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Personality as a key driver of oral health behaviour: evidence from the Northern Finland Birth Cohort. 性格是口腔健康行为的关键驱动因素:来自芬兰北部出生队列的证据。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-15 DOI: 10.1177/14034948261426166
Evangelos Mourelatos, Jaakko Simonen, Marja-Liisa Laitala, Saujanya Karki

Aims: The existing literature lacks sufficient evidence concerning the role of personality traits in oral behaviour and their effects on oral health status (dental plaque, and dental caries) and dental visits. The aim of this study was to investigate the association between personality traits and oral health behaviour (OHB) in the adult Finnish population.

Methods: This study utilised data collected from the Northern Finland Birth Cohort 1986 individuals who participated in all the follow-ups (n = 1807). Data were collected during pregnancy and later during follow-ups conducted at 1 year, 7-8 years, 15-16 years and 33-35 years using questionnaires and clinical examinations. Oral health status and number of dental visits collected in the last follow-up were considered as dependent variables. The explanatory variables included personality traits, educational background, employment, annual income, and lifestyle choices. A recursive bivariate probit model was used to model oral health status (dental plaque, and dental caries) while considering dental care utilisation.

Results: Personality traits were associated with OHB (accumulation of dental plaque and regular dental visits). Individuals with a high degree of openness had a 13% lower probability of having teeth with dental caries. Similarly, highly neurotic individuals had a 5% lower probability of having teeth with visible dental plaque and also had a higher probability of dental visiting.

Conclusions: Personality traits are associated with OHB among young adults Finns. Policies aimed at improving dental health education and mitigating common risk factors are essential to promote oral health.

目的:关于人格特质在口腔行为中的作用及其对口腔健康状况(牙菌斑和龋齿)和牙科就诊的影响,现有文献缺乏足够的证据。本研究的目的是调查芬兰成年人的人格特征与口腔健康行为(OHB)之间的关系。方法:本研究使用了来自芬兰北部出生队列1986人的数据,这些人参加了所有随访(n = 1807)。数据收集于怀孕期间,并在1岁、7-8岁、15-16岁和33-35岁时通过问卷调查和临床检查进行随访。在最后一次随访中收集的口腔健康状况和牙科就诊次数被视为因变量。解释变量包括性格特征、教育背景、就业、年收入和生活方式选择。在考虑牙科保健利用的情况下,使用递归双变量概率模型来模拟口腔健康状况(牙菌斑和龋齿)。结果:人格特征与OHB(牙菌斑积累和定期看牙)相关。牙齿高度开放的人患龋齿的可能性要低13%。同样,高度神经质的人牙齿上有可见牙菌斑的可能性要低5%,去看牙医的可能性也要高一些。结论:芬兰人的人格特征与OHB相关。旨在改善牙齿健康教育和减少常见危险因素的政策对促进口腔健康至关重要。
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引用次数: 0
Evaluating the performance of a custom GPT in full text screening of a systematic review. 在系统综述的全文筛选中评估自定义GPT的性能。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-13 DOI: 10.1177/14034948261423410
Rachel C Davis, Saskia S List, Kendal G Chappell, Ahmed Madar, Sigrun Henjum, Espen Heen

Aim: Systematic reviewing is a time-consuming process that can be aided by artificial intelligence (AI). There are several AI options to assist with title/abstract screening, however options for full text screening are limited. The objective of this study was to evaluate the performance of a custom generative pretrained transformer (cGPT) for full text screening.

Methods: A cGPT powered by OpenAI's ChatGPT4o was tested with subsets of articles assessed in duplicate by human reviewers. Outputs from the testing subset were coded to simulate cGPT as an autonomous and an assistant reviewer. Cohen's kappa was used to assess interrater agreement.

Results: For the inclusion/exclusion decision, the human-human kappa scores ranged from 0.87 to 0.96, exceeding the ranges of kappa scores for autonomous cGPT-human pairings (0.59 to 0.67) and assistant cGPT-human pairings (0.62 to 0.72). For exclusion reason classification, the human-human kappa scores ranged from 0.71 to 0.78, exceeding the ranges of kappa scores for autonomous cGPT-human pairings (0.47 to 0.53) and assistant cGPT-human pairings (0.52 to 0.63).

Conclusions: The assistant cGPT outperformed the autonomous cGPT. An assistant cGPT could speed up systematic reviewing in a sufficiently reliable manner, however, further research is needed to establish standardized thresholds for practical use. Improved speed of systematic reviewing has implications for directing timely public health policy decisions.

目的:系统审查是一个耗时的过程,可以通过人工智能(AI)来辅助。有几个AI选项可以帮助进行标题/摘要筛选,但全文筛选的选项有限。本研究的目的是评估用于全文筛选的自定义生成预训练转换器(cGPT)的性能。方法:由OpenAI的chatgpt40提供支持的cGPT使用由人工审稿人重复评估的文章子集进行测试。对测试子集的输出进行编码,以模拟cGPT作为自主审阅者和助理审阅者。科恩kappa被用来评估口译员之间的一致性。结果:对于纳入/排除决策,人-人kappa评分范围为0.87 ~ 0.96,超过了自主cgpt -人配对(0.59 ~ 0.67)和辅助cgpt -人配对(0.62 ~ 0.72)的kappa评分范围。排除原因分类中,人-人kappa评分范围为0.71 ~ 0.78,超过了自主配对(0.47 ~ 0.53)和辅助配对(0.52 ~ 0.63)的kappa评分范围。结论:辅助cGPT优于自主cGPT。辅助cpt可以以足够可靠的方式加速系统审查,但是,需要进一步研究以确定实际使用的标准化阈值。提高系统审查的速度对指导及时作出公共卫生政策决定具有重要意义。
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引用次数: 0
Risk and cause of overdose death after exposure to dispensed opioid analgesics. 配用阿片类镇痛药暴露后过量死亡的风险和原因。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-12 DOI: 10.1177/14034948261424666
Ellen J Amundsen, Svetlana Skurtveit, Ingvild Odsbu

Aims: Overdose deaths have been increasing in parts of Europe, including Norway, where opioid analgesics have been the leading cause since 2016. This study quantifies the risk of overdose death following exposure to dispensed opioid analgesics, stratified by sex and age, and examines associated causes of death.

Methods: Nationwide data from 2010 to 2018 on overdose deaths were obtained from the Norwegian Cause of Death Registry and linked with the Norwegian Prescription Database to identify prior opioid analgesic dispensations. Aggregated prescription data and population figures from Statistics Norway were also used.

Results: From 2010 to 2018, 42% of individuals who died from an overdose had been dispensed opioid analgesics in the previous year. Among those dispensed strong opioid analgesics, the overdose death rate was low but exceeded the population death rate among men aged 20-49 and women aged 20-39 years. The rate was higher in men and remained stable over time. Opioids other than heroin or methadone were listed as the cause of death in 62% of cases with prior dispensed opioid analgesics, compared with 24% among those without.

Conclusions: The risk of overdose deaths following exposure to strong opioid analgesics was low but higher than population death rates for men under 50 and women under 40 years. Preventive strategies based on risk markers such as sex, age and opioid analgesic strengths, combined with other known risk markers, can help guide safer prescription of opioid analgesics and reduce overdose death.

目的:在包括挪威在内的欧洲部分地区,过量死亡人数一直在增加,自2016年以来,阿片类镇痛药一直是主要原因。本研究量化了暴露于配药阿片类镇痛药后过量死亡的风险,按性别和年龄分层,并检查了相关的死亡原因。方法:从挪威死因登记处获得2010年至2018年全国过量死亡数据,并与挪威处方数据库相关联,以确定先前的阿片类镇痛药配剂。还使用了挪威统计局的综合处方数据和人口数字。结果:从2010年到2018年,42%因过量服用阿片类镇痛药而死亡的人在前一年服用了阿片类镇痛药。在使用强阿片类镇痛药的患者中,过量死亡率较低,但超过了20-49岁男性和20-39岁女性的人口死亡率。男性的比例更高,并且随着时间的推移保持稳定。在之前使用过阿片类镇痛药的病例中,62%的病例将海洛因或美沙酮以外的阿片类药物列为死亡原因,而在没有使用过阿片类镇痛药的病例中,这一比例为24%。结论:暴露于强效阿片类镇痛药后过量死亡的风险较低,但高于50岁以下男性和40岁以下女性的人口死亡率。基于性别、年龄和阿片类镇痛药强度等风险标志的预防战略,结合其他已知风险标志,可以帮助指导更安全的阿片类镇痛药处方,并减少过量死亡。
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引用次数: 0
Interventions to improve work ability and reduce early exit from the labor market: a systematic review and meta-analysis among midlife and older workers. 提高工作能力和减少过早退出劳动力市场的干预措施:对中年和老年工人的系统回顾和荟萃分析。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-11 DOI: 10.1177/14034948261422934
Joonas Poutanen, Tea Lallukka, Matti Joensuu, Eija Haukka, Jenni Ervasti, Mikko Härmä, Rahman Shiri

Aim: To identify effective interventions designed to improve work ability and reduce early exit from the labor market of midlife and older workers.

Method: Searches were conducted in PubMed, Cochrane Library, Scopus, Web of Science, and PsycInfo up to February 17, 2025, focusing on studies aimed at improving work ability and associated conditions (work productivity, work engagement, job performance, and work capacity) and reducing early exit from the labor market among participants aged ⩾40 years. Two reviewers evaluated the quality of studies. The effectiveness of interventions was evaluated using meta-analysis and, when not feasible, qualitative synthesis.

Results: Of 17,505 publications, 41 studies were included, comprising 14 randomized controlled trials (RCTs, n = 4123) and 27 non-randomized studies (n = 4,616,452). Meta-analysis of RCTs showed that aerobic or strengthening exercises modestly improved work ability (pooled standardized mean difference 0.26, 95% CI 0.08-0.44). Qualitative synthesis indicated cognitive behavioral therapy (CBT) reduced productivity loss in workers with chronic health conditions. A meta-analysis of non-randomized studies showed policy reforms raising the eligible retirement age increased employment by 12 percentage points (pps) (95% CI 7-17) and decreased retirement by 29 pps (95% CI 8-50), but increased disability benefits by 6 pps (95% CI 1-11), unemployment by 7 pps (95% CI 2-12), and economic inactivity by 6 pps (95% CI 5-8). Policy reforms tightening unemployment benefit requirements increased employment and reduced unemployment, but increased disability benefits.

Conclusions: Exercise improved work ability and CBT reduced productivity loss. Regulatory actions on retirement age and unemployment benefits were associated with higher work participation.

目的:找出有效的干预措施,旨在提高工作能力和减少过早退出劳动力市场的中老年工人。方法:截至2025年2月17日,在PubMed, Cochrane Library, Scopus, Web of Science和PsycInfo中进行检索,重点关注旨在提高工作能力和相关条件(工作生产率,工作参与度,工作绩效和工作能力)的研究,并减少年龄大于或小于40岁的参与者过早退出劳动力市场的情况。两位审稿人评估了研究的质量。干预措施的有效性采用荟萃分析进行评估,如果不可行,则采用定性综合。结果:在17,505篇出版物中,纳入41项研究,包括14项随机对照试验(rct, n = 4123)和27项非随机研究(n = 4,616,452)。随机对照试验的荟萃分析显示,有氧或强化运动适度提高了工作能力(合并标准化平均差为0.26,95% CI为0.08-0.44)。定性综合表明,认知行为疗法(CBT)减少了慢性健康状况工人的生产力损失。一项非随机研究的荟萃分析显示,提高合格退休年龄的政策改革使就业增加了12个百分点(95% CI 7-17),使退休人数减少了29个百分点(95% CI 8-50),但使残疾福利增加了6个百分点(95% CI 1-11),失业率增加了7个百分点(95% CI 2-12),经济不活动增加了6个百分点(95% CI 5-8)。收紧失业救济金要求的政策改革增加了就业,减少了失业率,但增加了残疾救济金。结论:运动提高了工作能力,CBT减少了生产力损失。对退休年龄和失业救济金的监管行动与更高的工作参与率有关。
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引用次数: 0
Voices from the margins: A qualitative study exploring components influencing psychosocial health and wellbeing among gender minority forced migrants. 来自边缘的声音:一项探讨影响性别少数群体被迫移徙者心理社会健康和福祉因素的定性研究。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2024-12-10 DOI: 10.1177/14034948241301874
Maria Gottvall, Rummage Isaac, Osszián Péter-Szabó, Ronah Ainembabazi, Tommy Carlsson

Aims: To explore the components that influence health and wellbeing of gender minority forced migrants residing in Sweden.

Methods: Qualitative exploratory study based on semi-structured interviews with gender minority forced migrants recruited through a combination of convenience, purposeful and snowball sampling. Guided by the levels in the social ecological model, transcripts were analysed with systematic text condensation in a collaborative process between experts by lived experience, researchers and clinical psychologist.

Results: Participants expressed resilience and hope about their future. Loneliness was a major issue contributing to health burdens and peer support was highly appreciated. Barriers hindering access to health services and judgemental behaviours among health professionals were described. Affirming support through empathy, trust, safety, confidentiality, continuity and respect was highlighted as essential in health services. While societal openness and safety for gender minority individuals was appreciated, participants faced an uncertain asylum process and unmet basic needs.

Conclusions: Gender minority forced migrants show resilience and appreciate the newfound societal safety. However, they find themselves in the margins of society and encounter various multi-layered challenges. Loneliness is a public health concern that could be addressed through peer support, which is highly desired and valued. Ensuring access to affirming health services should be a prioritized area for researchers, professionals, stakeholders and policy-makers.

目的:探讨影响居住在瑞典的性别少数被迫移民的健康和福祉的组成部分。方法:采用便利性、目的性和滚雪球抽样相结合的半结构化访谈方法,对招募的性别少数民族强迫流动人口进行定性探索性研究。在社会生态模型层次的指导下,在生活经验专家、研究者和临床心理学家的协作过程中,对转录本进行了系统的文本浓缩分析。结果:参与者表达了对未来的韧性和希望。孤独是造成健康负担的一个主要问题,人们高度赞赏同伴的支持。描述了妨碍获得保健服务的障碍和保健专业人员的判断行为。会议强调,通过同情、信任、安全、保密、连续性和尊重来肯定支持是保健服务的关键。虽然对性别少数群体的社会开放和安全表示赞赏,但参与者面临着不确定的庇护程序和未满足的基本需求。结论:少数性别被迫移民表现出适应力,并对新发现的社会安全感到满意。然而,他们发现自己处于社会的边缘,面临着各种多层次的挑战。孤独是一个公共健康问题,可以通过同伴支持来解决,这是非常需要和重视的。确保获得肯定性卫生服务应成为研究人员、专业人员、利益攸关方和决策者的优先领域。
{"title":"Voices from the margins: A qualitative study exploring components influencing psychosocial health and wellbeing among gender minority forced migrants.","authors":"Maria Gottvall, Rummage Isaac, Osszián Péter-Szabó, Ronah Ainembabazi, Tommy Carlsson","doi":"10.1177/14034948241301874","DOIUrl":"10.1177/14034948241301874","url":null,"abstract":"<p><strong>Aims: </strong>To explore the components that influence health and wellbeing of gender minority forced migrants residing in Sweden.</p><p><strong>Methods: </strong>Qualitative exploratory study based on semi-structured interviews with gender minority forced migrants recruited through a combination of convenience, purposeful and snowball sampling. Guided by the levels in the social ecological model, transcripts were analysed with systematic text condensation in a collaborative process between experts by lived experience, researchers and clinical psychologist.</p><p><strong>Results: </strong>Participants expressed resilience and hope about their future. Loneliness was a major issue contributing to health burdens and peer support was highly appreciated. Barriers hindering access to health services and judgemental behaviours among health professionals were described. Affirming support through empathy, trust, safety, confidentiality, continuity and respect was highlighted as essential in health services. While societal openness and safety for gender minority individuals was appreciated, participants faced an uncertain asylum process and unmet basic needs.</p><p><strong>Conclusions: </strong>Gender minority forced migrants show resilience and appreciate the newfound societal safety. However, they find themselves in the margins of society and encounter various multi-layered challenges. Loneliness is a public health concern that could be addressed through peer support, which is highly desired and valued. Ensuring access to affirming health services should be a prioritized area for researchers, professionals, stakeholders and policy-makers.</p>","PeriodicalId":49568,"journal":{"name":"Scandinavian Journal of Public Health","volume":" ","pages":"99-104"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forecasting the burden of hip fracture in Norway towards 2050 by educational level: The Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). 根据教育水平预测2050年挪威髋部骨折负担:挪威骨质疏松症流行病学研究(NOREPOS)。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-03-12 DOI: 10.1177/14034948251325760
Helena K Kjeldgaard, Tone K Omsland, Vegard F Skirbekk, Martin O'flaherty, Haakon E Meyer, Kristin Holvik

Aims: Hip fracture burden is expected to increase due to the ageing population. Given that hip fracture incidence differs by educational attainment, and that a shift in the older population's educational level will manifest itself in coming decades, we investigated future hip fracture trends in Norway and their variation by attained educational level.

Methods: Estimated annual hip fracture numbers in the population aged 50+ years in 2020-2050 were based on information from the Norwegian Epidemiologic Osteoporosis Studies hip fracture database and official population projections from Statistics Norway. Projected educational attainment was obtained from the Wittgenstein Centre for Demography and Global Human Capital. We explored two scenarios: first, assuming that the observed 2019 rates remain constant until 2050, and second, assuming a continuing rate of decline corresponding to that observed during 1999-2019.

Results: The projections showed that the annual number of hip fractures will increase by 91% in women and 131% in men given constant sex- and age-specific rates, and by 27% in women and 66% in men given declining rates. The majority of hip fractures are expected in the group with secondary education, however, the numbers will increase steeply in people with tertiary education due to the temporal shift in educational attainment.

Conclusions: The annual number of hip fractures may double by 2050, placing high demands on the healthcare services. The majority of hip fractures are projected to occur in people with secondary and tertiary education. It is vital to intensify preventive efforts, not least in the high-risk populations.

目的:由于人口老龄化,髋部骨折负担预计会增加。鉴于髋部骨折的发生率因受教育程度而异,并且老年人口受教育水平的变化将在未来几十年显现出来,我们调查了挪威未来髋部骨折的趋势及其受教育程度的变化。方法:根据挪威骨质疏松症流行病学研究髋部骨折数据库的信息和挪威统计局的官方人口预测,估计2020-2050年50岁以上人群每年髋部骨折数量。预计受教育程度数据来自维特根斯坦人口与全球人力资本中心。我们探讨了两种情景:第一,假设观察到的2019年的速度保持不变,直到2050年;第二,假设持续下降的速度与1999-2019年观察到的速度相对应。结果:预测显示,如果特定性别和年龄的发生率不变,女性髋部骨折的年发生率将增加91%,男性髋部骨折的年发生率将增加131%;如果发病率下降,女性髋部骨折的年发生率将增加27%,男性髋部骨折的年发生率将增加66%。大多数髋部骨折预计发生在受过中等教育的人群中,然而,由于受教育程度的时间变化,受过高等教育的人群中髋部骨折的数量将急剧增加。结论:到2050年,每年髋部骨折的数量可能翻一番,对医疗保健服务提出了很高的要求。大多数髋部骨折预计发生在受过中等和高等教育的人群中。加强预防工作至关重要,尤其是在高危人群中。
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引用次数: 0
Trends in depression treatment of persons applying for disability pension due to depression: a register-based retrospective study from Finland. 因抑郁症申请伤残养恤金者的抑郁症治疗趋势:芬兰一项基于登记的回顾性研究。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 DOI: 10.1177/14034948261422954
Tero Kujanpää, Sauli Jäppinen, Kirsi Suominen, Veera Pohjolainen, Riitta Luoto

Aim: To examine trends in the treatment and rehabilitation of depression prior to disability pension application due to depression.

Methods: This retrospective register-based study included 30,105 applicants for disability pension due to depression, and it is based on data from the Social Insurance Institution of Finland (Kela). The trends in antidepressant purchases and rehabilitation measures during the year preceding the application were analysed for 2010-2019 using linear regression analysis, with analysis of covariance to assess the interactions of age- and sex-based population groups with these trends.

Results: A stable proportion of approximately 1 in 10 (9.2%-12.2%) applicants had had neither antidepressant purchases nor psychotherapy in the preceding year, with no statistically significant trend (p < 0.05). The proportion of applicants with a history of antidepressant use decreased slightly from 90.3% to 87.5%. However, the proportion of applicants with a history of psychotherapy or both psychotherapy and antidepressants doubled over the same period (from 6.1% to 13.5% and from 5.6% to 11.7%, respectively). Annually, estimated average antidepressant use declined by 0.25 percentage points, psychotherapy increased by 0.90 percentage points, and combined treatment increased by 0.75 percentage points, all statistically significant. A statistically significant interaction in psychotherapy trends was observed in population groups based on sex and age. The highest proportion of applicants receiving psychotherapy was among females under the age of 40.

Conclusions: The proportion of applicants for disability pension due to depression receiving psychotherapy has increased over time. However, most applicants, particularly older males, continue to receive only antidepressants and no rehabilitation.

目的:探讨因抑郁症申请伤残抚恤金前抑郁症的治疗和康复趋势。方法:基于芬兰社会保险机构(Kela)的数据,本研究以回顾性登记为基础,纳入30,105名因抑郁症申请残疾养老金的申请人。使用线性回归分析分析了2010-2019年申请抗抑郁药前一年的购买趋势和康复措施,并使用协方差分析来评估基于年龄和性别的人群与这些趋势的相互作用。结果:约1 / 10(9.2% ~ 12.2%)的申请者在前一年既没有购买过抗抑郁药,也没有接受过心理治疗,这一比例较为稳定,无统计学意义(p < 0.05)。有抗抑郁药物使用史的申请人比例略有下降,从90.3%降至87.5%。然而,有心理治疗史或同时服用心理治疗和抗抑郁药物的申请人比例在同一时期翻了一番(分别从6.1%增至13.5%和从5.6%增至11.7%)。每年,估计平均抗抑郁药的使用下降了0.25个百分点,心理治疗增加了0.90个百分点,联合治疗增加了0.75个百分点,这些都具有统计学意义。在基于性别和年龄的人群中观察到心理治疗趋势的统计显着相互作用。接受心理治疗的申请者比例最高的是40岁以下的女性。结论:领取伤残抚恤金的抑郁症患者接受心理治疗的比例随着时间的推移而增加。然而,大多数申请人,特别是老年男性,仍然只接受抗抑郁药,没有康复治疗。
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引用次数: 0
Evaluating mammography screening in observational cohort designs: the importance of avoiding lead time bias. 在观察性队列设计中评估乳腺放射摄影筛查:避免准备时间偏差的重要性。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2024-10-27 DOI: 10.1177/14034948241288136
Eeva-Liisa Røssell, Mette Lise Lousdal, Jakob H Viuff, Henrik Støvring

Aims: To investigate the potential lead time bias of the evaluation model (extended follow-up for women diagnosed with breast cancer) used to evaluate mammography screening in a recent Danish study. This model was compared with two traditional models.

Methods: We retrieved data on women diagnosed with breast cancer in each county of Norway from 1986 to 2016. In a population-based open cohort study, the change in incidence-based mortality (IBM) was estimated by relative rate ratios comparing a screening period with a historical period for each of three age groups: women eligible for screening and younger and older ineligible women. We applied the evaluation model, and for comparison two traditional IBM models from a recent Norwegian study: one without extended follow-up and no possibility of lead time bias and one with extended follow-up irrespective of diagnosis, possibly diluting any screening effect.

Results: The evaluation model estimated an extra 11% reduction in breast cancer mortality among the screening eligible relative to ineligible women. However, this result could largely be ascribed to lead time bias inflated by overdiagnosis and a decreasing mortality from other causes among eligible women. A reduction in breast cancer mortality was observed for both eligible and younger and older ineligible women across models, and relative rate ratios close to 1 were obtained using the two traditional IBM models, indicating no effect of screening on breast cancer mortality.

Conclusions: Two models without lead time bias found no reduction in breast cancer mortality, whereas the evaluation model estimated a reduction attributable to lead time bias.

目的:调查丹麦最近一项研究中用于评估乳腺 X 线照相筛查的评估模型(对确诊为乳腺癌的妇女延长随访时间)的潜在提前期偏差。该模型与两种传统模型进行了比较:我们检索了1986年至2016年挪威各郡确诊乳腺癌妇女的数据。在一项以人口为基础的开放式队列研究中,通过比较筛查期和历史期三个年龄组(符合筛查条件的妇女、年轻和年长的不符合条件的妇女)中每个年龄组的相对比率,估算了基于发病率的死亡率(IBM)的变化。我们使用了评估模型以及挪威最近一项研究中的两个传统 IBM 模型进行比较:一个是没有延长随访时间且不可能存在前导时间偏差的模型,另一个是无论诊断与否均延长随访时间且可能淡化筛查效果的模型:评估模型估计,与不符合筛查条件的妇女相比,符合筛查条件的妇女的乳腺癌死亡率额外降低了 11%。然而,这一结果在很大程度上可归因于过度诊断造成的准备时间偏差,以及符合筛查条件的妇女因其他原因导致的死亡率下降。在不同的模型中,都观察到符合条件的妇女和年龄较小、年龄较大的不符合条件的妇女的乳腺癌死亡率都有所下降,使用两个传统的 IBM 模型得到的相对比率接近 1,表明筛查对乳腺癌死亡率没有影响:结论:两个没有前导时间偏差的模型没有发现乳腺癌死亡率下降,而评估模型估计前导时间偏差导致了乳腺癌死亡率下降。
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引用次数: 0
Vitamin D status in the Faroe Islands: insights from the FarGen 2 cohort. 法罗群岛的维生素D状况:来自FarGen 2队列的见解。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-03-12 DOI: 10.1177/14034948251323196
Ragnhild L Jacobsen, Olivia Gray, Laura Yerges-Armstrong, Melissa Hendershott, Leivur N Lydersen, Katrin D Apol, Herborg L Johannesen, Torkil Á Steig, Kaja Wasik, Noomi O Gregersen

Background: The aim of this study was to investigate overall vitamin D status in the Faroese population and assess the correlation between vitamin D levels and various sociodemographic and anthropometric factors, including sex, age, exercise, alcohol and tobacco consumption, BMI, body fat percentage, and seasonal variations. To the best of our knowledge, this is the first study of vitamin D levels across all adult age groups within the Faroese population.

Methods: P25-hydroxyvitamin D concentrations, anthropometric measurements and questionnaires from 1748 individuals enrolled in the FarGen 2 cohort were collected. Statistical analyses were performed to characterise the distribution and correlates of vitamin D concentration in the population.

Results: We observed a high sufficiency of vitamin D in the FarGen cohort, with 74.3% of the cohort having P-25-hydroxyvitamin D levels exceeding the recommended concentration of 50 nmol/l, and only 3.3% having a vitamin D deficiency (<25 nmol/l). The deficiency was mostly observed in younger age groups. Our results indicated significant seasonal fluctuations in vitamin D levels, as well as significant correlations between vitamin D levels, age, sex, BMI, and physical activity.

Conclusions: Although the study suggests previous interventions have had a positive impact on vitamin D levels among the elderly, our findings emphasise the importance of enhancing awareness about vitamin D supplementation, promoting physical activity and encouraging consumption of vitamin D-rich foods. Such approaches could significantly advance public health initiatives related to vitamin D and general health within the Faroese population.

背景:本研究的目的是调查在法罗群岛人口中维生素D的总体状况,并评估维生素D水平与各种社会人口学和人体测量学因素之间的相关性,包括性别、年龄、运动、酒精和烟草消费、BMI、体脂率和季节变化。据我们所知,这是第一次在法罗群岛所有成年人群中进行维生素D水平的研究。方法:收集FarGen 2队列中1748人的p25 -羟基维生素D浓度、人体测量数据和问卷。对人群中维生素D浓度的分布及其相关性进行了统计分析。结果:我们在FarGen队列中观察到维生素D的高充足率,74.3%的队列p -25-羟基维生素D水平超过50 nmol/l的推荐浓度,只有3.3%的人维生素D缺乏(结论:尽管研究表明,先前的干预措施对老年人的维生素D水平有积极影响,但我们的研究结果强调了提高对维生素D补充的认识、促进身体活动和鼓励食用富含维生素D的食物的重要性。这种做法可以大大推进与维生素D和法罗人口一般健康有关的公共卫生倡议。
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引用次数: 0
Smoking and the occurrence of larynx cancer in Sweden - a population analysis. 吸烟与瑞典喉癌的发生——一项人口分析。
IF 2.1 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-03-21 DOI: 10.1177/14034948251327872
Bengt Järvholm, Per Liv, Linnea Hedman, Maréne Landström, Kjell Torén, Alex Burdorf

Aims: To study the importance of decreasing tobacco smoking on the occurrence of larynx cancer in men and women.

Methods: The incidence rates of larynx cancer in the Swedish population between 1970 and 2021 were retrieved from the Swedish Cancer Register for ages 50-84 years, stratified for sex, age and calendar year. Data on the population's smoking habits was retrieved from surveys and from taxation on the sale of cigarettes. The occurrence of larynx cancer was compared to smoking habits, sex and age. The time trends were compared between larynx and lung cancer.

Results: Over the years, Swedish men and women have had different smoking habits, especially older persons during the 1970s. In 1963, the prevalence of current smokers in women 50-69 years was 11%, while it was 46% in men. Around 2020, less than 10% of men and women in all age groups were current smokers. However, men had higher incidence rates of larynx cancer than women, even when their smoking habits were similar. For example, men and women 60-64 years of age in 2017-2021 had similar smoking habits during their life but the relative risk of larynx cancer in men compared to women was 3.3 (95% CI 1.7-4.8). However, pipe smoking was much more common in men.

Conclusions: The study indicates that other causes than cigarette smoking have an impact on the occurrence of larynx cancer in Sweden. Pipe smoking and occupational exposure to carcinogenic materials such as asbestos may be underlying causes of the difference in cancer risk between Swedish men and women.

目的:探讨减少吸烟对男性和女性喉癌发生的重要性。方法:从瑞典癌症登记处检索1970年至2021年间瑞典人口中50-84岁的喉癌发病率,按性别、年龄和日历年分层。有关人口吸烟习惯的数据来自调查和香烟销售税。将喉癌的发生与吸烟习惯、性别和年龄进行比较。比较喉癌与肺癌的时间趋势。结果:多年来,瑞典男性和女性有不同的吸烟习惯,特别是在20世纪70年代的老年人。1963年,50-69岁女性吸烟者的比例为11%,而男性为46%。在2020年左右,所有年龄组中只有不到10%的男性和女性目前是吸烟者。然而,男性的喉癌发病率高于女性,即使他们的吸烟习惯相似。例如,在2017-2021年,60-64岁的男性和女性在他们的生活中有相似的吸烟习惯,但男性患喉癌的相对风险与女性相比为3.3 (95% CI 1.7-4.8)。然而,烟斗吸烟在男性中更为常见。结论:该研究表明,除吸烟外,其他因素对瑞典喉癌的发生也有影响。抽烟斗和职业性接触石棉等致癌物质可能是瑞典男性和女性癌症风险差异的根本原因。
{"title":"Smoking and the occurrence of larynx cancer in Sweden - a population analysis.","authors":"Bengt Järvholm, Per Liv, Linnea Hedman, Maréne Landström, Kjell Torén, Alex Burdorf","doi":"10.1177/14034948251327872","DOIUrl":"10.1177/14034948251327872","url":null,"abstract":"<p><strong>Aims: </strong>To study the importance of decreasing tobacco smoking on the occurrence of larynx cancer in men and women.</p><p><strong>Methods: </strong>The incidence rates of larynx cancer in the Swedish population between 1970 and 2021 were retrieved from the Swedish Cancer Register for ages 50-84 years, stratified for sex, age and calendar year. Data on the population's smoking habits was retrieved from surveys and from taxation on the sale of cigarettes. The occurrence of larynx cancer was compared to smoking habits, sex and age. The time trends were compared between larynx and lung cancer.</p><p><strong>Results: </strong>Over the years, Swedish men and women have had different smoking habits, especially older persons during the 1970s. In 1963, the prevalence of current smokers in women 50-69 years was 11%, while it was 46% in men. Around 2020, less than 10% of men and women in all age groups were current smokers. However, men had higher incidence rates of larynx cancer than women, even when their smoking habits were similar. For example, men and women 60-64 years of age in 2017-2021 had similar smoking habits during their life but the relative risk of larynx cancer in men compared to women was 3.3 (95% CI 1.7-4.8). However, pipe smoking was much more common in men.</p><p><strong>Conclusions: </strong>\u0000 <b>The study indicates that other causes than cigarette smoking have an impact on the occurrence of larynx cancer in Sweden. Pipe smoking and occupational exposure to carcinogenic materials such as asbestos may be underlying causes of the difference in cancer risk between Swedish men and women.</b>\u0000 </p>","PeriodicalId":49568,"journal":{"name":"Scandinavian Journal of Public Health","volume":" ","pages":"157-163"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Scandinavian Journal of Public Health
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