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Programmatic, Environmental, and Temporal Predictors of Violence, Overdose, and Self-Injury in Homeless Shelters in Toronto, Canada, 2012-2021. 加拿大多伦多市无家可归者收容中心暴力、药物过量和自残行为的规划、环境和时间预测因素,2012-2021。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1007/s11524-025-00984-x
Nick Kerman, Marcos Sanches, Sean A Kidd, Vicky Stergiopoulos

People experiencing homelessness have high rates of violent victimization, overdose, suicidality, and non-suicidal self-injury. These health-related critical incidents contribute to high mortality rates among homeless populations, making their prevention a critical public health goal. The objective of this study was to identify trends and correlates of physical violence, overdose, and self-injury in homeless shelters in Toronto, Canada. A retrospective study was conducted using administrative data on health-related critical incidents in Toronto's shelter system from 2012 to 2021. Log-linked negative binomial regression models were fitted to (a) predict physical violence, overdose, and self-injury incident counts during the study period by year, season, and pandemic onset, and (b) examine programmatic, environmental, and temporal correlates of these outcomes, with separate analyses performed for the pre-pandemic and pandemic periods. Shelter-based physical violence (incidence rate ratio [IRR] 1.08; 95% confidence interval [CI] 1.06-1.11), overdose (IRR 1.20; CI 1.13-1.26), and self-injury (IRR 1.16; CI 1.11-1.21) incidents increased over the study period, with the rates of the increases for violence (IRR 1.10; CI 1.00-1.20) and overdoses (IRR 1.66; CI 1.48-1.86) intensifying during the COVID-19 pandemic. Larger congregate shelters had higher rates of violence, overdose, and self-injury, whereas shelter-based hotels had lower incident rates. Critical incidents were also higher during the winter, and there was an increased rate of overdoses during cheque week. The development of smaller shelters that offer greater privacy to service users warrants further examination to advance safety in shelter settings. Increasing access to naloxone and other substance use supports, especially during check week, is also recommended for reducing drug-related harms.

无家可归的人遭受暴力侵害、吸毒过量、自杀和非自杀性自残的比例很高。这些与健康有关的重大事件导致无家可归者死亡率高,因此预防这些事件成为一项重要的公共卫生目标。本研究的目的是确定加拿大多伦多无家可归者收容所中身体暴力、药物过量和自残的趋势和相关性。利用2012年至2021年多伦多收容所系统中与健康相关的重大事件的行政数据进行了一项回顾性研究。拟合Log-linked负二项回归模型,以(a)在研究期间按年份、季节和大流行发病预测身体暴力、过量用药和自残事件计数,以及(b)检查这些结果的规划、环境和时间相关性,并对大流行前和大流行期间进行单独分析。基于庇护所的身体暴力(发生率比[IRR] 1.08;95%可信区间[CI] 1.06-1.11),过量用药(IRR 1.20;CI 1.13-1.26),自伤(IRR 1.16;CI 1.11-1.21)事件在研究期间有所增加,暴力事件的增长率(IRR 1.10;CI 1.00-1.20)和过量用药(IRR 1.66;CI(1.48-1.86)在COVID-19大流行期间加剧。较大的收容所的暴力、吸毒过量和自残率较高,而以收容所为基础的酒店的事故率较低。严重事故在冬季也较高,在支票周期间过量服用的比率也有所增加。为服务使用者提供更大隐私的小型庇护所的发展值得进一步审查,以提高庇护所设置的安全性。还建议增加纳洛酮和其他物质使用支持,特别是在检查周期间,以减少与毒品有关的危害。
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引用次数: 0
Gun Free Zones in Alcohol-Serving Establishments and Risk for Firearm Violence: A Cross-Sectional, Geospatial Study in Texas. 酒类供应场所的无枪区与枪支暴力风险:德克萨斯州的一项横断面地理空间研究。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 DOI: 10.1007/s11524-024-00928-x
Paul M Reeping, Hannah S Laqueur, Rose M C Kagawa

To date, there have been no peer-reviewed studies in the United States estimating the impact of gun-free zone policies in alcohol-serving establishments on rates of firearm violence in and around such establishments. In this study, we utilized a cross-sectional design to estimate the impact of Texas's 51% alcohol law, which prohibits the carrying of firearms in establishments that generate over half of their revenue from alcohol sales. The analysis focused on the difference in shooting incidents in and around establishments with and without firearm carrying prohibitions in 2021 and 2022. After adjusting for establishment type (bar/restaurant), alcohol sales volume, census tract level demographic factors, and the number of nearby restaurants and bars, results indicated that gun-prohibiting bars experienced significantly fewer shootings compared to those that allowed guns. Specifically, establishments that were gun-prohibited had 37% fewer shootings within 50 m than those that were gun-allowing, with a 95% confidence interval ranging from 60% fewer to 0.2% fewer. This association was more prominent in bars than in restaurants. The protective association with gun-prohibited status diminished with increased distance from the establishments; results were not significant at 100 m. Our study findings align with research suggesting that gun-free zones can reduce firearm violence. However, future studies using quasi-experimental designs that can better support causal inference are needed to support such a conclusion, as are studies exploring the efficacy of such policies in various settings and over longer periods.

迄今为止,美国还没有同行评议研究估计过酒类供应场所的无枪区政策对此类场所内及周边枪支暴力事件发生率的影响。在本研究中,我们采用横截面设计来估算得克萨斯州 51% 酒精法的影响,该法禁止在酒类销售收入超过一半的场所携带枪支。分析的重点是 2021 年和 2022 年禁止携带枪支和不禁止携带枪支的场所及其周围发生的枪击事件的差异。在对场所类型(酒吧/餐馆)、酒类销售量、人口普查区人口因素以及附近餐馆和酒吧的数量进行调整后,结果表明,与允许持枪的场所相比,禁止持枪的酒吧发生的枪击事件要少得多。具体而言,与允许持枪的场所相比,禁止持枪的场所在 50 米范围内发生的枪击事件要少 37%,95% 的置信区间从少 60% 到少 0.2% 不等。这种关联在酒吧比在餐馆更为突出。与禁枪区的保护性关联随着与禁枪区距离的增加而减弱;在距离禁枪区 100 米时,结果并不显著。然而,未来的研究还需要使用准实验设计来更好地支持因果推论,以支持这一结论,同时还需要研究探索此类政策在不同环境和较长时间内的有效性。
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引用次数: 0
The Economic Burden of Healthcare Utilization: Findings from a Health and Well-Being Survey in Informal Settlements of Freetown, Sierra Leone. 医疗保健利用的经济负担:来自塞拉利昂弗里敦非正式住区健康和福祉调查的结果。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1007/s11524-025-00960-5
Sullaiman Fullah, Dora Vangahun, Ibrahim Gandi, Sia Morenike Tengbe, Braima Koroma, Samira Sesay, Eliud Kibuchi, Rajith W D Lakshman, Ibrahim Juldeh Sesay, Abu Conteh, Samuel Saidu, Helen Elsey, Zahidul Quayyum, Bintu Mansaray, Lana Whittaker, Neele Wiltgen Georgi, Motto Nganda, Rachel Tolhurst, Noemia Teixeira de Siqueira Filha

The fragile health system in Sierra Leone undermines healthcare, leading to substantial patient costs. We aimed to estimate the economic burden and inequalities in healthcare in urban informal settlements in Freetown, Sierra Leone. A cross-sectional survey was conducted in three informal settlements in Freetown in April and May 2023 to collect data on healthcare usage within and outside the boundaries of the informal settlements. Catastrophic expenditures were estimated using the payer's household budget. Logistic regression explored socioeconomic characteristics associated with catastrophic expenditures. Inequalities in healthcare expenditures were assessed through concentration curves and indices. A total of 2575 participants reported healthcare utilization. Dwarzark (US$6.9) and Moyiba (US$7.1) had higher costs than Cockle Bay (US$5.5) when utilizing healthcare within the communities. Households incurred higher costs when seeking healthcare outside their informal settlements than within (US$14 vs US$ 7). Over half of the households across the settlements incurred catastrophic expenditures when seeking care outside the communities (57%), with the poorest wealth quintile (poorest, 89%; wealthier, 12%) incurring in higher incidence. Attending informal healthcare had a protective effect against catastrophic expenditure for healthcare within the communities. Age + 35, residence in Dwarzark and Moyiba, and length of residence + 4 years were associated with catastrophic expenditures. Healthcare expenditure was progressive in Dwarzark and equally distributed across wealth quintiles in the other communities. Our findings indicate the need to provide accessible, affordable, and good-quality healthcare within communities to alleviate the catastrophic costs of healthcare utilization. The regulation of informal health providers and their integration into the formal health system should be considered.

塞拉利昂脆弱的卫生系统破坏了医疗保健,导致患者花费巨大。我们的目的是估计塞拉利昂弗里敦城市非正规住区的经济负担和医疗保健不平等。2023年4月和5月在弗里敦的三个非正式住区进行了一项横断面调查,以收集关于非正式住区边界内外医疗保健使用情况的数据。灾难性支出是根据付款人的家庭预算估算的。逻辑回归探讨了与灾难性支出相关的社会经济特征。通过浓度曲线和指数评估医疗支出的不平等。共有2575名参与者报告了医疗保健利用情况。当在社区内利用医疗保健时,Dwarzark(6.9美元)和Moyiba(7.1美元)的成本高于Cockle Bay(5.5美元)。家庭在其非正式住区外寻求医疗保健的费用高于在其非正式住区内寻求医疗保健的费用(14美元对7美元)。住区中超过一半的家庭在社区外寻求医疗保健时产生了灾难性支出(57%),其中最贫穷的五分之一(最贫穷,89%;更富裕,12%),发病率更高。参加非正式保健对防止社区内的灾难性保健支出具有保护作用。年龄≥35岁,居住在Dwarzark和Moyiba,居住时间≥4年与灾难性支出相关。在Dwarzark,医疗保健支出是渐进式的,在其他社区,医疗保健支出在财富五分位数之间平均分配。我们的研究结果表明,需要在社区内提供可获得的、负担得起的和高质量的医疗保健,以减轻医疗保健利用的灾难性成本。应考虑对非正规保健提供者进行管制并将其纳入正规保健系统。
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引用次数: 0
Spatiotemporal Analysis of Fentanyl-Associated Overdose Deaths in Chicago, IL, USA. 美国伊利诺伊州芝加哥市芬太尼相关过量死亡的时空分析
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.1007/s11524-025-00986-9
Hyojung Kang, Kaylee Janakos, Csaba Varga

Overdose deaths involving fentanyl represent a major public health crisis in the USA. This study investigates the spatiotemporal dynamics of fentanyl-involved deaths before, during, and after the COVID-19 pandemic and examines how sociodemographic factors influence these deaths across geographic regions. Using a retrospective ecological approach, we analyzed data on ZIP code-level fentanyl-related deaths in Cook County, IL, between 2018 and 2023, obtained from the Medical Examiner's Office and linked with sociodemographic data from the American Community Survey. We first mapped area-level death rates to assess their distribution and then conducted global and local clustering analyses to identify spatial autocorrelations and the locations of high- or low-death-rate areas. A geographically weighted Poisson regression (GWPR) model evaluated the associations between area-level fentanyl-related death rates and the area-level proportion of young adults, males, and individuals with at least a college degree, disability rate, and poverty rate. Spatial analyses found stronger spatial autocorrelations during (2020-2021) and after (2022-2023) the pandemic. Initially, high death rates were concentrated in the downtown area of Chicago, and they expanded to the surrounding areas during and after the pandemic. The GWPR model revealed that an increase in the area-level proportions of poverty, disability, and young adult residents increased the fentanyl-related death rates in most of the areas. Our findings highlight the urgent need to address the evolving dynamics of fentanyl-related overdoses through tailored public health interventions that account for the unique socioeconomic determinants of different regions. Importantly, a comprehensive approach to addressing differences in overdose death rates and their risk factors will be crucial to mitigating this public health crisis.

涉及芬太尼的过量死亡是美国的一项重大公共卫生危机。本研究调查了COVID-19大流行之前、期间和之后芬太尼相关死亡的时空动态,并研究了社会人口因素如何影响跨地理区域的这些死亡。使用回顾性生态学方法,我们分析了2018年至2023年期间伊利诺伊州库克县邮政编码级别芬太尼相关死亡的数据,这些数据来自法医办公室,并与美国社区调查的社会人口统计数据相关联。我们首先绘制了区域一级的死亡率图以评估其分布,然后进行了全球和局部聚类分析,以确定空间自相关性以及高或低死亡率地区的位置。地理加权泊松回归(GWPR)模型评估了地区芬太尼相关死亡率与年轻人、男性和至少拥有大学学位的个体的地区比例、残疾率和贫困率之间的关系。空间分析发现,大流行期间(2020-2021年)和之后(2022-2023年)的空间自相关性更强。最初,高死亡率集中在芝加哥市中心地区,在大流行期间和之后,死亡率扩大到周边地区。GWPR模型显示,在大多数地区,贫困、残疾和年轻成年居民的区域比例增加增加了芬太尼相关的死亡率。我们的研究结果强调,迫切需要通过量身定制的公共卫生干预措施来解决芬太尼相关过量用药的演变动态,这些干预措施考虑了不同地区独特的社会经济决定因素。重要的是,采取综合办法解决过量死亡率及其风险因素的差异,对于减轻这一公共卫生危机至关重要。
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引用次数: 0
From Vulnerability to Strength: Transforming Health Systems for Climate Resilience. 从脆弱到强大:转变卫生系统以适应气候变化。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-04-04 DOI: 10.1007/s11524-025-00972-1
Musa Hussain, Nashmia Khan, Grace Morton, Elana Kieffer, Ann Kurth

In the face of escalating climate-related challenges, the resilience of healthcare systems is paramount. As was seen during COVID-19, the climate crisis exemplifies the critical need for a resilient workforce and robust healthcare infrastructure amidst increasing impacts including infrastructure disruptions, rising costs, and exacerbated health disparities. Structurally vulnerable communities, particularly those of color, face disproportionate exposure to climate risks, highlighting the urgent need for equitable resilience strategies. A focus on multifaceted approaches to fortifying healthcare systems against climate change includes emphasizing decarbonization, adaptability, data-driven planning, and support of sustainable infrastructure and health workers. The importance of integrating climate awareness into clinical and public health practices is underscored, promoting proactive measures and community engagement. Strategies to mitigate carbon footprint and enhance healthcare delivery can be enacted including with some federal and philanthropic funding support. This comprehensive approach ensures that healthcare systems remain robust, equitable, and responsive in the face of ongoing and future climate crisis challenges.

面对不断升级的气候相关挑战,医疗保健系统的复原力至关重要。正如在 COVID-19 期间所看到的那样,气候危机表明,在基础设施中断、成本上升和健康差异加剧等影响日益严重的情况下,亟需一支具有抗灾能力的劳动力队伍和强大的医疗保健基础设施。结构脆弱的社区,尤其是有色人种社区,面临着不成比例的气候风险,这突出表明迫切需要制定公平的抗灾战略。加强医疗保健系统应对气候变化的多层面方法包括强调去碳化、适应性、数据驱动的规划,以及支持可持续的基础设施和医疗工作者。将气候意识纳入临床和公共卫生实践的重要性得到了强调,促进了积极主动的措施和社区参与。在联邦和慈善机构的资金支持下,可以制定减少碳足迹和改善医疗服务的战略。这种全面的方法可确保医疗保健系统在面对当前和未来气候危机的挑战时保持稳健、公平和反应迅速。
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引用次数: 0
A Computational Approach to Analyzing Spatiotemporal Trends in Gun Violence and Mental Health Disparities among Racialized Communities in US Metropolitan Areas. 美国大都市地区种族化社区枪支暴力与心理健康差异时空趋势分析的计算方法
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1007/s11524-025-00976-x
Fahimeh Mohebbi, Amir Masoud Forati, John R Mantsch, Madeline Campbell, Rina Ghose

Gun violence is a leading cause of death and injuries in the USA, adversely affecting physical and mental health among its survivors. Declared as a public health crisis in 2024, It disproportionately affects African Americans. It is linked to discriminatory policies like "redlining," which fostered racial segregation and systemic inequities, perpetuating cycles of violence and mental health disparities. This study explores the relationships between racial segregation, systemic inequities, gun violence, and mental health through a data-driven, longitudinal study (2005-2021) of Milwaukee, WI, a hyper segregated metropolitan region. Our investigation aims to inform evidence-based, place-sensitive policies to promote social justice, reduce disparities, and foster healthy communities. Utilizing location-based demographic and socio-economic data from the U.S. Census, gun violence data from the Wisconsin Incident-Based Reporting System, and mental health data from the CDC's PLACES dataset, we conduct spatial and temporal analyses and geovisualization in GIS. To understand trends and correlations, we conduct time series decomposition, Mann-Kendall trend tests, and entropy statistics. Our findings indicate that racially segregated neighborhoods experience higher rates of gun violence and poorer mental health outcomes. Predominantly African American neighborhoods exhibit patterns of "consecutive," "sporadic," and "new" hotspots of gun violence, while predominantly white neighborhoods are characterized as "cold spots." Physical and mental health disparities in Milwaukee indicate similar patterns. The results of this study highlight the profound impact of historical and systemic socioeconomic discrimination on contemporary public health issues.

在美国,枪支暴力是造成死亡和受伤的主要原因,对幸存者的身心健康产生了不利影响。它在2024年被宣布为公共卫生危机,对非洲裔美国人的影响尤为严重。它与“划红线”等歧视性政策有关,这些政策助长了种族隔离和系统性不平等,使暴力和心理健康差距的循环永久化。本研究通过一项数据驱动的纵向研究(2005-2021),探讨了种族隔离、系统性不平等、枪支暴力和心理健康之间的关系,该研究是在威斯康星州密尔沃基这个高度隔离的大都市区进行的。我们的调查旨在为以证据为基础的地方敏感政策提供信息,以促进社会正义,减少差距,并促进健康的社区。利用美国人口普查中基于地理位置的人口统计和社会经济数据、威斯康星州事件报告系统中的枪支暴力数据以及疾病预防控制中心PLACES数据集中的心理健康数据,我们在GIS中进行了时空分析和地理可视化。为了理解趋势和相关性,我们进行了时间序列分解、Mann-Kendall趋势检验和熵统计。我们的研究结果表明,种族隔离社区的枪支暴力发生率更高,心理健康状况也更差。以非洲裔美国人为主的社区呈现出“连续”、“零星”和“新”枪支暴力热点的模式,而以白人为主的社区则被定性为“冷点”。密尔沃基的身心健康差异也显示出类似的模式。本研究的结果强调了历史和系统的社会经济歧视对当代公共卫生问题的深刻影响。
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引用次数: 0
Do Rental Assistance Programs Relieve Overcrowding for Children? 租房援助计划能缓解儿童的过度拥挤吗?
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 DOI: 10.1007/s11524-025-00979-8
Frank Zhu, Andrew Fenelon, Penelope Schlesinger, Danya E Keene

Crowded living conditions are associated with negative health outcomes, particularly for children. Federal rental assistance may reduce household crowding by improving access to affordable housing for low-income families. We leveraged NHANES data linked with HUD administrative rental assistance records to examine relationships between different forms of HUD rental assistance and multiple measures of crowding for households with children. We found a statistically significant reduction in the odds of crowding for those currently receiving HUD assistance compared to a control group who entered rental assistance within 2 years of their NHANES interview (95% CI, 0.39 to 0.93). The specific relationships between rental assistance and crowding and the magnitude of these associations varied by rental assistance type (public housing, multi-family, and vouchers). Fewer than 1 in 4 eligible households receive rental assistance. Our findings suggest that expanding access to this resource can reduce household crowding and its adverse impacts on health and well-being.

拥挤的生活条件与不利的健康结果有关,特别是对儿童而言。联邦租金援助可以通过改善低收入家庭获得负担得起的住房的机会来减少家庭拥挤。我们利用NHANES数据与HUD行政租赁援助记录相关联,研究了不同形式的HUD租赁援助与有孩子的家庭拥挤程度的多种衡量标准之间的关系。我们发现,与NHANES访谈后2年内进入租房援助的对照组相比,目前接受HUD援助的人群拥挤的几率有统计学意义上的显著降低(95% CI, 0.39至0.93)。租赁援助与拥挤之间的具体关系以及这些关联的程度因租赁援助类型(公共住房、多户家庭和代金券)而异。不到四分之一的合资格家庭获得租金援助。我们的研究结果表明,扩大对这种资源的获取可以减少家庭拥挤及其对健康和福祉的不利影响。
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引用次数: 0
Correction: Spatiotemporal Analysis of Fentanyl-Associated Overdose Deaths in Chicago, IL, USA. 更正:美国伊利诺伊州芝加哥市芬太尼相关过量死亡的时空分析。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 DOI: 10.1007/s11524-025-00993-w
Hyojung Kang, Kaylee Janakos, Csaba Varga
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引用次数: 0
The Price of Denial: Examining the Health Consequences of Mortgage Lending Bias in Michigan Metro Areas. 拒绝的代价:检查在密歇根都市地区抵押贷款偏见的健康后果。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-06-11 DOI: 10.1007/s11524-025-00985-w
Jamison Koeman, Wenchu Pan, Alexa Eisenberg, Lu Wang, Roshanak Mehdipanah

Anti-Black mortgage lending discrimination (MLD) has resulted in homeownership disparities among White and Black households. This study examines the association between MLD and health opportunities, based on various neighborhood determinants of health (e.g., employment, education, and housing status), in Michigan's three largest metropolitan areas. Multilevel models using data from the Home Mortgage Disclosure Act and Census from 2015 to 2019 were used to examine the Black-White odds ratio of mortgage denial. An association analysis was performed to examine the relationship between the Black-White odds ratio of mortgage denial and neighborhood health opportunities. Loan denial for Black mortgage applicants was 1.99 (95% CI1.87, 2.12) times more likely than for White applicants. Neighborhoods with greater anti-Black MLD had fewer harmful environmental exposures, greater health insurance coverage, and better housing and socio-economic conditions. Anti-Black MLD remains a common practice and supports the assertion that Black home-seekers experience greater MLD in neighborhoods with better opportunities for health compared to White home-seekers, who access these benefits more freely. Greater protections against MLD-including increasing oversight of the data reporting requirements and improving mortgage access for Black households-are needed to promote health equity.

反黑人抵押贷款歧视(MLD)导致了白人和黑人家庭住房拥有率的差异。本研究基于密歇根州三个最大大都市地区的各种社区健康决定因素(如就业、教育和住房状况),探讨了MLD与健康机会之间的关系。利用2015年至2019年《住房抵押贷款披露法》和人口普查数据的多层次模型,研究了黑人和白人拒绝抵押贷款的几率比。我们进行了关联分析,以检验拒绝抵押贷款的黑人-白人比值比与邻里健康机会之间的关系。黑人抵押贷款申请人被拒绝贷款的可能性是白人申请人的1.99倍(95% CI1.87, 2.12)。反黑人MLD程度较高的社区有害环境暴露较少,健康保险覆盖面较大,住房和社会经济条件也较好。反黑人的MLD仍然是一种常见的做法,并支持这样一种说法,即与白人寻求住房者相比,黑人寻求住房者在拥有更好健康机会的社区中经历了更大的MLD,后者更自由地获得这些福利。为了促进健康公平,需要加强对mld的保护,包括加强对数据报告要求的监督和改善黑人家庭的抵押贷款。
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引用次数: 0
Pharmacy Homeless Outreach Engagement Non-medical Independent Prescribing Rx (PHOENIx) Community Pharmacy-Based Pilot Randomized Controlled Trial. 药房无家可归者外展参与非医疗独立处方Rx (PHOENIx)社区药房试点随机对照试验。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1007/s11524-025-00981-0
Richard Lowrie, Vibhu Paudyal, Andrew McPherson, Helena Heath, Jane Moir, Natalie Allen, Nigel Barnes, Hugh Hill, Adnan Araf, Cian Lombard, Steven Ross, Sarah Tearne, Parbir Jagpal, Versha Cheed, Lee Middleton, Shabana Akhtar, George Provan, Jennifer Hislop, Andrea Williamson, Frances S Mair

Randomized controlled trials (RCTs) aiming to address the multiple health and social challenges of people experiencing homelessness (PEH) are lacking. Here we report the findings from a multicenter, open, pilot RCT. The intervention involved independent prescriber pharmacist from the National Health Service working on outreach in partnership with dedicated workers from Homeless Voluntary Charity or Social Enterprises (HVCSEs) (Pharmacist and third sector charity worker integrated Homeless Outreach Engagement Non-medical Independent prescriber Rx'-PHOENIx) in low threshold HVCSE venues or temporary accommodation addressing PEH participants' health and wider needs through repeated outreach. The trial aimed to investigate whether sufficient numbers of participants could be recruited, retained, the intervention delivered as planned, and sufficient data collected to inform a subsequent definitive RCT. Clinical outcomes were also collected at follow-up (6 months). Participants were recruited from five community pharmacies and nearby venues in urban centers of Glasgow-Scotland and Birmingham-England, then randomized one-to-one into PHOENIx intervention in addition to usual care (UC) or UC only. A priori progression criteria were achieved: 55% of those assessed as eligible were recruited; at 6 months, 72% remained in the study, 91% had emergency department and mortality data available, and 72% completed questionnaire booklets. Fifty-three percent of participants received at least 50% of the planned PHOENIx intervention consultations (in-person or phone) at 6 months. Signs of improvement in clinical outcomes in the PHOENIx group included fewer ambulance call-outs, ED visits, and hospitalizations; higher outpatient attendances; and higher scores on self-reported health-related quality of life. A definitive RCT is merited.

缺乏旨在解决无家可归者面临的多重健康和社会挑战的随机对照试验。在此,我们报告了一项多中心、开放、试点随机对照试验的结果。干预涉及来自国家卫生服务的独立处方药剂师与来自无家可归者志愿慈善机构或社会企业(HVCSEs)的专职工作人员合作开展外展工作(药剂师和第三部门慈善工作者整合了无家可归者外展参与非医疗独立处方处方Rx'-PHOENIx),在低门槛的HVCSE场所或临时住所通过反复外展解决PEH参与者的健康和更广泛的需求。该试验旨在调查是否可以招募、保留足够数量的参与者,干预措施是否按计划进行,以及收集到足够的数据来为随后的最终RCT提供信息。在随访(6个月)时收集临床结果。参与者从格拉斯哥-苏格兰和伯明翰-英格兰城市中心的五个社区药店和附近的场所招募,然后随机分为一对一的PHOENIx干预和常规护理(UC)或仅UC。达到先验进展标准:55%被评估为合格的人被招募;6个月时,72%的人仍在研究中,91%的人有急诊科和死亡率数据,72%的人完成了问卷小册子。53%的参与者在6个月时接受了至少50%的凤凰计划干预咨询(面对面或电话)。PHOENIx组临床结果改善的迹象包括救护车呼叫、急诊科就诊和住院次数减少;更高的门诊人次;自我报告的健康相关生活质量得分更高。值得进行一项明确的随机对照试验。
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Journal of Urban Health-Bulletin of the New York Academy of Medicine
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