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Unravelling the association between sleep traits and reproductive cancers: A systematic review and meta-analysis 揭示睡眠特征与生殖癌症之间的关系:一项系统回顾和荟萃分析。
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.smrv.2026.102235
Eirini Pagkalidou , Christos K. Papagiannopoulos , Maria Manou , Panagiotis Filis , Rebecca C. Richmond , Konstantinos K. Tsilidis , Georgios Markozannes , Christos V. Chalitsios
Sleep traits (duration, insomnia, chronotype, snoring) are modifiable lifestyle factors that may influence cancer risk, but their association with reproductive cancers remains unclear. We systematically searched PubMed, Scopus, and Web of Science (until 09/2024) for observational studies investigating associations between sleep traits and reproductive cancers (including breast, prostate, endometrial, epithelial ovarian). We extracted estimates from maximally adjusted models and performed random-effects and dose-response meta-analyses. This study included 62 observational studies (45 cohort, 17 case-control) from 55 publications, but cohorts were primarily considered in interpretation. Compared to a morning chronotype, evening chronotype was associated with higher risk of breast cancer (HR = 1.12; 95 %CI: 1.07–1.17; I2 = 14 %; 4 cohorts) and epithelial ovarian cancer (HR = 1.15; 95 %CI: 1.02–1.29; I2 = 0 %; 2 cohorts). Insomnia was associated with elevated breast cancer risk (RR = 1.23; 95 %CI: 1.01–1.50; I2 = 94 %; 9 cohorts), and the association remained similar for diagnosed insomnia (RR = 1.26; 95 %CI: 1.01–1.58; I2 = 96 %; 5 studies), but high between-study heterogeneity was observed and the association was lost in properly adjusted studies (RR = 1.04; 95 %CI: 0.95–1.14; I2 = 41.5 %; 3 cohorts). These findings support a role for circadian disruption in carcinogenesis. Future research should use objective sleep assessments and evaluate whether modifying sleep behaviours or circadian alignment can reduce cancer risk.
睡眠特征(持续时间、失眠、睡眠类型、打鼾)是可改变的生活方式因素,可能会影响癌症风险,但它们与生殖癌症的关系尚不清楚。我们系统地检索了PubMed、Scopus和Web of Science(截至2024年9月),以调查睡眠特征与生殖癌症(包括乳腺癌、前列腺癌、子宫内膜癌、卵巢上皮癌)之间关系的观察性研究。我们从最大调整模型中提取估计,并进行随机效应和剂量-反应荟萃分析。本研究包括来自55篇出版物的62项观察性研究(45项队列研究,17项病例对照研究),但在解释时主要考虑队列研究。与早晨睡眠类型的人相比,晚上睡眠类型的人患乳腺癌(HR = 1.12; 95% CI: 1.07-1.17; I2 = 14%; 4个队列)和上皮性卵巢癌(HR = 1.15; 95% CI: 1.02-1.29; I2 = 0%; 2个队列)的风险更高。失眠与乳腺癌风险升高相关(RR = 1.23; 95% CI: 1.01-1.50; I2 = 94%; 9个队列),诊断为失眠的患者与失眠之间的关联相似(RR = 1.26; 95% CI: 1.01-1.58; I2 = 96%; 5项研究),但研究间存在较高的异质性,在适当调整的研究中,这种关联消失(RR = 1.04; 95% CI: 0.95-1.14; I2 = 41.5%; 3个队列)。这些发现支持了昼夜节律紊乱在癌变中的作用。未来的研究应该使用客观的睡眠评估,并评估改变睡眠行为或昼夜节律是否可以降低癌症风险。
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引用次数: 0
Advances in sleep research based on the Caenorhabditis elegans: an intestinal microbiota perspective and cutting-edge technology applications 基于秀丽隐杆线虫的睡眠研究进展:肠道微生物群视角和前沿技术应用
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.smrv.2026.102229
Wan-Qi Zhang , Xiao-Lin Li , Rui-Peng Xu , Yu-Long Li , Peng-Fei Hu , Ka-Hing Wong , Zhong-Yang Lin , Qiong-Qiong Yang , Bo-Bo Zhang
Sleep disorders affect approximately 27 % of the global population, driving non-pharmacological research on gut-brain axis regulation. Understanding sleep mechanisms is crucial, given its profound impact on health and disease. Caenorhabditis elegans (C. elegans) offers a powerful model for dissecting fundamental sleep processes, owing to its compact and fully mapped nervous system, genetic tractability, and suitability for high-throughput screening. This review leverages C. elegans integrated with gene editing, high-throughput behavioral phenotyping, and calcium imaging to dissect gut microbiota's role in sleep modulation. We explore how microbial metabolites regulate sleep via gut-brain pathways and summarize conserved sleep-related molecular mechanisms. The purpose of this review is to decode gut-brain-sleep axis interactions, offering novel mechanistic insights into sleep disorder pathophysiology.
睡眠障碍影响了全球约27%的人口,推动了肠-脑轴调节的非药物研究。考虑到睡眠对健康和疾病的深远影响,了解睡眠机制是至关重要的。秀丽隐杆线虫(秀丽隐杆线虫)提供了一个强大的模型,解剖基本的睡眠过程,由于其紧凑和完全映射的神经系统,遗传易感,适合高通量筛选。本综述利用秀丽隐杆线虫整合基因编辑、高通量行为表型和钙成像来解剖肠道微生物群在睡眠调节中的作用。我们探索微生物代谢物如何通过肠-脑通路调节睡眠,并总结保守的睡眠相关分子机制。本综述的目的是解码肠-脑-睡眠轴的相互作用,为睡眠障碍的病理生理学提供新的机制见解。
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引用次数: 0
Sleep apnea and substance use: a meta-analysis 睡眠呼吸暂停和物质使用:一项荟萃分析。
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2026-01-07 DOI: 10.1016/j.smrv.2025.102228
Sibylle Mauries , Benjamin Rolland , Justine Frija-Masson , Marie-Pia d’Ortho , Sébastien Catoire , Feriel Zehani , Guillaume Davido , Michel Lejoyeux , Pierre A. Geoffroy

Introduction

Sleep apnea and substance use disorders appear to interact bidirectionally, negatively influencing each other. Obstructive sleep apnea syndrome (OSA) seems particularly prevalent among substance users.

Methods

This meta-analysis aims to evaluate the impact of the most commonly used substances (alcohol, tobacco, cannabis, opioids, and cocaine) on the apnea-hypopnea index (AHI) by comparing the mean AHI scores between users and non-users.

Results

3784 articles were identified from the PubMed search, and 28 studies were included in the meta-analysis. We found a higher AHI among alcohol users (SMD: 0.46, 95 % CI [0.21–0.71] (z = 3.62; p < 0.001)) and a higher prevalence of central sleep apnea among opioid users (SMD: 0.44 95 % CI 0.24–0.64] (z = 4.37; p < 0.001)). The AHI was also elevated among tobacco users, although this difference was not statistically significant. Regarding moderators effects, sex may influence alcohol's impact, while both age and sex could affect the relationship between opioids and AHI. No studies compared the AHI of cocaine users to non-users, and only one study comparing the AHI of cannabis users to non-users were found.

Conclusion

This study highlights the importance of diagnosing and managing sleep apnea in patients with substance use, in order to improve addiction prognosis through specific treatment approaches.
睡眠呼吸暂停和物质使用障碍似乎是双向互动的,相互负向影响。阻塞性睡眠呼吸暂停综合征(OSA)似乎在药物使用者中尤为普遍。方法:本meta分析旨在通过比较使用者和非使用者之间的平均AHI评分,评估最常用物质(酒精、烟草、大麻、阿片类药物和可卡因)对呼吸暂停-低通气指数(AHI)的影响。结果:从PubMed检索中确定了3784篇文章,其中28篇研究被纳入meta分析。我们发现酒精使用者的AHI较高(SMD: 0.46, 95% CI [0.21-0.71] (z = 3.62; p)。结论:本研究强调了药物使用患者诊断和管理睡眠呼吸暂停的重要性,以便通过特定的治疗方法改善成瘾预后。
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引用次数: 0
Hypnosis as therapy for non-REM parasomnia: A literature review 催眠治疗非快速眼动睡眠异常:文献综述
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-18 DOI: 10.1016/j.smrv.2025.102227
Geoffroy Solelhac , Nina Rimorini , Chantal Berna , Francesca Siclari
This systematic review provides an overview of the use of medical hypnosis for non-rapid eye movement parasomnias. It aims to describe the hypnotic inductions and suggestions applied in this context and assess their reported effectiveness. From a total of 427 articles identified through a comprehensive search of major medical databases, 24 studies met inclusion criteria. The majority were individual case reports or small case series, with only one study using a controlled design. Across these studies, 348 individuals with non-rapid eye movement parasomnias were described, with 148 receiving treatments with hypnosis. A positive clinical response was reported in approximately 82.6 % of these treated cases. However, the overall quality of evidence was low, with most studies offering limited methodological robustness and lacking standardized outcome measures. The hypnotic induction and suggestion techniques varied widely, yet general suggestions aimed at improving sleep quality were more frequently reported than specific ones targeting parasomnia features. Nevertheless, the more specific suggestions seemed to have better outcomes. This review suggests that hypnosis could be a promising therapeutic option. However, further, well-designed trials are required, including objective outcome evaluation, and standardized, targeted hypnotic approaches developed collaboratively between sleep and hypnosis specialists.
这篇系统的综述提供了对非快速眼动异动症使用医学催眠的概述。它的目的是描述催眠诱导和建议应用在这种情况下,并评估其报告的有效性。通过对主要医学数据库的全面检索,从总共427篇文章中确定,24项研究符合纳入标准。大多数是个案报告或小病例系列,只有一项研究采用对照设计。在这些研究中,348名非快速眼动异动症患者被描述,其中148人接受了催眠治疗。据报道,这些治疗病例中约有82.6%的临床反应为阳性。然而,证据的总体质量较低,大多数研究提供有限的方法稳健性,缺乏标准化的结果测量。催眠诱导和暗示技术差异很大,但旨在改善睡眠质量的一般建议比针对睡眠异常特征的特定建议更频繁地被报道。然而,更具体的建议似乎有更好的结果。这篇综述表明,催眠可能是一种很有前途的治疗选择。然而,进一步需要精心设计的试验,包括客观的结果评估,以及由睡眠和催眠专家合作开发的标准化、有针对性的催眠方法。
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引用次数: 0
Handling Editor: Monica AndersenA global perspective of parent engagement with digital sleep health interventions for young children: A scoping review 家长参与幼儿数字睡眠健康干预的全球视角:范围审查
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-13 DOI: 10.1016/j.smrv.2025.102226
Alicia Chung , Laurel Deaton , Jennifer Miller , Ashley Nechyba , Jenny Liu , Menessa Metayer , Tayla von Ash , Michelle Thompson , Shayla K. Shorter , Dorice Vieira , Azizi A. Seixas , Girardin Jean-Louis

Introduction

We examined the landscape of early childhood sleep health interventions that utilized digital tools designed for parents to improve sleep health outcomes during early childhood, (ages 3–8).

Methods

We performed a scoping review of peer-reviewed articles published from inception to April 2025 from the following databases: PubMed, Embase, Web of Science, MEDLINE, Cochrane Library, Engineering Village, Global Health, citation searching, and others. Two medical science librarians conducted the extensive literature search, with strategies detailed at [osf.io/74hba]. This study was guided by the implementation science outcomes framework.

Results

Twenty-one articles met the final inclusion criteria. Included studies reported clinical sleep, behavioral and/or implementation science outcomes. Implementation science outcomes primarily focused on acceptability, appropriateness and feasibility of pediatric digital sleep and family-based tools. Mobile apps were most prominently used, followed by websites and telehealth. Websites contributed to improved child sleep duration, sleep onset, sleep efficiency, daytime sleepiness and reduced night wakings. Mobile apps reported the aforementioned child sleep outcomes, as well as improvements in parent mental health and daytime functioning.

Conclusions

Digital sleep health tools have the potential to ameliorate sleep problems in young children. Digital interventions may improve sleep and wellbeing in the family unit.
前言:我们研究了儿童早期睡眠健康干预措施的现状,这些干预措施利用为父母设计的数字工具来改善儿童早期(3-8岁)的睡眠健康结果。方法我们对从成立到2025年4月发表的同行评议文章进行了范围审查,这些文章来自以下数据库:PubMed、Embase、Web of Science、MEDLINE、Cochrane Library、Engineering Village、Global Health、引文搜索等。两位医学图书管理员进行了广泛的文献检索,详细策略见[osf.io/74hba]。本研究以实施科学成果框架为指导。结果21篇文章符合最终纳入标准。纳入的研究报告了临床睡眠、行为和/或实施科学的结果。实施科学成果主要集中在儿童数字睡眠和基于家庭的工具的可接受性、适当性和可行性上。使用最多的是移动应用程序,其次是网站和远程医疗。网站有助于改善儿童的睡眠时间、睡眠开始、睡眠效率、白天嗜睡和减少夜间醒来。移动应用程序报告了上述儿童的睡眠结果,以及父母心理健康和白天功能的改善。结论数字睡眠健康工具具有改善幼儿睡眠问题的潜力。数字干预可能会改善家庭的睡眠和健康。
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引用次数: 0
Time to take the Declaration of Helsinki seriously? A systematic review of comparison conditions in clinical trials on internet-delivered cognitive behavioral therapy for insomnia 是时候认真对待《赫尔辛基宣言》了?网络认知行为治疗失眠症临床试验比较条件的系统回顾
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.smrv.2025.102224
Lorenz Grolig , Hanna Brückner , Hannah Heimes , Claudia Buntrock , Christin Hempeler , Kai Spiegelhalder , Dirk Lehr
The Declaration of Helsinki (DoH) provides guidance on the choice of comparators in clinical trials, stating that new treatments must be compared against the best proven treatment. This systematic review examines whether research on a new treatment – internet-delivered cognitive behavioral therapy for insomnia (iCBT-I) – has adhered to these DoH requirements. A systematic literature search for randomized controlled trials (RCTs) testing iCBT-I in clinical samples was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To identify the gold standard treatment, national guidelines were analyzed for all countries where published research on iCBT-I had been conducted.
After screening, 32 RCTs and seven guidelines for 12 countries were included. Almost all guidelines recommend face-to-face CBT-I as the gold standard, but only four (12.5 %) of the RCTs used this gold standard as a comparator. None of the other trials explained why they did not follow the DoH's recommendation.
The majority of clinical trials did not compare iCBT-I against the gold standard. As the DoH is intended to guide clinical research ethics, this low level of adherence is remarkable, and it raises uncertainty for patients, therapists, and policymakers about the effectiveness of iCBT-I compared to the gold standard treatment.
《赫尔辛基宣言》(DoH)为临床试验中比较物的选择提供了指导,指出必须将新治疗方法与已证实的最佳治疗方法进行比较。这篇系统综述研究了一种新的治疗方法——互联网传递的失眠认知行为疗法(iCBT-I)——是否符合这些DoH要求。按照系统评价和荟萃分析的首选报告项目(PRISMA)指南,对临床样本中检测iCBT-I的随机对照试验(rct)进行了系统文献检索。为了确定金标准治疗,对已发表icbt - 1研究的所有国家的国家指南进行了分析。筛选后,纳入了12个国家的32项随机对照试验和7项指南。几乎所有的指南都推荐面对面的CBT-I作为金标准,但只有四个(12.5%)的随机对照试验使用这一金标准作为比较。其他试验都没有解释为什么他们没有遵循卫生部的建议。大多数临床试验没有将iCBT-I与黄金标准进行比较。由于DoH旨在指导临床研究伦理,这种低水平的依从性是值得注意的,它给患者、治疗师和政策制定者带来了与金标准治疗相比iCBT-I有效性的不确定性。
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引用次数: 0
Does short- and long-term exposure to air pollution affect the risk of obstructive sleep apnea? A systematic review and meta-analysis 短期和长期暴露在空气污染中会影响阻塞性睡眠呼吸暂停的风险吗?系统回顾和荟萃分析
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.smrv.2025.102225
Yansu He , Shuting Wang , Tianhang Zhang , Yuxuan Gu , Zuyao Yang , Linying Wu , Kin Fai Ho
The contribution of air pollution to obstructive sleep apnea (OSA) remains unclear. This systematic review and meta-analysis evaluated the impact of air pollution across different exposure windows on OSA and examined effect modifiers. Pubmed, Web of Science, and Embase were searched from inception to September 2024. Meta-analyses synthesized risk estimates using fixed- or random-effects models with I2 heterogeneity assessment. Certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. Of 5196 potential papers, 20 studies were included, with 13 eligible for meta-analysis. High-certainty evidence indicated that each 10 μg/m3 increase in short- and long-term PM2.5 exposure was associated with a 2.25 % (95 % CI: 1.10 to 3.41) and 13.33 % (95 % CI: 9.85 to 16.80) increase in apnea-hypopnea index (AHI), respectively. For NO2, each 10 ppb increase in short- and long-term exposure was associated with a 2.92 % (95 % CI: 1.29 to 4.54) and 8.93 % (95 % CI: 2.06 to 15.79) increase in AHI, with high- and moderate-certainty evidence, respectively. Medium-term PM2.5 and NO2 exposure were also associated with AHI, although with low certainty. No significant associations were observed for PM10 and O3. Exposure to PM2.5 and NO2, but not PM10 or O3, was associated with OSA severity.
空气污染对阻塞性睡眠呼吸暂停(OSA)的影响尚不清楚。本系统综述和荟萃分析评估了不同暴露窗口的空气污染对OSA的影响,并检查了影响调节剂。Pubmed, Web of Science和Embase从成立到2024年9月进行了搜索。荟萃分析使用固定或随机效应模型综合风险估计,并进行I2异质性评估。证据的确定性采用GRADE(建议评估、发展和评价分级)方法进行评估。在5196篇潜在论文中,纳入了20篇研究,其中13篇符合meta分析的条件。高确定性证据表明,短期和长期PM2.5暴露每增加10 μg/m3,呼吸暂停低通气指数(AHI)分别增加2.25% (95% CI: 1.10至3.41)和13.33% (95% CI: 9.85至16.80)。对于二氧化氮,短期和长期暴露每增加10 ppb, AHI分别增加2.92% (95% CI: 1.29至4.54)和8.93% (95% CI: 2.06至15.79),具有高确定性和中等确定性的证据。中期PM2.5和NO2暴露也与AHI相关,尽管确定性较低。PM10和O3没有明显的相关性。暴露于PM2.5和NO2,而不是PM10或O3,与OSA严重程度相关。
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引用次数: 0
OSA, CPAP, and the impact on cardiometabolic parameters: what is next? OSA、CPAP和对心脏代谢参数的影响:下一步是什么?
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.smrv.2025.102213
Luciano F. Drager
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引用次数: 0
Forecasting the burden of insomnia: A call to action 预测失眠的负担:行动的呼吁
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.smrv.2025.102211
Wenxin Bao, Rong Ren, Xiangdong Tang, Ye Zhang
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引用次数: 0
Artificial intelligence and sleep medicine II: A scoping review of applications, advancements, and future directions 人工智能和睡眠医学II:应用、进展和未来方向的范围审查。
IF 9.7 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-11-28 DOI: 10.1016/j.smrv.2025.102212
Haitham Jahrami , Waqar Husain , Khaled Trabelsi , Thomas Penzel , Max Hirshkowitz , Javad Razjouyan , Ahmed S. BaHammam , Amir Sharafkhaneh

Background

Artificial intelligence (AI) has rapidly advanced in sleep medicine, offering innovative solutions for sleep disorder management. The integration of AI technologies presents unprecedented opportunities to address longstanding challenges in diagnosis, monitoring, and treatment.

Methods

This scoping review summarizes current AI applications in sleep medicine following PRISMA-ScR. A comprehensive search was conducted across various databases from inception to 2024, following PRISMA-ScR guidelines. Eligible studies included original AI research, systematic reviews, and meta-analyses focusing on sleep medicine.

Results

AI models for obstructive sleep apnea (OSA) detection demonstrated accuracy between 85 % and 99 % in controlled settings, with outlier up to 99.9 %. Deep learning approaches for sleep staging and quality assessment match human expert performance. AI applications have extended to other disorders like insomnia and narcolepsy. Wearable technologies and non-contact sensors enable continuous monitoring outside laboratory settings, with some achieving sensitivity >96 % and specificity >97 % for OSA detection. Significant real-world validation gaps persist.

Conclusions

While AI shows transformative potential in sleep medicine, implementation challenges remain. Future research should prioritize multicenter validation, ethical governance, and culturally inclusive AI frameworks to ensure safe and equitable clinical translation. Addressing ethical considerations and standardizing methodological reporting are essential for widespread adoption of these technologies in clinical practice.
背景:人工智能(AI)在睡眠医学领域迅速发展,为睡眠障碍管理提供了创新的解决方案。人工智能技术的整合为解决诊断、监测和治疗方面的长期挑战提供了前所未有的机遇。方法:本文综述了prism - scr后人工智能在睡眠医学中的应用现状。根据PRISMA-ScR指南,从成立到2024年,在各种数据库中进行了全面的搜索。符合条件的研究包括原始的人工智能研究、系统综述和关注睡眠医学的荟萃分析。结果:用于阻塞性睡眠呼吸暂停(OSA)检测的人工智能模型在受控环境下的准确率在85%至99%之间,异常值高达99.9%。深度学习的睡眠分期和质量评估方法与人类专家的表现相匹配。人工智能的应用已经扩展到失眠和嗜睡症等其他疾病。可穿戴技术和非接触式传感器可以在实验室环境之外进行连续监测,其中一些检测OSA的灵敏度为bbbb96 %,特异性为bbbb97 %。显著的现实验证差距仍然存在。结论:虽然人工智能在睡眠医学中显示出变革潜力,但实施方面的挑战仍然存在。未来的研究应优先考虑多中心验证、伦理治理和文化包容性的人工智能框架,以确保安全和公平的临床翻译。解决伦理问题和标准化方法报告是在临床实践中广泛采用这些技术的必要条件。
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引用次数: 0
期刊
Sleep Medicine Reviews
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