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Biomarkers in periodontal health and diseases 牙周健康和疾病的生物标志物
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.014
Kajol Verma, Amrinder Singh
Cause of tooth loss in world is periodontitis which is a bacterial infection whose pathogenesis has complex immune response. The diagnosis is based upon patient’s periodontal health, full mouth bleeding score, full mouth plaque score, probing depth, clinical attachment level, bleeding on probing, recessions, mobility, and migration. For early diagnosis of periodontitis chair side diagnostic tests are available which are used by periodontist. There are many biomarkers for periodontitis which help in early detection like: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations.
牙周炎是一种细菌感染,其发病机制具有复杂的免疫反应。诊断的依据是患者的牙周健康状况、全口出血评分、全口牙菌斑评分、探诊深度、临床附着水平、探诊出血、凹陷、移动和移位。为了早期诊断牙周炎,牙周病医生可以使用椅旁诊断测试。有许多牙周炎的生物标志物有助于早期检测,例如MMP-8(金属蛋白酶-8)、MIP-1α(巨噬细胞炎症蛋白-1α)、IL-1 β(白细胞介素-1β)、IL-6(白细胞介素-6)和 HB(血红蛋白)及其组合。
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引用次数: 0
Salivary biomarkers – Emerging era in periodontics 唾液生物标志物--牙周病学的新时代
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.017
N. Thomas, Kavya S, Thomas George V
Periodontitis is a chronic inflammatory noncommunicable disease that affects all parts of the periodontium and causes irreversible damage. A biological sign of either pathogenic or normal processes is called a biomarker. Finding biomarkers is helpful for tracking the advancement of pathological conditions as well as for disease prevention, diagnosis, and prognosis. Effective treatment depends heavily on early disease identification. The disease process's severity and potential implications are lessened by early detection and treatment. Traditional clinical criteria are frequently inadequate in the field of periodontology to identify sites of active disease, track the effectiveness of therapy, or gauge the degree of vulnerability to future. Medical researchers are committed to identifying molecular illness biomarkers that indicate a concealed deadly threat prior to the disease becoming complicated in order to overcome this obstacle. Saliva is a vital physiological fluid that contains a complex mixture of chemicals. As a diagnostic tool, it is becoming more and more popular.
牙周炎是一种慢性炎症性非传染性疾病,会影响牙周的各个部位,造成不可逆转的损害。致病或正常过程的生物标志称为生物标志物。寻找生物标志物有助于跟踪病理状况的发展,也有助于疾病的预防、诊断和预后。有效的治疗在很大程度上取决于疾病的早期识别。及早发现和治疗可减轻疾病过程的严重程度和潜在影响。在牙周病学领域,传统的临床标准往往不足以确定活动性疾病的部位、跟踪治疗效果或衡量未来的易感程度。为了克服这一障碍,医学研究人员致力于确定分子疾病生物标志物,这些标志物能在疾病变得复杂之前显示出隐藏的致命威胁。唾液是一种重要的生理液体,含有复杂的化学混合物。作为一种诊断工具,它正变得越来越受欢迎。
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引用次数: 0
Management of Miller’s Class-III multiple recession defects in mandibular anterior teeth using vista technique and PRF membrane: A case report 使用 Vista 技术和 PRF 膜治疗下颌前牙 Miller's III 级多发性退缩缺损:病例报告
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.019
Shiny Supriya Lanka, Rajasekar Sundaram, Lakshmi Sree Sankar
Gingival recession, characterized by the displacement of gingival tissue towards the root surface, poses challenges like compromised aesthetics and heightened vulnerability to dental issues such as root caries and sensitivity. Various surgical techniques have been developed to address these concerns, with recent advancements like the Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique showing promise, especially for multiple recession defects in the esthetic zone. VISTA reduces tissue trauma and promotes optimal healing by minimizing micromotion, thus enhancing the overall success of root coverage procedures. Integrating Platelet-rich fibrin (PRF) membranes aids in soft tissue healing and graft integration, offering a cost-effective and immune-friendly option to bolster procedure success.In a 31-year-old female patient with receding gums and mobile teeth, vestibuloplasty was performed after oral prophylaxis and stabilization of mobile teeth to address the inadequate vestibular depth and mucogingival deformity. Post-operative care included antibiotics and pain relief medications. Subsequently, a Miller’s Class-III multiple gingival defect (MRD) was corrected using the VISTA technique combined with Platelet-rich fibrin (PRF) membrane application. PRF was inserted into the tunnel to cover the denuded roots and to improve the gingival phenotype and the surgical site was sutured. One month later, successful healing was evident with increased vestibular depth, demonstrating effective treatment outcomes.
牙龈退缩的特点是牙龈组织向牙根表面移位,它带来的挑战包括影响美观、更容易出现牙根龋和敏感等牙科问题。为了解决这些问题,人们开发了各种手术技术,最近的进展是前庭切口骨膜下隧道入路(VISTA)技术,尤其是针对美观区的多发性退缩缺损,该技术显示了良好的前景。VISTA 减少了微动,从而减少了组织创伤,促进了最佳愈合,提高了牙根覆盖手术的整体成功率。一名牙龈退缩、牙齿活动的 31 岁女性患者在口腔预防和稳定活动牙齿后接受了前庭成形术,以解决前庭深度不足和粘膜龈畸形的问题。术后护理包括抗生素和止痛药物。随后,采用 VISTA 技术结合富血小板纤维蛋白(PRF)膜应用,矫正了米勒氏 III 级多发性牙龈缺损(MRD)。在隧道中植入富血小板纤维蛋白膜以覆盖缺损的牙根,改善牙龈表型,然后缝合手术部位。一个月后,伤口愈合成功,前庭深度增加,显示出有效的治疗效果。
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引用次数: 0
Microbial dynamics: Understanding the triad of periodontal pathogens 微生物动态:了解牙周病原体的三要素
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.016
Burnice Nalina Kumari Chellathurai, Devadharshini Chandrasekar, Uma Subbiah, V. Rajaram, Jaideep Mahendra
Periodontal diseases are complex inflammatory conditions of the oral cavity, affecting a significant portion of the global population. Central to the pathogenesis of these diseases is the intricate interplay between microbial pathogens, host immune response, and environmental factors. Among the diverse array of microorganisms inhabiting the oral microbiome, a triad of pathogens—Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola—commonly referred to as the
牙周病是一种复杂的口腔炎症,影响着全球相当一部分人口。这些疾病发病机制的核心是微生物病原体、宿主免疫反应和环境因素之间错综复杂的相互作用。在栖息于口腔微生物组的各种微生物中,牙龈卟啉单胞菌、连翘坦奈氏菌和牙周特雷波纳菌这三种病原体通常被称为牙周微生物组。
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引用次数: 0
Optimizing peri-implant health: The crucial role of soft tissue condition in bone regenerative procedures 优化种植体周围健康:软组织状况在骨再生手术中的关键作用
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.015
Preeti Kale, Bhargav Kuchu, Jeevan B S, Sunny Mavi, Jamalpur Karthik Raj
Peri-implant health is paramount for the long-term success of dental implants. While bone regeneration techniques have been extensively studied and employed to ensure implant stability, the significance of soft tissue condition in this context is increasingly recognized. This review article explores the intricate interplay between soft tissue dynamics and bone regenerative procedures in the pursuit of optimal peri-implant health. Soft tissue condition around dental implants plays a multifaceted role in supporting long-term stability and functionality. Adequate soft tissue thickness, contour, and attachment are crucial for maintaining a healthy peri-implant environment and preventing complications such as peri-implantitis and mucosal recession. Furthermore, soft tissue quality influences the outcomes of bone regeneration procedures by affecting vascularization, wound healing, and tissue integration. Various strategies have been proposed to enhance soft tissue condition in conjunction with bone regenerative techniques. Through a comprehensive review of existing literature, this article aims to elucidate the pivotal role of soft tissue condition in bone regenerative procedures and its implications for long-term peri-implant health. Insights gained from this review will inform clinicians and researchers in devising effective strategies to enhance soft tissue quality and ensure the success and longevity of dental implant therapy.
种植体周围的健康对牙科种植体的长期成功至关重要。虽然骨再生技术已被广泛研究和使用,以确保种植体的稳定性,但软组织状况在这方面的重要性也日益得到认可。这篇综述文章探讨了在追求最佳种植体周围健康的过程中,软组织动力学和骨再生程序之间错综复杂的相互作用。牙科种植体周围的软组织状况在支持长期稳定性和功能性方面起着多方面的作用。足够的软组织厚度、轮廓和附着力对于维持健康的种植体周围环境以及预防种植体周围炎和粘膜衰退等并发症至关重要。此外,软组织的质量还会影响血管生成、伤口愈合和组织整合,从而影响骨再生手术的效果。人们提出了各种策略来改善软组织状况,并将其与骨再生技术相结合。本文通过对现有文献的全面回顾,旨在阐明软组织条件在骨再生手术中的关键作用及其对长期种植体周围健康的影响。从这篇综述中获得的见解将为临床医生和研究人员提供参考,帮助他们制定有效的策略来提高软组织质量,确保种植牙治疗的成功和长久。
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引用次数: 0
Treatment of periodontal osseous defect with bio-oss xenograft and biodegradable IGF fibers: A case report 用生物粘土异种移植和生物可降解 IGF 纤维治疗牙周骨缺损:病例报告
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.022
Mutthineni Ramesh Babu, Arpita Paul, Puramu Pravalika
Osseous defect caused due to periodontitis needed to be repaired or regenerated to avoid tooth loss. Bio-oss is made up of 10% porcine collagen and can induce osteoblastic differentiation due to its volumetric stability and out standing osteoconductive properties. Application of growth factors in regenerative procedures have helped to maintain the scaffold and induce several cellular processes. The biodegradable fibers incorporated with IGF growth factor has strong effect on PDL fibroblasts, mitogenesis, and protein synthesis which promotes osteogenesis and cementogenesis. A patient having grade II furcation and intrabony defect was treated and evaluated after 12 months with biodegradable fibers infused with insulin like growth factor and bio oss xeno graft irt 36. Treated site responded well to the use of the bovine bone mineral with good tissue response and an improvement and there was an overall mean probing pocket reduction in the deepest site of osseous defects. The clinical parameters assessed are plaque index, bleeding on brobing, pocket probing depth, clinical attachment level, glickman’s furcation index and RVG at baseline, 6 and 12 months post operatively. Both the bone grafts resulted in better regeneration when compared to base line and 12 months.Bio oss (bovine bone mineral) and biodegradable fibres infused with insulin like growth factor materials are of considerable promise for regeneration with better clinical and radiographic outcomes.
牙周炎造成的骨缺损需要修复或再生,以避免牙齿脱落。生物黏土由 10%的猪胶原蛋白组成,由于其体积稳定性和突出的骨诱导特性,可以诱导成骨细胞分化。在再生过程中应用生长因子有助于维持支架并诱导多个细胞过程。含有 IGF 生长因子的生物可降解纤维对 PDL 成纤维细胞、有丝分裂和蛋白质合成有很强的作用,可促进成骨和骨水泥形成。一名患有 II 级沟槽和骨内缺损的患者接受了注入胰岛素样生长因子的生物可降解纤维和 bio oss xeno graft irt 36 的治疗,并在 12 个月后进行了评估。治疗部位对牛骨矿物质的使用反应良好,组织反应良好,骨缺损最深部位的探查袋总体平均缩小。评估的临床参数包括基线、术后 6 个月和 12 个月的菌斑指数、龈沟出血、探诊袋深度、临床附着水平、格立克曼毛囊指数和 RVG。生物骨(牛骨矿物质)和注入胰岛素样生长因子材料的生物可降解纤维在再生方面具有相当大的前景,可获得更好的临床和影像学效果。
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引用次数: 0
Periodontal management during orthodontic-surgical treatment of maxillary impacted incisors: Acase report 上颌影响切牙正畸手术治疗期间的牙周管理:病例报告
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.020
Khamlich Kenza, Ouled Bouallala Meriem, Chemlali Siham, Alami Sanaa, Kissa Jamila
The treatment of impacted teeth is a multidisciplinary process requiring close collaboration between periodontics and orthodontics. Impaction can have several causes, including physical obstructions in the eruption pathway, arch length discrepancies, or dental deformity. The management of these cases lies in the diagnosis established after an appropriate clinical and radiological examination. The age, position, etiology, and amount of space in the dental arch of an unerupted tooth determine how it should be treated. In several cases, orthodontic creating space, removing physical obstructions, and exposing the patient surgically with or without traction are general guidelines for treatment. In addition, ensuring adequate access to the tooth and the possibility of attaching an orthodontic anchor, the periodontal plastic surgery procedures associated with surgical clearance must preserve the integrity of the periodontium of the impacted tooth, as well as that of adjacent teeth, and above all promote the long-term maintenance of their periodontal health.
阻生牙的治疗是一个多学科的过程,需要牙周病学和正畸学的密切合作。阻生牙的形成有多种原因,包括萌出路径中的物理障碍、牙弓长度差异或牙齿畸形。对这些病例的处理在于经过适当的临床和放射检查后确定诊断。未萌出牙齿的年龄、位置、病因和牙弓空间大小决定了治疗方法。在一些病例中,正畸创造空间、去除物理障碍物以及通过或不通过牵引手术暴露患者是治疗的一般准则。除了确保有足够的机会接触到牙齿并有可能安装正畸锚之外,与手术清除相关的牙周整形手术还必须保护受影响牙齿的牙周以及邻近牙齿的完整性,最重要的是促进其牙周健康的长期维护。
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引用次数: 0
Challenges and solutions in plasma cell gingivitis: A clinical case analysis 浆细胞牙龈炎的挑战与解决方案:临床病例分析
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.021
Abdurasheed E. M Edakkod Mathamkuth, Raseena Beevi N, Rafeek Ra, Roshni Ramesh, Sharon Philip
Plasma cell gingivitis (PCG) is an uncommon benign gingival condition characterized by sharply defined erythematous and oedematous gingival lesions, often extending to the mucogingival junction. This hypersensitivity reaction presents as diffuse, papillary gingival inflammation, prone to bleeding upon minimal trauma. Histologically, PCG manifests as a dense infiltration of normal plasma cells within collagenous stroma, typically localized to the free and attached gingiva. The primary management approach involves identification and avoidance of the allergen source, alongside nonsurgical periodontal therapy. We report a 26-years-old female patient diagnosed clinically as plasma cell gingivitis and confirmed histologically. Surgical treatment along with pharmacological interventions resulted in complete resolution of symptoms. This case underscores the importance of comprehensive evaluation and tailored treatment approaches in managing plasma cell gingivitis.
浆细胞性牙龈炎(PCG)是一种不常见的良性牙龈疾病,其特征是牙龈出现界限清晰的红斑和水肿,通常会延伸到粘龈交界处。这种超敏反应表现为弥漫性乳头状牙龈炎症,在受到轻微创伤时容易出血。组织学上,PCG 表现为胶原基质中正常浆细胞的密集浸润,通常发生在游离龈和附着龈。主要的治疗方法包括识别和避免过敏源,同时进行非手术牙周治疗。我们报告了一名 26 岁的女性患者,临床诊断为浆细胞性牙龈炎,并经组织学证实。通过手术治疗和药物干预,患者的症状得到完全缓解。本病例强调了全面评估和针对性治疗方法在治疗浆细胞性牙龈炎中的重要性。
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引用次数: 0
From surface to success: How implant surfaces shape osseointegration 从表面到成功:种植体表面如何形成骨结合
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.013
Varun Kumar, Jyotna Seth, Manas Aeran, Ashish Sani
The field of dental implantology has significantly advanced to address the multifaceted impacts of tooth loss, encompassing physical, functional, emotional, psychological, and social dimensions. Dental implants serve as reliable solutions, ensuring stability, minimal bone loss, and absence of pain or infection. Central to their success is the surface modification of implants, which profoundly influences osseointegration—the process crucial for establishing a functional bond between bone and implant. This review explores various physical modifications of dental implant surfaces, focusing on macro, micro, and nano-level alterations. Macro-level modifications optimize implant geometry and thread design to enhance initial stability and long-term fixation. Micro-level modifications, including grit blasting and acid etching, increase surface roughness to facilitate mechanical interlocking and cell adhesion. Nano-level modifications, such as hydrophilic coatings and bioceramic enhancements, enhance surface energy and promote osteoblastic differentiation, thereby accelerating osseointegration. These surface modifications represent a critical frontier in implant dentistry, promising improved clinical outcomes and patient satisfaction through enhanced integration and reduced healing times.
种植牙技术在解决牙齿缺失带来的多方面影响方面取得了长足的进步,包括生理、功能、情感、心理和社会等方面。种植牙是一种可靠的解决方案,可确保稳定性、最小的骨质流失以及无痛或无感染。成功的关键在于种植体的表面改良,这对骨结合有深远的影响--骨与种植体之间建立功能性结合的关键过程。本综述探讨了牙科种植体表面的各种物理改良,重点关注宏观、微观和纳米级改良。宏观改良可优化种植体的几何形状和螺纹设计,以增强初期稳定性和长期固定性。微米级改良,包括喷砂和酸蚀,可增加表面粗糙度,促进机械联锁和细胞粘附。纳米级改良,如亲水涂层和生物陶瓷增强,可提高表面能量并促进成骨细胞分化,从而加速骨结合。这些表面改性技术代表了种植牙领域的一个重要前沿,有望通过提高整合度和缩短愈合时间来改善临床效果和患者满意度。
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引用次数: 0
Evaluation of patient perception and intraoperative bleeding in labial frenectomy: A comparision of diode laser and conventional scalpel techniques 评估唇缘切除术中患者的感觉和术中出血量:二极管激光与传统手术刀技术的比较
Pub Date : 2024-07-15 DOI: 10.18231/j.ijpi.2024.018
Mutthineni Ramesh Babu, Arpita Paul, Amula Vinay Sagar, Mandem Harshini Sai
: High frenal attachments are abnormalities corrected by surgical procedure called frenectomies. The scalpel technique is associated with pain, bleeding and postoperative discomfort. To overcome these shortcomings, in the recent times, diode lasers are gaining popularity due to less bleeding, pain during the procedure, healing outcome, and need for analgesics: To compare the bleeding during the procedure and postoperative pain in patients requiring labial frenectomy using conventional scalpel and diode laser techniques. Twenty patients with high labial frenum attachment requiring frenectomy were included in this study. Patients were randomly divided into Group A: scalpel group and Group B: diode laser group. Pain assessment using VAS, severity of intraoperative bleeding and number of analgesics used were recorded: The analysis showed that VAS score for pain was significantly lower in the laser group as compared to the scalpel group Bleeding was mild in laser group, where as in scalpel group showed moderate or severe bleeding scores Post operative use of analgesics was more in scalpel group than laser group Laser was found to be an effective alternate to scalpel in performing frenectomy procedures, more importantly it showed less bleeding, less pain perception and more patient acceptance during the procedure.
:肾前区高位附着是一种异常现象,可通过外科手术矫正,这种手术被称为肾前区切除术(frenectomies)。手术刀技术会带来疼痛、出血和术后不适。为了克服这些缺点,近来,二极管激光因出血少、术中疼痛轻、愈合效果好、无需镇痛药而越来越受欢迎:比较使用传统手术刀和二极管激光技术进行唇系带切除术的患者术中出血量和术后疼痛情况。本研究纳入了 20 名唇系膜高位附着、需要进行唇系膜切除术的患者。患者被随机分为 A 组:手术刀组和 B 组:二极管激光组。分析结果表明,与手术刀组相比,激光组患者的疼痛VAS评分明显较低。 激光组患者的出血量较轻,而手术刀组患者的出血量为中度或重度。术后,手术刀组患者的镇痛剂使用量高于激光组患者。
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引用次数: 0
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IP international journal of periodontology and implantology
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