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[Goodbye-Valued members of the German Society for Neurology]. [再见--德国神经病学学会的宝贵成员]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1007/s00115-024-01783-6
Jürgen M Meyer Zu Tittingdorf, Martin Grond
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引用次数: 0
Mitteilungen der DGN. DGN通讯。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 DOI: 10.1007/s00115-024-01782-7
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引用次数: 0
[Characterization of a German cohort with visual snow syndrome]. [德国一组视觉雪综合症患者的特征]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1007/s00115-024-01768-5
Felix Fay, Andreas Straube, Ruth Ruscheweyh, Ozan Emre Eren

Background: Visual snow is a disorder of visual perception that is manifested as a constant flickering or "TV-like" noise in the entire visual field. Visual snow syndrome (VSS) describes a combination with other additional visual symptoms, such as sensitivity to light, afterimages, night blindness and entoptic phenomena. Cases of VS have been described in the literature using a wide variety of terms, often misunderstood as persistent migraine aura. Established diagnostic criteria have existed for more than 10 years now; however, the pathophysiology is still incompletely understood. The exact prevalence also remains unknown and high numbers of unreported cases are suspected. This is the first detailed description of a cohort of VSS patients from Germany.

Methods: Patients with VSS from several studies conducted at our center were pooled and retrospectively evaluated with respect to demographic, epidemiological and clinical data.

Results: In this study 66 patients with VSS were included (age 31.3 ± 8.3 years, 30 women). The most commonly associated visual symptoms were photophobia (67%) and afterimages (65%). Of the patients 36 (54%) had comorbid migraine of whom 25 (70%) had migraine with aura, 26 (39%) reported depressive symptoms and 32 (48%) symptoms of an anxiety disorder. Tinnitus was reported by 32 (48%) patients.

Conclusion: The characteristics of the German cohort described here are similar to other international descriptions. Due to the frequent psychological comorbidity there is still a risk of psychosomatic stigmatization.

背景:视觉雪花症是一种视觉感知障碍,表现为整个视野中出现持续闪烁或 "电视样 "噪音。视雪综合征(VSS)是一种与其他视觉症状(如对光敏感、残像、夜盲症和内视现象)相结合的综合征。文献中对视觉雪综合征病例的描述术语繁多,常常被误解为持续性偏头痛先兆。既定的诊断标准已经存在了 10 多年,但对其病理生理学的了解仍不全面。确切的发病率也仍然未知,怀疑有大量未报告的病例。本文首次详细描述了德国的一组 VSS 患者:方法:将本中心开展的几项研究中的 VSS 患者集中起来,对其人口统计学、流行病学和临床数据进行回顾性评估:本研究共纳入 66 名 VSS 患者(年龄为 31.3 ± 8.3 岁,30 名女性)。最常见的相关视觉症状是畏光(67%)和余像(65%)。患者中有 36 人(54%)合并偏头痛,其中 25 人(70%)有先兆偏头痛,26 人(39%)有抑郁症状,32 人(48%)有焦虑症症状。32名(48%)患者有耳鸣症状:结论:本文描述的德国队列的特征与其他国际描述相似。结论:本文描述的德国患者群的特征与其他国际描述相似,但由于经常出现心理并发症,因此仍存在心身疾病污名化的风险。
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引用次数: 0
Erratum zu: Periphere neuroimmunologische Erkrankungen – neuropathologische Einsichten und klinische Perspektiven. 外周神经免疫疾病--神经病理学见解和临床视角》勘误。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 DOI: 10.1007/s00115-024-01761-y
Sarah Hoffmann, Marie-Therese Holzer, Corinna Preuße, Tobias Ruck, Nikolas Ruffer, Frauke Stascheit, Werner Stenzel
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引用次数: 0
[Parenthood and mental diseases]. [为人父母与精神疾病]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-26 DOI: 10.1007/s00115-024-01781-8
Anne Koopmann, Andreas Hoell, Andreas Meyer-Lindenberg, Falk Kiefer, Tobias Banaschewski, Alexander Haege, Sabine C Herpertz, Corinne Neukel, Louise Poustka, Tobias Link, Jutta Kammerer-Ciernioch, Matthias C Michel, Birgit Karl, Iris Graeff Calliess, Martin Holzke, Anna Kaiser, Isabel Ardern, Nina Christmann, Leonie Scharmann, Yvonne Grimmer
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引用次数: 0
[Cognitive impairments associated with schizophrenic psychoses : Diagnostics, course and therapy]. [与精神分裂症精神病相关的认知障碍:诊断、病程和治疗]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-26 DOI: 10.1007/s00115-024-01773-8
Lana Kambeitz-Ilankovic, Wolfgang Strube, Bernhard T Baune, Peter Falkai, Lukas Röll, Stefan Leucht

Background: Longitudinal outcome studies confirm that the majority of patients with schizophrenic psychoses develop cognitive impairments associated with schizophrenia (CIAS).

Objective: To provide an overview of the epidemiology, diagnostics and evidence for various treatment options for CIAS.

Material and methods: Literature review of the current level of evidence regarding the efficacy of different treatment strategies for CIAS.

Results: Up to 85% of patients with schizophrenic psychoses exhibit CIAS, in some cases even before the development of positive or negative symptoms. The CIAS are associated with extensive individual burden due to impairments in many areas of cognitive and psychosocial functioning relevant to daily life. Various test instruments are available for clinical assessment with the Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) consensus cognitive battery (MCCB) as an established standard for clinical trials and special clinical issues. The treatment of CIAS warrants a multimodal approach with non-drug strategies (e.g., cognitive remediation, exercise) currently providing the best level of evidence. Noninvasive neurostimulation procedures and dopaminergic antipsychotic drugs of the first and second generations have demonstrated low effectiveness on cognitive function disorders in schizophrenic psychoses.

Conclusion: The CIAS is a frequent disease-immanent symptom in schizophrenic psychoses that should be considered in the clinical routine as it substantially impairs those affected in the functional level and quality of life. Current treatment options are limited but innovative psychosocial interventions show low to moderate effects. In addition, new medications developed based on current neurobiological findings and combinations with psychosocial and neurostimulation procedures could open up new perspectives.

背景:纵向结果研究证实,大多数精神分裂症患者会出现与精神分裂症相关的认知障碍(CIAS):概述 CIAS 的流行病学、诊断和各种治疗方案的证据:对目前有关 CIAS 不同治疗策略疗效的证据进行文献综述:多达85%的精神分裂症患者表现出CIAS,在某些情况下,甚至在出现阳性或阴性症状之前就有CIAS。由于与日常生活相关的认知和社会心理功能的许多方面都出现了障碍,CIAS 给患者带来了巨大的个人负担。目前有多种测试工具可用于临床评估,其中心理健康的 "改善精神分裂症认知的测量和治疗研究"(MATRICS)共识认知电池(MCCB)是临床试验和特殊临床问题的既定标准。对 CIAS 的治疗需要采用多模式方法,而非药物策略(如认知矫正、运动)目前提供了最佳证据。非侵入性神经刺激程序以及第一代和第二代多巴胺能抗精神病药物对精神分裂症患者认知功能障碍的疗效较低:CIAS是精神分裂症精神病中一种常见的疾病伴随症状,由于它严重影响患者的功能水平和生活质量,因此应在临床常规治疗中予以考虑。目前的治疗方案有限,但创新的社会心理干预措施显示出低到中等程度的效果。此外,根据目前的神经生物学研究成果开发的新药物,以及与社会心理治疗和神经刺激程序的结合,也可以开辟新的前景。
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引用次数: 0
[Emergency intervention plans for treatment of suicidal patients: a narrative literature review]. [治疗有自杀倾向病人的紧急干预计划:叙事性文献综述]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-17 DOI: 10.1007/s00115-024-01763-w
Tobias Teismann, Peter Brieger, Hermann Spießl, Lena Marie Hensel, Johannes Hamann

Background: Safety or emergency plan interventions, i.e., the creation of a list of hierarchically organized strategies and persons/institutions that patients can use or contact in case of a suicidal escalation, are increasingly used in clinical practice.

Method: This narrative review describes the approach for establishing an emergency plan and discusses studies on the effectiveness of such interventions. In addition, ideas on the mode of action of corresponding interventions and application variants are discussed.

Results: Despite increasing dissemination of safety plans, empirical evidence of their effectiveness is currently inadequate.

Discussion: High-quality studies are urgently needed, particularly with respect to different clinical populations. At this point in time, it should be cautioned against understanding the creation of an emergency plan as a sufficient intervention in dealing with suicidal patients.

背景:安全或应急计划干预,即创建一份分级组织的策略和人员/机构清单,供患者在自杀行为升级时使用或联系,越来越多地应用于临床实践:这篇叙述性综述介绍了建立应急计划的方法,并讨论了有关此类干预措施有效性的研究。此外,还讨论了相应干预措施的作用模式和应用变体:结果:尽管安全计划的传播日益广泛,但目前有关其有效性的经验证据不足:讨论:迫切需要进行高质量的研究,特别是针对不同临床人群的研究。目前,在处理有自杀倾向的患者时,不应将制定应急计划理解为一种充分的干预措施。
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引用次数: 0
[Lethal nitrous oxide]. [致命的一氧化二氮]
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-17 DOI: 10.1007/s00115-024-01780-9
Ulrich Palm, Suzana Mesaric, Maria Epple, Markus Backmund
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引用次数: 0
[The current legal practice of judicial review of restraints]. [对限制措施进行司法审查的现行法律实践]。
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-15 DOI: 10.1007/s00115-024-01779-2
Maximilian Gahr, Bernhard J Connemann, Dominikus Bönsch, Markus Jäger
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引用次数: 0
[Management of complex anxiety disorders-A case for inpatient treatment?] [复杂焦虑症的管理--住院治疗的案例?]
IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-14 DOI: 10.1007/s00115-024-01764-9
K Feldker-Kasperek, J Diemer, P Zwanzger

Background: Anxiety disorders are among the most frequent psychiatric disorders. Although the vast majority of patients in Germany are treated on an outpatient basis, anxiety disorders also play an important role in day care and inpatient care. Among other aspects, this is against the background of comorbidities, treatment-resistant courses or complications such as suicidal ideation.

Material and methods: As part of an evaluation of the basic psychiatric documentation (BADO) data from 894 patients with anxiety disorders treated in a day care or inpatient setting in a German psychiatric community hospital were evaluated over a period of 7 years.

Results: It was found that 89% of the patients had already been treated before admission and that 70% had been under medication prior to admission: patients with panic disorder made up the largest group of patients with 48%. On the date of admission 48% of patients had been treated with a selective serotonin reuptake inhibitor (SSRI) and 37% had received a benzodiazepine. Furthermore, 75% of the patients had psychiatric comorbidities. Somatic illnesses played an important role in 40% of the patients.

Discussion: The present results underline that a significant proportion of patients with anxiety disorders also require inpatient or day care treatment. Most patients had been previously treated and had not responded to therapy in an outpatient setting. Possible consequences with respect to the optimization of outpatient treatment options and the need to maintain day care and inpatient resources for this patient group, are discussed.

背景:焦虑症是最常见的精神疾病之一:焦虑症是最常见的精神疾病之一。虽然在德国,绝大多数患者都在门诊接受治疗,但焦虑症在日间护理和住院治疗中也发挥着重要作用。除其他方面外,这还与合并症、抗药性病程或自杀意念等并发症有关:作为精神病学基本文件(BADO)评估的一部分,我们对德国一家精神病学社区医院日间护理或住院治疗的 894 名焦虑症患者 7 年来的数据进行了评估:结果发现,89% 的患者在入院前已接受过治疗,70% 的患者在入院前已接受过药物治疗:惊恐障碍患者占患者总数的 48%。入院当日,48%的患者接受过选择性血清素再摄取抑制剂(SSRI)治疗,37%的患者接受过苯二氮卓类药物治疗。此外,75%的患者合并有精神疾病。在 40% 的患者中,躯体疾病是重要原因:讨论:本研究结果表明,相当一部分焦虑症患者也需要住院治疗或日间护理治疗。大多数患者曾接受过治疗,但对门诊治疗效果不佳。本文讨论了优化门诊治疗方案的可能后果,以及为这一患者群体保留日间护理和住院资源的必要性。
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