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Fractional calculus integration for improved ECG modeling: A McSharry model expansion 改进心电图建模的分数微积分整合:麦克沙利模型扩展
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-01 DOI: 10.1016/j.medengphy.2024.104237
Abdelghani Takha , Mohamed Lamine Talbi , Philippe Ravier
This study introduces a new method for modeling electrocardiogram (ECG)1 waveforms using Fractional Differential Equations (FDEs). By incorporating fractional calculus into the well-established McSharry model, the proposed approach achieves improved representation and high precision for a wide range of ECG waveforms. The research focuses on the impact of integrating fractional derivatives into Integer Differential Equation (IDE) models, enhancing the fidelity of ECG signal modeling.
To optimize the model's unknown parameters, a combination of the Predictor-Corrector method for solving FDEs and genetic algorithms for optimization is utilized. The effectiveness of the fractional-order model is assessed through distortion metrics, providing a comprehensive evaluation of the modeling quality.
Comparisons show that the fractional-order model outperforms the traditional McSharry IDE model in modeling quality and compression efficiency. It improves modeling quality by 48.40 % in MSE and compression efficiency by 23.18 % when applied on five beat types of MIT/BIH arrhythmia database. The fractional-order model demonstrates enhanced flexibility while preserving essential McSharry model characteristics, with fractional orders (α) ranging from 0.96 to 0.99 across five beat types.
本研究介绍了一种利用分数微分方程(FDE)对心电图(ECG)1 波形进行建模的新方法。通过将分数微积分纳入成熟的 McSharry 模型,所提出的方法改进了对各种心电图波形的表示并提高了精度。为了优化模型的未知参数,研究人员结合使用了用于求解 FDE 的预测器-校正器方法和用于优化的遗传算法。比较表明,分数阶模型在建模质量和压缩效率方面优于传统的 McSharry IDE 模型。在应用于 MIT/BIH 心律失常数据库的五种搏动类型时,该模型的 MSE 提高了 48.40%,压缩效率提高了 23.18%。分数阶模型在保留 McSharry 模型基本特征的同时提高了灵活性,五种搏动类型的分数阶 (α)范围从 0.96 到 0.99 不等。
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引用次数: 0
Development of a closed-loop controller for functional electrical stimulation therapy plus visual feedback balance training for standing balance training 开发用于站立平衡训练的功能性电刺激疗法加视觉反馈平衡训练闭环控制器
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-16 DOI: 10.1016/j.medengphy.2024.104238
Jae W. Lee , Emerson Grabke , Kelvin Chow , Kristin E. Musselman , Kei Masani
Individuals with incomplete spinal cord injury (iSCI) demonstrate impaired upright balance, resulting in increased fall risk. Task-specific visual feedback balance training (VFBT) has previously been shown to improve upright balance. In addition, therapies using functional electrical stimulation (FES) have been shown to improve various motor functions. Combining VFBT with FES therapy (FES+VFBT) may synergistically improve balance control for those with iSCI. Here we developed the FES+VFBT system that delivered physiologically relevant electrical stimulations to soleus (SOL) and tibialis anterior (TA) muscles during VFBT. Ten young able-bodied individuals participated. Kinematic, kinetic, SOL and TA electromyography (EMG) data during quiet standing and limits-of-stability test were used to design the controller for the FES+VFBT system. To evaluate the performance of the designed controller, the controller outputs, which represented stimulation intensities, were compared with the recorded SOL and TA EMG during the four tasks associated with VFBT (i.e., bullseye, hunting, colour-matching, and ellipse tasks). Except for the bullseye task, the designed controller outputs were highly correlated with the recorded EMG, suggesting that the controller could generate electrical stimulations in a physiological manner. We expect that the addition of FES therapy to VFBT could contribute to improving standing balance for individuals with iSCI.
不完全脊髓损伤(iSCI)患者的直立平衡能力受损,导致跌倒风险增加。此前已有研究表明,针对特定任务的视觉反馈平衡训练(VFBT)可改善直立平衡。此外,使用功能性电刺激(FES)的疗法也被证明可以改善各种运动功能。将 VFBT 与功能性电刺激疗法相结合(FES+VFBT)可协同改善 iSCI 患者的平衡控制能力。在此,我们开发了 FES+VFBT 系统,该系统可在 VFBT 过程中向比目鱼肌(SOL)和胫骨前肌(TA)提供与生理相关的电刺激。十名身体健康的年轻人参与了这项研究。他们利用安静站立和极限稳定测试期间的运动学、动力学、比目鱼肌和胫骨前肌肌电图(EMG)数据设计了 FES+VFBT 系统的控制器。为了评估所设计控制器的性能,将控制器输出(代表刺激强度)与四项与 VFBT 相关的任务(即牛眼、狩猎、颜色匹配和椭圆形任务)中记录的 SOL 和 TA 肌电图进行了比较。除牛眼任务外,设计的控制器输出与记录的肌电图高度相关,表明控制器能以生理方式产生电刺激。我们预计,在 VFBT 的基础上增加 FES 治疗,将有助于改善 iSCI 患者的站立平衡能力。
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引用次数: 0
New training simulator for lumbar puncture base on magnetorheological 基于磁流变技术的新型腰椎穿刺培训模拟器
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-16 DOI: 10.1016/j.medengphy.2024.104240
Chunying Zheng , Xin Yang , Fei Gao , Wenbin Zou , Hui Huang , Yuzheng Li , Xiaochun Zheng

In response to the difficulties in accurately reproducing the resistance drop generated by puncturing key tissue layers with a needle and the poor experience in existing simulators, based on the continuous controllability and rapid response of magnetorheological fluid under the influence of a magnetic field, this paper proposes a lumbar puncture training simulator(LPTS) that can accurately simulate the puncture feedback force within tissues such as the skin, subcutaneous fat, and supraspinous ligament throughout the entire process. By using a dual rod structure and reasonably arranging the damping channel gap, the influence of mechanical friction and zero-field damping force on the feedback force during tissue progression is minimized. This paper introduces the acquisition and modeling analysis of raw data, and based on this, the design, simulation, and mechanical testing of the simulator are carried out. Finally, a performance testing platform for the simulator is established to evaluate its tracking performance of the expected puncture strength and the reproducibility of the puncture sensation. The results show that the experimental puncture strength deviates from the expected puncture strength by 0.35 N to 0.61 N in the crucial steps of breaking through the supraspinous ligament, interspinous ligament, ligamentum flavum, and dura mater, with a relative error below 10 %.

针对现有模拟器难以准确再现用针穿刺关键组织层时产生的阻力下降,以及使用体验不佳的问题,本文基于磁流变液在磁场作用下的连续可控性和快速响应性,提出了一种腰椎穿刺训练模拟器(LPTS),可全程准确模拟皮肤、皮下脂肪、棘上韧带等组织内的穿刺反馈力。通过采用双杆结构和合理布置阻尼通道间隙,最大限度地减少了组织运动过程中机械摩擦和零场阻尼力对反馈力的影响。本文介绍了原始数据的采集和建模分析,并在此基础上进行了模拟器的设计、仿真和机械测试。最后,建立了模拟器的性能测试平台,以评估其对预期穿刺强度的跟踪性能和穿刺感觉的再现性。结果表明,在突破棘上韧带、棘间韧带、黄韧带和硬脑膜的关键步骤中,实验穿刺强度与预期穿刺强度的偏差为 0.35 N 至 0.61 N,相对误差低于 10%。
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引用次数: 0
Effective cardiac disease classification using FS-XGB and GWO approach 使用 FS-XGB 和 GWO 方法进行有效的心脏病分类
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-16 DOI: 10.1016/j.medengphy.2024.104239
Daphin Lilda S, Jayaparvathy R
Globally, cardiovascular diseases (CVDs) are a leading cause of death; however, their impact can be greatly mitigated by early detection and treatment. Machine learning (ML)-based algorithms that use features extracted from electrocardiogram (ECG) signals are known to provide good accuracy in predicting various CVDs. Thus, in order to build more effective and efficient machine learning models, it is necessary to extract significant features from ECGs. In order to reduce overfitting and training overhead and improve model performance even more, feature selection or dimensionality reduction is essential. In this regard, the current work uses the grey wolf optimization (GWO) technique to pick a reduced feature set after extracting pertinent characteristics from ECG signals in order to identify five different types of CVDs. On the basis of the feature relevance of the chosen features, a feature-specific extreme gradient boosting approach (FS-XGB) is also suggested. The suggested FS-XGB classifier's performance is contrasted with that of other machine learning techniques, including gradient boosting method, AdaBoost, naïve Bayes, and support vector machine (SVM). The proposed methodology achieves a maximum classification accuracy, precision, recall, F1-score, and AUC value of 98.8 %, 100 %, 99.8 %, 100 %, and 98.8 %, respectively, with just seven optimal features, significantly fewer than the number of features used in existing works.
在全球范围内,心血管疾病(CVDs)是导致死亡的主要原因之一;然而,通过早期检测和治疗可以大大减轻其影响。众所周知,基于机器学习(ML)的算法使用从心电图(ECG)信号中提取的特征,能准确预测各种心血管疾病。因此,为了建立更有效、更高效的机器学习模型,有必要从心电图中提取重要特征。为了减少过拟合和训练开销并进一步提高模型性能,特征选择或降维至关重要。为此,本研究利用灰狼优化(GWO)技术从心电图信号中提取相关特征后,挑选出一个缩小的特征集,以识别五种不同类型的心血管疾病。根据所选特征的相关性,还提出了一种针对特定特征的极端梯度增强方法(FS-XGB)。建议的 FS-XGB 分类器与其他机器学习技术(包括梯度提升法、AdaBoost、奈夫贝叶斯和支持向量机 (SVM))的性能进行了对比。所建议的方法仅使用了七个最佳特征,就实现了最高分类准确率、精确度、召回率、F1-分数和 AUC 值,分别为 98.8%、100%、99.8%、100% 和 98.8%,大大少于现有研究中使用的特征数量。
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引用次数: 0
Crack propagation in TPMS scaffolds under monotonic axial load: Effect of morphology 单调轴向载荷下 TPMS 支架的裂纹扩展:形态的影响
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-03 DOI: 10.1016/j.medengphy.2024.104235
Aleksandr Shalimov , Mikhail Tashkinov , Ksenia Terekhina , Nataliya Elenskaya , Ilia Vindokurov , Vadim V. Silbersсhmidt

In this paper, the mechanical behaviour and failure of porous additively manufactured (AM) polylactide (PLA) scaffolds based on the triply periodic minimal surfaces (TPMS) is investigated using numerical calculations of their unit cells and representative volumes. The strain-amplification factor is chosen as the main parameter, and the most critical locations for failure of different types of scaffold structures are evaluated. The results obtained are presented in comparison with a multiple-crack-growth algorithm using the extended finite element method (XFEM), underpinned by the experimentally obtained fracture properties of PLA. The effect of morphology of TPMS structures on the pre-critical, critical and post-critical behaviours of scaffolds under monotonic loading regimes is assessed. The results provide an understanding of the fracture behaviour and main risk points for crack initiation in structures of AM-PLA scaffolds based on typical commonly used types of TPMS, as well as the influence of structure type and external load on this behaviour.

本文通过对多孔聚乳酸(PLA)支架的单元格和代表体积进行数值计算,研究了基于三周期极小表面(TPMS)的多孔添加剂制造(AM)支架的机械性能和失效。应变放大系数被选为主要参数,并评估了不同类型支架结构失效的最关键位置。在实验获得的聚乳酸断裂特性的支持下,将获得的结果与使用扩展有限元法(XFEM)的多裂缝生长算法进行了比较。评估了 TPMS 结构的形态对单调加载条件下支架的临界前、临界和临界后行为的影响。研究结果有助于了解基于典型常用 TPMS 类型的 AM-PLA 支架结构的断裂行为和裂纹萌发的主要风险点,以及结构类型和外部载荷对这种行为的影响。
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引用次数: 0
Active constraint control for the surgical robotic platform with concentric connector joints 带同心连接器关节的手术机器人平台的主动约束控制
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-02 DOI: 10.1016/j.medengphy.2024.104236
Samir Morad , Christian Ulbricht , Paul Harkin , Justin Chan , Kim Parker , Ravi Vaidyanathan

Robotic minimally invasive surgery (MIS) has changed numerous surgical techniques in the past few years and enhanced their results. Haptic feedback is integrated into robotic surgical systems to restore the surgeon's perception of forces in response to interaction with objects in the surgical environment. The ideal exact emulation of the robot's interaction with its physical environment in free space is a very challenging problem to solve completely. Previously, we introduced the surgical robotic platform (SRP) with a novel concentric connector joint (CCJ). This study aims to develop a haptic control system that integrates an active constraint controller into a surgical robot platform. We have successfully established haptic feedback control for the surgical robot using constraint control and inverse kinematic relationships integrated into the overall positioning structure. A preliminary feasibility study, modelling, and simulation were presented.

在过去几年里,机器人微创手术(MIS)改变了许多外科技术,提高了手术效果。触觉反馈被集成到机器人手术系统中,以恢复外科医生在手术环境中与物体互动时对力的感知。在自由空间中理想地精确模拟机器人与其物理环境的互动是一个极具挑战性的问题,很难完全解决。在此之前,我们介绍了带有新型同心接头(CCJ)的手术机器人平台(SRP)。本研究旨在开发一种将主动约束控制器集成到手术机器人平台的触觉控制系统。我们成功地为手术机器人建立了触觉反馈控制,将约束控制和反向运动关系集成到整体定位结构中。我们介绍了初步的可行性研究、建模和仿真。
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引用次数: 0
Computer simulation of low-power and long-duration bipolar radiofrequency ablation under various baseline impedances 计算机模拟各种基线阻抗下的低功率和长时间双极射频消融术
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-01 DOI: 10.1016/j.medengphy.2024.104226
Yao Sun , Xin Zhu , Wenxi Chen , Weihao Weng , Keijiro Nakamura

Compared to traditional unipolar radiofrequency ablation (RFA), bipolar RFA offers advantages such as more precise heat transfer and higher ablation efficiency. Clinically, myocardial baseline impedance (BI) is one of the important factors affecting the effectiveness of ablation. We aim at finding suitable ablation protocols and coping strategies by analyzing the ablation effects and myocardial impedance changes of bipolar RFA under different BIs. In this research, a three-dimensional local myocardial computer model was constructed for bipolar RFA simulation, and in vitro experimental data were used to validate accuracy. Four fixed low-power levels (20 W, 25 W, 30 W, and 35 W) and six myocardial BIs (91.02 Ω, 99.83 Ω, 111.03 Ω, 119.77 Ω, 130.03 Ω, and 135.45 Ω) were set as initial conditions, with an ablation duration of 120-s. In the context of low-power and long-duration (LPLD) ablation, the maximum TID (TIDM) decreased by 21–32 Ω, depending on the BI. In cases where steam pop did not occur, TIDM increased with the increase in power. For the same power, there was no significant difference in TIDM for the range of BIs. In cases where steam pop occurred, for every 1 Ω increase in BI, TIDM increased by 0.34–0.41 Ω. The simulation results also showed that using a higher power resulted in a smaller decrease in TIDM. This study provided appropriate ablation times and impedance decrease ranges for bipolar LPLD RFA. The combination of 25 W for 120-s offered optimal performance when considering effectiveness and safety simultaneously.

与传统的单极射频消融术(RFA)相比,双极射频消融术具有传热更精确、消融效率更高的优点。临床上,心肌基线阻抗(BI)是影响消融效果的重要因素之一。我们旨在通过分析双极射频消融术在不同基线阻抗下的消融效果和心肌阻抗变化,找到合适的消融方案和应对策略。在这项研究中,我们构建了一个三维局部心肌计算机模型用于双极 RFA 模拟,并使用体外实验数据验证其准确性。初始条件设定为四个固定的低功率水平(20 W、25 W、30 W 和 35 W)和六个心肌 BI(91.02 Ω、99.83 Ω、111.03 Ω、119.77 Ω、130.03 Ω 和 135.45 Ω),消融持续时间为 120 秒。在低功率长持续时间(LPLD)消融的情况下,最大 TID(TIDM)下降了 21-32 Ω,具体取决于 BI。在没有发生蒸汽爆裂的情况下,TIDM 随着功率的增加而增加。在相同功率下,不同 BI 的 TIDM 没有显著差异。模拟结果还显示,功率越大,TIDM 的下降幅度越小。这项研究为双极 LPLD RFA 提供了合适的消融时间和阻抗下降范围。在同时考虑有效性和安全性的情况下,25 W、120 秒的组合提供了最佳性能。
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引用次数: 0
Real-time identification of noise type contaminated in surface electromyogram signals using efficient statistical features 利用高效统计特征实时识别表面肌电信号中受污染的噪声类型
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-01 DOI: 10.1016/j.medengphy.2024.104232
Pornchai Phukpattaranont , Nantarika Thiamchoo , Paramin Neranon

Different types of noise contaminating the surface electromyogram (EMG) signal may degrade the recognition performance. For noise removal, the type of noise has to first be identified. In this paper, we propose a real-time efficient system for identifying a clean EMG signal and noisy EMG signals contaminated with any one of the following three types of noise: electrocardiogram interference, spike noise, and power line interference. Two statistical descriptors, kurtosis and skewness, are used as input features for the cascading quadratic discriminant analysis classifier. An efficient simplification of kurtosis and skewness calculations that can reduce computation time and memory storage is proposed. The experimental results from the real-time system based on an ATmega 2560 microcontroller demonstrate that the kurtosis and skewness values show root mean square errors between the traditional and proposed efficient techniques of 0.08 and 0.09, respectively. The identification accuracy with five-fold cross-validation resulting from the quadratic discriminant analysis classifier is 96.00%.

表面肌电图(EMG)信号中不同类型的噪声可能会降低识别性能。要去除噪声,首先必须识别噪声的类型。在本文中,我们提出了一种实时高效的系统,用于识别干净的肌电信号和受到以下三种噪声中任何一种噪声污染的肌电信号:心电图干扰、尖峰噪声和电源线干扰。峰度和偏度这两个统计描述符被用作级联二次判别分析分类器的输入特征。提出了一种有效的峰度和偏度计算简化方法,可以减少计算时间和内存存储。基于 ATmega 2560 微控制器的实时系统的实验结果表明,峰度和倾斜度值的均方根误差在传统技术和所提出的高效技术之间分别为 0.08 和 0.09。二次判别分析分类器的五倍交叉验证识别准确率为 96.00%。
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引用次数: 0
Analysis of the milling response of an artificial temporal bone developed for otologic surgery in comparison with human cadaveric samples 用于耳科手术的人工颞骨的铣削反应分析与人体样本的比较
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-09-01 DOI: 10.1016/j.medengphy.2024.104220
Martin Boillat , Anne-Sophie Bonnet , Frédérique Groubatch , Aude Falanga , Romain Gillet , Cécile Parietti-Winkler

Temporal-bone milling is a delicate process commonly performed during otologic surgery to gain access to the middle and inner ear structures. Because of the numerous at-risk structures of this anatomic area, extensive surgeon training is required. Artificial temporal bones offer an interesting alternative to cadaveric training. However, the evaluation of such simulators has not been systematic, with an absence of objective validation of their milling response, especially in a surgical context.

By measuring the milling forces obtained during the classical steps of otologic surgery on six 3D-printed and three cadaveric temporal bones, this work aims at evaluating the ability of the OTOtwin® synthetic temporal bone to reproduce human bone behavior.

A better repeatability was obtained for artificial bones than for cadaveric ones. However, the level of forces recorded during artificial bone milling was close to the one measured with cadaveric samples. The effects of both surgical phase and irrigation on milling force levels were also quantified. The experiments conducted in this study confirmed the suitability of OTOtwin® temporal bone model for both otologic surgery training and research purposes. Valuable insights were also gained from this study regarding the understanding of the otologic milling process.

颞骨铣削术是耳科手术中常见的精细过程,目的是进入中耳和内耳结构。由于这一解剖区域的风险结构众多,因此需要对外科医生进行广泛的培训。人工颞骨为尸体训练提供了一个有趣的替代方案。通过测量耳科手术经典步骤中在六块三维打印颞骨和三块尸体颞骨上获得的铣削力,这项工作旨在评估 OTOtwin® 合成颞骨再现人体骨骼行为的能力。然而,人工骨铣削过程中记录的力水平接近于尸体样本的测量值。此外,还量化了手术阶段和灌洗对铣削力水平的影响。本研究中进行的实验证实了 OTOtwin® 颞骨模型适用于耳科手术培训和研究目的。本研究还在了解耳科铣削过程方面获得了宝贵的见解。
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引用次数: 0
An optimal fast fractal method for breast masses diagnosis using machine learning 利用机器学习诊断乳腺肿块的最佳快速分形法
IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-23 DOI: 10.1016/j.medengphy.2024.104234
S.M.A. Beheshti

This article introduces a fast fractal method for classifying breast cancerous lesions in mammography. While fractal methods are valuable for extracting information, they often come with a high computational load and time consumption. This paper demonstrates that extracting optimal fractal information and focusing only on valuable information for classification not only improves computation speed and reduces process load but also enhances classification accuracy. To achieve this, we define an objective function based on accurate classification of benign and malignant masses to identify the best scale. Instead of extracting information from all nine scales, we extract and employ information solely from the best scale for classification. We validate the obtained scales using three classifiers: Support Vector Machine (SVM), Genetic Algorithm (GA), and Deep Learning (DL), which confirm the effectiveness of the proposed method. Comparative analysis with other studies reveals improved classification performance with the presented method.

本文介绍了一种用于乳腺 X 射线照相术中乳腺癌病灶分类的快速分形方法。虽然分形方法在提取信息方面很有价值,但它们通常会带来很高的计算负荷和时间消耗。本文证明,提取最佳分形信息并只关注有价值的信息进行分类,不仅能提高计算速度、减少处理负荷,还能提高分类准确性。为此,我们定义了一个基于良性和恶性肿块准确分类的目标函数,以确定最佳尺度。我们不再从所有九个标度中提取信息,而是只从最佳标度中提取信息并用于分类。我们使用三种分类器对获得的标度进行验证:支持向量机(SVM)、遗传算法(GA)和深度学习(DL)验证了所提方法的有效性。与其他研究的对比分析表明,所提出的方法提高了分类性能。
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引用次数: 0
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Medical Engineering & Physics
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