Medical Engineering & Physics最新文献_第9页

Evaluation of vertebrobasilar arterial blood flow during HeartMate3 support via computational fluid dynamics analyses 通过计算流体动力学分析评估HeartMate3支持期间椎基底动脉血流

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-25 DOI: 10.1016/j.medengphy.2025.104423

Selim Bozkurt

Continuous Flow Left Ventricular Assist Devices (CF-LVADs) are used to support the failing left ventricle in patients with end-stage heart failure. CF-LVADs unload the left ventricle continuously and generate non-physiological blood flow in the cardiovascular system, which may cause major complications, including neurological events such as haemorrhagic strokes. Therefore, quantifying the blood velocities and analysing altered blood flow in the cerebral circulation during CF-LVAD support will help to understand the effects of mechanical circulatory support on cerebral blood flow. The aim of this study is to evaluate blood flow in the vertebrobasilar arteries in a healthy condition and heart failure with reduced ejection fraction and during HeartMate 3 CF-LVAD support. Blood velocities and wall shear stresses in the vertebrobasilar arteries were evaluated using Computational Fluid Dynamics analyses for a healthy condition, heart failure with reduced ejection fraction and during HeartMate 3 support. Simulation results showed that time-averaged wall shear stress and relative residence time decrease in the vertebrobasilar arteries in heart failure. HeartMate 3 support provides comparable cerebral arterial average blood flow rates, pressures, time-averaged wall shear stresses and relative residence times to healthy conditions, although wall shear stresses and blood velocities are altered.

连续血流左心室辅助装置（cf - lvad）用于支持终末期心力衰竭患者衰竭的左心室。cf - lvad持续卸载左心室，并在心血管系统中产生非生理性血流，这可能导致主要并发症，包括出血性中风等神经系统事件。因此，量化血流速度和分析在CF-LVAD支持期间脑循环血流的变化将有助于了解机械循环支持对脑血流的影响。本研究的目的是评估健康状态下椎基底动脉的血流量和心力衰竭伴射血分数降低以及在HeartMate 3 CF-LVAD支持期间的血流量。使用计算流体动力学分析对健康状态、射血分数降低的心力衰竭和HeartMate 3支持期间的椎基底动脉血流速度和壁剪切应力进行评估。模拟结果表明，心力衰竭时椎基底动脉壁平均剪应力和相对停留时间降低。HeartMate 3支持提供了与健康状况相当的脑动脉平均血流量、压力、时间平均壁剪切应力和相对停留时间，尽管壁剪切应力和血流速度发生了变化。

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引用次数: 0

Preclinical analysis of a novel short hip-stem design: A finite element model-based investigation 一种新型短髋干设计的临床前分析：基于有限元模型的研究

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI: 10.1016/j.medengphy.2025.104415

Abhik Chaudhuri , Tanmoy Loha , Prashanta Kr Mahato , Andrew A Amis , Bidyut Pal

This study proposes a novel uncemented short hip stem, adapted from a long stem design to reduce strain shielding and bone resorption and improve osseointegration. It consists of a central core of Ti alloy with buttresses (inner solid and outer porous) protruding radially outwards. The slots between the buttresses are filled with bone substitute material. The present study investigated the short-stem's mechanical behaviour, focusing on strain shielding and bone remodelling in short and long terms, respectively. The results were compared to those of the solid counterpart with overall same geometry. Computer Tomography (CT) based 3D FE models of an intact and reconstructed femur were used. The models were solved for two static loading cases: normal walking and stair climbing. Strain shielding was observed across all the Gruen Zones with both the stems; however, to a much lesser extent (

\sim 44 %,

on average) with the porous stem. Subsequent bone resorption was also predicted to be of much lesser degree (

\sim 42 %,

on average) with the porous stem. Furthermore, strain concentration in the bone around the porous stem tip was less prominent than the solid stem, indicating lower risk of thigh pain. The porous short stem design offers promising results, both in short and long terms.

本研究提出了一种新型的非骨水泥短髋关节干，改编自长髋关节干设计，以减少应变屏蔽和骨吸收，并改善骨整合。它由钛合金的中心核心组成，支撑（内部实心，外部多孔）呈放射状向外突出。扶壁之间的缝隙用骨替代物填充。本研究调查了短茎的力学行为，分别关注短期和长期的应变屏蔽和骨重塑。将结果与整体几何形状相同的固体对应物的结果进行比较。使用基于计算机断层扫描（CT）的完整股骨和重建股骨的三维有限元模型。求解了正常行走和爬楼梯两种静态加载情况下的模型。在两根茎的所有格伦区均观察到应变屏蔽；然而，多孔茎的影响程度要小得多（平均约44%）。随后的骨吸收也被预测为低得多的程度（平均约42%）。此外，多孔骨柄尖端周围骨的应变浓度不如实心骨柄突出，表明大腿疼痛的风险较低。多孔短阀杆设计在短期和长期内都有很好的效果。

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引用次数: 0

A comprehensive review on the printing efficiency, precision, and cell viability in 3D bioprinting 对3D生物打印的打印效率、精度和细胞活力进行了全面的综述

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-09-29 DOI: 10.1016/j.medengphy.2025.104448

Bowen Li , Zhen Wang , Chuanzhen Huang , Longhua Xu , Shuiquan Huang , Meina Qu , Zhengkai Xu , Dijia Zhang , Baosu Guo , Tianye Jin , Chunhui Ji

Three-dimensional (3D) bioprinting demonstrates significant potential for advancing regenerative medicine through precise fabrication of functional tissue constructs via controlled deposition of cells, biomaterials, and bioactive factors. However, balancing key parameters-printing efficiency, resolution, and cell viability-remains challenging for replicating native tissue complexity. This review comprehensively examines recent advancements in three prominent bioprinting modalities: inkjet, extrusion-based, and digital light processing (DLP). Analysis reveals inherent performance trade-offs among these technologies. Inkjet bioprinting achieves high resolution (10-80 μm) at moderate speeds but exhibits limited cell viability (74-85%). Extrusion-based methods enable higher fabrication rates (0.00785-62.83 mm³/s) with variable viability (40-90%) at reduced resolution (100-2000 μm). DLP offers superior efficiency (0.648-840 mm³/s) and ultra-high resolution (2-50 μm) with favorable viability (75-95%), although limitations persist regarding photoinitiator toxicity and light penetration depth. Critical examination identifies energy-induced cell damage as a significant factor, with shear stress and UV exposure representing key detrimental influences. Bioink properties also emerge as crucial determinants of printing outcomes. The review further integrates modeling approaches for extrusion-based bioprinting and discusses preliminary computational modeling attempts. Future directions should focus on developing low-viscosity cell-compatible bioinks, advancing hybrid printing strategies, and establishing predictive models to harmonize printing parameters with biological outcomes. Interdisciplinary collaboration remains essential to fully realize the clinical potential of bioprinted tissues and organoids.

三维（3D）生物打印通过控制细胞、生物材料和生物活性因子的沉积来精确制造功能组织结构，展示了推进再生医学的巨大潜力。然而，平衡关键参数——打印效率、分辨率和细胞活力——仍然是复制天然组织复杂性的挑战。本文综述了三种突出的生物打印方式的最新进展：喷墨、挤压和数字光处理（DLP）。分析揭示了这些技术之间固有的性能权衡。在中等速度下，喷墨生物打印可以获得高分辨率（10-80 μm），但细胞存活率有限（74-85%）。基于挤压的方法可以在降低分辨率（100-2000 μm）下实现更高的制造速率（0.00785-62.83 mm³/s）和可变生存能力（40-90%）。DLP具有卓越的效率（0.648-840 mm³/s）和超高分辨率（2-50 μm），具有良好的生存能力（75-95%），但在光引发剂毒性和光穿透深度方面仍存在局限性。关键检查确定能量诱导的细胞损伤是一个重要因素，剪切应力和紫外线暴露是主要的有害影响。生物墨水的特性也成为打印效果的关键决定因素。这篇综述进一步整合了基于挤压的生物打印的建模方法，并讨论了初步的计算建模尝试。未来的方向应该集中在开发低粘度细胞兼容的生物墨水，推进混合打印策略，建立预测模型以协调打印参数与生物结果。跨学科合作对于充分发挥生物打印组织和类器官的临床潜力至关重要。

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引用次数: 0

A user-defined element for simulating hydrogel injection into trabecular bone: Numerical simulations and experimental validation 一个用户定义的元素模拟水凝胶注射到小梁骨：数值模拟和实验验证

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.medengphy.2025.104411

Georgios F. Samaras , Vincent Dischl , Anita Fung , Vincent A. Stadelmann , Ulrike Kettenberger , Stephen J. Ferguson , Benedikt Helgason

In this study, we present a comprehensive numerical model to simulate the injection of hydrogel into femurs. The model is designed to capture the complex interactions between the hydrogel rheological properties and the biomechanical environment of the femur. The coupled mechanical-flow formulation, based on the Theory of Porous Media, is implemented in an open source Abaqus UEL subroutine, where displacements, pressure and saturation are the unknowns. The rheological properties of the hydrogel were calibrated against experimental augmentations in three femurs and the calibrated model was then applied to three different femurs where the hydrogel patterns were compared to experimental data. Furthermore, the simulations demonstrated the effect of injection flow rate and heterogeneous permeability on the hydrogel patterns and quantified the trabecular matrix's solid strains developed during the injection process. The simulations captured well the volume distribution with an average dice coefficient of 0.75 for the three tested specimens. In addition, the calculated solid strains were below the tensile yield limit for the tested flow rate range. A description of the constitutive equations and the implementation into an Abaqus user element subroutine is provided. Overall, our modeling methodology provides a computational tool that can be used to more accurately model bone augmentation and furthermore plan more safely the treatment of osteoporotic patients.

在这项研究中，我们提出了一个综合的数值模型来模拟水凝胶注入股骨。该模型旨在捕捉水凝胶流变特性与股骨生物力学环境之间复杂的相互作用。基于多孔介质理论的耦合力学-流动公式在开源的Abaqus UEL子程序中实现，其中排量、压力和饱和度是未知的。根据三个股骨的实验增强对水凝胶的流变特性进行校准，然后将校准模型应用于三个不同的股骨，并将水凝胶模式与实验数据进行比较。此外，模拟显示了注入流量和非均质渗透率对水凝胶形态的影响，并量化了注入过程中小梁基质的固体应变。模拟结果较好地反映了三种试样的体积分布，平均骰子系数为0.75。此外，计算出的固体应变低于测试流速范围内的拉伸屈服极限。给出了本构方程的描述及其在Abaqus用户元素子程序中的实现。总的来说，我们的建模方法提供了一种计算工具，可以用来更准确地模拟骨增强，并进一步计划更安全的骨质疏松症患者的治疗。

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引用次数: 0

An adaptive bin-stream network based on frequency decomposition for classifying atrial fibrillation with low SNR data 基于频率分解的自适应双流网络在低信噪比房颤分类中的应用

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-07 DOI: 10.1016/j.medengphy.2025.104412

Jilin Wang , Tengqun Shen , Mengfan Li , Yijun Ma , Guozhen Sun , Yatao Zhang

To detect atrial fibrillation (AF) in ECG signals with low signal-to-noise ratio (SNR), this study introduces the adaptive bin-stream network (ABNet) based on frequency decomposition. The ABNet offers notable advantages: it exhibits high robustness in identifying AF amidst noisy environments, it decomposes the ECG signals into 32-frequency channel recordings to refine frequency ranges for better identifying AF, and it designs an adaptive bin-stream network to gain the optimal results. The method utilizes a 5-level Haar wavelet packet decomposition to decompose the preprocessed ECG signals into their corresponding 32-frequency channel recordings, and the preprocessing signals and the recordings are fed into waveform stream and frequency stream of the bin-stream network, respectively. Finally, an adaptive approach is employed to obtain the optimal classification results. The ABNet was validated for the PhysioNet/Computing in Cardiology Challenge 2017 database (CinC 2017 Db) to classify 4 categories i.e., normal sinus rhythm (N), AF, other abnormal rhythms (O) and noise (P), and it achieved accuracy (acc) 93.08 %, precision (ppv) 78.68 %, sensitivity (sen) 81.84 %, specificity (spec) 94.00 %, and F₁ 0.8382. In addition, it achieved the acc 97.98, ppv 96.40, sen 98.37 %, spec 98.41 %, and F₁ 0.9595 for a synthetic Db consisting of Shandong provincial hospital AF database (SPH AF Db) and CinC 2011 Db for classifying 3 categories i.e., N, AF and P. These results underscore the effectiveness of the ABNet in capturing detailed information about waveform and different frequencies in ECG signals.

为了在低信噪比的心电信号中检测房颤，本研究引入了基于频率分解的自适应帧流网络（ABNet）。ABNet具有显著的优势：它在嘈杂环境中识别AF方面具有很高的鲁棒性，它将心电信号分解为32个频率通道记录以优化频率范围以更好地识别AF，并设计了自适应bin-stream网络以获得最佳结果。该方法利用5级Haar小波包分解将预处理后的心电信号分解为相应的32频通道记录，将预处理后的信号和记录分别送入bin-stream网络的波形流和频率流。最后，采用自适应方法获得最优分类结果。在PhysioNet/Computing in Cardiology Challenge 2017数据库（CinC 2017 Db）中对ABNet进行了验证，对正常窦性心律(N)、AF、其他异常心律(O)和噪声(P) 4类进行了分类，准确率（acc）为93.08%，精密度（ppv）为78.68%，灵敏度（sen）为81.84%，特异性（spec）为94.00%，F1为0.8382。此外，由山东省医院房颤数据库（SPH AF Db）和CinC 2011 Db组成的合成Db对N、AF和p 3个类别进行分类，其准确度为97.98，ppv为96.40，sen为98.37%，spec为98.41%，F1为0.9595，这些结果表明ABNet在捕获心电信号中波形和不同频率的详细信息方面是有效的。

{"title":"An adaptive bin-stream network based on frequency decomposition for classifying atrial fibrillation with low SNR data","authors":"Jilin Wang , Tengqun Shen , Mengfan Li , Yijun Ma , Guozhen Sun , Yatao Zhang","doi":"10.1016/j.medengphy.2025.104412","DOIUrl":"10.1016/j.medengphy.2025.104412","url":null,"abstract":"<div><div>To detect atrial fibrillation (AF) in ECG signals with low signal-to-noise ratio (SNR), this study introduces the adaptive bin-stream network (ABNet) based on frequency decomposition. The ABNet offers notable advantages: it exhibits high robustness in identifying AF amidst noisy environments, it decomposes the ECG signals into 32-frequency channel recordings to refine frequency ranges for better identifying AF, and it designs an adaptive bin-stream network to gain the optimal results. The method utilizes a 5-level Haar wavelet packet decomposition to decompose the preprocessed ECG signals into their corresponding 32-frequency channel recordings, and the preprocessing signals and the recordings are fed into waveform stream and frequency stream of the bin-stream network, respectively. Finally, an adaptive approach is employed to obtain the optimal classification results. The ABNet was validated for the PhysioNet/Computing in Cardiology Challenge 2017 database (CinC 2017 Db) to classify 4 categories i.e., normal sinus rhythm (N), AF, other abnormal rhythms (O) and noise (P), and it achieved accuracy (<em>acc</em>) 93.08 %, precision (<em>ppv</em>) 78.68 %, sensitivity (<em>sen</em>) 81.84 %, specificity (<em>spec</em>) 94.00 %, and <em>F</em><sub>1</sub> 0.8382. In addition, it achieved the <em>acc</em> 97.98, <em>ppv</em> 96.40, <em>sen</em> 98.37 %, <em>spec</em> 98.41 %, and <em>F</em><sub>1</sub> 0.9595 for a synthetic Db consisting of Shandong provincial hospital AF database (SPH AF Db) and CinC 2011 Db for classifying 3 categories i.e., N, AF and P. These results underscore the effectiveness of the ABNet in capturing detailed information about waveform and different frequencies in ECG signals.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"145 ","pages":"Article 104412"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of non-invasive P2/P1 ratio and time to peak at rest and during isometric handgrip stress 无创P2/P1比值的重测信度以及静止和等距握力时的峰值时间

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-25 DOI: 10.1016/j.medengphy.2025.104421

Alinne A. Oliveira, Mansueto Gomes-Neto, Alanne Oliveira, Filipe Malta, Gabriel Novaes, Vitor Oliveira Carvalho, Rafael Pereira

Purpose

This study aimed to determine the test-retest reliability of the non-invasive P2/P1 ratio, a metric derived from cranial pulsatility waveforms, in healthy young adults under both resting and physiological stress conditions.

Methods

Intracranial pulsatility waveforms were acquired from 58 healthy young adults (mean age 23.4 ± 4.0 years). The protocol involved a 5-minute baseline, 1 min of maximal isometric handgrip effort, and a 5-minute recovery period. This procedure was repeated on three separate days. Relative reliability was evaluated using the Intraclass Correlation Coefficient (ICC), and absolute reliability was assessed with the Standard Error of Measurement (SEM) and the Minimum Detectable Change (MDC).

Results

The P2/P1 ratio demonstrated good test-retest reliability across all conditions: baseline (ICC = 0.72), during maximal isometric effort (ICC = 0.74), and recovery (ICC = 0.72). Absolute reliability was high, with a small Standard Error of Measurement (SEM ≤ 0.1) and a Minimum Detectable Change (MDC95) of approximately 0.24 established during the effort.

Conclusion

The non-invasively measured P2/P1 ratio is a reliable metric in healthy young adults, maintaining its consistency even during significant cardiovascular stress. This study also establishes the MDC, providing a quantitative threshold to distinguish true physiological changes from measurement error. These findings support the use of the P2/P1 ratio for monitoring cerebrovascular dynamics and provide foundational data for future studies in clinical populations, such as critically ill patients.

目的：本研究旨在确定健康年轻人在静息和生理应激条件下无创P2/P1比值的测试-重测可靠性。方法对58例健康青年（平均年龄23.4±4.0岁）进行颅内脉搏波形分析。该方案包括5分钟的基线，1分钟的最大等长握力和5分钟的恢复期。这一过程分别在三天内重复进行。相对信度采用类内相关系数（ICC）评估，绝对信度采用计量标准误差（SEM）和最小可检测变化（MDC）评估。结果P2/P1比值在基线（ICC = 0.72）、最大等距努力（ICC = 0.74）和恢复（ICC = 0.72）等条件下均表现出良好的重测信度。绝对可靠性很高，测量标准误差很小（SEM≤0.1），最小可检测变化（MDC95）约为0.24。结论无创测量的P2/P1比值在健康年轻人中是一个可靠的指标，即使在严重的心血管压力下也能保持其一致性。本研究还建立了MDC，提供了一个定量阈值来区分真实的生理变化和测量误差。这些发现支持使用P2/P1比值监测脑血管动力学，并为未来临床人群（如危重患者）的研究提供基础数据。

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引用次数: 0

Synergistic dual-nanostructure antibacterial-antifouling coating for tracheostomy tubes to reduce ventilator-associated pneumonia 用于气管造口管的协同双纳米结构抗菌防污涂层，以减少呼吸机相关性肺炎

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI: 10.1016/j.medengphy.2025.104416

Jie Gong , Linsai Guan , Feiyao Wang , Muhammad Fayyaz ur Rehman , Jianping Zhu

Objective

To develop a dual-nanostructure coating for tracheostomy tubes to prevent ventilator-associated pneumonia (VAP) by inhibiting bacterial biofilm formation through combined superhydrophobic antifouling and sustained silver ion (Ag⁺) release.

Methods

Mesoporous silica nanoparticles (MSNs) were functionalized with octyltriethoxysilane (OTES) for superhydrophobicity (water contact angle: 162.8 ± 1°, sliding angle: 3.1 ± 0.5°) and loaded with 5–10 nm Ag₂O nanoparticles. Stability was evaluated via sandpaper abrasion tests (15 cycles, 120 g load) and short-term immersion (24 h) in pH 2–13 solutions. In vitro evaluations included quantification of bacterial adhesion (P. aeruginosa, Escherichia coli, S. aureus; 1 × 10⁸ CFU/mL), biofilm analysis by SEM/CLSM, and CCK-8 cytotoxicity assays with NIH/3T3 fibroblasts. In vivo, an 8-pig VAP model with hourly P. aeruginosa inoculation (1 × 10⁶ CFU/mL) was used to assess tracheal biofilm thickness, lung bacterial load, and inflammatory infiltration via H&E staining.

Results

The coating retained superhydrophobicity after challenges, reduced bacterial adhesion by ≥90.2 % vs. uncoated controls in vitro with disrupted biofilms and >95 % cell viability. In pigs, it reduced tracheal biofilm thickness by 65 % (p < 0.05), lung bacterial load by 82 % (p < 0.01), and neutrophil infiltration (p < 0.05).

Conclusion

The Ag₂O-MSNs@OTES coating effectively combats VAP via synergistic effects, with favorable short-term stability, excellent biocompatibility, and low cost (<$5/tube), supporting its potential for clinical translation. Further long-term stability tests are required to validate performance over extended clinical use.

目的研制一种用于气管造口管的双纳米结构涂层，通过超疏水防污和银离子（Ag +）的持续释放抑制细菌生物膜的形成，预防呼吸机相关性肺炎（VAP）。方法采用辛基三乙基氧基硅烷（OTES）对多孔二氧化硅纳米颗粒（MSNs）进行超疏水性修饰（水接触角为162.8±1°，滑动角为3.1±0.5°），并负载5 ~ 10 nm Ag₂O纳米颗粒。通过砂纸磨损试验（15次循环，120 g负荷）和在pH 2-13溶液中短期浸泡（24 h）来评估稳定性。体外评价包括定量细菌粘附（铜绿假单胞菌、大肠杆菌、金黄色葡萄球菌；1 × 10⁸CFU/mL），扫描电镜/CLSM生物膜分析，以及NIH/3T3成纤维细胞CCK-8细胞毒性测定。在体内，采用每小时接种1 × 10 26 CFU/mL铜绿假单胞菌（P. aeruginosa）的8头猪VAP模型，通过H&；E染色评估气管生物膜厚度、肺部细菌负荷和炎症浸润。结果在生物膜被破坏的情况下，与未包被的对照组相比，包被在体外保持了超疏水性，细菌粘附率降低了≥90.2%，细胞活力降低了95%。在猪中，它使气管生物膜厚度减少65% (p < 0.05)，肺细菌负荷减少82% (p < 0.01)，中性粒细胞浸润减少（p < 0.05）。结论Ag₂O-MSNs@OTES涂层通过协同作用有效对抗VAP，具有较好的短期稳定性、良好的生物相容性和较低的成本（5美元/支），具有临床转化潜力。需要进一步的长期稳定性测试来验证延长临床使用的性能。

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引用次数: 0

Long-term performance of a low-modulus acrylic cement in a simulated physiological environment 低模量丙烯酸水泥在模拟生理环境下的长期性能研究

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-09-29 DOI: 10.1016/j.medengphy.2025.104447

C. Lardilleux , C. Lavergne , F. Marcq , M. Faruch , C. Lacabanne , E. Dantras

A vertebroplasty bone cement, designed to exhibit mechanical properties closer to those of the vertebral bone, was investigated. Indeed, adjacent fractures are attributed to an excessive difference in elastic modulus between the vertebrae and the bone cement implying another operation to repair the newly damaged vertebra. The proposed solution to lower the mechanical properties is the introduction of gelatine in the powder of the cement. This low modulus bone cement was studied by quasi-static compression, dynamic mechanical analysis and fatigue tests. Compression testing showed a significant decrease of the elastic modulus of 33 % after 6 months of immersion in a PBS solution at 37 °C, confirmed by the dynamic mechanical analysis. This analysis also showed that immersion and the introduction of gelatine in the cement influence the relaxations of the PMMA matrix. Fatigue performance was also studied with and without gelatine and showed that it presents a characteristic life of at least 24,600 cycles for a load of 7 MPa. While compression testing indicates a reduction in mechanical performance, all others tests demonstrated that gelatine does not significantly impair the overall properties of acrylic bone cement that still possess sufficient properties to achieve its main goal to stabilise damaged vertebrae.

研究了一种椎体成形术骨水泥，旨在展示更接近椎体骨的机械性能。事实上，相邻骨折是由于椎骨和骨水泥之间的弹性模量差异过大，这意味着需要再次手术修复新损伤的椎骨。提出的降低水泥力学性能的方法是在水泥粉中加入明胶。通过准静态压缩、动态力学分析和疲劳试验对该低模数骨水泥进行了研究。压缩测试表明，在37°C的PBS溶液中浸泡6个月后，弹性模量显著降低33%，这一点得到了动态力学分析的证实。该分析还表明，水泥中的浸没和明胶的引入都会影响PMMA基体的弛豫。还研究了加明胶和不加明胶的疲劳性能，结果表明，在7 MPa的载荷下，它的特征寿命至少为24,600次。虽然压缩测试表明机械性能下降，但所有其他测试都表明明胶不会显著损害丙烯酸骨水泥的整体性能，仍然具有足够的性能来实现其稳定受损椎骨的主要目标。

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引用次数: 0

Hybrid artificial intelligence approaches and bioimpedance spectroscopy for classifying pancreatic disease 混合人工智能方法和生物阻抗光谱用于胰腺疾病分类

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-08-26 DOI: 10.1016/j.medengphy.2025.104425

Sergey Filist , Riad Taha Al-Kasasbeh , Tigran Gevorkyan , Osama M.Al- Habahbeh , Olga Vladimirovna Shatalova , Nikolay A. Korenevskiy , Maksim Ilyash , Evgeny Starkov , Ashraf Shaqadan , Ahmad Telfah

This research develops bioimpedance spectroscopy methods aimed at improving the differential diagnosis of pancreatic diseases. A novel approach for forming descriptors from bioimpedance data is introduced, which involves analyzing four amplitude-phase-frequency characteristics obtained from quasi-orthogonal leads. This method establishes informative feature spaces utilized by a hybrid classifier specifically designed to differentiate between pancreatitis and pancreatic cancer. The hybrid classifier comprises five macro layers, integrating probabilistic neural networks and fuzzy logical inference. Comprehensive experimental software studies and clinical tests validate the system's performance, demonstrating diagnostic sensitivity and specificity levels comparable to established techniques. The findings suggest that utilizing multifrequency bioimpedance measurements in neural network classifiers enhances the accuracy of clinical decision-making, potentially leading to better diagnostic outcomes for pancreatic diseases.

本研究发展生物阻抗谱方法，旨在改善胰腺疾病的鉴别诊断。介绍了一种利用生物阻抗数据形成描述子的新方法，该方法涉及分析从准正交引线获得的四个幅相频率特性。这种方法建立信息特征空间利用的混合分类器专门设计来区分胰腺炎和胰腺癌。混合分类器包括五个宏观层，融合了概率神经网络和模糊逻辑推理。全面的实验软件研究和临床测试验证了该系统的性能，证明了与现有技术相当的诊断敏感性和特异性水平。研究结果表明，在神经网络分类器中使用多频生物阻抗测量可以提高临床决策的准确性，从而可能导致更好的胰腺疾病诊断结果。

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引用次数: 0

Technical note: Exploring acoustic emission characteristics from quasistatic compression testing of aged and fresh bovine cortical bone 技术说明：从准静态压缩测试中探索老化和新鲜牛皮质骨的声发射特性

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-11-01 Epub Date: 2025-09-14 DOI: 10.1016/j.medengphy.2025.104439

McKenna Roan , Nick Hudyma , George G.A. Pujalte , Jeff T. Wight

Bone specimens are preserved using various methods, which have been shown to influence their material properties. An unexplored process of assessing the influence of preservation methods is using acoustic emission (AE) monitoring during quasistatic compression testing. AEs are transient ultrasonic waves generated during abrupt, localized plastic deformation. AE waveforms were collected and assessed for specimens preserved with two methods: fresh frozen and aged by boiling and bleaching. Results demonstrated that aged specimens exhibit different AE characteristics compared to fresh specimens, including an earlier onset of microcracking, higher AE event counts, and greater AE amplitudes and energies. Aged specimens generally showed a mix of tensile and shear microcracks, while fresh specimens predominantly exhibited shear microcracks. This study highlights the influence of preservation methods on the AE characteristics of bone tested in compression, providing valuable insight into the differences in microcracking phenomena between fresh and aged specimens.

保存骨标本的方法多种多样，这些方法会影响其材料特性。在准静态压缩测试中使用声发射（AE）监测是评估保存方法影响的一个尚未开发的过程。ae是在突然的局部塑性变形过程中产生的瞬态超声波。收集并评估了新鲜冷冻和煮沸、漂白两种保存方法的AE波形。结果表明，老化试样表现出不同于新鲜试样的声发射特征，包括微裂纹发生时间更早，声发射事件数更高，声发射振幅和能量更大。时效后的试样主要表现为拉伸微裂纹和剪切微裂纹的混合，而新鲜试样主要表现为剪切微裂纹。本研究强调了保存方法对压缩测试骨声发射特性的影响，为了解新鲜和老化标本之间微开裂现象的差异提供了有价值的见解。

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