Medical Engineering & Physics最新文献_第9页

Four-dimensional flow magnetic resonance imaging assessment of left ventricular hemodynamics in transplanted hearts with good postoperative course 术后良好移植心脏左室血流动力学的四维磁共振成像评价

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-30 DOI: 10.1016/j.medengphy.2025.104373

Tomohiro Otani , Seiko Ide , Yuya Mashitani , Yasushi Sakata , Shigeo Wada

Heart transplantation (HTx) is an established treatment for patients with advanced heart failure, although postoperative rejection responses hamper favorable long-term treatment outcomes. Medical imaging is a non-invasive diagnostic modality that can provide attractive insights into cardiac physiology for HTx, including morphological characteristics and cardiac hemodynamics. This study aimed to achieve a basic understanding of left ventricular (LV) hemodynamics in patients with good treatment outcomes following HTx. Specifically, four-dimensional magnetic resonance imaging was performed on 10 patients with a good postoperative course following HTx and 24 controls without a prior history of heart diseases nor HTx. LV hemodynamics were evaluated from the LV flow kinetic energy. We found that LV volumetric functions and kinetic energy ranges were not significantly different between the HTx and control groups, supporting good efficacy of HTx. Nevertheless, a temporal increase in the kinetic energy in late diastole owing to atrial contraction was present in the control group but absent in the HTx group except for one HTx patient. These findings raise the need of further evaluation of cardiac hemodynamics and the pathophysiology of HTx patients even within normal ranges of volumetric and flow transport functions.

心脏移植（HTx）是晚期心力衰竭患者的既定治疗方法，尽管术后排斥反应阻碍了良好的长期治疗结果。医学成像是一种非侵入性的诊断方式，可以为HTx的心脏生理学提供有吸引力的见解，包括形态学特征和心脏血流动力学。本研究旨在对HTx术后治疗效果良好的患者的左室血流动力学有一个基本的了解。具体而言，对10例HTx术后病程良好的患者和24例没有心脏病史或HTx的对照组进行了四维磁共振成像。从左室血流动能评价左室血流动力学。我们发现HTx与对照组的左心室容积功能和动能范围无显著差异，支持HTx的良好疗效。然而，在对照组中，由于心房收缩导致的舒张后期动能暂时增加，而在HTx组中，除了一名HTx患者外，没有出现这种情况。这些发现提出了进一步评估HTx患者心脏血流动力学和病理生理学的必要性，即使在正常的容量和血流运输功能范围内。

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引用次数: 0

Effects of mechanical stimuli on bone cells for regenerative medicine: A review of recent experimental and computational methods 机械刺激对再生医学中骨细胞的影响：最近实验和计算方法的综述

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-22 DOI: 10.1016/j.medengphy.2025.104369

Emilie Wiedemann-Fodé , Jessica Schiavi-Tritz , Halima Kerdjoudj , Cédric Laurent

Mechanobiology integrates biological and mechanical cues to provide a comprehensive understanding of how physical forces influence tissue regeneration, specifically focusing on bone growth and repair. This review presents a comprehensive overview of the latest developments in bone mechanobiology and highlights the remaining scientific and methodological challenges. Following a brief presentation of the challenges facing cell therapy, and in particular the application of different types of mechanical stimuli, the article examines these various processes on cells and tissues such as compressors and bioreactors operating at low frequencies (in the Hz range). Special attention is given to cutting-edge ultrasound techniques, such as the LIPUS method with MHz frequencies and low intensities ranging from 0.5 to 100 mW/cm², and with an emphasis on the emerging application of acoustic levitation with frequencies ranging from 340 kHz to 2.12 MHz permitting non-invasive manipulation of cells and tissues in biological research, with initial beneficial results in cell therapy. Lastly, the review offers a detailed analysis of multi-scale and multi-physics in silico approaches that may contribute to interpret the obtained experimental results. Agent-based models capture the discrete behaviour of individual cells, while continuum models describe tissue mechanics though averaged properties, offering complementary approaches to study complex mechanobiological phenomena. Such approaches hold the potential to drive transformative advances in bone regeneration medicine, providing a roadmap for future research.

机械生物学整合了生物和机械线索，提供了物理力量如何影响组织再生的全面理解，特别是关注骨骼生长和修复。本文综述了骨力学生物学的最新发展，并强调了在科学和方法上的挑战。在简要介绍细胞疗法面临的挑战，特别是不同类型的机械刺激的应用之后，文章检查了细胞和组织上的这些不同过程，例如在低频（Hz范围内）操作的压缩机和生物反应器。特别关注尖端超声技术，如LIPUS方法，频率为MHz，低强度范围为0.5至100 mW/cm²，并强调频率为340 kHz至2.12 MHz的声悬浮的新兴应用，允许在生物研究中对细胞和组织进行非侵入性操作，并在细胞治疗中取得初步有益结果。最后，本文详细分析了可能有助于解释实验结果的多尺度和多物理场的计算机方法。基于主体的模型捕捉单个细胞的离散行为，而连续体模型通过平均特性描述组织力学，为研究复杂的力学生物学现象提供了补充方法。这些方法具有推动骨再生医学变革的潜力，为未来的研究提供了路线图。

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引用次数: 0

The influence of boiling bubble on the acoustic field and bubble dynamics in histotripsy: A numerical investigation 沸腾气泡对声场及气泡动力学的影响：数值研究

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-22 DOI: 10.1016/j.medengphy.2025.104367

Ting Li , Yufeng Zhou

Boiling histotripsy (BH) is a non-invasive treatment technique that leverages cavitation effects to disintegrate soft tissue. However, the influence of boiling bubble on the acoustic field and bubble dynamics, which are key mechanisms underlying tissue destruction in BH, is not yet fully understood. This study aims to elucidate the acoustic field distribution and dynamics of a single bubble, demonstrate the generation of intrinsic cavitation bubbles, and predict the associated cavitation damage using a numerical model. The Westervelt equation was employed to simulate the nonlinear propagation of ultrasound pulses in biological tissues, considering varying boiling bubble sizes at the focus and initial acoustic pressures on the transducer surface. Moreover, the Keller-Miksis equation model, combined with the Voigt model, was used to simulate the nonlinear oscillation of bubbles. The presence of a boiling bubble results in significant acoustic reflection at the bubble interface, particularly a notably strong negative pressure. Simulation results show that intrinsic cavitation occurs in a bubble radius of 0.4 mm at an initial acoustic pressure of 2 MPa. Increasing the boiling bubble radius to 1.1 mm leads to the extension of cavitation bubbles toward the second layer of the standing wave field. Additionally, the initial acoustic pressure seems to influence intrinsic cavitation more significantly than the boiling bubble radius. Bubble dynamics, including its maximum bubble radii and expansion duration, is significantly affected by the rarefactional wave. This effect is attributed not only to the peak negative pressure but also to the waveform. In conclusion, the presence of a boiling bubble at the focus substantially modifies the acoustic field distribution, the formation of intrinsic cavitation clouds, and the characteristics of bubble dynamics. The boiling bubble radius and the initial acoustic pressure on the transducer surface are critical factors in modifying cavitation-associated tissue fractionation. Appropriate parameter settings for ultrasonic pulses may enhance the efficacy and reduce the potential complications in BH treatment.

煮沸组织术（煮沸组织术）是一种利用空化效应分解软组织的非侵入性治疗技术。然而，沸点气泡对声场和气泡动力学的影响是BH中组织破坏的关键机制，目前还没有完全了解。本研究旨在阐明单个气泡的声场分布和动力学，展示固有空化气泡的产生，并利用数值模型预测相关的空化损伤。考虑焦点处沸腾气泡大小和换能器表面初始声压的变化，采用Westervelt方程模拟超声脉冲在生物组织中的非线性传播。此外，采用Keller-Miksis方程模型结合Voigt模型对气泡的非线性振荡进行了模拟。沸腾气泡的存在导致气泡界面产生明显的声反射，特别是明显的强负压。仿真结果表明，在初始声压为2 MPa的条件下，气泡半径为0.4 mm处出现本征空化现象。当沸腾泡半径增大到1.1 mm时，空化泡向驻波场第二层扩展。此外，初始声压似乎比沸腾气泡半径对固有空化的影响更显著。气泡动力学，包括气泡的最大半径和膨胀持续时间，受反射波的显著影响。这种影响不仅归因于峰值负压，也归因于波形。综上所述，焦点处沸腾气泡的存在极大地改变了声场分布、本征空化云的形成以及气泡动力学特征。沸腾气泡半径和传感器表面的初始声压是改变空化相关组织分馏的关键因素。适当的超声脉冲参数设置可以提高治疗BH的疗效，减少潜在的并发症。

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引用次数: 0

Novel fusion-based time-frequency analysis for early prediction of sudden cardiac death from electrocardiogram signals 基于心电图信号的新型融合时频分析用于心脏性猝死的早期预测

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-20 DOI: 10.1016/j.medengphy.2025.104370

Shaik Karimulla, Dipti Patra

Sudden cardiac death (SCD) is one of the leading causes of global mortality, often occurring without warning and driven by complex cardiac dynamics. Despite significant advances in cardiovascular diagnostics, accurately predicting SCD at an early stage remains a critical challenge. This study proposes a novel fusion-based time-frequency (T-F) deep learning framework for the early prediction of SCD by classifying associated cardiac conditions. Electrocardiogram (ECG) signals were first denoised and segmented to isolate clinically relevant patterns. These signals were then transformed into two-dimensional T-F representations using spectrograms and scalograms, capturing complementary temporal and spectral information. An average fusion technique merged these representations, enriching T-F images with enhanced discriminatory power. The fused images were used to train deep learning (DL) models, and performance was evaluated using subject-wise data splits to assess generalizability across individuals. The proposed approach achieved a classification accuracy of 94.60 %, effectively identifying cardiac conditions associated with SCD one hour before its onset. This fusion-based framework shows strong potential for integration into real-time, automated diagnostic systems, enabling early warning, personalized monitoring, and timely intervention to reduce fatal outcomes.

心源性猝死（SCD）是全球死亡的主要原因之一，通常在没有预警的情况下发生，并由复杂的心脏动力学驱动。尽管心血管诊断取得了重大进展，但在早期阶段准确预测SCD仍然是一项重大挑战。本研究提出了一种新的基于融合的时间-频率（T-F）深度学习框架，通过分类相关的心脏疾病来早期预测SCD。首先对心电图信号进行去噪和分割，以分离出临床相关的模式。然后利用谱图和尺度图将这些信号转换成二维T-F表示，捕获互补的时间和光谱信息。一种平均融合技术融合了这些表征，增强了T-F图像的鉴别能力。融合的图像用于训练深度学习（DL）模型，并使用主题数据分割来评估性能，以评估个体之间的通用性。该方法实现了94.60%的分类准确率，有效地在SCD发病前一小时识别出与之相关的心脏状况。这种基于融合的框架显示出强大的潜力，可以集成到实时、自动化的诊断系统中，实现早期预警、个性化监测和及时干预，以减少致命后果。

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引用次数: 0

Whole-cycle and time-specific validation of a GUI-based ground reaction force estimation tool for clinical gait analysis without a force plate 基于gui的地面反作用力估计工具的全周期和时间特异性验证，用于临床步态分析，无需力板

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-20 DOI: 10.1016/j.medengphy.2025.104366

Pegah Jamali , Li-Shan Chou , Robert D. Catena

Relying on patients to make clean contacts with multiple force plates during clinical gait analysis can be time-consuming and dissuade clinicians from collecting biomechanical data. Several methods have been proposed to estimate ground reaction forces (GRFs) without force plates, though many can be computationally intensive. As an alternative to measuring GRFs, we evaluated the whole cycle and time frame accuracy of a built-in, GUI-based GRF estimation tool.

Twenty-seven healthy adult participants walked over two consecutive force plates. We evaluated the accuracy of estimated GRFs against force plates as the gold standard using correlation, residual error analysis, and statistical parametric mapping (SPM).

Estimated GRF magnitudes were accurate in the anterior-posterior (R²=0.86, %RMSE=7.28), and vertical directions (R²=0.86, %RMSE=6.09), but not in the medio-lateral direction (R²=0.30, %RMSE=12.46). SPM revealed errors in the sagittal plane in mid- and late-stance, with no specific errors in the medio-lateral direction.

Estimated centers of pressure (CoPs) showed good accuracy (R²≥0.99, %RMSE≤4.46). However, SPM showed estimated CoPs were consistently anterior to the true CoPs.

Sagittal GRFs are predicted with good accuracy, showing whole cycle errors comparable to more complex methods, while also displaying little early stance error and offering user-friendly implementation.

在临床步态分析中，依靠患者与多个力板进行清洁接触可能会耗费时间，并且会阻碍临床医生收集生物力学数据。已经提出了几种方法来估计地面反作用力（GRFs）没有力板，虽然许多可以计算密集。作为测量GRF的替代方法，我们评估了内置的基于gui的GRF估计工具的整个周期和时间框架精度。27名健康的成年参与者连续走过两个测力板。我们使用相关性、残差分析和统计参数映射（SPM）来评估估计GRFs对力板的准确性。估计的GRF大小在前后方向（R2=0.86, %RMSE=7.28）和垂直方向（R2=0.86, %RMSE=6.09）准确，但在中外侧方向（R2=0.30, %RMSE=12.46）不准确。SPM显示中位和晚位矢状面错误，中外侧方向无特异性错误。估计压力中心（cop）具有良好的准确性（R2≥0.99,%RMSE≤4.46）。然而，SPM显示估计的cop始终在真实cop的前面。矢状面GRFs的预测精度很高，显示了与更复杂的方法相当的整个周期误差，同时也显示了很少的早期姿态误差，并提供了用户友好的实现。

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引用次数: 0

Development of a biofidelic human spine model for vibration characterization 用于振动表征的仿生人体脊柱模型的开发

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-20 DOI: 10.1016/j.medengphy.2025.104368

Shivam Verma , Arnab Banerjee , Arnab Chanda

Vibration is a physical phenomenon that occurs when objects or systems move back and forth rapidly. Millions of people worldwide are affected by vibration-related health issues every year. However, prolonged exposure to vibration can have serious health implications, including back pain, muscle strain, and damage to nerves and blood vessels. While computational modelling studies and tests on dummies have been performed, these do not accurately simulate the structural and material components of the spine, leading to less accurate results. Therefore, this study attempted to develop a biofidelic spine model using 3D printing technology and based on the THUMS Dummy model (AM50 V 4.02 Pedestrian) that closely simulates a real human spine structure. This developed model was used to perform the experiment exposed to vertical sinusoidal vibrations under different magnitudes (1.1 m/s², 0.75 m/s², and 0.4 m/s²) in the frequency range of 1–20 Hz. The collected data sets were analyzed to study the effect of vertical sinusoidal vibration magnitude and obtain the L₅ to C₁ transmissibility curves across a specified frequency range. The transmissibility curve was further analyzed to appraise the biofidelity of the developed human spine model and compare it to the literature. The results depicted that the two resonance peaks were observed between 2 and 3.5 Hz and 4–6 Hz at magnitude 1.1 m/s² and 0.75 m/s², respectively, and the multiple resonance peaks were observed at the magnitude of 0.4 m/s². The comparison between experimental data sets and biofidelic model responses indicates that the developed model is feasible for simulating vertical sinusoidal vibration-based effects on the human spine.

振动是物体或系统快速来回移动时发生的一种物理现象。全世界每年有数百万人受到与振动有关的健康问题的影响。然而，长时间暴露在振动中会对健康产生严重影响，包括背部疼痛、肌肉拉伤、神经和血管损伤。虽然已经对假人进行了计算建模研究和测试，但这些研究并不能准确地模拟脊柱的结构和材料成分，导致结果不太准确。因此，本研究试图利用3D打印技术，在THUMS假人模型（AM50 V 4.02 Pedestrian）的基础上，开发一个仿生脊柱模型，该模型紧密模拟了真实的人体脊柱结构。利用该模型进行了1 ~ 20 Hz频率范围内不同震级（1.1 m/s2、0.75 m/s2和0.4 m/s2）的垂直正弦振动实验。对收集到的数据集进行分析，研究垂直正弦振动幅值的影响，得到在特定频率范围内的L5到C1传递率曲线。进一步分析传递率曲线，评价建立的人体脊柱模型的生物保真度，并与文献进行比较。结果表明，在震级为1.1 m/s2和0.75 m/s2时，在2 ~ 3.5 Hz和4 ~ 6 Hz范围内分别观测到两个共振峰，在震级为0.4 m/s2时观测到多个共振峰。实验数据集与生物场模型响应的比较表明，所建立的模型可以模拟基于垂直正弦振动的人体脊柱效应。

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引用次数: 0

Letter to the editor in response to: Biomechanical evaluation for bone arthrosis morphology based on reconstructed dynamic kinesiology 致编辑的回复信：基于重建动态运动学的骨关节形态生物力学评价

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-19 DOI: 10.1016/j.medengphy.2025.104365

Triwiyanto Triwiyanto , Sari Luthfiyah , I Putu Alit Pawana , Achmad Rizal

引用次数: 0

On the use of inertial measurement units and musculoskeletal modeling in the calculation of muscle and joint loading at the shoulder 在肩部肌肉和关节载荷计算中使用惯性测量单元和肌肉骨骼建模

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-17 DOI: 10.1016/j.medengphy.2025.104342

Zhou Fang, Damith Senanayake, David C. Ackland

Inertial measurement units (IMUs) are wearable motion sensing devices that support low-cost human kinematics measurement outside of the laboratory; however, the impact of IMU motion measurement errors on estimates of upper limb muscle and joint force using musculoskeletal modeling remains poorly understood. The aims of this study were to measure upper limb kinematics using IMUs and optical motion analysis, and evaluate the differences in shoulder musculoskeletal model estimates of muscle and joint forces when using IMU-based motion analysis and optical motion analysis data. Thirty healthy adults performed activities of daily living at fast and slow speeds while upper limb motion measurement was simultaneously acquired using an optical motion analysis system and self-placed IMUs. Kinematics measurement accuracy using IMUs was highest in humerothoracic joint elevation and scapular lateral rotation, and lowest in humerothoracic plane of elevation and humeral axial rotation. Musculoskeletal model calculations of a muscle’s force were most sensitive to IMU motion measurement errors about the degree of freedom primarily actuated by that muscle. For example, subscapularis force calculations were more sensitive to errors in humeral axial rotation than humeral elevation. Consequently, errors in humeral axial rotation motion measurement affected infraspinatus and subscapularis muscle forces, and subsequently, estimates of the compressive component of the glenohumeral joint force. During fast flexion, a mean difference of 4.5 %BW in the compressive joint force was observed when using IMU motion measurement compared to optical motion analysis data (p < 0.001). The findings of this study provide guidance in the use of IMUs for muscle and joint force calculation during activities of daily living.

惯性测量单元（imu）是可穿戴的运动传感设备，支持实验室外的低成本人体运动学测量；然而，IMU运动测量误差对使用肌肉骨骼模型估计上肢肌肉和关节力的影响仍然知之甚少。本研究的目的是使用imu和光学运动分析来测量上肢运动学，并评估使用基于imu的运动分析和光学运动分析数据时肩部肌肉骨骼模型估计肌肉和关节力的差异。30名健康成人以快、慢速度进行日常生活活动，同时使用光学运动分析系统和自放置imu同时获得上肢运动测量。imu的运动学测量精度在肱骨胸关节抬高和肩胛骨外侧旋转时最高，在肱骨胸关节抬高和肱骨轴向旋转时最低。肌肉骨骼模型的肌肉力计算对IMU运动测量误差最敏感，这些误差主要是由该肌肉驱动的自由度。例如，肩胛下肌力计算对肱骨轴向旋转误差比肱骨抬高误差更敏感。因此，肱骨轴向旋转运动测量的误差会影响冈下肌和肩胛下肌的力量，进而影响对肩关节力的压缩分量的估计。在快速屈曲期间，使用IMU运动测量与光学运动分析数据相比，观察到压缩关节力的平均差异为4.5% BW (p <；0.001)。本研究结果为在日常生活活动中使用imu计算肌肉和关节力提供了指导。

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引用次数: 0

Bimetallic nanoprobe strip for the detection of human chorionic gonadotrophin in pregnancy 双金属纳米探针条用于妊娠期人绒毛膜促性腺激素的检测

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-16 DOI: 10.1016/j.medengphy.2025.104354

Maithili Kantak , Pravin Shende

A novel nanotechnology-based approach was developed to enhance the accuracy and reliability of pregnancy detection to address the limitations of conventional kits like PregaNews, First Response, Accu-Clear, EPT (Error Proof Test), etc. which are based on the enzyme-linked immunosorbent assay (ELISA) method. Such conventional methods often suffer from complex procedures, low precision (33 %), cross-reactivity, and false positives. The developed new diagnostic platform employed a lateral flow assay-based gold-silver nanoprobe (GSNPs) system conjugated with 3-mercaptopropionate and monoclonal antibody 2 (mAb2), pre-dispersed on biodegradable Whatman filter paper and coupled with a smartphone-based application for the detection of hCG in pregnancy. The GSNPs with a particle size of 325.1 ± 0.64 nm, exhibited superior catalytic efficiency (0.29 to 0.37 nm) with significant specificity, and reliability in comparison to digital color analysis via RGB (red, green, blue) and HSV (hue, saturation, value) algorithmic model. This nanotechnology-based system demonstrated a wide detection range (0.4–2.4ng/mL) with a low limit of detection (LOD) at 0.79 ng/mL and limit of quantification (LOQ) at 9.67 ng/mL. The detection of pathological urine was consistent with the artificial urine sample at R²=0.9796 and showed linear relationship with saturation value (y = 5.1849x+3.4559). The biodegradable and portable diagnostic strip generates minimal bio-waste and offers eco-friendly disposal. This platform tool-based strip enables sensitive, rapid, user-friendly, and cost-effective detection of hCG compared to conventional pregnancy tests. The integration of bimetallic nanoprobe strip with smartphone technology ensures ease of accessibility, high precision, and environmental sustainability to increase the demand for such reliable and economic diagnostic tool.

针对PregaNews、First Response、Accu-Clear、EPT （Error Proof Test）等基于酶联免疫吸附试验（ELISA）的常规检测试剂盒的局限性，提出了一种基于纳米技术的新方法，以提高妊娠检测的准确性和可靠性。这些传统方法通常存在操作复杂、精度低（33%）、交叉反应性和假阳性等问题。开发的新诊断平台采用基于侧流分析的金-银纳米探针（GSNPs）系统，结合3-巯基丙酸和单克隆抗体2 (mAb2)，预分散在可生物降解的Whatman滤纸上，并结合基于智能手机的应用程序来检测妊娠期hCG。与采用RGB（红、绿、蓝）和HSV（色相、饱和度、值）算法模型的数字颜色分析相比，粒径为325.1±0.64 nm的gsnp具有更高的催化效率（0.29 ~ 0.37 nm）和特异性和可靠性。该体系检测范围广（0.4 ~ 2.4ng/mL），低检出限（LOD）为0.79 ng/mL，定量限（LOQ）为9.67 ng/mL。病理尿液与人工尿液检测结果一致，R2=0.9796，与饱和值呈线性关系（y = 5.1849x+3.4559）。可生物降解和便携式诊断条产生最小的生物废物，并提供环保处理。与传统的妊娠试验相比，该平台基于工具的试纸条可实现敏感、快速、用户友好和经济高效的hCG检测。双金属纳米探针条与智能手机技术的集成确保了易用性、高精度和环境可持续性，从而增加了对这种可靠和经济的诊断工具的需求。

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引用次数: 0

Study on the properties of capsule shell prepared by multi-type HPMC mixed system 多型HPMC混合体系制备胶囊壳的性能研究

IF 1.7 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics

Pub Date : 2025-05-14 DOI: 10.1016/j.medengphy.2025.104362

Jun Wu , Qingyang Meng , Ruihe Zhao , Yingling Zhu , Jianhua Huang , Yuan Zhang , Jingrou Wang , Jun Gong

The objective of this study is to develop a viable formulation strategy aimed at minimizing the gel content in HPMC capsules and avoiding the issue of variable drug release rates in the different media environments attributed to the excessive gel content within the capsules. Through mixing various types of HPMC with different gel temperatures, the formulation facilitates reaching the staged gelation upon the mold as the temperature decreases, which effectively reduces the requisite amount of gelling agent. Consequently, the decrease in gel agent content ensures that the dissolution of the capsule shell is unaffected by the pH of the medium and the type of ions in the medium. This property allows for uniform drug release rates across diverse media, with complete drug release occurring within approximately 20 min. This improved formula not only reduces the gelling agent content in conventional HPMC formulations but also is characterized by the absence of any organic solvents and the simplicity of operation, thus providing a dependable and widely applicable method for the synthesis of HPMC capsules.

本研究的目的是制定一种可行的配方策略，旨在最大限度地减少HPMC胶囊中的凝胶含量，避免因胶囊内凝胶含量过高而导致不同介质环境下药物释放率变化的问题。通过将不同凝胶温度的各类HPMC混合，使配方随着温度的降低，易于在模具上达到阶段性凝胶化，有效地减少了胶凝剂的需用量。因此，凝胶剂含量的减少确保了胶囊壳的溶解不受介质pH值和介质中离子类型的影响。该特性允许在不同介质中均匀释放药物，在大约20分钟内完全释放药物。该改进配方不仅减少了传统HPMC配方中的胶凝剂含量，而且具有不含任何有机溶剂和操作简单的特点，从而为HPMC胶囊的合成提供了一种可靠且广泛适用的方法。

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引用次数: 0