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Analysis of emergency department waiting lines 急诊科排队情况分析
Q4 Medicine Pub Date : 2014-10-01 DOI: 10.6016/SLOVMEDJOUR.V83I9.1279
Urška Močnik, M. Gradisar, Luka Tomat
Background : Steady increase in the numbers of patients seeking medical assistance has recently been observed at the emergency department of the health center under study. This has led to increases in waiting times for patients. The management of the health center has been considering to implement certain measures to remedy this situation. One proposed solution is to add an additional physician to the emergency department. A computer model was constructed to simulate waiting lines and analyze the economic feasibility of employing an additional physician. Aim : This paper analyzes the waiting lines at the emergency department and performs an economic feasibility study to determine whether adding an additional physician to the department would be economically justified. Methods : Data about waiting times at the emergency department were collected to study the situation. For each patient, the arrival time at the waiting room and the starting and ending times of the examination were registered. The data were collected from 13 June 2011 to 25 September 2011. The sample included data on 65 nightly standbys, nine standbys on Saturdays, and 16 standbys on Sundays. Due to incomplete entries, data for nine weekly standbys and six Saturday standbys were excluded from the sample. Based on the data collected, we calculated the waiting and examination times per patient, average number of patients, average waiting time, average examination time, share of active standby teams in total standby time, and number of patients in different time periods. The study involved 1,039 patients. Using a synthesis method, we designed a computer model of waiting lines and economic feasibility. The model was validated using comparative analysis. A what-if analysis was performed using various computer simulations with various scenarios to consider the outcomes of decision alternatives. We applied economic analysis to select the best possible solution. Results : The research results show that emergency department teams face overcrowding at certain periods. This is particularly challenging for employees performing 24-hour standbys, when they are working at the limit of their capacity. The results show that the total cost of waiting lines with two physicians is higher in all cases. The introduction of an additional channel or employing an additional physician increases the total cost by 35 to 50 %. Employing an additional physician is therefore not economically justified. Conclusion : This study showed how a computer model can be used to improve the information basis for decision-making in healthcare organization management. Based on quantitative data obtained by using a model with alternative scenarios, we developed an economic analysis of alternatives and made a decision. The cost analysis of potentially employing an additional physician showed that the cost would exceed the benefits obtained in all scenarios analyzed. The proposed decision-support method can be implemented at a v
背景:最近在研究中的卫生中心急诊科观察到寻求医疗援助的患者数量稳步增加。这导致了患者等待时间的增加。保健中心的管理部门一直在考虑采取某些措施来纠正这种情况。一个建议的解决方案是在急诊科增加一名额外的医生。建立了一个计算机模型来模拟排队等候,并分析雇用额外医生的经济可行性。目的:本文分析了急诊科的排队情况,并进行了经济可行性研究,以确定在急诊科增加一名额外的医生是否在经济上是合理的。方法:收集急诊科候诊时间的相关数据进行调查。记录每位患者到达候诊室的时间以及检查的开始和结束时间。数据收集于2011年6月13日至2011年9月25日。样本包括65个夜间备用、9个周六备用和16个周日备用的数据。由于条目不完整,9个每周备用数据和6个周六备用数据被排除在样本之外。根据收集到的数据,我们计算了每个患者的等待和检查次数,平均患者人数,平均等待时间,平均检查时间,活跃备用团队占总备用时间的份额,以及不同时间段的患者人数。这项研究涉及1039名患者。采用综合分析的方法,设计了排队等候的计算机模型和经济可行性。通过对比分析对模型进行了验证。使用各种计算机模拟和各种场景进行了假设分析,以考虑决策备选方案的结果。我们运用经济分析来选择可能的最佳解决方案。结果:研究结果表明,急诊科队伍在一定时期面临人满为患的问题。这对24小时待命的员工来说尤其具有挑战性,因为他们的工作能力已经到了极限。结果表明,在所有情况下,两名医生排队等候的总成本都更高。引入额外的渠道或雇用额外的医生会使总成本增加35%至50%。因此,雇用额外的医生在经济上是不合理的。结论:利用计算机模型提高医疗机构管理决策的信息基础。基于使用备选方案模型获得的定量数据,我们对备选方案进行了经济分析并做出了决策。潜在的额外雇用一名医生的成本分析表明,在所有分析的情况下,成本将超过所获得的收益。所提出的决策支持方法可以在处理类似问题的所有医疗保健组织中以非常低的成本实现。
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引用次数: 1
Point-of-care lactate testing in emergency room. 急诊室即时乳酸检测
Q4 Medicine Pub Date : 2014-04-01 DOI: 10.6016/SLOVMEDJOUR.V83I3.1139
Darinka Purg, A. Markota, Matej Berhardt
Lactate is a product of anaerobic metabolism, which can be used to detect the critically ill. Rapid recognition, early appropriate treatment and control of treatment success are paramount in that population. Lactate levels need to be available as soon as possible if they are to be of assistance at the bedside. Point-of-care analyzers enable rapid determination of lactate. The role of point-of-care lactate analyzers in the treatment of the critically ill, different analysis techniques and limitations of point-of-care lactate analyzers are presented. The use of point-of-care lactate analyzers is demonstrated in two cases of patients with sepsis. The first patient is a 73-year-old female, where point-of-care lactate was determined immediately. Septic shock with multi-organ failure developed. She was successfully treated and discharged after 14 days to home care. The second patient is a 62-year old male, where elevated lactate was detected after three hours. The patient died after a total of 5 months of treatment in the intensive care unit. Lactate can be an important tool in early recognition and treatment of the critically ill.
乳酸是无氧代谢的产物,可用于危重病人的检测。在这一人群中,快速识别、早期适当治疗和控制治疗成功至关重要。乳酸水平需要尽快得到,如果他们是在床边的帮助。即时分析仪能够快速测定乳酸。点护理乳酸分析仪的作用在治疗危重病人,不同的分析技术和点护理乳酸分析仪的局限性提出。使用点护理乳酸分析仪证明了两个病例的患者败血症。第一位患者为一名73岁女性,立即测定了其护理点乳酸水平。脓毒性休克并发多器官衰竭。她得到了成功的治疗,并在14天后出院,接受了家庭护理。第二例患者为62岁男性,3小时后检测到乳酸水平升高。患者在重症监护室治疗5个月后死亡。乳酸盐可以作为早期识别和治疗危重症的重要工具。
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引用次数: 0
The impact of office workspace on the satisfaction of employees and their overall health - research presentation. 办公室工作环境对员工满意度和整体健康的影响——研究报告。
Q4 Medicine Pub Date : 2014-04-01 DOI: 10.6016/SLOVMEDJOUR.V83I3.1134
Andrej Baričič, A. T. Salaj
Background : The present article addresses the links between the real-estate factors of the workspace on employee satisfaction and their impact on the overall health of employees. The purpose of the research is to facilitate the improvement of employee health through the application of base parameters, and consequently, the changes of workspace and work processes. The research tests two hypotheses: real-estate factors have a significant impact on employee satisfaction with the workspace; and that satisfaction of employees with the workspace has a significant impact on the overall health of employees. Methodology : We carried out a quantitative research with a broad range of different questions, scales and differentials, whereby the majority of instruments was originally constructed with suitable measurement characteristics. Testing of the questionnaire with the method of internal consistency showed that the questionnaire demonstrates a high level of consistency. The entire questionnaire includes 163 variables divided into content sections: general questions, business building and workspace, workspace design, habits, conditions in the workspace, organisational culture, health care, physical health condition, mental health condition. In July and August 2010, the questionnaire was completed by 1,036 employees from entities in the service sector, i.e. the financial sector, health sector, civil service and others. All the respondents included in the research sample worked in offices. The questionnaire was anonymous in accordance with ethical standards. The results were statistically analysed with the application of factor analysis, which served as a basis for identifying the important factors, while we applied structural equation modelling for verifying the statistically significant mutual effects. Furthermore, we analysed the results and carried out statistical calculations to test the hypotheses. Results : The results show that real-estate factors of the workspace – both in terms of the assessment of business building and position of the employee, as well as the workspace design – have an impact on the satisfaction of employees, and consequently, their assessment of health. On the basis of solutions of structural equation modelling, we established that: the cleanliness of the workspace, lighting of the workspace, orientation of the workspace, regulation of lighting and regulation of air-conditioning in the premises, have a statistically significant impact on the satisfaction of employees with the workspace. With the aid of factor analysis and analysis of the structural equation modelling, as well as in accordance with the set hypotheses, we tested whether the ‘employment satisfaction’ factor affects the ‘overall health’ factor. We established a significant negative link between these two factors. Conclusions : We established a statistically significant impact of real-estate factors of the workspace on the satisfaction of employees, and consequently,
背景:本文讨论了工作空间的房地产因素对员工满意度及其对员工整体健康的影响之间的联系。研究的目的是通过基本参数的应用,促进员工健康的改善,从而改变工作空间和工作流程。该研究检验了两个假设:房地产因素对员工对工作空间的满意度有显著影响;员工对工作空间的满意度对员工的整体健康有重大影响。方法:我们进行了一项定量研究,涉及范围广泛的不同问题、尺度和微分,其中大多数仪器最初都具有合适的测量特性。用内部一致性法对问卷进行检验,结果表明问卷具有较高的一致性。整个问卷包括163个变量,分为内容部分:一般问题、业务建设和工作空间、工作空间设计、习惯、工作空间条件、组织文化、卫生保健、身体健康状况、心理健康状况。2010年7月和8月,来自服务部门实体(即金融部门、卫生部门、公务员制度和其他部门)的1 036名雇员完成了调查表。研究样本中的所有受访者都在办公室工作。根据道德标准,问卷是匿名的。应用因子分析对结果进行统计分析,作为识别重要因素的基础,并应用结构方程模型对统计显著的相互效应进行验证。此外,我们对结果进行了分析,并进行了统计计算来检验假设。结果:结果表明,工作空间的房地产因素——无论是对员工的业务建筑和职位的评估,还是工作空间的设计——都会影响员工的满意度,从而影响他们对健康的评估。在结构方程模型解的基础上,我们建立了:工作空间的清洁度,工作空间的照明,工作空间的朝向,照明的调节和场所空调的调节,对员工对工作空间的满意度有统计学上显著的影响。借助因子分析和结构方程模型分析,并根据设定的假设,检验了“就业满意度”因素是否影响“整体健康”因素。我们在这两个因素之间建立了显著的负相关。结论:我们建立了一个统计显著的影响房地产因素的工作空间对员工的满意度,从而评估他们的整体健康。我们强调有必要进一步分析和研究有关因素对雇员健康的影响,并通过在工作环境中对雇员的健康进行预防性和定期测试来监测这些影响。
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引用次数: 12
Enhanced recovery after surgery in patients with colorectal cancer in Slovenia 2012 2012年斯洛文尼亚大肠癌患者手术后恢复增强
Q4 Medicine Pub Date : 2014-03-01 DOI: 10.6016/SLOVMEDJOUR.V83I2.1097
M. Rems, Vlado Jurekovič, Polona Studen Pauletič
Background : Enhanced recovery after surgery (ERAS) protocol is a model of perioperative patient management where process optimisation helps to shorten patients’ recovery time. Application of ERAS protocol in colorectal cancer surgery is a demanding process, challenging our professional and organisational measures. Methods : A questionnaire regarding ERAS was sent to all thirteen heads of departments performing surgical treatment of colorectal cancer patients in Slovenia. The questionnaire was analyzed using Microsoft Excel Program. Results : There is a strong agreement among all the respondents that ERAS is a relevant clinical concept. Only seven clinical departments have developed a clinical pathway consistent with ERAS protocol, but principles of ERAS are followed at least partly or completely in twelve clinical departments. The most obvious is lack of activity before surgery, and particularly the educational interview with a dietitian and a physiotherapist. Less than half of the patients drink the glucose drink before surgery, and the same applies to the prophylaxis of nausea and vomiting. More than two thirds of patients are still subjected to mechanical bowel preparation before surgery. More than half of them have a central line and are admitted to intensive care unit (ICU) after surgery. More than 75 % of the patients do not sit up in bed or stand up on day 1 after surgery. More than half of them still have the nasogastric tube. Laparoscopy is used more frequently for colon and less for rectal surgery. Conclusions : Comparing this analysis with the one done in 2004, we can conclude that there is an important shortening of average planned hospital stay. Nevertheless, still the majority of patients are not managed according to the ERAS protocol. The implementation of ERAS concept in Slovenia is rather poor, contrary to what we would expect considering evidence-based positive effects, but nevertheless comparable to other’s experience.
背景:ERAS方案是围手术期患者管理的一种模式,其中流程优化有助于缩短患者的恢复时间。ERAS方案在结直肠癌手术中的应用是一个要求很高的过程,对我们的专业和组织措施提出了挑战。方法:向斯洛文尼亚所有13位大肠癌患者外科治疗部门的负责人发送关于ERAS的调查问卷。使用Microsoft Excel程序对问卷进行分析。结果:所有受访者都强烈认同ERAS是一个相关的临床概念。只有7个临床科室制定了符合ERAS方案的临床路径,但至少有12个临床科室部分或完全遵循ERAS原则。最明显的是手术前缺乏活动,特别是与营养师和物理治疗师的教育访谈。不到一半的患者在手术前饮用葡萄糖饮料,同样适用于预防恶心和呕吐。超过三分之二的患者在手术前仍需进行机械肠道准备。其中一半以上的患者有中心静脉导管,并在手术后入住重症监护病房(ICU)。超过75%的患者术后第一天不能在床上坐起来或站起来。超过一半的人仍然使用鼻胃管。腹腔镜更常用于结肠手术,而较少用于直肠手术。结论:与2004年的分析比较,我们可以得出平均计划住院时间明显缩短的结论。尽管如此,大多数患者仍未按照ERAS方案进行管理。在斯洛文尼亚,ERAS概念的执行情况相当差,与我们所期望的相反,考虑到基于证据的积极影响,但与其他国家的经验相当。
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引用次数: 2
Chronic ischemic mitral regurgitation - a diagnostic and therapeutic challenge. 慢性缺血性二尖瓣反流-诊断和治疗的挑战。
Q4 Medicine Pub Date : 2014-01-01 DOI: 10.6016/SLOVMEDJOUR.V83I1.1078
J. Ambrožič, J. Toplišek, Ivana Knežević, M. Bunc, D. Stajer
Izvlecek Kronicna ishemicna mitralna regurgitacija (IMR) je napaka mitralne zaklopke, ki je posledica primarne okvare levega prekata zaradi koronarne bolezni. Nastane zaradi okvare krcenja in/ali preoblikovanja levega prekata, ki posredno onemogocata pravilno zapiranje mitralne zaklopke. Kronicna IMR ni posledica spremembe strukture mitralne zaklopke, prav tako ne stejemo za IMR akutne mitralne regurgitacije po infarktu. Kronicna IMR nastane v kronicnem obdobju srcnega infarkta pri okoli 20–50 % bolnikov, njena prevalenca v populaciji narasca. Prisotnost IMR je poleg oslabelega krcenja levega prekata najpomembnejsi negativen napovedni znak za preživetje po srcnem infarktu. Prognosticno je pomembna že regurgitacija, ki bi jo pri organski bolezni mitralne zaklopke steli za blago.
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引用次数: 3
Usefulness of the patient information leaflet (PIL) and information on medicines from professionals: A patients’ view. A qualitative study 患者信息单张(PIL)和专业人员提供的药物信息的有用性:患者的观点。定性研究
Q4 Medicine Pub Date : 2014-01-01 DOI: 10.6016/SLOVMEDJOUR.V83I5.1213
Tonka Poplas-Susič, Z. Klemenc-Ketiš, J. Kersnik
Background : The Patient information leaflet (PIL) is an important source of information for every patient. Little is known about whether patients read the PIL and whether it contains useful information. Other sources of drug-related information are professionals (a family practitioner, a pharmacist and a nurse). Informing patients on drugs improves their compliance. The aim of the study was to identify the usefulness of PIL from the perspective of the patient, to assess professionals as a source of drug-related information and to suggest changes that can improve informing and therefore patients’ compliances. Methods : Four focus group interviews were conducted across different primary health care centres in the North East of Slovenia. Focus groups were composed of randomly selected patients (in total 20) who were willing to express their views on PILs, on other drug information sources and on possible improvements. A qualitative analysis of the data was based of the transcription of the audiotapes. Results : Patients read the PILs selectively. They were most interested in side effects, contraindications and the purpose of the prescribed drug. Participants reported that the language in PILs is too scientific. In the case they do not understand PILs or they recognise some of the side effects, a majority of participants decide to contact a family physician first, and less frequently a pharmacist or a nurse. A family physician is considered to be the most trustworthy source of information and patients think that pharmacists could play a more active role in patients’ education. Conclusion : Current PILs offer enough partial information to patients but need some improvements in terms of better legibility and access to the most crucial information. PIL does not enable a comprehensive information with respect to patient’s health status. Most reliable source of information is considered to be a family practitioner. Pharmacists could play a more active role in the education of patients.
背景:患者信息单张(PIL)是每个患者的重要信息来源。对于患者是否阅读PIL以及它是否包含有用的信息,人们知之甚少。药物相关信息的其他来源是专业人员(家庭医生、药剂师和护士)。告知患者药物信息可以提高他们的依从性。本研究的目的是从患者的角度确定PIL的有用性,评估专业人员作为药物相关信息的来源,并提出可以改善信息的建议,从而提高患者的依从性。方法:在斯洛文尼亚东北部不同的初级卫生保健中心进行了四次焦点小组访谈。焦点小组由随机选择的患者(共20人)组成,这些患者愿意就PILs、其他药物信息来源和可能的改进发表意见。数据的定性分析是基于录音带的转录。结果:患者有选择性地阅读药单。他们最感兴趣的是副作用、禁忌症和处方药的用途。与会者报告说,pil中的语言过于科学。如果他们不了解PILs或他们认识到一些副作用,大多数参与者决定首先联系家庭医生,很少联系药剂师或护士。家庭医生被认为是最值得信赖的信息来源,患者认为药剂师可以在患者教育中发挥更积极的作用。结论:目前的pill为患者提供了足够的部分信息,但在更好的易读性和获取最关键信息方面需要一些改进。PIL不能提供有关患者健康状况的全面信息。最可靠的信息来源被认为是家庭医生。药师可以在对患者的教育中发挥更积极的作用。
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引用次数: 10
Infant with fever and cochlear implant. 婴儿发烧并植入人工耳蜗。
Q4 Medicine Pub Date : 2014-01-01 DOI: 10.6016/SLOVMEDJOUR.V83I2.1110
M. Arnež, A. Gros
The article provides recommendations for evaluation and treatment of children with cochlear implants. An illustrative case of an infant with Haemophylus influenzae type e bacterial meningitis eighteen days following cochlear implant placement is reported. Indications for implantation and criteria to be fulfilled before implantation of cochlear implants are described. The importance of appropriate vaccination of children with cochlear implants as well as treatment of both acute otitis media and bacterial meningitis in these children is stressed.
本文提供了评估和治疗儿童人工耳蜗的建议。一个说明性的情况下,婴儿与流感嗜血杆菌e型细菌性脑膜炎18天后,耳蜗植入报告。介绍了人工耳蜗植入术的适应症和植入术前应满足的标准。强调了对植入人工耳蜗的儿童进行适当疫苗接种以及对这些儿童进行急性中耳炎和细菌性脑膜炎治疗的重要性。
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引用次数: 0
Impact of systemic diseases on oral health related quality of life after implant-prosthodontic rehabilitation. 种植修复康复后全身性疾病对口腔健康相关生活质量的影响。
Q4 Medicine Pub Date : 2014-01-01 DOI: 10.6016/SLOVMEDJOUR.V83I6.1243
Tina Pretnar, N. Hren, K. Rener-Sitar
Background : Implant-prosthodontic rehabilitation improves oral health related quality of life (OHRQoL), but the presence of systemic diseases can also affect the well-being of an individual. The study was carried out to determine the relationship between systemic diseases and OHRQoL after implant-prosthodontic rehabilitation on the basis of psychometric testing by a standardized questionnaire »Oral Health Impact Profile« (OHIP). Methods : 130 patients, who received one to eight Ankylos® implants (on average 2.6 ± 1.8) were included in this retrospective study in which all aspects of the OHRQoL construct were evaluated with a Slovenian version of the OHIP questionnaire. Data on all present systemic diseases were obtained from the existing health records. Dental status and dental restorations were identified on the basis of orthopantomographic images. Results: The majority of subjects had a cardiovascular disease (N = 37; 28.5 %), followed by a headache (N = 15, 11.5 %), allergies and asthma (n = 13, 10 %), and a rheumatic disease (N = 11, 8.5 %). Only osteoporosis was statistically significantly related to OHRQoL after implant-prosthodontic rehabilitation (p = 0.024). The best multiple linear regression model for the summary score for the questionnaire »Oral Health Impact Profile« for Slovenia (OHIP), and taking into account gender and age as confounding factors, included the number of remaining teeth and the presence of osteoporosis (p = 0.003, adjusted R2 = 0.104). Conclusions : The total number of remaining teeth in the oral cavity (p = 0.031), the presence of osteoporosis (p = 0.024), and taking into account the subject’s gender and age, are the most important clinical factors that affect the functioning of the SGS as well as psychosocial behavior of the patients after an implant-prosthodontic rehabilitation (adjusted R2 = 0.104). Other systemic diseases (cardiovascular disease, headache, allergies and asthma, rheumatic disease, obesity, gastritis, diabetes, thyroid disease) did not statistically significantly correlate with the OHRQoL concept.
背景:种植修复可以改善口腔健康相关的生活质量(OHRQoL),但全身性疾病的存在也会影响个体的健康。本研究通过标准化问卷“口腔健康影响档案”(OHIP)进行心理测量测试,以确定种植-修复康复后全身性疾病与OHRQoL之间的关系。方法:本回顾性研究纳入130例接受1至8个Ankylos®植入物(平均2.6±1.8)的患者,使用斯洛文尼亚版的OHIP问卷对OHRQoL结构的各个方面进行评估。所有现有全身性疾病的数据均来自现有的健康记录。牙体状态和牙体修复是在骨断层成像的基础上确定的。结果:大多数受试者存在心血管疾病(N = 37;28.5%),其次是头痛(N = 15, 11.5%)、过敏和哮喘(N = 13, 10%)以及风湿病(N = 11, 8.5%)。只有骨质疏松症与种植修复后OHRQoL有统计学意义(p = 0.024)。考虑到性别和年龄作为混杂因素,斯洛文尼亚(OHIP)问卷“口腔健康影响资料”总结得分的最佳多元线性回归模型包括剩余牙齿的数量和骨质疏松的存在(p = 0.003,调整后的R2 = 0.104)。结论:口腔剩余牙齿总数(p = 0.031)、骨质疏松(p = 0.024)、考虑受试者性别和年龄是影响患者种植-修复康复后SGS功能和心理社会行为的最重要临床因素(调整R2 = 0.104)。其他全身性疾病(心血管疾病、头痛、过敏和哮喘、风湿病、肥胖、胃炎、糖尿病、甲状腺疾病)与OHRQoL概念无统计学显著相关。
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引用次数: 1
Generalised anxiety disorder 广泛性焦虑症
Q4 Medicine Pub Date : 2013-09-01 DOI: 10.6016/SLOVMEDJOUR.V82I9.680
Bojana Avguštin Avčin, Nina Konečnik
Generalised anxiety disorder is characterised by persistent, excessive and difficult-to-control worry, which may be accompanied by several psychic and somatic symptoms, including suicidality. Generalized anxiety disorder is the most common psychiatric disorder in the primary care, although it is often underrecognised and undertreated. Generalized anxiety disorder is typically a chronic condition with low short- and medium-term remission rates. Clinical presentations often include depression, somatic illness, pain, fatigue and problems sleeping. The evaluation of prognosis is complicated by frequent comorbidity with other anxiety disorders and depression, which worsen the long-term outcome and accompanying burden of disability. The two main treatments for generalised anxiety disorder are medications and psychotherapy. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors represent first-line psychopharmacologic treatment for generalised anxiety disorder. The most extensively studied psychotherapy for anxiety is cognitive behavioural therapy which has demonstrated efficacy throughout controlled studies.
广泛性焦虑障碍的特征是持续的、过度的和难以控制的担忧,这可能伴随着一些精神和身体症状,包括自杀。广泛性焦虑障碍是初级保健中最常见的精神障碍,尽管它经常被低估和治疗不足。广泛性焦虑障碍是一种典型的慢性疾病,短期和中期缓解率低。临床表现通常包括抑郁、躯体疾病、疼痛、疲劳和睡眠问题。预后评估因经常与其他焦虑症和抑郁症合并症而变得复杂,这使长期预后和伴随的残疾负担恶化。治疗广泛性焦虑症的两种主要方法是药物治疗和心理治疗。选择性5 -羟色胺再摄取抑制剂和5 -羟色胺-去甲肾上腺素再摄取抑制剂是广泛性焦虑症的一线精神药物治疗方法。研究最广泛的焦虑心理疗法是认知行为疗法,在对照研究中已证明其有效性。
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引用次数: 0
Microbiological procedures in the diagnostics of sepsis 诊断败血症的微生物程序
Q4 Medicine Pub Date : 2013-07-01 DOI: 10.6016/SLOVMEDJOUR.V82I7.662
M. M. Premru, B. Beović, V. Špik
Background :Sepsis is one of the most serious bacterial infections. The diagnosis of sepsis is clinical. Microbiologists can detect bacteremia, which however is not present in all septic patients, by the procedure called blood culture. Methods :Blood culture is a semi-automated procedure of culturing blood in liquid media to detect and identify the causative agents. It is important to take 2 to 3 blood cultures with adequate volume of blood. The new, faster methods for bacterial identification from positive blood cultures and molecular methods for the detection of bacterial DNA directly from a blood sample are also becoming available. Results :In the years 2006 to 2011, the number of blood cultures obtained from patients in the University Medical Centre in Ljubljana, Institute of Oncology and the General hospital of Trbovlje (from 2007) was constantly increasing, from 18,404 in 2006 to 25,214 in 2011. The number of patients with positive blood culture/s increased from 1,033 in 2006 to 1,396 in 2011. The rate of blood culture positivity ranged from 10.9 % to 12.3 %. The ratio between gram-positive and gram-negative bacteria was approximately 50:50 %. In all the years under study, Escherichia coliwas the most frequent pathogenic isolate (19.2 % to 22.9 %), followed by Staphylococcus aureus(15.3 % to 17.4 %). Klebsiellaspp. represented 5.3 % to 8.3 % of isolates, Pseudomonas aeruginosa1.8 % to 3.4 %, Streptococcus pneumoniae2.9 % to 4.7 %, Enterococcusspp. 5.4 % to 8.1 %, anaerobes 2.1 % to 3.2 %. Coagulase-negative staphylococci decreased from 23.3 % to 16.9 %. Today, bacteria are identified by the fast and accurate method of mass spectrometry. Bacteria can alternativelly be detected directly from blood by the molecular tests. Conclusions :Blood culture is a very common procedure, its rate of positivity is stable. Among bacteria, the number and the proportion of pathogenic bacteria such as E. coli, S. aureusand S. pneumoniaeis increasing and the proportion of contaminants is decreasing
背景:脓毒症是最严重的细菌感染之一。败血症的诊断是临床的。微生物学家可以通过血液培养的方法检测到菌血症,但并非所有败血症患者都存在菌血症。方法:血液培养是一种在液体培养基中培养血液以检测和鉴定病原体的半自动化过程。重要的是要进行2 - 3次血培养,保证足够的血容量。新的、更快的从阳性血液培养中鉴定细菌的方法和直接从血液样本中检测细菌DNA的分子方法也正在变得可行。结果:2006年至2011年,卢布尔雅那大学医学中心、肿瘤研究所和特博弗列总医院(从2007年开始)从患者身上获得的血液培养数量不断增加,从2006年的18,404例增加到2011年的25,214例。血培养阳性患者从2006年的1033例增加到2011年的1396例。血培养阳性率为10.9% ~ 12.3%。革兰氏阳性菌和革兰氏阴性菌的比例约为50:50 %。在所有研究年份中,大肠杆菌是最常见的致病分离物(19.2%至22.9%),其次是金黄色葡萄球菌(15.3%至17.4%)。Klebsiellaspp。其中铜绿假单胞菌占5.3%至8.3%,肺炎链球菌占2.9%至4.7%,肠球菌占5.4%至8.1%,厌氧菌占2.1%至3.2%。凝固酶阴性葡萄球菌从23.3%下降到16.9%。今天,细菌是通过快速准确的质谱法来鉴定的。细菌也可以通过分子检测直接从血液中检测出来。结论:血培养是一种很常见的方法,其阳性率稳定。细菌中,大肠杆菌、金黄色葡萄球菌、肺炎链球菌等致病菌的数量和比例在增加,污染物的比例在下降
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引用次数: 2
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Zdravniski Vestnik-Slovenian Medical Journal
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