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Bloodstream infections caused by Bacteroides and Phocaeicola: clinical relevance and antimicrobial susceptibility. Presentation of twenty-four cases. 拟杆菌和Phocaeicola引起的血流感染:临床相关性和抗菌药物敏感性。二十四例报告。
IF 0.7 Pub Date : 2025-11-21 DOI: 10.5604/01.3001.0055.4473
Marta Kierzkowska, Dariusz Kawecki, Edyta Podsiadły, Anna Majewska

Introduction: Anaerobic bloodstream infections caused by Gram-negative bacilli are rare, but the mortality rate remains high. Increasing resistance complicates treatment strategies. Aim: This study aimed to assess the clinical and microbiological characteristics of BSIs caused by Bacteroides spp. and related genera, and to evaluate the antibiotic susceptibility of isolated strains in adult patients hospitalized in a multidisciplinary Polish hospital over a 10-year period. Materials and methods: A retrospective, observational, single-center study included adult patients diagnosed with anaerobic BSIs between 2014 and 2023. Microbiological identification was performed using MALDI-TOF MS. Antimicrobial susceptibility was evaluated via gradient diffusion assay and interpreted according to EUCAST. Results: Anaerobic BSIs caused by Bacteroides spp. and Phocaeicola spp. were identified in 24 patients (mean age: 65.6 years). B. fragilis was the most common isolate (62.5%). Mortality among these hospitalized patients was 46%, with a significantly higher risk observed in elderly patients (median age of deceased: 83 years). All isolates were susceptible to metronidazole and carbapenems; 25% showed resistance to clindamycin. Discussion: The study confirmed high mortality, significant age-related risk, and variable antimicrobial susceptibility. Notably, Bacteroides-related BSIs often originated from gastrointestinal and urinary sources and were associated with chronic comorbidities, including renal failure. Conclusions: Empirical treatment regimens must consider increasing resistance among anaerobes. Timely microbiological diagnostics, including anaerobic cultures and susceptibility testing, are essential to guide therapy and improve patient outcomes. Significance: This study underscores the necessity for ongoing surveillance of anaerobic BSIs and highlights gaps in empirical treatment practices, advocating for broader clinical awareness and targeted antimicrobial stewardship.

革兰氏阴性杆菌引起的厌氧血流感染很少见,但死亡率仍然很高。耐药增加使治疗策略复杂化。目的:<;/b>;本研究旨在评估<;i>Bacteroides</i> sp .及相关属引起的bsi的临床和微生物学特征,并评估10年来波兰一家多学科医院住院的成年患者分离菌株的抗生素敏感性。材料和方法:<;/b>;单中心研究纳入了2014年至2023年间诊断为厌氧BSIs的成年患者。微生物学鉴定采用MALDI-TOF ms进行。通过梯度扩散法评估抗菌敏感性,并根据EUCAST进行解释。结果:由拟杆菌(bacteroides)和Phocaeicola (Phocaeicola)引起的厌氧BSIs。24例患者(平均年龄:65.6岁)。& lt; i> B。脆弱菌(Fragilis </i>)是最常见的分离菌(62.5%)。这些住院患者的死亡率为46%,老年患者的死亡率明显更高(死者中位年龄:83岁)。所有分离株对甲硝唑和碳青霉烯类敏感;25%的人对克林霉素耐药。讨论:<;/ >;研究证实了高死亡率、显著的年龄相关风险和不同的抗菌药物敏感性。值得注意的是,拟杆菌相关的bsi通常起源于胃肠道和泌尿系统,并伴有慢性合并症,包括肾衰竭。结论:经验性治疗方案必须考虑到厌氧菌的耐药性增加。及时的微生物诊断,包括厌氧培养和药敏试验,对于指导治疗和改善患者预后至关重要。意义:本研究强调了持续监测厌氧bsi的必要性,并强调了经验治疗实践中的差距,倡导更广泛的临床意识和有针对性的抗菌药物管理。
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引用次数: 0
The expression of genes KRAS, DPM1, ACRV1, and MBD3L2 in the saliva as potential tumor markers in the detection of pancreatic cancer. 唾液中KRAS、DPM1、ACRV1、MBD3L2基因表达作为胰腺癌潜在肿瘤标志物的研究
IF 0.7 Pub Date : 2025-11-13 DOI: 10.5604/01.3001.0055.4390
Jakub Ciosek, Daria Dranka-Bojarowska, Adam Lewiński, Paweł Lampe
<p><p><b>Introduction:</b> Pancreatic cancer is still an unresolved, significant diagnostic and clinical problem. An ideal tumor marker with a high sensitivity, organ specificity, and prognostic value that correlates with tumor stages and eliminates the imperfection of preoperative serum carbohydrate antigen 19-9 (CA 19-9) concentration is still being sought.<b>Aim:</b> This study aimed to conduct a comparative analysis expression of genes <i>KRAS, DPM1, ACRV1</i>, and <i>MBD3L2</i> in the saliva of patients with pancreatic cancer (PC) and a control group (CG).<b>Material and methods:</b> The study was performed on a group of 55 patients. Group 1 consisted of 44 patients with PC, group 2 (CG) consisted of 11 individuals who were recruited among patients operated on for non-inflammatory cholelithiasis. Group 1 was divided into 2 subgroups group 1a, 19 patients with resectable pancreatic tumors, and group 1b, 25 patients with unresectable pancreatic tumors. The saliva samples were taken from patients twice, before surgery and 10 days after surgery, and the expression of genes <i>KRAS, DPM1, ACRV1</i>, and <i>MBD3L2</i> in the saliva was evaluated. Gene expression at the transcriptional level was analyzed by assessing the number of mRNA copies using the reverse transcriptase reaction and polymerase chain reaction (RT-PCR).<b>Results:</b> The revealed expression of genetic cancer biomarkers (CB) (<i>KRAS, DPM1, ACRV1, MBD3L2</i>) in saliva was statistically significantly higher in the PC group in comparison to CG. There was a statistically significant decrease in the <i>KRAS</i> gene expression and a statistically significant increase in the <i>MBD3L2</i> expression in patients in subgroup 1a, 10 days after resection procedures. The revealed serum concentration of CA 19-9 was significantly higher in subgroup 1b in comparison to subgroup 1a. Although higher gene expression of <i>KRAS, DPM1</i>, and <i>MBD3L2 </i>was observed in subgroup 1b, no statistical significance was obtained. A statistically significant correlation between <i>DPM1</i> expression and serum CA 19-9 level in the PC group was observed. There were statistically significant differences in <i>KRAS </i>and <i>DPM1</i> expression depending on the tumor stage in the TNM/UICC classification regarding to T and N category. A significant difference in <i>MBD3L2</i> expression was observed in N category. A statistically significant increase in the expression of <i>KRAS, DPM1</i>, and <i>MBD3L2 </i>was observed in the case of neoplastic infiltration of blood vessels, and a significant increase in the expression of <i>KRAS</i> and <i>MBD3L2 <i/>in the case of neoplastic infiltration of nerve fibers.<b>Conclusions:</b> Presented findings
</b>;介绍:<;/b>;胰腺癌仍然是一个未解决的、重要的诊断和临床问题。目前仍在寻找一种理想的、与肿瘤分期相关的、具有高敏感性、器官特异性和预后价值的肿瘤标志物,并消除术前血清碳水化合物抗原19-9 (CA 19-9)浓度的缺陷。本研究旨在对KRAS、DPM1、acrv1基因的表达进行比较分析。胰腺癌患者(PC)和对照组(CG)唾液中MBD3L2<;/i>;材料和方法:<;/b>;研究对象为55例患者。第1组包括44名PC患者,第2组(CG)包括11名非炎症性胆石症患者。组1分为2个亚组,1a组可切除胰腺肿瘤19例,1b组不可切除胰腺肿瘤25例。术前和术后10天两次采集患者唾液,检测患者唾液中基因<;i>KRAS、DPM1、ACRV1</i>;和<;i>MBD3L2</i>;的表达情况。通过逆转录酶反应和聚合酶链反应(RT-PCR)检测mRNA拷贝数,分析基因在转录水平上的表达。< >;结果:<;/ >;与CG相比,PC组唾液中发现的基因癌生物标志物(CB) (<i>KRAS、DPM1、ACRV1、MBD3L2</i>)的表达有统计学意义。在切除手术后10天,亚组1a患者的<;i>KRAS</i>;基因表达有统计学意义降低,而<;i>MBD3L2</i>;表达有统计学意义升高。与1a亚组相比,1b亚组的血清CA 19-9浓度显著升高。虽然1b亚组中<;i>KRAS、<i> DPM1</i>;和<;i>MBD3L2 </i>;基因表达较高,但无统计学意义。PC组中<;i>DPM1</i>;表达与血清CA 19-9水平有统计学意义。在TNM/UICC分类中,T和N分类中,不同肿瘤分期的<;i>KRAS </i>;和<;i>DPM1</i>;表达差异有统计学意义。在N类中,MBD3L2</i>;的表达有显著差异。肿瘤浸润血管时,<i>KRAS、DPM1</i>;和<;i>MBD3L2 </i>;表达增加,具有统计学意义。在神经纤维肿瘤浸润的情况下,<i>KRAS</i>;和<;i>MBD3L2 <i/>;结论:<;/b>;目前的研究结果表明,唾液转录组谱在区分PC患者和健康对照者方面的有用性,但在可切除和不可切除PC的鉴别诊断方面的有用性有限。然而,需要更多的大规模人群研究来支持我们的结果。
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引用次数: 0
[72. Kongres Towarzystwa Chirurgów Polskich].
IF 0.7 Pub Date : 2025-10-22 DOI: 10.5604/01.3001.0055.3176
Wiesław Tarnowski

Z ogromną satysfakcją oddajemy do rąk Czytelników suplement Polskiego Przeglądu Chirurgicznego poświęcony72. Kongresowi Towarzystwa Chirurgów Polskich, który odbywa się w Warszawie w dniach 23-25 października 2025 roku.Jest to jedno z najważniejszych wydarzeń naukowych i integracyjnych środowiska chirurgicznego w Polsce, gromadzącezarówno uznanych ekspertów, jak i młodych badaczy oraz studentów zainteresowanych rozwojem tej dziedziny.

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引用次数: 0
Management of iatrogenic pseudoaneurysm - single-centre experience. 医源性假性动脉瘤的处理-单中心经验。
IF 0.7 Pub Date : 2025-10-15 DOI: 10.5604/01.3001.0055.3177
Karolina Mazurkiewicz, Łukasz Kruszyna, Szymon Markiewicz, Zbigniew Krasiński

<b>Introduction:</b> Iatrogenic pseudoaneurysms are uncommon but increasingly encountered complications due to the rising number of percutaneous interventions. For minor lesions, conservative treatment, such as pressure or observation, is often effective. However, its effectiveness depends on many factors, which do not always allow for avoiding surgical intervention.<b>Aim:</b> The aim of this study is to evaluate the diagnostic and therapeutic strategies for iatrogenic pseudoaneurysms based on a single-center experience, with emphasis on treatment efficacy, safety, and clinical outcomes.<b>Material and methods:</b> From 2021 to 2023, 57 patients underwent surgery for iatrogenic pseudoaneurysms at the Department of General and Vascular Surgery, Clinical Hospital in Poznan. Patients were retrospectively divided into two groups: with (n = 22) or without (n = 35) prior conservative treatment. Groups were compared regarding demographics, primary procedures, diagnostic tests performed, pseudoaneurysm features, vascular access, need for red blood cell transfusion (CRC), and outcomes.<b>Results:</b> No significant differences were found between groups in gender, BMI, smoking, prior endovascular interventions, or anticoagulant use (p > 0.05). Differences were observed in the primary procedures causing pseudoaneurysms (p < 0.05). Conservative treatment was more frequent after coronary angiography, ablation, and thrombolysis. Direct surgery without conservative attempts was associated with procedures like peripheral angioplasty, pacemaker or electrode implantation, TAVI, vascular access placement/removal, and aneurysm embolisation. In both groups, no statistically significant differences were found when comparing the type of diagnostic test performed (p>0.05). No significant differences were noted in pseudoaneurysm size, multicellularity, arteriovenous fistula presence, access type, transfusion needs, or treatment outcomes (p>0.05).<b>Conclusions:</b> Management should be individualized, considering patient history, prior interventions, pharmacotherapy, and imaging. Treatment should balance efficacy and safety, guided by clinical status.

医源性假性动脉瘤并不常见,但由于经皮介入治疗次数的增加,其并发症也越来越多。对于轻微的病变,保守治疗,如压迫或观察,通常是有效的。然而,其有效性取决于许多因素,这些因素并不总是允许避免手术干预。<b>;目的:<;/b>;本研究的目的是基于单中心经验评估医源性假性动脉瘤的诊断和治疗策略,重点是治疗有效性,安全性和临床结果。<b>;材料和方法:<;/b>;从2021年到2023年。57例患者在波兹南临床医院普通和血管外科接受了医源性假性动脉瘤手术。回顾性地将患者分为两组:接受过(n = 22)或未接受过(n = 35)保守治疗。各组在人口统计学、主要手术、进行的诊断试验、假性动脉瘤特征、血管通路、红细胞输注(CRC)需求和结局方面进行比较。结果:各组在性别、BMI、吸烟、既往血管内干预或抗凝剂使用方面无显著差异(p > 0.05)。在引起假性动脉瘤的主要手术中观察到差异(p < 0.05)。保守治疗在冠状动脉造影、消融和溶栓后更为常见。无保守尝试的直接手术与周围血管成形术、起搏器或电极植入、TAVI、血管通路放置/移除和动脉瘤栓塞等手术相关。两组比较诊断试验类型差异无统计学意义(p>0.05)。假性动脉瘤的大小、多细胞性、动静脉瘘的存在、通路类型、输血需求或治疗结果均无显著差异(p>0.05)。结论:治疗应个体化,考虑患者病史、既往干预、药物治疗和影像学。治疗应以临床情况为指导,兼顾疗效与安全性。
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引用次数: 0
Analysis of exercise tolerance in patients prior to and on day 2 after adrenalectomy on the basis of the six-minute walk test and the Borg scale. 基于6分钟步行测试和Borg量表的肾上腺切除术前和术后第2天患者运动耐量分析
IF 0.7 Pub Date : 2025-10-07 DOI: 10.5604/01.3001.0055.3077
Ewa Machała, Tomasz Aleksander Stępień, Krzysztof Kołomecki, Michał Kusiński

<b>Introduction:</b> The analysis of exercise tolerance and physical capacity plays a crucial role in the assessment of recovery and rehabilitation after surgery.<b>Aim:</b> The aim of the study was to assess physical capacity, exercise tolerance prior to and on day 2 after adrenalectomy on the basis of the six-minute walk test (6MWT) and Borg scale.<b>Material and methods:</b> The cohort study included 100 patients with adrenal tumors divided into the study group (SG,n = 50) and control group (CG, n = 50) who underwent adrenalectomy. SG patients met the criterion of inclusion: coexistingcardiovascular, respiratory, or other chronic diseases. The inclusion criteria for CG were the absence of other chronic systemiccomorbidities, age < 65 years. The 6MWT distance and Borg scale ratings (performed the day prior to and on the secondday after surgery) were analyzed according to the age, sex, comorbidities, adrenal and tumor size, hormonal type of adrenaldisease, type of surgery, and occurrence of postoperative complications.<b>Results:</b> Patients from SG covered significantly shorter distances (487.76 46.72 m in SG and 539.82 17.59 m in CG; p<0.001) anddemonstrated a higher level of exertion (p<0.001) before adrenalectomy and more often discontinued 6MWT after surgeries(p = 0.001) compared to CG. The authors confirmed a significant negative correlation between the age of the patients and sixminute walk distance (6MWD) before the operation in the study (rs = -0.40, p = 0.004) and control (rs = -0.74, p<0.001) groups.A significant decrease in the postoperative 6MWT distance (SG: to 231.35 4192 m, CG: to 236.82 54.10 m) and increasedintensity of dyspnea and fatigue according to the Borg scale were confirmed. SG patients were significantly more likely todevelop postoperative complications (p = 0.002).<b>Conclusions:</b> 6MWT is a useful tool to demonstrate physical capacity in patients before and after adrenalectomy. Patients with comorbidities more frequently discontinued 6MWT after surgery and had lower tolerance of physical effort compared to CG patients before and after surgery.

[lt;b>;]引言:<;/b>;运动耐量和身体能力的分析在手术后恢复和康复的评估中起着至关重要的作用。[lt;b>;]目的:<;/b>;以6分钟步行试验(6MWT)和Borg量表为基础,测定肾上腺切除术前和术后第2天的运动耐量。材料和方法:队列研究纳入100例肾上腺肿瘤患者,分为研究组(SG,n = 50)和对照组(CG, n = 50),均行肾上腺切除术。SG患者符合纳入标准:合并心血管、呼吸或其他慢性疾病。CG的纳入标准为无其他慢性全身合并症,年龄≥65岁。根据年龄、性别、合合症、肾上腺及肿瘤大小、肾上腺疾病的激素类型、手术类型、术后并发症的发生情况,分析6MWT距离和Borg评分(术前和术后第2天)。结果:SG组患者的距离明显较短(SG组487.76 46.72 m, CG组539.82 17.59 m;p<0.001),与CG相比,在肾上腺切除术前表现出更高水平的运动(p<0.001),手术后更经常停止6MWT (p = 0.001)。作者证实,在研究组(rs = -0.40, p = 0.004)和对照组(rs = -0.74, p<0.001)中,患者年龄与术前6分钟步行距离(6MWD)之间存在显著负相关。术后6MWT距离(SG:至231.35 4192 m, CG:至236.82 54.10 m)明显减少,Borg评分显示呼吸困难和疲劳强度增加。SG患者发生术后并发症的可能性显著增加(p = 0.002)。结论:6MWT是评估肾上腺切除术前后患者体能的有效工具。与CG患者相比,有合并症的患者在术后更频繁地停止6MWT治疗,并且在术前和术后对体力劳动的耐受性较低。
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引用次数: 0
Preoperative Botulinum Toxin A Injection in the Management of Giant Scrotal Hernia with Loss of Domain: A Volumetric and Clinical Case Study. 术前注射A型肉毒杆菌毒素治疗巨大阴囊疝伴区域丧失:体积和临床病例研究。
IF 0.7 Pub Date : 2025-10-07 DOI: 10.5604/01.3001.0055.3078
Mateusz Zamkowski, Katarzyna Szepietowska, Zuzanna Iwicka, Aleksandra Kondrusik, Wiktoria Korbut, Michał Putko, Maciej Śmietański

<b>Introduction:</b> Botulinum toxin type A (BTA) has emerged as a preoperative adjunct in complex ventral hernia repair, particularly in cases with loss of domain (LOD), yet volumetric evidence of its effect on abdominal wall geometry remains scarce.<b>Aim:</b> To evaluate the impact of BTA on abdominal cavity expansion and lateral muscle elongation in a patient with extreme LOD using volumetric computed tomography (CT) and geometric modeling.<b>Materials and methods:</b> A 61-year-old male with a giant left scrotal hernia and LOD (Tanaka index >25%) underwent BTA injections into the lateral abdominal wall, followed by CT imaging pre- and post-treatment. 3D reconstructions were generated to assess intra-abdominal volume and muscle lengths at three anatomical levels.<b>Results:</b> Abdominal cavity volume increased by 28.1% (13.74 L to 17.61 L), allowing safe visceral reintegration without abdominal compartment syndrome. The transversus abdominis exhibited the most pronounced elongation and volume gain (up to 329% elongation, 62% volume increase), while the external and internal obliques showed elongation with concurrent volume loss. The least elongation occurred at the costal level, highlighting anatomical rigidity in this region.<b>Discussion:</b> The results confirm that BTA-induced elongation varies by muscle and anatomical location. Minimal elongation at the subcostal level aligns with the known difficulty in closing M1-type hernias due to restricted superior abdominal wall mobility.<b>Conclusions:</b> BTA facilitated fascial closure by altering abdominal wall mechanics and increasing the intra-abdominal domain.<b>Significance:</b> This study is the first to combine volumetric and geometric modeling to objectively quantify BTA's mechanical impact, offering new insights into patient selection and planning for hernia repair with LOD.

A型肉毒杆菌毒素(BTA)已成为复杂腹疝修复的术前辅助药物,特别是在结构域丧失(LOD)的情况下。然而,关于其对腹壁几何形状影响的体积证据仍然很少。目的:<;/ >;利用体积计算机断层扫描(CT)和几何建模来评估BTA对极端LOD患者腹腔扩张和外侧肌肉延伸的影响。< >;材料和方法:<;/ >;一位61岁男性,患有巨大的左阴囊疝并LOD (Tanaka指数>;25%),接受BTA注射外侧腹壁。然后进行CT成像前后处理。结果:腹腔体积增加28.1% (13.74 L至17.61 L),使内脏安全融合,无腹膜间室综合征。腹横肌表现出最明显的伸长率和体积增加(伸长率高达329%,体积增加62%),而外斜肌和内斜肌则表现出伸长率和体积同时减少。最小的伸长发生在肋水平,突出了该区域的解剖刚性。讨论:<;/b>;结果证实,bta诱导的伸长因肌肉和解剖位置而异。肋下水平的最小延伸与已知的由于限制上腹壁活动而导致的m1型疝闭合困难相一致。结论:BTA通过改变腹壁力学和增加腹内区域来促进筋膜闭合。意义:<;/b>;本研究首次结合体积和几何建模来客观量化BTA的力学影响。为LOD疝修补术的患者选择和计划提供了新的见解。
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引用次数: 0
Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis. 腹腔镜腹膜灌洗与手术切除治疗复杂性穿孔性憩室炎:一项系统回顾和荟萃分析。
IF 0.7 Pub Date : 2025-09-01 DOI: 10.5604/01.3001.0055.2377
Mohamed AbdAlla Salman, Usama Shaker Mohamed, Ahmed Elewa, Mahmoud Ali, Amr Elserafy, Mohamed Tourky, Ahmed Salman

<b>Introduction:</b> Colonic diverticular disease (diverticulosis) is a currently worldwide increasing gastrointestinal disorder with a particularly high prevalence in Western countries. The operative treatment of acute diverticulitis could be executed through open or laparoscopic techniques. A non-resectional procedure, namely laparoscopic peritoneal lavage (LPL) and drainage, has also been adopted as a less invasive treatment strategy to treat patients with diverticular perforation and purulent peritonitis.<b>Aim:</b> The present work was conducted to pool the currently available evidence regarding the safety and efficacy of LPL for the treatment of complicated perforated diverticulitis.<b>Methods:</b> The analysis included studies that compared patients who underwent LPL to those who underwent surgical resection. Fifteen articles were eligible for this review after searching the Scopus, PubMed Central, Cochrane Library, and Google Scholar databases.<b>Results:</b> The meta-analysis demonstrated that operative time and blood loss were significantly lower in the LPL group (p<0.001). The rates of overall morbidity and reoperation were comparable in the two groups (p = 0.57 and 0.74, respectively). There were significantly lower rates of cardiovascular (p < 0.001) and respiratory complications (p = 0.01), incisional/parastomal hernia formation (p = 0.02), ICU admission (p < 0.001), length of hospital stay (p < 0.001), permanent stoma formation (p < 0.001), and mortality (p < 0.001), and higher rates of sepsis (p = 0.03), intra-abdominal abscess formation (p < 0.001), and postoperative recurrence (p < 0.001) in the LPL group.<b>Conclusions:</b> Compared to the colon resection procedures for the treatment of complicated diverticulitis, laparoscopic peritoneal lavage had comparable overall morbidity and reoperation rates and lower rates of permanent stoma formation and mortality. Still, there is concern regarding the recurrence and intra-abdominal abscess formation.

结肠憩室病(憩室病)是目前世界范围内日益严重的一种胃肠道疾病,在西方国家发病率特别高。急性憩室炎的手术治疗可通过开放或腹腔镜技术进行。非切除手术,即腹腔镜腹膜灌洗(LPL)和引流,也被作为一种微创治疗策略用于治疗憩室穿孔和化脓性腹膜炎。目的:<;/b>;本研究旨在收集目前可用的关于LPL治疗复杂性穿孔性憩室炎的安全性和有效性的证据。方法:<;/b>;该分析包括了比较LPL患者和手术切除患者的研究。在检索Scopus、PubMed Central、Cochrane Library和谷歌Scholar数据库后,有15篇文章入选本综述。结果:荟萃分析显示,LPL组的手术时间和出血量显著降低(p<0.001)。两组的总发病率和再手术率具有可比性(p分别为0.57和0.74)。心血管(p < 0.001)、呼吸系统并发症(p = 0.01)、切口/口旁疝形成(p = 0.02)、ICU入院率(p < 0.001)、住院时间(p < 0.001)、永久性造口形成(p < 0.001)和死亡率(p < 0.001)显著降低,脓毒症(p = 0.03)、腹内脓肿形成(p < 0.001)发生率较高。结论:与结肠切除术治疗复杂性憩室炎相比,腹腔镜下腹腔灌洗术的总发病率和再手术率相当,永久性造口率和死亡率更低。尽管如此,仍有关于复发和腹内脓肿形成的担忧。
{"title":"Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis.","authors":"Mohamed AbdAlla Salman, Usama Shaker Mohamed, Ahmed Elewa, Mahmoud Ali, Amr Elserafy, Mohamed Tourky, Ahmed Salman","doi":"10.5604/01.3001.0055.2377","DOIUrl":"10.5604/01.3001.0055.2377","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Colonic diverticular disease (diverticulosis) is a currently worldwide increasing gastrointestinal disorder with a particularly high prevalence in Western countries. The operative treatment of acute diverticulitis could be executed through open or laparoscopic techniques. A non-resectional procedure, namely laparoscopic peritoneal lavage (LPL) and drainage, has also been adopted as a less invasive treatment strategy to treat patients with diverticular perforation and purulent peritonitis.&lt;b&gt;Aim:&lt;/b&gt; The present work was conducted to pool the currently available evidence regarding the safety and efficacy of LPL for the treatment of complicated perforated diverticulitis.&lt;b&gt;Methods:&lt;/b&gt; The analysis included studies that compared patients who underwent LPL to those who underwent surgical resection. Fifteen articles were eligible for this review after searching the Scopus, PubMed Central, Cochrane Library, and Google Scholar databases.&lt;b&gt;Results:&lt;/b&gt; The meta-analysis demonstrated that operative time and blood loss were significantly lower in the LPL group (p&lt;0.001). The rates of overall morbidity and reoperation were comparable in the two groups (p = 0.57 and 0.74, respectively). There were significantly lower rates of cardiovascular (p &lt; 0.001) and respiratory complications (p = 0.01), incisional/parastomal hernia formation (p = 0.02), ICU admission (p &lt; 0.001), length of hospital stay (p &lt; 0.001), permanent stoma formation (p &lt; 0.001), and mortality (p &lt; 0.001), and higher rates of sepsis (p = 0.03), intra-abdominal abscess formation (p &lt; 0.001), and postoperative recurrence (p &lt; 0.001) in the LPL group.&lt;b&gt;Conclusions:&lt;/b&gt; Compared to the colon resection procedures for the treatment of complicated diverticulitis, laparoscopic peritoneal lavage had comparable overall morbidity and reoperation rates and lower rates of permanent stoma formation and mortality. Still, there is concern regarding the recurrence and intra-abdominal abscess formation.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 6","pages":"77-93"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of intestinal microflora in prehabilitation for colorectal cancer surgery - systematic review. 肠道菌群在结直肠癌手术前康复中的作用——系统综述。
IF 0.7 Pub Date : 2025-09-01 DOI: 10.5604/01.3001.0055.2587
Mateusz Prusisz, Jakub Włodarczyk, Inez Bilińska, Mateusz Porc, Kasper Maryńczak, Marcin Włodarczyk, Łukasz Dziki

Colorectal cancer (CRC) is a global health issue that frequently necessitates surgical treatment. Prehabilitation, a strategy designed to enhance patients' health status prior to surgery, has been recognized as an effective approach to improve surgical outcomes. Probiotics, celebrated for their positive impact on gut health, have been identified as a potential component of prehabilitation regimens for CRC patients. Nonetheless, the evidence supporting their efficacy in this setting is not yet definitive. This systematic review is intended to assess the role of probiotics in the prehabilitation of patients scheduled for colorectal cancer surgery.

结直肠癌(CRC)是一个全球性的健康问题,经常需要手术治疗。术前康复是一种旨在改善术前患者健康状况的策略,已被认为是改善手术结果的有效方法。益生菌因其对肠道健康的积极影响而闻名,已被确定为结直肠癌患者康复方案的潜在组成部分。尽管如此,在这种情况下支持其有效性的证据尚不明确。本系统综述旨在评估益生菌在结肠直肠癌手术患者康复中的作用。
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引用次数: 0
Advanced Protocols for Preoperative Colon Preparation: Enhancing Outcomes in Colorectal Surgery. 结肠术前准备的先进方案:提高结直肠手术的结果。
IF 0.7 Pub Date : 2025-08-12 DOI: 10.5604/01.3001.0055.2376
Marian Cerny, Ľudovít Danihel, Milan Schnorrer, Stefan Durdik

<b>Introduction:</b> Since the very beginnings of colorectal surgery, it has been dominated by the effort to reduce postoperative infectious complications and to find a way to prevent the risks associated with the dehiscence of intestinal anastomoses. Despite the technical, technological, and scientific advances achieved in medicine over the last decades, the mortality and morbidity figures in elective gastrointestinal surgery remain at a low, but relatively constant level. They continue to represent a problem that leads to an extension of treatment time, postoperative recovery, length of inpatient treatment, and thus increased expenses for the health system. One of the methods that was supposed to lead to a reduction in infectious complications was the introduction of mechanical cleaning of the large intestine before planned surgery 120 years ago. Successes in the treatment of infections with the help of discovered antibiotics were combined with their prophylactic administration, together with mechanical bowel preparation (MBP).<b>Aim:</b> The main aim was to find pros and cons of MBP in connection with postoperative complications.<b>Materials and methods:</b> In our prospective, international study, we compared a group of patients from 2 clinical sites. In Slovakia this was the 3<sup>rd</sup> Surgical Clinic, UNsP Merciful Brothers in Bratislava, and Klinikum Passau in Germany. A total of 418 patients with a benign or malignant colon disease who underwent elective resection were included in the study. Each center had its own preoperative colon preparation scheme. Patients were operated on by knowledgeable surgeons with at least 25 years of experience, either laparoscopically or conventionally. The monitored parameters were the type of operation, the execution of anastomoses, the conversion rate of laparoscopy to laparotomy, mortality, and morbidity. Postoperative complications were grouped into the following types: wound complications, intra-abdominal infections and anastomotic dehiscence, or the need for reoperation.<b>Conclusions:</b> We compared the obtained results with data from current world literature. With its conclusion, our study supported the currently prevailing opinion on mechanical cleansing of the large intestine, namely that it does not bring the desired effect on reducing perioperative infectious complications and dehiscence of anastomoses.

导语:<;/b>;自结直肠外科开始以来,一直以减少术后感染并发症和寻找预防肠吻合口破裂相关风险的方法为主导。尽管在过去的几十年里,医学在技术、工艺和科学方面取得了进步,但选择性胃肠手术的死亡率和发病率仍然保持在一个较低的水平,但相对稳定。它们仍然是一个问题,导致治疗时间延长、术后恢复、住院治疗时间延长,从而增加了卫生系统的费用。其中一种被认为可以减少感染并发症的方法是120年前在计划手术前引入的大肠机械清洁。我们将已发现的抗生素与预防性给药以及机械肠道准备(MBP)相结合,成功地治疗了感染。目的:<; >;目的:<;/ >;主要目的是找出MBP与术后并发症之间的利弊。< >;材料和方法:<;/ >;在我们前瞻性的国际研究中,我们比较了来自两个临床地点的一组患者。在斯洛伐克,这是3<;sup>rd< sup>;外科诊所,在布拉迪斯拉发的UNsP仁慈兄弟,以及在德国的Klinikum Passau。共有418名接受选择性结肠切除术的良性或恶性结肠疾病患者被纳入研究。各中心有自己的术前结肠准备方案。患者由至少有25年经验的专业外科医生进行手术,要么是腹腔镜手术,要么是常规手术。监测的参数包括手术类型、吻合口的执行情况、腹腔镜转开腹率、死亡率和发病率。术后并发症分为伤口并发症、腹腔内感染、吻合口裂开或需要再手术。结论:我们将所得结果与目前国际文献资料进行比较。本研究的结论支持了目前普遍认为机械清洗大肠在减少围手术期感染并发症和吻合口破裂方面效果不理想的观点。
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引用次数: 0
Research Trends on Post-ERCP Complications: Focus on Pancreatitis, Perforation, and Infections. ercp术后并发症的研究趋势:关注胰腺炎、穿孔和感染。
IF 0.7 Pub Date : 2025-08-12 DOI: 10.5604/01.3001.0055.2378
Jeffrey Ariesta Putra, Kartika Ratna Pertiwi

<b>Introduction:</b> Endoscopic retrograde cholangiopancreatography (ERCP) is widely used in the management of biliary andpancreatic disorders but carries a significant risk of complications, including post-ERCP pancreatitis (PEP), cholangitis,haemorrhage, and duodenal perforation. Despite technological advancements, these adverse events remain a global concern.A bibliometric analysis can elucidate publication trends, collaborative networks, and emerging themes in this evolving field.<b>Aim:</b> To analyze global research trends, authorship patterns, institutional and country contributions, and thematic shifts in post-ERCP complication research published between 2019 and 2025.<b>Methods:</b> A bibliometric analysis was conducted using the Scopus database. Articles and reviews in English, published between January 2019 and April 2025, were retrieved using a structured search strategy targeting ERCP complications. Data were analyzed using Microsoft Excel and VOSviewer (v1.6.20) to map publication trends, co-authorship networks, institutional output, country distribution, and keyword co-occurrence.<b>Results:</b> A total of 3,113 publications met the inclusion criteria. The number of articles increased steadily, peaking in 2024.The United States, Japan, and China were the most prolific contributors. "Post-ERCP pancreatitis" emerged as the dominanttheme, while recent years showed increasing focus on prevention, prediction models, and artificial intelligence. Collaborationwas highly centralised among high-income countries, with limited representation from low- and middle-income regions.<b>Conclusions:</b> Global research landscape on ERCP complications is expanding, with a shift towards data-driven and preventivestrategies. However, disparities in research quality, institutional dominance, and limited international inclusivity persist.Greater global collaboration and targeted capacity-building are essential to ensure equitable progress in ERCP safety andcomplication management.

内镜逆行胆管胰管造影(ERCP)广泛应用于胆道和胰腺疾病的治疗,但也存在显著的并发症风险,包括ERCP后胰腺炎(PEP)、胆管炎、出血和十二指肠穿孔。尽管技术进步,但这些不良事件仍然是全球关注的问题。文献计量学分析可以阐明这一不断发展的领域的出版趋势、合作网络和新兴主题。目标:<;/b>;分析2019年至2025年间发表的后ercp复杂性研究的全球研究趋势、作者模式、机构和国家贡献以及主题转变。方法:<;/b>;使用Scopus数据库进行文献计量学分析。使用针对ERCP并发症的结构化搜索策略检索2019年1月至2025年4月期间发表的英文文章和评论。使用Microsoft Excel和VOSviewer (v1.6.20)对数据进行分析,绘制出版趋势、合著网络、机构产出、国家分布和关键词共现情况。<b>;结果:<;/b>;共有3113篇出版物符合纳入标准。文章数量稳步增长,在2024年达到顶峰。美国、日本和中国是贡献最多的国家。“ercp后胰腺炎”成为主导主题,而近年来人们越来越关注预防、预测模型和人工智能。合作高度集中于高收入国家,低收入和中等收入地区的代表性有限。结论:ERCP并发症的全球研究格局正在扩大,并向数据驱动和预防策略转变。然而,在研究质量、机构主导地位和有限的国际包容性方面的差距仍然存在。加强全球合作和有针对性的能力建设对于确保在ERCP安全和并发症管理方面取得公平进展至关重要。
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引用次数: 0
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Polski przeglad chirurgiczny
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