Pub Date : 2023-10-01Epub Date: 2023-11-13DOI: 10.1055/a-2174-6948
Laura Schaefer, Elena Kloß, Manfred Henrich, Nina Thom
A 4-year-old, spayed female mixed breed dog was presented with large crater-like, well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated body temperature and lethargy, that began 14 days after vaccination and treatment with fluralaner and milbemycin/praziquantel. Cytology revealed severe pyogranulomatous inflammation with moderate numbers of extracellular microorganisms. Histopathologic examination showed severe multifocal pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe neutrophilic exocytosis with band-like infiltration of the lower portion of the epidermis consistent with pyoderma gangrenosum. Despite intensive immunosuppressive and antimicrobial therapy and intensive inpatient care, the dog was euthanized 16 days after admission due to complications with clinical signs of sepsis, acute dyspnea and thoracic effusion.
{"title":"Extensive fatal Pyoderma gangrenosum in a dog after drug exposure.","authors":"Laura Schaefer, Elena Kloß, Manfred Henrich, Nina Thom","doi":"10.1055/a-2174-6948","DOIUrl":"10.1055/a-2174-6948","url":null,"abstract":"<p><p>A 4-year-old, spayed female mixed breed dog was presented with large crater-like, well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated body temperature and lethargy, that began 14 days after vaccination and treatment with fluralaner and milbemycin/praziquantel. Cytology revealed severe pyogranulomatous inflammation with moderate numbers of extracellular microorganisms. Histopathologic examination showed severe multifocal pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe neutrophilic exocytosis with band-like infiltration of the lower portion of the epidermis consistent with pyoderma gangrenosum. Despite intensive immunosuppressive and antimicrobial therapy and intensive inpatient care, the dog was euthanized 16 days after admission due to complications with clinical signs of sepsis, acute dyspnea and thoracic effusion.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 5","pages":"361-367"},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92157084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2146-6645
Beate Walter
The anti-Mullerian hormone is a glycoprotein secreted by Sertoli cells in males and granulosa cells in females. The initial identification of this hormone in canine and feline serum was achieved in 2011. Meanwhile, a variety of studies have demonstrated its clinical significance as a tool in the endocrine diagnosis. This review summarizes the current knowledge about anti-Mullerian hormone in small animal reproduction and describes future opportunities for its diagnostic usage.
{"title":"[Diagnostic utility of the anti-Mullerian hormone in companion animals].","authors":"Beate Walter","doi":"10.1055/a-2146-6645","DOIUrl":"https://doi.org/10.1055/a-2146-6645","url":null,"abstract":"<p><p>The anti-Mullerian hormone is a glycoprotein secreted by Sertoli cells in males and granulosa cells in females. The initial identification of this hormone in canine and feline serum was achieved in 2011. Meanwhile, a variety of studies have demonstrated its clinical significance as a tool in the endocrine diagnosis. This review summarizes the current knowledge about anti-Mullerian hormone in small animal reproduction and describes future opportunities for its diagnostic usage.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"252-257"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2136-7599
Janine Güldenpfennig, Alexander Bartel, Sebastian Arlt
Objective: Innovative teaching strategies such as case-based learning and hands-on training are more and more integrated into undergraduate veterinary teaching. Nevertheless, it can be assumed that lectures still play an important role in many vet schools. Nowadays, however, lectures are questioned to be motivating and engaging enough for a long-lasting learning retention. In this context, we compared acceptance and learning outcome of the teaching methods reading, writing, and listening to a presentation.
Material and methods: In structured settings based on a cross-over design, 151 students in their fifth year attending a 2-weeks clinical rotation at the Clinic for Animal Reproduction were asked to read papers, listen to a presentation by a lecturer, and to write a summary in group work. Each task dealt with 1 of 3 topics from the field of animal reproduction. A week later, the students were asked to complete a multiple-choice test and an evaluation form. The test contained questions about each of the covered topics as well as a fourth topic, which was not taught in context of this project to assess the students' prior knowledge.
Results: The results revealed that writing a summary in group work led to the best learning outcome, but it cannot be ruled out that learning success may have depended to a large extent on group work. Furthermore, the results did not differ significantly from the second-best teaching method listening to a presentation. The teaching method students preferred most was the lecture, followed by reading papers and writing a summary.
Conclusions: We conclude that presentations by lecturers are still an important teaching method but can be complemented by writing tasks, which may be used in specific settings as a possible way to improve learning outcome in veterinary education.
Conclusion for practice: Our project supports the assumption that more active, student-centered learning approaches such as writing summaries can lead to more engagement and a better learning retention. In addition, training writing skills is important because clinical reports and other written communication are relevant parts of daily veterinary routine.
{"title":"Listening, reading, writing - which method leads to the best learning outcome?","authors":"Janine Güldenpfennig, Alexander Bartel, Sebastian Arlt","doi":"10.1055/a-2136-7599","DOIUrl":"10.1055/a-2136-7599","url":null,"abstract":"<p><strong>Objective: </strong>Innovative teaching strategies such as case-based learning and hands-on training are more and more integrated into undergraduate veterinary teaching. Nevertheless, it can be assumed that lectures still play an important role in many vet schools. Nowadays, however, lectures are questioned to be motivating and engaging enough for a long-lasting learning retention. In this context, we compared acceptance and learning outcome of the teaching methods reading, writing, and listening to a presentation.</p><p><strong>Material and methods: </strong>In structured settings based on a cross-over design, 151 students in their fifth year attending a 2-weeks clinical rotation at the Clinic for Animal Reproduction were asked to read papers, listen to a presentation by a lecturer, and to write a summary in group work. Each task dealt with 1 of 3 topics from the field of animal reproduction. A week later, the students were asked to complete a multiple-choice test and an evaluation form. The test contained questions about each of the covered topics as well as a fourth topic, which was not taught in context of this project to assess the students' prior knowledge.</p><p><strong>Results: </strong>The results revealed that writing a summary in group work led to the best learning outcome, but it cannot be ruled out that learning success may have depended to a large extent on group work. Furthermore, the results did not differ significantly from the second-best teaching method listening to a presentation. The teaching method students preferred most was the lecture, followed by reading papers and writing a summary.</p><p><strong>Conclusions: </strong>We conclude that presentations by lecturers are still an important teaching method but can be complemented by writing tasks, which may be used in specific settings as a possible way to improve learning outcome in veterinary education.</p><p><strong>Conclusion for practice: </strong>Our project supports the assumption that more active, student-centered learning approaches such as writing summaries can lead to more engagement and a better learning retention. In addition, training writing skills is important because clinical reports and other written communication are relevant parts of daily veterinary routine.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"242-251"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2127-5267
Sarah Schmid, Maren Sievert, Axel Wehrend
This case report describes the occurrence of canine herpesvirus 1 in a litter of French bulldogs. In addition, the literature dealing with CHV-1 in puppies is summarized. Two puppies were presented due to dyspnea. During the night, one of them developed diarrhea as well as a highly disturbed general condition and was subsequently euthanized the following day. The second puppy was euthanized 6 hours later with a highly disturbed general condition. Necropsy revealed evidence of canine herpesvirus infection. This was confirmed by a virological examination. The presented case report shows that canine herpesvirus infection must also be considered as a cause of death in newborn puppies in Germany.
{"title":"[Fatalities in a litter of French bulldogs puppies due canine herpesvirus 1].","authors":"Sarah Schmid, Maren Sievert, Axel Wehrend","doi":"10.1055/a-2127-5267","DOIUrl":"10.1055/a-2127-5267","url":null,"abstract":"<p><p>This case report describes the occurrence of canine herpesvirus 1 in a litter of French bulldogs. In addition, the literature dealing with CHV-1 in puppies is summarized. Two puppies were presented due to dyspnea. During the night, one of them developed diarrhea as well as a highly disturbed general condition and was subsequently euthanized the following day. The second puppy was euthanized 6 hours later with a highly disturbed general condition. Necropsy revealed evidence of canine herpesvirus infection. This was confirmed by a virological examination. The presented case report shows that canine herpesvirus infection must also be considered as a cause of death in newborn puppies in Germany.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"278-284"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2147-4051
Alexandra B Zelck, Claudia Köhler, Ingmar Kiefer
Diagnostic imaging represents an important part during modern pregnancy management of the dog. Ultrasound has become the modality of choice for an early pregnancy diagnosis, enabling a verification as early as 17-20 days after LH surge. Furthermore an evaluation of fetal viability and development is possible as well as the depiction of malformations and an early assessment of fetal stress. Doppler imaging may also be of supporting value in this context . Using fetal maturity as well as measurements of fetal and extrafetal structures, a calculation of the gestational age and therefore the time of parturition is achievable. Radiographs of the caudal abdomen enable pregnancy diagnosis from the 43rd day after LH surge onward. In addition, an assessment of fetal size as well as litter size is possible. Both modalities allow for complementary statements concerning possible labor complications and possess supporting value concerning the decision of necessary obstetric intervention and further management in patients with dystocia.
{"title":"[Diagnostic Imaging during pregnancy of the dog].","authors":"Alexandra B Zelck, Claudia Köhler, Ingmar Kiefer","doi":"10.1055/a-2147-4051","DOIUrl":"10.1055/a-2147-4051","url":null,"abstract":"<p><p>Diagnostic imaging represents an important part during modern pregnancy management of the dog. Ultrasound has become the modality of choice for an early pregnancy diagnosis, enabling a verification as early as 17-20 days after LH surge. Furthermore an evaluation of fetal viability and development is possible as well as the depiction of malformations and an early assessment of fetal stress. Doppler imaging may also be of supporting value in this context . Using fetal maturity as well as measurements of fetal and extrafetal structures, a calculation of the gestational age and therefore the time of parturition is achievable. Radiographs of the caudal abdomen enable pregnancy diagnosis from the 43<sup>rd</sup> day after LH surge onward. In addition, an assessment of fetal size as well as litter size is possible. Both modalities allow for complementary statements concerning possible labor complications and possess supporting value concerning the decision of necessary obstetric intervention and further management in patients with dystocia.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"264-275"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2024-02-09DOI: 10.1055/a-2243-2461
Anastasiia Vasetska, Hanna Körber, Caroline Pilgram, Gerhard Schuler, Selim Aslan, Gulsah Saral, Firdevs Binli, Eser Akal, Murat Selcuk, Serhan Ay, Murat Findik, Christelle Speiser Fontaine, Sandra Goericke-Pesch
{"title":"Correction: The use of a 4.7 mg deslorelin slow release implant in male dogs in the field.","authors":"Anastasiia Vasetska, Hanna Körber, Caroline Pilgram, Gerhard Schuler, Selim Aslan, Gulsah Saral, Firdevs Binli, Eser Akal, Murat Selcuk, Serhan Ay, Murat Findik, Christelle Speiser Fontaine, Sandra Goericke-Pesch","doi":"10.1055/a-2243-2461","DOIUrl":"https://doi.org/10.1055/a-2243-2461","url":null,"abstract":"","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"e1"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2150-8971
Lisa Riege, Johanna Leber, Sandra Goericke-Pesch, Beate Walter, Sabine Schäfer-Somi, Iris Reichler, Sebastian Arlt, Axel Wehrend
Wir bieten spezielle reproduktionsmedizinische Dienstleistungen bei Haustieren an, welche unter anderem gynäkologische und andrologische Untersuchungen, Samenkonservierung, Samenübertragungen und Operationen umfassen. Als Tierärztinnen und Tierärzte sehen wir unsere Verpflichtung darin, die Zucht von Tieren nur zu unterstützen, wenn diese unter medizinischen Aspekten für die Zucht geeignet sind. Tiere, welche selbst anatomische Deformationen oder psychische Merkmale aufweisen, welche mit Schmerzen, Leiden oder Schäden verbunden sind, oder bei denen zu erwarten ist, dass Nachkommen unter Problemen leiden werden, welche zu Schmerzen, Leiden oder Schäden führen, sind von der Zucht auszuschließen. Zudem können wir Zuchtpläne nicht unterstützen, wenn ein erhöhtes, voraussehbares Risiko für Geburtsstörungen oder andere Belastungen von Elterntieren oder Nachkommen zu erwarten ist. Weiterhin lehnen wir nicht medizinisch indizierte Operationen und andere Maßnahmen strikt ab, welche anatomische Mängel von Tieren beheben oder verbergen sollen. Die tiermedizinische Notfallversorgung, wie zum Beispiel Geburtshilfe und neonatologische Notfälle, ist von diesen Beschränkungen ausgeschlossen. Eine generelle Listung von Rassen, bei denen wir Dienstleistungen ablehnen, halten wir nicht für sinnvoll, da wir weiterhin den Dialog mit den Tierhaltern und Züchtern beibehalten und für Aufklärung sorgen wollen und es innerhalb jeder Rasse gesündere und weniger gesunde Zuchtlinien bzw. Zuchttiere gibt. Diese Leitlinien geben vor, welche Voraussetzungen Tiere erfüllen müssen, damit wir die Zucht aktiv unterstützen können. Sie beziehen sich im Folgenden vielfach auf das ob struktive Atemnotsyndrom brachyzephaler Hunde [1–3], aber auch auf andere Merkmale. Wir können zuchtunterstützende Maßnahmen nicht anbieten, wenn einer der folgenden Punkte zutrifft: ▪ Anatomische Merkmale, die mit erheblichen körperlichen Leiden verbunden sind und/oder bei denen zu erwarten ist, dass die Nachkommen ebenfalls betroffen sein werden (z. B. starke Faltenbildung [4], massive degenerative Erkrankungen der Gelenke [5]) ▪ Genetische Veränderungen, bei denen zu erwarten ist, dass anatomische Merkmale auftreten, die mit erheblichen körperlichen Leiden verbunden sind und/oder bei denen zu erwarten ist, dass die Nachkommen ebenfalls betroffen sein werden (z. B. bei der Schottischen Faltohrkatze „Scottish Fold“ [6]) Leitlinien für reproduktionsmedizinische Dienstleistungen und Operationen bei Hund und Katze Guidelines for reproductive medicine services and surgery in dogs and cats
{"title":"[Guidelines for reproductive medicine services and surgery in dogs and cats].","authors":"Lisa Riege, Johanna Leber, Sandra Goericke-Pesch, Beate Walter, Sabine Schäfer-Somi, Iris Reichler, Sebastian Arlt, Axel Wehrend","doi":"10.1055/a-2150-8971","DOIUrl":"10.1055/a-2150-8971","url":null,"abstract":"Wir bieten spezielle reproduktionsmedizinische Dienstleistungen bei Haustieren an, welche unter anderem gynäkologische und andrologische Untersuchungen, Samenkonservierung, Samenübertragungen und Operationen umfassen. Als Tierärztinnen und Tierärzte sehen wir unsere Verpflichtung darin, die Zucht von Tieren nur zu unterstützen, wenn diese unter medizinischen Aspekten für die Zucht geeignet sind. Tiere, welche selbst anatomische Deformationen oder psychische Merkmale aufweisen, welche mit Schmerzen, Leiden oder Schäden verbunden sind, oder bei denen zu erwarten ist, dass Nachkommen unter Problemen leiden werden, welche zu Schmerzen, Leiden oder Schäden führen, sind von der Zucht auszuschließen. Zudem können wir Zuchtpläne nicht unterstützen, wenn ein erhöhtes, voraussehbares Risiko für Geburtsstörungen oder andere Belastungen von Elterntieren oder Nachkommen zu erwarten ist. Weiterhin lehnen wir nicht medizinisch indizierte Operationen und andere Maßnahmen strikt ab, welche anatomische Mängel von Tieren beheben oder verbergen sollen. Die tiermedizinische Notfallversorgung, wie zum Beispiel Geburtshilfe und neonatologische Notfälle, ist von diesen Beschränkungen ausgeschlossen. Eine generelle Listung von Rassen, bei denen wir Dienstleistungen ablehnen, halten wir nicht für sinnvoll, da wir weiterhin den Dialog mit den Tierhaltern und Züchtern beibehalten und für Aufklärung sorgen wollen und es innerhalb jeder Rasse gesündere und weniger gesunde Zuchtlinien bzw. Zuchttiere gibt. Diese Leitlinien geben vor, welche Voraussetzungen Tiere erfüllen müssen, damit wir die Zucht aktiv unterstützen können. Sie beziehen sich im Folgenden vielfach auf das ob struktive Atemnotsyndrom brachyzephaler Hunde [1–3], aber auch auf andere Merkmale. Wir können zuchtunterstützende Maßnahmen nicht anbieten, wenn einer der folgenden Punkte zutrifft: ▪ Anatomische Merkmale, die mit erheblichen körperlichen Leiden verbunden sind und/oder bei denen zu erwarten ist, dass die Nachkommen ebenfalls betroffen sein werden (z. B. starke Faltenbildung [4], massive degenerative Erkrankungen der Gelenke [5]) ▪ Genetische Veränderungen, bei denen zu erwarten ist, dass anatomische Merkmale auftreten, die mit erheblichen körperlichen Leiden verbunden sind und/oder bei denen zu erwarten ist, dass die Nachkommen ebenfalls betroffen sein werden (z. B. bei der Schottischen Faltohrkatze „Scottish Fold“ [6]) Leitlinien für reproduktionsmedizinische Dienstleistungen und Operationen bei Hund und Katze Guidelines for reproductive medicine services and surgery in dogs and cats","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"276-277"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-10-11DOI: 10.1055/a-2127-5397
Wolfgang Bäumer, Sonja Bröer
The administration of drugs to pregnant bitches may not only pose a potential danger to the bitch but also to the fetuses. In this context, the extent of the risk also depends on the stage of gestation. Although a number of agents are known to have a fetotoxic and/or teratogenic potential, insufficient knowledge concerning their potential risk to the embryo/fetus is available for the majority of drugs.Arranged in groups of active substances, a selection of drugs that are assumed to be safe according to the current state of knowledge is provided. Drugs for which there is insufficient knowledge or which are clearly contraindicated are also mentioned.The second part of this overview covers the use of medicines in puppies. The physiology of a puppy does not simply correspond to that of a small dog. Only very few drugs posess valid pharmacological data for use in puppies. However, a subset of restrictions on the use of pharmacologic agents may be derived from the specifics of puppy physiology.The recommendations made do not claim to be complete and no guarantee for accuracy is provided, as these have been compiled from a literature review. In certain cases, the recommendations are even contradictory.Veterinarians are therefore encouraged to report all adverse events associated with treatments of pregnant bitches and puppies within the framework of pharmacovigilance. This is the only way to close gaps in knowledge about the treatment of these special patients.
{"title":"[Use of drugs in pregnant dogs and puppies - what should be considered from a pharmacological point of view?]","authors":"Wolfgang Bäumer, Sonja Bröer","doi":"10.1055/a-2127-5397","DOIUrl":"10.1055/a-2127-5397","url":null,"abstract":"<p><p>The administration of drugs to pregnant bitches may not only pose a potential danger to the bitch but also to the fetuses. In this context, the extent of the risk also depends on the stage of gestation. Although a number of agents are known to have a fetotoxic and/or teratogenic potential, insufficient knowledge concerning their potential risk to the embryo/fetus is available for the majority of drugs.Arranged in groups of active substances, a selection of drugs that are assumed to be safe according to the current state of knowledge is provided. Drugs for which there is insufficient knowledge or which are clearly contraindicated are also mentioned.The second part of this overview covers the use of medicines in puppies. The physiology of a puppy does not simply correspond to that of a small dog. Only very few drugs posess valid pharmacological data for use in puppies. However, a subset of restrictions on the use of pharmacologic agents may be derived from the specifics of puppy physiology.The recommendations made do not claim to be complete and no guarantee for accuracy is provided, as these have been compiled from a literature review. In certain cases, the recommendations are even contradictory.Veterinarians are therefore encouraged to report all adverse events associated with treatments of pregnant bitches and puppies within the framework of pharmacovigilance. This is the only way to close gaps in knowledge about the treatment of these special patients.</p>","PeriodicalId":49434,"journal":{"name":"Tieraerztliche Praxis Ausgabe Kleintiere Heimtiere","volume":"51 4","pages":"258-263"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}