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Enhancements in artificial intelligence for medical examinations: A leap from ChatGPT 3.5 to ChatGPT 4.0 in the FRCS trauma & orthopaedics examination.
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-28 DOI: 10.1016/j.surge.2024.11.008
Akib Majed Khan, Khaled Maher Sarraf, Ashley Iain Simpson

Introduction: ChatGPT is a sophisticated AI model capable of generating human-like text based on the input it receives. ChatGPT 3.5 showed an inability to pass the FRCS (Tr&Orth) examination due to a lack of higher-order judgement in previous studies. Enhancements in ChatGPT 4.0 warrant an evaluation of its performance.

Methodology: Questions from the UK-based December 2022 In-Training examination were input into ChatGPT 3.5 and 4.0. Methodology from a prior study was replicated to maintain consistency, allowing for a direct comparison between the two model versions. The performance threshold remained at 65.8 %, aligning with the November 2022 sitting of Section 1 of the FRCS (Tr&Orth).

Results: ChatGPT 4.0 achieved a passing score (73.9 %), indicating an improvement in its ability to analyse clinical information and make decisions reflective of a competent trauma and orthopaedic consultant. Compared to ChatGPT 4.0, version 3.5 scored 38.1 % lower, which represents a significant difference (p < 0.0001; Chi-square). The breakdown by subspecialty further demonstrated version 4.0's enhanced understanding and application in complex clinical scenarios. ChatGPT 4.0 had a significantly significant improvement in answering image-based questions (p = 0.0069) compared to its predecessor.

Conclusion: ChatGPT 4.0's success in passing Section One of the FRCS (Tr&Orth) examination highlights the rapid evolution of AI technologies and their potential applications in healthcare and education.

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引用次数: 0
A boost to concentration or a distracting noise? A systematic review of surgeon and anaesthetist perspectives of the benefit of intra-operative music. 是提高注意力还是分散注意力的噪音?系统回顾外科医生和麻醉师对术中音乐益处的看法。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-25 DOI: 10.1016/j.surge.2024.11.002
K Onuoha, D Jones, W Eardley

Background: The surgical team should be as harmonious and focussed as possible in the operating theatre. Whilst there is evidence of benefit for the use of music in the perioperative period for patient, little exists to inform of impact on those doing the surgery or anaesthesia. This review focuses on the perspectives of surgeons and anaesthetists, their views and opinions on the effect and impact of music during surgery.

Methods: A systematic review was conducted using narrative synthesis. The PRISMA guidelines were followed with the use of PICO and PRISMA guided search strategy. PubMed, CINAHL and Medline were searched but filtered to only published English language papers.

Results: Of 329 papers identified 42 duplicates were removed. 287 were screened; of which 276 were excluded and 11 sought for retrieval. Of these, 8 were excluded for wrong population or study design, leaving 3 for analysis. Narrative synthesis revealed three themes to guide discussion: (1) Views of surgeons and anaesthetists and the effect on music; (2) effect of music on other staff members; and (3) differences in music choices and balance of power.

Conclusion: Music has an overall beneficial effect on surgeons and anaesthetists, especially with regards improved concentration. As an intervention, it has global generalisability and requires little resource. Investigation across different surgical specialities and use of flexible control models in terms of choosing music is a natural subsequent research question.

背景:在手术室中,手术团队应尽可能保持和谐并集中精力。虽然有证据表明在围手术期使用音乐对病人有益,但很少有资料能说明音乐对手术或麻醉人员的影响。本综述侧重于外科医生和麻醉师的观点,以及他们对手术期间音乐的效果和影响的看法和意见:方法:采用叙事综合法进行系统综述。方法:采用叙事综合法进行了系统综述,并遵循了 PRISMA 指南,使用了 PICO 和 PRISMA 引导的搜索策略。对 PubMed、CINAHL 和 Medline 进行了检索,但只筛选了已发表的英文论文:在确定的 329 篇论文中,删除了 42 篇重复论文。筛选出 287 篇,其中 276 篇被排除,11 篇需要检索。其中 8 篇因研究对象或研究设计错误而被排除,剩下 3 篇用于分析。叙事综述揭示了引导讨论的三个主题:(1) 外科医生和麻醉师的观点及对音乐的影响;(2) 音乐对其他工作人员的影响;(3) 音乐选择的差异和权力平衡:音乐对外科医生和麻醉师总体上有好处,尤其是在提高注意力方面。作为一种干预措施,它具有全球普遍性,而且所需资源很少。对不同外科专业进行调查,并在选择音乐方面使用灵活的控制模型,自然是后续研究的一个问题。
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引用次数: 0
List of editors 编辑名单
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-22 DOI: 10.1016/S1479-666X(24)00139-2
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引用次数: 0
Surgeon ability to predict physical activity and sedentary time: Comparison of self-reported and measured activity 外科医生预测体力活动和久坐时间的能力:自我报告活动量与测量活动量的比较
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-22 DOI: 10.1016/j.surge.2024.09.008
Stefanie Soelling , Stephanie Polazzi , Jean-Christophe Lifante , Tanujit Dey , Antoine Duclos

Background

Prior work evaluated clinician work-related physical activity and found it does not meet recommended requirements. We aimed to assess more fully daily surgeon physical activity and compare it to self-reported activity.

Methods

This multispecialty prospective cohort study included attending surgeons from 14 surgical departments within four French university hospitals. Over a 14-month period (11/01/2020-12/31/2021), surgeons were continuously monitored 24/7 for their daily physical activity by wearing an accelerometer on their ankle. For each surgeon, measured parameters included the daily average of step counts and sedentary time, as well as the total weekly time of physical activity within the 30 days preceding surgeries. Surgeons self-reported the validated Global Physical Activity Questionnaire from the World Health Organization (WHO). The self-reported and measured physical activity of surgeons were described, and their correlation was assessed using Spearman rank correlation.

Results

Overall, there were 38 surgeons in the cohort and 8810 surgeries performed. Surgeons were 78.9 % male, median age was 46.1, and median BMI was 24.5. Median measured daily step count was 9439 (IQR: 7238–9918). The measured weekly total time of physical activity was 918 min (95 % CI: 767–990), while the corresponding self-reported median time was 1940 min (95 % CI: 1120–3600) (Spearman coefficient = 0.14, p = 0.41). The measured median daily sedentary time was 353 min (95 % CI: 316–374), compared to a self-reported median of 240 min (95 % CI: 210–300) (Spearman coefficient = 0.20, p = 0.24).

Conclusions

Surgeons may overestimate the sufficiency of their physical activity and underestimate their sedentary time. Increased awareness is needed to improve surgeon wellness.
背景先前的研究对临床医生与工作相关的体力活动进行了评估,发现其并不符合推荐要求。我们的目的是更全面地评估外科医生的日常体力活动,并将其与自我报告的活动进行比较。方法这项多专科前瞻性队列研究包括法国四所大学医院 14 个外科部门的主治外科医生。在为期 14 个月(2020 年 1 月 11 日至 2021 年 1 月 12 日)的时间里,外科医生脚踝上佩戴的加速度计对其日常体力活动进行全天候连续监测。每位外科医生的测量参数包括每日平均步数和久坐时间,以及手术前 30 天内每周的总体力活动时间。外科医生自我报告了世界卫生组织(WHO)经过验证的全球体力活动调查问卷。对外科医生自我报告的体力活动和测量的体力活动进行了描述,并使用斯皮尔曼等级相关性评估了它们之间的相关性。外科医生中 78.9% 为男性,年龄中位数为 46.1 岁,体重指数中位数为 24.5。测量的每日步数中位数为 9439 步(IQR:7238-9918)。测得的每周总运动时间为 918 分钟(95 % CI:767-990),而相应的自我报告时间中位数为 1940 分钟(95 % CI:1120-3600)(斯皮尔曼系数 = 0.14,P = 0.41)。测量的每日久坐时间中位数为 353 分钟(95 % CI:316-374),而自我报告的中位数为 240 分钟(95 % CI:210-300)(Spearman 系数 = 0.20,p = 0.24)。要改善外科医生的健康状况,就必须提高对这一问题的认识。
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引用次数: 0
Sensitivity and specificity of surgeons' intra-operative diagnosis of appendicitis. A systematic review and meta-analysis. 外科医生术中诊断阑尾炎的敏感性和特异性。系统回顾和荟萃分析。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-20 DOI: 10.1016/j.surge.2024.10.006
Ellen Barnes, Rian Hayes, Sarah Louise Halpin, Sana Nasim

Background: Appendicitis is a frequently encountered surgical condition, yet its diagnosis can be challenging. There is increasing research on the safety of leaving macroscopically normal appendices in situ, the necessity of routine histopathological assessment, and the impact of the intra-operative assessment on the post-operative course. We aimed to determine the sensitivity and specificity of the surgeon's intra-operative diagnosis of appendiceal pathology, which is an important factor in answering these questions.

Methods: Medline, Embase, the Cochrane Library and Web of Science were searched for studies listing the corresponding intra-operative and histopathological diagnoses of appendicectomies performed for suspected appendicitis. The primary outcome was the sensitivity and specificity of the surgeon at recognising an abnormal appendix, which we subjected to meta-analysis. Subgroup analysis was performed for paediatric and adult populations. Incidence of unexpected findings and if they were recognised intra-operatively was recorded.

Result: 42 articles were included in the systematic review. 26 studies featuring 17,374 patients were included in the meta-analysis, which found that surgeons' intra-operative diagnosis was 95.2 % (95 % CI 94.8-95.5 %) sensitive and 60 % (95 % CI 58.1-62 %) specific. Surgeons are slightly more sensitive and specific in paediatric populations (sensitivity 95.7 % (95 % CI 95-96.4 %), specificity 64.1 % (95 % CI 60-68 %)) compared with adult populations (sensitivity 93 % (95 % CI 91.3-94.5 %), specificity 56.5 % (95 % CI 50.1-62.6 %)), however, this difference was only statistically significant in sensitivity. 1.7 % of appendicectomy specimens had unexpected histopathological findings, of which very few were suspected intra-operatively.

Conclusion: Surgeons are highly sensitive but not very specific at recognising abnormal appendices intra-operatively.

背景:阑尾炎是外科手术中经常遇到的病症,但其诊断却极具挑战性。越来越多的研究涉及将宏观正常阑尾留在原位的安全性、常规组织病理学评估的必要性以及术中评估对术后病程的影响。我们的目的是确定外科医生术中诊断阑尾病变的敏感性和特异性,这是回答这些问题的重要因素:方法:在 Medline、Embase、Cochrane 图书馆和 Web of Science 中检索了列出因疑似阑尾炎而进行阑尾切除术的术中诊断和组织病理学诊断的研究。主要结果是外科医生识别异常阑尾的敏感性和特异性,我们对其进行了荟萃分析。我们对儿科和成人人群进行了分组分析。我们还记录了意外发现的发生率以及是否在术中被识别出来。荟萃分析发现,外科医生术中诊断的敏感度为 95.2%(95% CI 94.8-95.5%),特异度为 60%(95% CI 58.1-62%)。与成人(灵敏度 93 % (95 % CI 91.3-94.5 %),特异性 56.5 % (95 % CI 50.1-62.6 %))相比,外科医生对儿科患者的敏感度和特异性略高一些(灵敏度 95.7 % (95 % CI 95-96.4 %),特异性 64.1 % (95 % CI 60-68 %)),但这一差异仅在灵敏度方面具有统计学意义。1.7%的阑尾切除标本有意外的组织病理学发现,其中极少数是术中怀疑的:结论:外科医生在术中识别异常阑尾的敏感性很高,但特异性不高。
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引用次数: 0
Use of the contour ® curved cutter stapler device for rectal transection during robotic assisted surgery. 在机器人辅助手术中使用轮廓 ® 弯刀订书机装置进行直肠横切。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-20 DOI: 10.1016/j.surge.2024.11.007
Fraser Sneddon, Colin H Richards, Raymond Oliphant

Background: Rectal division during minimally invasive surgery including robotic assisted surgery remains challenging, with current techniques often requiring multiple stapler firings to achieve effective transection.

Aims: We propose a novel technique which allows the use of a Contour® Curved Cutter Stapler to achieve rectal division during robotic assisted surgery.

Methods: The stapler is inserted through the routinely made pfannenstiel incision and a glove, over an Alexis® port used to create an airtight seal.

Conclusion: This simple technique enables reliable perpendicular single stapler firing to achieve rectal transection during colorectal robotic assisted surgery without the requirement for any further incisions.

背景:在包括机器人辅助手术在内的微创手术中进行直肠分割仍然具有挑战性,目前的技术通常需要多次发射订书机才能实现有效横断。目的:我们提出了一种新技术,允许在机器人辅助手术中使用 Contour® 弯刀订书机实现直肠分割:方法:通过常规的pfannenstiel切口和手套将订书机插入Alexis®端口,以形成气密性密封:结论:这项简单的技术可在结肠直肠机器人辅助手术中实现可靠的垂直单订书机发射,以实现直肠横断,而无需任何进一步的切口。
{"title":"Use of the contour ® curved cutter stapler device for rectal transection during robotic assisted surgery.","authors":"Fraser Sneddon, Colin H Richards, Raymond Oliphant","doi":"10.1016/j.surge.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.surge.2024.11.007","url":null,"abstract":"<p><strong>Background: </strong>Rectal division during minimally invasive surgery including robotic assisted surgery remains challenging, with current techniques often requiring multiple stapler firings to achieve effective transection.</p><p><strong>Aims: </strong>We propose a novel technique which allows the use of a Contour® Curved Cutter Stapler to achieve rectal division during robotic assisted surgery.</p><p><strong>Methods: </strong>The stapler is inserted through the routinely made pfannenstiel incision and a glove, over an Alexis® port used to create an airtight seal.</p><p><strong>Conclusion: </strong>This simple technique enables reliable perpendicular single stapler firing to achieve rectal transection during colorectal robotic assisted surgery without the requirement for any further incisions.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Score card for individual contribution to global and remote surgery. 全球和远程外科手术个人贡献计分卡。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-14 DOI: 10.1016/j.surge.2024.11.006
Rahul M Jindal
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引用次数: 0
Clinical predictors of recurrent cholecystitis in non-operative management: A systematic review & meta-analysis. 非手术治疗中复发性胆囊炎的临床预测因素:系统回顾与荟萃分析。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-13 DOI: 10.1016/j.surge.2024.11.004
Ahmed Salama, Gavin G Calpin, Raymond Fuller, Arnold D K Hill

Introduction: Gallstone disease is prevalent and carries substantial implications for morbidity and healthcare resource utilization. While early laparoscopic cholecystectomy (LC) is often preferred, its feasibility may be limited in some cases. As a result, many patients undergo conservative management.

Aims: To conduct a systematic review of the current literature to identify studies reporting on clinical predictors of recurrence in patients who undergo non-operative management of acute cholecystitis.

Methods: A systematic review was performed as per PRISMA and MOOSE guidelines. Studies comparing variables in patients who had acute cholecystitis recurrence (ACR) were included.

Results: Three studies were included in the review. There were 678 patients in total with a 28.5 % recurrence rate. Age, history of biliary disease, and severity of cholecystitis were identified as potential predictors of ACR. Biochemical results, such as inflammatory markers, white cells, and albumin levels, may also play a role. Radiological findings, including gallbladder wall thickness and stone characteristics, showed potential as predictors.

Conclusion: Identifying patients at risk of recurrent cholecystitis is important in guiding clinical decision-making. While certain findings show promise as predictors, the available evidence is limited and inconclusive. Larger studies are needed to develop risk stratification tools for better management of gallstone disease.

导言:胆石症很普遍,对发病率和医疗资源利用率有很大影响。虽然早期腹腔镜胆囊切除术(LC)通常是首选,但在某些病例中其可行性可能有限。目的:对现有文献进行系统性回顾,以确定对急性胆囊炎进行非手术治疗的患者复发的临床预测因素:方法:根据 PRISMA 和 MOOSE 指南进行系统性综述。方法:根据PRISMA和MOOSE指南进行了系统性综述,纳入了对急性胆囊炎复发(ACR)患者的变量进行比较的研究:结果:共纳入三项研究。共有 678 名患者,复发率为 28.5%。年龄、胆道疾病史和胆囊炎的严重程度被认为是 ACR 的潜在预测因素。生化检查结果,如炎症标志物、白细胞和白蛋白水平,也可能是影响因素之一。包括胆囊壁厚度和结石特征在内的放射学检查结果也有可能成为预测因素:结论:识别有复发性胆囊炎风险的患者对于指导临床决策非常重要。虽然某些检查结果显示有可能成为预测指标,但现有的证据有限且不确定。需要进行更大规模的研究来开发风险分层工具,以便更好地管理胆石症。
{"title":"Clinical predictors of recurrent cholecystitis in non-operative management: A systematic review & meta-analysis.","authors":"Ahmed Salama, Gavin G Calpin, Raymond Fuller, Arnold D K Hill","doi":"10.1016/j.surge.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.surge.2024.11.004","url":null,"abstract":"<p><strong>Introduction: </strong>Gallstone disease is prevalent and carries substantial implications for morbidity and healthcare resource utilization. While early laparoscopic cholecystectomy (LC) is often preferred, its feasibility may be limited in some cases. As a result, many patients undergo conservative management.</p><p><strong>Aims: </strong>To conduct a systematic review of the current literature to identify studies reporting on clinical predictors of recurrence in patients who undergo non-operative management of acute cholecystitis.</p><p><strong>Methods: </strong>A systematic review was performed as per PRISMA and MOOSE guidelines. Studies comparing variables in patients who had acute cholecystitis recurrence (ACR) were included.</p><p><strong>Results: </strong>Three studies were included in the review. There were 678 patients in total with a 28.5 % recurrence rate. Age, history of biliary disease, and severity of cholecystitis were identified as potential predictors of ACR. Biochemical results, such as inflammatory markers, white cells, and albumin levels, may also play a role. Radiological findings, including gallbladder wall thickness and stone characteristics, showed potential as predictors.</p><p><strong>Conclusion: </strong>Identifying patients at risk of recurrent cholecystitis is important in guiding clinical decision-making. While certain findings show promise as predictors, the available evidence is limited and inconclusive. Larger studies are needed to develop risk stratification tools for better management of gallstone disease.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"We are very family like": How do relationships with colleagues affect career satisfaction for surgeons? "我们就像一个大家庭与同事的关系如何影响外科医生的职业满意度?
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-11 DOI: 10.1016/j.surge.2024.11.005
Leeat Granek, Abhaya V Kulkarni, David J Barron, Agnes M F Wong

Purpose: The objective of this research was to explore the role of surgeon relationships with their colleagues on career satisfaction.

Methods: This qualitative study employed a thematic analysis based on the core elements of The Grounded Theory Method. Forty-two pediatric neurosurgeons, cardio-thoracic surgeons and ophthalmologists were recruited from 9 countries around the globe and interviewed in-depth about the role of their collegial relationships on their career satisfaction. Data was coded line-by-line to extract themes and to identify patterns across the interviews.

Results: Career satisfaction was greatly enhanced by having a cohesive and healthy team. 'Healthy' teams were described as those that were emotionally supportive of each other, where colleagues could be trusted to back each other up, where communication was open and transparent, and where collaboration was the departmental norm. Career satisfaction was greatly diminished when there were interpersonal conflicts and personality clashes between surgeons, where there was poor departmental leadership creating a culture of fear and insecurity, when colleagues were perceived as egotistical, in competitive departments, where there was perceived to be an unequal distribution of work, and when surgeons felt alone and unsupported.

Conclusions: Our study found that healthy teams had very specific qualities that could be cultivated and enhanced on surgical teams by making a conscious effort to improve the workplace culture and psychological safety among the team. In the conclusions, a number of recommendations are made on how to go about achieving this goal.

目的:本研究旨在探讨外科医生与同事的关系对职业满意度的影响:这项定性研究采用了基于基础理论方法核心要素的主题分析法。研究人员从全球 9 个国家招募了 42 名儿科神经外科医生、心胸外科医生和眼科医生,就同事关系对其职业满意度的影响进行了深入访谈。我们对数据进行了逐行编码,以提取主题并确定访谈的模式:结果:拥有一个有凝聚力和健康的团队可以大大提高职业满意度。健康 "的团队被描述为在情感上相互支持、同事之间可以相互信任、沟通公开透明、合作成为部门规范的团队。当外科医生之间存在人际冲突和性格不合时,当部门领导不力造成恐惧和不安全感时,当同事被认为自负时,当部门竞争激烈时,当工作分配不均时,当外科医生感到孤独和缺乏支持时,职业满意度就会大大降低:我们的研究发现,健康的团队具有非常特殊的品质,可以通过有意识地改善工作场所文化和团队中的心理安全来培养和提高外科团队的品质。在结论中,我们就如何实现这一目标提出了一些建议。
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引用次数: 0
Comparative analysis of bone and soft tissue vs. visceral synovial sarcoma: Demographic, clinical, and survival outcomes; a retrospective population-based study. 骨和软组织肉瘤与内脏滑膜肉瘤的比较分析:人口统计学、临床和生存结果;一项基于人群的回顾性研究。
IF 2.3 4区 医学 Q2 SURGERY Pub Date : 2024-11-10 DOI: 10.1016/j.surge.2024.11.003
Asad Ullah, Mya Goodbee, Kali Malham, Abdul Qahar Khan Yasinzai, Muhammad Bilal Mirza, Bisma Tareen, Aimal Khan, Kamran Idrees

Background: Synovial sarcoma (SS) is typically diagnoses in young adults and usually appears in the extremities and soft tissues. However, it can sometimes arise in visceral organs. This study examines the differences in patient demographics, clinical features, and survival rates between soft tissue and visceral synovial sarcoma.

Methods: We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database spanning 2000-2018. ANOVA (analysis of variance) was used to identify significant factors for multivariate analysis. Cox regression modeling was used to determine independent risk factors for survival.

Results: Of the 2,776 SS patients included, the median age was 39.0 years, predominating male (53.0 %) and white (81.3 %). Bone and soft tissue sarcomas were more common, accounting for 86.4 % of cases (p-value<0.001), while the rest were diagnosed as visceral sarcomas. Visceral SS patients were typically older (p-value<0.001), male (56.8 %), and white (84.8 %). They also presented more frequently with distant metastasis (HR 3.8, 95 % CI, 2.4-6.1), had larger tumors on average (HR for tumors >10 cm: 2.9, 95 % CI, 2.0-4.1), and were less likely to undergo surgery (HR 0.4, 95 % CI, 0.3-0.6). Despite receiving multimodal treatments, including surgery, radiation, and/or chemotherapy, visceral SS patients exhibited poorer overall survival compared to their bone and soft tissue SS counterparts (p-value<0.001).

Conclusion: Visceral SS often presents in older patients with advanced-stage and larger tumor size as compared to bone and soft tissue SS, which likely contributes to poorer survival. Advanced age, regional spread, and larger tumor size were all found to worsen outcomes, while surgery and radiation were found to be protective factors.

背景:滑膜肉瘤(SS)通常诊断为青壮年,通常出现在四肢和软组织。但有时也会出现在内脏器官中。本研究探讨了软组织滑膜肉瘤和内脏滑膜肉瘤在患者人口统计学、临床特征和存活率方面的差异:我们分析了 2000-2018 年间来自监测、流行病学和最终结果(SEER)数据库的数据。采用方差分析(ANOVA)来确定进行多变量分析的重要因素。Cox回归模型用于确定生存的独立风险因素:在纳入的 2,776 例 SS 患者中,中位年龄为 39.0 岁,男性(53.0%)和白人(81.3%)占多数。骨和软组织肉瘤更为常见,占病例总数的86.4%(P值10 cm:2.9,95 % CI,2.0-4.1),接受手术的可能性较低(HR 0.4,95 % CI,0.3-0.6)。尽管接受了包括手术、放疗和/或化疗在内的多模式治疗,内脏癌患者的总生存率仍低于骨癌和软组织癌患者(P-value):与骨和软组织内脏癌相比,内脏癌患者通常年龄较大、处于晚期且肿瘤体积较大,这可能是导致患者生存率较低的原因之一。研究发现,高龄、区域扩散和肿瘤体积增大都会导致预后恶化,而手术和放射治疗则是保护性因素。
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引用次数: 0
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Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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