Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-85651
Orhan Göktürk, Onur Avcı, Oğuz Gündoğdu, A. C. Işbir, İclal Özdemir Kol, S. Gürsoy, K. Kaygusuz
ABS TRACT Objective: The aim of this study was to compare the sensitivity and specificity of Pleth Variability Index (PVI) and distensibility of inferior vena cava (dIVC) in fluid responsiveness of patients with sepsis. Material and Methods: Forty patients over 18 years of age who underwent fluid replacement for sepsis in the intensive care unit were included in the study. In our study, the patients were divided into 2 groups as those who had less than 15% increase in cardiac output (CO), and those who had more than 15% increase in CO after fluid replacement (fluid responders and non-responders). Before fluid replacement, demographic data of the patients (age, weight, cause of sepsis, body surface area, SOFA score), vital parameters (systolic arterial pressure, diastolic arterial pressure, mean arterial pressue, heart rate) and measuredd val- ues (maximum diameter of vena cava inferior, minimum diameter of vena cava inferior, central venous pressure, PVI, CO, and stroke volume) were recorded. After applying crystalloid in a dose of 10 mL/kg for 15 minutes, the recorded parameters were repeated at 15 th minute. Results: When receiver operating characteristic (ROC) analysis was performed for dIVC, the area under the curve (AUC) was found to be 0.833 (0.739-0.926). The threshold value was found to be 17.52%, sensitivity was 77.5%, and specificity was 72.5%. When ROC analysis was performed for PVI, AUC was found to be 0.889 (0.817-0.962). The threshold value was found as 12.50%, sensitivity was 72.5%, and specificity was 92.5%. Conclusion: PVI was found to be more specific but less sensitive than dIVC. dIVC is less sensitive and less specific than central venous pressure. However, dIVC and PVI can give useful results in patients who have con- traindication of an invasive technique.
{"title":"Comparison of Pleth Variability Index and Inferior Vena Cava Distensibility as a Perfusion Indicator in Sepsis Patients: An Observational Study","authors":"Orhan Göktürk, Onur Avcı, Oğuz Gündoğdu, A. C. Işbir, İclal Özdemir Kol, S. Gürsoy, K. Kaygusuz","doi":"10.5336/medsci.2021-85651","DOIUrl":"https://doi.org/10.5336/medsci.2021-85651","url":null,"abstract":"ABS TRACT Objective: The aim of this study was to compare the sensitivity and specificity of Pleth Variability Index (PVI) and distensibility of inferior vena cava (dIVC) in fluid responsiveness of patients with sepsis. Material and Methods: Forty patients over 18 years of age who underwent fluid replacement for sepsis in the intensive care unit were included in the study. In our study, the patients were divided into 2 groups as those who had less than 15% increase in cardiac output (CO), and those who had more than 15% increase in CO after fluid replacement (fluid responders and non-responders). Before fluid replacement, demographic data of the patients (age, weight, cause of sepsis, body surface area, SOFA score), vital parameters (systolic arterial pressure, diastolic arterial pressure, mean arterial pressue, heart rate) and measuredd val- ues (maximum diameter of vena cava inferior, minimum diameter of vena cava inferior, central venous pressure, PVI, CO, and stroke volume) were recorded. After applying crystalloid in a dose of 10 mL/kg for 15 minutes, the recorded parameters were repeated at 15 th minute. Results: When receiver operating characteristic (ROC) analysis was performed for dIVC, the area under the curve (AUC) was found to be 0.833 (0.739-0.926). The threshold value was found to be 17.52%, sensitivity was 77.5%, and specificity was 72.5%. When ROC analysis was performed for PVI, AUC was found to be 0.889 (0.817-0.962). The threshold value was found as 12.50%, sensitivity was 72.5%, and specificity was 92.5%. Conclusion: PVI was found to be more specific but less sensitive than dIVC. dIVC is less sensitive and less specific than central venous pressure. However, dIVC and PVI can give useful results in patients who have con- traindication of an invasive technique.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-86727
Ahmet Tamer
{"title":"In Silico Evaluation of SNPs Occurring in DCX and PAFAH1B1 Genes Involved in Embryonic Brain Development: Bioinformatic Study","authors":"Ahmet Tamer","doi":"10.5336/medsci.2021-86727","DOIUrl":"https://doi.org/10.5336/medsci.2021-86727","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-85869
Chairul Arby Desiyanto, Rady Dwipayana, R. Ermawan, Iwan Sutanto, Astri Soetanto, J. Fajar
{"title":"The Efficacy and Safety of Denosumab for Treating Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis","authors":"Chairul Arby Desiyanto, Rady Dwipayana, R. Ermawan, Iwan Sutanto, Astri Soetanto, J. Fajar","doi":"10.5336/medsci.2021-85869","DOIUrl":"https://doi.org/10.5336/medsci.2021-85869","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-87150
Putu Ijiya DANTA AWATARA, A. Kuncoro, Levrita Nindya Poetri, Nuansa Firgie Paramita, J. Fajar, Syifa Mustika
{"title":"Frailty Predicts Outcomes and Prognosis of Liver Cirrhosis Patients: A Meta-Analysis and Systematic Review","authors":"Putu Ijiya DANTA AWATARA, A. Kuncoro, Levrita Nindya Poetri, Nuansa Firgie Paramita, J. Fajar, Syifa Mustika","doi":"10.5336/medsci.2021-87150","DOIUrl":"https://doi.org/10.5336/medsci.2021-87150","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-86357
F. Demir, M. Şahin, Gizem Ergezen
{"title":"Effectiveness of Proprioceptive Exercise on Balance and Sensory Function in Nursing Home Geriatric Individuals with Diabetes: Randomized Controlled Trial","authors":"F. Demir, M. Şahin, Gizem Ergezen","doi":"10.5336/medsci.2021-86357","DOIUrl":"https://doi.org/10.5336/medsci.2021-86357","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-89113
A. Erdal
{"title":"Turkish Plastic Surgeons' Preferences Related to the Inframammary Approach in Breast Augmentation Surgery: A Descriptive Study","authors":"A. Erdal","doi":"10.5336/medsci.2022-89113","DOIUrl":"https://doi.org/10.5336/medsci.2022-89113","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-89203
E. Azapağası, S. Kesici, Bilge Akkaya, Tamer Yoldaş, M. Uysal Yazıcı, Zeynelabidin Öztürk, M. Taşar, U. Örün
ABS TRACT Objective: Cardiogenic shock is acute circulation failure emerg- ing with a linkage to disrupted myocardial contraction. The aim of this study is to identify the underlying etiology, assess the treatment methods, and the long- term prognoses of survivors among the patients admitted to intensive care with cardiogenic shock for the first time and without a previous heart disease history. Material and Methods: This study included patients admitted to the intensive care unit in our hospital for the first time with cardiogenic shock from March 2016 to March 2020. The age interval was 1 month to 18 years. The demographic, clinical, laboratory, and radiological findings for patients were recorded. All pa- tients were evaluated with echocardiography at admission and 12 months after discharge. Results: Of the 24 patients included in this study, 50% were girls (n=12). Nineteen (79.1%) of the 24 patients had acute myocarditis as the underlying cause. Three (12.5%) patients had hypocalcaemia linked to vitamin D de- ficiency, 1 (4.2%) patient had anomalous left coronary artery from the pulmonary artery syndrome, and 1 (4.2%) patient had cardiac tamponade linked to purulent pericarditis. In echocardiographic examinations performed at a 12-month interval, left ventricle ejection fraction increased from 32.45±9.26% to 49.18±15.53%, and left ventricle end-diastolic diameter Z score decreased from 5.65 (4.4) to 2.02 (4.76). Conclusion: With appropriate fluids, diuretic treatment, inotrope man- agement, and extracorporeal support, the prognosis for these patients has clearly improved in recent years.
{"title":"Retrospective Evaluation of the Cases Presenting to the Pediatric Intensive Care Unit with Cardiogenic Shock in Terms of Etiology, Treatment and Long-Term Prognosis","authors":"E. Azapağası, S. Kesici, Bilge Akkaya, Tamer Yoldaş, M. Uysal Yazıcı, Zeynelabidin Öztürk, M. Taşar, U. Örün","doi":"10.5336/medsci.2022-89203","DOIUrl":"https://doi.org/10.5336/medsci.2022-89203","url":null,"abstract":"ABS TRACT Objective: Cardiogenic shock is acute circulation failure emerg- ing with a linkage to disrupted myocardial contraction. The aim of this study is to identify the underlying etiology, assess the treatment methods, and the long- term prognoses of survivors among the patients admitted to intensive care with cardiogenic shock for the first time and without a previous heart disease history. Material and Methods: This study included patients admitted to the intensive care unit in our hospital for the first time with cardiogenic shock from March 2016 to March 2020. The age interval was 1 month to 18 years. The demographic, clinical, laboratory, and radiological findings for patients were recorded. All pa- tients were evaluated with echocardiography at admission and 12 months after discharge. Results: Of the 24 patients included in this study, 50% were girls (n=12). Nineteen (79.1%) of the 24 patients had acute myocarditis as the underlying cause. Three (12.5%) patients had hypocalcaemia linked to vitamin D de- ficiency, 1 (4.2%) patient had anomalous left coronary artery from the pulmonary artery syndrome, and 1 (4.2%) patient had cardiac tamponade linked to purulent pericarditis. In echocardiographic examinations performed at a 12-month interval, left ventricle ejection fraction increased from 32.45±9.26% to 49.18±15.53%, and left ventricle end-diastolic diameter Z score decreased from 5.65 (4.4) to 2.02 (4.76). Conclusion: With appropriate fluids, diuretic treatment, inotrope man- agement, and extracorporeal support, the prognosis for these patients has clearly improved in recent years.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-89293
Güliz Uyar Güleç, Hatice Benli̇can
{"title":"Hospital Infection Rates in Neurology Intensive Care Unit of a University Hospital: Retrospective Study","authors":"Güliz Uyar Güleç, Hatice Benli̇can","doi":"10.5336/medsci.2022-89293","DOIUrl":"https://doi.org/10.5336/medsci.2022-89293","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-87968
P. Sayın, H. S. Türk, Mustafa Altınay, Melis TÜRKEL ÖZKAN, Serkan İslamoğlu, S. Çınar
ABS TRACT Objective: We compared the analgesic efficacy of ultrasonography (USG)-guided quadratus lumborum (QL) and transversus abdominis plane (TAP) blocks in infants undergoing elective unilateral inguinal hernia surgery (IHS). Material and Methods: This single-center, randomized, single-blind, 2-arm clinical trial included 60 infants undergoing elective IHS (aged 1 month to 1 year) with ASA I–II. The patients were randomized into QL block (Group A) and TAP block (Group B) groups. For both groups, 0.3 mL/kg of 0.25% bupivacaine was injected under USG guidance. Age, sex, weight, anesthesia duration (min), surgery duration (min), and recovery duration (min) were recorded. The heart rate (HR) was recorded at baseline, after anesthesia induction, and at 15 and 30 min after the blocks. Postoperatively, patients were evaluated based on their Face, Legs, Activity, Cry, and Consolability (FLACC) scores at 0, 1, 2, 6, 12, and 24 We also recorded the first analgesic duration, analgesic requirement, rescue analgesic requirement, and complications. The primary outcome of the study was FLACC score. Results: Sixty patients completed the study protocol. There were no significant differences between the groups in terms of age, sex, weight, anesthesia duration, surgery duration, recovery duration, or FLACC score or HR in the first 24 h postoperatively. The analgesic requirement, first analgesic requirement time, and rescue analgesic requirement were not significantly different between the groups (p>0.05 for all comparisons). Conclusions: QL and TAP blocks showed similar analgesic efficacy in infants undergoing IHS.
目的:比较超声(USG)引导下腰方肌(QL)和腹横平面(TAP)阻滞在婴儿择期单侧腹股沟疝手术(IHS)中的镇痛效果。材料和方法:这项单中心、随机、单盲、2组临床试验包括60名接受选择性IHS(1个月至1岁)的ASA I-II型婴儿。将患者随机分为QL组(A组)和TAP组(B组)。两组均在USG指导下注射0.25%布比卡因0.3 mL/kg。记录年龄、性别、体重、麻醉时间(min)、手术时间(min)、恢复时间(min)。在基线、麻醉诱导后、阻滞后15和30分钟记录心率(HR)。术后，根据患者的面部、腿部、活动、哭泣和安慰(FLACC)评分0、1、2、6、12和24分对患者进行评估，并记录首次镇痛持续时间、镇痛需求、抢救镇痛需求和并发症。本研究的主要结果为FLACC评分。结果:60例患者完成了研究方案。两组患者在年龄、性别、体重、麻醉时间、手术时间、恢复时间、术后前24 h FLACC评分和HR方面均无显著差异。两组间镇痛需求、首次镇痛需求时间、抢救镇痛需求差异无统计学意义(p < 0.05)。结论:QL阻滞和TAP阻滞对IHS患儿具有相似的镇痛效果。
{"title":"Comparison of Postoperative Analgesic Efficacy Between Ultrasonography-Guided Quadratus Lumborum and Transversus Abdominis Plane Blocks in Infants Undergoing Inguinal Hernia Surgery: Randomized Controlled Trial","authors":"P. Sayın, H. S. Türk, Mustafa Altınay, Melis TÜRKEL ÖZKAN, Serkan İslamoğlu, S. Çınar","doi":"10.5336/medsci.2022-87968","DOIUrl":"https://doi.org/10.5336/medsci.2022-87968","url":null,"abstract":"ABS TRACT Objective: We compared the analgesic efficacy of ultrasonography (USG)-guided quadratus lumborum (QL) and transversus abdominis plane (TAP) blocks in infants undergoing elective unilateral inguinal hernia surgery (IHS). Material and Methods: This single-center, randomized, single-blind, 2-arm clinical trial included 60 infants undergoing elective IHS (aged 1 month to 1 year) with ASA I–II. The patients were randomized into QL block (Group A) and TAP block (Group B) groups. For both groups, 0.3 mL/kg of 0.25% bupivacaine was injected under USG guidance. Age, sex, weight, anesthesia duration (min), surgery duration (min), and recovery duration (min) were recorded. The heart rate (HR) was recorded at baseline, after anesthesia induction, and at 15 and 30 min after the blocks. Postoperatively, patients were evaluated based on their Face, Legs, Activity, Cry, and Consolability (FLACC) scores at 0, 1, 2, 6, 12, and 24 We also recorded the first analgesic duration, analgesic requirement, rescue analgesic requirement, and complications. The primary outcome of the study was FLACC score. Results: Sixty patients completed the study protocol. There were no significant differences between the groups in terms of age, sex, weight, anesthesia duration, surgery duration, recovery duration, or FLACC score or HR in the first 24 h postoperatively. The analgesic requirement, first analgesic requirement time, and rescue analgesic requirement were not significantly different between the groups (p>0.05 for all comparisons). Conclusions: QL and TAP blocks showed similar analgesic efficacy in infants undergoing IHS.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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