Pub Date : 2023-01-01DOI: 10.5336/medsci.2022-90297
F. Öner, Ü. Öner, Osman Kurt, Zeynep Nur İncekara
{"title":"Motivation of Specialist Doctors in Türkiye to Conduct Scientific Research: A Descriptive Study","authors":"F. Öner, Ü. Öner, Osman Kurt, Zeynep Nur İncekara","doi":"10.5336/medsci.2022-90297","DOIUrl":"https://doi.org/10.5336/medsci.2022-90297","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5336/medsci.2022-94617
Mücahide Büşra Balcioğlu, Dilek Kuzay Aksoy, Görkem Tutal Gürsoy, Esra OĞUZ FIRAT, E. E. Tuna, N. Acer
{"title":"Examination of Brain-Derived Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor, and Neurotrophin-3 Levels and Brain Volumes in Shift-Working Men: Clinical Research","authors":"Mücahide Büşra Balcioğlu, Dilek Kuzay Aksoy, Görkem Tutal Gürsoy, Esra OĞUZ FIRAT, E. E. Tuna, N. Acer","doi":"10.5336/medsci.2022-94617","DOIUrl":"https://doi.org/10.5336/medsci.2022-94617","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70786422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5336/medsci.2022-93200
Özgür Akşan, Mehmet Secer
{"title":"Surgical Management of the Hangman's Fracture in the Twelve Cases: Case Series","authors":"Özgür Akşan, Mehmet Secer","doi":"10.5336/medsci.2022-93200","DOIUrl":"https://doi.org/10.5336/medsci.2022-93200","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70786546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5336/medsci.2022-93830
B. Sula, Ü. Ekinci
{"title":"Clinical and Demographic Characteristics of Hidradenitis Suppurativa Patients Application to the Dermatology Clinic of a University Hospital: A Prospective Study","authors":"B. Sula, Ü. Ekinci","doi":"10.5336/medsci.2022-93830","DOIUrl":"https://doi.org/10.5336/medsci.2022-93830","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70786687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5336/medsci.2022-92508
Olga Devrim Ayvaz, A. Celayir
{"title":"Bronchoscopy-Esophagoscopy Experiences of a Pediatric Surgeon: 5 Years Retrospective Study","authors":"Olga Devrim Ayvaz, A. Celayir","doi":"10.5336/medsci.2022-92508","DOIUrl":"https://doi.org/10.5336/medsci.2022-92508","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-86206
A. Yıldız
{"title":"Prolapsed Rectal Lipoma Through the Anus: A Rare Case","authors":"A. Yıldız","doi":"10.5336/medsci.2021-86206","DOIUrl":"https://doi.org/10.5336/medsci.2021-86206","url":null,"abstract":"","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-85395
A. Şahin, E. Kaya, G. Turgut, K. Dolay, A. Kocataş
Objective: Deficiencies in immune-regulatory mechanisms such as immune activation and T-regulatory cells are classically referred to as cytokine storms. Mesenchymal stem cells (MSCs) act as living anti-inflammatory cells that can rebalance cytokine/immune responses to restore balance in patients with coronavirus disease-2019 (COVID-19) acute respiratory distress syndrome by reducing the activation of T and B cells, and dendritic and natural killer cells. The aim of this study is to provide immune modulation with stem cell transplantation by reducing the damage caused and COVID-19 infection to tissues and organs. Material and Methods: In this prospective randomized single-center clinical trial, patients were divided into 3 groups: intubated without comorbidity (n = 7);intubated with comorbidity (n = 7);not intubated (n = 7). Dosage of MSCs transplantation for each group was 1 million cell/kg intravenous at days 0, 2, and 4. age, gender, APACHE II scores, procalcitonin, C-reactive protein (CRP) and leukocyte values, and cluster of difference 4 (CD4), CD8, interleukin 2 (IL-2), and IL-6 levels, morbidities, number of days in intensive care unit, mortality were recorded. Clinical results, changes in inflammatory and immune function levels, and side effects were evaluated. Each patient's improvement in oxygenation and symptoms were recorded in the days after MSC transplantation. After treatment, lymphocyte, CRP, tumor necrosis factor-a level, and IL-6 levels were recorded.
{"title":"Mesenchymal Stem Cell Therapy in COVID-19 Pneumonia: A Prospective, Randomized Clinical Research","authors":"A. Şahin, E. Kaya, G. Turgut, K. Dolay, A. Kocataş","doi":"10.5336/medsci.2021-85395","DOIUrl":"https://doi.org/10.5336/medsci.2021-85395","url":null,"abstract":"Objective: Deficiencies in immune-regulatory mechanisms such as immune activation and T-regulatory cells are classically referred to as cytokine storms. Mesenchymal stem cells (MSCs) act as living anti-inflammatory cells that can rebalance cytokine/immune responses to restore balance in patients with coronavirus disease-2019 (COVID-19) acute respiratory distress syndrome by reducing the activation of T and B cells, and dendritic and natural killer cells. The aim of this study is to provide immune modulation with stem cell transplantation by reducing the damage caused and COVID-19 infection to tissues and organs. Material and Methods: In this prospective randomized single-center clinical trial, patients were divided into 3 groups: intubated without comorbidity (n = 7);intubated with comorbidity (n = 7);not intubated (n = 7). Dosage of MSCs transplantation for each group was 1 million cell/kg intravenous at days 0, 2, and 4. age, gender, APACHE II scores, procalcitonin, C-reactive protein (CRP) and leukocyte values, and cluster of difference 4 (CD4), CD8, interleukin 2 (IL-2), and IL-6 levels, morbidities, number of days in intensive care unit, mortality were recorded. Clinical results, changes in inflammatory and immune function levels, and side effects were evaluated. Each patient's improvement in oxygenation and symptoms were recorded in the days after MSC transplantation. After treatment, lymphocyte, CRP, tumor necrosis factor-a level, and IL-6 levels were recorded.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2022-87999
Olga Devrim Ayvaz, S. Cansaran, Cengiz Gül, A. Celayir
ABS TRACT Objective: Adrenal hemorrhage in newborns is a rare condition with a frequency of 0.2-0.55%. Various risk factors have been reported besides asphyxia resulting from sepsis, coagulation dis-orders and traumatic delivery. In this study, we aimed to evaluate the results of our neonatal cases who were followed-up and treated due to adrenal hemorrhage/mass. Material and Methods: Patients fol-lowed-up(neuroblastoma follow-up protocol)/operated due to adrenal mass between 2007-2021 were retrospectively analyzed. Gender, di- agnosis age-type, laterality data, laboratory-ultrasound(US) findings were recorded and examined. Results: Along 14 years, two patients with bilateral renal hypoplasia of 44 patients who were evaluated with the preliminary diagnosis of adrenal mass were excluded, so 42 pa- tients were included. Eighteen (42.9%) patients were male, 24 (57.1%) were female, 7 were antenatally-diagnosed, mean age of di- agnosis was 11 days in those diagnosed-postnatally. 23 had right, 13 had left, and 6 had bilateral surrenal masses. 38 were cystic, 7 were semisolid, 3 were solid. On the first US, the mean mass size was 34x23mm-the mean mass volume was 12mL. The mean mass size was 31x19mm-the mean mass volume was 8mL in the third month. Urine vanilla mandelic acid levels were normal in all patients. In fol- low-up, three patients were operated because they had solid lesion size over 16mL. One of them underwent pyeloplasty due to uretero- pelvic junction obstruction, two had bening pathology. Conclusion: Differential diagnosis between neonatal neuroblastoma and adrenal hemorrhage can be difficult. Follow-up with US-Doppler US and tumor markers is useful and the most reliable method in distinguish-ing neuroblastoma and adrenal hemorrhage.
{"title":"Management of Neonatal Adrenal Masses: A Single Center Experience: A Retrospective Study","authors":"Olga Devrim Ayvaz, S. Cansaran, Cengiz Gül, A. Celayir","doi":"10.5336/medsci.2022-87999","DOIUrl":"https://doi.org/10.5336/medsci.2022-87999","url":null,"abstract":"ABS TRACT Objective: Adrenal hemorrhage in newborns is a rare condition with a frequency of 0.2-0.55%. Various risk factors have been reported besides asphyxia resulting from sepsis, coagulation dis-orders and traumatic delivery. In this study, we aimed to evaluate the results of our neonatal cases who were followed-up and treated due to adrenal hemorrhage/mass. Material and Methods: Patients fol-lowed-up(neuroblastoma follow-up protocol)/operated due to adrenal mass between 2007-2021 were retrospectively analyzed. Gender, di- agnosis age-type, laterality data, laboratory-ultrasound(US) findings were recorded and examined. Results: Along 14 years, two patients with bilateral renal hypoplasia of 44 patients who were evaluated with the preliminary diagnosis of adrenal mass were excluded, so 42 pa- tients were included. Eighteen (42.9%) patients were male, 24 (57.1%) were female, 7 were antenatally-diagnosed, mean age of di- agnosis was 11 days in those diagnosed-postnatally. 23 had right, 13 had left, and 6 had bilateral surrenal masses. 38 were cystic, 7 were semisolid, 3 were solid. On the first US, the mean mass size was 34x23mm-the mean mass volume was 12mL. The mean mass size was 31x19mm-the mean mass volume was 8mL in the third month. Urine vanilla mandelic acid levels were normal in all patients. In fol- low-up, three patients were operated because they had solid lesion size over 16mL. One of them underwent pyeloplasty due to uretero- pelvic junction obstruction, two had bening pathology. Conclusion: Differential diagnosis between neonatal neuroblastoma and adrenal hemorrhage can be difficult. Follow-up with US-Doppler US and tumor markers is useful and the most reliable method in distinguish-ing neuroblastoma and adrenal hemorrhage.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5336/medsci.2021-84896
Ş. Dokcu, M. Çaparlar, Özhan Çetindağ, A. Eroğlu
ABS TRACT Objective: Surgeries performed for breast cancer often include wide flap practices and breast tissue resections. This condition paves the way for bothersome complications such as seroma, which neg- atively affect patient comfort and also require hospitalization. Hence, surgeons have adopted postoperative drain application as an indispens- able routine. In this study, we aimed to examine the relationship between the weight of resected breast tissue after mastectomy and the postoper- ative drain removal time. Material and Methods: Retrospective medical records of 107 patients who underwent mastectomy procedures due to breast cancer in the surgical oncology clinic were exported from the hospital database. Statistical analyzes were performed within the confi- dence interval of 95%. A p value less than 0.05 was considered statistically significant. Results: The mean age of the patients was 55.13, mean body mass index was 28, mean day of drain removal was 8.45, mean number of lymph nodes removed was 12. Only 47% of the patients had metastatic lymph nodes, with an average of 4.6. We found that the time of drain removal was longer in patients who underwent modified radi- cal mastectomy (MRM) and had axillary lymphatic involvement (p=0.00). In the correlation analysis performed, there was a positive cor- relation between postoperative drain removal time and breast weight (p=0.00), the total number of lymph nodes removed (p=0.00), number of metastatic lymph nodes (p=0.04), and body mass index (p=0.004). Conclusion: Our results are consistent with the current literature, and we recommend being more persistent for drainage practice in patients with axillary involvement, who are overweight and have large breast vol- umes, and not ignoring individual risks in clinical practice.
{"title":"The Relationship Between Drain Removal Day and Breast Weight in Patients with Breast Cancer After Mastectomy: A Retrospective Study","authors":"Ş. Dokcu, M. Çaparlar, Özhan Çetindağ, A. Eroğlu","doi":"10.5336/medsci.2021-84896","DOIUrl":"https://doi.org/10.5336/medsci.2021-84896","url":null,"abstract":"ABS TRACT Objective: Surgeries performed for breast cancer often include wide flap practices and breast tissue resections. This condition paves the way for bothersome complications such as seroma, which neg- atively affect patient comfort and also require hospitalization. Hence, surgeons have adopted postoperative drain application as an indispens- able routine. In this study, we aimed to examine the relationship between the weight of resected breast tissue after mastectomy and the postoper- ative drain removal time. Material and Methods: Retrospective medical records of 107 patients who underwent mastectomy procedures due to breast cancer in the surgical oncology clinic were exported from the hospital database. Statistical analyzes were performed within the confi- dence interval of 95%. A p value less than 0.05 was considered statistically significant. Results: The mean age of the patients was 55.13, mean body mass index was 28, mean day of drain removal was 8.45, mean number of lymph nodes removed was 12. Only 47% of the patients had metastatic lymph nodes, with an average of 4.6. We found that the time of drain removal was longer in patients who underwent modified radi- cal mastectomy (MRM) and had axillary lymphatic involvement (p=0.00). In the correlation analysis performed, there was a positive cor- relation between postoperative drain removal time and breast weight (p=0.00), the total number of lymph nodes removed (p=0.00), number of metastatic lymph nodes (p=0.04), and body mass index (p=0.004). Conclusion: Our results are consistent with the current literature, and we recommend being more persistent for drainage practice in patients with axillary involvement, who are overweight and have large breast vol- umes, and not ignoring individual risks in clinical practice.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"233 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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