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Monitoring the operating state of crystal growth process based on digital twin model 基于数字孪生模型监控晶体生长过程的运行状态
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-19 DOI: 10.1016/j.jprocont.2024.103261
Yu-Yu Liu , Ling-Xia Mu , Ding Liu

The reliable assessment of the operational status during the silicon single crystal growth process is a prerequisite for ensuring system safety and improving crystal quality. However, in the actual silicon single crystal growth process, due to limitations in manpower, material resources, financial resources, and current technical methods, the establishment of monitoring models is still in its infancy. To address this issue, this paper proposes a hybrid deep belief network (HDBN) algorithm aided by the digital twin (DT) model to achieve real-time monitoring of equipment operational status. Firstly, this study constructs the DT model based on the basic principles of crystal growth, mainly to achieve high-precision simulation of the actual silicon single crystal growth process and generate abnormal data for the equipment. This operation can expand the sample set, enhance the diversity and coverage of data, and effectively solve the problem of insufficient sample size. Secondly, this study uses the variational mode decomposition (VMD) algorithm to decompose the dataset composed of obtained abnormal and normal data, and constructs sub-deep belief network (DBN) for the decomposed subsequences to capture deep feature information at different frequencies of the data. Subsequently, based on the concept of ensemble learning, the outputs of each sub-DBN network are used as inputs to construct the overall DBN network, achieving monitoring of the equipment operational status. Through the combination of VMD decomposition and DBN networks, this algorithm can better capture the frequency characteristics and time-domain features of the signal, enhancing monitoring accuracy. Experimental results show that this algorithm can accurately identify abnormal equipment states, effectively improve monitoring performance, and is of significant importance for the optimization and control of the semiconductor-grade silicon single crystal growth process, contributing to increased production efficiency and product quality.

对硅单晶生长过程中的运行状态进行可靠评估,是确保系统安全和提高晶体质量的前提。然而,在实际的硅单晶生长过程中,由于人力、物力、财力以及现有技术手段的限制,监测模型的建立仍处于起步阶段。针对这一问题,本文提出了一种以数字孪生(DT)模型为辅助的混合深度信念网络(HDBN)算法,以实现对设备运行状态的实时监控。首先,本研究基于晶体生长的基本原理构建了 DT 模型,主要实现对实际硅单晶生长过程的高精度模拟,并生成设备的异常数据。这一操作可以扩大样本集,增强数据的多样性和覆盖面,有效解决样本量不足的问题。其次,本研究利用变异模态分解(VMD)算法对获取的异常数据和正常数据组成的数据集进行分解,并对分解后的子序列构建子深度信念网络(DBN),以捕捉数据不同频率的深度特征信息。随后,基于集合学习的概念,将各子 DBN 网络的输出作为输入,构建整体 DBN 网络,实现对设备运行状态的监测。通过 VMD 分解与 DBN 网络的结合,该算法能更好地捕捉信号的频率特性和时域特征,提高监测精度。实验结果表明,该算法能准确识别设备异常状态,有效提高监测性能,对半导体级硅单晶生长过程的优化和控制具有重要意义,有助于提高生产效率和产品质量。
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引用次数: 0
An adaptive control system based on spatial–temporal graph convolutional and disentangled baseline-volatility prediction of bellows temperature for iron ore sintering process 基于时空图卷积和分解基线-波动预测的铁矿石烧结过程风箱温度自适应控制系统
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-18 DOI: 10.1016/j.jprocont.2024.103254
Zhengwei Chi, Xiaoxia Chen, Hanzhong Xia, Chengshuo Liu, Zhen Wang

The temperature within the sintering furnace is a decisive factor influencing the quality of the sintered ore in the iron ore sintering process. In practical operations, the temperature at the bellows directly linked to the bed layer indirectly signifies the internal furnace temperature. Maintaining a stable temperature at the bellows, particularly at the burn-through point, is vital for minimizing gas emissions, improving carbon efficiency, and enhancing the quality of the sintered ore. This paper proposes an intelligent temperature control system based on Spatial–Temporal Graph Convolutional and Disentangled Baseline-Volatility (STGCDBV) prediction. The STGCDBV network comprises three parallel modules: Adaptive Graph Convolution Network (AGCN), Baseline and Volatility Disentangler (BVD), and a residual link, along with a Temporal–Nodal Encoder–Decoder (TNED) module. The AGCN constructs a graph reflecting the characteristics of bellows temperature, effectively merging static spatial data with dynamic thermal information. The BVD module captures the nonlinear trend data inherent in the sintering process. In contrast, the TNED synergizes the insights from the parallel modules using cross encoding and decoding functionalities. For controlling the sintering gas flow rate, a Model Reference Adaptive Control (MRAC) system is implemented, which utilizes a control scheme founded on a temperature reference model and iterative parameter adjustments. Extensive experiments using actual time-series data from a steel plant have been conducted. Moreover, comparisons between the performance of pre- and post-control interventions demonstrate that the STGCDBV-MRAC system can stabilize temperature fluctuations and exhibit exemplary control proficiency.

在铁矿石烧结工艺中,烧结炉内的温度是影响烧结矿质量的决定性因素。在实际操作中,与床层直接相连的风箱温度间接反映了炉内温度。保持波纹管温度稳定,尤其是烧穿点温度稳定,对于减少气体排放、提高碳效率和提高烧结矿质量至关重要。本文提出了一种基于空间-时间图卷积和分离基线-波动率(STGCDBV)预测的智能温度控制系统。STGCDBV 网络由三个并行模块组成:自适应图卷积网络(AGCN)、基线与波动解缠器(BVD)、残差链路以及时序节点编码器-解码器(TNED)模块。AGCN 构建了一个反映波纹管温度特征的图形,有效地将静态空间数据与动态热信息融合在一起。BVD 模块捕捉烧结过程中固有的非线性趋势数据。相比之下,TNED 利用交叉编码和解码功能将并行模块的洞察力协同起来。为控制烧结气体流量,采用了模型参考自适应控制(MRAC)系统,该系统利用基于温度参考模型和迭代参数调整的控制方案。利用一家钢铁厂的实际时间序列数据进行了大量实验。此外,控制前和控制后干预的性能比较表明,STGCDBV-MRAC 系统可以稳定温度波动,并表现出出色的控制能力。
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引用次数: 0
Manifold embedding stationary subspace analysis for nonstationary process monitoring with industrial applications 面向工业应用的非稳态过程监控的流形嵌入静态子空间分析
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-18 DOI: 10.1016/j.jprocont.2024.103262
Chunhua Yang , Zhihong Lin , Keke Huang , Dehao Wu , Weihua Gui

Industrial processes frequently exhibit nonstationary characteristics due to factors like load fluctuations and external interference. Accurate monitoring of nonstationary industrial processes is of vital importance in ensuring production stability and safety. Unfortunately, most existing monitoring methods overlook the manifold structure presented in nonstationary data due to nonstationary features, causing the loss of critical information and poor interpretability. As a consequence, monitoring performance is compromised. To address this issue, this paper proposes a manifold embedding stationary subspace analysis (MESSA) algorithm. By embedding a neighborhood preservation term into the objective function of SSA, MESSA effectively mitigates the impact of nonstationarity on manifold structure. The extracted features incorporate both global stationarity and local manifold characteristics, facilitating a more comprehensive reconstruction of the intricate underlying mechanisms in industrial processes. This contributes to a substantial enhancement in the accuracy and reliability of process monitoring. A set of nonstationary swiss-roll dataset is designed to visually demonstrate the capability of MESSA in extracting manifold structure. Case studies including a numerical case, a continuous stirred tank reactor system and a real industrial roasting process validate the superior monitoring performance of the proposed method.

由于负载波动和外部干扰等因素,工业流程经常表现出非稳态特性。准确监控非稳态工业过程对于确保生产稳定性和安全性至关重要。遗憾的是,现有的大多数监测方法都忽略了非稳态数据中由于非稳态特征而呈现的多方面结构,导致关键信息丢失,可解释性差。因此,监测性能大打折扣。针对这一问题,本文提出了一种流形嵌入静态子空间分析(MESSA)算法。通过在 SSA 的目标函数中嵌入邻域保护项,MESSA 有效地减轻了非静止性对流形结构的影响。提取的特征既包括全局静止性,也包括局部流形特征,有助于更全面地重建工业流程中错综复杂的内在机制。这有助于大大提高过程监控的准确性和可靠性。为了直观地展示 MESSA 在提取流形结构方面的能力,我们设计了一组非稳态swiss-roll 数据集。包括一个数值案例、一个连续搅拌罐反应器系统和一个实际工业焙烧过程在内的案例研究验证了所提方法的卓越监测性能。
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引用次数: 0
Modified active disturbance rejection control based on gain scheduling for circulating fluidized bed units 基于增益调度的循环流化床装置改进型主动干扰抑制控制
IF 3.3 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-14 DOI: 10.1016/j.jprocont.2024.103253
Zhenlong Wu , Donghai Li , Yanhong Liu , YangQuan Chen

Circulating fluidized bed (CFB) units are extensively operated in China due to their wide fuel adaptability, low emissions and high combustion efficiency. Nevertheless, CFB units are facing many control challenges due to their strong nonlinearity and large lag characteristics. To handle these control challenges, a modified active disturbance rejection control based on gain scheduling is structured in this paper. Firstly, a decentralized active disturbance rejection control strategy based on gain scheduling is designed by analyzing control difficulties of CFB units. Then, the parameter tuning and scheduling methods are provided, and the convergence of the extended state observer during the scheduling process is derived theoretically. The advantages of the proposed method in tracking performance, disturbance rejection performance, and ability to reject fuel quality fluctuation and uncertain heat transfer coefficients are illustrated by comparative simulations. Finally, the proposed control strategy is practically applied to the main steam pressure system of a 300 MW CFB unit. Running data demonstrate that it has a faster tracking performance and better disturbance rejection ability in [50100]% of the rated load, where the hourly average integral absolute error index has decreased obviously, and it shows a good field application prospect.

循环流化床(CFB)机组具有燃料适应性广、排放低、燃烧效率高等特点,在中国得到广泛应用。然而,由于其较强的非线性和较大的滞后特性,CFB 机组面临着许多控制挑战。为了应对这些控制挑战,本文构建了一种基于增益调度的改进型主动扰动抑制控制。首先,通过分析 CFB 机组的控制难点,设计了基于增益调度的分散式主动干扰抑制控制策略。然后,提供了参数调整和调度方法,并从理论上推导了扩展状态观测器在调度过程中的收敛性。通过对比仿真,说明了所提方法在跟踪性能、干扰抑制性能以及抑制燃料质量波动和不确定传热系数能力方面的优势。最后,将提出的控制策略实际应用于 300 MW CFB 机组的主蒸汽压力系统。运行数据表明,在额定负荷的[50∼100]%范围内,该控制策略具有更快的跟踪性能和更好的扰动抑制能力,小时平均积分绝对误差指数明显下降,具有良好的现场应用前景。
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引用次数: 0
Semi-decentralized temperature control in district heating systems 区域供热系统中的半集中式温度控制
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-14 DOI: 10.1016/j.jprocont.2024.103251
Johan Simonsson , Khalid Tourkey Atta , Wolfgang Birk

The supply temperature in district heating systems has traditionally been controlled using feedforward – a robust and well-validated approach for district heating networks with few producers and relatively high supply temperatures. The transition towards lower temperature district heating networks allows for efficient reuse of excess heat from, e.g., industrial processes and data centers. Excess heat is often intermittent, cannot always be assumed to be possible to control with a centralized controller, and can cause temperature disturbances in the grid. Closing the loop using PID control is challenging due to the process’s time-varying nature and long time delays. Model Predictive Control (MPC) suffers from a higher complexity, long computational times, and the need for a well-validated and maintained centralized model. The paper suggests a semi-decentralized approach using the Smith predictor with an event-driven assignment of active controllers and sensors. A reduced order model based on a more comprehensive state space model is derived and used for gain scheduling and input–output pairing using the normalized relative gain array. The focus is on temperature disturbance rejection, and appropriate tuning rules and controller structures are suggested. Simulation results show that the proposed control structure can handle various types of temperature disturbances, even in the presence of model estimation errors.

传统上,区域供热系统的供热温度是通过前馈控制的,对于生产商较少、供热温度相对较高的区域供热网络来说,这是一种稳健且经过验证的方法。向温度较低的区域供热网络过渡,可有效再利用工业流程和数据中心等产生的多余热量。过剩热量通常是间歇性的,不能总是认为可以通过集中控制器进行控制,而且可能会对电网造成温度干扰。由于过程的时变性和较长的时间延迟,使用 PID 控制来闭环具有挑战性。模型预测控制 (MPC) 的缺点是复杂性较高、计算时间较长,而且需要一个经过充分验证和维护的集中模型。本文提出了一种半分散的方法,即使用史密斯预测器,以事件驱动的方式分配主动控制器和传感器。在一个更全面的状态空间模型的基础上,推导出一个减阶模型,并使用归一化相对增益阵列进行增益调度和输入输出配对。重点是温度干扰抑制,并提出了适当的调整规则和控制器结构。仿真结果表明,即使存在模型估计误差,所提出的控制结构也能处理各种类型的温度干扰。
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引用次数: 0
Spatiotemporal-response-correlation-based model predictive control of heat conduction temperature field 基于时空响应相关性的热传导温度场模型预测控制
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-13 DOI: 10.1016/j.jprocont.2024.103257
Guangjun Wang , Zehong Chen , Hong Chen , Zhaohui Mao

In many engineering fields, controlling the transient temperature field of the heat conduction process is significant practically. For the temperature field control problem, a spatiotemporal-response-correlation-based model predictive control (STRC-MPC) method is developed. In this method, a spatiotemporal mapping eigenvector of control inputs to temperature field is determined by transient heat conduction equations. According to the correlation degree between the temporal mapping eigenvectors of different spatial points, a finite number of representative spatial points (RPs) are extracted, of which can cover the full mapping characteristic of the temperature field. Meanwhile, the predictive model of the temperature field is reduced offline to temperature predictive models of the RPs. Then, the predictive models of the RPs are applied to design a model predictive controller of the temperature field. In addition, a correlation formulation between the temperature responses of the RPs and that of the measurement points (MPs) is derived by making the control inputs as intermediate variable, and a correlation model between the predictive errors of the two kinds of points is established. Combining the correlation model and the predictive errors of the MPs, the predictive errors at the RPs are estimated and the feedback correction of the predictive model of the RPs is achieved. The STRC-MPC method is employed to control the preheating temperature field of a die casting mold by numerical simulations. The model predictive controller and the feedback correction scheme involved in the proposed control method are verified respectively.

在许多工程领域,控制热传导过程的瞬态温度场具有重要的实际意义。针对温度场控制问题,开发了一种基于时空响应相关性的模型预测控制(STRC-MPC)方法。该方法通过瞬态热传导方程确定控制输入到温度场的时空映射特征向量。根据不同空间点的时空映射特征向量之间的相关程度,提取出一定数量的代表性空间点(RPs),这些空间点能够覆盖温度场的全部映射特征。同时,将温度场的预测模型离线还原为 RP 的温度预测模型。然后,应用 RP 的预测模型设计温度场的模型预测控制器。此外,通过将控制输入作为中间变量,得出 RP 的温度响应与测量点(MP)的温度响应之间的相关公式,并建立两种点的预测误差之间的相关模型。结合相关模型和 MP 点的预测误差,估算出 RP 点的预测误差,实现对 RP 点预测模型的反馈修正。通过数值模拟,采用 STRC-MPC 方法控制压铸模具的预热温度场。分别验证了所提控制方法中涉及的模型预测控制器和反馈修正方案。
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引用次数: 0
Iterative learning robust MPC hybrid fault-tolerant control for multi-phase batch processes with asynchronous switching 针对异步切换的多阶段批处理过程的迭代学习鲁棒 MPC 混合容错控制
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-11 DOI: 10.1016/j.jprocont.2024.103250
Huiyuan Shi , Qianlin Yan , Hui Li , Jia Wu , Chengli Su , Ping Li

It is widely known that uncertainties, unknown disturbances, asynchronous switching, and partial actuator faults are the major factors that affect system stability during actual industrial production. For the above problems, a method of iterative learning robust MPC hybrid fault-tolerant control for multi-phase batch processes with asynchronous switching in two-dimensional systems is proposed. Exceptionally, an equivalent extended asynchronous switching fault-tolerant control model, including a synchronous sub-model and an asynchronous sub-model, is built. Then, Lyapunov theory, switching system theory, and so on are used as the theoretical basis, and the sufficient conditions to guarantee the stable operation of the system are given. Combined with the given conditions, the control law gain, the shortest running time, and the longest running time are solved in real time to eliminate the asynchronous switching situation problem. The state deviations of the system are corrected in time by avoiding the accumulation of the system state deviations over time, thus improving the control performance of the system. Meanwhile, by combining real-time control law gains with information about the batch direction, the method can significantly reduce the learning period of the controller and provide better control performance along the batch direction. Finally, the feasibility of the proposed method is verified with simulation experiments of the injection molding process.

众所周知,在实际工业生产过程中,不确定性、未知干扰、异步切换和部分执行器故障是影响系统稳定性的主要因素。针对上述问题,本文提出了一种针对二维系统中具有异步切换的多阶段批处理过程的迭代学习鲁棒 MPC 混合容错控制方法。特别地,建立了一个等效的扩展异步切换容错控制模型,包括同步子模型和异步子模型。然后,以李亚普诺夫理论、开关系统理论等为理论基础,给出了保证系统稳定运行的充分条件。结合给定条件,实时求解控制律增益、最短运行时间和最长运行时间,消除异步切换情况问题。通过避免系统状态偏差的长期累积,及时修正系统的状态偏差,从而提高系统的控制性能。同时,通过将实时控制法则增益与批量方向信息相结合,该方法可以大大缩短控制器的学习周期,并沿批量方向提供更好的控制性能。最后,通过注塑成型过程的模拟实验验证了所提方法的可行性。
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引用次数: 0
A big data-driven predictive control approach for nonlinear processes using behaviour clusters 使用行为集群的非线性过程大数据驱动预测控制方法
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-07 DOI: 10.1016/j.jprocont.2024.103252
Shuangyu Han , Yitao Yan , Jie Bao , Biao Huang

A novel big data-driven predictive control (BDPC) approach for nonlinear processes is proposed. To deal with nonlinear process behaviours, the process behaviour space, represented by a set of input–output variable trajectories, is partitioned into linear sub-behaviour spaces (clusters), based on linear inclusion of nonlinear behaviours. A behaviour space (represented using Hankel matrices) partitioning approach is developed based on subspace angles. During online control, the BDPC controller locates the most relevant linear sub-behaviour based on the current online trajectory, which is then used to determine predictive control actions using receding horizon optimisation. The incremental stability and dissipativity conditions are developed to attenuate the effect of the error of approximating linear sub-behaviours on the output and guarantee closed-loop stability. These conditions are implemented as additional constraints during online data-driven predictive control. An example of controlling the Hall–Héroult process is used to illustrate the proposed approach.

针对非线性过程提出了一种新颖的大数据驱动预测控制(BDPC)方法。为了处理非线性过程行为,根据非线性行为的线性包含关系,将输入输出变量轨迹集所代表的过程行为空间划分为线性子行为空间(群组)。基于子空间角度,开发了一种行为空间(使用汉克尔矩阵表示)划分方法。在在线控制过程中,BDPC 控制器会根据当前的在线轨迹找到最相关的线性子行为,然后利用后退视界优化来确定预测控制行动。开发增量稳定性和耗散性条件是为了减弱近似线性子行为的误差对输出的影响,并保证闭环稳定性。这些条件在在线数据驱动预测控制中作为附加约束条件实施。以控制霍尔-赫鲁特过程为例,说明了所提出的方法。
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引用次数: 0
Predicting goal attainment in process-oriented behavioral interventions using a data-driven system identification approach 使用数据驱动的系统识别方法预测过程导向行为干预的目标实现情况
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-05-27 DOI: 10.1016/j.jprocont.2024.103242
Sarasij Banerjee , Rachael T. Kha , Daniel E. Rivera , Eric Hekler

Behavioral interventions (such as those developed to increase physical activity, achieve smoking cessation, or weight loss) can be represented as dynamic process systems incorporating a multitude of factors, ranging from cognitive (internal) to environmental (external) influences. This facilitates the application of system identification and control engineering methods to address questions such as: what drives individuals to improve health behaviors (such as engaging in physical activity)? In this paper, the goal is to efficiently estimate personalized, dynamic models which in turn will lead to control systems that can optimize this behavior. This problem is examined in system identification applied to the Just Walk study that aimed to increase walking behavior in sedentary adults. The paper presents a Discrete Simultaneous Perturbation Stochastic Approximation (DSPSA)-based modeling of the Goal Attainment construct estimated using AutoRegressive with eXogenous inputs (ARX) models. Feature selection of participants and ARX order selection is achieved through the DSPSA algorithm, which efficiently handles computationally expensive calculations. DSPSA can search over large sets of features as well as regressor structures in an informed, principled manner to model behavioral data within reasonable computational time. DSPSA estimation highlights the large individual variability in motivating factors among participants in Just Walk, thus emphasizing the importance of a personalized approach for optimized behavioral interventions.

行为干预措施(如为增加体育锻炼、戒烟或减肥而开发的干预措施)可以表示为包含多种因素的动态过程系统,这些因素包括认知(内部)影响因素和环境(外部)影响因素。这有助于应用系统识别和控制工程方法来解决以下问题:是什么促使个人改善健康行为(如参加体育锻炼)?本文的目标是有效估算个性化动态模型,进而建立能够优化这种行为的控制系统。本文通过系统识别对这一问题进行了研究,并将其应用于旨在增加久坐不动的成年人步行行为的研究中。本文介绍了一种基于离散同步扰动随机逼近(DSPSA)的建模方法,该方法使用具有外生输入的自回归(ARX)模型对结构进行估计。参与者的特征选择和 ARX 序列选择是通过 DSPSA 算法实现的,该算法可有效处理计算成本高昂的计算。DSPSA 可以在合理的计算时间内,以知情、有原则的方式搜索大量特征集和回归器结构,从而为行为数据建模。DSPSA 估算突出了《侏罗纪世界》中参与者在动机因素方面的巨大个体差异,从而强调了个性化方法对于优化行为干预的重要性。
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引用次数: 0
Data-driven identification and comparison of full multivariable models for propofol–remifentanil induced general anesthesia 数据驱动的异丙酚-瑞芬太尼诱导全身麻醉全多变量模型的识别与比较
IF 4.2 2区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-05-27 DOI: 10.1016/j.jprocont.2024.103243
Erhan Yumuk , Dana Copot , Clara M. Ionescu , Martine Neckebroek

In this paper, we present results with clinical data to enable a 2x2 input–output multivariable patient model for hypnosis and analgesia. Nonlinear multi-drug interaction models are identified from data recorded from 70 patients undergoing surgery during total intravenous anesthesia (TIVA) with several medical monitors for variables such as Bispectral Index, Nociception level (Medasense), skin conductance (Medstorm) and advanced spectral analysis conductance (AnspecPro). Bispectral index measures the depth of hypnosis (lack of consciousness), while nociception related indices from Medasense, Medstorm, and AnspecPro devices measure levels related to analgesia (lack of reaction to noxious stimuli). A comparison is given among three response surface model (RSM) structures – Minto, Greco, and Reduced Greco – for hypnotic and analgesic states during Propofol–Remifentanil interaction. The identified models capture the pharmacodynamic properties of dose–effect concentrations of Propofol/Remifentanil while the pharmacokinetic part of the patient model is calculated from patient’s biometric values using Schnider/Minto (SM), and Eleveld/Eleveld (EE) models. In presence of strict clinical protocols delivering data under poor identifiability conditions, we propose two methods of identification: (i) based on steady-state gains, and (ii) using all available data which includes part of the dynamic transient. The model parameters are optimized with Genetic Algorithm based on a goodness of fit performance measure complemented with root mean square error. The results suggest that the EE model combination is advantageous for Bispectral index pharmacokinetic modeling at the cost of numerical complexity, therefore reducing the uncertainty left to be identified in the pharmacodynamic part of the patient model. By contrast, the SM model combination is less computationally demanding and provides some improvement in the RSM accuracy for nociception level indicators. The comparison of three devices for nociception levels evaluation suggests that clinical data captured with the Medasense monitor provides best fitted RSMs with the Reduced Greco RSM structure, despite having fewer parameters.

在本文中,我们介绍了利用临床数据建立 2x2 输入输出多变量患者催眠和镇痛模型的结果。非线性多药相互作用模型是从 70 名接受全静脉麻醉(TIVA)手术的患者记录的数据中确定的,这些数据包括双光谱指数、痛觉水平(Medasense)、皮肤电导率(Medstorm)和高级频谱分析电导率(AnspecPro)等变量的多个医疗监控器。双谱指数测量的是催眠深度(缺乏意识),而 Medasense、Medstorm 和 AnspecPro 设备中与痛觉相关的指数测量的是与镇痛相关的水平(对有害刺激缺乏反应)。针对丙泊酚-瑞芬太尼相互作用过程中的催眠和镇痛状态,比较了三种反应曲面模型(RSM)结构--明托、格雷科和还原格雷科。已确定的模型捕捉到了丙泊酚/瑞芬太尼剂量效应浓度的药效学特性,而患者模型的药代动力学部分则是通过施奈德/明托(SM)和埃勒维尔德/埃勒维尔德(EE)模型,根据患者的生物特征值计算得出的。在严格的临床协议下,数据的可识别性较差,因此我们提出了两种识别方法:(i) 基于稳态增益;(ii) 使用所有可用数据,包括部分动态瞬态数据。模型参数采用遗传算法进行优化,该算法基于拟合优度和均方根误差。结果表明,EE 模型组合在双谱指数药代动力学建模方面具有优势,但代价是数值复杂性,因此减少了患者模型药效学部分有待确定的不确定性。相比之下,SM 模型组合对计算的要求较低,并在一定程度上提高了痛觉水平指标的 RSM 精确度。对用于评估痛觉水平的三种设备进行的比较表明,尽管参数较少,但通过 Medasense 监护仪采集的临床数据提供了与 Reduced Greco RSM 结构最匹配的 RSM。
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引用次数: 0
期刊
Journal of Process Control
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