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Investigation of bone biomechanics in rats with traumatic kidney injury 创伤肾损伤大鼠骨生物力学研究
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_164_22
Asrın Nalbant, Duygu Saygin, A. Aydın, Anıl Didem Aydın Kabakçı
Objective: Mineral metabolism disorders are common in chronic kidney disease (CKD) and increase the risk of fractures. It has been confirmed by animal models that these changes in bone also cause negative results in the mechanical properties of bone. Although there are many available methods for diagnosing metabolic bone disorders and estimating fracture risk, it has been suggested that biomechanical tests that provide information about bone's structural and material properties are most appropriate, particularly in small rodents with CKD. Therefore, this study aimed to investigate the effects of trauma-induced kidney damage on bone biomechanical properties. Materials and Methods: In this study, we used 16 adult Wistar Albino rats, 200–300 g, 4–5 months old. The animals were examined under two groups: kidney control (n = 9) and healty kidney control group and kidney damage group (n = 7). In the control group, the rats were fixed by laparotomy, and the kidneys were closed without suturing. However, the kidney damage group was approached by suturing. Results: When the bone biomechanical properties of the control and kidney-damaged groups were compared, a statistically significant difference was found between the displacement at maximum load, duration, and young's modulus groups (P < 0.005). Conclusion: The study showed that the bone biomechanical properties of rats with trauma-induced kidney damage changed, and there was an increased fracture risk.
目的:矿物质代谢紊乱在慢性肾脏疾病(CKD)中很常见,并增加骨折的风险。动物模型已经证实,骨骼的这些变化也会导致骨骼力学性能的负面结果。尽管有许多可用的方法来诊断代谢性骨疾病和估计骨折风险,但有人认为,提供骨骼结构和材料特性信息的生物力学测试是最合适的,尤其是在患有CKD的小型啮齿动物中。因此,本研究旨在探讨创伤引起的肾脏损伤对骨生物力学特性的影响。材料和方法:在本研究中,我们使用了16只成年Wistar Albino大鼠,200-300 g,4-5个月大。将动物分为两组:肾脏对照组(n=9)、健康肾脏对照组和肾脏损伤组(n=7)。在对照组中,大鼠通过剖腹手术固定,并且在不缝合的情况下闭合肾脏。然而,肾损伤组通过缝合来接近。结果:当比较对照组和肾损伤组的骨生物力学特性时,最大负荷、持续时间和杨氏模量组之间的位移差异具有统计学意义(P<0.005),骨折风险增加。
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引用次数: 0
Morphometric evaluation of the human corpus callosum using magnetic resonance imaging: Sex difference and relationship to age and intracranial size 人类胼胝体的磁共振成像形态学评价:性别差异及其与年龄和颅内大小的关系
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_185_21
I. Tuncer
Introduction: The objective of this study was to determine the normal values of corpus callosum (CC) subregions in healthy adult individuals in our population using magnetic resonance imaging (MRI) and to reveal gender differences during normal aging. Material and Methods: We performed the measurements of certain CC dimensions in 104 (44 males and 60 females) individuals. MRI imaging device was used for the measurements. The subregions of CC were measured with the midsagittal images. After the measurements of CC and its sections' (rostrum [R], genus [G], anterior body, posterior body, isthmus [I], and splenium [S]), length (L), width (W), and area (A) were carried out, the intracranial volume (ICV) and intracranial area (ICA) values were calculated. The Student's t-test and Pearson correlation test were used for statistical analysis. Results: Morphometric data of length, width, area, ICV, and ICA were collected. No significant difference was identified in CC morphometry by age among the patients (P > 0.05). Indicating longer diameters in males, the differences between the genders were significant (P < 0.05). Moreover, the mean of R-L, G-A, and G-W measurements was found significant between the age groups (P < 0.001). Conclusion: Sexual dimorphism in the CC is not a simple artifact of sex differences in brain size and may reflect differences in connectivity necessitated by differences in brain sizes.
简介:本研究的目的是利用磁共振成像(MRI)确定我国人群中健康成人胼胝体(CC)亚区的正常值,并揭示正常衰老过程中的性别差异。材料和方法:我们测量了104个个体(男性44个,女性60个)的某些CC尺寸。采用核磁共振成像仪进行测量。中矢状面图像测量CC亚区。在测量CC及其切片(体表[R]、属[G]、前体、后体、峡部[I]、脾[S])、长度(L)、宽度(W)、面积(A)后,计算颅内容积(ICV)和颅内面积(ICA)值。采用学生t检验和Pearson相关检验进行统计分析。结果:采集了长、宽、面积、ICV、ICA的形态计量学数据。不同年龄的患者CC形态差异无统计学意义(P < 0.05)。雄性虫径较长,性别间差异有统计学意义(P < 0.05)。此外,R-L、G-A和G-W测量值的平均值在年龄组之间具有显著性(P < 0.001)。结论:CC的性别二态性不是脑大小性别差异的简单产物,它可能反映了脑大小差异所必需的连接差异。
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引用次数: 0
Evaluation of the Ponticulus Posticus with Cone-beam Computed Tomography in a Turkish Population 圆锥束计算机断层扫描评价土耳其人群的Posticulus
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_188_21
Ş. Erdem, K. Gündüz, P. Kasap
Introduction: The aim of this study was to investigate the incidence of ponticulus posticus (PP) in a sample population with cone-beam computed tomography (CBCT). Materials and Methods: The images of 1000 patients who were examined CBCT were analyzed retrospectively. The frequency of PP was evaluated. The presence of complete or partial PP in the atlas was examined on reformed sagittal cross-sectional images. Results: It was found that PP was detected in 250 patients (25%). When the prevalence of PP among gender was examined, it was found that 129 (24.2%) of 533 females and 121 (25.9%) of 467 males had PP. Complete PP was detected in 142 patients and partial PP was detected in a total of 151 patients. Discussion and Conclusion: In conclusion, PP is a common variation of the atlas. The increase in the frequency of complete PP and the decrease in the frequency of partial PP in older age groups suggested that there may be a correlation between age and PP formation.
引言:本研究的目的是用锥形束计算机断层扫描(CBCT)研究样本人群中后桥(PP)的发病率。材料与方法:对1000例接受CBCT检查的患者的影像资料进行回顾性分析。对PP的频率进行了评估。在改良的矢状截面图像上检查图谱中是否存在完全或部分PP。结果:在250例(25%)患者中检测到PP。当检查不同性别的PP患病率时,发现533名女性中有129人(24.2%)患有PP,467名男性中有121人(25.9%)患有PP。142名患者中检测到完全PP,151名患者中共检测到部分PP。讨论和结论:总之,PP是图谱的常见变体。在老年组中,完全PP频率的增加和部分PP频率的降低表明年龄和PP的形成之间可能存在相关性。
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引用次数: 0
Embryogenesis and histogenesis of the human fetal liver at various stages of gestation 妊娠不同阶段人类胎儿肝脏的胚胎发生和组织发生
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_148_22
P. Bhadoria, Kavita Modi, Brijendra Singh, J. Chaturvedi, Amarjyoti Chaturvedi, Bhavaniprasad Mahindrakar
Background of Study: To assess the prenatal development of the human liver at gestation ages (GAs) 12–36 weeks using microscopic parameters and their correlation to predict the GA. The observation of microscopic features such as Kupffer cells (KCs), hematopoietic activity, stellate cells, glycogen granules, central vein (CV), and portal triad (PT) carries immense importance for its use in the estimation of fetal GA, detection of anatomical variations, and identification of congenital anomalies concerning branches such as anatomy, surgery, forensic sciences, radiology, pediatrics, and phytopathology. Materials and Methods: The present study was conducted in the department of anatomy on 33 normal fetuses of GA 12–36 weeks and classified them into 5 groups as A (12–16 weeks), B (17–21 weeks), C (22–26 weeks), D (27–31 weeks), and E (32–36 weeks). The general parameters were measured. Slides were prepared as per standard protocol and observed under a light microscope. Results: Microscopic observation reveals CV and PT in 15 weeks, dominant hematopoiesis till 21 weeks and then declines gradually, KC in 16 weeks, sinusoids in 19 weeks, glycogen granules deposition from 36 weeks, and hepatic lobule and portal lobule appears at 31 weeks. Conclusion: The knowledge of morphological features with respect to gestational age is a reliable reference help to prevent misdiagnosis of various pathological conditions of the liver such as cirrhosis, hepatomegaly, fetal anemia, intrauterine growth retardation, and congenital anomalies.
研究背景:使用显微镜参数及其相关性来预测妊娠12–36周时人类肝脏的产前发育。观察库普弗细胞(KCs)、造血活性、星状细胞、糖原颗粒、中央静脉,门脉三联体(PT)在评估胎儿GA、检测解剖变异和识别先天性异常方面具有巨大的重要性,涉及解剖学、外科学、法医学、放射学、儿科和植物病理学等分支。材料和方法:本研究在解剖学部门对33例GA 12–36周的正常胎儿进行了研究,并将其分为5组,分别为A组(12–16周)、B组(17–21周)、C组(22–26周)、D组(27–31周)和E组(32–36周)。测量了一般参数。按照标准方案制备载玻片,并在光学显微镜下观察。结果:镜下观察15周CV和PT,21周主要造血,然后逐渐下降,16周KC,19周血窦,36周糖原颗粒沉积,31周出现肝小叶和门脉小叶。结论:了解与胎龄有关的形态学特征有助于防止肝硬化、肝肿大、胎儿贫血、宫内发育迟缓和先天性畸形等各种肝脏病理状况的误诊。
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引用次数: 0
Neuroanatomy of stroke: A computed tomography-based topographic analysis 脑卒中的神经解剖学:基于计算机断层扫描的地形图分析
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_112_22
Sonali Subhadarsini, Aboobacker Shani, D. Mishra
Background: The present study is a computed tomography (CT)-based topographic analysis of cerebral stroke that constitutes the distribution of infarction and hemorrhage with respect to different neuro-anatomical structures. CT scanning is the easily affordable technique in India for the accurate diagnosis of cerebral stroke. Aim: The aim of the present study is to evaluate the incidence of brain stroke by CT scan in patients with cerebrovascular accidents. Subjects and Methods: Patients with cerebrovascular accidents were subjected to CT scan of the head using GE Revolution ACTs 16 slice multi-detector row CT scanners, slice thickness – 2 mm, 5 mm, and 10 mm and matrix size of 512 × 512. The incidence of stroke in patients over 20 years of age at SCB Medical College was evaluated during the period 2019–2021. The incidence of stroke was studied according to age, sex, and stroke subtype with arterial involvement. Results: The topography of brain infarction was highly variable with all regions of the middle cerebral artery (MCA) territory. There were 190 ischemic and 106 hemorrhagic stroke cases out of 296 patients. The mean age was 55.28 ± 12.73 years. Maximum stroke cases were seen in the age group of 41–60 years and 61–80 years of age. The most common site was basal ganglia 112 (37.83%) and common arterial involvement was MCA 161 (54.4%) with statistical significance (P < 0.05). Conclusions: The incidence of stroke rises with age and has its peak in the highly productive age group of 40–60 years of age. The findings of the present study will be helpful to young doctors for proper diagnosis and treatment.
背景:本研究是一项基于计算机断层扫描(CT)的脑卒中地形图分析,它构成了梗死和出血在不同神经解剖结构中的分布。在印度,CT扫描是一种很容易负担得起的准确诊断脑卒中的技术。目的:本研究旨在通过CT扫描评估脑血管意外患者脑卒中的发生率。受试者和方法:脑血管意外患者使用GE Revolution ACTs 16层多探测器行CT扫描仪进行头部CT扫描,扫描层厚度为2mm、5mm和10mm,矩阵大小为512×512。在2019-2021年期间,SCB医学院对20岁以上患者的中风发病率进行了评估。根据年龄、性别和动脉受累的中风亚型来研究中风的发病率。结果:脑梗死的地形图随大脑中动脉(MCA)区域的变化而变化很大。296例患者中有190例为缺血性脑卒中,106例为出血性脑卒中。平均年龄55.28±12.73岁。中风病例最多的年龄组为41-60岁和61-80岁。最常见的部位为基底节112(37.83%),总动脉受累为MCA 161(54.4%),具有统计学意义(P<0.05)。本研究的发现将有助于年轻医生进行正确的诊断和治疗。
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引用次数: 0
Immuno histological evidence of ormocarpum sennoides dc extract in the expression of bax and bcl2 in wister rats with glucocorticoid induced osteoporosis 山核桃提取物对糖皮质激素所致骨质疏松大鼠bax和bcl2表达影响的免疫组织学证据
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_19_22
Bhuvaneswari Srinivasan, R. Krishnan
Introduction: Glucocorticoid therapy is the most common cause for secondary osteoporosis leading to a resurgence of interest in traditional medicine that could have bone sparing effects by naturally occurring bioactive molecules. Therefore, this study was done to evaluate the effect of Ormocarpum sennoides DC through immunohistological evidence in the expression of Bax and Bcl2 in glucocorticoid-induced Osteoporosis in Wister albino rats. Materials and Methods: Rats were divided into five groups (Control, MPA (Osteoporosis), Alendronate (2 mg/kg), 100 mg (EOS), and 200 mg (EOS). The treatment was conducted for 45 days the Bax and Bcl2 expressions were evaluated in osteoclast of distal femur diaphysis. Results: When compared the MPA to control group (P < 0.05) Bax increased and Bcl2 reduced, when compared with MPA (P < 0.05) Alendronate, EOS 100 mg and EOS 200 mg increased the Bcl2 expressions, Alendronate, EOS 100 mg, and EOS 200 mg reduced the Bax expression. Discussion and Conclusion: EOS 100 mg and EOS 200 mg increased Bcl2 expression and reduced the Bax expression Ormocarpum sennoides prevents glucocorticoid-induced Apoptosis of preosteoblast; therefore, Bcl2 may be an important regulator of bone growth thus reporting antiapoptotic property of Ormocarpum sennoides DC.
糖皮质激素治疗是继发性骨质疏松症最常见的原因,导致人们对传统药物的兴趣重新燃起,传统药物可以通过自然发生的生物活性分子来起到保骨作用。因此,本研究通过免疫组织学证据来评价大鼠白化病糖皮质激素所致骨质疏松症大鼠体内Bax和Bcl2表达的影响。材料与方法:将大鼠分为5组(对照组、MPA(骨质疏松症)、阿仑膦酸钠(2 mg/kg)、100 mg (EOS)、200 mg (EOS))。治疗45 d后,测定股骨远端破骨细胞中Bax和Bcl2的表达。结果:与对照组比较,MPA组Bax升高(P < 0.05), Bcl2降低(P < 0.05);与MPA组比较,阿仑膦酸钠、EOS 100 mg、EOS 200 mg组Bcl2表达升高(P < 0.05),阿仑膦酸钠、EOS 100 mg、EOS 200 mg组Bax表达降低(P < 0.05)。讨论与结论:eos100 mg和eos200 mg可提高成骨前细胞Bcl2表达,降低Bax表达,抑制糖皮质激素诱导的成骨前细胞凋亡;因此,Bcl2可能是骨生长的重要调节因子,因此报道了Ormocarpum sennoides DC的抗凋亡特性。
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引用次数: 0
The stylohyoid muscle revisited: Anatomy and clinical implications 茎突舌骨肌重访:解剖学和临床意义
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_124_22
J. Lee, Soyeon Kim, Larnani Sri, M. Akira, T. Dharma, Young-Seok Park
The stylohyoid muscle, one of the four suprahyoid muscles and one of the three styloid muscles, is a small thin muscle running from the styloid process to the hyoid bone. It is intimately related to the styloid process and the styloid ligament. It draws the hyoid bone superiorly and posteriorly along with the posterior belly of the digastric muscle. It functions mainly during swallowing and opening of the mandible. Clinically, it has received much attention for its association with Eagle's syndrome. In this review, anatomic considerations with clinical implications of the stylohyoid muscle will be covered.
茎突舌骨肌是四个舌骨上肌和三个茎突肌之一,是从茎突到舌骨的小而薄的肌肉。它与茎突和茎突韧带密切相关。它沿着二腹肌的后腹向上和向后牵引舌骨。它主要在吞咽和打开下颌骨时起作用。临床上,它因与伊格尔氏综合征有关而受到广泛关注。在这篇综述中,茎突舌骨肌的解剖学考虑与临床意义将被涵盖。
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引用次数: 0
A morphological study of cadaveric liver 尸体肝脏的形态学研究
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_177_21
M. Sar, S. Singh, S. Behera, D. Bara, Jeneeta Baa, S. Mishra, A. Soy
Background: Liver is anatomically divided into right, left, quadrate, and caudate lobes. Functionally, it is divided into four portal sectors by four branches of portal vein. Three hepatic veins lie between these sectors as intersectoral veins and these intersectoral plains are called portal fissures. Minor fissures like umbilical fissure, venous fissure, and Rouviere's sulcus are visible clefts on the visceral surface of the liver. Morphological variations in size, shape, lobes, and fissures are frequently found during routine dissection. This study is focused mostly on the surgical anatomy of lobes and fissures relevant for hepatic surgery. Materials and Methods: This was a cross-sectional descriptive study conducted on 50 formalin-preserved specimens of liver. The details of morphological features of lobes and fissures were examined and compared with the findings of previous studies. Results: Out of 50 liver specimens studied, in 8% of cases left lobe and quadrate lobe and in 12% of cases caudate lobe were hypoplastic. Accessory liver lobes were found in 12% of cases, most of which were small except 2 cases of large tongue shaped projections of accessory lobes attached to the left lobe and 2 on the right lobe. Diaphragmatic sulci were found in 12% of cases and Rouviere's sulcus in 64% of cases. Accessory fissures were also found in quadrate and caudate lobes in 24% and 22% of cases, respectively. Pons hepatis was found in 20% of cases. Conclusion: Awareness about prevalence of morphological variations of liver can help avoiding errors in diagnosis and unwanted complications during surgery.
背景:肝脏在解剖学上分为右叶、左叶、方形叶和尾状叶。在功能上,它被门静脉的四个分支分为四个门静脉区。三个肝静脉位于这些部门之间,称为部门间静脉,这些部门间平原称为门静脉裂隙。小裂隙如脐裂、静脉裂、鲁维埃沟是肝脏内脏表面可见的裂隙。在常规解剖中经常发现大小、形状、裂片和裂隙的形态学变化。本研究主要集中在与肝手术相关的肝叶和肝裂的外科解剖上。材料和方法:这是一项横断面描述性研究,对50例经福尔马林保存的肝脏标本进行了研究。研究了裂片和裂隙的形态学特征,并与以往的研究结果进行了比较。结果:50例肝脏标本中,8%的左叶、方叶、12%的尾状叶发育不全。12%的病例可见副肝叶,除2例附于左叶,2例附于右叶有舌状突起外,多数为小肝叶。膈沟占12%,鲁维埃沟占64%。方形叶和尾状叶也有副裂,分别占24%和22%。20%的病例发现肝桥。结论:了解肝脏形态变异的流行情况,有助于避免手术诊断错误和不必要的并发症。
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引用次数: 0
Triorchidism: A Differential Diagnosis of Inguinal Swelling in a 28-Year-Old Male 华支睾吸虫病:28岁男性腹股沟肿胀的鉴别诊断
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_23_22
A. Nuveen
Polyorchidism, more than two testicles, is a rare congenital anomaly of urogenital system. In majority of the cases, supernumerary testis is located intrascrotally. However, testis in the retroperitoneal space is reported rarely. About 50% of cases are detected between 15 and 25 years of age. In this case report, we present a case of triorchidism in a 28-year-old male who came with a complaint of left groin swelling.
两个以上睾丸的多睾是一种罕见的先天性泌尿生殖系统异常。在大多数情况下,多余的睾丸位于睾丸内。然而,腹膜后间隙的睾丸很少被报道。大约50%的病例是在15至25岁之间发现的。在这篇病例报告中,我们报告了一例28岁男性的三宫内膜炎,他主诉左腹股沟肿胀。
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引用次数: 0
To estimate age- and gender-related morphometric change in cella media index of the lateral ventricles by computed tomography scan in adult human population of North India 通过计算机断层扫描估计北印度成年人群侧脑室cella-media指数与年龄和性别相关的形态计量学变化
IF 0.4 4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-04-01 DOI: 10.4103/jasi.jasi_97_22
J. Sharma, Pradeep Singh, Anjali Gupta, Anshu Gupta
Background and Aim: Several histopathological and gross changes are seen in human brain as age increases, causing enlargement of the lateral ventricles. Morphometric measurement and size of the lateral ventricle of the brain are of great importance to identify certain changes and correlate it with clinical significance. This study was designed to provide a normal data of the cella media index (CMI) measurements of the lateral ventricle of the brain and its association between both the genders and its correlation with different age groups of North Indian Population, which will be helpful for diagnosis of cerebral atrophy. Subjects and Methods: This study was carried out in the Department of Anatomy and Department of Radiodiagnosis, S. N. Medical College, Agra, Uttar Pradesh. In the present prospective study, computed tomography scans of 200 patients between the age of 18 and 75 years (126 males and 74 females) were done, and measurements of the lateral ventricle of the brain were analyzed statistically. Results: In our study, the overall mean CMI was 4.62 ± 0.5 (CMI in male was 4.53 ± 0.41 and mean CMI in female was 4.42 ± 0.28), difference being statistically significant between both genders as P = 0.04 (P ≤ 0.05). In our finding, r = −0.13, indicating a mild positive correlation between age and transverse diameter of CMI of the lateral ventricle in North Indian population. Conclusion: This study concludes that with increase in age, there is a decrease of cella media ratio/Schiersmann's Index, which is helpful in diagnosis of neurological conditions (e.g. schizophrenia, bipolar disorder, and Alzheimer's disease).
背景和目的:随着年龄的增长,人脑出现了一些组织病理学和大体变化,导致侧脑室增大。脑侧脑室的形态计量学测量和大小对于识别某些变化并将其与临床意义相关联具有重要意义。本研究旨在提供大脑侧脑室的cella-media指数(CMI)测量的正常数据及其性别之间的关系及其与北印度不同年龄组人群的相关性,这将有助于脑萎缩的诊断。受试者和方法:本研究在北方邦阿格拉S.N.医学院解剖系和放射诊断系进行。在本前瞻性研究中,对200名年龄在18岁至75岁之间的患者(126名男性和74名女性)进行了计算机断层扫描,并对大脑侧脑室的测量进行了统计分析。结果:在我们的研究中,总体平均CMI为4.62±0.5(男性CMI为4.53±0.41,女性CMI为4.42±0.28),男女差异具有统计学意义,P=0.04(P≤0.05)。在我们的发现中,r=−0.13,表明北印度人群的年龄与侧脑室CMI横径之间存在轻度正相关。结论:本研究得出结论,随着年龄的增长,cella-media比值/Shiersmann指数下降,这有助于神经系统疾病(如精神分裂症、双相情感障碍和阿尔茨海默病)的诊断。
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引用次数: 0
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Journal of the Anatomical Society of India
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