心主义的观点下,动物实验和不打晕的屠杀也没有得到充分解决。在魏玛共和国末期由国家社会主义者发起的屠杀是被禁止的。在国家社会主义者接管后,禁令立即扩展到整个国家,对虐待动物的刑事惩罚增加了,最后颁布了《国家动物保护条例》——受到保护动物的道德方式的影响。防止虐待动物的协会联合起来,违法行为受到严厉的惩罚。国家社会主义者出于宣传目的特别提倡保护动物,并以此作为对日益退化的社会价值的补偿。
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引用次数: 0
Pulmonary aspergillosis in an African elephant (Loxodonta africana). 非洲象肺曲霉病(Loxodonta africana)。
Ute Kaim, Vanja Paltian, Christiane Krudewig, Anne Nieder, Peter Wohlsein

A 26-year-old female African elephant (Loxodonta africana) with a history of purulent pododermatitis, recurrent abdominal pain, and severe weight loss died spontaneously after a period of deteriorating disease. The main pathological finding was a severe bilateral pyogranulomatous, partially necrotizing pneumonia with numerous intralesional fungal hyphae. At microbiological examination Aspergillus spp. were isolated. The present case indicates that mycotic pneumonia should to be considered as a differential diagnosis of pulmonary disorders in elephants.

一只26岁的雌性非洲象(Loxodonta africana)患有化脓性足皮炎、反复腹痛和严重体重减轻病史,在病情恶化一段时间后自然死亡。主要病理表现为严重的双侧脓肉芽肿性部分坏死性肺炎,病灶内有大量真菌菌丝。微生物学检查分离出曲霉属。本病例表明,真菌性肺炎应被视为大象肺部疾病的鉴别诊断。
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引用次数: 0
[Mass culling in the context of animal disease outbreaks--veterinarians caught between ethical issues and control policies]. [动物疾病爆发背景下的大规模扑杀——兽医在伦理问题和控制政策之间进退两难]。
Sonja Hartnack, Marcus G Doherr, Herwig Grimm, Peter Kunzmann

In recent years controversial discussions arose during major animal disease outbreaks in the EU about the ethical soundness of mass culling. In contrast to numerous publications about ethical issues and laboratory animals/animal experiments, literature concerning ethical deliberations in the case of mass culling as a means of outbreak control remain scarce. Veterinarians in charge of decision about and implementation of mass culling actions find themselves in an area of conflict in between the officially required animal disease control policy and a public that is increasingly critical. Those veterinarians are faced with the challenge to defend the relevant decisions against all stakeholders and also themselves. In this context an interdisciplinary workshop was initiated in Switzerland in October 2007 with ethicians and (official) veterinarians from Germany, Switzerland and Austria. With the aim to identify ethical components of animal disease control for official veterinarians, talks and moderated group discussions took place. This article summarizes selected discussion points and conclusions.

近年来,在欧盟爆发重大动物疾病期间,关于大规模扑杀的伦理合理性的争议性讨论出现了。与关于伦理问题和实验室动物/动物实验的众多出版物相比,关于大规模扑杀作为控制疫情手段的伦理审议的文献仍然很少。负责决定和实施大规模扑杀行动的兽医发现自己处于官方要求的动物疾病控制政策与日益重要的公众之间的冲突中。这些兽医面临着对所有利益相关者和他们自己捍卫相关决定的挑战。在此背景下,2007年10月在瑞士发起了一个跨学科研讨会,与会者包括来自德国、瑞士和奥地利的伦理学家和(官方)兽医。为了确定官方兽医控制动物疾病的伦理因素,举行了会谈和主持小组讨论。本文总结了选定的讨论点和结论。
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引用次数: 0
Determination of IgG and IgM levels in sera of newborn calves until the 10th day of life by ELISA and description of their correlation to total plasma protein concentration and GGT activity. ELISA法测定新生犊牛10天前血清IgG和IgM水平及其与血浆总蛋白浓度和GGT活性的相关性
Petra Bender, Hartwig Bostedt

The aim of this study was the determination of IgG and IgM concentrations in sera of 15 vital and healthy calves from the day of birth to the 10th day of life using two ELISAs exclusively developed for this purpose. We investigated if and to which extent the sera profiles were correlated with antibody levels in the colostral milk administered, with GGT activity and with total plasma protein content. Due to the assays' high sensitivity, traces of IgG and IgM in calf sera could be determined prior to the first uptake of the foremilk. Throughout the colostrum administration period until the 12th living hour, IgG and IgM levels remarkably increased (P < 0.0001).The correlation between IgG concentrations in sera determined 24 h post natum and the IgG content of the colostrum administered was highly significant (P < 0.001; r = 0.851), while the correlation of seral IgM levels 24 h post natum and the IgM content of the foremilk was significant (P = 0.009; r = 0.651). The sum of the IgG and IgM concentrations in calf serum 24 h post natum was significantly correlated with the neonatal plasma protein level (P = 0.01; r = 0.642). With P = 0.012; r = 0.629 and P = 0.029; r = 0.561 respectively, there was also a significant correlation between the subjects' IgG and IgM concentrations at 24 h post natum and the GGT activity in calf serum. By looking at individual cases, it became evident that the administration of colostrum containing maximum or minimum immunoglobulin concentrations does not necessarily result in the respective sera immunoglobulin concentrations. From these findings, as well as from the fact that numerous subjects displayed their highest IgG and IgM sera concentrations well after the gut closure, we conclude that individually diverse resorption patterns are in place which cannot be characterized by immunoglobulin measurements only. The determination of the total plasma protein content or GGT activity in calf serum at 24 h post natum only give a rough idea about the actual immunoglobulin supply of the calves, since for the individual subject no conclusion could be drawn to the extent of immunoglobulin concentrations.

本研究的目的是使用专门为此目的开发的两种elisa法测定15头从出生之日至出生第10天的健康犊牛血清中IgG和IgM的浓度。我们研究了血清谱是否以及在多大程度上与所给初乳中的抗体水平、GGT活性和总血浆蛋白含量相关。由于检测的高灵敏度,微量IgG和IgM在犊牛血清中可以确定在第一次摄取前乳之前。在初乳给药期间至第12活小时,IgG和IgM水平显著升高(P < 0.0001)。天然后24 h血清IgG浓度与初乳IgG含量的相关性极显著(P < 0.001;r = 0.851),而24 h后几种IgM水平与前乳IgM含量的相关性显著(P = 0.009;R = 0.651)。犊牛血清中IgG和IgM浓度之和与新生儿血浆蛋白水平极显著相关(P = 0.01;R = 0.642)。P = 0.012;r = 0.629, P = 0.029;r = 0.561,受试者天然后24 h IgG和IgM浓度与犊牛血清GGT活性也有显著相关性。通过观察个别病例,很明显,给予含有最高或最低免疫球蛋白浓度的初乳并不一定会导致各自的血清免疫球蛋白浓度。根据这些发现,以及许多受试者在肠闭合后表现出最高的IgG和IgM血清浓度的事实,我们得出结论,个体不同的吸收模式是存在的,不能仅通过免疫球蛋白测量来表征。测定犊牛天然后24 h血浆总蛋白含量或血清GGT活性只能粗略了解犊牛的实际免疫球蛋白供应情况,因为对个体受试者而言,无法得出免疫球蛋白浓度的结论。
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引用次数: 0
[Fasciolosis in European hares (Lepus europaeus) in North-Western Germany]. [德国西北部欧洲兔(Lepus europaeus)的片形吸虫病]。
Susanne Ziege, Maria Brauneis, Michael von Keyserling, Peter Wohlsein

In this case report pathomorphological findings of acute and chronic stages of fasciolosis are described in a European hare (Lepus europaeus) hunted in NorthWestern Germany. Acute hepatic lesions consisted of coagulation necrosis with haemorrhages and surrounding infiltrations of granulocytes and histiocytes. Subacute to chronic changes were characterized predominantly by pyogranulomatous inflammations with extensive fibrosis. Adult parasites and eggs were detectable.

在本病例中,报告了在德国西北部捕获的一只欧洲野兔(Lepus europaeus)急性和慢性期片膜虫病的病理形态学发现。急性肝脏病变包括凝血坏死伴出血和周围粒细胞和组织细胞浸润。亚急性到慢性变化的特征主要是化脓性肉芽肿性炎症伴广泛纤维化。检测到成虫和虫卵。
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引用次数: 0
[Congenital hydrocephalus internus of the dog: clinical, computed tomographic and pathomorphological features of six cases]. [犬先天性脑积水:6例临床、ct及病理形态学特征]。
C Brüssau, A Meyer-Lindenberg, P Wohlsein, I Nolte

The present study rates the value of different investigative procedures used to diagnose a congenital hydrocephalus internus of the dog. Six dogs, aged between two and ten months, were presented in our clinic with neurologic signs because of a congenital hydrocephalus internus. After taking a neurologic examination and further diagnostic studies they were euthanized and dissected. The neurologic examination did not help to predict the exact location of the lesion in the brain. Very high amplitudes and low frequencies are the characteristic electroencephalographic pattern of congenital hydrocephalus internus; they occurred in all electroencephalograms (EEGs). Radiologic changes like calvarial enlargement or thinning of the bony walls could be seen only in patients whose brain volumes had increased before the closure of the cranial sutures. The CT images of all dogs showed the dilatations of the cerebral ventricles in their entire size. Examination of the cerebrospinal fluid did not yield uniform findings. Consequently, EEG, conventional diagnostic radiography and computed tomography of the skull are the most important studies for diagnosing a primary hydrocephalus internus. However, the total extent of the lesion can be confirmed only by computed tomography. This is of special interest in case of planning and controlling therapies.

目前的研究率的价值不同的调查程序用于诊断先天性脑积水的狗。6只狗,年龄在2到10个月之间,由于先天性内脑积水而出现神经系统症状。在接受了神经学检查和进一步的诊断研究后,他们被安乐死并被解剖。神经学检查并不能帮助预测病变在大脑中的确切位置。高振幅和低频率是先天性内脑积水的特征性脑电图模式;所有脑电图均可见。影像学改变,如颅骨增大或骨壁变薄,只能在颅缝闭合前脑容量增加的患者中看到。所有犬的CT图像均显示脑室整体扩张。脑脊液检查结果不一致。因此,脑电图、常规放射诊断和颅骨计算机断层扫描是诊断原发性内脑积水最重要的研究。然而,病变的总范围只能通过计算机断层扫描来确定。这在计划和控制治疗的情况下是特别有趣的。
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引用次数: 0
The effect of glucose treatment on ruminal dry matter and crude protein degradability characteristics of soybean meal, full fat soybean and soybean seed. 葡萄糖处理对豆粕、全脂大豆和大豆籽粒瘤胃干物质和粗蛋白降解特性的影响
Pinar Sacakli, Sakir Doğan Tuncer, Bekir Hakan Koksal, Zehra Selcuk, Kadir Emre Bugdayci

A high ruminal protein degradation is especially undesirable in high producing dairy cows and beef cattle, since these animals have high requirements of protein and the amount of protein that is not degraded by ruminal microorganisms and therefore enters the small intestine (so-called UDP = undegraded protein) is crucial. In this study, Merino rams with ruminal fistulas were used (n = 4) to determine the effect of glucose treatment of soybean meal (SBM), full fat soybean (FFSB) and soybean seed (SBS) on the ruminal degradability of dry matter (DM) and crude protein (CP). All these feedstuffs were grinded, diluted with water and heated (2 h; 100 degrees C) either without or with supplementation of 2 or 3% glucose (20 or 30 g glucose per kg dry feed). For the determination of the ruminal degradability nylon bag technique was used (incubation times: 2-48 h). In general ruminal degradability of protein in all three soy products was reduced by glucose treatment. In FFSB CP disappearance started to decrease after 8 h of incubation, whereas in SBM (+ 3% glucose) and SBS (+ 2 or 3% glucose) reduction of CP disappearance were time-independent. Further, effective degradability (Pe) of DM and CP of all feedstuffs were significantly reduced by glucose treatment, with the reduction being more pronounced when the glucose level was increased. When adding 3% of glucose, the Pe for CP was reduced by 6 (FFSB), 16 (SBM) and 18% (SBS), respectively. Explanation for the observed effects of a glucose supplementation (incl. water and heat treatment) is the reductive activity of glucose within these conditions.

对于高产奶牛和肉牛来说,瘤胃蛋白质的高降解率尤其不可取,因为这些动物对蛋白质的需求量很高,而未被瘤胃微生物降解并因此进入小肠的蛋白质量(即所谓的 UDP = 未降解蛋白质)至关重要。本研究使用患有瘤胃瘘管的美利奴公羊(n = 4)来测定葡萄糖处理豆粕(SBM)、全脂大豆(FFSB)和大豆种子(SBS)对干物质(DM)和粗蛋白(CP)的瘤胃降解性的影响。将所有这些饲料磨碎,加水稀释并加热(2 小时;100 摄氏度),不添加或添加 2% 或 3% 葡萄糖(每公斤干饲料添加 20 或 30 克葡萄糖)。瘤胃降解性的测定采用尼龙袋技术(培养时间:2-48 小时)。总的来说,葡萄糖处理降低了三种豆制品中蛋白质的瘤胃降解性。在 FFSB 中,CP 消失率在培养 8 小时后开始下降,而在 SBM(+ 3% 葡萄糖)和 SBS(+ 2 或 3% 葡萄糖)中,CP 消失率的下降与时间无关。此外,葡萄糖处理显著降低了所有饲料的 DM 和 CP 的有效降解率(Pe),当葡萄糖含量增加时,降解率的降低更为明显。当添加 3% 的葡萄糖时,CP 的有效降解率分别降低了 6%(FFSB)、16%(SBM)和 18%(SBS)。葡萄糖补充剂(包括水和热处理)所产生的效果可以解释为葡萄糖在这些条件下的还原活性。
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引用次数: 0
期刊
Dtw. Deutsche Tierärztliche Wochenschrift
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