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Effect of surgery setting for outpatient shoulder procedures on early postoperative complications in a military population 门诊肩关节手术的手术环境对军人早期术后并发症的影响
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.04.028
Jordan G. Tropf MD , Benjamin W. Hoyt MD , Sarah Y. Nelson MD , Sarah E. Rabin MD , Christopher J. Tucker MD

Background

There has been a recent push to transition procedures previously performed at hospital-based outpatient surgical departments (HOPDs) to ambulatory surgery centers (ASCs). However, limited data regarding differences in early postoperative complications and care utilization (eg, emergency department visits and unplanned admissions) may drive increased overall costs or worse outcomes.

Purpose/Hypothesis

The purpose of this study was to examine differences in early 90-day adverse outcomes and postoperative emergency department visits associated with shoulder surgeries excluding arthroplasties that were performed in HOPDs and ASCs in a closed military health care system. We hypothesized that there would be no difference in outcomes between treatment settings.

Methods

We retrospectively evaluated the records for 1748 elective shoulder surgeries from 2015 to 2020. Patients were considered as 1 of 2 cohorts depending on whether they underwent surgery in an ASC or HOPD setting. We evaluated groups for differences incomplexity, surgical time, and medical risk. Outcome measures were emergency department visits, unplanned hospital admissions, and complications within the first 90 days after surgery.

Results

There was no difference in 90-day postoperative emergency department visits between procedures performed at HOPDs (n = 606) and ASCs (n = 1142). There was a slight increase in rate of unplanned hospital admission within 90 days after surgery in the HOPD cohort, most commonly for pain or overnight observation. The surgical time was significantly shorter (105 vs. 119 minutes, P < .01) at the ASC, but there was no difference in case complexity between the cohorts (P = .28).

Discussion/Conclusion

Our results suggest that in appropriate patients, surgery in ASCs can be safely leveraged for its costs savings, efficiency, patient satisfaction, decreases in operative time, and potentially decreased resource utilization both during surgery and in the early postoperative period.
背景:最近,人们开始推动将以前在医院门诊手术部(HOPD)进行的手术过渡到非卧床手术中心(ASC)。然而,有关术后早期并发症和护理利用率(如急诊就诊和计划外入院)差异的数据有限,这可能会导致总体成本增加或治疗效果变差:/假设:本研究旨在探讨在封闭的军事医疗系统中,除关节置换手术外,在HOPD和ASC进行的肩关节手术在90天早期不良后果和术后急诊就诊率方面的差异。我们假设不同治疗环境下的结果没有差异:我们回顾性评估了 2015 年至 2020 年期间 1748 例选择性肩关节手术的记录。根据患者是在 ASC 还是 HOPD 环境中接受手术,将其视为两个组群之一。我们对各组的不复杂性、手术时间和医疗风险进行了评估。衡量结果的指标包括急诊就诊率、非计划住院率以及术后 90 天内的并发症:在 HOPD(n = 606)和 ASC(n = 1142)进行的手术在术后 90 天的急诊就诊率上没有差异。HOPD队列中术后90天内的非计划入院率略有增加,最常见的原因是疼痛或过夜观察。手术时间明显缩短(105 分钟对 119 分钟,P 讨论/结论:我们的研究结果表明,对于合适的患者,可以安全地利用 ASC 手术来节约成本、提高效率、提高患者满意度、缩短手术时间,并在手术期间和术后早期降低资源利用率。
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引用次数: 0
A transitional pain management program is associated with reduced opioid dependence after major shoulder surgery 肩部大手术后,过渡性疼痛管理计划可降低阿片类药物依赖性。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.005
Oliver Sroka MD , Joseph Featherall MD , Kimberlee Bayless DNP , Zachary Anderson PharmD , Adrik Da Silva BS , Benjamin S. Brooke MD, PhD , Michael J. Buys MD , Peter N. Chalmers MD , Robert Z. Tashjian MD

Background

Overprescription of opioids in the United States increases risks of opioid dependence, overdose, and death. Increased perioperative and postoperative opioid use during orthopedic shoulder surgery is a significant risk factor for long-term opioid dependence. The authors hypothesized that a multidisciplinary perioperative pain management program (Transitional Pain Service [TPS]) for major shoulder surgery would lead to a reduced amount of opioids required postoperatively.

Methods

A TPS was implemented at a Veterans Affairs Medical Center focused on nonopioid pain management and cessation support. Opioid consumption during the implementation of the TPS was compared to a historical cohort. All patients undergoing total shoulder arthroplasty (TSA) or rotator cuff repair (RCR) were included. The primary outcome was the proportion of patients continuing opioid use at 90 days postoperatively. Secondary outcomes included postoperative pain scores, time to opioid cessation, and median opioid tablets consumed at 90 days. A multivariable model was developed to predict total opioid use at 90 days postoperatively. Kaplan-Meier curves were calculated for time to opioid cessation.

Results

The TPS group demonstrated decreased persistent opioid use at 90 days postdischarge (12.6% vs. 28.6%; P = .018). Independent predictors associated with increased total opioid tablet prescriptions at 90 days included length of stay (β = 19.17), anxiety diagnosis (β = 37.627), and number of tablets prescribed at discharge (β = 1.353). TSA was associated with decreased 90-day opioid utilization (β = –32.535) when compared to RCR. Median time to cessation was shorter in TSA (6 days) when compared with RCR (8 days). Pain scores were reduced compared with population mean by postdischarge day 2 for TSA and by postdischarge day 7 for RCR. Median number of postdischarge opioid tablets (oxycodone 5 mg) consumed under TPS management was 25 in both RCR and TSA surgery groups (180 morphine milligram equivalents).

Discussion and Conclusions

This study demonstrates that a TPS reduces the amount of opioid use of patients undergoing shoulder arthroplasty or cuff repair at 90 days when compared with a historical control. Multivariable regression indicated that fewer opioid tablets at discharge was a modifiable factor that may aid in reducing opioid consumption and that anxiety diagnosis, increased length of stay, and cuff repair surgery were other factors independently associated with increased opioid consumption. These data will assist surgeons in counseling patients, setting narcotic use expectations, and minimizing overprescribing. Use of a similar multidisciplinary perioperative pain management program may greatly reduce opioid overprescriptions nationally.
背景:在美国,阿片类药物的过量处方增加了阿片类药物依赖、用药过量和死亡的风险。肩部骨科手术围手术期和术后阿片类药物使用量的增加是导致长期阿片类药物依赖的一个重要风险因素。作者假设,针对肩部大手术的多学科围手术期疼痛管理计划(过渡性疼痛服务或 TPS)将减少术后阿片类药物的用量:方法:退伍军人事务医疗中心实施了一项 TPS 计划,重点是非阿片类药物疼痛管理和停药支持。将实施 TPS 期间的阿片类药物消耗量与历史队列进行比较。所有接受肩关节置换术或肩袖修复术的患者都包括在内。主要结果是术后 90 天内继续使用阿片类药物的患者比例。次要结果包括术后疼痛评分、停止使用阿片类药物的时间以及 90 天内阿片类药物用量的中位数。我们建立了一个多变量模型来预测术后 90 天的阿片类药物总用量。计算了停止使用阿片类药物时间的卡普兰-梅耶曲线:结果:TPS组在出院后90天持续使用阿片类药物的情况有所减少(12.6%对28.6%;P=0.018)。与 90 天内阿片类药物总处方量增加相关的独立预测因素包括住院时间(β=19.17)、焦虑诊断(β=37.627)和出院时处方的药片数量(β=1.353)。与肩袖修复术(RCR)相比,肩关节置换术(TSA)减少了阿片类药物的90天使用量(β=-32.535)。与 RCR(8 天)相比,TSA 停止使用阿片类药物的中位时间更短(6 天)。TSA患者出院后第2天的疼痛评分低于人群平均值,RCR患者出院后第7天的疼痛评分低于人群平均值。在TPS管理下,RCR和TSA手术组出院后阿片类药片(羟考酮5毫克)的中位数均为25片(180 MME):本研究表明,与历史对照组相比,TPS可减少肩关节置换术或肩袖修复术患者在90天内的阿片类药物用量。多变量回归表明,出院时阿片类药物片剂较少是有助于减少阿片类药物用量的一个可调节因素,而焦虑诊断、住院时间延长和肩袖修复手术是与阿片类药物用量增加独立相关的其他因素。这些数据将有助于外科医生为患者提供咨询、设定麻醉剂使用预期并尽量减少过度处方。采用类似的多学科围手术期疼痛管理计划可能会大大减少全国范围内的阿片类药物超量处方。
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引用次数: 0
How fellowship training affects complication rate after shoulder arthroplasty: a nationwide assessment 研究员培训如何影响肩关节置换术后的并发症发生率:全国性评估
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.014
William E. Harkin MD, Rodrigo Saad Berreta BA, Amr Turkmani BS, Tyler Williams BS, John P. Scanaliato MD, Johnathon R. McCormick MD, Gregory P. Nicholson MD, Grant E. Garrigues MD

Background

Total shoulder arthroplasty is performed by orthopedic surgeons with various fellowship training backgrounds. Whether surgeons performing shoulder arthroplasty with different types of fellowship training have differing rates of complications and reoperation remains unknown.

Methods

The PearlDiver Mariner database was retrospectively queried from the years 2010 to 2022. Patients undergoing shoulder arthroplasty were selected using the CPT code 23472. Those undergoing revision arthroplasty and those with a history of fracture, infection, or malignancy were excluded. Fellowship was determined and verified via online search. Only surgeons who performed a minimum of 10 cases were selected; and PearlDiver was queried using their provider ID codes. Primary outcome measures included 90-day, 1-year, and 5-year rates of complication and reoperation. A Bonferroni correction was utilized in which the significance threshold was set at P ≤ .00023.

Results

In total, 150,385 patients met the inclusion criteria and were included in the study. Analysis of surgical trends revealed that Sports Medicine and Shoulder and Elbow fellowship-trained surgeons are performing an increasing percentage of all shoulder arthroplasty over time, with each cohort exhibiting an 11.3% and 4.2% increase from 2010 to 2022, respectively. The geographic region with the highest proportion of cases performed by Sports Medicine surgeons was the West, while the Northeast has the highest proportion of cases performed by Shoulder and Elbow surgeons. Shoulder and Elbow surgeons operated on patients that were significantly younger and had fewer comorbidities. Both Shoulder and Elbow and Sports Medicine surgeons had lower rates of postoperative complications at 90 days, 1 year, and 5 years in comparison to surgeons who completed another type of fellowship or no fellowship. Across each time point, the rates of individual complications between Sports Medicine and Shoulder and Elbow were comparable, but the pooled complication rate was lowest in the Shoulder and Elbow cohort.

Conclusion

Surgeons who have completed either a Sports Medicine or Shoulder and Elbow fellowship are performing an increasing proportion of shoulder arthroplasty over time. Sports Medicine and Shoulder and Elbow-trained surgeons have significantly lower complication rates at 90 days, 1 year, and 5 years postoperatively. The individual complication rates between Sports Medicine and Shoulder and Elbow are comparable, but Shoulder and Elbow have the lowest pooled complication rates overall.
背景:全肩关节置换术由具有不同研究培训背景的骨科医生实施。接受过不同类型研究培训的外科医生在进行肩关节置换术时是否会出现不同的并发症和再手术率,目前仍是未知数:方法:我们回顾性查询了 2010-2022 年间的 PearlDiver Mariner 数据库。使用 CPT 编码 23472 挑选了接受肩关节置换术的患者。排除了接受翻修关节置换术的患者以及有骨折、感染或恶性肿瘤病史的患者。研究员资格通过在线搜索确定和验证。仅选择至少完成 10 例手术的外科医生;并使用其提供者 ID 代码查询 PearlDiver。主要结果指标包括 90 天、1 年和 5 年的并发症发生率和再手术率。结果:共有 150,385 名患者符合纳入标准并被纳入研究。对手术趋势的分析表明,运动医学和肩肘研究员培训外科医生在所有肩关节置换术中所占的比例随着时间的推移在不断增加,从2010年到2022年,每个队列分别增加了11.3%和4.2%。由运动医学外科医生实施的病例比例最高的地区是西部,而由肩肘外科医生实施的病例比例最高的地区是东北部。肩肘外科医生手术的患者明显更年轻,合并症也更少。肩肘外科医生和运动医学外科医生在 90 天、1 年和 5 年后的术后并发症发生率均低于完成其他类型研究或未完成研究的外科医生。在每个时间点上,运动医学科与肩肘外科的单个并发症发生率相当,但肩肘外科的综合并发症发生率最低:结论:随着时间的推移,完成运动医学或肩肘研究金课程的外科医生进行肩关节置换术的比例越来越高。接受过运动医学和肩肘培训的外科医生在术后 90 天、1 年和 5 年的并发症发生率明显较低。运动医学科和肩肘外科的单个并发症发生率相当,但肩肘外科的总体并发症发生率最低。
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引用次数: 0
Anatomic total shoulder arthroplasty for posteriorly eccentric and concentric osteoarthritis: a comparison at a minimum 5-year follow-up 针对后偏心型和同心型骨关节炎的解剖型全肩关节置换术:至少 5 年随访的比较。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.04.026
Mihir M. Sheth MD, Zachary D. Mills MD, Suhas P. Dasari MD, Anastasia J. Whitson BSPH, Frederick A. Matsen III MD, Jason E. Hsu MD

Background

In patients with glenohumeral osteoarthritis and posteriorly eccentric wear patterns, the early to midterm results of total shoulder arthroplasty (TSA) using conservative glenoid reaming with no attempt at version correction have been favorable at early follow-up. The purpose of this study is to compare the clinical and radiographic outcomes of TSA using this technique for patients with and without eccentric wear patterns at a minimum 5-year follow-up.

Methods

Patients who underwent TSA with minimum 5-year follow-up were identified from an institutional registry. Preoperative and postoperative radiographs were used to determine humeroglenoid alignment (HGA-AP), humeroscapular alignment (HSA-AP), version, Walch classification, and glenoid component seating. The outcome measures were the Simple Shoulder Test (SST), glenoid component radiolucencies, and the occurrence of complications or revisions.

Results

Two hundred ten patients were included in the study, of which 98 (47%) had posteriorly decentered humeral heads and 108 (51%) had centered humeral heads. There were 77 shoulders with Walch type A glenoids and 122 with Walch type B glenoids. At a mean 8-year follow-up, the final SST score, change in SST score, and percentage of maximal improvement was not correlated with pre- and postoperative humeral head centering, Walch classification, or glenoid version. There were no preoperative predictors of a low final SST score. Two patients (1%) underwent open reoperations during the study period. In patients with Walch B1 and B2 glenoids (n = 110), there were no differences in outcome measures between patients with postoperative retroversion of more and less than 15°. Although 15 of 51 patients (29%) with minimum 5-year radiographs had glenoid radioluciences, these radiographic findings were not associated with inferior clinical outcomes. On multivariable analysis, glenoid component radiolucencies were most strongly associated with incomplete component seating (OR 3.3, P = .082).

Conclusion

The results of TSA with conservative glenoid reaming without attempt at version correction are favorable at a minimum 5-year, and mean 8-year, follow-up. There were no differences in clinical and radiographic outcomes between patients with eccentric and concentric wear patterns. Incomplete glenoid component seating was the greatest predictor of glenoid component radiolucency, but these radiolucencies were not associated with inferior clinical outcomes.
背景:对于患有盂肱骨关节炎和后侧偏心磨损模式的患者,在早期随访时,采用保守的盂成形术进行TSA,且不试图进行版本矫正,其早期和中期效果良好。本研究的目的是比较使用该技术对有和无偏心磨损模式的患者进行TSA至少5年随访的临床和影像学结果:方法:从机构登记册中筛选出至少随访 5 年的 TSA 患者。术前和术后X光片用于确定肱骨盂对齐(HGA-AP)、肱骨肩胛对齐(HSA-AP)、版本、Walch分类和盂部件就位。结果测量指标为简单肩关节测试、盂部件桡骨影、并发症发生率或翻修率:研究共纳入210名患者,其中98人(47%)的肱骨头后方偏位,108人(51%)的肱骨头居中。77个肩关节使用了Walch A型关节镜,122个使用了Walch B型关节镜。在平均8年的随访中,最终的SST、SST的变化和最大改善的百分比与术前和术后的肱骨头居中情况、Walch分类或盂型无关。术前没有预测最终SST偏低的因素。研究期间,有两名患者(1%)接受了开放性再手术。在Walch B1和B2盂成形术患者中(n=110),术后后凸度大于或小于15o的患者在结果测量上没有差异。虽然51名患者中有15名(29%)在最短5年的影像学检查中发现了盂状放射,但这些影像学结果与较差的临床结果无关。多变量分析显示,髋臼组件桡骨突出与组件未完全就位关系最大(OR 3.3,P = 0.082):结论:在保守的盂成形术基础上进行TSA,而不试图进行畸形矫正,在最少5年、平均8年的随访中效果良好。偏心和同心磨损模式患者的临床和影像学结果没有差异。髋臼组件未完全就位是髋臼组件出现放射性白斑的最大预测因素,但这些放射性白斑与较差的临床结果无关。
{"title":"Anatomic total shoulder arthroplasty for posteriorly eccentric and concentric osteoarthritis: a comparison at a minimum 5-year follow-up","authors":"Mihir M. Sheth MD,&nbsp;Zachary D. Mills MD,&nbsp;Suhas P. Dasari MD,&nbsp;Anastasia J. Whitson BSPH,&nbsp;Frederick A. Matsen III MD,&nbsp;Jason E. Hsu MD","doi":"10.1016/j.jse.2024.04.026","DOIUrl":"10.1016/j.jse.2024.04.026","url":null,"abstract":"<div><h3>Background</h3><div>In patients with glenohumeral osteoarthritis and posteriorly eccentric wear patterns, the early to midterm results of total shoulder arthroplasty (TSA) using conservative glenoid reaming with no attempt at version correction have been favorable at early follow-up. The purpose of this study is to compare the clinical and radiographic outcomes of TSA using this technique for patients with and without eccentric wear patterns at a minimum 5-year follow-up.</div></div><div><h3>Methods</h3><div>Patients who underwent TSA with minimum 5-year follow-up were identified from an institutional registry. Preoperative and postoperative radiographs were used to determine humeroglenoid alignment (HGA-AP), humeroscapular alignment (HSA-AP), version, Walch classification, and glenoid component seating. The outcome measures were the Simple Shoulder Test (SST), glenoid component radiolucencies, and the occurrence of complications or revisions.</div></div><div><h3>Results</h3><div>Two hundred ten patients were included in the study, of which 98 (47%) had posteriorly decentered humeral heads and 108 (51%) had centered humeral heads. There were 77 shoulders with Walch type A glenoids and 122 with Walch type B glenoids. At a mean 8-year follow-up, the final SST score, change in SST score, and percentage of maximal improvement was not correlated with pre- and postoperative humeral head centering, Walch classification, or glenoid version. There were no preoperative predictors of a low final SST score. Two patients (1%) underwent open reoperations during the study period. In patients with Walch B1 and B2 glenoids (n = 110), there were no differences in outcome measures between patients with postoperative retroversion of more and less than 15°. Although 15 of 51 patients (29%) with minimum 5-year radiographs had glenoid radioluciences, these radiographic findings were not associated with inferior clinical outcomes. On multivariable analysis, glenoid component radiolucencies were most strongly associated with incomplete component seating (OR 3.3, <em>P</em> = .082).</div></div><div><h3>Conclusion</h3><div>The results of TSA with conservative glenoid reaming without attempt at version correction are favorable at a minimum 5-year, and mean 8-year, follow-up. There were no differences in clinical and radiographic outcomes between patients with eccentric and concentric wear patterns. Incomplete glenoid component seating was the greatest predictor of glenoid component radiolucency, but these radiolucencies were not associated with inferior clinical outcomes.</div></div>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"34 2","pages":"Pages 473-483"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glenoid structural bone grafting in reverse total shoulder arthroplasty: clinical and radiographic outcomes 反向全肩关节置换术中的盂状结构骨移植:临床和影像学结果
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.008
Connor Sholtis MD, Stephanie T. Kha MD, Anna Ramakrishnan MS, Geoffrey D. Abrams MD, Michael T. Freehill MD, Emilie V. Cheung MD
<div><h3>Background</h3><div>Current options for reconstruction of large glenoid defects in reverse total shoulder arthroplasty (RTSA) include structural bone grafting, use of augmented components, or 3D-printed custom implants. Given the paucity in the literature on structural bone grafts in RTSA, this study reflects our experience on clinical and radiographic outcomes of structural bone grafts used for glenoid defects in RTSA.</div></div><div><h3>Methods</h3><div>We identified 33 consecutive patients who underwent RTSA using structural bone grafts for glenoid bone loss between 2008 and 2019. Twenty-six patients with a mean clinical follow-up of 4.4 ± 3.9 years and a mean radiographic follow-up of 2.7 ± 3.2 years were included. Patient demographic data, perioperative functional outcomes, radiographic outcomes, complications, and reoperation rates were determined.</div></div><div><h3>Results</h3><div>Between 2008 and 2019, 26 RTSAs were performed using structural autograft or allograft for glenoid defects. There were 20 females (77%) and 6 males (23%), with a mean presenting age of 68 years (range 41-86), mean BMI of 29 (range 21-44), and mean Charlson Comorbidity Index of 3 (range 0-8). There were 19 cases of central glenoid defects, and 7 were combined central and peripheral defects. Structural grafts included humeral head autograft (7), proximal humerus autograft (7), iliac crest autograft (7), distal clavicle autograft (2), and femoral head allograft (3). All 18 revision RTSA cases had simultaneous humeral-sided revision. There was significant postoperative improvement in American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form scores (27.0 ± 12.6 preoperation vs. 59.8 ± 24.1 postoperation; <em>P</em> < .001) and visual analog scale scores (8.1 ± 3.6 preoperation vs. 3.0 ± 3.2 postoperation; <em>P</em> < .001). Range of motion improved significantly for active forward elevation (63° ± 36° preoperation vs. 104° ± 36° postoperation; <em>P</em> < .001) and external rotation (21° ± 20° preoperation vs. 32° ± 23° postoperation, <em>P</em> = .036). Eighty-eight percent of cases (23 of 26) had successful reconstruction of the glenoid, defined as no visible radiolucent lines nor glenoid component migration at final follow-up. The reoperation rate was 19% (5 of 26). Postoperative complications included 2 cases of acromial stress fractures that were treated nonoperatively, for a total complication rate (including reoperation) of 27% (7 of 26 cases).</div></div><div><h3>Conclusions</h3><div>The use of structural bone autografts and allografts in RTSA was associated with improved outcome scores and range of motion. A reoperation rate of 19% and total complication rate of 27% were reported for these challenging cases. However, 86% of these complications were not related to structural glenoid reconstruction failure. Structural grafts are a reasonable option for glenoid reconstruction in RTSA cases with glenoid bone loss.</div></d
导言:在反向全肩关节置换术(RTSA)中,重建大面积盂缺损的现有方案包括结构性骨移植、使用增强组件或3D打印定制植入物。鉴于有关反向全肩关节置换术中结构性骨移植的文献较少,本研究反映了我们在反向全肩关节置换术中利用结构性骨移植治疗盂缺损的临床和影像学结果:我们确定了 33 名在 2008 年至 2019 年期间因盂骨缺损而接受 RTSA 并使用结构性植骨的连续患者。26例患者的平均临床随访时间为(4.4 ± 3.9)年,平均影像学随访时间为(2.7 ± 3.2)年。确定了患者的人口统计学数据、围手术期功能结果、放射学结果、并发症和再手术率:2008年至2019年期间,共进行了26例RTSAs手术,利用结构性自体或异体移植物治疗盂缺损。其中女性20例(77%),男性6例(23%),平均发病年龄68岁(41-86岁),平均体重指数29(21-44岁),平均Charlson综合指数3(0-8岁)。其中19例为中央型盂缺损,7例为中央型和外周型联合缺损。结构性移植物包括肱骨头自体移植物(7 例)、肱骨近端自体移植物(7 例)、髂嵴自体移植物(7 例)、锁骨远端自体移植物(2 例)和股骨头同种异体移植物(3 例)。所有18例RTSA翻修病例都同时进行了肱骨侧翻修。术后ASES评分有明显改善(术前27.0 ± 12.6 vs. 术后59.8 ± 24.1; p结论:在RTSA中使用结构性骨自体和异体移植与结果评分和活动范围的改善有关。据报道,在这些具有挑战性的病例中,再次手术率为 19%,总并发症率为 27%。然而,86%的并发症与结构性盂重建失败无关。对于盂骨缺失的 RTSA 病例,结构性移植物是盂骨重建的合理选择。
{"title":"Glenoid structural bone grafting in reverse total shoulder arthroplasty: clinical and radiographic outcomes","authors":"Connor Sholtis MD,&nbsp;Stephanie T. Kha MD,&nbsp;Anna Ramakrishnan MS,&nbsp;Geoffrey D. Abrams MD,&nbsp;Michael T. Freehill MD,&nbsp;Emilie V. Cheung MD","doi":"10.1016/j.jse.2024.05.008","DOIUrl":"10.1016/j.jse.2024.05.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Current options for reconstruction of large glenoid defects in reverse total shoulder arthroplasty (RTSA) include structural bone grafting, use of augmented components, or 3D-printed custom implants. Given the paucity in the literature on structural bone grafts in RTSA, this study reflects our experience on clinical and radiographic outcomes of structural bone grafts used for glenoid defects in RTSA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We identified 33 consecutive patients who underwent RTSA using structural bone grafts for glenoid bone loss between 2008 and 2019. Twenty-six patients with a mean clinical follow-up of 4.4 ± 3.9 years and a mean radiographic follow-up of 2.7 ± 3.2 years were included. Patient demographic data, perioperative functional outcomes, radiographic outcomes, complications, and reoperation rates were determined.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Between 2008 and 2019, 26 RTSAs were performed using structural autograft or allograft for glenoid defects. There were 20 females (77%) and 6 males (23%), with a mean presenting age of 68 years (range 41-86), mean BMI of 29 (range 21-44), and mean Charlson Comorbidity Index of 3 (range 0-8). There were 19 cases of central glenoid defects, and 7 were combined central and peripheral defects. Structural grafts included humeral head autograft (7), proximal humerus autograft (7), iliac crest autograft (7), distal clavicle autograft (2), and femoral head allograft (3). All 18 revision RTSA cases had simultaneous humeral-sided revision. There was significant postoperative improvement in American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form scores (27.0 ± 12.6 preoperation vs. 59.8 ± 24.1 postoperation; &lt;em&gt;P&lt;/em&gt; &lt; .001) and visual analog scale scores (8.1 ± 3.6 preoperation vs. 3.0 ± 3.2 postoperation; &lt;em&gt;P&lt;/em&gt; &lt; .001). Range of motion improved significantly for active forward elevation (63° ± 36° preoperation vs. 104° ± 36° postoperation; &lt;em&gt;P&lt;/em&gt; &lt; .001) and external rotation (21° ± 20° preoperation vs. 32° ± 23° postoperation, &lt;em&gt;P&lt;/em&gt; = .036). Eighty-eight percent of cases (23 of 26) had successful reconstruction of the glenoid, defined as no visible radiolucent lines nor glenoid component migration at final follow-up. The reoperation rate was 19% (5 of 26). Postoperative complications included 2 cases of acromial stress fractures that were treated nonoperatively, for a total complication rate (including reoperation) of 27% (7 of 26 cases).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;The use of structural bone autografts and allografts in RTSA was associated with improved outcome scores and range of motion. A reoperation rate of 19% and total complication rate of 27% were reported for these challenging cases. However, 86% of these complications were not related to structural glenoid reconstruction failure. Structural grafts are a reasonable option for glenoid reconstruction in RTSA cases with glenoid bone loss.&lt;/div&gt;&lt;/d","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"34 2","pages":"Pages e103-e111"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative revision, complication and economic outcomes of patients with reverse or anatomic total shoulder arthroplasty at one year: a retrospective, United States hospital billing database analysis 反向或解剖型全肩关节置换术患者术后一年的翻修、并发症和经济效益:美国医院账单数据库回顾性分析。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.009
Katherine A. Corso MPH , Caroline E. Smith BS , Mari F. Vanderkarr BS , Ronita Debnath BTech , Laura J. Goldstein MPH, JD, BA , Biju Varughese RPh, MBA , James Wood MD , Peter N. Chalmers MD , Matthew Putnam MD
<div><h3>Background</h3><div>Data on the 1-year postoperative revision, complication, and economic outcomes in a hospital setting after total shoulder arthroplasty (TSA) are sparse.</div></div><div><h3>Methods</h3><div>A retrospective cohort study using the Premier Healthcare Database, a hospital-billing data source, evaluated 1-year postoperative revision, complication, and economic outcomes of reverse (RTSA) and anatomic (ATSA) TSA for patients who underwent the procedure from 2015 until 2021. All-cause revisits, including revision-related events (categorized as either irrigation and débridement or revision procedures and device removals) and shoulder/nonshoulder complications were collected. The incidences and costs of these revisits were evaluated. Generalized linear models were used to evaluate the associations between patient characteristics and revision and complication occurrences and costs.</div></div><div><h3>Results</h3><div>Among 51,478 RTSA and 34,623 ATSA patients (mean [standard deviation] ages RTSA 71.5 [8.1] years, ATSA 66.8 [9.0] years), 1-year adjusted incidences of all-cause revisits, irrigation/débridement, revision procedures/device removals, and shoulder/nonshoulder complications were RTSA: 45.0% (95% confidence interval (CI): 44.6%-45.5%), 0.1% (95% CI: 0.1%-0.2%), 2.1% (95% CI: 2.0%-2.2%), and 17.8% (95% CI: 17.5%-18.1%) and ATSA: 42.3% (95% CI: 41.8%-42.9%), 0.2% (95% CI: 0.1%-0.2%), 1.9% (95% CI: 1.8%-2.1%), and 14.4% (95% CI: 14.0%-14.8%), respectively; shoulder-related complications were RTSA: 12.4% (95% CI: 12.1%-12.7%) and ATSA: 9.9% (95% CI: 9.6%-10.3%). Significant factors associated with a high risk of revisions and complications included, but were not limited to, chronic comorbidities and noncommercial insurance. Per patient, the mean (standard deviations) total 1-year hospital cost was $25,225 ($15,911) and $21,520 ($13,531) for RTSA and ATSA, respectively. Revision procedures and device removals were most costly, averaging $22,920 ($18,652) and $26,911 ($18,619) per procedure for RTSA and ATSA, respectively. Patients with revision-related events with infections had higher total hospital costs than patients without this event (RTSA: $60,887 (95% CI: $56,951-$64,823) and ATSA: $59,478 (95% CI: $52,312-$66,644)), equating to a mean difference of $36,148 with RTSA and $38,426 with ATSA. Significant factors associated with higher costs of revision-related events and complications included age, race, chronic comorbidities, and noncommercial insurance.</div></div><div><h3>Conclusions</h3><div>Nearly 45% RTSA and 42% ATSA patients returned to the hospital, most often for shoulder/nonshoulder complications (overall 17.8% RTSA and 14.4% ATSA, and shoulder-related 12.4% RTSA and 9.9% ATSA). Revisions and device removals were most expensive ($22,920 RTSA and $26,911 ATSA). Infection complications requiring revision had the highest 1-year hospital costs (∼$60,000). This study highlights the need for technologies and surgic
背景:关于全肩关节置换术(TSA)术后一年的翻修、并发症和经济效益的数据非常少:有关全肩关节置换术(TSA)术后一年在医院环境中的翻修、并发症和经济效益的数据很少:一项回顾性队列研究利用医院账单数据源 Premier Healthcare 数据库,对 2015 年至 2021 年期间接受反向(RTSA)和解剖(ATSA)TSA 手术的患者术后一年的翻修、并发症和经济效益进行了评估。收集了所有原因的复诊情况,包括翻修相关事件(分为冲洗和清创或翻修手术和器械取出)以及肩部/非肩部并发症。对这些复诊的发生率和费用进行了评估。采用广义线性模型评估患者特征与翻修、并发症发生率和费用之间的关系:在51,478名RTSA和34,623名ATSA患者(平均[标准差(SD)]年龄RTSA 71.5 [8.1]岁,ATSA 66.8 [9.0]岁)中,一年调整后的全因复诊、灌洗/冲洗、翻修手术/器械取出以及肩部/非肩部并发症的发生率分别为RTSA:45.0%(95%置信区间(CI):44.6%-45.5%)、0.1%(95% 置信区间:0.1%-0.2%)、2.1%(95% 置信区间:2.0%-2.2%)和 17.8%(95% 置信区间:17.5%-18.1%);ATSA:42.3%(95% 置信区间:41.8%-42.9%)、0.2%(95% 置信区间:0.1%-0.2%)、1.9%(95% CI:1.8%-2.1%)和14.4%(95% CI:14.0%-14.8%);肩部相关并发症分别为RTSA:12.4%(95% CI:12.1%-12.7%)和ATSA:9.9%(95% CI:9.6%-10.3%)。与翻修和并发症高风险相关的重要因素包括但不限于慢性合并症和非商业保险。就每位患者而言,RTSA 和 ATSA 一年的平均住院总费用(标清)分别为 25,225 美元(15,911 美元)和 21,520 美元(13,531 美元)。翻修手术和取出设备的费用最高,RTSA 和 ATSA 平均每次手术费用分别为 22,920 美元(18,652 美元)和 26,911 美元(18,619 美元)。与未发生感染的患者相比,发生翻修相关事件的患者的住院总费用更高(RTSA:60,887 美元(95% CI:56,951-64,823 美元),ATSA:59,478 美元(95% CI:52,312-66,644 美元)),相当于 RTSA 平均差异为 36,148 美元,ATSA 平均差异为 38,426 美元。与翻修相关事件和并发症费用较高相关的重要因素包括年龄、种族、慢性并发症和非商业保险:近45%的RTSA和42%的ATSA患者重返医院,最常见的原因是肩部/非肩部并发症(总体而言,RTSA为17.8%,ATSA为14.4%;与肩部相关的RTSA为12.4%,ATSA为9.9%)。翻修和移除装置的费用最高(RTSA 为 22,920 美元,ATSA 为 26,911 美元)。需要翻修的感染并发症的一年住院费用最高(∼60,000 美元)。这项研究强调了对有助于减少 TSA 医疗使用和经济负担的技术和手术技巧的需求。
{"title":"Postoperative revision, complication and economic outcomes of patients with reverse or anatomic total shoulder arthroplasty at one year: a retrospective, United States hospital billing database analysis","authors":"Katherine A. Corso MPH ,&nbsp;Caroline E. Smith BS ,&nbsp;Mari F. Vanderkarr BS ,&nbsp;Ronita Debnath BTech ,&nbsp;Laura J. Goldstein MPH, JD, BA ,&nbsp;Biju Varughese RPh, MBA ,&nbsp;James Wood MD ,&nbsp;Peter N. Chalmers MD ,&nbsp;Matthew Putnam MD","doi":"10.1016/j.jse.2024.05.009","DOIUrl":"10.1016/j.jse.2024.05.009","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Data on the 1-year postoperative revision, complication, and economic outcomes in a hospital setting after total shoulder arthroplasty (TSA) are sparse.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective cohort study using the Premier Healthcare Database, a hospital-billing data source, evaluated 1-year postoperative revision, complication, and economic outcomes of reverse (RTSA) and anatomic (ATSA) TSA for patients who underwent the procedure from 2015 until 2021. All-cause revisits, including revision-related events (categorized as either irrigation and débridement or revision procedures and device removals) and shoulder/nonshoulder complications were collected. The incidences and costs of these revisits were evaluated. Generalized linear models were used to evaluate the associations between patient characteristics and revision and complication occurrences and costs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among 51,478 RTSA and 34,623 ATSA patients (mean [standard deviation] ages RTSA 71.5 [8.1] years, ATSA 66.8 [9.0] years), 1-year adjusted incidences of all-cause revisits, irrigation/débridement, revision procedures/device removals, and shoulder/nonshoulder complications were RTSA: 45.0% (95% confidence interval (CI): 44.6%-45.5%), 0.1% (95% CI: 0.1%-0.2%), 2.1% (95% CI: 2.0%-2.2%), and 17.8% (95% CI: 17.5%-18.1%) and ATSA: 42.3% (95% CI: 41.8%-42.9%), 0.2% (95% CI: 0.1%-0.2%), 1.9% (95% CI: 1.8%-2.1%), and 14.4% (95% CI: 14.0%-14.8%), respectively; shoulder-related complications were RTSA: 12.4% (95% CI: 12.1%-12.7%) and ATSA: 9.9% (95% CI: 9.6%-10.3%). Significant factors associated with a high risk of revisions and complications included, but were not limited to, chronic comorbidities and noncommercial insurance. Per patient, the mean (standard deviations) total 1-year hospital cost was $25,225 ($15,911) and $21,520 ($13,531) for RTSA and ATSA, respectively. Revision procedures and device removals were most costly, averaging $22,920 ($18,652) and $26,911 ($18,619) per procedure for RTSA and ATSA, respectively. Patients with revision-related events with infections had higher total hospital costs than patients without this event (RTSA: $60,887 (95% CI: $56,951-$64,823) and ATSA: $59,478 (95% CI: $52,312-$66,644)), equating to a mean difference of $36,148 with RTSA and $38,426 with ATSA. Significant factors associated with higher costs of revision-related events and complications included age, race, chronic comorbidities, and noncommercial insurance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Nearly 45% RTSA and 42% ATSA patients returned to the hospital, most often for shoulder/nonshoulder complications (overall 17.8% RTSA and 14.4% ATSA, and shoulder-related 12.4% RTSA and 9.9% ATSA). Revisions and device removals were most expensive ($22,920 RTSA and $26,911 ATSA). Infection complications requiring revision had the highest 1-year hospital costs (∼$60,000). This study highlights the need for technologies and surgic","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"34 2","pages":"Pages e59-e71"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical results and computed tomography analysis of intuitive shoulder arthroplasty (ISA) stemless at a minimum follow-up of 2 years 至少随访 2 年的 ISA 无茎手术临床结果和 CT 分析。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.04.012
Cerise Gosselin MD , Yves Lefebvre MD , Thierry Joudet MD , Arnaud Godeneche MD , Johannes Barth MD , Jérome Garret MD , Stéphane Audebert MD , Christophe Charousset MD , Shoulder Friends Institute , Nicolas Bonnevialle MD, PhD

Background

The utilization of stemless anatomic total shoulder arthroplasty is on the rise. Epiphyseal fixation leads to radiological bone remodeling, which has been reported to exceed 40% in certain studies series. The aim of this study was to present the clinical and radiological outcomes of a stemless implant with asymmetric central epiphyseal fixation at an average follow-up of 31 months.

Materials and methods

This retrospective multicenter study examined prospective data of patients undergoing total anatomic arthroplasty with intuitive shoulder arthroplasty Stemless implant and followed up at least 2 years. Clinical assessment included preoperative and final follow-up measurements of active range of motion, Constant score, and Subjective Shoulder Value. Anatomical epiphyseal reconstruction and bone remodeling at the 2-year follow-up were assessed by standardized computed tomography scanner (CT scan). Statistical analysis employed unpaired Student's t-test or chi-squared test depending on the variable type, conducted using EasyMedStat software (version 3.22; www.easymedstat.com).

Results

Fifty patients (mean age 68 years, 62% females) were enrolled, with an average follow-up of 31 months (24-44). Primary osteoarthritis (68%) with type A glenoid (78%) was the prevailing indication. The mean Constant score and Subjective Shoulder Value improved significantly from 38 ± 11 to 76 ± 11 (P < .001) and from 31% ± 16 to 88% ± 15 (P < .001) respectively at the last follow-up. Forward elevation, external rotation, and internal rotation range of motion increased by 39° ± 42, 28° ± 21 and 3,2 ± 2,5 points respectively, surpassing the Minimally Clinically Important Difference after total shoulder arthroplasty. No revisions were necessary. CT scans identified 30% osteolysis in the posterior-medial calcar region, devoid of clinical repercussions. No risk factors were associated with bone osteolysis.

Conclusions

At an average follow-up of 31 months, intuitive shoulder arthroplasty Stemless implant provided favorable clinical results. CT analysis revealed osteolysis-like remodeling in the posterior-medial zone of the calcar (30%), without decline in clinical outcomes and revisions. Long-term follow-up studies are mandated to evaluate whether osteolysis is associated with negative consequences.
导言:无茎解剖型全肩关节成形术的使用率正在上升。骺固定会导致放射学上的骨重塑,据报道,在某些系列研究中,骨重塑超过了40%。本研究的目的是介绍平均随访31个月后,采用非对称中央骺固定的无柄植入物的临床和放射学结果:这项多中心回顾性研究审查了使用ISA无茎假体进行全解剖关节成形术并随访至少2年的患者的前瞻性数据。临床评估包括术前和最终随访测量的主动活动范围(ROM)、Constant评分和主观肩关节值(SSV)。通过标准化计算机断层扫描(CT 扫描)评估 2 年随访的骺端解剖重建和骨重塑情况。统计分析根据变量类型采用非配对学生t检验或卡方检验,使用EasyMedStat软件(3.22版;www.easymedstat.com)进行。结果:50 名患者(平均年龄 68 岁,62% 为女性)接受了随访,平均随访时间为 31 个月(24-44 个月)。主要适应症为原发性骨关节炎(68%)和A型盂关节炎(78%)。Constant评分和SSV平均值从38±11分显著提高到76±11分(P结论:在平均 31 个月的随访中,ISA 无茎假体取得了良好的临床效果。CT分析显示,小腿后内侧区域有类似溶骨的重塑(30%),但临床效果和翻修率并未下降。有必要进行长期随访研究,以评估骨溶解是否会带来不良后果。
{"title":"Clinical results and computed tomography analysis of intuitive shoulder arthroplasty (ISA) stemless at a minimum follow-up of 2 years","authors":"Cerise Gosselin MD ,&nbsp;Yves Lefebvre MD ,&nbsp;Thierry Joudet MD ,&nbsp;Arnaud Godeneche MD ,&nbsp;Johannes Barth MD ,&nbsp;Jérome Garret MD ,&nbsp;Stéphane Audebert MD ,&nbsp;Christophe Charousset MD ,&nbsp;Shoulder Friends Institute ,&nbsp;Nicolas Bonnevialle MD, PhD","doi":"10.1016/j.jse.2024.04.012","DOIUrl":"10.1016/j.jse.2024.04.012","url":null,"abstract":"<div><h3>Background</h3><div>The utilization of stemless anatomic total shoulder arthroplasty is on the rise. Epiphyseal fixation leads to radiological bone remodeling, which has been reported to exceed 40% in certain studies series. The aim of this study was to present the clinical and radiological outcomes of a stemless implant with asymmetric central epiphyseal fixation at an average follow-up of 31 months.</div></div><div><h3>Materials and methods</h3><div>This retrospective multicenter study examined prospective data of patients undergoing total anatomic arthroplasty with intuitive shoulder arthroplasty Stemless implant and followed up at least 2 years. Clinical assessment included preoperative and final follow-up measurements of active range of motion, Constant score, and Subjective Shoulder Value. Anatomical epiphyseal reconstruction and bone remodeling at the 2-year follow-up were assessed by standardized computed tomography scanner (CT scan). Statistical analysis employed unpaired Student's t-test or chi-squared test depending on the variable type, conducted using EasyMedStat software (version 3.22; <span><span>www.easymedstat.com</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>Fifty patients (mean age 68 years, 62% females) were enrolled, with an average follow-up of 31 months (24-44). Primary osteoarthritis (68%) with type A glenoid (78%) was the prevailing indication. The mean Constant score and Subjective Shoulder Value improved significantly from 38 ± 11 to 76 ± 11 (<em>P</em> &lt; .001) and from 31% ± 16 to 88% ± 15 (<em>P</em> &lt; .001) respectively at the last follow-up. Forward elevation, external rotation, and internal rotation range of motion increased by 39° ± 42, 28° ± 21 and 3,2 ± 2,5 points respectively, surpassing the Minimally Clinically Important Difference after total shoulder arthroplasty. No revisions were necessary. CT scans identified 30% osteolysis in the posterior-medial calcar region, devoid of clinical repercussions. No risk factors were associated with bone osteolysis.</div></div><div><h3>Conclusions</h3><div>At an average follow-up of 31 months, intuitive shoulder arthroplasty Stemless implant provided favorable clinical results. CT analysis revealed osteolysis-like remodeling in the posterior-medial zone of the calcar (30%), without decline in clinical outcomes and revisions. Long-term follow-up studies are mandated to evaluate whether osteolysis is associated with negative consequences.</div></div>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":"34 2","pages":"Pages e93-e102"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Downregulation of interleukin 11 regulates the transforming growth factor-β/ERK1/2 signaling pathway to inhibit articular capsule fibrosis and alleviate post-traumatic articular capsule contracture 下调 IL-11 可调节 TGFβ/ERK1/2 信号通路,从而抑制关节囊纤维化并缓解创伤后关节囊挛缩。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.057
Heng Zheng MD , Zhen-Jia Zhong MD , Yi-Chong Wang MD , Yang-Bai Sun PhD , Feng-Feng Li PhD

Background

Post-traumatic capsular contracture is a common complication of joint injury and surgery. Post-traumatic capsular contracture is associated with fibrosis characterized by excessive differentiation and proliferation of myofibroblasts and abnormal secretion and accumulation of extracellular matrix. Previous studies have suggested that interleukin 11 (IL11) plays a role in myocardial fibrosis. We thus hypothesized that IL11 may play a fibrotic role during capsular contracture, in order to discover new targets for preventing joint capsule contracture.

Methods

We constructed a post-traumatic contracture model by excessively extending the knee joint and fixing the joint in the flexion position, and a post-traumatic joint capsule contracture model was constructed in the wild-type, IL11−/−, IL11 R −/−, α-SMA-cre-IL11fl/fl, α-SMA-cre-IL11Rfl/fl mouse strain, with wild-type mice without any treatment of the knee joint as the control group. Fibrotic markers and the expression of IL11 and IL11 R in knee joint tissue were detected in each group of mice. The NIH3T3 cell line was used for in vitro analyses. The expression of fibrosis markers, IL11, transforming growth factor-β, and ERK1/2 were detected by western blot, enzyme-linked immunosorbent assay, and real time quantitative polymerase chain reaction.

Results

Inhibition of IL11 inhibited ERK1/2 phosphorylation, reduced the secretion of collagen in the joint capsule, and inhibited the excessive differentiation and proliferation of myofibroblasts in the post-traumatic joint capsule contracture, thus alleviating the joint capsule contracture and obtaining better joint mobility.

Conclusion

Downregulation of IL11 in traumatic joint capsule contracture inhibits ERK1/2 phosphorylation, thus significantly relieving joint capsule contracture. Our findings indicate the transforming growth factor-β/IL11/ERK1/2 axis is an important pathway for the differentiation of fibroblasts into myofibroblasts. Anti-IL11 treatment is an effective means to prevent traumatic joint capsule contracture.
背景:创伤后关节囊挛缩是关节损伤和手术的常见并发症。创伤后关节囊挛缩与纤维化有关,其特点是肌成纤维细胞过度分化和增殖,细胞外基质异常分泌和积聚。以前的研究表明,IL11 在心肌纤维化中发挥作用。因此,我们推测 IL11 可能在关节囊挛缩过程中起纤维化作用,从而发现预防关节囊挛缩的新靶点 方法:我们通过过度伸展膝关节并将其固定在屈曲位来构建创伤后关节挛缩模型,并在野生型、IL11-/-、IL11R -/-、α-SMA-cre-IL11fl/fl、α-SMA-cre-IL11Rfl/fl小鼠品系中构建创伤后关节囊挛缩模型,以未对膝关节进行任何处理的野生型小鼠为对照组。检测各组小鼠膝关节组织中的纤维化标志物以及 IL11 和 IL11R 的表达。体外分析使用的是 NIH3T3 细胞系。通过 Western 印迹、ELISA 和 RT-qPCR 检测纤维化标志物、IL11、TGFβ 和 ERK1/2 的表达:结果:抑制IL11可抑制ERK1/2磷酸化,减少关节囊胶原蛋白的分泌,抑制创伤后关节囊挛缩中肌成纤维细胞的过度分化和增殖,从而缓解关节囊挛缩,获得更好的关节活动度:结论:在创伤性关节囊挛缩中下调 IL11 可抑制 ERK1/2 磷酸化,从而显著缓解关节囊挛缩。我们的研究结果表明,TGFβ/IL11/ERK1/2 轴是成纤维细胞分化为肌成纤维细胞的重要途径。抗IL11治疗是预防创伤性关节囊挛缩的有效手段。
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引用次数: 0
Navigated augmented reality through a head-mounted display leads to low deviation between planned, intra- and postoperative parameters during glenoid component placement of reverse shoulder arthroplasty: a proof-of-concept case series 在反向肩关节置换术中,通过头戴式显示器导航的增强现实技术可使计划参数、术中参数和术后参数之间的偏差降低:概念验证案例系列。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.05.006
J. Tomás Rojas MD , Jennifer Menzemer MD , Mustafa S. Rashid MD, PhD , Annabel Hayoz MSc , Alexandre Lädermann MD , Matthias A. Zumstein MD

Background

Navigated augmented reality (AR) through a head-mounted display (HMD) has led to accurate glenoid component placement in reverse shoulder arthroplasty (RSA) in an in-vitro setting. The purpose of this study is to evaluate the deviation between planned, intraoperative, and postoperative inclination, retroversion, entry point, and depth of the glenoid component placement during RSA, assisted by navigated AR through an HMD, in a surgical setting.

Methods

A prospective, multicenter study was conducted. All consecutive patients undergoing RSA in 2 institutions, between August 2021 and January 2023, were considered potentially eligible for inclusion in the study. Inclusion criteria were as follows: age >18 years, surgery assisted by AR through an HMD, and postoperative computed tomography (CT) scans at 6 weeks. All participants agreed to participate in the study and informed consent was provided in all cases. Preoperative CT scans were undertaken for all cases and used for 3-dimensional (3D) planning. Intraoperatively, glenoid preparation and component placement were assisted by a navigated AR system through an HMD in all patients. Intraoperative parameters were recorded by the system. A postoperative CT scan was undertaken at 6 weeks, and 3D reconstruction was performed to obtain postoperative parameters. The deviation between planned, intraoperative, and postoperative inclination, retroversion, entry point, and depth of the glenoid component placement was calculated. Outliers were defined as >5° for inclination and retroversion and >5 mm for entry point.

Results

Seventeen patients (9 females, 12 right shoulders) with a mean age of 72.8 ± 9.1 years (range, 47.0-82.0) met inclusion criteria. The mean deviation between intra- and postoperative measurements was 1.5° ± 1.0° (range, 0.0°-3.0°) for inclination, 2.8° ± 1.5° (range, 1.0°-4.5°) for retroversion, 1.8 ± 1.0 mm (range, 0.7-3.0 mm) for entry point, and 1.9 ± 1.9 mm (range, 0.0-4.5 mm) for depth. The mean deviation between planned and postoperative values was 2.5° ± 3.2° (range, 0.0°-11.0°) for inclination, 3.4° ± 4.6° (range, 0.0°-18.0°) for retroversion, 2.0 ± 2.5 mm (range, 0.0°-9.7°) for entry point, and 1.3 ± 1.6 mm (range, 1.3-4.5 mm) for depth. There were no outliers between intra- and postoperative values and there were 3 outliers between planned and postoperative values. The mean time (minutes : seconds) for the tracker unit placement and the scapula registration was 03:02 (range, 01:48 to 04:26) and 08:16 (range, 02:09 to 17:58), respectively.

Conclusion

The use of a navigated AR system through an HMD in RSA led to low deviations between planned, intraoperative, and postoperative parameters for glenoid component placement.
背景:在体外环境下,通过头戴式显示器(HMD)导航的增强现实(AR)技术已在反向肩关节置换术(RSA)中实现了准确的盂成形组件置放。本研究的目的是评估在手术环境中,通过头戴式显示器的AR导航辅助下,RSA术中盂部件放置的计划、术中和术后倾斜度、后倾角、进入点和深度之间的偏差:进行了一项前瞻性多中心研究。在 2021 年 8 月至 2023 年 1 月期间,在两家医疗机构接受 RSA 手术的所有连续患者都被认为可能符合纳入研究的条件。纳入标准为:年龄大于 18 岁,通过 HMD 进行 AR 辅助手术,术后六周进行计算机断层扫描 (CT)。所有参与者均同意参与研究,并提供了知情同意书。所有病例都进行了术前 CT 扫描,并用于三维(3D)规划。术中,所有患者的盂成形准备和组件置入均由通过 HMD 导航的 AR 系统协助完成。术中参数由系统记录。术后 6 周进行 CT 扫描,并使用三维重建技术获取术后参数。计算了计划中、术中和术后髋臼组件放置的倾斜度、后倾度、进入点和深度之间的偏差。异常值的定义是:倾斜和后倾>5°,进入点>5 mm:17名患者(9名女性,12名右肩)符合纳入标准,平均年龄为(72.8±9.1)岁(范围为47.0至82.0)。术中和术后测量的平均偏差为:倾斜度为 1.5°±1.0°(范围为 0.0°至 3.0°),后倾角为 2.8°±1.5°(范围为 1.0°至 4.5°),切入点为 1.8±1.0mm(范围为 0.7mm 至 3.0mm),深度为 1.9±1.9mm(范围为 0.0mm 至 4.5mm)。计划值与术后值之间的平均偏差为:倾斜度为 2.5°±3.2°(范围为 0.0°至 11.0°),后倾角为 3.4°±4.6°(范围为 0.0°至 18.0°),切入点为 2.0±2.5mm(范围为 0.0°至 9.7°),深度为 1.3±1.6mm(范围为 1.3mm 至 4.5mm)。术中值和术后值之间没有异常值,计划值和术后值之间有三个异常值。追踪器放置和肩胛骨登记的平均时间(分:秒)分别为03:02(范围为01:48至04:26)和08:16(范围为02:09至17:58):通过 HMD 在 RSA 中使用 AR 导航系统,髋臼组件置放的计划参数、术中参数和术后参数之间的偏差较小。
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引用次数: 0
Does the addition of Patient-Reported Outcome Measure Information System (PROMIS) pain instruments improve the sensitivity of PROMIS upper extremity scores after arthroscopic rotator cuff repair? 关节镜下肩袖修复术后增加 PROMIS 疼痛工具是否能提高 PROMIS 上肢评分的灵敏度?
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2025-02-01 DOI: 10.1016/j.jse.2024.06.002
Matthew G. Alben DO , Paul V. Romeo MD , Aidan G. Papalia DO, MBA , Andrew J. Cecora BS , Young W. Kwon MD, PhD , Andrew S. Rokito MD , Joseph D. Zuckerman MD , Mandeep S. Virk MD

Background

Although Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (P-UE) has been validated in upper extremity orthopedics, its ability to capture a patient’s functional recovery after arthroscopic rotator cuff repair (aRCR), as measured by its responsiveness, is minimal in the early postoperative period. The primary purpose of this study is to determine if the addition of PROMIS Pain Intensity (P-Intensity) or Pain Interference (P-Interference) scores to PROMIS UE improves the responsiveness throughout the 1-year postoperative period after aRCR.

Methods

This prospective, longitudinal study included 100 patients who underwent aRCR. Patients completed P-UE, P-Interference, P-Intensity, American Shoulder and Elbow Surgeons, and Western Ontario Rotator Cuff Index scores preoperatively and at 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after surgery. Responsiveness at each time point relative to preoperative baseline and 1-way analysis of variance with post hoc analysis was conducted for each PROM. The responsiveness of the outcome score was determined using the effect size, graded as small (0.2), medium (0.5), or large (0.8). The Pearson correlation coefficient (r) was determined between these instruments at each time point.

Results

In isolation, P-UE, P-Interference, and P-Intensity showed a medium-large ability to detect change (positive and negative) throughout the 1-year postoperative period. The addition of PROMIS pain scores to P-UE improved the responsiveness of the instrument (from medium to a large effect size) starting at 3 months and continued throughout the 12-month follow-up period. Although the addition of pain scores increases the response burden for PROMIS, this was still lower than the response burden for the legacy outcome scores (P < .05).

Conclusion

The addition of PROMIS pain instruments improves the responsiveness of the P-UE function score in patients undergoing aRCR.
导言:虽然患者报告结果测量信息系统(PROMIS)上肢(P-UE)已在上肢矫形术中得到验证,但在术后早期,该系统捕捉患者在关节镜下肩袖修复术(aRCR)后功能恢复情况的能力(通过其反应性来衡量)却微乎其微。本研究的主要目的是确定在 PROMIS UE 中添加 PROMIS 疼痛强度(P-Intensity)或疼痛干扰(P-Interference)评分是否能改善肩袖修复术后一年内的反应性:这项前瞻性纵向研究包括 100 名接受 aRCR 的患者。患者在术前和术后 2 周、6 周、3 个月、6 个月和 12 个月分别完成了 P-UE、P-Interference、P-Intensity、美国肩肘外科医生(ASES)和西安大略肩袖指数(WORC)评分。每个时间点相对于术前基线的反应性,对每个 PROM 进行单因素方差分析和事后分析。结果评分的反应性采用效应大小(ES)来确定,效应大小分为小(0.2)、中(0.5)或大(0.8)。在每个时间点确定这些工具之间的皮尔逊相关系数(r):结果:单独使用 P-UE、P-Interference 和 P-Intensity,在术后一年内检测变化(阳性和阴性)的能力为中-大。在 P-UE 中加入 PROMIS 疼痛评分后,从 3 个月开始并在 12 个月的随访期间,该工具的反应性得到了提高(从中等效应大小提高到较大效应大小)。虽然增加疼痛评分会增加 PROMIS 的响应负担,但与传统结果评分的响应负担相比,响应负担仍然较低(p 结论:在接受 aRCR 的患者中增加 PROMIS 疼痛工具可提高 P-UE 功能评分的响应能力。
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引用次数: 0
期刊
Journal of Shoulder and Elbow Surgery
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