Kudzu, a perennial climbing vine and invasive species to the American South, occupied a unique space in the city of Atlanta, Georgia as a danger to public health from the late 1970s to the early 1990s. This article examines why municipal authorities understood the vine as a threat to public health. Kudzu's ability to smother surfaces allowed it to conceal murdered people and serve as a habitat for rats, snakes, and mosquitos, making it a direct threat to public safety in the eyes of public health authorities. Kudzu also grew extensively in vacant lots where city officials were trying to promote the city as progressive and prosperous. The city council voted in support of an ordinance against extensive growths of the vine, but eradication produced its own challenges: kudzu removal was expensive, and permanent eradication required large investments in time. Unhoused people also relied on the vine for shelter, which meant that eradication directly affected their safety. Examining how municipal authorities framed kudzu as a threat to public health, this article demonstrates that the vine's status as a health risk lay in how it unintentionally clashed with the promoted image of Atlanta as a business-friendly city with harmonious relationships among its citizens.