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Underestimated risk: Tuberculosis transmission from pathogen-negative patients in schools 被低估的风险:学校中病原体阴性患者的结核病传播
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-19 DOI: 10.1016/j.puhe.2025.106096
Yaqian Su , Bijuan Zhong , Ruiming Chen , Zhuanghao Chen , Jianxiong Lin , Hui Fu , Zicheng Cao , Qiaocheng Chang , Liping Li , Suyang Liu

Objectives

This study evaluates TB infection risk among close contacts of both pathogen-positive and pathogen-negative TB patients, emphasizing the need for broader prevention strategies.

Study design

This study employed a cross-sectional design.

Methods

This study screened close contacts of TB patients in schools across Shantou, China from 2019 to 2023. A strong positive reaction in the purified protein derivative (PPD) test served as the key indicator of TB infection among contacts. The infection proportion for different close contact groups was calculated. Additionally, logistic regression analysis was utilized to identify factors influencing TB infection among close contacts.

Results

Among 10,586 contacts, the overall infection prevalence proportion was 17.8 %. Close contacts of pathogen-negative patients had a higher infection prevalence proportion (18.1 %) than those of pathogen-positive patients (17.1 %) (adjusted OR 1.25; 95 % CI 1.11–1.40). Key risk factors included gender, age, relationship with the index case, school type, and pathogen type. Females and individuals aged 15+ were more susceptible.

Conclusions

Current strategies mainly focus on contacts of pathogen-positive patients, neglecting pathogen-negative contacts, which may increase transmission risk. Strengthening the identification and management of all potential transmission sources in schools is crucial, with enhanced monitoring and stricter preventive measures for contacts of pathogen-negative patients.
目的本研究评估病原体阳性和病原体阴性结核患者密切接触者的结核感染风险,强调需要更广泛的预防策略。研究设计本研究采用横断面设计。方法对2019 - 2023年汕头市学校结核病患者密切接触者进行筛查。纯化蛋白衍生物(PPD)试验阳性反应强烈,可作为接触者结核感染的关键指标。计算不同密切接触人群的感染比例。此外,采用logistic回归分析确定密切接触者中结核病感染的影响因素。结果10586名接触者中,总感染率为17.8%。病原体阴性患者密切接触者感染流行率(18.1%)高于病原体阳性患者(17.1%)(调整OR为1.25;95% CI为1.11 ~ 1.40)。主要危险因素包括性别、年龄、与指示病例的关系、学校类型和病原体类型。女性和15岁以上的人更容易感染。结论目前的防控措施主要关注病原体阳性患者的接触者,忽视了病原体阴性患者的接触者,可能会增加传播风险。加强学校中所有潜在传播源的识别和管理至关重要,要加强对病原体阴性患者接触者的监测和更严格的预防措施。
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引用次数: 0
Public reporting guidelines for outbreak data: Enabling accountability for effective outbreak response by developing standards for transparency and uniformity 疫情数据公开报告准则:通过制定透明度和统一性标准,实现有效疫情应对的问责制
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-19 DOI: 10.1016/j.puhe.2025.106102
V. Grégoire , A.W. Zhu , C.M. Brown , J.S. Brownstein , D. Cardo , F. Cumming , R. Danila , C.A. Donnelly , J.S. Duchin , M.A. Fill , K. Fullerton , S. Funk , D. George , S. Hopkins , M.U.G. Kraemer , M. Layton , J. Lessler , R. Lynfield , J.M. McCaw , T.D. McPherson , C.M. Rivers

Objectives

There are few standards for what information about an infectious disease outbreak should be reported to the public and when. To address this problem, we undertook a consensus process to develop recommendations for what epidemiological information public health authorities should report to the public during an outbreak.

Study design

We conducted a Delphi study following the steps outlined in the ACcurate COnsensus Reporting Document (ACCORD) for health-related activities or research.

Methods

We assembled a steering committee of nine experts representing federal and state public health, academia, and international partners to develop a candidate list of reporting items. We then invited 45 experts, 35 of whom agreed to participate in a Delphi panel. Of those, 25 participated in voting in the first round, 25 in the second round, and 25 in the third round, demonstrating consistent engagement in the consensus-building process. The final stage of the Delphi process consisted of a hybrid consensus meeting to finalize the voting items.

Results

The Delphi process yielded nine core reporting items representing a minimum standard for public outbreak reporting: numbers of new confirmed cases, new hospital admissions, new deaths, cumulative confirmed cases, cumulative hospital admissions, and cumulative deaths, each reported weekly and at Administrative Level 1 (typically state or province), and stratified by sex, age group, and race/ethnicity.

Conclusions

This minimum reporting standard creates a strong framework for uniform sharing of outbreak information and promotes consistency of data between jurisdictions, enabling effective response by promoting access to information about an unfolding epidemic.
目的关于传染病暴发应向公众报告哪些信息以及何时报告,目前没有什么标准。为解决这一问题,我们开展了协商一致进程,就公共卫生当局在疫情暴发期间应向公众报告哪些流行病学信息提出建议。研究设计我们按照准确共识报告文件(ACCORD)中关于健康相关活动或研究的步骤进行了德尔菲研究。方法:我们组建了一个由代表联邦和州公共卫生、学术界和国际合作伙伴的9名专家组成的指导委员会,以制定一份报告项目候选清单。然后我们邀请了45位专家,其中35位同意参加德尔菲小组。其中,25个国家参加了第一轮投票,25个国家参加了第二轮投票,25个国家参加了第三轮投票,表明一贯参与建立共识的进程。德尔菲过程的最后阶段包括一次混合共识会议,以确定投票项目。结果德尔菲过程产生了代表公共疫情报告最低标准的9个核心报告项目:新确诊病例数、新住院病例数、新死亡病例数、累计确诊病例数、累计住院病例数和累计死亡病例数,每个项目每周报告一次,并在一级行政级别(通常是州或省)报告,并按性别、年龄组和种族/民族分层。这一最低报告标准为统一共享疫情信息创造了强有力的框架,并促进了司法管辖区之间数据的一致性,通过促进获取有关正在发生的流行病的信息,实现了有效的应对。
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引用次数: 0
Loneliness among older adults with multiple chronic conditions: Exploring disparities for Hispanic adults in the 2023 Behavioral Risk Factor Surveillance System 患有多种慢性疾病的老年人的孤独感:探索2023年行为风险因素监测系统中西班牙裔成年人的差异
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-19 DOI: 10.1016/j.puhe.2025.106100
Derek S. Falk , Alfonso J. Rojas-Álvarez , Deborah M. Parra-Medina , Christian E. Vazquez

Objectives

Loneliness among older adults is a public health concern negatively impacting those with multimorbidity. As the population continues to age in the United States and the proportion of Hispanics grows, understanding the relationship between loneliness and multimorbidity for Hispanic older adults warrants further examination. Previous studies have explored loneliness and multimorbidity, but examine the impact on Hispanic older adults. To achieve this aim, we assessed loneliness and disparities in the dose-response relationship of multimorbidity in adults aged 65+.

Study design

Cross-sectional observational study using data from the 2023 Behavioral Risk Factor Surveillance System (BRFSS).

Methods

Weighted analyses represented U.S. adults aged 65+. Descriptive statistics and chi-square tests compared prevalence by ethnicity. Multivariable logistic regression models identified factors associated with loneliness in the overall sample and Hispanic subgroup. Predicted probabilities were plotted to highlight differences by race, ethnicity, and sex.

Results

Among U.S. adults aged 65+, 35.0 % reported feeling lonely. Hispanic older adults reported a higher prevalence of loneliness than non-Hispanic older adults (40.2 % vs 34.5 %) and were more likely to receive inadequate social support (10.7 % vs 6.3 %). Hispanic females showed the strongest dose-response effect, with loneliness increasing from 41 % (no conditions) to 57 % (3+ conditions).

Conclusions

Being Hispanic, regardless of sex, increased likelihood of loneliness and inadequate social support; however, Hispanic older females face the highest levels of loneliness when managing multimorbidity with inadequate social support compared to Hispanic males and individuals of other races/ethnicities. Further research is needed to address these disparities for Hispanics and women in particular.
目的:老年人孤独感是一个公共卫生问题,对多病人群有负面影响。随着美国人口的持续老龄化和西班牙裔人口比例的增长,了解西班牙裔老年人孤独感和多重疾病之间的关系值得进一步研究。之前的研究探讨了孤独和多重疾病,但研究了对西班牙裔老年人的影响。为了实现这一目标,我们评估了65岁以上成年人多病的孤独感和剂量-反应关系的差异。研究设计采用2023年行为风险因素监测系统(BRFSS)数据的横断面观察性研究。方法加权分析对象为65岁以上的美国成年人。描述性统计和卡方检验比较了不同种族的患病率。多变量logistic回归模型确定了总体样本和西班牙裔亚组中与孤独感相关的因素。预测的概率被绘制出来,以突出种族、民族和性别的差异。结果在65岁以上的美国成年人中,35.0%的人表示感到孤独。西班牙裔老年人报告的孤独感患病率高于非西班牙裔老年人(40.2%比34.5%),更有可能得不到足够的社会支持(10.7%比6.3%)。西班牙裔女性表现出最强的剂量反应效应,孤独感从41%(无条件)增加到57%(3+条件)。结论:西班牙裔,无论性别,孤独感和社会支持不足的可能性增加;然而,与西班牙裔男性和其他种族/民族的个体相比,西班牙裔老年女性在缺乏社会支持的情况下管理多重疾病时面临的孤独感最高。需要进一步的研究来解决这些差距,特别是西班牙裔和妇女。
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引用次数: 0
Women's initial preferences for self-sampling tests at home for cervical cancer screening in the UK: A mixed-methods analysis of demographic and behavioural factors 在英国,妇女对在家进行宫颈癌筛查的自我抽样测试的最初偏好:人口统计学和行为因素的混合方法分析。
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-18 DOI: 10.1016/j.puhe.2025.106109
Y. Eraso , D. Stefler , V. Whitelock , E. Clarke , D. Williams

Objectives

To identify the demographic and behavioural factors associated with cervical screening preferences if a choice of test, health professional-collected samples or self-sampling at home, is implemented in the UK; and the behavioural barriers to self-sampling at home.

Study design

A mixed-methods study of secondary data.

Methods

We used data from the Cancer Research UK CAM + survey (February 2023) and performed a quantitative regression analysis to examine the associations between demographics, behavioural factors, screening behaviours, and screening preferences of the UK population aged 25–64. Unadjusted and multivariable adjusted logistic regression models were used. Qualitative content analysis was used for free text comments on behavioural barriers to self-sampling and mapped onto the Theoretical Domains Framework.

Results

Analytical sample (n = 906). Test preference: Self-sampling (45.4 %); health professional-collected samples (41.1 %); and no test preference (13.6 %). Preference for self-sampling was significantly associated with older groups and psychosocial barriers (motivation and physical opportunity) regarding health professional-collected samples. Individuals with no test preference were the youngest and older groups, from low social grade and living with a partner. Behavioural barriers included test reliability and ability to do the test (motivation) and information needs (capability).

Conclusions

Home seems a suitable setting for self-sampling, and it could alleviate many barriers faced to health professional-collected samples. Yet introducing test options did not allow all individuals a compelling basis for preference. Specific behaviour change techniques for identified barriers are proposed for this group. Ultimately, if choice is offered, future screening guidelines should consider how to address individuals with no test preference.
目标:如果在联合王国实施一种检测选择,即由卫生专业人员收集样本或在家中自行抽样,确定与子宫颈筛查偏好相关的人口统计学和行为因素;以及在家进行自我抽样的行为障碍。研究设计:二级数据的混合方法研究。方法:我们使用来自英国癌症研究中心(Cancer Research UK) CAM +调查(2023年2月)的数据,并进行定量回归分析,以检验英国25-64岁人群的人口统计学、行为因素、筛查行为和筛查偏好之间的关系。采用未调整和多变量调整logistic回归模型。定性内容分析用于自抽样行为障碍的自由文本评论,并映射到理论领域框架。结果:分析样品(n = 906)。测试偏好:自抽样(45.4%);卫生专业人员采集的样本(41.1%);无考试偏好(13.6%)。对自我抽样的偏好与老年群体和对卫生专业人员收集的样本的心理社会障碍(动机和身体机会)显著相关。没有测试偏好的个体是最年轻和年龄较大的群体,来自社会地位较低和与伴侣生活在一起。行为障碍包括测试可靠性和测试能力(动机)和信息需求(能力)。结论:家庭是一种适宜的自采样环境,可以缓解卫生专业人员采集样本面临的诸多障碍。然而,引入测试选项并不能让所有人都有一个令人信服的偏好基础。针对这一群体提出了针对已识别障碍的具体行为改变技术。最终,如果有选择,未来的筛查指南应该考虑如何解决没有测试偏好的个体。
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引用次数: 0
Prevalence of infertility among nationally representative women in Japan: A cross-sectional survey using a two-stage stratified systematic sampling design 日本全国代表性女性不孕症患病率:采用两阶段分层系统抽样设计的横断面调查
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-18 DOI: 10.1016/j.puhe.2025.106092
Eri Maeda , Shoko Konishi , Satoshi Sunohara , Seung Chik Jwa , Isao Yokota , Jacky Boivin , Kyoko Nomura , Akiko Tamakoshi

Objectives

According to the 2021 Japanese National Fertility Survey, more than one-third of couples expressed concerns about infertility. However, no study in Japan has estimated the prevalence of infertility according to the World Health Organization definition (12 months of infertility). This study aimed to estimate the prevalence of infertility based on this definition.

Study design

A cross-sectional study design.

Methods

The survey was conducted in 2024 using a two-stage stratified systematic sampling design (response rate: 40.0 %). Among 1200 women aged 25–49 years (total participants), 853 were married or cohabiting with a male partner (cohabiting participants). There were 35 women aged 25–44 years, at risk of pregnancy, and actively trying to conceive (current duration participants). Lifetime and period prevalence were estimated using direct (self-reported) and current duration methods.

Results

Among cohabiting participants, the lifetime and period prevalence of infertility were 37.8 % (95 % confidence interval [CI]: 35.4 %–40.4 %) and 6.5 % (95 % CI: 5.1 %–8.4 %), respectively. Period prevalence among current duration participants was 23.1 % (95 % CI: 12.1 %–43.9 %). Help-seeking behaviour was reported by 51.1 % of those with lifetime infertility. Older age groups exhibited higher lifetime prevalence and lower period prevalence of infertility. Higher educational attainment was associated with lower lifetime and period prevalence of infertility and a higher help-seeking rate.

Conclusion

While period prevalence estimated using direct and current duration methods was consistent with international findings, lifetime prevalence estimated using direct method was higher, possibly due to older age distribution, delayed parenthood, shorter or ambiguous reproductive intention, and infrequent sexual activity.
根据2021年日本全国生育调查,超过三分之一的夫妇表达了对不孕症的担忧。然而,日本没有研究根据世界卫生组织的定义(12个月的不孕症)估计不孕症的发病率。本研究旨在根据这一定义估计不孕症的患病率。研究设计横断面研究设计。方法调查于2024年进行,采用两阶段分层系统抽样设计,回复率为40.0%。在1200名25-49岁的女性(总参与者)中,853名已婚或与男性伴侣同居(同居参与者)。有35名年龄在25-44岁之间,有怀孕风险并正在积极尝试怀孕的女性(当前参与者)。使用直接(自我报告)和当前持续时间方法估计终生和期间患病率。结果在同居参与者中,终生不孕症患病率为37.8%(95%可信区间[CI]: 35.4% - 40.4%),期间不孕症患病率为6.5%(95%可信区间[CI]: 5.1% - 8.4%)。当前病程参与者的期患病率为23.1% (95% CI: 12.1% - 43.9%)。有51.1%的终生不孕症患者有求助行为。年龄较大的人群表现出较高的终生患病率和较低的时期患病率。较高的教育程度与较低的终生和期间不孕症患病率以及较高的求助率相关。结论使用直接法和当前持续时间法估计的期患病率与国际研究结果一致,但使用直接法估计的终生患病率较高,可能是由于年龄分布较大、生育延迟、生育意愿较短或不明确以及性行为不频繁所致。
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引用次数: 0
Understanding hazardous drinking: The role of anxiety sensitivity and mediating drinking motives 了解危险饮酒:焦虑敏感性和饮酒动机中介的作用
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-18 DOI: 10.1016/j.puhe.2025.106104
Maragda Puigcerver , Lucía Hipólito , Miguel-Ángel Serrano

Objectives

Anxiety sensitivity (AS)—the tendency to fear anxiety-related sensations—has been consistently associated with risky drinking, yet the motivational mechanisms underlying this link remain unclear. This study examined whether specific drinking motives (DMs) mediate the association between AS and hazardous drinking, and explored the moderating effects of age and gender.

Study design

A cross-sectional, survey-based design was used.

Methods

Data were collected through an anonymous online questionnaire completed by 372 adults (69 % women; mean age = 25.3 years), including the Alcohol Use Disorders Identification Test (AUDIT), the Anxiety Sensitivity Index-3 (ASI-3), and four single-item DMs assessing social, avoidance, pleasure, and need-related motives. Analyses were restricted to participants with AUDIT >0. Correlation and regression analyses examined associations among AS, age, gender, and alcohol use. Structural equation modelling (SEM) tested AS as a latent construct (ASI-3 subscales as indicators) and the four DMs as parallel mediators of the AS–AUDIT relationship.

Results

Higher AS was associated with greater alcohol use, even after controlling for age and gender. SEM confirmed that AS formed a coherent latent factor and that motives operated in parallel. AS was positively linked to avoidance motives; however, this pathway did not mediate the AS–alcohol link. Only the social motive uniquely predicted higher AUDIT scores, while younger age—but not gender—was consistently associated with greater consumption.

Conclusions

Hazardous drinking was mainly explained by social motives and younger age. AS contributed indirectly through its influence on drinking motives rather than a direct effect.
焦虑敏感性(AS)——害怕焦虑相关感觉的倾向——一直与危险饮酒有关,但这种联系背后的动机机制尚不清楚。本研究考察了特定饮酒动机(DMs)是否在AS与危险饮酒之间起中介作用,并探讨了年龄和性别的调节作用。研究设计采用横断面、基于调查的设计。方法372名成年人(69%为女性,平均年龄25.3岁)通过匿名在线问卷收集数据,包括酒精使用障碍识别测试(AUDIT)、焦虑敏感性指数-3 (ASI-3)和评估社交、回避、愉悦和需求相关动机的四项单项dsm。分析仅限于AUDIT >;0的参与者。相关和回归分析检验了AS、年龄、性别和酒精使用之间的关系。结构方程模型(SEM)测试了AS作为潜在结构(ASI-3子量表作为指标)和四个dm作为AS审计关系的平行中介。结果即使在控制了年龄和性别之后,高AS与更多的酒精使用有关。扫描电镜证实,AS形成了一个连贯的潜在因素,动机是并行的。AS与回避动机呈正相关;然而,这一途径并没有介导as -醇的关联。只有社会动机能唯一地预测更高的审计分数,而年轻的年龄(而不是性别)始终与更高的消费相关。结论不良饮酒的主要原因是社会动机和低龄化。AS对饮酒动机的影响是间接的,而不是直接的。
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引用次数: 0
Comparing perceived and objective measures of neighbourhood built environments among youth and adults in Canada 比较加拿大青少年和成年人对社区建筑环境的感知和客观测量
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-18 DOI: 10.1016/j.puhe.2025.106110
Stephanie A. Prince , Yina Shan , Gregory P. Butler , Justin J. Lang , Gavin R. McCormack , Rachel C. Colley

Objectives

To compare perceived and objective measures of the neighbourhood built environment among a representative sample of youth and adults in Canada.

Study design

Cross-sectional study.

Methods

Two cycles (N = 7948) of the Canadian Health Measures Survey (2016–19) were linked to objectively-measured built environment data. Objective measures included walkability, cycling paths, recreation facilities, trails, and major roadways. Perceived built environment features were used to derive a composite measure of walkability. Perceived and objective measures were compared using age group- (12–17, 18–64, 65–79 years) and sex-stratified chi-square tests, Pearson correlations, and independent t-tests.

Results

Although objective measures did not differ by age, youth and working-aged adults generally perceived more neighbourhood amenities than older adults. Adults were more likely than youth to report poorly maintained sidewalks and traffic as barriers to walking and cycling. No sex differences were observed. Across all age groups, the perceived presence of dense housing, shops, transit stops, sidewalks, cycling infrastructure, and low-cost recreation facilities increased with objectively-measured neighbourhood walkability. Perceived and objectively-measured walkability were moderately correlated; features such as transit, sidewalks, recreation facilities, and cycle paths were more common in neighbourhoods where residents reported perceiving them.

Conclusions

Age differences in perceived environmental supports and barriers highlight the need to address age-related disparities to improve walkability. Future research should consider the relationship between perceived and objective built environment features and their impact on physical activity.
目的比较加拿大青年和成年人的代表性样本对社区建筑环境的感知和客观测量。研究设计横断面研究。方法将加拿大健康措施调查(2016 - 2019)的两个周期(N = 7948)与客观测量的建筑环境数据相关联。客观指标包括可步行性、自行车道、娱乐设施、步道和主要道路。可感知的建筑环境特征被用来得出可步行性的综合衡量标准。采用年龄组(12-17岁、18-64岁、65-79岁)、性别分层卡方检验、Pearson相关检验和独立t检验比较感知测量和客观测量。结果:虽然客观测量没有因年龄而异,但年轻人和工作年龄的成年人普遍比老年人感知到更多的社区设施。成年人比年轻人更有可能报告说,人行道和交通状况不佳是步行和骑自行车的障碍。没有观察到性别差异。在所有年龄组中,密集的住房、商店、公交站点、人行道、自行车基础设施和低成本娱乐设施的存在随着客观测量的社区步行性而增加。感知和客观测量的步行能力呈中度相关;交通、人行道、娱乐设施和自行车道等设施在居民报告看到的社区中更为常见。结论感知环境支持和障碍的差异突出了解决与年龄相关的差异以改善步行性的必要性。未来的研究应考虑感知和客观建筑环境特征之间的关系及其对身体活动的影响。
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引用次数: 0
Economic benefits of mental well-being over time: Results from the Netherlands mental health survey and incidence study-2 长期心理健康的经济效益:来自荷兰心理健康调查和发病率研究的结果2。
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-17 DOI: 10.1016/j.puhe.2025.106095
Ben Wijnen , Margreet Ten Have , Linda Bolier , Frederick Thielen , Marlous Tuithof , Annemarie I. Luik , Filip Smit , Laura Shields-Zeeman

Objectives

Understanding economic benefits associated with improved mental well-being in the general population is important for informing population-level strategies. We aimed to estimate the economic impact associated with changes in mental well-being in the Dutch adult population.

Study design

This study was based on a longitudinal cohort (the Netherlands Mental Health Survey and Incidence Study-2)

Methods

5303 adults aged 18–64 years. Were included. Three measurements, each separated by a time interval of three years, were used to evaluate how a change in well-being predicts a change in costs. Well-being was measured using the Mental Health Continuum-Short Form. Societal costs encompassed three cost categories: 1) healthcare costs; 2) productivity losses; and 3) patient and family costs. Main analysis was based on a model where a change in costs Y(t2-t1) was regressed on a synchronically occurring change in well-being X(t2-t1). Additionally, this model was compared with a diachronic model where a subsequent change in costs was regressed on a preceding change in well-being, i.e. Y(t3-t2) on X(t2-t1).

Results

Each %-point increase in mental well-being reduced societal costs by –€50.74 (95 %CI: €78.72; –€22.76) per person, which was statistically significant (SE = 14.27, t = −3.56, p < 0.001). The majority of these savings (89 %) were attributable to increased productivity. In the diachronic model, no significant difference between wellbeing and subsequent costs was found.

Conclusion

This study demonstrated that improvements in mental well-being are potentially associated with simultaneously occurring cost reductions, primarily through increased productivity. Hence, there may be potential for mental well-being interventions to reduce societal costs and enhance productivity at a population level.
目的:了解与改善一般人群心理健康相关的经济效益,对于告知人群层面的策略是重要的。我们的目的是估计与荷兰成年人心理健康变化相关的经济影响。研究设计:本研究基于纵向队列(荷兰心理健康调查和发病率研究-2)。方法:5303名18-64岁的成年人。被包括在内。三个测量,每隔三年的时间间隔,被用来评估福祉的变化如何预测成本的变化。幸福感是用心理健康连续简表来衡量的。社会成本包括三类成本:1)医疗保健费用;2)生产力损失;3)病人和家属的费用。主要分析是基于一个模型,其中成本Y(t2-t1)的变化回归到同步发生的福祉X(t2-t1)的变化。此外,还将该模型与历时模型进行了比较,历时模型中,成本的后续变化回归到之前的福利变化上,即Y(t3-t2)回归到X(t2-t1)。结果:心理健康水平每提高%,人均社会成本降低- 50.74欧元(95% CI: 78.72欧元;- 22.76欧元),这在统计学上具有显著意义(SE = 14.27, t = -3.56, p)。结论:本研究表明,心理健康水平的提高与同时发生的成本降低有潜在关联,主要是通过提高生产力实现的。因此,心理健康干预可能会降低社会成本,提高人口水平的生产力。
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引用次数: 0
Healthy lifestyle mitigates the impact of low-level air pollution on adverse pregnancy outcomes: Evidence from a population-based study 健康的生活方式可减轻低水平空气污染对不良妊娠结局的影响:一项基于人群的研究证据
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-17 DOI: 10.1016/j.puhe.2025.106101
Chuan Li , Rong Song , Xin Yu , Yanhong Fang , Jiayuan Yang , Zhiyuan Tang , Shaoqi Wang , Xunrong Cheng , Jian Song , Weizhuo Yi , Rubing Pan , Hong Su

Objectives

This study aimed to investigate the association between low-level air pollution and adverse pregnancy outcomes, assess the potential mediating role of healthy lifestyle, and identify key modifiable behaviors.

Study design

Case-control study.

Methods

This study included a total of 231,331 female participants from the UK Biobank. A healthy lifestyle score was established based on non-smoking, moderate drinking, healthy diet, regular physical activity, and ideal BMI. Multivariable logistic regression model was used to explore the associations between low-level air pollution, healthy lifestyle and adverse pregnancy outcomes. The eXtreme Gradient Boosting (XGBoost) and SHapley Additive exPlanations (SHAP) were employed to elucidate the relative importance of these modifiable behaviors.

Results

Each 1 μg/m3 increase in PM2.5, PM10, NO2, and NOx was associated with an increased risk of low offspring birthweight. The odds ratios (95 % CI) were 1.046 (1.025–1.068) for PM2.5, 1.015 (1.004–1.027) for PM10, 1.007 (1.004–1.009) for NO2, 1.003 (1.002–1.005) for NOx. No significant associations were found between low-level air pollution and other adverse pregnancy outcomes. Participants with unfavorable lifestyle and higher low-level air pollution had the highest risk of low offspring birthweight. In the modeling study, a healthy diet, and ideal BMI were identified as main modifiable behaviors.

Conclusions

Low-level air pollution was still associated with reduced offspring birth weight. Adopting a healthy lifestyle, especially healthy diet, and ideal BMI, could help mitigate the risks of air pollution. These findings provide evidence to support integrated interventions that combine environmental regulation with lifestyle modification programs to reduce adverse pregnancy outcomes effectively.
目的:探讨低水平空气污染与不良妊娠结局的关系,评估健康生活方式的潜在中介作用,并确定关键的可改变行为。研究设计:病例对照研究。方法:本研究包括来自英国生物银行的231,331名女性参与者。健康生活方式评分建立在不吸烟、适度饮酒、健康饮食、定期体育锻炼和理想BMI的基础上。采用多变量logistic回归模型探讨低水平空气污染、健康生活方式与不良妊娠结局之间的关系。采用极限梯度增强(XGBoost)和SHapley加性解释(SHAP)来阐明这些可修改行为的相对重要性。结果:PM2.5、PM10、NO2和NOx浓度每增加1 μg/m3,子代低出生体重风险增加。PM2.5的比值比为1.046 (1.025-1.068),PM10的比值比为1.015 (1.004-1.027),NO2的比值比为1.007 (1.004-1.009),NOx的比值比为1.003(1.002-1.005)。没有发现低水平空气污染与其他不良妊娠结局之间存在显著关联。不良生活方式和低水平空气污染的参与者后代出生体重低的风险最高。在建模研究中,健康的饮食和理想的BMI被确定为主要的可改变的行为。结论:低水平空气污染仍与后代出生体重降低有关。采用健康的生活方式,尤其是健康的饮食和理想的身体质量指数,可以帮助减轻空气污染的风险。这些发现为支持将环境监管与生活方式改变计划相结合的综合干预措施提供了证据,以有效减少不良妊娠结局。
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引用次数: 0
Maternal intimate partner violence and under five mortality in India: The effect modifying role of caste 印度母亲亲密伴侣暴力和五岁以下儿童死亡率:种姓的影响和调节作用。
IF 3.2 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-17 DOI: 10.1016/j.puhe.2025.106099
Aditi Roy , Gavin Pereira , Jennifer Dunne , Sylvester Dodzi Nyadanu , Gizachew A. Tessema

Objectives

In a country such as India where caste systems deeply influence social dynamics, caste systems could modify the association between experiencing intimate partner violence (IPV) and maternal and child health and wellbeing. This study aimed to investigate the association between IPV and child mortality across various caste groups.

Study design

The study has a cross-sectional design drawn from the two latest available nationally representative National Family Health Surveys data (2015–2021) in India.

Methods

This study included 58,685 mother-child pairs. In the study, the main exposure variable was IPV, measured by women's experiences of emotional, physical, and sexual violence perpetrated by a partner, with caste considered as an effect modifier in the analysis. The outcomes of the study included under five mortality. By accounting for women's and child demographics, logistic regression analysis was used to estimate adjusted odds ratios (aOR) for the association between IPV and infant, neonatal, and under-five mortality stratified by caste.

Results

Women who had experienced IPV had 16 % greater odds of neonatal mortality (1.16, 95 % CI: 1.10–1.23), 17 % greater odds of infant mortality (1.17, 95 % CI: 1.03, 1.33), and 12 % greater odds of under-five mortality (1.12; 95 % CI: 0.98, 1.18). When stratified by caste, IPV exposure among women from upper castes had a 68 % greater in the odds of neonatal mortality (aOR: 1.68, 95 % CI: 1.22, 2.29), 24 % greater odds of infant mortality (1.24, 95 % CI: 1.02, 1.80), and 40 % greater odds of under-five mortality (aOR: 1.40, 95 % CI: 1.09, 1.81). Notably, among lower-caste groups, we observed greater odds of under-five mortality among women who experienced IPV in STs group compared to SCs and OBCs.

Conclusion

IPV is associated positively with neonatal, infant, and under-five mortalities with greater effect in upper than lower caste women. Our findings suggest that addressing IPV in caste-specific situations may be crucial for reducing under-five mortality in India.
目标:在种姓制度深刻影响社会动态的印度等国家,种姓制度可以改变遭受亲密伴侣暴力(IPV)与妇幼健康和福祉之间的联系。本研究旨在调查不同种姓群体中IPV与儿童死亡率之间的关系。研究设计:该研究采用横断面设计,取自印度最新的两项具有全国代表性的全国家庭健康调查数据(2015-2021)。方法:本研究纳入58,685对母子。在这项研究中,主要的暴露变量是IPV,通过女性遭受伴侣施加的情感、身体和性暴力的经历来衡量,种姓被认为是分析中的一个影响调节因素。研究结果包括五岁以下儿童的死亡率。通过考虑妇女和儿童人口统计数据,采用logistic回归分析来估计IPV与按种姓分层的婴儿、新生儿和五岁以下儿童死亡率之间的关系的调整优势比(aOR)。结果:经历过IPV的妇女新生儿死亡率高出16% (1.16,95% CI: 1.10-1.23),婴儿死亡率高出17% (1.17,95% CI: 1.03, 1.33),五岁以下儿童死亡率高出12% (1.12;95% CI: 0.98, 1.18)。当按种姓分层时,高种姓妇女暴露于IPV的新生儿死亡率高出68% (aOR: 1.68, 95% CI: 1.22, 2.29),婴儿死亡率高出24% (aOR: 1.24, 95% CI: 1.02, 1.80),五岁以下儿童死亡率高出40% (aOR: 1.40, 95% CI: 1.09, 1.81)。值得注意的是,在低种姓群体中,我们观察到,与SCs和OBCs相比,STs组中经历IPV的5岁以下妇女死亡率更高。结论:IPV与新生儿、婴儿和五岁以下儿童死亡率呈正相关,高种姓妇女比低种姓妇女的影响更大。我们的研究结果表明,在特定种姓的情况下解决IPV问题可能对降低印度五岁以下儿童死亡率至关重要。
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