Neurology Psychiatry and Brain Research最新文献_第5页

Platelet mass index as an indicator of platelet activation in manic episode 血小板质量指数作为躁狂发作血小板活化的指标

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-09-01 Epub Date: 2020-05-26 DOI: 10.1016/j.npbr.2020.04.004

Aysu Kara , Nesrin Karamustafalioglu , Tevfik Kalelioglu , Abdullah Genc , Murat Emul

Background

Discovering the biological basis of bipolar disorder has been the focus of studies in recent years. Alterations in platelet parameters were found to be associated with episodes of bipolar disorder. This study aimed to compare the differences in platelet parameters especially the platelet mass index as an inflammation marker between the patients with bipolar mania and healthy controls.

Methods

68 male inpatients with manic episodes and 60 age-gender matched healthy controls were included in the study. Platelet mass index, mean platelet volume and platelet counts were compared between controls and manic patients.

Results

Platelet mass index of manic group was significantly higher than the controls (p = 0.002). Statistically signiﬁcant difference was also observed between groups in terms of mean platelet volume (p = 0.012). For platelet counts; there was no statistically significant difference between manic and control groups (p = 0.171).

Limitation

The limitations of this study is that, platelet mass index was not measured in manic patients after manic episodes subsided. Other limitations are relatively small sample size, cross-sectional nature and lacking the data about other inflammation and cardiovascular marker, and lack of the longitudinal outcomes of multiple drugs and effects of lifestyle factors.

Conclusion

Platelet mass index reflects platelet functionality and is thought to be a useful parameter for plaque formation capacity of platelets. In our study, we have shown an increment in platelet activation in manic episode compared to healthy controls; which may reflect the inflammation process and cardiovascular status in bipolar disorder.

发现双相情感障碍的生物学基础是近年来研究的重点。血小板参数的改变被发现与双相情感障碍的发作有关。本研究旨在比较双相躁狂症患者与健康对照者血小板参数的差异，尤其是血小板质量指数作为炎症标志物。方法选取68例男性住院躁狂发作患者和60例年龄性别匹配的健康对照。比较对照组与躁狂患者的血小板质量指数、平均血小板体积和血小板计数。结果躁狂组血小板质量指数显著高于对照组(p = 0.002)。各组平均血小板体积差异有统计学意义(p = 0.012)。用于血小板计数;躁狂组与对照组比较，差异无统计学意义(p = 0.171)。局限性本研究的局限性在于，未在躁狂发作消退后测量躁狂患者的血小板质量指数。其他限制是样本量相对较小，横断面性质，缺乏其他炎症和心血管标志物的数据，缺乏多种药物的纵向结果和生活方式因素的影响。结论血小板质量指数可反映血小板功能，是衡量血小板血小板形成能力的重要指标。在我们的研究中，我们发现与健康对照相比，躁狂发作时血小板活化增加;这可能反映了双相情感障碍的炎症过程和心血管状态。

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引用次数: 1

Neurological manifestations of COVID-19 and other coronaviruses: A systematic review COVID-19和其他冠状病毒的神经学表现:系统综述

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-09-01 Epub Date: 2020-05-31 DOI: 10.1016/j.npbr.2020.05.008

Alyne Oliveira Correia , Pedro Walisson Gomes Feitosa , Jorge Lucas de Sousa Moreira , Samuel Átila Rodrigues Nogueira , Ricardo Brandão Fonseca , Maria Elizabeth Pereira Nobre

Objective

To describe the main neurological manifestations related to coronavirus infection in humans.

Methodology

A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: “coronavirus” or “Sars-CoV-2” or “COVID-19” and “neurologic manifestations” or “neurological symptoms” or “meningitis” or “encephalitis” or “encephalopathy,” following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

Seven studies were included. Neurological alterations after CoV infection may vary from 17.3% to 36.4% and, in the pediatric age range, encephalitis may be as frequent as respiratory disorders, affecting 11 % and 12 % of patients, respectively. The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. The main neurological alterations were headache (69; 16.8 %), dizziness (57, 13.9 %), altered consciousness (46; 11.2 %), vomiting (26; 6.3 %), epileptic crises (7; 1.7 %), neuralgia (5; 1.2 %), and ataxia (3; 0.7 %). The main presumed diagnoses were acute viral meningitis/encephalitis in 25 (6.1 %) patients, hypoxic encephalopathy in 23 (5.6 %) patients, acute cerebrovascular disease in 6 (1.4 %) patients, 1 (0.2 %) patient with possible acute disseminated encephalomyelitis, 1 (0.2 %) patient with acute necrotizing hemorrhagic encephalopathy, and 2 (1.4 %) patients with CoV related to Guillain-Barré syndrome.

Conclusion

Coronaviruses have important neurotropic potential and they cause neurological alterations that range from mild to severe. The main neurological manifestations found were headache, dizziness and altered consciousness.

目的探讨人冠状病毒感染的主要神经学表现。方法系统回顾与新冠病毒及其他冠状病毒相关的神经学表现病例的临床研究。检索在PubMed、Scopus、Embase和LILACS电子数据库中进行，检索关键词为:“冠状病毒”或“Sars-CoV-2”或“COVID-19”和“神经系统表现”或“神经系统症状”或“脑膜炎”或“脑炎”或“脑病”，检索遵循系统评价和荟萃分析(PRISMA)指南。结果共纳入7项研究。冠状病毒感染后的神经系统改变可能从17.3%到36.4%不等，在儿科年龄段，脑炎可能与呼吸系统疾病一样常见，分别影响11%和12%的患者。该调查包括409例诊断为冠状病毒感染并出现神经系统症状的患者，中位年龄范围从3岁到62岁不等。主要的神经系统改变是头痛(69;16.8%)，头晕(57例，13.9%)，意识改变(46例;11.2%)，呕吐(26%);6.3%)，癫痫危象(7;1.7%)，神经痛(5%;1.2%)，共济失调(3;0.7%)。主要推定诊断为急性病毒性脑膜炎/脑炎25例(6.1%)，缺氧脑病23例(5.6%)，急性脑血管病6例(1.4%)，可能合并急性播散性脑脊髓炎1例(0.2%)，急性坏死性出血性脑病1例(0.2%)，格林-巴-罗综合征相关冠状病毒2例(1.4%)。结论冠状病毒具有重要的嗜神经潜能，可引起从轻度到重度的神经系统改变。主要的神经学表现为头痛、头晕和意识改变。

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引用次数: 112

Globalization, internet and psychiatric disorders: Call for research and action in global mental health 全球化、互联网和精神疾病:呼吁在全球精神卫生方面进行研究和采取行动

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-02-21 DOI: 10.1016/j.npbr.2020.02.007

Jude Mary Cénat

Background

Studies have largely analyzed the association between globalization and mental health. However, the main focus has been on the challenges of migration trauma and living together into multicultural societies. Yet, Internet-related mental disorders are poorly studied, while Internet, as the main tool of 21st century globalization, is reconceptualizing psychiatric illnesses.

Aims

This current debate paper discusses the association between globalization, Internet and mental disorders. It aims to stimulate a current, important, urgent and necessary debate to integrate this important characteristic of globalization in the genesis, etiology, and treatment of mental disorders.

Observations

Although studies have been conducted on the relation between mental health and Internet (cyberbullying, online gambling addiction, cyberdependence, etc.), none has integrated globalization in their analysis. Similarly, Internet-related traumas are less explored, while traumatic images from the Internet are increasingly present in the children, adolescents and adults’ lives. Also, globalization is based primarily on the interconnectedness of institutions, populations and individuals and plays an increasingly key role in the individuals’ life. The resulted hyperconnectivity is bringing new mental disorders, reconceptualizing others and, above all, can obsolete mental disorder classification manuals if the various factors associated with it are not integrated.

Conclusions

This study shows that it is important to adapt our tools for assessing, classifying and describing mental disorders in the light of this new reality of globalization. With a perspective both as a researcher and a clinician, it shows research and action options needed before the train is too far away and difficult to catch.

研究主要分析了全球化与心理健康之间的关系。然而，主要的焦点是移徙的创伤和在多元文化社会中共同生活的挑战。然而，与互联网相关的精神障碍研究很少，而互联网作为21世纪全球化的主要工具，正在重新定义精神疾病。目的:本文讨论了全球化、互联网和精神障碍之间的关系。它旨在激发一场当前的、重要的、紧迫的和必要的辩论，将全球化的这一重要特征整合到精神障碍的发生、病因和治疗中。虽然对心理健康与网络(网络欺凌、网络赌博成瘾、网络依赖等)之间的关系进行了研究，但没有一项研究将全球化纳入其分析。同样，与互联网相关的创伤较少被探索，而来自互联网的创伤图像越来越多地出现在儿童、青少年和成年人的生活中。此外，全球化主要基于机构、人口和个人的相互联系，并在个人生活中发挥着越来越重要的作用。由此产生的超连通性带来了新的精神障碍，重新定义了其他人，最重要的是，如果不整合与之相关的各种因素，可能会使精神障碍分类手册过时。这项研究表明，根据全球化的新现实，调整我们评估、分类和描述精神障碍的工具是很重要的。从研究人员和临床医生的角度来看，它展示了在火车太远而难以赶上之前需要进行的研究和行动选择。

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引用次数: 2

Cytokine changes in different types of depression: Specific or general? 不同类型抑郁症的细胞因子变化:特异性还是普遍性?

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-02-29 DOI: 10.1016/j.npbr.2020.02.009

Haoyin Wang , Peng Li , Yongping Zhang , Cai Zhang , Kangwei Li , Cai Song

Background

Various cytokine changes have been reported in patients with different types of depression. However, it is unclear whether depression is a consequence of brain general response to chronic or severe immune inflammation, or specific cytokine changes contribute to a different subtype of depression.

Methods

Two terms (cytokine OR inflammation) AND (subtype of depression) from Pubmed were used to select the patients with first-episode or drug-free. A total of 39 articles in 7 subtypes of depression were selected and included in the review.

Results

M1 and T helper (Th) 1 pattern dominates in major depression, such as increased interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ, but reduced IL-10. Similarly, M1 cytokines IL-1β, IL-6 and TNF-α are increased except for transforming growth factor in bipolar disorder, and IL-1β, IL-6, TNF-α and IFN-γ increased in seasonal affective disorder. However, a certain cytokine change is correlated to a subtype of depression. For example, pro-inflammatory cytokines are altered during different period of prenatal and postpartum depression. Th phenotypes difference between atypical depression and melancholic depression is related to IL-2 and IL-4. As well, higher levels of IL-6 and lower IL-2 in suicide attempters compared to non-suicidal, etc.

Limitations

Studies in specific depression were not enough. Inconsistent investigation designs and results were reported in different subtypes of depression.

Conclusions

A certain immune/cytokine pattern may be related to a subtype of depression. However, Big Data Analysis and Precision Medicine should be utilized to figure out the real connection between cytokine changes and depression.

不同类型的抑郁症患者中存在不同的细胞因子变化。然而，目前尚不清楚抑郁症是大脑对慢性或严重免疫炎症的一般反应的结果，还是特定的细胞因子变化导致了不同亚型的抑郁症。方法采用Pubmed中的两个术语(细胞因子或炎症)和(抑郁症亚型)来选择首发或无药患者。共选择7种抑郁症亚型的39篇文献纳入本综述。结果重度抑郁症患者以sm1和辅助性T细胞(Th) 1模式为主，表现为白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α和干扰素(IFN)-γ升高，IL-10降低。同样，M1细胞因子IL-1β、IL-6和TNF-α在双相情感障碍中除了转化生长因子外升高，IL-1β、IL-6、TNF-α和IFN-γ在季节性情感障碍中升高。然而，某种细胞因子的变化与抑郁症的一种亚型有关。例如，促炎细胞因子在产前和产后抑郁的不同时期发生改变。非典型抑郁症与抑郁型抑郁症的表型差异与IL-2和IL-4有关。此外，与非自杀者相比，自杀未遂者的IL-6水平较高，IL-2水平较低。不同亚型抑郁症的调查设计和结果不一致。结论某种免疫/细胞因子模式可能与抑郁症亚型有关。但是，应该利用大数据分析和精准医疗来找出细胞因子变化与抑郁症之间的真正联系。

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引用次数: 4

Functional connectivity changes in patients with brain tumours—A systematic review on resting state-fMRI 脑肿瘤患者的功能连接改变——静息状态fmri的系统综述

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-04-16 DOI: 10.1016/j.npbr.2020.03.003

Hanani Abdul Manan , Elizabeth A. Franz , Noorazrul Yahya

Aim

Resting-state functional magnetic resonance imaging (rs-fMRI) has been utilised to explore the brain's functional changes in patients with brain tumours. However, it remains unclear how such alterations affect functional connectivity (FC) and thus lead to changes in behaviour. To better understand the present state of knowledge, we conducted a systematic review.

Material and methods

A systematic literature search of patients with brain tumours with rs-fMRI methods was conducted using the PubMed/MEDLINE and Cochrane Library electronic databases following PRISMA guidelines. References and citations were checked in Scopus database.

Results

Ten independent studies were identified, comprising of 361 adult participants (218 had brain tumours; and the remainder were healthy controls). In comparison to healthy controls, patients with brain tumours demonstrated network distortions, alterations, and associated changes in the resting state networks (RSNs). Location and types of tumour affected RSNs integrity, particularly in the Default Mode Network (DMN). The left hemisphere was reported to have the largest effect on RSNs regardless of size or type of tumour. Result also demonstrate significant alterations to the local networks (decreases in the intra-hemispheric and inter-hemispheric FC). Studies also demonstrated that alterations in rs-fMRI were related to poorer neuropsychological task performance.

Conclusion

However, more studies utilising rs-fMRI to investigate effects of brain tumours on different types of RSNs are needed to draw clear conclusions about effects of tumour growth on properties of brain functional networks. Notably, not all studies have used the same nodes or regions for the networks, even though tumour locations often overlap.

静息状态功能磁共振成像(rs-fMRI)已被用于探索脑肿瘤患者的大脑功能变化。然而，目前尚不清楚这种改变如何影响功能连接(FC)，从而导致行为的改变。为了更好地了解知识的现状，我们进行了系统的回顾。材料和方法按照PRISMA指南，使用PubMed/MEDLINE和Cochrane图书馆电子数据库，对脑肿瘤患者进行rs-fMRI方法的系统文献检索。参考文献和引文在Scopus数据库中进行了检查。结果确定了10项独立研究，包括361名成年参与者(218名患有脑肿瘤;其余为健康对照组)。与健康对照相比，脑肿瘤患者在静息状态网络(rsn)中表现出网络扭曲、改变和相关变化。肿瘤的位置和类型影响rsn的完整性，特别是在默认模式网络(DMN)中。据报道，无论肿瘤大小或类型如何，左半球对rsn的影响最大。结果还显示了局部网络的显著改变(半球内和半球间FC的减少)。研究还表明，rs-fMRI的改变与较差的神经心理任务表现有关。结论肿瘤生长对脑功能网络特性的影响尚需更多利用rs-fMRI研究脑肿瘤对不同类型rsn的影响。值得注意的是，并不是所有的研究都使用相同的节点或区域作为网络，即使肿瘤的位置经常重叠。

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引用次数: 15

Oxidative stress, antioxidant defense and depressive disorders: A systematic review of biochemical and molecular markers 氧化应激、抗氧化防御和抑郁症:生化和分子标记的系统综述

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-04-10 DOI: 10.1016/j.npbr.2020.02.006

Maiza Lacerda Barbosa , Ag-Anne Pereira Melo de Meneses , Rai Pablo Sousa de Aguiar , João Marcelo de Castro e Sousa , Ana Amélia de Carvalho Melo Cavalcante , Sharbel Weidner Maluf

Background

Oxidative stress (OS) can contribute to the development of several diseases, including depressive disorders (DD). Antioxidant therapy been an important tool to depressive disorders or to side effects of the current therapy. This systematic review aimed to correlate the biochemical and molecular biomarkers of oxidative stress and antioxidant defenses with depressive disorders, through the evaluation of clinical studies.

Methods

The literature were obtained from the PubMed, Scielo, VHL, Medline and Scopus databases with the descriptors [depressive disorders], [vitamin antioxidants], [vitamin C], [retinol palmitate], [vitamin A] and [depression], combined.

Results

Several biomarkers of oxidative damage that affect biomolecules such as DNA, RNA, proteins and lipids and antioxidant defense biomarkers were analyzed in 28 articles selected by the the inclusion criteria. The biomarkers found were 8-OHdG, 3-NT, PCC, F2-Iso, 4-HNE, 8-Iso, MDA, SOD, CAT, GPx and vitamins A and C.

Conclusions

Most of the studies found significant associations between these biomarkers, depressive disorders. Thus, there are many perspectives for further studies that can clarify the relation of these biomarkers with depressive disorders.

Limitations

The scarce literature that fit the inclusion criteria may have limited this review.

背景氧化应激(OS)可促进多种疾病的发展，包括抑郁症(DD)。抗氧化治疗是目前治疗抑郁症或其副作用的重要手段。本系统综述旨在通过对临床研究的评估，将氧化应激和抗氧化防御的生化和分子生物标志物与抑郁症联系起来。方法从PubMed、Scielo、VHL、Medline和Scopus数据库中获取文献，文献描述词为[抑郁症]、[维生素抗氧化剂]、[维生素C]、[视黄醇棕榈酸酯]、[维生素A]和[抑郁症]。结果根据纳入标准选取了28篇文献，分析了几种影响DNA、RNA、蛋白质、脂质等生物分子的氧化损伤生物标志物和抗氧化防御生物标志物。发现的生物标志物有8-OHdG、3-NT、PCC、F2-Iso、4-HNE、8-Iso、MDA、SOD、CAT、GPx和维生素A和c。结论大多数研究发现这些生物标志物与抑郁症之间存在显著相关性。因此，有许多进一步的研究可以阐明这些生物标志物与抑郁症的关系。局限性:符合纳入标准的文献稀少可能限制了本综述。

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引用次数: 27

Iloperidone-induced urinary incontinence in a female patient with schizophrenia: A case report 依哌啶酮致女性精神分裂症患者尿失禁1例

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-04-22 DOI: 10.1016/j.npbr.2020.04.001

S.M. Yasir Arafat

Background

Iloperidone, a second-generation antipsychotic has been approved for the management of schizophrenia. Although it has been found well-tolerated multiple side effects have been reported.

Objectives

I report a case of iloperidone-induced urinary incontinence in a Bangladeshi female.

Method

This patient has been taking psychiatric consultations for the last five years. After developing the side effect, informed consent was taken, details of history were obtained, and routine physical examination and mental status of the patient was performed.

Results

I report a case of 20 years old female who developed urinary incontinence due to iloperidone. Her symptoms improved after discontinuing the drug.

Conclusion

This is the first case, reporting urinary incontinence caused by iloperidone in a patient with schizophrenia which could be an effect of bladder neck dysfunction due to the high alpha 1 receptor blockade.

哌啶酮是第二代抗精神病药物，已被批准用于治疗精神分裂症。虽然它的耐受性很好，但据报道有多种副作用。目的报告一例依哌啶酮引起的孟加拉女性尿失禁。方法患者近5年接受精神科会诊。出现副作用后，接受知情同意，详细了解病史，对患者进行常规体检和精神状态检查。结果报告1例20岁女性因服用依哌啶酮而发生尿失禁。停药后她的症状好转了。结论这是首例报告的伊哌啶酮引起的精神分裂症患者尿失禁，可能是由于高α 1受体阻断引起的膀胱颈功能障碍所致。

引用次数: 0

Characteristics, methods and precipitating events of suicidal behaviors in Bangladesh: A year-round content analysis of six national newspapers 孟加拉国自杀行为的特点、方法和诱发事件：对六家全国性报纸的全年内容分析

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-02-19 DOI: 10.1016/j.npbr.2020.02.005

S.M. Yasir Arafat , Bithika Mali , Hasina Akter

Background

Epidemiological aspect of suicidal behaviors is an under-researched matter in Bangladesh.

Objectives

It was aimed to see the characteristics, methods and precipitating events of suicidal behaviors by analyzing the contents of national daily newspapers of Bangladesh.

Methods

We analyzed the published contents of six daily newspapers that were collected and hand-searched between 01 November 2018 and 31 October 2019. A total of 403 articles were collected and subsequently analyzed.

Results

The mean age of suicide victims reported in these newspapers was 25.81 ± 11.62 years (Range: 8–80 years). More than fifty percent of the reported cases were less than 30 years of age, 55.6 % were female, 33.25 % were students, and 48.4 % were married. Hanging was found as the commonest method (76 %) and marital discords (14.89 %), familial discords (9.68 %), sexual issues (9.18 %), affair related issues (5.71 %), were found as the mentionable precipitating events. Year-round tracing of suicides based on the reports revealed peaks in April and November.

Conclusion

The study showed adults less than thirty years, females, and students are exhibiting more suicidal behaviors. Hanging was the most commonly used method and the majority of the precipitating events were within the family.

背景自杀行为的流行病学方面在孟加拉国是一个研究不足的问题。目的通过分析孟加拉国全国性日报的内容，了解自杀行为的特点、方法和诱发事件。方法对2018年11月1日至2019年10月31日收集并手工检索的6份日报发表内容进行分析。共收集并分析了403篇文章。结果自杀者平均年龄为25.81±11.62岁(范围8 ~ 80岁)。超过50%的报告病例年龄在30岁以下，55.6%为女性，33.25%为学生，48.4%为已婚。最常见的自杀方式是上吊(76%)，其次是婚姻不和(14.89%)、家庭不和(9.68%)、性问题(9.18%)、外遇相关问题(5.71%)。基于报告的全年自杀追踪显示，4月和11月是自杀高峰。结论研究显示，30岁以下的成年人、女性和学生表现出更多的自杀行为。绞刑是最常用的方法，而且大多数的突发事件发生在家庭内部。

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引用次数: 8

Association of clinical features and biomarkers with treatment-resistant depression 临床特征和生物标志物与难治性抑郁症的关系

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2020-02-28 DOI: 10.1016/j.npbr.2020.02.004

Ana Carolina Congio MD , Maisa Norcia MD , Mariana Ragassi Urbano PhD , Waldiceu A. Verri Jr PhD , Sandra Odebrecht Vargas Nunes PhD

Background

Treatment-resistant depression (TRD) is associated with inflammatory biomarkers, childhood maltreatment, suicidal behaviour and functional impairment.

Methods

Our sample was divided in 3 groups. TRD group was considered with a 17-item Hamilton Depression Rating Scale (HDRS₁₇) for depression score remaining greater to 16 after 2 consecutive adequate treatment for bipolar disorder (BD) or major depressive disorder (MDD) (n = 24), non-TRD (n = 120) group and controls (n = 82). Socio-demographic and clinical data were assessed by structured questionnaire. Other assessments used were body mass index (BMI), Sheehan Disability Scale and Childhood Trauma Questionnaire. Laboratory biomarkers were leptin and high-sensitivity C-reactive protein (hs-CRP).

Results

The clinical features associated with TDR group were earlier at onset of first episode, increased number of depressive episodes, higher lifetime suicide attempts and comorbidities with panic disorder and PTSD. TRD group was more likely to have disability for work (OR = 8.20) and underproductive days (OR = 1.09) than non-TRD and control groups. Higher levels of leptin, hs-CRP > 3 mg/L and higher BMI were also found to be associated with TRD. The TRD patients with hs-CRP > 3 mg/L presented on average higher levels of leptin for the same BMI, compared to non-TRD.

Limitation

Retrospective assessment to investigate child abuse could be based on recall bias.

Conclusions

These findings suggest TRD is associated with earlier onset age, more depressive episodes and suicide attempts, comorbidities and functional impairment. TRD patients also should be assessed to comorbidities, childhood sexual abuse and increased levels of CRP and leptin.

背景:难治性抑郁症(TRD)与炎症生物标志物、儿童虐待、自杀行为和功能障碍有关。方法将样品分为3组。TRD组在双相情感障碍(BD)或重度抑郁症(MDD) (n = 24)、非TRD组(n = 120)和对照组(n = 82)连续2次充分治疗后，采用17项汉密尔顿抑郁评定量表(HDRS17)评定抑郁评分高于16分。采用结构化问卷对社会人口学和临床资料进行评估。其他评估方法包括身体质量指数(BMI)、Sheehan残疾量表和儿童创伤问卷。实验室生物标志物为瘦素和高敏c反应蛋白(hs-CRP)。结果TDR组的临床特征为首次发作时间提前，抑郁发作次数增加，终生自杀企图增多，并伴有惊恐障碍和创伤后应激障碍。与非TRD组和对照组相比，TRD组更有可能出现工作残疾(OR = 8.20)和工作不足天数(OR = 1.09)。瘦素、hs-CRP水平升高;3毫克/升和更高的BMI也与TRD有关。TRD患者hs-CRP;与非trd相比，在相同的体重指数下，3mg /L的人瘦素水平平均更高。局限性调查儿童虐待的回顾性评估可能基于回忆偏差。结论TRD与发病年龄早、抑郁发作和自杀倾向多、合并症和功能障碍有关。TRD患者还应评估合并症、儿童期性虐待以及CRP和瘦素水平升高。

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引用次数: 7

Corrigendum to “Celecoxib augmentation of escitalopram in treatment-resistant bipolar depression and the effects on Quinolinic Acid” [Neurology, Psychiatry and Brain Research 32 (2019) June 22–29] “塞来昔布增强艾司西酞普兰治疗难治性双相抑郁症及其对喹啉酸的影响”的勘误表[神经病学，精神病学和脑研究32 (2019)June 22-29]

Q3 Medicine

Neurology Psychiatry and Brain Research

Pub Date : 2020-06-01 Epub Date: 2019-11-13 DOI: 10.1016/j.npbr.2019.10.005

Monica Feliz R. Castillo , Stephen Murata , Markus Schwarz , Gregor Schütze , Natalie Moll , Brendan Martin , Bianca Burger , Elif Weidinger , Norbert Mueller , Angelos Halaris

引用次数: 2