Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0451
Jiaqiong Xu, Ethan Burns, Kelly Gee, Catherine Wiechmann, Yuqi Zhang, Ryan Kieser, Godsfavour Umoru, Shivan Shah, Kai Sun, Maen Abdelrahim, Abdullah Esmail
{"title":"451 Outcomes of patients with unresectable hepatocellular carcinoma who developed an infection while receiving Atezolizumab","authors":"Jiaqiong Xu, Ethan Burns, Kelly Gee, Catherine Wiechmann, Yuqi Zhang, Ryan Kieser, Godsfavour Umoru, Shivan Shah, Kai Sun, Maen Abdelrahim, Abdullah Esmail","doi":"10.1136/jitc-2023-sitc2023.0451","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0451","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1482
Kirsteen Maclean, Anna Juncker-Jensen, Qinqin Zha, Lakshmi Chandramohan
{"title":"1482 Spatial characterization of pro-inflammatory pathways in the pathogenesis of IBD-associated colorectal cancer","authors":"Kirsteen Maclean, Anna Juncker-Jensen, Qinqin Zha, Lakshmi Chandramohan","doi":"10.1136/jitc-2023-sitc2023.1482","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1482","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0959
Jun Chiang, Ace Santiago, Alexander Hermes, Anuj Patel, Benton Veire, David Sukovich, Hardeep Singh, Lauren Gutgesell, Stephen Williams, Augusto Tentori
{"title":"959 Multiomic characterization of the tumor microenvironment in FFPE tissue by simultaneous protein and gene expression profiling","authors":"Jun Chiang, Ace Santiago, Alexander Hermes, Anuj Patel, Benton Veire, David Sukovich, Hardeep Singh, Lauren Gutgesell, Stephen Williams, Augusto Tentori","doi":"10.1136/jitc-2023-sitc2023.0959","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0959","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0081
John G Foulke, Luping Chen, Hyeyoun Chang, Kevin M Tyo, Fang Tian, Zhizhan Gu
{"title":"81 Optimizing ex vivo CAR-T cell-mediated cytotoxicity assay through multimodality imaging","authors":"John G Foulke, Luping Chen, Hyeyoun Chang, Kevin M Tyo, Fang Tian, Zhizhan Gu","doi":"10.1136/jitc-2023-sitc2023.0081","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0081","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"1067 A three stage immune targeted immuno-cytokine platform that delivers inflammatory signals to the tumor microenvironment","authors":"Brian Rabinovich, Xueyuan Zhou, Jeffrey Takimoto, Nikhita Khanna, Sunny Yoon, Evren Alici","doi":"10.1136/jitc-2023-sitc2023.1067","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1067","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1315
Zhenqin Wu, James Zou, Aaron Mayer, Alexandro E Trevino
{"title":"1315 Identification and generalization of tissue structures with spatial cellular graph partitioning (SCGP)","authors":"Zhenqin Wu, James Zou, Aaron Mayer, Alexandro E Trevino","doi":"10.1136/jitc-2023-sitc2023.1315","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1315","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0259
Thomas J Gardner, Beatriz Millare, Anzhi Yao, Lan Chen, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela Boroughs, W Nicholas Haining
{"title":"259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity","authors":"Thomas J Gardner, Beatriz Millare, Anzhi Yao, Lan Chen, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela Boroughs, W Nicholas Haining","doi":"10.1136/jitc-2023-sitc2023.0259","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0259","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1494
Alanis Rodriguez Rosario, Fabio Henrique Brasil Da Costa, Nicholas Balbin, Roberto Rangel, Abdullah A Osman, Jeffrey N Myers, Andrew Sikora, Roberto Rangel
{"title":"1494 Role of gain of function p53 mutations in macrophage polarization and myeloid-derived suppressor cells in head and neck squamous cell carcinoma","authors":"Alanis Rodriguez Rosario, Fabio Henrique Brasil Da Costa, Nicholas Balbin, Roberto Rangel, Abdullah A Osman, Jeffrey N Myers, Andrew Sikora, Roberto Rangel","doi":"10.1136/jitc-2023-sitc2023.1494","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1494","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0640
Ecaterina Dumbrava, Bartosz Chmielowski, Dale Shepard, Daniel Vaena, Drew Rasco, Manish Sharma, Erika Hamilton, Kyriakos P Papadopoulos, Judy S Wang, Eran Ophir, Pierre Ferre, Inbal Barbiro, Gady Cojocaru, Adeboye H Adewoye, Manish Patel
{"title":"640 The combination of COM701 + nivolumab demonstrates preliminary antitumor activity in patients with metastatic breast cancer","authors":"Ecaterina Dumbrava, Bartosz Chmielowski, Dale Shepard, Daniel Vaena, Drew Rasco, Manish Sharma, Erika Hamilton, Kyriakos P Papadopoulos, Judy S Wang, Eran Ophir, Pierre Ferre, Inbal Barbiro, Gady Cojocaru, Adeboye H Adewoye, Manish Patel","doi":"10.1136/jitc-2023-sitc2023.0640","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0640","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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