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Particle filter–based data assimilation in dynamic data-driven simulation: sensitivity analysis of three critical experimental conditions 动态数据驱动仿真中基于粒子滤波的数据同化:三个关键实验条件的敏感性分析
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-26 DOI: 10.1177/00375497221143988
Yilin Huang, Xu Xie, Yubin Cho, A. Verbraeck
Data assimilation (DA) is a methodology widely used by different disciplines of science and engineering. It is typically applied to continuous systems with numerical models. The application of DA to discrete-event and discrete-time systems including agent-based models is relatively new. Because of its non-linearity and non-Gaussianity, the particle filter (PF) method is often a good option for stochastic simulation models of discrete systems. The probability distributions of model runs, however, make it computationally intensive. The experimental conditions therein are understudied. This paper studied three critical conditions of PF-based DA in a discrete event model: (1) the time interval between two consecutive DA iterations, (2) the number of particles, and (3) the actual level and perceived level of measurement errors (or noises). The study conducted identical-twin experiments of an M/M/1 single server queuing system. The ground truth is imitated in a stand-alone simulation model. The measurement errors are superimposed so that the effect of the three conditions can be quantitatively evaluated in a controlled manner. The results show that the estimation accuracy of such a system using PF is more constrained by the choice of time intervals than the number of particles. An under estimation of measurement errors produces worse state estimates than an over estimation of errors. A correct perception of the measurement errors does not guarantee better state estimates. Moreover, a slight over estimation of errors results in better state estimates, and it is more responsive to abrupt system changes than an accurate perception of measurement errors.
数据同化(Data assimilation, DA)是一种广泛应用于不同科学和工程学科的方法。它通常应用于具有数值模型的连续系统。数据分析在离散事件和离散时间系统(包括基于智能体的模型)中的应用相对较新。粒子滤波(PF)方法由于其非线性和非高斯性,通常是离散系统随机仿真模型的一个很好的选择。然而,模型运行的概率分布使其计算量很大。其中的实验条件还有待进一步研究。本文研究了离散事件模型下基于pf的数据处理的三个关键条件:(1)连续两次数据处理迭代之间的时间间隔,(2)粒子数量,(3)测量误差(或噪声)的实际水平和感知水平。本研究对M/M/1单服务器排队系统进行了同卵双胞胎实验。在一个独立的仿真模型中模拟真实情况。测量误差叠加在一起,从而可以以可控的方式定量地评价这三种条件的影响。结果表明,时间间隔的选择比粒子个数的选择更能约束系统的估计精度。对测量误差的估计不足比对误差的估计过高产生更差的状态估计。对测量误差的正确感知并不能保证更好的状态估计。此外,对误差的轻微过度估计会导致更好的状态估计,并且它比对测量误差的准确感知更能响应系统的突然变化。
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引用次数: 0
Simulation modelling of hospital outpatient department: a review of the literature and bibliometric analysis 医院门诊部模拟建模:文献回顾与文献计量学分析
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-22 DOI: 10.1177/00375497221139282
Aby M Philip, S. Prasannavenkatesan, N. Mustafee
The increase in demand for outpatient departments (OPDs) has contributed to overcrowded clinics and patient dissatisfaction. Computer simulation can help decision-makers meet the operational challenge of balancing the demand for outpatient services with considerations of available capacity. The paper presents a synthesis of the literature on simulation modeling in OPD using two approaches: a bibliometric analysis (employing keyword co-occurrence network) and a literature classification focusing on OPD strategy, OPD performance measures, and simulation techniques. Our review is based on 161 papers, published between 2006 and 2020, identified through a methodological search of the literature. The objective of the review is threefold: (1) to identify the major and emerging research issues in general and specialized OPD, (2) to find the commonly used performance measures in OPD and how it is associated with the strategies used to improve the performance, and (3) to identify the commonly used simulation methods for OPD modeling. A key finding from the bibliometric analysis is that most OPD research can be classified under one of the four clusters—“organization and management,”“patient satisfaction,”“overbooking,” and “performance.” We also find that patient waiting time has received much attention among the performance measures reported in the literature, followed by server idle time/overtime (server here is the OPD consultant or other healthcare resource). Our review serves as a key reference point for scholars, practitioners, students, and healthcare stakeholders, and those who use quantitative tools to aid operational decision-making.
对门诊部需求的增加导致了诊所人满为患和患者不满。计算机模拟可以帮助决策者应对平衡门诊服务需求和考虑可用容量的操作挑战。本文使用两种方法综合了OPD仿真建模方面的文献:文献计量分析(采用关键词共现网络)和关注OPD策略、OPD性能度量和仿真技术的文献分类。我们的综述基于2006年至2020年间发表的161篇论文,通过文献的方法学搜索确定。回顾的目的有三个:(1)确定一般和专业OPD中的主要和新兴研究问题,(2)找到OPD中常用的性能度量以及它如何与用于提高性能的策略相关联,以及(3)确定OPD建模的常用仿真方法。文献计量分析的一个关键发现是,大多数OPD研究可以归为四类之一——“组织和管理”、“患者满意度”、“超额预约”和“绩效”。我们还发现,在文献中报告的绩效指标中,患者等待时间受到了很多关注,其次是服务器空闲时间/超时时间(这里的服务器是OPD顾问或其他医疗保健资源)。我们的综述为学者、从业人员、学生和医疗保健利益相关者以及那些使用定量工具帮助运营决策的人提供了关键参考点。
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引用次数: 2
Simulation-driven experimental hypotheses and design: a study of price impact and bubbles 模拟驱动的实验假设与设计:价格影响与泡沫研究
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-13 DOI: 10.1177/00375497221138923
F. Cordoni, Caterina Giannetti, F. Lillo, G. Bottazzi
A crucial aspect of every experiment is the formulation of hypotheses prior to data collection. In this paper, we use a simulation-based approach to generate synthetic data and formulate the hypotheses for our market experiment and calibrate its laboratory design. In this experiment, we extend well-established laboratory market models to the two-asset case, accounting at the same time for heterogeneous artificial traders with multi-asset strategies. Our main objective is to identify the role played in the price-bubble formation by both self-impact (i.e., how trading orders affect the price dynamics) and cross-impact (i.e., the price changes in one asset caused by the trading activity on other assets). To this end, we vary across treatments the possibility of traders of diverting their capital from one asset to the other, thereby artificially changing the amount of liquidity in the market. To simulate different scenarios for the synthetic data generation, we vary along with the liquidity the type of trading strategies of our artificial traders. Our results suggest that an increase in liquidity increases the cross-impact, especially when agents are market-neutral. Self-impact, however, remains significant and constant for all model specifications.
每个实验的一个关键方面是在数据收集之前提出假设。在本文中,我们使用基于模拟的方法来生成合成数据,并为我们的市场实验制定假设,并校准其实验室设计。在本实验中,我们将完善的实验室市场模型扩展到双资产情况,同时考虑具有多资产策略的异质人工交易者。我们的主要目标是通过自我影响(即交易指令如何影响价格动态)和交叉影响(即由其他资产的交易活动引起的一种资产的价格变化)确定在价格泡沫形成中所起的作用。为此,我们对交易者将其资本从一种资产转移到另一种资产的可能性进行了不同的处理,从而人为地改变了市场的流动性。为了模拟合成数据生成的不同场景,我们根据流动性改变了人工交易者的交易策略类型。我们的研究结果表明,流动性的增加增加了交叉影响,特别是当代理人是市场中立的。然而,对于所有模型规范,自影响仍然是重要的和恒定的。
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引用次数: 2
Simulation of luggage-laden passengers’ behavior in the evacuation process based on a floor field CA model case study: Tehran metro-rail transfer corridor 基于层场CA模型的行李乘客疏散行为模拟——以德黑兰地铁换乘走廊为例
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-10 DOI: 10.1177/00375497221140918
Fatemeh Jahedinia, M. Bagheri, A. Naderan, Zahra Bahramian
Passengers’ safety against unexpected incidents such as rail stations’ fire accidents is essential in the safety field. The presence of luggage with passengers occupies extra space, diminishes passenger’s velocity in high densities, and consequently increases the evacuation time. Therefore, studying the mixture of luggage-laden passengers with non-luggage-laden passengers during the emergency evacuation time of a rail station is vital. In this paper, a simulation of a metro-rail transfer station using an extended cellular automata (CA) model is used to illustrate the importance of this consideration. In this model, luggage-laden passengers and non-luggage-laden passengers are defined as two-cell and one-cell groups, respectively. Specific parameters for luggage-laden passengers in minimum wall prevention and velocity are used. Also, the volume of each passenger group is extracted from the Wi-Fi scanners during the busiest time of the normal station operational hours due to metro and railway schedules. The simulation is carried out using the Python programming language. Fourteen scenarios that vary in their impact on the three classifications of station infrastructure, station equipment, and management’s approach are presented. The analysis indicates that approximately 28% of passengers, or 236 passengers, will not be evacuated in the time period predicted by the simulation if the luggage is not considered. Interestingly, resizing retail stores in the corridor reduced emergency evacuation times by 6.3%, the equivalent of removing them. Failures in the two escalators affect an 8% and 9.4% increase in emergency evacuation time and cause 28 and 46 more passengers to be trapped, respectively. Although the construction of the second railway entrance corridor has been suspended, results indicate that it will save 67 passengers and reduce evacuation time by 9.5%.
铁路车站火灾等突发事件对乘客安全的影响是安全领域的核心问题。旅客行李的存在占用了额外的空间,降低了高密度旅客的速度,从而增加了疏散时间。因此,研究铁路车站紧急疏散期间行李乘客与非行李乘客的混合情况具有重要意义。本文利用扩展元胞自动机(CA)模型对地铁轨道换乘站进行了仿真,说明了这一考虑的重要性。在该模型中,将携带行李的乘客和不携带行李的乘客分别定义为两个单元组和一个单元组。在最小壁防和速度方面使用了载运行李乘客的特定参数。此外,由于地铁和铁路时刻表的原因,在车站正常运营的最繁忙时间,每个乘客群体的数量都是从Wi-Fi扫描仪中提取出来的。采用Python编程语言进行仿真。提出了14种不同的情景,它们对车站基础设施、车站设备和管理方法的三种分类有不同的影响。分析表明,如果不考虑行李,在模拟预测的时间内,大约28%的乘客,即236名乘客将不会被疏散。有趣的是,调整走廊内零售商店的规模可以减少6.3%的紧急疏散时间,相当于拆除它们。两部自动扶梯故障导致紧急疏散时间分别增加8%和9.4%,并分别造成28名和46名乘客被困。虽然铁路第二出入口走廊的建设已经暂停,但结果表明,它将节省67名乘客,并减少9.5%的疏散时间。
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引用次数: 3
A discrete simulation-based optimization approach for multi-period redeployment in emergency medical services 基于离散仿真的应急医疗服务多期再部署优化方法
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-09 DOI: 10.1177/00375497221139870
Lina Aboueljinane, E. Sahin, Z. Jemai
Emergency Medical Service (EMS) managers continuously strive to improve the coverage performance, i.e., the percentage of calls responded to within a specific target time, to save lives in case of life-threatening emergencies. This goal can be achieved by dynamically adjusting the location of rescue teams during a day in response to some temporal or geographical fluctuations such as demand patterns, traffic conditions, or the number of teams on duty. This relocation is known as the multi-period redeployment problem. In this study, we propose a discrete simulation-based optimization model to adress the multi-period redeployment problem in the French EMS of the Val-de-Marne department (France), named SAMU 94. The proposed model uses an iterative method that combines the use of a mathematical model to find the optimal locations of rescue teams with the use of the SAMU 94 simulation model implemented in Arena software, to evaluate the busy fraction parameters required to solve the mathematical model. The model performance was compared with that of the simulation-based optimization software, OptQuest. The experimental results demonstrated that the iterative method could produce solutions with better coverage performance, 20 times faster than OptQuest.
紧急医疗服务(EMS)管理人员不断努力提高覆盖绩效,即在特定目标时间内响应呼叫的百分比,以便在危及生命的紧急情况下挽救生命。这一目标可以通过根据需求模式、交通状况或当值队伍数量等时间或地理波动动态调整一天中救援队的位置来实现。这种重新部署被称为多期重新部署问题。在这项研究中,我们提出了一个基于离散仿真的优化模型来解决Val-de-Marne部门(法国)的法国EMS的多周期重新部署问题,命名为SAMU 94。该模型采用迭代法,将利用数学模型寻找救援队伍的最佳位置与利用Arena软件实现的SAMU 94仿真模型相结合,评估求解数学模型所需的忙分数参数。将该模型的性能与基于仿真的优化软件OptQuest进行了比较。实验结果表明,迭代方法可以获得更好的覆盖性能,比OptQuest快20倍。
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引用次数: 2
Interactive route choice and prescriptive information on degradable network 可降解网络的交互路径选择与规定性信息
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-01 DOI: 10.1177/00375497221105527
Manman Li, Jian Lu, Jiahui Sun
This study models and analyzes the dynamic interaction between route choice and prescriptive information on a degradable network. The predictively prescriptive information is first explicitly modeled based on travelers’ behavior and historical data. Its accuracy is then dynamically measured to adjust the information compliance rate based on travelers’ expectations and experiences. Finally, a logit function is adopted to describe travelers’ route choice. Based on the proposed model, the dynamic interaction between route choice and prescriptive information on a degradable network is investigated by theoretical analyses and numerical experiments, which provides insights for the design and operation of advanced traveler information systems and traffic management.
本文对可降解网络中路径选择与规定性信息之间的动态交互作用进行了建模和分析。首先,基于旅行者的行为和历史数据明确地建立了预测性规范信息的模型。然后根据旅行者的期望和经验动态测量其准确性,以调整信息遵从率。最后,采用logit函数描述出行者的路线选择。基于该模型,通过理论分析和数值实验研究了可降解交通网络中路径选择与规定性信息之间的动态交互作用,为先进出行信息系统的设计和运行以及交通管理提供了理论依据。
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引用次数: 0
Electromagnetic wave forward modeling of coal-gangue mixed model in top coal caving mining face 放顶煤矸石混合模型的电磁波正演模拟
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-01 DOI: 10.1177/00375497221105290
Lei Si, Feng Xing, Zhongbin Wang, Chao Tan
The automatic control of top coal caving is of great significance to realize intelligent coal mining. In the process of top coal caving, a coal-gangue mixed area containing coal, gangue, and air is formed at the tail beam of the hydraulic support, which has different electromagnetic parameters, different volumes, and different shapes. To explore the transmission characteristics of electromagnetic wave in coal-gangue mixed model and the influence of different gangue ratios on electromagnetic wave propagation, the coal-gangue mixed model is established based on the random medium theory. Some electromagnetic forward modeling is carried out with different coal-gangue granularities, electromagnetic parameters, and gangue ratios based on finite-difference time-domain (FDTD) and finite-integration time-domain (FITD) methods. The results show that different granularities of coal and gangue will affect the amplitude of electromagnetic wave time-domain waveform. Under the same particle size, the equivalent electromagnetic parameters in the coal-gangue mixed medium will be larger with higher gangue ratio. Furthermore, the difference of transmitted wave signals between different gangue ratios will be larger with higher electromagnetic parameters difference of the coal and gangue. For higher refractive index, the propagation velocity of electromagnetic wave in the medium and the transmitted wave amplitude will be smaller. In addition, the comparison results illustrate that the rules of electromagnetic wave propagation obtained by FDTD and FITD methods are basically the same, which verifies the correctness of the simulations in this paper. The simulation results can lay a theoretical foundation for identifying the coal-gangue mixed degree in the process of top coal caving.
放顶煤自动控制对实现智能采煤具有重要意义。放顶煤过程中,在液压支架尾梁处形成含煤、矸石、空气的煤矸石混合区,该混合区具有不同的电磁参数、不同的体积、不同的形状。为了探索电磁波在煤矸石混合模型中的传播特性以及不同煤矸石配比对电磁波传播的影响,基于随机介质理论建立了煤矸石混合模型。基于时域有限差分(FDTD)和时域有限积分(FITD)方法,对不同煤矸石粒度、电磁参数和煤矸石比进行了电磁正演模拟。结果表明,煤和矸石的不同粒度会对电磁波时域波形的振幅产生影响。在相同粒度下,煤矸石掺比越大,煤矸石混合介质中等效电磁参数越大。煤与矸石电磁参数差异越大,不同煤矸石比之间透射波信号差异越大。折射率越高,电磁波在介质中的传播速度越快,透射波幅越小。此外,对比结果表明,FDTD法和FITD法得到的电磁波传播规律基本一致,验证了本文仿真的正确性。模拟结果可为顶煤放煤过程中煤矸石混合程度的识别奠定理论基础。
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引用次数: 2
Simulation study on the influence of wheel irregularity on the vertical dynamics of wheel–rail interaction for high-speed railway track using bond graph 基于键合图的高速铁路车轮不平顺度对轮轨相互作用垂直动力学影响的仿真研究
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-12-01 DOI: 10.1177/00375497221138943
Yamika Patel, V. Rastogi, W. Borutzky
Dynamic interaction between train wheel and high-speed slab is an important issue when evaluating the contact force at the wheel–rail interface under the influence of an irregularity either on the train wheel or on the rail. In this paper, an influence of amplitude of irregularity along with the vehicle speed on the dynamics of wheel–rail interaction for high-speed railway tracks is being analyzed. For this purpose, single-wheel high-speed railway (HSR) track interaction models are developed using the bond graph modeling technique. The HSR track model consists of two layers of beam, i.e., rail and concrete slab. Both the rail and slab track is modeled using the Euler–Bernoulli beam theory. The Hertzian contact theory at the wheel–rail interface has been considered for this analysis. The vertical dynamic interaction between a train wheel and a high-speed slab track is compiled in the time domain using a bond graph approach coupled with a technique known as modal superposition. Irregularity present on the wheel is characterized as smooth, moderate, and severe depending upon the variation of irregularity amplitude. An expeditious increase of maximum contact force has been observed between the speed range of 200 and 250 km/h. Beyond the speed of 250 km/h, there is a gradual increment of contact force up to its peak value. When the train speed is beyond 288 km/h, there is a gradual decrease in maximum contact force. This kind of several other useful dynamic responses in terms of wheel acceleration and wheel–rail overlap are also evaluated.
在列车车轮或钢轨不平整度影响下,评估轮轨界面接触力时,列车车轮与高速板的动力相互作用是一个重要问题。本文分析了高速铁路轨道不平顺度振幅随车速变化对轮轨相互作用动力学的影响。为此,利用键合图建模技术建立了单轮高速铁路轨道相互作用模型。高铁轨道模型由两层梁组成,即钢轨和混凝土板。钢轨和板轨均采用欧拉-伯努利梁理论建模。在此分析中考虑了轮轨界面处的赫兹接触理论。利用键合图方法和模态叠加技术,在时域内编制了列车车轮与高速板状轨道之间的垂直动力相互作用。存在于车轮上的不规则性根据不规则幅度的变化分为平滑、中度和严重。在200至250公里/小时的速度范围内,最大接触力迅速增加。在250 km/h以上,接触力逐渐增大,直至达到峰值。当列车速度超过288 km/h时,最大接触力逐渐减小。在车轮加速度和轮轨重叠方面,还对这类其他几种有用的动态响应进行了评估。
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引用次数: 1
Multi-Objective Patient Appointment Scheduling Framework (MO-PASS): a data-table input simulation–optimization approach 多目标患者预约调度框架(MO-PASS):一种数据表输入模拟优化方法
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-11-28 DOI: 10.1177/00375497221132574
Mohammad Dehghanimohammadabadi, Mandana Rezaeiahari, Javad Seif
Appointment scheduling is one of the critical factors for improving patient satisfaction with healthcare services. A practical and robust appointment scheduling solution allows clinics to efficiently utilize medical devices, equipment, and other resources. This study introduces a Multi-Objective Patient Appointment Scheduling (MO-PASS) framework to enhance clinic operations and quality of care. The proposed framework integrates three modules: (1) Optimization (using MATLAB), (2) Data-Exchange (MS Excel), and (3) Simulation (Simio). To implement MO-PASS, the Multi-Objective Particle Swarm Optimization (MOPSO) algorithm is coded in MATLAB, and a Simio API is developed, which exchanges simulated scenarios with MOPSO via Excel. The efficiency of the proposed framework is evaluated in a breast cancer clinic with multiple physicians and patient types. Two objective functions are defined for evaluating the solutions of the AS problem: (1) minimizing the total service time and (2) maximizing the number of (admitted) patients with zero overtime. Finally, the performance of MO-PASS is tested against three heuristic approaches with respect to objective functions. The computational experiment results show that the proposed MO-PASS outperforms the existing heuristic benchmarks. Also, the framework is accompanied by all the necessary details to make it practical and easy to implement.
预约安排是提高患者对医疗保健服务满意度的关键因素之一。一个实用且健壮的预约调度解决方案允许诊所有效地利用医疗设备、设备和其他资源。本研究引入多目标病患预约安排(MO-PASS)架构,以提升诊所运作及护理品质。提出的框架集成了三个模块:(1)优化(使用MATLAB),(2)数据交换(MS Excel)和(3)仿真(Simio)。为了实现MO-PASS,在MATLAB中编写了多目标粒子群优化(MOPSO)算法,并开发了Simio API,通过Excel与MOPSO交换仿真场景。在一个有多个医生和患者类型的乳腺癌诊所中,对所提出的框架的效率进行了评估。定义了两个目标函数来评估AS问题的解决方案:(1)最小化总服务时间和(2)最大化(入院)患者的数量。最后,针对目标函数的三种启发式方法对MO-PASS的性能进行了测试。计算实验结果表明,所提出的MO-PASS优于现有的启发式基准。此外,该框架还附带了所有必要的细节,使其实用且易于实现。
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引用次数: 0
Combination of anti-PD-L1 and radiotherapy in hepatocellular carcinoma: a mathematical model with uncertain parameters 抗pd - l1联合放疗治疗肝癌:一个参数不确定的数学模型
IF 1.6 4区 工程技术 Q2 Computer Science Pub Date : 2022-11-19 DOI: 10.1177/00375497221133846
Sajad Shafiekhani, N. Gheibi, Azam Janati Esfahani
Blockade of programmed death-ligand-1 (PD-L1) as a new method of immunotherapy for cancers has shown limited efficacy in hepatocellular carcinoma (HCC). The combination of anti-PD-L1 and radiotherapy (RT) enhances the antitumor effect in HCC cancer. The efficacy and interactions of these treatments can be addressed by a mathematical model. We developed a mathematical model using a set of ordinary differential equations (ODEs). The variables include cancer cells, cytotoxic T lymphocytes (CTLs), programmed cell death-1 (PD-1), PD-L1, anti-PD-L1, and ionizing radiation. The model is parameterized with imprecise data set of murine HCC model and the effect of parametric uncertainty is assessed by the fuzzy theorem. The global sensitivity analysis (GSA) is performed to assess model robustness against perturbation in parameters and to identify the most influential parameters on the dynamics of cells and proteins. In silico predictions are consistent with experimental data. The model simulation shows that anti-PD-L1 and RT have a synergistic effect. In silico assessment of treatments’ efficacy in the fuzzy setting of parameters revealed that anti-PD-L1 therapy, RT, and combination treatment caused the uncertainty band of tumor cells to lead to lower populations. This model as a validated rigorous simulation framework can be used to deepen our understanding of tumor and immune cell interactions and helps clinicians to investigate the efficacy of different time schedules of anti-PD-L1, RT, and combination therapy. The fuzzy theorem in conjunction with the classical ODE model that is parameterized by imprecise data was used to predict reliable outcomes of treatment.
阻断程序性死亡配体-1 (PD-L1)作为一种新的癌症免疫治疗方法,在肝细胞癌(HCC)中显示出有限的疗效。抗pd - l1联合放疗(RT)可增强肝癌的抗肿瘤作用。这些治疗的疗效和相互作用可以通过一个数学模型来解决。我们利用一组常微分方程(ode)建立了一个数学模型。变量包括癌细胞、细胞毒性T淋巴细胞(ctl)、程序性细胞死亡-1 (PD-1)、PD-L1、抗PD-L1和电离辐射。采用不精确的小鼠肝细胞癌模型数据集对模型进行参数化,并利用模糊定理对参数不确定性的影响进行评价。进行全局敏感性分析(GSA)以评估模型对参数扰动的鲁棒性,并确定对细胞和蛋白质动力学影响最大的参数。计算机预测与实验数据是一致的。模型仿真表明,抗pd - l1和RT具有协同效应。在参数模糊设置下对治疗效果的计算机评价显示,抗pd - l1治疗、RT和联合治疗导致肿瘤细胞的不确定性带降低。该模型作为一个经过验证的严格的模拟框架,可以用来加深我们对肿瘤和免疫细胞相互作用的理解,并帮助临床医生研究抗pd - l1、RT和联合治疗的不同时间计划的疗效。将模糊定理与经典的ODE模型相结合,用不精确的数据参数化来预测可靠的治疗结果。
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引用次数: 0
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