Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-90110
Esin Gündem, Y. Elcim
ABS TRACT Objective: Active breathing control (ABC) system ser- ves as a viable technique for the management of respiratory motion by providing reproducible breath-holding. Herein, we assess physical lung dose-volume parameters of V20 (total lung volume receiving ≥ 20 Gy) and mean total lung dose (MLD) in a series of patients receiving split course radiation therapy (SCRT) for advanced-stage non-small cell lung cancer (NSCLC) with the incorporation of the ABC system. Material and Methods: A series of 22 patients receiving ABC-guided SCRT for advanced-stage NSCLC were evaluated for physical lung dose-volume parameters of V20 and MLD. Two different radiation therapy plans have been generated for every patient with and without the incorpora- tion of the ABC system to investigate the dosimetric impact. Results: Mean V20 and MLD were 32.3% and 2,104 cGy, respectively at free- breathing. Mean V20 and MLD were 24.7% and 1,697 cGy, respectively with the incorporation of the ABC system. The decrease in V20 and MLD was 23.53% and 19.34%, respectively. Conclusion: Our study shows improved normal lung tissue sparing by incorporation of ABC system in SCRT of advanced-stage NSCLC. The reduction in V20 and MLD may have clinical implications. Improved normal lung tissue sparing by use of the ABC system may result in an improved toxicity profile of radiation delivery and thereby enable dose escalation in selected patients. Admittedly, clinical follow-up of patients should be performed to elucidate clinical reflections of dosimetric gains achieved by the ABC system.
{"title":"Assessment of Physical Lung Dose-Volume Parameters in Patients Receiving Split Course Radiation Therapy for Advanced-Stage Non Small Cell Lung Cancer: Dosimetric Effect of Active Breathing Control and Clinical Implications: Analytical Research, Case-Control","authors":"Esin Gündem, Y. Elcim","doi":"10.5336/medsci.2022-90110","DOIUrl":"https://doi.org/10.5336/medsci.2022-90110","url":null,"abstract":"ABS TRACT Objective: Active breathing control (ABC) system ser- ves as a viable technique for the management of respiratory motion by providing reproducible breath-holding. Herein, we assess physical lung dose-volume parameters of V20 (total lung volume receiving ≥ 20 Gy) and mean total lung dose (MLD) in a series of patients receiving split course radiation therapy (SCRT) for advanced-stage non-small cell lung cancer (NSCLC) with the incorporation of the ABC system. Material and Methods: A series of 22 patients receiving ABC-guided SCRT for advanced-stage NSCLC were evaluated for physical lung dose-volume parameters of V20 and MLD. Two different radiation therapy plans have been generated for every patient with and without the incorpora- tion of the ABC system to investigate the dosimetric impact. Results: Mean V20 and MLD were 32.3% and 2,104 cGy, respectively at free- breathing. Mean V20 and MLD were 24.7% and 1,697 cGy, respectively with the incorporation of the ABC system. The decrease in V20 and MLD was 23.53% and 19.34%, respectively. Conclusion: Our study shows improved normal lung tissue sparing by incorporation of ABC system in SCRT of advanced-stage NSCLC. The reduction in V20 and MLD may have clinical implications. Improved normal lung tissue sparing by use of the ABC system may result in an improved toxicity profile of radiation delivery and thereby enable dose escalation in selected patients. Admittedly, clinical follow-up of patients should be performed to elucidate clinical reflections of dosimetric gains achieved by the ABC system.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-90290
Burçak Şahin Köze, Meryem Yavuz van Giersbergen, L. Yeniay
ABS
腹肌
{"title":"Quality of Air in the Operating Room: Surgical Smoke-A Descriptive Study","authors":"Burçak Şahin Köze, Meryem Yavuz van Giersbergen, L. Yeniay","doi":"10.5336/medsci.2022-90290","DOIUrl":"https://doi.org/10.5336/medsci.2022-90290","url":null,"abstract":"ABS","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-86890
Esra Sen, H. Dalcik, C. Dalçik
SIRTs are descr i bed i n the deacetylases class III fam i ly. The members wh i ch are i nduced by n i cot i nam i de aden i ne d i nucleot i de (NAD + ) and are closely assoc i ated w i th var i ous deoxyr i bonucle i c ac i d (DNA) h i stone prote i ns. In humans, SIRTs fam i ly i s compo-sed of seven members; SIRT1-SIRT7. The major i ty of SIRTs show NAD + -dependent deacetylase act i v i ty. SIRT4 and SIRT6 funct i on as mono-adenos i ne tr i phosphate-r i bosyl transferase. SIRT5 bes i des deacetylat i on, i t can also generate demalonylat i on and desucc i nylat i on. The presence of SIRTs has been reported to be present i n var i ous compartments i n the cell for example; SIRT1, SIRT6, and SIRT7 was lo-cated i n the nucleus, SIRT3, SIRT4, and SIRT5 i n the m i tochondr i a and SIRT2 i n the cytosol. Recents i nvest i gat i ons demonstrated act i ve i nvolvement of family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and is able to cat-alyze post-translational modifications of proteins. It has been documented that, SIRTs respond to metabolic challenges, inflammation molecules, and oxidative stress. Many studies have linked SIRTs with longevity and having anti-aging activity. Our knowledge of SIRTs in reproduction has grown increasingly over the last few years. The majority of these research is carried out primarily on the effects on SIRT1 on female reproduction. It has been demonstarted that down-regulating SIRT1 trigers the reduc- tion of ovarian reserve. Many research has demonstrated that, SIRT1 regulates proliferation and apoptosis in granulosa cells. Activity studies of SIRTs opened the discoveries of the functional aspects of different types of SIRTs in improving the overall quality of in vitro oocytes in humans and animal models. It has been documented that, SIRT1, SIRT2 and SIRT3 protect oocytes against postovulatory aging. The relationship be- tween derangement of SIRT signaling and the imbalance of reactive oxygen species and antioxidant defenses in female reproductive organs has also been documented. The present review aims to put forward informa-tion on the mechanism and cellular role of SIRTs and give an update of sirtuin research in female reproduction under physiological and patho-logical conditions. The final goal of this work is to put forward the ther- apeutic potential of SIRTs in female infertility.
{"title":"Effects of Sirtuins on Female Reproductivity and Oocyte Quality: Traditional Review","authors":"Esra Sen, H. Dalcik, C. Dalçik","doi":"10.5336/medsci.2021-86890","DOIUrl":"https://doi.org/10.5336/medsci.2021-86890","url":null,"abstract":"SIRTs are descr i bed i n the deacetylases class III fam i ly. The members wh i ch are i nduced by n i cot i nam i de aden i ne d i nucleot i de (NAD + ) and are closely assoc i ated w i th var i ous deoxyr i bonucle i c ac i d (DNA) h i stone prote i ns. In humans, SIRTs fam i ly i s compo-sed of seven members; SIRT1-SIRT7. The major i ty of SIRTs show NAD + -dependent deacetylase act i v i ty. SIRT4 and SIRT6 funct i on as mono-adenos i ne tr i phosphate-r i bosyl transferase. SIRT5 bes i des deacetylat i on, i t can also generate demalonylat i on and desucc i nylat i on. The presence of SIRTs has been reported to be present i n var i ous compartments i n the cell for example; SIRT1, SIRT6, and SIRT7 was lo-cated i n the nucleus, SIRT3, SIRT4, and SIRT5 i n the m i tochondr i a and SIRT2 i n the cytosol. Recents i nvest i gat i ons demonstrated act i ve i nvolvement of family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and is able to cat-alyze post-translational modifications of proteins. It has been documented that, SIRTs respond to metabolic challenges, inflammation molecules, and oxidative stress. Many studies have linked SIRTs with longevity and having anti-aging activity. Our knowledge of SIRTs in reproduction has grown increasingly over the last few years. The majority of these research is carried out primarily on the effects on SIRT1 on female reproduction. It has been demonstarted that down-regulating SIRT1 trigers the reduc- tion of ovarian reserve. Many research has demonstrated that, SIRT1 regulates proliferation and apoptosis in granulosa cells. Activity studies of SIRTs opened the discoveries of the functional aspects of different types of SIRTs in improving the overall quality of in vitro oocytes in humans and animal models. It has been documented that, SIRT1, SIRT2 and SIRT3 protect oocytes against postovulatory aging. The relationship be- tween derangement of SIRT signaling and the imbalance of reactive oxygen species and antioxidant defenses in female reproductive organs has also been documented. The present review aims to put forward informa-tion on the mechanism and cellular role of SIRTs and give an update of sirtuin research in female reproduction under physiological and patho-logical conditions. The final goal of this work is to put forward the ther- apeutic potential of SIRTs in female infertility.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-87662
Elif Özcan, T. Gökbel, C. Cekmece, N. Dursun
{"title":"The Effect of Transcranial Direct Current Stimulation Therapy on Upper Extremity Motor Functions in Patients with Chronic Stroke: A Prospective Randomized Controlled Study","authors":"Elif Özcan, T. Gökbel, C. Cekmece, N. Dursun","doi":"10.5336/medsci.2021-87662","DOIUrl":"https://doi.org/10.5336/medsci.2021-87662","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-84428
Merve Mert, Arman Vahabi, A. Öztürk, H. Erdem, Meltem Işıkgöz Taşbakan
{"title":"Use of Negative Pressure Wound Therapy as an Alternative to Surgical Intervention in Treatment of Soft Tissue Infections","authors":"Merve Mert, Arman Vahabi, A. Öztürk, H. Erdem, Meltem Işıkgöz Taşbakan","doi":"10.5336/medsci.2021-84428","DOIUrl":"https://doi.org/10.5336/medsci.2021-84428","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70783644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-86396
Oylum Hünerel, P. Mutlu, N. Mirici, D. Cakır, H. Türkön, Abdülhakim Hasan Gül
{"title":"Comparison of Biomarkers in Blood and Urine According to Phenotypes in Chronic Obstructive Pulmonary Disease: Cross-Sectional Research","authors":"Oylum Hünerel, P. Mutlu, N. Mirici, D. Cakır, H. Türkön, Abdülhakim Hasan Gül","doi":"10.5336/medsci.2021-86396","DOIUrl":"https://doi.org/10.5336/medsci.2021-86396","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-92588
V. Ünal, Özgür Akşan, Ali Karadağ, S. Özbal, E. Kolatan, Ece SÖKMEN YILMAZ, K. Tuğyan, Nail Özdemir
{"title":"Evaluation of Efficacy of Collagen Material Containing DoubleRelease Gentamicin Sponge in Preventing Postoperative Spinal Infection: Experimental Study (Animal Experiment)","authors":"V. Ünal, Özgür Akşan, Ali Karadağ, S. Özbal, E. Kolatan, Ece SÖKMEN YILMAZ, K. Tuğyan, Nail Özdemir","doi":"10.5336/medsci.2022-92588","DOIUrl":"https://doi.org/10.5336/medsci.2022-92588","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70786384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2020-79999
Selahattin Ayas, Ö. Aydın, G. Benbir Senel, D. Karadeniz
{"title":"Correlation of Clinical and Polysomnographic Data in Paradoxical Insomnia: Case-Control Study","authors":"Selahattin Ayas, Ö. Aydın, G. Benbir Senel, D. Karadeniz","doi":"10.5336/medsci.2020-79999","DOIUrl":"https://doi.org/10.5336/medsci.2020-79999","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70783207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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