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The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator? AMP激活的蛋白激酶在氧化/费罗普托过程中的作用：保护剂还是增效剂？
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2024-12-01 Epub Date: 2022-04-08 DOI: 10.1089/ars.2022.0013
Antonio Currais, Devin Kepchia, Zhibin Liang, Pamela Maher

Significance: Evidence for a role for the oxytosis/ferroptosis regulated cell death pathway in aging and neurodegenerative diseases has been growing over the past few years. Because of this, there is an increasing necessity to identify endogenous signaling pathways that can be modulated to protect cells from this form of cell death. Recent Advances: Recently, several studies have identified a protective role for the AMP-activated protein kinase (AMPK)/acetyl CoA carboxylase 1 (ACC1) pathway in oxytosis/ferroptosis. However, there are also a number of studies suggesting that this pathway contributes to cell death initiated by various inducers of oxytosis/ferroptosis. Critical Issues: The goals of this review are to provide an overview and analysis of the published studies and highlight specific areas where more research is needed. Future Directions: Much remains to be learned about AMPK signaling in oxytosis/ferroptosis, especially the conditions where it is protective. Furthermore, the role of AMPK signaling in the brain and especially the aging brain needs further investigation.

意义重大：在过去几年中，有越来越多的证据表明，氧合/铁变态调节细胞死亡途径在衰老和神经退行性疾病中发挥作用。因此，越来越有必要确定可调节的内源性信号通路，以保护细胞免受这种形式的细胞死亡。最新进展最近，有几项研究确定了 AMP 激活蛋白激酶（AMPK）/乙酰辅酶羧化酶 1（ACC1）通路在氧中毒/铁中毒中的保护作用。然而，也有一些研究表明，该途径会导致细胞在各种氧合/铁变态诱导剂的作用下死亡。关键问题：本综述旨在概述和分析已发表的研究，并强调需要开展更多研究的具体领域。未来方向：关于 AMPK 信号在氧合/铁变态反应中的作用，尤其是在哪些情况下具有保护作用，还有许多问题有待了解。此外，AMPK 信号在大脑中的作用，尤其是在老化大脑中的作用还需要进一步研究。
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引用次数: 0
An Engineering Learning Community to Promote Retention and Graduation for Community College Students 一个促进社区大学学生留校和毕业的工程学习社区
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000424
James Maccariella, Shana L. Pribesh, Mitchell R. Williams
AbstractThis study explores an intervention for community college engineering students that holds promise for strengthening the production of engineers. While learning communities at four-year univ...
摘要本研究探讨社区大学工程专业学生的干预措施，以期加强工程师的培养。在四年制大学学习社区时……
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引用次数: 2
Mastery-Level Achievement Method for Assessing Module-Based Educational Tools 基于模块的教育工具评估的掌握级成就法
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000417
Ziaur Rahman, S. Mattingly, Colleen Casey, Sunil K. Madanu
AbstractActive-based learning techniques provide an effective pedagogical strategy to support student learning. This paper describes the development of new assessment techniques to evaluate an acti...
摘要主动学习技术为支持学生学习提供了一种有效的教学策略。本文描述了新的评估技术的发展，以评估一个活动。
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引用次数: 0
Exploring Engineering Undergraduate Students’ Attitudes toward Mathematical Problem Posing 工科大学生数学命题态度探究
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000418
Mahboubeh Nedaei, Farzad Radmehr, Michael Drake
AbstractMathematics has a key role to play in engineering education. Without strong mathematical knowledge, engineering students often face difficulties in engineering courses. Previous studies hav...
数学在工程教育中发挥着重要作用。如果没有很强的数学知识，工科学生在工程课程中经常会遇到困难。以前的研究已经。。。
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引用次数: 13
Differences in Stakeholder Ability in Addressing Unethical Practices: Insights from the Surveying Profession 利益相关者处理不道德行为能力的差异:来自测量专业的见解
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000426
P. Manu, K. Agyekum, Abdul–Majeed Mahamadu, P. Olomolaiye, E. Adinyira
AbstractWhile several measures have been suggested to address unethical practices within the built environment, it remains unclear whether some stakeholders are more able to influence improvement i...
摘要虽然已经提出了一些措施来解决建筑环境中的不道德行为，但尚不清楚一些利益相关者是否更有能力影响改善。。。
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引用次数: 7
Disciplinary Variations in Ethics and Societal Impact Topics Taught in Courses for Engineering Students 工科学生课程中伦理学和社会影响主题的学科差异
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000415
A. Bielefeldt, M. Polmear, D. Knight, N. Canney, Chris Swan
AbstractThis research explored disciplinary differences in the ethics and societal impact (ESI) topics taught to engineering and computing students. Differences were predicted based on the codes of...
摘要本研究探讨工程与计算机专业学生在伦理与社会影响(ESI)主题教学中的学科差异。根据……的代码预测了差异。
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引用次数: 17
Problem-Based Learning for Adaptability and Management Skills 基于问题的适应性和管理技能学习
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000420
Todd L. Sirotiak, Achintyamugdha Sharma
AbstractThis work discusses how problem-based learning (PBL) was used in a senior capstone class for two semesters. The effects of PBL were investigated by conducting preassessment and postassessme...
摘要这项工作讨论了基于问题的学习（PBL）是如何在两个学期的高年级压轴课程中使用的。通过对PBL的预评价和后评价，探讨了PBL的作用。。。
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引用次数: 6
Text Mining–Based Review of Articles Published in the Journal of Professional Issues in Engineering Education and Practice 基于文本挖掘的《工程教育与实践专业期刊》文章综述
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000425
Wei Chen, Yidong Xu, R. Jin, D. Wanatowski
AbstractThis study extends the existing reviews targeting the Journal of Professional Issues in Engineering Education and Practice (JPIEEP) by incorporating the text-mining review methodology. A to...
摘要本研究扩展了现有的针对工程教育与实践专业问题期刊(jjpieep)的评论，并结合了文本挖掘的评论方法。一个……
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引用次数: 9
Relationship between Gender Segregation and Students’ Occupational Preferences in Building Engineering 建筑工程专业性别隔离与学生职业偏好的关系
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000422
Margarita Infante-Perea, Marisa Román-Onsalo, E. Navarro-Astor
AbstractHorizontal and vertical gender segregation is self-evident within the construction sector. In Spain, as in other countries, women have obtained qualified technical work thanks to their educ...
摘要:在建筑行业，横向和纵向的性别隔离是不言而喻的。在西班牙，和其他国家一样，妇女由于受过教育而获得了合格的技术工作。
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引用次数: 4
Teaching Community Engagement to Engineers via a Workshop Approach 通过工作坊的方式向工程师教授社区参与
Q1 Business, Management and Accounting
Journal of Professional Issues in Engineering Education and Practice
Pub Date : 2019-10-01 DOI: 10.1061/(ASCE)EI.1943-5541.0000416
Thomas S. Woodson, Matthew Harsh, M. Bernstein, S. Cozzens, Jameson M. Wetmore, R. Castillo
AbstractEngineers design and create solutions to solve problems and positively impact people’s lives. Unfortunately, traditional engineering training does not prepare students to engage with the pe...
工程师设计和创造解决方案来解决问题，并对人们的生活产生积极影响。不幸的是，传统的工程培训并没有让学生做好参与体育运动的准备。。。
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引用次数: 3
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