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Treatment of anal fissures using the new TRPM8 receptor therapy - own experience. 使用 TRPM8 受体新疗法治疗肛裂--个人经验。
Pub Date : 2024-10-14 DOI: 10.5604/01.3001.0054.7946
Labib Zair, Dorota Zair, Szadi Zair, Katarzyna Zair-Mościbroda

<b>Introduction:</b> Anal fissure, a longitudinal or oval crack in the anal anoderm above the dentate line, is one of the most common diseases of the anal area. The following article shows the effectiveness of anal fissure treatment based on our own experience, using new receptor therapy in the form of Procto-Zac Memethol Barrier Spray [(1R,2S,5R)-2-isopropyl-5-methylcyclohexanol, sodium hydrogen carbonate, 7-(dimethylamino) phenothiazin-3-ylidene]- dimethylazanium; chloride, 1,2-propanediol, purified water], preparation containing soluble fiber and oral probiotic.<b>Aim:</b> The aim of the following article is to present our experience and observations in the conservative treatment of acute and chronic anal fissure using Procto-Zac Memethol Barrier Spray and preparations containing soluble fiber and oral probiotic.<b>Material and methods:</b> The study included a group of 120 patients with anal fissure between 18 and 45 years of age. Each patient in the group received a therapy consisting of Procto-Zac Memethol Barrier Spray (8 sprays once a day, 2 packages) and preparation containing fiber and oral probiotic. A high-fiber, gluten-free and lactose-free diet was also recommended. A follow-up was carried out in our clinic after 4 and 8 weeks. If the symptoms do not disappear completely, also after 3 months from the start of treatment.<b>Results:</b> Complete relief of symptoms was achieved in 62 patients after 4 weeks of treatment. After 8 weeks, complete relief of symptoms was achieved in another 49 people. In 6 people, after 3 months of treatment, the symptoms were partially relieved, but the anal fissure was not completely healed. Three people did not come for a follow-up visit. In 20 patients, skin burning around the anus was observed during the above therapy.The above symptoms did not require discontinuation of Procto-Zac Memethol Barrier Spray therapy and disappeared after completion of treatment. No other side effects of the preparations used were found.<b>Conclusions:</b> According to our observations, the use of new TRPM8 receptor therapy MemeThol Barrier Spray, a preparation containing soluble fiber and oral probiotic, turned out to be an effective method of treating anal fissure. In the future, it is advisable to conduct further studies, including multicenter studies, to assess the full tolerability and effectiveness of the described therapy.

<b>简介:</b> 肛裂是肛门齿状线以上肛门肛门真皮上的纵向或椭圆形裂缝,是肛门部位最常见的疾病之一。下文将根据我们的经验,介绍使用 Procto-Zac Memethol Barrier Spray[(1R,2S,5R)-2-异丙基-5-甲基环己醇、碳酸氢钠、7-(二甲基氨基)吩噻嗪-3-亚基]-二甲基铵; 氯化物、1,2-丙二醇、纯净水]、含可溶性纤维的制剂和口服益生菌的新受体疗法治疗肛裂的效果。<b>目的:</b>以下文章旨在介绍我们使用 Procto-Zac Memethol Barrier Spray 和含有可溶性纤维和口服益生菌的制剂保守治疗急慢性肛裂的经验和观察结果。组中的每位患者都接受了由 Procto-Zac Memethol 阻隔喷剂(每天一次,每次 8 喷,共 2 包)和含有纤维及口服益生菌的制剂组成的治疗。此外,还推荐了高纤维、无麸质和无乳糖饮食。4 周和 8 周后在本诊所进行随访。如果症状没有完全消失,也可在治疗开始 3 个月后进行复查。<b>结果:</b> 62 名患者在治疗 4 周后症状完全缓解。8 周后,另有 49 人的症状完全缓解。6 人在治疗 3 个月后,症状得到部分缓解,但肛裂未完全愈合。有 3 人没有来复诊。在上述治疗过程中,有 20 名患者的肛门周围皮肤出现灼烧感。上述症状无需停止 Procto-Zac Memethol Barrier Spray 的治疗,并在治疗结束后消失。没有发现所用制剂的其他副作用。<b>结论:</b> 根据我们的观察,使用 TRPM8 受体新疗法 MemeThol Barrier Spray(一种含有可溶性纤维和口服益生菌的制剂)是治疗肛裂的有效方法。今后,最好开展进一步的研究,包括多中心研究,以全面评估所述疗法的耐受性和有效性。
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引用次数: 0
Static reanimation of the paralyzed face using non-absorbable polypropylene mesh. 使用非吸收性聚丙烯网片对瘫痪的面部进行静态复位。
Pub Date : 2024-08-26 DOI: 10.5604/01.3001.0054.7167
Karolina Brzuszkiewicz, Piotr Drozdowski, Marta Handziak, Łukasz Łątkowski, Vladislav Lisovski, Katarzyna Kott, Ewa Łątkowska, Adam Turkus, Aleksander Jaworski, Ireneusz Łątkowski

<br><b>Introduction:</b> There are 2 methods for correcting facial deformities resulting from facial nerve paralysis - dynamic and static. Although dynamic methods are the standard approach in selected patient groups, static facial suspension using synthetic material provides a minimally invasive alternative for those who do not qualify for them.</br> <br><b>Aim:<b> Presenting experiences with the use of non-absorbable polypropylene mesh in the Department of Plastic Surgery in Polanica-Zdrój and reviewing the literature related to static facial reanimation methods.</br> <br><b>Materials and methods:</b> Fourteen patients underwent static facial tissue suspension using non-absorbable polypropylene mesh and 12 patients underwent surgery using classical autologous tissue techniques between 2019 and 2023. Indications for surgical treatment were analyzed, and preliminary results of treatment using both methods were compared.</br> <br><b>Results:</b> Compared to autologous tissue methods, surgeries using synthetic mesh were associated with shorter hospitalization times. No long-term postoperative complications were observed in any patient. There were no differences in treatment outcomes between autologous tissue and synthetic mesh techniques, and all patients assessed the outcome as favorable.</br> <br><b>Discussion:</b> Treatment of facial nerve paralysis sequelae using static techniques should be considered for patients not qualifying for surgery with dynamic methods and/or not consenting to such procedures. Using synthetic material as an alternative to autologous material reduces surgical time and avoids donor-site injuries and prolonged recovery.</br> <br><b>Conclusions:</b> Facial suspension with synthetic material is an effective, low-risk procedure for static correction of facial nerve paralysis sequelae.</br> <br><b>Study significance:</b> Emphasizing the importance of static methods in facial reanimation.</br>.

<br><b>简介:</b> 面神经麻痹导致的面部畸形有两种矫正方法--动态和静态。虽然动态方法是特定患者群体的标准方法,但使用合成材料的静态面部悬吊术为不符合条件的患者提供了一种微创替代方法。</br><br><b>目的:<b>介绍波兰兹罗伊整形外科使用非吸收聚丙烯网的经验,并回顾与静态面部复位方法相关的文献。</br><br><b>材料与方法:</b>2019年至2023年间,14名患者接受了使用不可吸收聚丙烯网的静态面部组织悬吊术,12名患者接受了使用经典自体组织技术的手术。对手术治疗的适应症进行了分析,并比较了两种方法的初步治疗结果。</br> <br><b>结果:</b> 与自体组织方法相比,使用合成网的手术住院时间更短。所有患者均未出现术后长期并发症。自体组织和合成网技术的治疗效果没有差异,所有患者都认为治疗效果良好。</br> <br><b>讨论:</b> 对于不符合动态方法手术条件和/或不同意接受此类手术的患者,应考虑使用静态技术治疗面神经麻痹后遗症。使用合成材料替代自体材料可缩短手术时间,避免供体部位损伤和恢复期延长。
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引用次数: 0
Mesenteric cysts. 肠系膜囊肿
Pub Date : 2024-08-21 DOI: 10.5604/01.3001.0054.7125
Evghenii Gutu, Igor Mishin, Vasile Guzun, Serghei Gutsu, Anna Mishina

<b>Introduction:</b> Mesenteric cysts (MCs) are a rare pathology of the abdominal cavity (with an incidence of 1/27.000 to 1/250.000 admissions) and less than 1000 cases have been described in the specialized literature.<b>Aim:</b> To identify the characteristics of clinical manifestations, diagnostics, and treatment of MCs.<b>Materials and methods:</b> Within 2001-2017, 17 consecutive patients with MCs were observed. Ultrasound scan (n = 17), computed tomography (n = 15), and magnetic resonance imaging (n = 1) were used to diagnose MC.<b>Results:</b> The mean age of patients with MCs was 43.4 3.5 years (range from 19 to 67), with a significant predominance of women (n = 14, 82.4%). The main clinical symptoms of MCs included abdominal pain (n = 9, 52.9%), pain + abdominal discomfort (n = 4, 23.5%), abdominal pain + nausea (n = 2, 11.8%), and abdominal discomfort (n = 2, 11.8%). In 13 (76%) cases, a palpable mass was noted in the abdominal cavity. According to imaging studies, the largest size of the MCs was 12.1 1.2 cm (from 5 to 20 cm) and the smallest - 8.6 0.8 cm (from 4 to 15 cm). The density of MC contents by computed tomography data varied from 2 to 26 HU. All patients underwent surgery via laparotomy. MCs were significantly more often located in the mesentery of the large bowel (n = 14, 82.4%) as compared to the small intestine (n = 3, 17.6%). The MCs of the small intestine in all cases were located in the mesentery of the jejunum, whereas in the colon lesions, they were distributed as follows: cecum (n = 1, 7.1%), ascending colon (n = 3, 21.4%), transverse colon (n = 7, 50%), and sigmoid colon (n = 3, 21.4%). Most MCs (n = 16, 94.1%) were enucleated, and only in one case segmental resection of small intestine with MCs was performed. The histopathological examination revealed: simple mesothelial MC - in 8 (47.1%), simple lymphatic MC - in 7 (41.2%), and lymphangioma - in 2 (11.7%) cases.<b>Conclusions:</b> MC is a rare pathology of abdominal organs. The clinical manifestations of MCs are nonspecific, and the final diagnosis becomes apparent only during surgery. In most cases, it is possible to perform MC enucleation without long-term recurrences.

<b>引言:</b>肠系膜囊肿(MCs)是一种罕见的腹腔病变(发病率为 1/27.000-1/250.000),专业文献中描述的病例不足 1000 例。<b>Aim:</b> To identify the characteristics of clinical manifestations, diagnostics, and treatment of MCs.<b>材料与方法:</b> 2001-2017年间,观察了17例连续的MC患者。超声扫描(17 例)、计算机断层扫描(15 例)和磁共振成像(1 例)被用于诊断 MC。<b>结果:</b> MCs 患者的平均年龄为 43.4 3.5 岁(19 岁至 67 岁不等),女性患者明显占多数(14 例,82.4%)。MCs 的主要临床症状包括腹痛(9 例,占 52.9%)、疼痛 + 腹部不适(4 例,占 23.5%)、腹痛 + 恶心(2 例,占 11.8%)和腹部不适(2 例,占 11.8%)。13例(76%)患者的腹腔内可触及肿块。根据影像学研究,MC 的最大尺寸为 12.1 1.2 厘米(从 5 厘米到 20 厘米不等),最小尺寸为 8.6 0.8 厘米(从 4 厘米到 15 厘米不等)。计算机断层扫描数据显示,MC内容物的密度从2到26 HU不等。所有患者都接受了开腹手术。与小肠(3 例,17.6%)相比,MC 明显更多位于大肠系膜(14 例,82.4%)。所有病例的小肠 MC 均位于空肠系膜,而结肠病变的 MC 分布如下:盲肠(1 个,7.1%)、升结肠(3 个,21.4%)、横结肠(7 个,50%)和乙状结肠(3 个,21.4%)。大多数 MCs(16 例,94.1%)被去核,只有一例患者进行了带有 MCs 的小肠节段切除术。组织病理学检查显示:8 例(47.1%)为单纯间皮 MC,7 例(41.2%)为单纯淋巴 MC,2 例(11.7%)为淋巴管瘤。MC 的临床表现无特异性,最终诊断只有在手术中才能显现。在大多数病例中,进行 MC 切除术后不会出现长期复发。
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引用次数: 0
Perioperative Elective Management in Patients Treated with Direct Oral Anticoagulants - Practical Guide. 直接口服抗凝药患者的围手术期选择性管理 - 实用指南》。
Pub Date : 2024-08-19 DOI: 10.5604/01.3001.0054.7091
Iwona Gorczyca-Głowacka, Piotr Wójcik, Łukasz Nawacki, Anna Tomaszuk-Kazberuk, Stanisław Głuszek

<b>Introduction:</b> Despite clear, relatively easy-to-use guidance, many clinicians find the perioperative management of direct oral anticoagulants (DOACs) challenging. Inappropriate antithrombotic management can delay procedures and lead to bleeding or thromboembolic complications.<b>Aim:</b> We aimed to describe perioperative management practices related to planned procedures regarding DOACs in accordance with the applicable guidelines of cardiological and surgical societies.<b>Results:</b> Perioperative management of DOAC therapy depends on many factors, and recommendations in the guidelines are not consistent.<b>Conclusions:</b> The best approach to managing these patients is therefore to strike a balance between the risks of bleeding and thromboembolism.

<b>引言:</b>尽管有明确、相对易用的指南,但许多临床医生发现直接口服抗凝药(DOACs)的围术期管理具有挑战性。</b>目的:</b>我们旨在根据心脏病学会和外科学会的适用指南,描述与计划手术有关的 DOACs 围手术期管理实践。<b>结果:</b>DOAC 治疗的围手术期管理取决于许多因素,指南中的建议并不一致。<b>结论:</b>因此,管理这些患者的最佳方法是在出血和血栓栓塞风险之间取得平衡。
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引用次数: 0
Delayed diagnosis, disease and secondary prevention, especially in young patients with colorectal cancer. 延迟诊断、疾病和二级预防,尤其是年轻的结直肠癌患者。
Pub Date : 2024-08-19 DOI: 10.5604/01.3001.0054.7120
Edyta Laska, Piotr Richter
<p><p><b>Introduction:</b> Colorectal cancer (CRC) is the third most common cancer worldwide and the second cause of death. Its incidence rate decreased by about 3% per year between 2011 and 2015, and mortality by 35% between 1990 and 2007. This improvement is a result of cancer prevention and early detection strategies through screening. The decline in cancer rates may have been due to a growing awareness of colorectal cancer in the Polish population. There was a discernible improvement in the quality of surgical treatment with time.<b>Aim:</b> The aim of the study was to determine the relationship between colonoscopy and the incidence of CRC, the incidence and family history of cancer and other intestinal diseases, as well as between the stage and time from first symptoms to the start of treatment.<b>Materials and methods:</b> A retrospective analysis of the records of patients with CRC treated surgically between 1995 and 2005 at the Department of General, Oncological, and Gastroenterological Surgery in Krakow and a diagnostic survey method were used.<b>Results:</b> There was a statistically significant relationship between the performance of colonoscopy and the incidence of CRC (P<0.001). There was no correlation between CRC and the incidence of cancer and other bowel diseases in the family, or between the stage and the time from first symptoms to the start of treatment. The length of time was long, usually up to 6 months, 1-3 years, and in some cases longer than 6 years.<b>Discussion:</b> Unfortunately, the incidence of CRC in young people under 50 years (EOCRC) has increased. Screening is of proven importance in reducing the incidence and mortality of CRC and every effort should be made to carry out as many of these screenings as possible. The time between diagnosis and treatment should also be kept as short as possible. Recommendations for the timeframe from diagnosis to treatment of cancer exist in many countries. In Australia, guidelines for an optimal care pathway suggest a timeframe of up to 7-9 weeks, similar to the National Health Service UK guidelines in the UK. Timeliness of treatment is an important factor in cancer care, to assess the consequences of delays and disruptions in oncology care.<b>Conclusions:</b> The incidence of CRC was lowest among those who had prophylactic examinations - colonoscopies. Studies on secondary prevention have confirmed that there was poor diagnosis in this area, even though there were cases of CRC in the immediate family, so it is worth educating the public and encouraging them to have colonoscopies and take care of their health. The long time between the appearance of the first clinical symptoms and the start of treatment, which was presented in the study, is unfortunately associated with a worse prognosis, as any delay in starting treatment for oncology patients is unfavorable.<b>Significance of the research for the dev
<b>简介:</b> 大肠癌(CRC)是全球第三大常见癌症,也是第二大死亡原因。2011 年至 2015 年间,其发病率每年下降约 3%,1990 年至 2007 年间,其死亡率每年下降 35%。这一改善得益于癌症预防和通过筛查进行早期检测的策略。癌症发病率的下降可能是由于波兰人对结直肠癌的认识不断提高。随着时间的推移,手术治疗的质量也有了明显的提高。<b>目的:</b> 该研究旨在确定结肠镜检查与 CRC 发病率、癌症和其他肠道疾病的发病率和家族史之间的关系,以及分期和从首次出现症状到开始治疗的时间之间的关系。<b>材料和方法:</b>对 1995 年至 2005 年期间克拉科夫普外科、肿瘤外科和胃肠外科接受手术治疗的 CRC 患者的记录进行了回顾性分析,并采用了诊断调查法。<b>结果:</b>结肠镜检查和 CRC 发病率之间存在显著的统计学关系(P<0.001)。CRC 与家族中癌症和其他肠道疾病的发病率之间没有相关性,分期与首次出现症状到开始治疗的时间之间也没有相关性。时间长短不一,通常长达 6 个月、1-3 年,有的甚至超过 6 年。<b>讨论:</b> 不幸的是,50 岁以下年轻人的 CRC 发病率(EOCRC)有所增加。事实证明,筛查对于降低 CRC 发病率和死亡率非常重要,因此应尽一切努力开展尽可能多的筛查。诊断与治疗之间的时间也应尽可能缩短。许多国家都对癌症从诊断到治疗的时间框架提出了建议。在澳大利亚,最佳治疗路径指南建议的时间框架最长为 7-9 周,这与英国国民健康服务英国指南相似。治疗的及时性是癌症治疗中的一个重要因素,要评估肿瘤治疗延误和中断的后果。关于二级预防的研究证实,尽管直系亲属中有 CRC 病例,但这方面的诊断率却很低,因此值得对公众进行教育,鼓励他们进行结肠镜检查并关注自己的健康。研究显示,首次临床症状出现与开始治疗之间的时间间隔较长,不幸的是,这与预后较差有关,因为对肿瘤患者来说,任何延误开始治疗的情况都是不利的。研究对该领域发展的意义:</b> 强调了二级预防在预防 CRC 中的作用,以及教育公众抓住癌症的最初令人担忧的迹象并咨询医生的必要性。
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引用次数: 0
Prognostic importance of preoperative albumin-to-alkaline phosphatase ratio in colorectal cancer patients. 结直肠癌患者术前白蛋白与碱性磷酸酶比值的预后重要性。
Pub Date : 2024-08-12 DOI: 10.5604/01.3001.0054.7078
Mehmet Reşit Sönmez, Elif Tuncay, İsa Caner Aydin, Nurdan Bezir, Mehmet Torun, Orhan Uzun, Selçuk Gülmez, Erdal Polat, Mustafa Duman

<b>Introduction:</b> Colorectal cancer (CRC) prognosis is typically determined based on clinical stage and histopathological findings, yet patients with the same stage and histological structure can exhibit varying survival outcomes. This highlights the need for additional prognostic biomarkers. Serum biomarkers are gaining increasing significance due to their affordability and accessibility. The albumin-alkaline phosphatase ratio (AAPR) has been associated with prognosis in hepatocellular and gastric cancers, but its role in CRC remains underexplored.<b>Aim:</b> This study aimed to evaluate the effect of the albumin-alkaline phosphatase ratio (AAPR) on the prognosis of patients with colorectal cancer (CRC).<b>Material and method:</b> Data from 358 patients who had undergone surgery for CRC were analyzed retrospectively to identify factors that could predict overall survival (OS). The Roc-Curve test was applied to determine the power of the preoperative AAPR in predicting mortality. Kaplan Meier and log-rank tests were used to examine the survival times of the patients.<b>Results:</b> Our findings revealed that an albumin-alkaline phosphatase cut-off ratio above 0.67 predicted mortality with a sensitivity of 17.54% and a specificity of 92.22%. Although patients with a lower AAPR exhibited a slightly shorter mean survival time compared to those above the cut-off value, this difference did not reach statistical significance (P = .112).<b>Conclusions:</b> The results of this study did not provide evidence to support the AAPR as a potential prognostic factor in patients with colorectal cancer.

<b>引言:</b>结直肠癌(CRC)的预后通常是根据临床分期和组织病理学检查结果来确定的,然而具有相同分期和组织学结构的患者却会表现出不同的生存结果。这凸显了对其他预后生物标志物的需求。血清生物标志物因其价格低廉、易于获得而越来越重要。<b>目的:</b>本研究旨在评估白蛋白-碱性磷酸酶比值(AAPR)对结直肠癌(CRC)患者预后的影响。<b>材料与方法:</b>回顾性分析了 358 例接受手术治疗的 CRC 患者的数据,以确定可预测总生存期(OS)的因素。采用 Roc-Curve 检验确定术前 AAPR 预测死亡率的能力。我们的研究结果表明,白蛋白-碱性磷酸酶临界比值高于 0.67 可预测死亡率,其敏感性为 17.54%,特异性为 92.22%。虽然与高于临界值的患者相比,白蛋白-碱性磷酸酶临界值较低的患者平均生存时间稍短,但这一差异未达到统计学意义(P = .112)。
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引用次数: 0
Effect of artificial intelligence implementation to the latest generation 4K colonoscopy. 人工智能对最新一代 4K 结肠镜检查的影响。
Pub Date : 2024-08-02 DOI: 10.5604/01.3001.0054.6995
Zofia Orzeszko, Tomasz Gach, Paweł Bogacki, Beata Markowska, Rafal Solecki, Mirosław Szura
<p><p><b>Indroduction:</b> Colonoscopy is an acclaimed screening test to detect colorectal cancer (CRC). The most important quality indicators for colonoscopy are adenoma detection rate (ADR), cecal intubation rate (CIR), withdrawal time (WT), and bowel preparation (Boston Bowel Preparation Scale; BBPS). In modern endoscopy practice, the human eye is enhanced by highdefinition white-light visualization and advanced imaging technology. The main limitation of this procedure is the detection rate of suspicious lesions. The next generation of endoscopes with 4K resolution and computer-aided detection (CADe) based on artificial intelligence (AI) may be the next step to improve the quality of tests performed.<b>Aim:</b> The aim was to assess the effect of CADe implementation in the environment of the latest generation of endoscopes and 4K visualization in retrospective analysis.<b>Methods:</b> The study included 2,000 patients over 18 years old who underwent colonoscopy for various indications. Olympus Endo-Aid CADe AI system was used, together with the latest X1 series endoscope set using LED lighting and 4K ultra high-resolution technology. Group I consisted of 1,000 consecutive tests performed using Endo-Aid CADe, and group II the first 1,000 consecutive tests without the CADe system. ADR, Advanced adenoma detection rate (AADR), polyp detection rate (PDR), and mean polyp per patient score (MPP) were assessed in each group<b>Results:</b> A total of 2,000 participants were included in the analysis, divided into two groups regarding CADe implementation. The overall PDR was similar in the analyzed groups (AI: 46.7% <i>vs.</i> non-AI: 44.9%, P = 0.419). Both ADR (29.7 <i>vs.</i> 28.9%, P = 0.694) and AADR (6.9 <i>vs.</i> 7.1%, P = 0.861) changed unremarkably. However, a significant elevation in MPP was noted. The MPP rose from 0.85 in the non-AI group to 1.26 in the AI group (P<0.001). The comparative analysis conducted separately for each segment of the bowel revealed that PDR remarkably increased in the left colon (29.3 <i>vs.</i> 18.0%, P<0.001), with no difference for other segments and other parameters. Investigating the MPP separately in each segment showed a significant difference for the right colon (0.33 <i>vs.</i> 0.23, P = 0.032) and the left colon (0.47 <i>vs.</i> 0.28, P<0.001). When adjusted to bowel preparation the PDR and MPP were constantly higher in the AI group (29.3 <i>vs.</i> 19.0%, P<0.001, and 0.48 <i>vs.</i> 0.30, P<0.001, respectively). In addition, the significant impact of AI implementation on MPP faded in the right colon (0.33 <i>vs.</i> 0.24, P = 0.051) when compared with the overall analysis.<b>Conclusions:</b> Although recently published evidence is optimistic regarding AI efficiency in improving the quality of colonoscopy, the provided results
<b>简介:</b> 结肠镜检查是检测结肠直肠癌(CRC)的一种广受赞誉的筛查方法。结肠镜检查最重要的质量指标是腺瘤检出率(ADR)、盲肠插管率(CIR)、退出时间(WT)和肠道准备(波士顿肠道准备量表;BBPS)。在现代内窥镜检查实践中,高清白光可视化和先进的成像技术增强了人眼的功能。这种检查方法的主要局限性在于可疑病灶的检出率。下一代 4K 分辨率内窥镜和基于人工智能(AI)的计算机辅助检测(CADe)可能是提高检测质量的下一步。<b>目的:</b>旨在通过回顾性分析评估在最新一代内窥镜和4K可视化环境中实施CADe的效果。使用奥林巴斯Endo-Aid CADe AI系统和最新的X1系列内窥镜(采用LED照明和4K超高分辨率技术)。第一组包括使用Endo-Aid CADe连续进行的1,000次检查,第二组包括未使用CADe系统的前1,000次连续检查。每组评估 ADR、高级腺瘤检出率 (AADR)、息肉检出率 (PDR) 和每位患者息肉平均得分 (MPP)<b>结果:</b> 共有 2000 名参与者参与分析,根据 CADe 的实施情况分为两组。分析组的总体 PDR 相似(人工智能组:46.7% <i>vs.</i> 非人工智能组:44.9%,P = 0.419)。ADR(29.7% <i>vs.</i>28.9%,P = 0.694)和AADR(6.9% <i>vs.</i>7.1%,P = 0.861)均无明显变化。不过,MPP 有了明显的提高。MPP 从非 AI 组的 0.85 升至 AI 组的 1.26(P<0.001)。对每个肠段分别进行的比较分析表明,左结肠的 PDR 显著增加(29.3 <i>vs.</i> 18.0%,P<0.001),其他肠段和其他参数没有差异。对各节段的 MPP 分别进行调查后发现,右侧结肠(0.33 <i>vs.</i> 0.23,P = 0.032)和左侧结肠(0.47 <i>vs.</i> 0.28,P<0.001)的差异显著。根据肠道准备情况进行调整后,AI 组的 PDR 和 MPP 一直较高(分别为 29.3 <i>vs.</i> 19.0%, P<0.001 和 0.48 <i>vs.</i> 0.30, P<0.001)。此外,与整体分析相比,人工智能的实施对右侧结肠的 MPP 有明显影响(0.33<i>vs.</i> 0.24,P = 0.051)。前瞻性随机对照试验(RCT)包括使用最新一代结肠镜进行的手术,应能阐明人工智能在高分辨率结肠镜检查中的作用。
{"title":"Effect of artificial intelligence implementation to the latest generation 4K colonoscopy.","authors":"Zofia Orzeszko, Tomasz Gach, Paweł Bogacki, Beata Markowska, Rafal Solecki, Mirosław Szura","doi":"10.5604/01.3001.0054.6995","DOIUrl":"https://doi.org/10.5604/01.3001.0054.6995","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Indroduction:&lt;/b&gt; Colonoscopy is an acclaimed screening test to detect colorectal cancer (CRC). The most important quality indicators for colonoscopy are adenoma detection rate (ADR), cecal intubation rate (CIR), withdrawal time (WT), and bowel preparation (Boston Bowel Preparation Scale; BBPS). In modern endoscopy practice, the human eye is enhanced by highdefinition white-light visualization and advanced imaging technology. The main limitation of this procedure is the detection rate of suspicious lesions. The next generation of endoscopes with 4K resolution and computer-aided detection (CADe) based on artificial intelligence (AI) may be the next step to improve the quality of tests performed.&lt;b&gt;Aim:&lt;/b&gt; The aim was to assess the effect of CADe implementation in the environment of the latest generation of endoscopes and 4K visualization in retrospective analysis.&lt;b&gt;Methods:&lt;/b&gt; The study included 2,000 patients over 18 years old who underwent colonoscopy for various indications. Olympus Endo-Aid CADe AI system was used, together with the latest X1 series endoscope set using LED lighting and 4K ultra high-resolution technology. Group I consisted of 1,000 consecutive tests performed using Endo-Aid CADe, and group II the first 1,000 consecutive tests without the CADe system. ADR, Advanced adenoma detection rate (AADR), polyp detection rate (PDR), and mean polyp per patient score (MPP) were assessed in each group&lt;b&gt;Results:&lt;/b&gt; A total of 2,000 participants were included in the analysis, divided into two groups regarding CADe implementation. The overall PDR was similar in the analyzed groups (AI: 46.7% &lt;i&gt;vs.&lt;/i&gt; non-AI: 44.9%, P = 0.419). Both ADR (29.7 &lt;i&gt;vs.&lt;/i&gt; 28.9%, P = 0.694) and AADR (6.9 &lt;i&gt;vs.&lt;/i&gt; 7.1%, P = 0.861) changed unremarkably. However, a significant elevation in MPP was noted. The MPP rose from 0.85 in the non-AI group to 1.26 in the AI group (P&lt;0.001). The comparative analysis conducted separately for each segment of the bowel revealed that PDR remarkably increased in the left colon (29.3 &lt;i&gt;vs.&lt;/i&gt; 18.0%, P&lt;0.001), with no difference for other segments and other parameters. Investigating the MPP separately in each segment showed a significant difference for the right colon (0.33 &lt;i&gt;vs.&lt;/i&gt; 0.23, P = 0.032) and the left colon (0.47 &lt;i&gt;vs.&lt;/i&gt; 0.28, P&lt;0.001). When adjusted to bowel preparation the PDR and MPP were constantly higher in the AI group (29.3 &lt;i&gt;vs.&lt;/i&gt; 19.0%, P&lt;0.001, and 0.48 &lt;i&gt;vs.&lt;/i&gt; 0.30, P&lt;0.001, respectively). In addition, the significant impact of AI implementation on MPP faded in the right colon (0.33 &lt;i&gt;vs.&lt;/i&gt; 0.24, P = 0.051) when compared with the overall analysis.&lt;b&gt;Conclusions:&lt;/b&gt; Although recently published evidence is optimistic regarding AI efficiency in improving the quality of colonoscopy, the provided results","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"96 5","pages":"24-30"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-Rich Plasma: Characteristics and Current Review of its Use in Surgery. 富血小板血浆:富血小板血浆:特点及其在外科手术中的应用回顾。
Pub Date : 2024-07-09 DOI: 10.5604/01.3001.0054.6750
Šárka Odložilová, Jiri Paral, Miroslav Sirovy, Jan Zajak, Aleš Fibír

Platelet-rich plasma (PRP) is presently employed across various medical disciplines, including surgical specialties. It is primarily used in the healing of chronic wounds, burn medicine, tissue regeneration support, and scar correction as well as in other surgical and orthopedic indications. Wounds, in general, possess a pro-inflammatory biochemical environment characterized by high protease activity that diminishes the effective concentration of growth factors. In contrast, PRP serves as a source of growth factors and exhibits mitogenic, angiogenic, and chemotactic properties. PRP is a biological product defined as a portion of the autologous blood's plasma fraction with a higher than physiological platelet concentration. PRP is obtained through the centrifugation of blood samples collected from patients. The insights into the biology, mechanism of action, and classification of PRP presented in this review can assist medical professionals in orienting themselves and comprehending the possibilities of the clinical application of this therapy, which remains a subject of investigation and validation. This review summarizes up-to-date information regarding the use of PRP, primarily in burn and reconstructive surgery, plastic surgery, traumatology, and general surgery.

富血小板血浆(PRP)目前被广泛应用于各个医学学科,包括外科专科。它主要用于慢性伤口愈合、烧伤治疗、组织再生支持、疤痕矫正以及其他外科和整形适应症。一般来说,伤口具有促炎的生化环境,其特点是蛋白酶活性高,会降低生长因子的有效浓度。与此相反,PRP 可作为生长因子的来源,并具有有丝分裂、血管生成和趋化特性。PRP 是一种生物制品,是指自体血液中血小板浓度高于生理浓度的血浆部分。PRP 是通过对从患者身上采集的血液样本进行离心分离而获得的。本综述介绍了 PRP 的生物学特性、作用机制和分类,有助于医疗专业人员确定方向,了解这种疗法在临床应用中的可能性。本综述总结了有关 PRP 应用的最新信息,主要涉及烧伤和重建外科、整形外科、创伤科和普通外科。
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引用次数: 0
Efficacy of joint denervation for degenerative disease of the joints in the hand: a review. 关节去神经治疗手部关节退行性疾病的疗效:综述。
Pub Date : 2024-07-09 DOI: 10.5604/01.3001.0054.6749
Andrzej Żyluk, Tomasz Mazurek, Bernard Piotuch

Osteoarthritis of the fingers and wrist, whether primary or secondary, is the most common degenerative disease. Its incidence is increasing due to the aging of the population. Most of the patients can be treated conservatively with good effect, but when conservative treatment fails, surgical intervention is considered. Essentially, there are 2 types of operations for this disease - radical (bone excision, arthrodesis, arthroplasty with an implant), and non-radical (joint denervation). Denervation of the joints has obvious advantages such as non-compromising the joint anatomy, preservation of range of motion, avoiding of an implant and low rate of complications. Denervation can be offered to younger patients, whatever their functional demands. Preservation of the bony anatomy does not preclude any further, more radical surgical interventions. This article presents a comprehensive information about methods of denervation of particular joints within the hand and their effectiveness in osteoarthritis. The current literature provides convincing evidence that denervation is a reliable and reproducible surgical technique for painful osteoarthritic conditions of the hand. It should be considered in patients presenting with painful joints which are still mobile, regardless the initial aetiology.

无论是原发性还是继发性,手指和手腕骨关节炎都是最常见的退行性疾病。随着人口老龄化的加剧,其发病率也在不断上升。大多数患者可以通过保守治疗获得良好效果,但当保守治疗无效时,就需要考虑手术治疗。从根本上说,治疗这种疾病的手术有两种--根治性手术(骨切除术、关节切除术、植入假体的关节成形术)和非根治性手术(关节去神经化)。关节去神经化具有明显的优势,如不破坏关节解剖结构、保留关节活动范围、避免植入假体以及并发症发生率低。无论患者的功能需求如何,都可以为年轻患者提供去神经支配治疗。保留骨骼解剖结构并不排除进一步采取更激进的手术干预措施。本文全面介绍了手部特定关节的去神经化方法及其对骨关节炎的疗效。目前的文献提供了令人信服的证据,证明去神经支配是治疗手部骨关节炎疼痛的一种可靠且可重复的外科技术。无论最初的病因是什么,关节疼痛但仍可活动的患者都应考虑使用该技术。
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引用次数: 0
The influence of supportive therapy with a six-component myophlebotropic preparation on the reduction of symptoms in patients with symptoms of hemorrhoidal disease. 使用六成分肌注制剂进行辅助治疗对减轻痔疮患者症状的影响。
Pub Date : 2024-06-24 DOI: 10.5604/01.3001.0054.6443
Anna Kwiatkowska, Maciej Borejsza-Wysocki, Michał Głyda, Anna Maria Pietrzak, Marek Szczepkowski, Andrzej Organ, Tomasz Banasiewicz

<b>Introduction:</b> Hemorrhoidal disease is the most common disease treated in proctology ambulatories. Conservative treatment is the basic form of treatment for this disease. One of the elements of treatment may be preparations with myoand phlebotropic effects.<b>Aim:</b> To assess the effect of a multi-ingredient myophlebotropic dietary supplement used as an adjunct on the rate and effectiveness of symptom relief in patients with stage II and III hemorrhoidal disease.<b>Material and method:</b> Patients with stage II and III hemorrhoidal disease with clinical symptoms such as pain, burning, itching and bleeding were qualified for the study. The patients were divided into two groups. The control group (Group I) of 29 patients receiving standard local treatment plus placebo and the study group (Group II) of 32 patients receiving the same local treatment and a six-component myophlebotropic product. Symptoms were analyzed at the time of inclusion in the study (day 0), after 4 and 10 days of therapy. The severity of hemorrhoidal disease and the feeling of relief were assessed on the day of inclusion (W0) and after 30 days of therapy.<b>Results:</b> There were no statistical differences between the groups in terms of disease advancement, age, gender, and duration of symptoms. Compared to the moment of inclusion in the study (W0), after 4 days (W1), after 10 days (W2) of taking the multi- -component product, there was a statistically significant improvement in the VAS scale: spontaneous pain and pain during defecation. In the qualitative assessment (yes/no), there were statistically significantly fewer cases of burning in the anus and itching. The treatment did not affect the rate of spontaneous bleeding, which was low at the beginning of the study, but significantly reduced the rate of bleeding during defecation. After 30 days of observation, it was found that the improvement in the severity of hemorrhoidal disease symptoms was significantly higher in the group using the tested preparation. Relief after a month of the study (one-question method) was noted in the group of patients receiving the tested product.<b>Conclusions:</b> The tested six-component myophlebotropic product proved to be effective in reducing the severity of symptoms such as spontaneous pain, pain during defecation, burning/burning in the anus and bleeding during defecation. Statistical significance was demonstrated in the symptom's relief and reduction in the severity of hemorrhoidal disease.

<b>引言:</b> 痔疮是肛肠科最常见的疾病。保守治疗是治疗这种疾病的基本方法。</b>目的:</b>评估作为辅助治疗的多成分肌注膳食补充剂对 II 期和 III 期痔疮患者症状缓解率和有效性的影响。<b>材料和方法:</b> 符合研究条件的Ⅱ期和Ⅲ期痔疮患者,临床症状为疼痛、灼热、瘙痒和出血。患者分为两组。对照组(I 组)29 名患者接受标准的局部治疗和安慰剂,研究组(II 组)32 名患者接受相同的局部治疗和六组分肌注产品。对纳入研究时(第 0 天)、治疗 4 天和 10 天后的症状进行了分析。在加入研究的当天(W0)和治疗 30 天后,对痔疮的严重程度和缓解感觉进行了评估。与加入研究时(W0)、服用多组分产品 4 天后(W1)和 10 天后(W2)相比,VAS 量表中的自发疼痛和排便时疼痛均有显著改善。在定性评估(是/否)中,肛门烧灼感和瘙痒的病例明显减少。自发性出血率在研究开始时很低,但治疗并未影响自发性出血率,但排便时的出血率明显降低。经过 30 天的观察发现,使用试验制剂的小组痔疮症状严重程度的改善程度明显更高。结论:</b> 经测试的六组分肌注产品可有效减轻自发疼痛、排便疼痛、肛门灼热/烧灼感和排便出血等症状的严重程度。在缓解症状和减轻痔疮严重程度方面具有统计学意义。
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引用次数: 0
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Polski przeglad chirurgiczny
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