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Impact of facility volume on outcomes in primary malignant spinal intramedullary tumors. 设施体积对原发性恶性脊髓内肿瘤预后的影响。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.spinee.2025.12.018
Ataollah Shahbandi, Peter Palmer, Kevin Wojcik, Pegah Ghamasaee, Saman Shabani
<p><strong>Background context: </strong>The impact of facility volume on patient outcomes for primary malignant intramedullary tumors remains unclear.</p><p><strong>Purpose: </strong>This study aimed to evaluate survival differences based on facility volume, analyze variations in treatment approaches among high- and low-volume facilities, and assess the independent association between facility caseload and survival as well as perioperative outcomes.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Patient sample: </strong>This study utilized data from the National Cancer Database from 2004 to 2022. Patients diagnosed with primary malignant spinal intramedullary tumors were included in this study.</p><p><strong>Outcome measures: </strong>The primary outcome was overall survival (OS), while secondary outcomes included treatment utilization and perioperative outcomes in surgically treated patients.</p><p><strong>Methods: </strong>To determine the optimal case volume cutoff for predicting survival, maximally selected rank statistics were utilized, indicating a threshold of 29 cases from 2004 to 2022. Patients were categorized based on facility volume: high-volume facilities (>29 cases over the study period) and low-volume facilities (≤29 cases). Secondary analyses included contemporaneous facility volume definition based on a five-year rolling basis, a time-indexed facility volume definition, and modeling facility volume as a continuous variable. Differences in categorical variables were assessed using Fisher's exact test or Pearson's chi-square test, while continuous variables were compared using an independent samples t-test. Kaplan-Meier survival curves were generated to visualize OS based on facility volume. Univariate Cox proportional hazards regression models estimated mortality risk based on patient and disease characteristics. Variables with p<.2 in univariate analysis were entered into a multivariate Cox model to identify independent predictors of mortality. Regarding treatment utilization and perioperative outcomes, baseline variables with p<.2 in the univariate analysis were included in the multivariate logistic regression model to determine the independent association between facility volume and treatment selection, as well as perioperative outcomes. Poisson regression models were used to assess temporal trends in treatment utilization.</p><p><strong>Results: </strong>A total of 3,353 patients were included, with 522 treated at high-volume facilities and 2,831 at low-volume facilities. Treatment at high-volume facilities was associated with significantly improved OS (p<.001), with a 10-year survival rate of 81.4% compared to 69.6% at low-volume facilities. During the study period, the use of surgical procedures, radiation therapy, and systemic therapies remained stable within high-volume facilities. In contrast, within low-volume facilities, there was a significant increase in the use of surgical procedures f
背景:设施体积对原发性恶性髓内肿瘤患者预后的影响尚不清楚。目的:本研究旨在评估基于设施容量的生存差异,分析高容量和低容量设施之间治疗方法的差异,并评估设施病例量与生存以及围手术期结果之间的独立关联。研究设计:回顾性队列研究。患者样本:本研究使用了2004年至2022年国家癌症数据库的数据。诊断为原发性恶性脊髓内肿瘤的患者纳入本研究。结果指标:主要结果是总生存期(OS),次要结果包括手术治疗患者的治疗利用率和围手术期结果。方法:为了确定预测生存的最佳病例量临界值,采用最大选择秩统计,2004年至2022年的阈值为29例。根据设施容量对患者进行分类:高容量设施(研究期间bbb29例)和小容量设施(≤29例)。二次分析包括基于五年滚动基础的同期设施体积定义,时间索引设施体积定义,以及将设施体积建模为连续变量。分类变量间的差异采用Fisher精确检验或Pearson卡方检验,而连续变量间的差异采用独立样本t检验。生成Kaplan-Meier生存曲线,以可视化基于设施体积的OS。单变量Cox比例风险回归模型基于患者和疾病特征估计死亡风险。将单因素分析中P < 0.2的变量输入多因素Cox模型,以确定死亡率的独立预测因子。对于治疗利用和围手术期结局,将单因素分析中P < 0.2的基线变量纳入多因素logistic回归模型,以确定设施容量与治疗选择及围手术期结局之间的独立关联。泊松回归模型用于评估治疗利用的时间趋势。结果:共纳入3353例患者,其中522例在大容量设施治疗,2831例在小容量设施治疗。大容量设施的治疗与显著改善的OS相关(P < 0.001), 10年生存率为81.4%,而小容量设施的10年生存率为69.6%。在研究期间,外科手术、放射治疗和全身治疗的使用在大容量设施内保持稳定。相比之下,在小容量设施中,在研究期间,外科手术治疗肿瘤的使用显著增加(比率比1.021,95% CI 1.011-1.032; P < 0.001),放射治疗(比率比0.971,95% CI 0.955-0.987; P < 0.001)和全身治疗的使用显著下降(RR 0.97, 95% CI 0.941-0.999; P = 0.046)。在调整混杂变量后,较高的设施体积仍然与较低的死亡风险(风险比0.996,95%可信区间[CI] 0.992-0.999; P = 0.022)、较高的手术切除几率(优势比1.006,95% CI 1.001-1.011; P = 0.01)、较低的接受放射治疗的可能性(优势比0.988,95% CI 0.984-0.992;P < 0.001),手术切除后30天再入院率显著降低(优势比0.987,95% CI 0.976-0.996; P = 0.007)。结论:尽管原发性恶性髓内肿瘤罕见,但在大容量设施治疗可显著提高生存率,并降低手术切除后30天再入院率。这些发现强调了专业中心在优化患者预后方面的重要性,并可以为这些复杂肿瘤的转诊模式和治疗策略提供信息。
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引用次数: 0
Health access, health disparities, and Medicare's transforming episode accountability model (TEAM) in the field of spine surgery. 脊柱外科领域的健康获取、健康差异和医疗保险的转变事件责任模型(TEAM)。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.spinee.2025.12.014
Patrick K Cronin, Joshua M Coan, Kate E Drabenstott, Andrea L Choi, Andrew J Schoenfeld

In the past, many health reform efforts have been touted as a means to tangentially reduce healthcare disparities. Few have shown any demonstrable efficacy in this arena. There is reasonable concern that the machinations of Medicare's Transforming Episode Accountability Model (TEAM) may also exert unintended effects on health access and delivery, potentially worsening existent disparities for racial and ethnic minorities as well as other vulnerable populations. As TEAM has yet to be implemented, this review intends to prognosticate potential pitfalls and behaviors that may be motivated by this project that could otherwise lead to worsening healthcare disparities within spine fusion care. We present a narrative review with our prognostications regarding mechanisms and behaviors that may be influenced by TEAM and that could result in worsening healthcare disparities and/or reduced access to care for vulnerable populations. These are informed by published experiences with other health reform efforts including centers of excellence, bundled payment programs, Accountable Care Organizations and Comprehensive Care for Joint Replacement. Based on previous published experiences with similar health reform initiatives, we believe there are several areas in which TEAM may potentiate or worsen existing healthcare disparities. These include the areas of access to care, undertreatment and healthcare segregation, as well as adverse behaviors such as cherry picking, lemon dropping and asymmetric pressure on small hospitals and safety-net institutions. There remain several aspects of TEAM that could limit access to care and aggravate healthcare disparities. Some of these behaviors could result in implicit or explicit undertreatment, restricted access to care and worsened healthcare segregation with negative feedback loops that continue to syphon resources from smaller hospitals and safety-net hospitals resulting in deterioration in the quality of care and general health of the already vulnerable populations these facilities serve.

过去,许多医疗改革努力被吹捧为一种从根本上减少医疗保健差距的手段。在这个领域,几乎没有人表现出任何明显的功效。人们有理由担心,医疗保险的转变插曲责任模型(TEAM)的阴谋也可能对医疗服务的获取和提供产生意想不到的影响,可能会加剧种族和少数民族以及其他弱势群体之间存在的差距。由于TEAM尚未实施,本综述旨在预测该项目可能引发的潜在缺陷和行为,否则可能导致脊柱融合护理中医疗保健差距的恶化。我们对可能受TEAM影响的机制和行为进行了叙述性回顾和预测,这些机制和行为可能导致医疗差距恶化和/或弱势群体获得医疗服务的机会减少。这些是根据其他医疗改革工作的出版经验得出的,包括卓越中心、捆绑支付计划、负责任的医疗组织和关节置换综合护理。根据先前公布的类似医疗改革举措的经验,我们认为,在几个领域,TEAM可能会加剧或恶化现有的医疗保健差距。其中包括获得护理、治疗不足和保健隔离等领域,以及拣樱桃、掉柠檬等不良行为,以及对小医院和安全网机构的不对称压力。工作队仍有几个方面可能限制获得保健和加剧保健差距。其中一些行为可能导致隐性或显性的治疗不足、获得护理的机会受到限制和医疗隔离加剧,并形成负反馈循环,继续从较小的医院和安全网医院吸取资源,导致这些设施所服务的本已脆弱人群的护理质量和总体健康状况恶化。
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引用次数: 0
Is more better? Multicenter analysis of the incidence and mechanisms of multiple pelvic fixation failure in adult spinal deformity surgery. 越多越好吗?成人脊柱畸形手术中多次骨盆固定失败的发生率和机制的多中心分析。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.spinee.2025.12.013
Pawel P Jankowski, Paritash Tahmasebpour, Spencer Matthews, Peter G Passias, Christopher Martin, Jonathan Sembrano, Christopher Kleck, David Ou-Yang, Jack Strobeck, Yashar Javidan, Kelsey Hideshima, Hania Shahzad, Kari Odland, Christopher Shaffrey, Bishop Anyiwe, David Polly
<p><strong>Background context: </strong>High mechanical stress at the lumbosacral junction (LSJ) contributes to elevated failure rates in long-segment adult spinal deformity (ASD) fusions. To enhance fusion across the LSJ and preserve correction after ASD surgery, pelvic fixation has become a critical component of surgical constructs. However, conventional techniques that use a single point of fixation per side remain prone to implant failure. Biomechanical studies indicate that multiple-point pelvic fixation (MPF) may improve load distribution and construct stability, yet supporting clinical evidence remains limited.</p><p><strong>Purpose: </strong>The purpose of this study was to assess the incidence, mechanisms, and potential protective strategies for pelvic fixation failure (PFF) utilizing multiple pelvic fixation (MPF) constructs in adult spinal deformity (ASD) surgery.</p><p><strong>Study design/setting: </strong>Multicenter retrospective-prospective cohort study conducted across four tertiary spine centers from 2010 to 2024.</p><p><strong>Patient sample: </strong>229 ASD patients (age ≥ 18 years, minimum of five instrumented levels) with pelvic fixation (S2-alar-iliac [S2AI] and/or iliac screws) with a minimum 1-year follow-up, consecutively collected (2010-2024). MPF was defined as having more than two pelvic fixation points per patient, with at least one sacral-alar-iliac (SAI) screw per side.</p><p><strong>Outcome measures: </strong>The primary endpoint was establishing the incidence of pelvic fixation failure requiring reoperation in MPF constructs. The secondary endpoint was to determine the mechanisms underlying PFF in MPF constructs.</p><p><strong>Methods: </strong>PFF endpoints included implant failure requiring reoperation (RR), all-modality failure RR, all-modality failure not requiring reoperation (NRR), screw loosening (NRR), and rod breakage. Patient information including demographic data and health history (age, sex, BMI), instrumented levels (IL), three-column osteotomy (3CO), interbody fusion (IBF), screw (iliac, S2AI, length, diameter), rod (diameter, material), rod pattern (number crossing lumbopelvic junction), pre- and post-surgery (pelvic incidence, pelvic tilt, T1 pelvic angle (TPA), PI-LL, and sacral slope parameters were collected. Failure rates were compared with single-fixation benchmarks from Eastlack et al. (2022) using one-sample z-tests for proportions. Radiographic parameters and implant characteristics were analyzed between the failure and non-failure groups.</p><p><strong>Results: </strong>From the 229 patients analyzed (52.4% female, mean age 67.2, mean IL 11.3, 3CO 27.9%, L5-S1 IBF 45.8%, L4-L5 IBF 34.1%) 3.1% (n = 7) experienced PFF requiring reoperation after 1 year. Mean screws per patient were 3.6 (S2AI (77.7%). MPF implants had a mean length of 88.7mm and a mean diameter of 9.53mm. Mean rods across the LS junction were 3.37 with 50.7% cobalt chrome. PFF due to mechanical failure requiring reoperation
背景背景:腰骶交界处(LSJ)的高机械应力导致长节段成人脊柱畸形(ASD)融合失败率升高。为了增强整个LSJ的融合并保持ASD手术后的矫正,骨盆固定已成为手术装置的关键组成部分。然而,传统的每侧单点固定技术仍然容易导致种植体失败。生物力学研究表明多点骨盆固定(MPF)可以改善负荷分布和结构稳定性,但支持的临床证据仍然有限。目的:本研究的目的是评估在成人脊柱畸形(ASD)手术中使用多个骨盆固定(MPF)结构的骨盆固定失败(PFF)的发生率、机制和潜在的保护策略。研究设计/设置:2010年至2024年在四个三级脊柱中心进行的多中心回顾性前瞻性队列研究。患者样本:229例ASD患者(年龄≥18岁,至少有5个固定节段),骨盆固定(S2-alar-iliac [S2AI]和/或髂螺钉),至少随访1年,连续收集(2010-2024)。MPF被定义为每个患者有两个以上的骨盆固定点,每侧至少有一个骶翼髂(SAI)螺钉。结果测量:主要终点是确定在MPF装置中需要再次手术的骨盆固定失败的发生率。次要终点是确定MPF结构中PFF的潜在机制。方法:PFF终点包括需要再手术的种植体失败(RR)、全模态失败(RR)、不需要再手术的全模态失败(NRR)、螺钉松动(NRR)和棒断裂。收集患者信息,包括人口统计数据和病史(年龄、性别、BMI)、固定水平(IL)、三柱截骨术(3CO)、体间融合术(IBF)、螺钉(髂骨、S2AI、长度、直径)、棒(直径、材料)、棒型(穿过腰骨盆连接处的数量)、术前和术后(骨盆发生率、骨盆倾斜、T1骨盆角(TPA)、PI-LL和骶骨坡度参数。使用单样本比例z检验比较了Eastlack等人(2022)的单固定基准的故障率。对失败组和非失败组的x线摄影参数和种植体特征进行分析。结果:229例患者(女性52.4%,平均年龄67.2岁,平均IL 11.3, 3CO 27.9%, L5-S1 IBF 45.8%, L4-L5 IBF 34.1%) 3.1% (n = 7)在1年后发生PFF需要再次手术。每位患者平均使用3.6枚螺钉(S2AI)(77.7%)。MPF种植体的平均长度为88.7mm,平均直径为9.53mm。LS路口的平均杆数为3.37,钴铬含量为50.7%。1年后因机械故障需要再次手术的PFF为2.2% (n = 5)。无需再手术的强积金率为6.6% (n = 15)。其他失效机制包括杆断裂(2.2%;n = 5)[2(0.9%)需要再次手术]和螺钉松动(5.2%;n = 12)。手术失败往往与术前更大的畸形有关,术前骨盆倾斜(29.6°vs. 26.2°)和TPA(30.4°vs. 27.4°)以及较短的螺钉长度(86.7 mm vs. 88.8mm)就是证据。结论:多点骨盆固定可降低长节段ASD手术中PFF的风险。与使用单点或有限点固定策略的多中心报道相比,观察到的失败率,包括翻修和未翻修的病例,使用多个盆腔锚固定的结构更低。跨多个固定点的负荷分布增强了结构的耐久性,为长节段融合提供了更稳定的基础,减少了种植体失败和翻修手术的需要。
{"title":"Is more better? Multicenter analysis of the incidence and mechanisms of multiple pelvic fixation failure in adult spinal deformity surgery.","authors":"Pawel P Jankowski, Paritash Tahmasebpour, Spencer Matthews, Peter G Passias, Christopher Martin, Jonathan Sembrano, Christopher Kleck, David Ou-Yang, Jack Strobeck, Yashar Javidan, Kelsey Hideshima, Hania Shahzad, Kari Odland, Christopher Shaffrey, Bishop Anyiwe, David Polly","doi":"10.1016/j.spinee.2025.12.013","DOIUrl":"https://doi.org/10.1016/j.spinee.2025.12.013","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background context: &lt;/strong&gt;High mechanical stress at the lumbosacral junction (LSJ) contributes to elevated failure rates in long-segment adult spinal deformity (ASD) fusions. To enhance fusion across the LSJ and preserve correction after ASD surgery, pelvic fixation has become a critical component of surgical constructs. However, conventional techniques that use a single point of fixation per side remain prone to implant failure. Biomechanical studies indicate that multiple-point pelvic fixation (MPF) may improve load distribution and construct stability, yet supporting clinical evidence remains limited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The purpose of this study was to assess the incidence, mechanisms, and potential protective strategies for pelvic fixation failure (PFF) utilizing multiple pelvic fixation (MPF) constructs in adult spinal deformity (ASD) surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design/setting: &lt;/strong&gt;Multicenter retrospective-prospective cohort study conducted across four tertiary spine centers from 2010 to 2024.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patient sample: &lt;/strong&gt;229 ASD patients (age ≥ 18 years, minimum of five instrumented levels) with pelvic fixation (S2-alar-iliac [S2AI] and/or iliac screws) with a minimum 1-year follow-up, consecutively collected (2010-2024). MPF was defined as having more than two pelvic fixation points per patient, with at least one sacral-alar-iliac (SAI) screw per side.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome measures: &lt;/strong&gt;The primary endpoint was establishing the incidence of pelvic fixation failure requiring reoperation in MPF constructs. The secondary endpoint was to determine the mechanisms underlying PFF in MPF constructs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;PFF endpoints included implant failure requiring reoperation (RR), all-modality failure RR, all-modality failure not requiring reoperation (NRR), screw loosening (NRR), and rod breakage. Patient information including demographic data and health history (age, sex, BMI), instrumented levels (IL), three-column osteotomy (3CO), interbody fusion (IBF), screw (iliac, S2AI, length, diameter), rod (diameter, material), rod pattern (number crossing lumbopelvic junction), pre- and post-surgery (pelvic incidence, pelvic tilt, T1 pelvic angle (TPA), PI-LL, and sacral slope parameters were collected. Failure rates were compared with single-fixation benchmarks from Eastlack et al. (2022) using one-sample z-tests for proportions. Radiographic parameters and implant characteristics were analyzed between the failure and non-failure groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From the 229 patients analyzed (52.4% female, mean age 67.2, mean IL 11.3, 3CO 27.9%, L5-S1 IBF 45.8%, L4-L5 IBF 34.1%) 3.1% (n = 7) experienced PFF requiring reoperation after 1 year. Mean screws per patient were 3.6 (S2AI (77.7%). MPF implants had a mean length of 88.7mm and a mean diameter of 9.53mm. Mean rods across the LS junction were 3.37 with 50.7% cobalt chrome. PFF due to mechanical failure requiring reoperation","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-like peptide-1 receptor agonist use and perioperative outcomes after anterior cervical discectomy and fusion: a propensity-matched cohort study. GLP-1受体激动剂的使用和ACDF术后围手术期结果:一项倾向匹配的队列研究。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.spinee.2025.12.019
Kevin Y Heo, Stephen R Barchick, Aubrie M Sowa, Myra Chao, Prashant V Rajan, Brian C Goh, Sangwook T Yoon
<p><strong>Background context: </strong>Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a powerful treatment adjunct for type-2 diabetes mellitus (T2DM) and obesity by delaying gastric emptying and promoting early satiety. Previous studies have shown decreased complications associated with GLP-1 agonists after total hip and knee arthroplasty; however, the effects of GLP-1 agonists on outcomes following anterior cervical discectomy and fusion (ACDF) are not well known.</p><p><strong>Purpose: </strong>This study aimed to compare the risk of complications after ACDF in patients with T2DM and obesity (body mass index >30) who were on GLP-1 agonists with comparable patients who were not on these medications. We hypothesized that these medications reduce overall complications when compared to a matched cohort of diabetic and/or obese patients, but may place patients who undergo anterior cervical surgery at increased risk of aspiration due to the delayed gastric emptying.</p><p><strong>Study design/setting: </strong>Retrospective cohort study.</p><p><strong>Patient sample: </strong>Adult patients with T2DM and/or obesity undergoing single or two-level ACDF between 2015 and 2022.</p><p><strong>Outcome measures: </strong>Outcomes of the study included the incidence of 90-day and 1-year postoperative complications, including surgical site infections, wound dehiscence, hematoma, dysphagia, pulmonary aspiration, deep vein thrombosis or pulmonary embolism (DVT/PE), acute kidney injury, sepsis, hospital readmissions, extended hospital length of stay (≥3 days), and pseudoarthrosis or nonunion.</p><p><strong>Methods: </strong>Adult patients with T2DM and/or obesity undergoing single or two-level primary ACDF between 2015 and 2022 were reviewed utilizing an administrative claims database. Patients who had concurrent posterior decompression and fusion procedures were excluded. Propensity score matching was employed at a 1:1 ratio to match patients using GLP-1 agonists 6 months before and after surgery (treatment) to those who did not (control). Patients were matched on age, sex, Elixhauser comorbidity index, insulin-dependence and diabetic complications, presence of other diabetic medications, morbid obesity (body mass index >40), and active smoking status. Multivariable logistic regressions were performed to examine 90-day and 1-year outcomes between groups.</p><p><strong>Results: </strong>In total, 20,941 patients with T2DM and/or obesity were queried from the database. 1,598 patients were included in both the treatment group and control group after propensity-score matching. There were no differences in rates of postoperative pulmonary aspiration in patients utilizing GLP-1 agonists compared to those who were not (0.81% vs. 1.25%, p=.39). There were decreased rates of 90-day DVT/PE (0.44% vs. 0.94%, p=.04), and acute kidney injury (0.94% vs. 1.69%, p=.04) in the treatment group when compared to the control group. GLP-1 agonist use was associat
背景:胰高血糖素样肽-1 (GLP-1)受体激动剂已成为2型糖尿病(T2DM)和肥胖的有效治疗辅助药物,可延迟胃排空和促进早期饱腹感。先前的研究表明,GLP-1激动剂可减少全髋关节和膝关节置换术后的并发症;然而,GLP-1激动剂对前路颈椎椎间盘切除术和融合(ACDF)后预后的影响尚不清楚。目的:本研究旨在比较使用GLP-1激动剂的2型糖尿病和肥胖(BMI为bbbb30)患者与未使用这些药物的患者ACDF后并发症的风险。我们假设,与匹配队列的糖尿病和/或肥胖患者相比,这些药物减少了总体并发症,但可能使接受颈椎前路手术的患者由于胃排空延迟而增加误吸的风险。研究设计/设置:回顾性队列研究患者样本:2015年至2022年间接受单或双水平ACDF治疗的成年T2DM和/或肥胖患者研究结果包括术后90天和1年并发症的发生率,包括手术部位感染、伤口裂开、血肿、吞咽困难、肺误吸、深静脉血栓形成或肺栓塞(DVT/PE)、急性肾损伤(AKI)、败血症、再入院、延长住院时间(≥3天)、假关节或不愈合。方法:利用行政索赔数据库对2015年至2022年间接受单级或双级原发性ACDF的成年T2DM和/或肥胖患者进行回顾性研究。同时进行后路减压和融合手术的患者被排除在外。倾向评分匹配采用1:1的比例来匹配术前和术后6个月使用GLP-1激动剂的患者(治疗)和未使用GLP-1激动剂的患者(对照组)。患者的年龄、性别、依力克豪瑟合并症指数(ECI)、胰岛素依赖和糖尿病并发症、是否存在其他糖尿病药物、病态肥胖(BMI bbb40)和积极吸烟状况进行匹配。采用多变量logistic回归检验两组间90天和1年的预后。结果:共从数据库中查询了20,941例T2DM和/或肥胖患者。经倾向评分匹配后,治疗组和对照组各入组1598例。与未使用GLP-1激动剂的患者相比,使用GLP-1激动剂的患者术后肺误吸率无差异(0.81%对1.25%,P=0.39)。治疗组90天DVT/PE发生率(0.44%比0.94%,P=0.04)和急性肾损伤发生率(0.94%比1.69%,P=0.04)均低于对照组。GLP-1激动剂的使用与延长住院时间的减少率相关(15.96%对18.65%,P=0.04)。ACDF后1年,DVT/PE发生率(1.56%对2.00%,P=0.36)或假关节发生率(2.82%对3.25%,P=0.50)无差异。结论:在这项研究中,GLP-1激动剂在没有增加单级或双级ACDF患者误吸风险的情况下显示出良好的结果。除了减少术后医学并发症外,这些药物也没有增加术后肺误吸或1年假关节的风险。总的来说,虽然GLP-1激动剂提供包括血糖控制和体重减轻在内的益处,但需要更多的数据来描述GLP-1激动剂对ACDF后临床结果的真正影响。
{"title":"Glucagon-like peptide-1 receptor agonist use and perioperative outcomes after anterior cervical discectomy and fusion: a propensity-matched cohort study.","authors":"Kevin Y Heo, Stephen R Barchick, Aubrie M Sowa, Myra Chao, Prashant V Rajan, Brian C Goh, Sangwook T Yoon","doi":"10.1016/j.spinee.2025.12.019","DOIUrl":"10.1016/j.spinee.2025.12.019","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background context: &lt;/strong&gt;Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a powerful treatment adjunct for type-2 diabetes mellitus (T2DM) and obesity by delaying gastric emptying and promoting early satiety. Previous studies have shown decreased complications associated with GLP-1 agonists after total hip and knee arthroplasty; however, the effects of GLP-1 agonists on outcomes following anterior cervical discectomy and fusion (ACDF) are not well known.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;This study aimed to compare the risk of complications after ACDF in patients with T2DM and obesity (body mass index &gt;30) who were on GLP-1 agonists with comparable patients who were not on these medications. We hypothesized that these medications reduce overall complications when compared to a matched cohort of diabetic and/or obese patients, but may place patients who undergo anterior cervical surgery at increased risk of aspiration due to the delayed gastric emptying.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design/setting: &lt;/strong&gt;Retrospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patient sample: &lt;/strong&gt;Adult patients with T2DM and/or obesity undergoing single or two-level ACDF between 2015 and 2022.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome measures: &lt;/strong&gt;Outcomes of the study included the incidence of 90-day and 1-year postoperative complications, including surgical site infections, wound dehiscence, hematoma, dysphagia, pulmonary aspiration, deep vein thrombosis or pulmonary embolism (DVT/PE), acute kidney injury, sepsis, hospital readmissions, extended hospital length of stay (≥3 days), and pseudoarthrosis or nonunion.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Adult patients with T2DM and/or obesity undergoing single or two-level primary ACDF between 2015 and 2022 were reviewed utilizing an administrative claims database. Patients who had concurrent posterior decompression and fusion procedures were excluded. Propensity score matching was employed at a 1:1 ratio to match patients using GLP-1 agonists 6 months before and after surgery (treatment) to those who did not (control). Patients were matched on age, sex, Elixhauser comorbidity index, insulin-dependence and diabetic complications, presence of other diabetic medications, morbid obesity (body mass index &gt;40), and active smoking status. Multivariable logistic regressions were performed to examine 90-day and 1-year outcomes between groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In total, 20,941 patients with T2DM and/or obesity were queried from the database. 1,598 patients were included in both the treatment group and control group after propensity-score matching. There were no differences in rates of postoperative pulmonary aspiration in patients utilizing GLP-1 agonists compared to those who were not (0.81% vs. 1.25%, p=.39). There were decreased rates of 90-day DVT/PE (0.44% vs. 0.94%, p=.04), and acute kidney injury (0.94% vs. 1.69%, p=.04) in the treatment group when compared to the control group. GLP-1 agonist use was associat","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smartphone-recorded real-world physical performance compared to standardized capacity-based outcome in patients with sciatica. 智能手机记录的真实身体表现与坐骨神经痛患者标准化的基于能力的结果相比较。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.spinee.2025.12.017
Erdem Yurtsever, Linda Bättig, Raphael Gmeiner, Martin N Stienen, Ulf C Schneider, Ondra Petr, Nicolai Maldaner, Michal Ziga

Background context: Degenerative lumbar disorders (DLD) accompanied by sciatica frequently impair mobility and reduce functional capacity. Although patient-reported outcome measures (PROMs) and standardized tests are widely applied, real-world indicators of physical activity remain insufficiently examined. Modern smartphones can continuously record step counts, offering an accessible means of assessing daily movement patterns. However, the reliability of this approach in individuals with DLD-related sciatica has not yet been clearly determined.

Purpose: This study aimed to assess whether smartphone-derived daily step count accurately reflects real-life physical performance in patients with sciatica secondary to DLD and to explore how it correlates with established subjective and objective outcome measures.

Study design: Prospective observational cohort study PATIENT SAMPLE: 50 patients with sciatica secondary to DLD scheduled for microsurgery OUTCOME MEASURES: Physical performance was determined using smartphone-based daily step count, physical capacity by the 6-minute Walking Test application (6WT-app) and subjective disability by a set of paper-based patient-reported outcome measures (PROMs) prior to microsurgery.

Methods: Participants' step counts, 6WT results, and PROMs (COMI-Back, ODI) were analyzed. Activity data were standardized using age- and sex-specific reference values (z-scores) to categorize impairment levels. Correlations among all measures were calculated using Spearman coefficients.

Results: Mean daily step count was 4602 steps (SD 1074, z-score -1.1), and mean 6WT distance was 398 meters (SD 88, z-score -1.4). Most patients (58%) showed moderate impairment in both metrics. Step count correlated strongly with 6WT (r = 0.70) and moderately with ODI (r = -0.63) and COMI-Back (r = -0.65), with weaker correlations for back (r = -0.50) and leg pain (r = -0.30). Stratification revealed small discrepancies between physical capacity and real-life performance, suggesting that both variables might capture distinct aspects of disability CONCLUSION: Smartphone-based step counting provides a valid, objective indicator of physical performance in sciatica patients with DLD. Its association with both functional test results and self-reported disability suggests that smartphone data can serve as a practical complement to existing evaluation methods.

背景:伴有坐骨神经痛的退行性腰椎疾病(DLD)经常损害活动能力和降低功能。尽管患者报告的结果测量(PROMs)和标准化测试被广泛应用,但现实世界的身体活动指标仍然没有得到充分的检验。现代智能手机可以持续记录步数,为评估日常运动模式提供了一种方便的方法。然而,这种入路在dld相关坐骨神经痛患者中的可靠性尚未明确确定。目的:本研究旨在评估智能手机衍生的每日步数是否准确反映DLD继发坐骨神经痛患者的真实身体表现,并探讨其与既定主观和客观结果测量的相关性。研究设计:前瞻性观察队列研究患者样本:50例计划进行显微手术的DLD继发性坐骨神经痛患者。结果测量:通过基于智能手机的每日步数来确定身体表现,通过6分钟步行测试应用程序(6WT-app)来确定身体能力,通过显微手术前一组基于纸张的患者报告结果测量(PROMs)来确定主观残疾。方法:对参与者的步数、6WT结果和PROMs (COMI-Back, ODI)进行分析。使用年龄和性别特定的参考值(z-score)对活动数据进行标准化,以分类损伤水平。使用Spearman系数计算所有测量之间的相关性。结果:平均每日步数为4602步(SD 1074, z-score -1.1),平均6WT距离为398米(SD 88, z-score -1.4)。大多数患者(58%)在这两个指标上都表现出中度损伤。步数相关与6 wt (r = 0.70)和适度ODI (r = -0.63)和COMI-Back (r = -0.65),较弱的相关性为(-0.50 r = )和腿部疼痛(r = -0.30)。分层显示,身体能力和现实生活表现之间存在微小差异,这表明这两个变量可能反映残疾的不同方面。结论:基于智能手机的步数计算为DLD坐骨神经痛患者的身体表现提供了一个有效、客观的指标。它与功能测试结果和自我报告的残疾之间的联系表明,智能手机数据可以作为现有评估方法的实用补充。
{"title":"Smartphone-recorded real-world physical performance compared to standardized capacity-based outcome in patients with sciatica.","authors":"Erdem Yurtsever, Linda Bättig, Raphael Gmeiner, Martin N Stienen, Ulf C Schneider, Ondra Petr, Nicolai Maldaner, Michal Ziga","doi":"10.1016/j.spinee.2025.12.017","DOIUrl":"10.1016/j.spinee.2025.12.017","url":null,"abstract":"<p><strong>Background context: </strong>Degenerative lumbar disorders (DLD) accompanied by sciatica frequently impair mobility and reduce functional capacity. Although patient-reported outcome measures (PROMs) and standardized tests are widely applied, real-world indicators of physical activity remain insufficiently examined. Modern smartphones can continuously record step counts, offering an accessible means of assessing daily movement patterns. However, the reliability of this approach in individuals with DLD-related sciatica has not yet been clearly determined.</p><p><strong>Purpose: </strong>This study aimed to assess whether smartphone-derived daily step count accurately reflects real-life physical performance in patients with sciatica secondary to DLD and to explore how it correlates with established subjective and objective outcome measures.</p><p><strong>Study design: </strong>Prospective observational cohort study PATIENT SAMPLE: 50 patients with sciatica secondary to DLD scheduled for microsurgery OUTCOME MEASURES: Physical performance was determined using smartphone-based daily step count, physical capacity by the 6-minute Walking Test application (6WT-app) and subjective disability by a set of paper-based patient-reported outcome measures (PROMs) prior to microsurgery.</p><p><strong>Methods: </strong>Participants' step counts, 6WT results, and PROMs (COMI-Back, ODI) were analyzed. Activity data were standardized using age- and sex-specific reference values (z-scores) to categorize impairment levels. Correlations among all measures were calculated using Spearman coefficients.</p><p><strong>Results: </strong>Mean daily step count was 4602 steps (SD 1074, z-score -1.1), and mean 6WT distance was 398 meters (SD 88, z-score -1.4). Most patients (58%) showed moderate impairment in both metrics. Step count correlated strongly with 6WT (r = 0.70) and moderately with ODI (r = -0.63) and COMI-Back (r = -0.65), with weaker correlations for back (r = -0.50) and leg pain (r = -0.30). Stratification revealed small discrepancies between physical capacity and real-life performance, suggesting that both variables might capture distinct aspects of disability CONCLUSION: Smartphone-based step counting provides a valid, objective indicator of physical performance in sciatica patients with DLD. Its association with both functional test results and self-reported disability suggests that smartphone data can serve as a practical complement to existing evaluation methods.</p>","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower extremity deep sensory disturbance as a risk factor for postlaminoplasty kyphosis in patients with cervical ossification of the posterior longitudinal ligament. 下肢深度感觉障碍是颈椎后纵韧带骨化患者椎板成形术后脊柱后凸的危险因素。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-28 DOI: 10.1016/j.spinee.2025.12.010
Tomoya Kanto, Haruki Ueda, Takuya Iimura, Tsuyoshi Sorimachi, Hiroshi Moridaira, Shotaro Fukada, Hiroyuki Hasebe, Miki Komatsu, Satoshi Inami, Satoshi Takada, Masahiro Kanayama, Itaru Oda, Katsuhisa Yamada, Norimasa Iwasaki, Hiroshi Taneichi, Masahiko Takahata

Background context: Cervical laminoplasty (LMP) is a standard surgical procedure for treating ossification of the posterior longitudinal ligament (OPLL). However, postlaminoplasty kyphosis (PLK) remains an unresolved problem. Although a restricted cervical extension range of motions (ROM) and sagittal imbalance have been reported as risk factors for PLK, these factors do not fully explain its occurrence. Deep sensory disturbance (DSD) of the lower extremities has been reported as a cause of habitual neck flexion while walking or ascending stairs, as patients visually compensate for impaired proprioception; however, its association with PLK has not been clearly established.

Purpose: To investigate whether lower extremity DSD is associated with an increased risk of PLK in patients with cervical OPLL.

Study design/setting: Retrospective multicenter observational study.

Patient sample: A total of 190 patients with radiographically and clinically diagnosed cervical OPLL who underwent cervical LMP involving more than 3 levels between 2008 and 2023 at 2 university hospitals and 5 general hospitals in Japan.

Outcome measures: Postoperative kyphosis progression was defined as a decrease of ≥9° in the C2-7 lordotic angle on lateral radiographs. Risk factors were assessed using demographic, clinical, and radiographic variables, including cervical ROM, sagittal vertical axis (SVA), and the presence of DSD.

Methods: Radiographic measurements and clinical data were retrospectively reviewed. Patients were classified into PLK and non-PLK groups based on changes in the C2-7 angle. Multivariate logistic regression analysis was performed to identify independent risk factors for PLK.

Results: Of the 190 patients, 50 (26.3%) exhibited kyphosis progression. DSD was significantly more prevalent in the PLK group. Multivariate analysis identified DSD, decreased preoperative cervical extension ROM, and increased preoperative C2-7 SVA as independent risk factors for PLK. Patients with DSD demonstrated greater preoperative C2-7 SVA and reduced cervical extension ROM.

Conclusions: DSD in the lower extremities is a significant independent risk factor for PLK in patients with cervical OPLL, likely due to habitual downward gaze for visual compensation during walking. These findings underscore the importance of considering DSD in postoperative rehabilitation strategies aimed at preventing PLK.

背景背景:颈椎椎板成形术(LMP)是治疗后纵韧带骨化(OPLL)的标准手术方法。然而,椎板成形术后的后凸(PLK)仍然是一个未解决的问题。尽管有报道称颈椎活动范围受限和矢状面不平衡是PLK的危险因素,但这些因素并不能完全解释其发生。据报道,下肢深度感觉障碍(DSD)是行走或上楼梯时习惯性颈部屈曲的原因,因为患者在视觉上补偿本体感觉受损;然而,它与PLK的关系尚未得到明确确定。目的:探讨颈椎OPLL患者下肢DSD是否与PLK风险增加相关。研究设计/设置:回顾性多中心观察性研究。患者样本:2008年至2023年间,日本两所大学医院和五所综合医院共190例经影像学和临床诊断为颈椎OPLL的患者接受了三个以上级别的颈椎LMP。结果测量:。术后后凸进展定义为侧位片上C2-7前凸角减小≥9°。使用人口统计学、临床和放射学变量评估危险因素,包括颈椎ROM、矢状垂直轴(SVA)和DSD的存在。方法:回顾性分析影像学资料和临床资料。根据C2-7角度的变化将患者分为PLK组和非PLK组。多因素logistic回归分析确定PLK的独立危险因素。结果:190例患者中,50例(26.3%)出现后凸进展。DSD在PLK组中更为普遍。多因素分析发现,DSD、术前颈椎伸展ROM降低、术前C2-7 SVA升高是PLK的独立危险因素。DSD患者在术前表现出较大的C2-7 SVA和颈椎伸直rom。结论:下肢DSD是颈椎OPLL患者PLK的重要独立危险因素,可能是由于行走时习惯性向下凝视以进行视觉补偿。这些发现强调了在预防PLK的术后康复策略中考虑DSD的重要性。
{"title":"Lower extremity deep sensory disturbance as a risk factor for postlaminoplasty kyphosis in patients with cervical ossification of the posterior longitudinal ligament.","authors":"Tomoya Kanto, Haruki Ueda, Takuya Iimura, Tsuyoshi Sorimachi, Hiroshi Moridaira, Shotaro Fukada, Hiroyuki Hasebe, Miki Komatsu, Satoshi Inami, Satoshi Takada, Masahiro Kanayama, Itaru Oda, Katsuhisa Yamada, Norimasa Iwasaki, Hiroshi Taneichi, Masahiko Takahata","doi":"10.1016/j.spinee.2025.12.010","DOIUrl":"10.1016/j.spinee.2025.12.010","url":null,"abstract":"<p><strong>Background context: </strong>Cervical laminoplasty (LMP) is a standard surgical procedure for treating ossification of the posterior longitudinal ligament (OPLL). However, postlaminoplasty kyphosis (PLK) remains an unresolved problem. Although a restricted cervical extension range of motions (ROM) and sagittal imbalance have been reported as risk factors for PLK, these factors do not fully explain its occurrence. Deep sensory disturbance (DSD) of the lower extremities has been reported as a cause of habitual neck flexion while walking or ascending stairs, as patients visually compensate for impaired proprioception; however, its association with PLK has not been clearly established.</p><p><strong>Purpose: </strong>To investigate whether lower extremity DSD is associated with an increased risk of PLK in patients with cervical OPLL.</p><p><strong>Study design/setting: </strong>Retrospective multicenter observational study.</p><p><strong>Patient sample: </strong>A total of 190 patients with radiographically and clinically diagnosed cervical OPLL who underwent cervical LMP involving more than 3 levels between 2008 and 2023 at 2 university hospitals and 5 general hospitals in Japan.</p><p><strong>Outcome measures: </strong>Postoperative kyphosis progression was defined as a decrease of ≥9° in the C2-7 lordotic angle on lateral radiographs. Risk factors were assessed using demographic, clinical, and radiographic variables, including cervical ROM, sagittal vertical axis (SVA), and the presence of DSD.</p><p><strong>Methods: </strong>Radiographic measurements and clinical data were retrospectively reviewed. Patients were classified into PLK and non-PLK groups based on changes in the C2-7 angle. Multivariate logistic regression analysis was performed to identify independent risk factors for PLK.</p><p><strong>Results: </strong>Of the 190 patients, 50 (26.3%) exhibited kyphosis progression. DSD was significantly more prevalent in the PLK group. Multivariate analysis identified DSD, decreased preoperative cervical extension ROM, and increased preoperative C2-7 SVA as independent risk factors for PLK. Patients with DSD demonstrated greater preoperative C2-7 SVA and reduced cervical extension ROM.</p><p><strong>Conclusions: </strong>DSD in the lower extremities is a significant independent risk factor for PLK in patients with cervical OPLL, likely due to habitual downward gaze for visual compensation during walking. These findings underscore the importance of considering DSD in postoperative rehabilitation strategies aimed at preventing PLK.</p>","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to 'Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: risk factors associated with this "never event"' by Anthony E. Seddio et al' [The Spine Journal 25/5 (2025) 911-920]. Anthony E. Seddio等人的“颈前路椎间盘切除术和融合术患者围手术期住院患者跌倒呈上升趋势:与此“从未发生过的事件”相关的危险因素”[the Spine Journal 25/5(2025) 911-920]。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-25 DOI: 10.1016/j.spinee.2025.11.005
Anthony E Seddio, Sahir S Jabbouri, Michael J Gouzoulis, Rajiv S Vasudevan, Scott J Halperin, Arya G Varthi, Daniel R Rubio, Jonathan N Grauer
{"title":"Erratum to 'Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: risk factors associated with this \"never event\"' by Anthony E. Seddio et al' [The Spine Journal 25/5 (2025) 911-920].","authors":"Anthony E Seddio, Sahir S Jabbouri, Michael J Gouzoulis, Rajiv S Vasudevan, Scott J Halperin, Arya G Varthi, Daniel R Rubio, Jonathan N Grauer","doi":"10.1016/j.spinee.2025.11.005","DOIUrl":"https://doi.org/10.1016/j.spinee.2025.11.005","url":null,"abstract":"","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Medicaid, Medicare, and Private Insurance on Access to Orthopaedic Surgeons of the Spine: A National Mystery Caller Study. 医疗补助、医疗保险和私人保险对获得脊柱整形外科医生的影响:一项全国神秘来电者研究。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-22 DOI: 10.1016/j.spinee.2025.12.006
Nicholas A Felan, Evalina Burger, Dane Rg Lind, Jason P Sidrak, Daniel J Stokes, Tristan Seawalt, Ryan Tseng, Miranda Manfre, Amy Du, Jasmine Hartman, Bret Hatzinger, Christopher Hawryluk, Paul Botolin, Tyler M Muffly

Background context: Patients with Medicaid often experience reduced access to specialty care compared to those with Medicare or private insurance. Previous studies have assessed Medicaid acceptance in orthopaedic specialties; however, national-level data on access to spine surgery across different insurance types remain limited.

Purpose: To evaluate how insurance type-Medicaid, Medicare, and Blue Cross/Blue Shield (BCBS)-impacts access to fellowship-trained orthopaedic spine surgeons and appointment wait times.

Study design: Cross-sectional audit (mystery caller) study.

Patient sample: Fellowship-trained orthopaedic spine surgeons listed in the American Academy of Orthopaedic Surgeons public directory.

Outcome measures: The primary outcomes were insurance acceptance and the number of business days until the earliest new patient appointment. Secondary measures included total call time, hold time, and number of phone transfers.

Methods: From December 9-13, 2024, trained callers contacted 304 orthopaedic spine surgeon offices across 45 states using a standardized clinical vignette. Each office was called three times-once for Medicaid, once for Medicare, and once for Blue Cross/Blue Shield (BCBS)-in a randomized order, resulting in a total of 912 calls placed. Poisson mixed-effects regression was used to estimate the association between insurance type and wait times, adjusting for physician and practice characteristics.

Results: Of 304 physicians called, 192 were successfully contacted and met the inclusion criteria. Among eligible practices, 101 (52%) accepted Medicaid, 182 (95%) accepted Medicare, and 190 (99%) accepted BCBS insurance. If a physician accepted Medicaid insurance, the mean wait time for a new patient appointment was 26.6 business days (95% CI: 25.6-27.6). Patients with Medicare or BCBS insurance waited 23.1 (95% CI: 22.4-23.8) and 22.1 (95% CI: 21.5-22.7) business days for a new patient appointment, which was significantly fewer days than patients with Medicaid (IRR: 0.90 [95% CI: 0.83-0.98], p=0.01; IRR: 0.88 [95% CI: 0.81-0.94], p<0.01, respectively). Additionally, academic affiliation was associated with a 124% longer wait time (IRR: 2.24 [95% CI: 1.25-4.03], p<0.01).

Conclusion: Patients with Medicaid experienced decreased access to care and longer wait times for a new patient appointment when seeking care with an orthopaedic spine surgeon compared to patients with Medicare or BCBS insurance. Additionally, academic practice affiliation was associated with the most significant increase in wait time for a new patient appointment. The present findings highlight a critical disparity in care faced by an already vulnerable patient population and further emphasize the need for additional research to implement novel solutions.

背景:与那些有医疗保险或私人保险的患者相比,有医疗补助的患者经常经历较少的专科护理。先前的研究评估了骨科专业的医疗补助接受度;然而,关于不同保险类型的脊柱手术的国家层面数据仍然有限。目的:评估医疗补助、医疗保险和蓝十字/蓝盾(BCBS)保险类型如何影响获得奖学金培训的骨科脊柱外科医生和预约等待时间。研究设计:横断面审计(神秘来电者)研究。患者样本:在美国骨科医师学会公共目录中列出的接受过奖学金培训的骨科脊柱外科医生。结果测量:主要结果是保险接受程度和到最早的新患者预约的工作日数。次要指标包括总通话时间、保持时间和电话转接次数。方法:从2024年12月9日至13日,训练有素的来电者使用标准化的临床小短文联系了45个州的304个骨科脊柱外科医生办公室。每个办公室被按随机顺序打了三次电话——一次是医疗补助,一次是医疗保险,一次是蓝十字/蓝盾(BCBS)——总共打了912个电话。泊松混合效应回归用于估计保险类型和等待时间之间的关联,调整医生和实践特征。结果:304名受访医师中,192名成功联系,符合纳入标准。在符合条件的诊所中,101家(52%)接受了医疗补助,182家(95%)接受了医疗保险,190家(99%)接受了BCBS保险。如果医生接受医疗补助保险,新病人预约的平均等待时间为26.6个工作日(95% CI: 25.6-27.6)。医疗保险或BCBS保险患者等待新患者预约的时间分别为23.1 (95% CI: 22.4-23.8)和22.1 (95% CI: 21.5-22.7)个工作日,明显少于医疗补助患者(IRR: 0.90 [95% CI: 0.83-0.98], p=0.01;IRR: 0.88 [95% CI: 0.81-0.94],结论:与医疗保险或BCBS保险的患者相比,医疗补助患者在寻求骨科脊柱外科医生的护理时,获得护理的机会减少,等待新患者预约的时间更长。此外,学术实践隶属关系与新患者预约等待时间的显著增加有关。目前的研究结果突出了弱势患者群体在护理方面的严重差异,并进一步强调需要进一步研究以实施新的解决方案。
{"title":"Impact of Medicaid, Medicare, and Private Insurance on Access to Orthopaedic Surgeons of the Spine: A National Mystery Caller Study.","authors":"Nicholas A Felan, Evalina Burger, Dane Rg Lind, Jason P Sidrak, Daniel J Stokes, Tristan Seawalt, Ryan Tseng, Miranda Manfre, Amy Du, Jasmine Hartman, Bret Hatzinger, Christopher Hawryluk, Paul Botolin, Tyler M Muffly","doi":"10.1016/j.spinee.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.spinee.2025.12.006","url":null,"abstract":"<p><strong>Background context: </strong>Patients with Medicaid often experience reduced access to specialty care compared to those with Medicare or private insurance. Previous studies have assessed Medicaid acceptance in orthopaedic specialties; however, national-level data on access to spine surgery across different insurance types remain limited.</p><p><strong>Purpose: </strong>To evaluate how insurance type-Medicaid, Medicare, and Blue Cross/Blue Shield (BCBS)-impacts access to fellowship-trained orthopaedic spine surgeons and appointment wait times.</p><p><strong>Study design: </strong>Cross-sectional audit (mystery caller) study.</p><p><strong>Patient sample: </strong>Fellowship-trained orthopaedic spine surgeons listed in the American Academy of Orthopaedic Surgeons public directory.</p><p><strong>Outcome measures: </strong>The primary outcomes were insurance acceptance and the number of business days until the earliest new patient appointment. Secondary measures included total call time, hold time, and number of phone transfers.</p><p><strong>Methods: </strong>From December 9-13, 2024, trained callers contacted 304 orthopaedic spine surgeon offices across 45 states using a standardized clinical vignette. Each office was called three times-once for Medicaid, once for Medicare, and once for Blue Cross/Blue Shield (BCBS)-in a randomized order, resulting in a total of 912 calls placed. Poisson mixed-effects regression was used to estimate the association between insurance type and wait times, adjusting for physician and practice characteristics.</p><p><strong>Results: </strong>Of 304 physicians called, 192 were successfully contacted and met the inclusion criteria. Among eligible practices, 101 (52%) accepted Medicaid, 182 (95%) accepted Medicare, and 190 (99%) accepted BCBS insurance. If a physician accepted Medicaid insurance, the mean wait time for a new patient appointment was 26.6 business days (95% CI: 25.6-27.6). Patients with Medicare or BCBS insurance waited 23.1 (95% CI: 22.4-23.8) and 22.1 (95% CI: 21.5-22.7) business days for a new patient appointment, which was significantly fewer days than patients with Medicaid (IRR: 0.90 [95% CI: 0.83-0.98], p=0.01; IRR: 0.88 [95% CI: 0.81-0.94], p<0.01, respectively). Additionally, academic affiliation was associated with a 124% longer wait time (IRR: 2.24 [95% CI: 1.25-4.03], p<0.01).</p><p><strong>Conclusion: </strong>Patients with Medicaid experienced decreased access to care and longer wait times for a new patient appointment when seeking care with an orthopaedic spine surgeon compared to patients with Medicare or BCBS insurance. Additionally, academic practice affiliation was associated with the most significant increase in wait time for a new patient appointment. The present findings highlight a critical disparity in care faced by an already vulnerable patient population and further emphasize the need for additional research to implement novel solutions.</p>","PeriodicalId":49484,"journal":{"name":"Spine Journal","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regenerative potential of young versus senescent rabbit adipose-derived mesenchymal stem cells and their impact on the treatment of intervertebral disc degeneration. 兔脂肪间充质干细胞的再生潜能及其对椎间盘退变治疗的影响。
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-18 DOI: 10.1016/j.spinee.2025.12.004
Eleni Mavrogonatou, Agori-Maria Korompilia, Evangeli Lampri, Vasiliki S Kavvadia, Dimitrios Kosmas, Panagiotis Kosmas, Ioannis D Gelalis, Dimitris Kletsas
<p><strong>Background context: </strong>Implantation of mesenchymal stem cells (MSCs) appears to be a promising choice for intervertebral disc (IVD) regeneration. Among MSCs, adipose-derived MSCs (ADSCs) have shown stronger differentiation ability towards a nucleus pulposus (NP)-like phenotype.</p><p><strong>Purpose: </strong>The aim of the current study was to assess the IVD regenerative potential of rabbit ADSCs (rADSCs) in vitro and in vivo. Given that preceding propagation by serial in vitro subculturing is often required to achieve high numbers of viable cells necessary for tissue regeneration applications (which could result in senescence induction), we explored the effect of senescence on rADCSs' molecular profile and function in vitro, as well as its direct effect on the final outcome of IVD tissue quality for the first time, when injected intradiscally in a rabbit model.</p><p><strong>Study design: </strong>The molecular profile of isolated young and senescent rADSCs was assessed in vitro, before their delivery into rabbit lumbar IVDs to explore differences regarding their effect on IVD tissue quality.</p><p><strong>Methods: </strong>Alcian Blue, Oil Red O and Alizarin Red S staining procedures were performed for the in vitro determination of young and senescent rADSCs' chondrogenic, adipogenic and osteogenic capacity, respectively. Assessment of rADSCs' viability, cell cycle progression and activation of selected biochemical pathways after hyperosmotic treatment was performed by the MTT assay, by flow cytometric analysis and immunofluorescence experiments for the estimation of bromodeoxyuridine (BrdU) incorporation and by western blot analysis, respectively. Senescent rADSCs were characterized in vitro based on their positive SA-β-Gal staining, inability for nuclear BrdU incorporation and catabolic transcriptional profile, the latter assessed by quantitative RT-PCR. The effect of senescence on IVD tissue quality in vivo was explored by histochemical analysis of isolated rabbit lumbar IVDs 8 weeks post-injection with young or senescent rADSCs.</p><p><strong>Results: </strong>Young rADSCs showed a high chondrogenic differentiation potential and were found to generally respond in a similar way with NP IVD cells to high osmolality in vitro, both traits being beneficial for their subsequent use in IVD regenerative applications. Senescent rADSCs displayed a complete loss of their chondrogenic potential and a highly catabolic molecular profile in vitro (up-regulation of MMP1, MMP3 and MMP13 and down-regulation of the proteoglycan aggrecan), which foreboded a negative impact on IVD tissue quality if used in a cell-based therapy. Indeed, delivery of young rADSCs into the NP of rabbit IVDs in vivo resulted in higher staining intensities of collagen type II and aggrecan, in contrast to senescent rADSCs which had the opposite effect.</p><p><strong>Conclusions: </strong>While injection of young rADSCs is beneficial for IVD regeneration in a rabbit m
背景背景:间充质干细胞(MSCs)的植入似乎是椎间盘(IVD)再生的一个有希望的选择。在间充质干细胞中,脂肪来源的间充质干细胞(ADSCs)表现出向髓核(NP)样表型分化的较强能力。目的:研究兔ADSCs (rADSCs)体外和体内体外IVD再生潜力。考虑到为了获得组织再生应用所需的大量活细胞(这可能导致衰老诱导),通常需要在体外进行连续传代培养,我们首次探索了衰老对rADCSs体外分子特征和功能的影响,以及在兔模型中皮下注射时对IVD组织质量最终结果的直接影响。研究设计:在将分离的年轻和衰老的radsc植入兔腰椎IVD之前,在体外评估其分子谱,以探讨它们对IVD组织质量的影响差异。方法:采用阿利新蓝、油红O和茜素红S染色法分别测定年轻和衰老radsc的成软骨、成脂肪和成骨能力。通过MTT法、流式细胞分析和免疫荧光实验评估高渗处理后rADSCs的活力、细胞周期进展和选定生化途径的激活,以估计溴脱氧尿苷(BrdU)的掺入,并通过western blot分析。衰老的radsc通过SA-β-Gal染色阳性、核BrdU掺入能力缺失和分解代谢转录谱进行体外表征,后者通过定量RT-PCR评估。通过对兔腰椎离体IVD注射年轻或衰老的radsc后8周的组织化学分析,探讨衰老对IVD组织质量的影响。结果:年轻的rADSCs显示出高的软骨分化潜力,并且通常以与NP IVD细胞相似的方式在体外对高渗透压作出反应,这两个特征都有利于它们随后在IVD再生应用中的应用。衰老的radsc在体外表现出完全丧失其成软骨潜能和高度分解代谢的分子谱(MMP1、MMP3和MMP13上调,蛋白多糖聚集蛋白下调),这预示着如果用于细胞治疗,对IVD组织质量会产生负面影响。事实上,将年轻的rADSCs输送到兔体内ivd的NP中,会导致II型胶原和聚集蛋白的染色强度更高,而衰老的rADSCs则具有相反的效果。结论:虽然注射年轻的rADSCs有利于兔体内模型IVD再生,但我们首次提供证据表明,衰老的rADSCs不仅在IVD治疗中无效,而且还可能使IVD组织学特征恶化。
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引用次数: 0
Onset timing and recovery patterns in segmental motor paralysis following anterior cervical spine surgery: a multicenter study of the risk factors for persistent paralysis. 颈椎前路手术后节段性运动麻痹的发病时间和恢复模式:持续性瘫痪危险因素的多中心研究
IF 4.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-15 DOI: 10.1016/j.spinee.2025.12.005
Hiroaki Onuma, Takashi Hirai, Kenichiro Sakai, Motonori Hashimoto, Hiroyuki Inose, Kentaro Yamada, Yu Matsukura, Shingo Morishita, Satoru Egawa, Jun Hashimoto, Kentaro Sakaeda, Satoshi Tamura, Ichiro Torigoe, Masaki Tomori, Kyohei Sakaki, Kazuyuki Otani, Kazuo Kusano, Tsuyoshi Yamada, Shuta Ushio, Shigeo Shindo, Yoshiyasu Arai, Toshitaka Yoshii

Background context: Segmental motor paralysis is a well-recognized complication following anterior cervical spine surgery. While risk factors have been identified, little is known about the factors that influence recovery outcomes, and there has been no systematic analysis of the relationship between onset timing and recovery patterns.

Purpose: This study aimed to investigate the clinical course of segmental motor paralysis after anterior cervical spine surgery, identify risk factors for persistent paralysis, and determine the relationship between paralysis onset timing and recovery patterns.

Study design/setting: This multicenter, retrospective cohort study was conducted at three spine centers affiliated with the Institute of Science Tokyo Group between January 2011 and March 2021.

Patient sample: Among the 1,428 patients who underwent anterior cervical procedures with complete 2-year follow-up data available, 93 patients who developed segmental motor paralysis after anterior cervical spine surgery were identified who met the inclusion criteria.

Outcome measures: Recovery was defined as a return to preoperative muscle strength, as determined by manual muscle testing. Independent risk factors for persistent paralysis were identified using multivariate logistic regression analysis. Patients were categorized into onset time groups of day 0, day 1, days 2 to 4, and day 5 or later.

Methods: Clinical and operative characteristics were compared between recovery and nonrecovery groups. Muscle strength recovery patterns were analyzed over 2 years. Risk factors for persistent paralysis were determined through univariate and multivariate analyses. No external funding was received for this study, and the authors report no study-specific conflicts of interest.

Results: At 2-year follow-up, persistent paralysis had occurred in 18 (19.4%) patients. Day 1 onset demonstrated the highest nonrecovery rate at 42.1% compared to 10.7% to 21.1% for other onset times (p=.044). Independent risk factors for persistent paralysis included a lower manual muscle testing score at onset (OR 7.38, p<.001) and a greater number of surgical levels (OR 1.86, p=.032).

Conclusions: This first systematic analysis reveals that paralysis onset on day 1 after anterior cervical spine surgery is associated with a poorer prognosis. Initial muscle weakness severity and multilevel surgery are key predictors of persistent paralysis. These findings may inform future preventive strategies.

背景背景:节段性运动麻痹是颈椎前路手术后公认的并发症。虽然已经确定了风险因素,但对影响恢复结果的因素知之甚少,并且没有对发病时间和恢复模式之间的关系进行系统分析。目的:本研究旨在探讨颈椎前路手术后节段性运动麻痹的临床病程,识别持续性麻痹的危险因素,确定麻痹发作时间与恢复模式的关系。研究设计/环境:这项多中心、回顾性队列研究于2011年1月至2021年3月在东京科学研究所附属的三个脊柱中心进行。患者样本:在1428例接受颈椎前路手术的患者中,有完整的2年随访数据,其中93例颈椎前路手术后出现节段性运动麻痹的患者符合纳入标准。结果测量:恢复被定义为术前肌肉力量的恢复,通过手工肌肉测试(MMT)确定。采用多变量logistic回归分析确定持续性瘫痪的独立危险因素。患者发病时间分为第0天、第1天、第2-4天、第5天及以后。方法:比较恢复组与未恢复组的临床及手术特点。肌肉力量恢复模式分析超过2年。通过单因素和多因素分析确定持续性瘫痪的危险因素。本研究未获得外部资助,作者报告没有研究特定的利益冲突。结果:随访2年,18例(19.4%)患者出现持续性瘫痪。第1天发病未恢复率最高,为42.1%,而其他发病时间为10.7%-21.1% (p = 0.044)。持续性瘫痪的独立危险因素包括发病时MMT评分较低(OR 7.38, p < 0.001)和较多的手术水平(OR 1.86, p = 0.032)。结论:本研究首次系统分析显示,颈椎前路手术后第1天出现瘫痪与较差的预后相关。最初的肌肉无力严重程度和多级手术是持续瘫痪的关键预测因素。这些发现可能为未来的预防策略提供信息。
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引用次数: 0
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Spine Journal
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