Pub Date : 2023-08-28DOI: 10.1177/00375497231189749
Emin Deniz Özkan, S. Nas
In the face of developments in maritime transportation due to globalization, ports are tending toward new tugboat investments in order to respond to the increasing demand. Due to the high costs of tugboats, organizations may face high investment costs. It is important to determine the most suitable number of tugboats, considering the variables in a port area where towage services will be provided. In this study, a simulation model was developed to determine sufficient tugboat allocation according to some variables in ports. The simulation model was subjected to various experiments, and statistical analyses of the obtained results were performed. The relationships between the variables affecting the level of towage service were revealed.
{"title":"A simulation model for resource allocation in port towage services","authors":"Emin Deniz Özkan, S. Nas","doi":"10.1177/00375497231189749","DOIUrl":"https://doi.org/10.1177/00375497231189749","url":null,"abstract":"In the face of developments in maritime transportation due to globalization, ports are tending toward new tugboat investments in order to respond to the increasing demand. Due to the high costs of tugboats, organizations may face high investment costs. It is important to determine the most suitable number of tugboats, considering the variables in a port area where towage services will be provided. In this study, a simulation model was developed to determine sufficient tugboat allocation according to some variables in ports. The simulation model was subjected to various experiments, and statistical analyses of the obtained results were performed. The relationships between the variables affecting the level of towage service were revealed.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83143559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Direct current mode neutron detection, investigation of polarization effect on 500μm single crystal CVD diamond detector, and depolarization techniques","authors":"Kaleab Ayalew","doi":"10.2172/1995761","DOIUrl":"https://doi.org/10.2172/1995761","url":null,"abstract":"","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87829465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-19DOI: 10.1177/00375497231192108
Eylül Damla Gönül-Sezer, Duygun Fatih Demirel
The relationship between military expenditures and economic productivity has taken the attention of many researchers and there exist an important number of studies approaching the topic through several techniques. However, there is no consensus among the scholars whether military expenditures trigger economic growth, productivity, and other macroeconomic indicators. Such arguments are mainly due to unclear results obtained from the existing studies, in which the complex relationships between military expenditures and macroeconomics are not fully incorporated. Considering the bidirectional and nonlinear relationships among macroeconomic indicators and complex feedback mechanisms, a system dynamics (SD) model for examining the impacts of military expenditures on economic productivity in Turkey is proposed. The proposed SD model aims to reflect the complex environment surrounding the military spending–economic productivity nexus and to analyze the feedback structures that lead to miscellaneous consequences with delays. A stock–flow model is developed to represent the complex nonlinear relationships and causalities between the variables. Data from SIPRI, the World Bank, and several local statistical sources covering the years 2009–2018 are utilized to simulate the existing case, warfare in neighbors, economic shrinkage scenarios, and the combination of the latter two. The results obtained from the scenarios suggest that short fixes such as importing military products instead of national investments give rise to chronic issues like continual dependence on foreign supply, hence, leading to decrease in overall economic growth. To the best of our knowledge, this is the first attempt to integrate SD methodology with military expenditure and economic productivity analysis.
{"title":"Examining the impacts of military expenditures on economic productivity: a system dynamics approach","authors":"Eylül Damla Gönül-Sezer, Duygun Fatih Demirel","doi":"10.1177/00375497231192108","DOIUrl":"https://doi.org/10.1177/00375497231192108","url":null,"abstract":"The relationship between military expenditures and economic productivity has taken the attention of many researchers and there exist an important number of studies approaching the topic through several techniques. However, there is no consensus among the scholars whether military expenditures trigger economic growth, productivity, and other macroeconomic indicators. Such arguments are mainly due to unclear results obtained from the existing studies, in which the complex relationships between military expenditures and macroeconomics are not fully incorporated. Considering the bidirectional and nonlinear relationships among macroeconomic indicators and complex feedback mechanisms, a system dynamics (SD) model for examining the impacts of military expenditures on economic productivity in Turkey is proposed. The proposed SD model aims to reflect the complex environment surrounding the military spending–economic productivity nexus and to analyze the feedback structures that lead to miscellaneous consequences with delays. A stock–flow model is developed to represent the complex nonlinear relationships and causalities between the variables. Data from SIPRI, the World Bank, and several local statistical sources covering the years 2009–2018 are utilized to simulate the existing case, warfare in neighbors, economic shrinkage scenarios, and the combination of the latter two. The results obtained from the scenarios suggest that short fixes such as importing military products instead of national investments give rise to chronic issues like continual dependence on foreign supply, hence, leading to decrease in overall economic growth. To the best of our knowledge, this is the first attempt to integrate SD methodology with military expenditure and economic productivity analysis.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83089671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-08DOI: 10.1177/00375497231184898
Jan de Mooij, P. Bhattacharya, Davide Dell’Anna, M. Dastani, B. Logan, S. Swarup
Agent-based modeling is increasingly being used in computational epidemiology to characterize important behavioral dimensions, such as the heterogeneity of the individual responses to interventions, when studying the spread of a disease. Existing agent-based simulation frameworks and platforms currently fall in one of two categories: those that can simulate millions of individuals with simple behaviors (e.g., based on simple state machines), and those that consider more complex and social behaviors (e.g., agents that act according to their own agenda and preferences, and deliberate about norm compliance) but, due to the computational complexity of reasoning involved, have limited scalability. In this paper, we present a novel framework that enables large-scale distributed epidemic simulations with complex behaving social agents whose decisions are based on a variety of concepts and internal attitudes such as sense, knowledge, preferences, norms, and plans. The proposed framework supports simulations with millions of such agents that can individually deliberate about their own knowledge, goals, and preferences, and can adapt their behavior based on other agents’ behaviors and on their attitude toward complying with norms. We showcase the applicability and scalability of the proposed framework by developing a model of the spread of COVID-19 in the US state of Virginia. Results illustrate that the framework can be effectively employed to simulate disease spreading with millions of complex behaving agents and investigate behavioral interventions over a period of time of months.
{"title":"A framework for modeling human behavior in large-scale agent-based epidemic simulations","authors":"Jan de Mooij, P. Bhattacharya, Davide Dell’Anna, M. Dastani, B. Logan, S. Swarup","doi":"10.1177/00375497231184898","DOIUrl":"https://doi.org/10.1177/00375497231184898","url":null,"abstract":"Agent-based modeling is increasingly being used in computational epidemiology to characterize important behavioral dimensions, such as the heterogeneity of the individual responses to interventions, when studying the spread of a disease. Existing agent-based simulation frameworks and platforms currently fall in one of two categories: those that can simulate millions of individuals with simple behaviors (e.g., based on simple state machines), and those that consider more complex and social behaviors (e.g., agents that act according to their own agenda and preferences, and deliberate about norm compliance) but, due to the computational complexity of reasoning involved, have limited scalability. In this paper, we present a novel framework that enables large-scale distributed epidemic simulations with complex behaving social agents whose decisions are based on a variety of concepts and internal attitudes such as sense, knowledge, preferences, norms, and plans. The proposed framework supports simulations with millions of such agents that can individually deliberate about their own knowledge, goals, and preferences, and can adapt their behavior based on other agents’ behaviors and on their attitude toward complying with norms. We showcase the applicability and scalability of the proposed framework by developing a model of the spread of COVID-19 in the US state of Virginia. Results illustrate that the framework can be effectively employed to simulate disease spreading with millions of complex behaving agents and investigate behavioral interventions over a period of time of months.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74378327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.1177/00375497231189285
Jinchao Chen, Haoran Zhang, Ruimeng He, Chenglie Du, Jie Cui, Xiaoying Sun
In recent years, the number of invested resources adopted in experiments of embedded applications dropped significantly as many simulation technologies are widely used. However, the efficiency of simulations is seriously influenced by some expensive and difficult-to-obtain devices. It is urgent and of great significance to build a universal simulation platform for embedded applications on general-purpose operating systems with an objective of improving the efficiency and effectiveness of system development and implementation. Since virtualization technology can greatly enhance the simulation efficiency by providing virtual models to simulate the behaviors of real devices, this paper designs and realizes a real-time simulation platform on general-purpose operating systems with the virtualization technology such that embedded applications would be correctly and efficiently debugged and tested on the general-purpose operating systems. The proposed simulation platform contains four layers named hardware resource, virtualization, virtual runtime environment, and interface adaptation, allowing dynamic debugging and testing of embedded applications without requiring the actual presence of real devices. Experiments are conducted to verify the functionalities of the proposed simulation platform, and results demonstrate that the proposed simulation platform can meet the real-time and high reliability requirements of embedded applications.
{"title":"Design and implementation of a real-time simulation platform for embedded applications on general-purpose operating systems","authors":"Jinchao Chen, Haoran Zhang, Ruimeng He, Chenglie Du, Jie Cui, Xiaoying Sun","doi":"10.1177/00375497231189285","DOIUrl":"https://doi.org/10.1177/00375497231189285","url":null,"abstract":"In recent years, the number of invested resources adopted in experiments of embedded applications dropped significantly as many simulation technologies are widely used. However, the efficiency of simulations is seriously influenced by some expensive and difficult-to-obtain devices. It is urgent and of great significance to build a universal simulation platform for embedded applications on general-purpose operating systems with an objective of improving the efficiency and effectiveness of system development and implementation. Since virtualization technology can greatly enhance the simulation efficiency by providing virtual models to simulate the behaviors of real devices, this paper designs and realizes a real-time simulation platform on general-purpose operating systems with the virtualization technology such that embedded applications would be correctly and efficiently debugged and tested on the general-purpose operating systems. The proposed simulation platform contains four layers named hardware resource, virtualization, virtual runtime environment, and interface adaptation, allowing dynamic debugging and testing of embedded applications without requiring the actual presence of real devices. Experiments are conducted to verify the functionalities of the proposed simulation platform, and results demonstrate that the proposed simulation platform can meet the real-time and high reliability requirements of embedded applications.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88966078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-19DOI: 10.1177/00375497231185358
Md Jahedul Alam, Alexandre Pinchemel, M. A. Habib, M. Caetano
This study develops a framework of pedestrian evacuation microsimulation modeling that considers pedestrians’ social-physiological behavior in assessing an airport evacuation. The study implements social force model within a simulation platform enabling the articulation of stochastic pedestrian walking behavior realistically and reliably. It performs a sensitivity analysis of pedestrian behavior parameters to identify the candidate parameters required to capture pedestrian behavior under different levels of panic conditions. The study considers the case study of the Ottawa International Airport and tests and evaluates contrasting evacuation scenarios under low panic, medium panic, and high panic situations. Results indicate that under the low panic evacuation scenario, the pedestrians yield their movements with an increase in network bottleneck, potentially exhibit cooperative behavior, and control their speed with the rise of crowd density. On the contrary, individuals in high panic evacuation scenarios exhibit aggressive behavior indicated by their average speed, which is approximately 1.15 and 3.5 times the average compared with medium panic and low panic evacuation scenarios, respectively. Results suggest that it takes 5.38 min to evacuate 1300 passengers under high panic conditions compared with 9.75 min for a low panic evacuation scenario. However, in the case of a high panic evacuation scenario, the average speed keeps increasing even with the increase in crowd density. This framework can develop and evaluate strategies for safely evacuating the airport in the case of an emergency.
{"title":"Airport evacuation under panic conditions: a microsimulation modeling applied at Ottawa International Airport","authors":"Md Jahedul Alam, Alexandre Pinchemel, M. A. Habib, M. Caetano","doi":"10.1177/00375497231185358","DOIUrl":"https://doi.org/10.1177/00375497231185358","url":null,"abstract":"This study develops a framework of pedestrian evacuation microsimulation modeling that considers pedestrians’ social-physiological behavior in assessing an airport evacuation. The study implements social force model within a simulation platform enabling the articulation of stochastic pedestrian walking behavior realistically and reliably. It performs a sensitivity analysis of pedestrian behavior parameters to identify the candidate parameters required to capture pedestrian behavior under different levels of panic conditions. The study considers the case study of the Ottawa International Airport and tests and evaluates contrasting evacuation scenarios under low panic, medium panic, and high panic situations. Results indicate that under the low panic evacuation scenario, the pedestrians yield their movements with an increase in network bottleneck, potentially exhibit cooperative behavior, and control their speed with the rise of crowd density. On the contrary, individuals in high panic evacuation scenarios exhibit aggressive behavior indicated by their average speed, which is approximately 1.15 and 3.5 times the average compared with medium panic and low panic evacuation scenarios, respectively. Results suggest that it takes 5.38 min to evacuate 1300 passengers under high panic conditions compared with 9.75 min for a low panic evacuation scenario. However, in the case of a high panic evacuation scenario, the average speed keeps increasing even with the increase in crowd density. This framework can develop and evaluate strategies for safely evacuating the airport in the case of an emergency.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74340296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.1177/00375497231183722
Fatima-Zahra Sahlaoui, Lina Aboueljinane, M. Lebbar
Simulation-based metamodels or surrogate models are simplified models that capture the relationship between inputs and outputs of the simulation model. The analytical expression of metamodels is defined using a sample of input/output points obtained from the simulation model. This analytical expression is then embedded in an optimization process that usually provides solutions much faster than other simulation-based optimization techniques such as metaheuristics or mathematical modeling. The goal of this paper is to describe the simulation-based metamodeling approach and to provide a thorough review of the literature on its applications to emergency healthcare systems. For this purpose, we examine the recent literature (journals and conference proceedings) published in the last 15 years (2008–2022). Finally, we identify findings and avenues of research in simulation-based metamodeling that deserve special attention from the scientific community and allow the potential of this approach to be used for better decision-making in emergency healthcare.
{"title":"A review on simulation-based metamodeling in emergency healthcare: methodology, applications, and future challenges","authors":"Fatima-Zahra Sahlaoui, Lina Aboueljinane, M. Lebbar","doi":"10.1177/00375497231183722","DOIUrl":"https://doi.org/10.1177/00375497231183722","url":null,"abstract":"Simulation-based metamodels or surrogate models are simplified models that capture the relationship between inputs and outputs of the simulation model. The analytical expression of metamodels is defined using a sample of input/output points obtained from the simulation model. This analytical expression is then embedded in an optimization process that usually provides solutions much faster than other simulation-based optimization techniques such as metaheuristics or mathematical modeling. The goal of this paper is to describe the simulation-based metamodeling approach and to provide a thorough review of the literature on its applications to emergency healthcare systems. For this purpose, we examine the recent literature (journals and conference proceedings) published in the last 15 years (2008–2022). Finally, we identify findings and avenues of research in simulation-based metamodeling that deserve special attention from the scientific community and allow the potential of this approach to be used for better decision-making in emergency healthcare.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87542059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.1177/00375497231184246
J. L. Risco-Martín, Segundo Esteban, Jesús Chacón, Gonzalo Carazo-Barbero, E. Besada-Portas, J. A. López-Orozco
Harmful algal and cyanobacterial blooms (HABs), occurring in inland and maritime waters, pose threats to natural environments by producing toxins that affect human and animal health. In the past, HABs have been assessed mainly by the manual collection and subsequent analysis of water samples and occasionally by automatic instruments that acquire information from fixed locations. These procedures do not provide data with the desirable spatial and temporal resolution to anticipate the formation of HABs. Hence, new tools and technologies are needed to efficiently detect, characterize and respond to HABs that threaten water quality. It is essential nowadays when the world’s water supply is under tremendous pressure because of climate change, overexploitation, and pollution. This paper introduces Discrete Event System Specification-BLOOM, a novel framework for real-time monitoring and management of HABs. Its purpose is to support high-performance hazard detection with model-based system engineering and cyber-physical systems infrastructure for dynamic environments.
{"title":"Simulation-driven engineering for the management of harmful algal and cyanobacterial blooms","authors":"J. L. Risco-Martín, Segundo Esteban, Jesús Chacón, Gonzalo Carazo-Barbero, E. Besada-Portas, J. A. López-Orozco","doi":"10.1177/00375497231184246","DOIUrl":"https://doi.org/10.1177/00375497231184246","url":null,"abstract":"Harmful algal and cyanobacterial blooms (HABs), occurring in inland and maritime waters, pose threats to natural environments by producing toxins that affect human and animal health. In the past, HABs have been assessed mainly by the manual collection and subsequent analysis of water samples and occasionally by automatic instruments that acquire information from fixed locations. These procedures do not provide data with the desirable spatial and temporal resolution to anticipate the formation of HABs. Hence, new tools and technologies are needed to efficiently detect, characterize and respond to HABs that threaten water quality. It is essential nowadays when the world’s water supply is under tremendous pressure because of climate change, overexploitation, and pollution. This paper introduces Discrete Event System Specification-BLOOM, a novel framework for real-time monitoring and management of HABs. Its purpose is to support high-performance hazard detection with model-based system engineering and cyber-physical systems infrastructure for dynamic environments.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89235602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-24DOI: 10.1177/00375497231180956
Shubh Shrey, B. Kothavale, Mangesh Saraf, Hrishikesh Kakade, Sujay Shelke, K. Kusupudi
This article provides an overview of the smooth particle hydrodynamics (SPH) approach and its mathematical modeling. SPH is a numerical technique based on a mesh-free Lagrangian scheme for evaluating the continuum mechanics problems. This method is suitable in the case of continuum objects undergoing large deformation, as conventional finite element methods are unreliable due to mesh failure and convergence issues. It is a widely used approach in the field of astrophysics, fluid mechanics, structural mechanics, soil mechanics, automobiles, and so on. A numerical example is also considered in this research paper to demonstrate the applicability of the method. The simulation process was achieved using LS-Dyna explicit solver software, and plots related to cutting and thrust forces, von Mises stress, plastic strain, temperature distribution, and so on, were obtained. Also, the effect of Time-Scaling Factor (TSSFAC) on SPH simulations was observed in this research.
{"title":"Smooth particle hydrodynamics: a meshless approach for structural mechanics","authors":"Shubh Shrey, B. Kothavale, Mangesh Saraf, Hrishikesh Kakade, Sujay Shelke, K. Kusupudi","doi":"10.1177/00375497231180956","DOIUrl":"https://doi.org/10.1177/00375497231180956","url":null,"abstract":"This article provides an overview of the smooth particle hydrodynamics (SPH) approach and its mathematical modeling. SPH is a numerical technique based on a mesh-free Lagrangian scheme for evaluating the continuum mechanics problems. This method is suitable in the case of continuum objects undergoing large deformation, as conventional finite element methods are unreliable due to mesh failure and convergence issues. It is a widely used approach in the field of astrophysics, fluid mechanics, structural mechanics, soil mechanics, automobiles, and so on. A numerical example is also considered in this research paper to demonstrate the applicability of the method. The simulation process was achieved using LS-Dyna explicit solver software, and plots related to cutting and thrust forces, von Mises stress, plastic strain, temperature distribution, and so on, were obtained. Also, the effect of Time-Scaling Factor (TSSFAC) on SPH simulations was observed in this research.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89758197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-19DOI: 10.1177/00375497231176085
Ali Ayadi, C. Frydman, Wissame Laddada, I. Imbert, C. Zanni-Merk, L. Soualmia
This article presents an hybrid and hierarchical model in which two modeling and simulation approaches, discrete event system specification simulation (DEVS) and semantic technologies, were used together in order to help in the analysis of a major healthcare problem, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Indeed, the complexity of the SARS-CoV-2 replication process, and the range of hierarchical scales over which it interacts with cellular components (extending from genomic and transcriptomic to proteomic and metabolomic scales), and the intricate way in which they are interwoven, make its understanding very challenging. It is therefore crucial to model the different scales of the replication process, by taking into account all interactions with the infected cell. By combining the advantages of both DEVS simulation and ontological modeling, we propose a hierarchical ontology-based DEVS simulation model of the SARS-CoV-2 viral replication at both the micro-molecular (proteomic and metabolomic) and macro-molecular (genomic and transcriptomic) scales. First, we demonstrate the usefulness of combining DEVS simulation and semantic technologies in a common modeling framework to face the complexity of the SARS-CoV-2 viral replication at different scales. Second, the modeling and simulation of the SARS-CoV-2 replication process on different levels provide valuable information on the different stages of the virus’s life cycle and lays the foundation for a system to anticipate future mutations selected by the virus.
{"title":"Combining DEVS simulation and ontological modeling for hierarchical analysis of the SARS-CoV-2 replication","authors":"Ali Ayadi, C. Frydman, Wissame Laddada, I. Imbert, C. Zanni-Merk, L. Soualmia","doi":"10.1177/00375497231176085","DOIUrl":"https://doi.org/10.1177/00375497231176085","url":null,"abstract":"This article presents an hybrid and hierarchical model in which two modeling and simulation approaches, discrete event system specification simulation (DEVS) and semantic technologies, were used together in order to help in the analysis of a major healthcare problem, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Indeed, the complexity of the SARS-CoV-2 replication process, and the range of hierarchical scales over which it interacts with cellular components (extending from genomic and transcriptomic to proteomic and metabolomic scales), and the intricate way in which they are interwoven, make its understanding very challenging. It is therefore crucial to model the different scales of the replication process, by taking into account all interactions with the infected cell. By combining the advantages of both DEVS simulation and ontological modeling, we propose a hierarchical ontology-based DEVS simulation model of the SARS-CoV-2 viral replication at both the micro-molecular (proteomic and metabolomic) and macro-molecular (genomic and transcriptomic) scales. First, we demonstrate the usefulness of combining DEVS simulation and semantic technologies in a common modeling framework to face the complexity of the SARS-CoV-2 viral replication at different scales. Second, the modeling and simulation of the SARS-CoV-2 replication process on different levels provide valuable information on the different stages of the virus’s life cycle and lays the foundation for a system to anticipate future mutations selected by the virus.","PeriodicalId":49516,"journal":{"name":"Simulation-Transactions of the Society for Modeling and Simulation International","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84214991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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