Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0762
Sharon Wilks, Benedito Carneiro, Gregory Cote, Jason Henry, Shiraj Sen, Alexander I Spira, Frank Yung-Chin Tsai, Judy S Wang, Marsha Crochiere, Shui He, Sondra Smyrnios, Dipali Unadkat, Bin Zhang, Anthony W Tolcher
{"title":"762 A first-in-human phase 1 clinical study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the EDB+FN targeting ADC PYX-201 in participants with advanced solid tumors","authors":"Sharon Wilks, Benedito Carneiro, Gregory Cote, Jason Henry, Shiraj Sen, Alexander I Spira, Frank Yung-Chin Tsai, Judy S Wang, Marsha Crochiere, Shui He, Sondra Smyrnios, Dipali Unadkat, Bin Zhang, Anthony W Tolcher","doi":"10.1136/jitc-2023-sitc2023.0762","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0762","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1022
Juyeun Lee, Michael Nicosia, Ellen Hong, Daniel Silver, Cathy Li, Justin Lathia
{"title":"1022 Sex-biased T cell exhaustion drives differential immune responses in glioblastoma","authors":"Juyeun Lee, Michael Nicosia, Ellen Hong, Daniel Silver, Cathy Li, Justin Lathia","doi":"10.1136/jitc-2023-sitc2023.1022","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1022","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1287
Fredrick D Gootkind, Xinwei Sher, Keith Steele, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, Guy T Clifton, Laura A Dillon
{"title":"1287 Comparison of multiplex immunofluorescence and H&E-based approaches for characterization of the tumor microenvironment","authors":"Fredrick D Gootkind, Xinwei Sher, Keith Steele, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, Guy T Clifton, Laura A Dillon","doi":"10.1136/jitc-2023-sitc2023.1287","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1287","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0212
Leiam Colbert, Nicolas Fernandez, Hao Wang, Benjamin Patterson, Justin He, Jiang He
{"title":"212 Investigating cancer and immune cell interactions in the tumour microenvironment with MERFISH","authors":"Leiam Colbert, Nicolas Fernandez, Hao Wang, Benjamin Patterson, Justin He, Jiang He","doi":"10.1136/jitc-2023-sitc2023.0212","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0212","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0820
Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Christian Stocker, Alexander Rau, Kirsten Richter, Andreas Katopodis, Christoph Huber
{"title":"820 ANV600 is a novel PD-1 targeted IL-2Rβ/γ agonist that is combinable with therapeutic PD-1 inhibitors","authors":"Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Christian Stocker, Alexander Rau, Kirsten Richter, Andreas Katopodis, Christoph Huber","doi":"10.1136/jitc-2023-sitc2023.0820","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0820","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0516
Xinhua Wang, Oi Kwan Wong, Lei Shi, Qi Fei, Leonard Post, Xiaocheng Chen
{"title":"516 CD47 x B7-H3 bispecific antibody offers a new strategy for treating B7-H3<sup>+</sup>/CD47<sup>+</sup>tumors","authors":"Xinhua Wang, Oi Kwan Wong, Lei Shi, Qi Fei, Leonard Post, Xiaocheng Chen","doi":"10.1136/jitc-2023-sitc2023.0516","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0516","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1068
James F Sampson, Hong Zhang, Tomoya Hara, Dong Mei Zhang, Adam J Hinthorne, Sabrina C Collins, Michael D Curley
{"title":"1068 Evaluation of the innate and adaptive immune modulatory properties and anti-tumor activity of CD38-targeted interferon alpha","authors":"James F Sampson, Hong Zhang, Tomoya Hara, Dong Mei Zhang, Adam J Hinthorne, Sabrina C Collins, Michael D Curley","doi":"10.1136/jitc-2023-sitc2023.1068","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1068","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1023
Priyanka Manandhar, Emily Landy, Lawrence Kane
{"title":"1023 Cell-intrinsic Tim-3 is required for optimal CD8 response to acute LCMV infection","authors":"Priyanka Manandhar, Emily Landy, Lawrence Kane","doi":"10.1136/jitc-2023-sitc2023.1023","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1023","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1324
Ernest Philon, Daniel Johnson, Wesley Duerson, Graham Unis
{"title":"1324 The effect of antibiotic therapy on immunotherapy outcomes in the treatment of acquired bacterial infections during stage IV cancer treatment","authors":"Ernest Philon, Daniel Johnson, Wesley Duerson, Graham Unis","doi":"10.1136/jitc-2023-sitc2023.1324","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1324","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1138
Thomas Lisle, Maria Perez Penco, Morten Orebo Holmström, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen
{"title":"1138 TGFβ-specific T cells recognize megakaryocyte progenitors in patients with myeloproliferative neoplasms","authors":"Thomas Lisle, Maria Perez Penco, Morten Orebo Holmström, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen","doi":"10.1136/jitc-2023-sitc2023.1138","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1138","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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