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Application of the pedicled submental flap in the treatment of head and neck squamous cell carcinoma. 带蒂颏下皮瓣在头颈部鳞状细胞癌治疗中的应用。
Pub Date : 2025-03-12 DOI: 10.5604/01.3001.0055.0384
Cezary Szymczyk, Daniel Bula, Adam Maciejewski, Łukasz Krakowczyk, Janusz Wierzgoń, Dominik A Walczak

<b>Introduction:</b> The submental island flap, which is based on the submental vessels - the branches of the facial artery and vein - enables simple formation and relocation of the skin of this area.<b>Aim:</b> The goal of this study was a retrospective analysis of reconstructions in the head and neck region performed with pedicled submental flaps, including associated complications and oncological outcomes.<b>Material and methods:</b> A group of 15 patients with submental flap reconstruction (which was used to restore the continuity of the oral mucosa) was analyzed. All patients presented with locally low-advanced squamous cell carcinoma without nodal metastasis (T1-3, N0). The skin perforator was identified with a handheld Doppler device while raising the flap. The skin paddle was moved to the oral cavity. In all patients, the negative margins were confirmed by intraoperative frozen section histological analysis.<b>Results:</b> The vascular disturbances were found in two patients during the postoperative period. Complete flap loss was observed in one case, while in the other, 50% of the skin island became necrotic. Substitution of oral mucosa in the tongue, gum, or cheek with skin did not cause any problems. No significant disturbances in the mobility of the reconstructed tissues were noticed. The wound of the donor site healed without complications.<b>Conclusions:</b> The submental flap seems to be an interesting and uncomplicated reconstructive solution in the treatment of low-grade tumors of the oral cavity.

& lt; b>介绍:& lt; / b>颏下岛状皮瓣以颏下血管(面部动脉和静脉的分支)为基础,可以简单地形成和重新定位该区域的皮肤。本研究的目的是回顾性分析带蒂颏下皮瓣在头颈部进行的重建,包括相关并发症和肿瘤预后。材料和方法:<;/b>;本文对15例采用颏下皮瓣重建口腔黏膜的患者进行了分析。所有患者均表现为局部低晚期鳞状细胞癌,无淋巴结转移(T1-3, N0)。在抬高皮瓣的同时用手持式多普勒仪识别皮肤穿支。皮肤板移至口腔。所有患者术中冷冻切片组织学分析均证实阴性切缘。结果:2例患者术后出现血管紊乱。一例皮瓣完全丧失,另一例50%的皮肤岛坏死。用皮肤代替舌头、牙龈或脸颊的口腔黏膜不会引起任何问题。重建组织的移动性未见明显的干扰。供区创面愈合无并发症。结论:<;/b>;颏下皮瓣似乎是治疗低级别口腔肿瘤的一种有趣而简单的重建方法。
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引用次数: 0
iWOUND telemedicine application in the practice of the surgical department - who uses it? 远程医疗在外科实践中的应用——谁在使用它?
Pub Date : 2025-02-11 DOI: 10.5604/01.3001.0054.9904
Korneliusz Pieczyński, Krzysztof Karaś, Aneta Synakiewicz, Tomasz Banasiewicz

<b>Introduction:</b> Despite being a potentially avoidable complication, surgical site infection (SSI) remains the most common cause of postoperative complications in surgical wards. Timely medical consultation plays a crucial role in outpatient wound care when concerning symptoms related to wound healing arise. However, an excessive number of inpatient visits leads to a significant increase in patients attending general surgery clinics and the associated costs of postoperative care. Telemedicine (TM) may offer a solution to this problem. The iWound application facilitates wound healing monitoring and may aid in early detection of SSI symptoms.<br><br><b>Aim:</b> Therefore, this study aimed to characterize the group of patients utilizing the iWound application, conclusion of this analysis are included in this manuscript.<br><br><b>Materials and methods:</b> The study was conducted among adult patients who underwent either elective or emergency surgical procedures. Patients received access to the application during hospitalization for postoperative monitoring. Surveys regarding the use of the iWound application in the form of observation journals were conducted within 30 days postoperatively. The study does not bear the characteristics of a medical experiment, which was certified by the Bioethics Committee of the Poznań University of Medical Sciences, number 911/23.<br><br><b>Results:</b> The study included 104 participants aged 18-86 years, with 85.6% utilizing the application. The highest percentage of iWound users was observed in the 18-45 age group (94.4%). All participants who completed therapy with iWound reported satisfaction with its use during the recovery period. Four users developed SSI.<br><br><b>Conclusions:</b> The iWound application was most frequently utilized by younger individuals residing in urban areas and cigarette smokers. There was a higher percentage of willingness to use the application for postoperative wound monitoring among individuals undergoing major and emergency surgical procedures.

& lt; b>介绍:& lt; / b>尽管是一种潜在的可避免的并发症,手术部位感染(SSI)仍然是外科病房术后并发症的最常见原因。当出现与伤口愈合有关的症状时,及时的医疗咨询在门诊伤口护理中起着至关重要的作用。然而,过多的住院就诊导致到普通外科诊所就诊的患者和术后护理的相关费用显著增加。远程医疗(TM)可能为这个问题提供一个解决方案。iWound应用程序有助于伤口愈合监测,并可能有助于早期发现SSI症状。<;因此,本研究旨在对使用iWound应用的患者群体进行特征描述,并将分析结论纳入本文。<br>< < >;该研究是在接受选择性或紧急外科手术的成年患者中进行的。患者在住院期间可以使用该应用程序进行术后监测。术后30天内以观察日志的形式对iWound应用程序的使用情况进行调查。该研究不具有医学实验的特征,该特征已得到波兹纳斯医科大学生物伦理委员会的认证,编号911/23。<br><br>< & b>;结果:<;/b>;该研究包括104名年龄在18-86岁之间的参与者,其中85.6%的人使用该应用程序。18-45岁年龄组的iWound用户比例最高(94.4%)。所有完成iWound治疗的参与者在恢复期对其使用表示满意。四个用户开发了SSI.<br><br><b>;结论:<;/b>;iWound应用程序最常被居住在城市地区的年轻人和吸烟者使用。在接受重大和紧急外科手术的个体中,有较高比例的人愿意使用该应用程序进行术后伤口监测。
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引用次数: 0
Indocyanine green fluorescent imaging (ICG-FI) in esophagectomy: single-center experience. 吲哚菁绿荧光成像(ICG-FI)在食管切除术中的应用:单中心经验。
Pub Date : 2025-02-11 DOI: 10.5604/01.3001.0054.9779
Jakub Migoń, Michał Bąk, Maja Molska, Roman Lewandowski, Tomasz Piłat, Pawel Zielinski, Dawid Murawa

<b>Introduction:</b> Gold standard treatment for locally advanced esophageal cancer is subtotal resection of the esophagus with resection of regional lymph nodes. Despite being performed in experienced and specialized centers, this procedure is associated with a high rate of complications. Complications such as anastomotic fistula and leakage can be life-threatening, primarily resulting from inadequate blood circulation in the anastomosis area. <br><br><b>Aim:</b> The aim of the study is to present the results of intraoperative indocyanine green (ICG) application in order to verify the adequate perfusion in esophagogastric anastomosis. <br><br><b>Materials and methods:</b> This is a single-center prospective analysis of 32 patients who underwent subtotal esophagectomy with regional lymph node resection for esophageal carcinoma. In all cases, intraoperative perfusion assessment using ICG fluorescence imaging (ICG-FI) was performed. Patient characteristics, comorbidities, and postoperative outcomes were analyzed, with treatment effects monitored for up to 1 year postoperatively. <br><br><b>Results:</b> Six patients required gastric conduit reduction due to poor blood perfusion visualized by intraoperative ICG-FI. Anastomotic leakage occurred in two cases, which were managed endoscopically with endo-vac therapy and esophageal stent placement. The remaining patients did not require additional surgical interventions during the postoperative course. <br><br><b>Conclusions:</b> The use of ICG dye in esophageal surgery appears to be a beneficial tool for objective assessment of perfusion that may be a valuable prediction factor in the postoperative course.

& lt; b>介绍:& lt; / b>局部晚期食管癌的金标准治疗是食道次全切除术并切除区域淋巴结。尽管在经验丰富的专业中心进行,但该手术的并发症发生率很高。吻合口瘘和瘘等并发症可危及生命,主要是由吻合区血液循环不足引起的。& lt; br> & lt; br> & lt; b>目的:& lt; / b>本研究的目的是介绍术中吲哚菁绿(ICG)的应用结果,以验证食管胃吻合术中是否有足够的灌注。<br><br>< <;这是一项单中心前瞻性分析,对32例食管癌患者进行了次全食管切除术和区域淋巴结切除术。所有病例均采用ICG荧光成像(ICG- fi)进行术中灌注评估。分析患者特征、合并症和术后结果,并监测术后长达1年的治疗效果。& lt; br> & lt; br> & lt; b>结果:& lt; / b>6例患者因术中ICG-FI显示血液灌注不良,需要缩小胃导管。2例发生吻合口漏,均行内镜下食管内腔灌流治疗及食管支架置入术。其余患者在术后过程中不需要额外的手术干预。& lt; br> & lt; br> & lt; b>结论:& lt; / b>在食管手术中使用ICG染色是客观评估灌注的有益工具,可能是术后过程中有价值的预测因素。
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引用次数: 0
Tension faecopneumothorax: an analysis of a rare complication of a missed diaphragmatic injury. 张力性气胸:膈肌损伤漏诊的罕见并发症分析。
IF 0.7 Pub Date : 2025-02-11 DOI: 10.5604/01.3001.0054.9780
Mohammed Alfehaid, Sajad Ahmad Salati

<b>Introduction:</b> Tension faecopneumothorax (TFP) is a rare but potentially lethal complication of missed diaphragmatic injuries, wherein the herniated intestine perforates, releasing gas and faeces-contaminated fluids in the pleural cavity. This leads to an increase in the intrapleural pressure to levels that exceed the atmospheric pressure and results in adverse effects, which include mediastinal shift, kinking of the great vessels, reduced venous return, and cardiovascular collapse. <br><br><b>Aim:</b> This article was composed to review the profile of the cases of tension faecopneumothorax arising as a complication of missed diaphragmatic injuries, as reported in the recent literature. <br><br><b>Materials and methods:</b> A systematic literature search was conducted through electronic databases, including PubMed, Scopus, and Google Scholar, using the keywords and terms 'tension faecopneumothorax ', 'delayed diaphragmatic rupture', 'missed diaphragmatic injury', 'delayed tension faecopneumothorax', and 'traumatic diaphragmatic herniation'. Only literature in English was considered for inclusion in this study, and the time frame of 20 years was fixed between 2004 and 2024. <br><br><b>Results:</b> A total of 12 cases with a mean age of 45.2 years were included in the review. Abdominal pain, respiratory distress, and hemodynamic instability were the major presenting clinical features, manifesting acutely or gradually with sudden deterioration. All the hernias were left-sided and herniation of transverse colon was found in 11 (91.7%) cases. All the cases were managed by laparotomy with or without thoracotomy. There was one mortality and intensive care for variable periods was required in 4 (33.3%) cases. <br><br><b>Conclusions:</b> Tension faecopneumothorax is a rare and potentially lethal complication of missed diaphragmatic injuries that may appear even after years of trauma. This condition needs to be considered as a possible differential diagnosis, when a patient of sudden onset respiratory distress is being evaluated, particularly if there is a past history of blunt or penetrating abdominothoracic trauma.

张力性粪气胸(TFP)是一种罕见但潜在致命的膈肌漏伤并发症,其中疝出的肠穿孔,在胸膜腔中释放出气体和粪便污染的液体。这导致胸膜内压力升高到超过大气压的水平,并导致不良反应,包括纵隔移位、大血管扭结、静脉回流减少和心血管衰竭。< < < < <;目的:<;/ >;本文旨在回顾最近文献中报道的膈肌损伤漏报引起的张力性粪便气胸的病例概况。材料和方法:通过PubMed、Scopus和谷歌Scholar等电子数据库进行系统的文献检索,检索关键词和术语为“张力性气气胸”、“延迟性膈破裂”、“膈漏伤”、“延迟性张力性气气胸”和“创伤性膈疝”。本研究只考虑了英语文献,时间框架为2004年至2024年,为20年。结果:本研究共纳入12例患者,平均年龄45.2岁。腹痛、呼吸窘迫、血流动力学不稳定是主要的临床表现,表现为急性或逐渐恶化。所有病例均为左侧疝,其中横结肠疝11例(91.7%)。所有病例均行开腹或不开胸手术。1例死亡,4例(33.3%)需要不同时期的重症监护。结论:张力性气气胸是膈肌未损伤的一种罕见且潜在致命的并发症,即使在创伤多年后也可能出现。当对突发性呼吸窘迫患者进行评估时,尤其是既往有钝性或穿透性胸腹外伤史的患者,这种情况应被视为可能的鉴别诊断。
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引用次数: 0
The assesement of the long-term effects of kidney transplantation, including the incidence of malignant tumors, in recipients operated on between 2006 and 2015 - a cohort study and literature review. 2006年至2015年间肾移植受者的长期影响评估,包括恶性肿瘤的发生率——一项队列研究和文献综述。
Pub Date : 2025-01-22 DOI: 10.5604/01.3001.0054.9677
Wojciech Ciesielski, Weronika Frąk, Julita Gmitrzuk, Piotr Kuczyński, Tomasz Klimczak, Adam Durczyński, Janusz Strzelczyk, Piotr Hogendorf

<b>Introduction:</b> Chronic kidney disease (CKD) is a global public health problem, occurring more frequently in developed countries. In Poland, it affects approximately 4 million people, which constitutes 10.8% of the population. End-stage renal disease (ESRD) requires renal replacement therapy - dialysis therapy or kidney transplantation. Kidney transplantation, supported by immunosuppressive therapy, is the preferred method of treating ESRD, improving the quality and length of life of patients.<b>Aim and Methods:</b> The aim of the study was to determine the long-term effects of kidney transplantation, including proper graft function, the frequency of adverse effects of immunosuppressive therapy, the degree of patient compliance with therapeutic recommendations, and the incidence of malignancies. A survey was conducted in a group of 137 patients who underwent kidney transplantation between 2006 and 2015. Hospitalization data were also analyzed, including age, body weight and blood type of the recipient.<b>Results:</b> Of the 137 patients studied, 61 were women and 76 were men. The mean age of the patients was 45.1 years. The most common etiology of CKD was glomerulonephritis. After kidney transplantation, 86.86% of patients declared normal graft function. Post-transplant weight gain was noted in 75.18% of patients. 11.68% of recipients developed malignancies, with an average time from transplantation to diagnosis of 5.1 years. Of the patients with cancer, 93.75% maintained normal graft function.<b>Conclusions:</b> Long-term effects of kidney transplantation are satisfactory, with a high percentage of patients maintaining normal graft function. Complications associated with immunosuppressive therapy are comparable to literature data. It is necessary to increase patient awareness of modifiable risk factors to improve treatment outcomes. The incidence of malignancy after transplantation is lower than in the literature, but the methodological limitations of the study must be taken into account. Cancer treatment had no significant effect on graft function in most cases.

& lt; b>介绍:& lt; / b>慢性肾脏疾病(CKD)是一个全球性的公共卫生问题,多发于发达国家。在波兰,它影响了大约400万人,占人口的10.8%。终末期肾病(ESRD)需要肾脏替代治疗——透析治疗或肾移植。在免疫抑制治疗的支持下,肾移植是治疗终末期肾病的首选方法,可改善患者的生活质量和延长患者的生活时间。该研究的目的是确定肾移植的长期影响,包括适当的移植物功能,免疫抑制治疗不良反应的频率,患者对治疗建议的依从程度,以及恶性肿瘤的发生率。对2006年至2015年间接受肾移植的137名患者进行了一项调查。还分析了住院数据,包括患者的年龄、体重和血型。结果:<;/b>;在研究的137名患者中,61名女性,76名男性。患者平均年龄45.1岁。慢性肾脏病最常见的病因是肾小球肾炎。肾移植后,86.86%的患者宣称移植功能正常。移植后体重增加的患者占75.18%。11.68%的受者发生恶性肿瘤,从移植到诊断的平均时间为5.1年。在癌症患者中,93.75%的患者维持了正常的移植物功能。肾移植的长期效果是令人满意的,有很高比例的患者维持正常的移植物功能。与免疫抑制治疗相关的并发症与文献数据相当。有必要提高患者对可改变的危险因素的认识,以改善治疗结果。移植后恶性肿瘤的发生率低于文献,但必须考虑到研究方法的局限性。在大多数病例中,癌症治疗对移植物功能无显著影响。
{"title":"The assesement of the long-term effects of kidney transplantation, including the incidence of malignant tumors, in recipients operated on between 2006 and 2015 - a cohort study and literature review.","authors":"Wojciech Ciesielski, Weronika Frąk, Julita Gmitrzuk, Piotr Kuczyński, Tomasz Klimczak, Adam Durczyński, Janusz Strzelczyk, Piotr Hogendorf","doi":"10.5604/01.3001.0054.9677","DOIUrl":"https://doi.org/10.5604/01.3001.0054.9677","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Chronic kidney disease (CKD) is a global public health problem, occurring more frequently in developed countries. In Poland, it affects approximately 4 million people, which constitutes 10.8% of the population. End-stage renal disease (ESRD) requires renal replacement therapy - dialysis therapy or kidney transplantation. Kidney transplantation, supported by immunosuppressive therapy, is the preferred method of treating ESRD, improving the quality and length of life of patients.&lt;b&gt;Aim and Methods:&lt;/b&gt; The aim of the study was to determine the long-term effects of kidney transplantation, including proper graft function, the frequency of adverse effects of immunosuppressive therapy, the degree of patient compliance with therapeutic recommendations, and the incidence of malignancies. A survey was conducted in a group of 137 patients who underwent kidney transplantation between 2006 and 2015. Hospitalization data were also analyzed, including age, body weight and blood type of the recipient.&lt;b&gt;Results:&lt;/b&gt; Of the 137 patients studied, 61 were women and 76 were men. The mean age of the patients was 45.1 years. The most common etiology of CKD was glomerulonephritis. After kidney transplantation, 86.86% of patients declared normal graft function. Post-transplant weight gain was noted in 75.18% of patients. 11.68% of recipients developed malignancies, with an average time from transplantation to diagnosis of 5.1 years. Of the patients with cancer, 93.75% maintained normal graft function.&lt;b&gt;Conclusions:&lt;/b&gt; Long-term effects of kidney transplantation are satisfactory, with a high percentage of patients maintaining normal graft function. Complications associated with immunosuppressive therapy are comparable to literature data. It is necessary to increase patient awareness of modifiable risk factors to improve treatment outcomes. The incidence of malignancy after transplantation is lower than in the literature, but the methodological limitations of the study must be taken into account. Cancer treatment had no significant effect on graft function in most cases.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 2","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for postoperative morbidity after ventral hernia repair in patients with liver cirrhosis. A single tertiary center cohort. 肝硬化患者腹疝修补术后并发症的危险因素分析。单一三级中心队列。
Pub Date : 2024-12-13 DOI: 10.5604/01.3001.0054.9012
Dimitrios Prassas, Stephan Oliver David, Maria Chara Stylianidi, Apostolos Konstantinou, Wolfram Trudo Knoefel, Sascha Vaghiri

<b>Introduction:</b> Ventral hernias are common among patients with liver cirrhosis.<b>Aim:</b> The aim of our work was to evaluate potential risk factors for major postoperative morbidity after ventral hernia repair in cirrhotic patients.<b>Material and methods:</b> A retrospective cohort study was performed in 45 consecutive cirrhotic patients that underwent ventral hernia repair between 2005 and 2022. Major morbidity was defined as Clavien-Dindo ≥ IIIa at 30 days postoperatively. Uni- and multivariate analysis was performed to identify risk factors for major postoperative complications.<b>Results:</b> In our cohort, we observed an overall postoperative 30-day morbidity rate of 53.33% (n = 24), with 40% (n = 18) of cases classified as Clavien-Dindo IIIa or above. Elevated serum creatinine level preoperatively was identified as a statistically significant risk factor, both in the uni- as well as the multivariate analysis for major morbidity (OR = 31.08; 95%CI [29.51-32.65]; P = 0.028).<b>Conclusions:</b> Increased creatinine levels were found to be a significant modifiable factor for major morbidity after ventral hernia repair in cases with cirrhosis. This finding underlines the impact of preoperative medical management of cirrhotic patients on postoperative outcome in this patient population.

& lt; b>介绍:& lt; / b>腹疝在肝硬化患者中很常见。<b>;目的:<;/b>;我们的研究目的是评估肝硬化患者腹疝修补术后主要并发症的潜在危险因素。材料和方法:<;/ >;一项回顾性队列研究对2005年至2022年间连续接受腹疝修补术的45例肝硬化患者进行了研究。术后30天主要发病定义为Clavien-Dindo≥IIIa。进行单因素和多因素分析,以确定主要术后并发症的危险因素。在我们的队列中,我们观察到术后30天的总发病率为53.33% (n = 24),其中40% (n = 18)的病例分类为Clavien-Dindo IIIa或以上。术前血清肌酐水平升高被认为是具有统计学意义的危险因素,无论是在单因素分析还是多因素分析中都是如此(OR = 31.08;95%可信区间(29.51 - -32.65);P = 0.028).< >;肌酐水平升高被发现是肝硬化患者腹疝修补术后主要发病率的重要可改变因素。这一发现强调了肝硬化患者术前医疗管理对该患者群体术后预后的影响。
{"title":"Risk factors for postoperative morbidity after ventral hernia repair in patients with liver cirrhosis. A single tertiary center cohort.","authors":"Dimitrios Prassas, Stephan Oliver David, Maria Chara Stylianidi, Apostolos Konstantinou, Wolfram Trudo Knoefel, Sascha Vaghiri","doi":"10.5604/01.3001.0054.9012","DOIUrl":"https://doi.org/10.5604/01.3001.0054.9012","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Ventral hernias are common among patients with liver cirrhosis.&lt;b&gt;Aim:&lt;/b&gt; The aim of our work was to evaluate potential risk factors for major postoperative morbidity after ventral hernia repair in cirrhotic patients.&lt;b&gt;Material and methods:&lt;/b&gt; A retrospective cohort study was performed in 45 consecutive cirrhotic patients that underwent ventral hernia repair between 2005 and 2022. Major morbidity was defined as Clavien-Dindo ≥ IIIa at 30 days postoperatively. Uni- and multivariate analysis was performed to identify risk factors for major postoperative complications.&lt;b&gt;Results:&lt;/b&gt; In our cohort, we observed an overall postoperative 30-day morbidity rate of 53.33% (n = 24), with 40% (n = 18) of cases classified as Clavien-Dindo IIIa or above. Elevated serum creatinine level preoperatively was identified as a statistically significant risk factor, both in the uni- as well as the multivariate analysis for major morbidity (OR = 31.08; 95%CI [29.51-32.65]; P = 0.028).&lt;b&gt;Conclusions:&lt;/b&gt; Increased creatinine levels were found to be a significant modifiable factor for major morbidity after ventral hernia repair in cases with cirrhosis. This finding underlines the impact of preoperative medical management of cirrhotic patients on postoperative outcome in this patient population.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 2","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming Growth Factor-Beta (TGF-β) Dynamics in Thyroid Pathologies: A Comprehensive Analysis of Pre- and Post-Surgery Levels in Differentiated Thyroid Cancer and Nodular Goiter. 转化生长因子-β (TGF-β)在甲状腺病理中的动态:分化型甲状腺癌和结节性甲状腺肿术前和术后水平的综合分析。
Pub Date : 2024-11-22 DOI: 10.5604/01.3001.0054.8492
Adam Bednarczyk, Grzegorz Kowalski, Agata Gawrychowska, Jacek Gawrychowski

<b>Introduction:</b> In various pathological conditions, including cancer, transforming growth factor-beta (TGF-β) emerges as a pivotal cytokine.<b>Aim:</b> This study sought to evaluate TGF-β concentrations in blood serum samples and explore potential associations between pre- and post-surgery TGF-β levels in patients with differentiated thyroid cancer and forms of nodular goiter.<b>Material and methods:</b> A total of 70 patients were included, aged 26 to 79, undergoing thyroidectomy for: differentiated thyroid cancer (11), neutral nodular goiter (46), and hyperactive nodular goiter (13). Serum TGF-β1 values were assessed using the Bio-Plex Pro™ Human Cytokine Assay from Bio-Rad Laboratories, and data were analyzed with Bio-Plex Manager™ software.<b>Conclusions:</b> This investigation aimed to provide insights into the dynamics of TGF-β concentrations in the context of thyroid pathologies, utilizing a comparative approach before and after surgical intervention.

& lt; b>介绍:& lt; / b>在包括癌症在内的各种病理条件下,转化生长因子-β (TGF-β)作为关键的细胞因子出现。本研究旨在评估血清样本中TGF-β的浓度,并探讨分化型甲状腺癌患者手术前后TGF-β水平与结节性甲状腺肿形式之间的潜在关联。共纳入70例患者,年龄26 - 79岁,因分化性甲状腺癌(11例)、中性结节性甲状腺肿(46例)和过度活跃的结节性甲状腺肿(13例)行甲状腺切除术。使用Bio-Rad实验室的Bio-Plex Pro™人细胞因子测定法评估血清TGF-β1值,并使用Bio-Plex Manager™软件对数据进行分析。本研究旨在利用手术干预前后的比较方法,深入了解甲状腺病理背景下TGF-β浓度的动态变化。
{"title":"Transforming Growth Factor-Beta (TGF-β) Dynamics in Thyroid Pathologies: A Comprehensive Analysis of Pre- and Post-Surgery Levels in Differentiated Thyroid Cancer and Nodular Goiter.","authors":"Adam Bednarczyk, Grzegorz Kowalski, Agata Gawrychowska, Jacek Gawrychowski","doi":"10.5604/01.3001.0054.8492","DOIUrl":"https://doi.org/10.5604/01.3001.0054.8492","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; In various pathological conditions, including cancer, transforming growth factor-beta (TGF-β) emerges as a pivotal cytokine.&lt;b&gt;Aim:&lt;/b&gt; This study sought to evaluate TGF-β concentrations in blood serum samples and explore potential associations between pre- and post-surgery TGF-β levels in patients with differentiated thyroid cancer and forms of nodular goiter.&lt;b&gt;Material and methods:&lt;/b&gt; A total of 70 patients were included, aged 26 to 79, undergoing thyroidectomy for: differentiated thyroid cancer (11), neutral nodular goiter (46), and hyperactive nodular goiter (13). Serum TGF-β1 values were assessed using the Bio-Plex Pro™ Human Cytokine Assay from Bio-Rad Laboratories, and data were analyzed with Bio-Plex Manager™ software.&lt;b&gt;Conclusions:&lt;/b&gt; This investigation aimed to provide insights into the dynamics of TGF-β concentrations in the context of thyroid pathologies, utilizing a comparative approach before and after surgical intervention.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum expression of miR-200c-3p, miR-221-3p, and miR-222-3p as a diagnostic tool in papillary thyroid carcinoma - a preliminary study. 血清表达miR-200c-3p、miR-221-3p和miR-222-3p作为甲状腺乳头状癌诊断工具的初步研究
IF 0.7 Pub Date : 2024-11-21 DOI: 10.5604/01.3001.0054.8479
Damian Zadworny, Igor Bednarski, Julia Janiak, Michał Kusiński, Tomasz Stępień, Edyta Borkowska

<b>Introduction:</b> Papillary thyroid carcinoma (PTC) is the most common malignant thyroid cancer. However, its detection rateremains unsatisfactory. One of the most widely studied diagnostic methods in oncology is the use of microRNA (miR) molecules.Current literature indicates that miR-200c-3p, miR-221-3p, and miR-222-3p seem to be promising biomarkers of PTC.<b>Aim:</b> The aim of the study was to explore the usability of these circulating miRs as diagnostic biomarkers for PTC.<b>Materials and methods:</b> The study group (N = 20) included patients with post-operative histopathological confirmation of papillary thyroid carcinoma, while the control group (N = 10) consisted of patients who underwent thyroidectomy due to non-toxic nodular goiter (ntNG). A Real-Time PCR was used to assess the expression of each biomarker in blood serum.<b>Results:</b> The significant increase in miR-200c-3p expression in blood serum was observed among PTC patients (FC = 6.85)in comparison to controls (ntNG), while no significant differences were observed in the case of miR-221-3p and MiR-222-3pexpression between PTC and ntNG groups. The ROC curve analysis revealed that miR-200c-3p could be employed asa potential diagnostic tool in PTC.<b>Conclusions:</b> miR-200c-3p may have discriminative value in the diagnostics of PTC.

简介:<;/b>;甲状腺乳头状癌(PTC)是最常见的恶性甲状腺癌。然而,它的检出率仍然令人不满意。在肿瘤学中应用最广泛的诊断方法之一是使用microRNA (miR)分子。目前的文献表明,miR-200c-3p、miR-221-3p和miR-222-3p似乎是有希望的PTC生物标志物。目的:<; >;目的:<;/b>;本研究的目的是探讨这些循环mir作为PTC诊断生物标志物的可用性。材料和方法:<;/b>;研究组(N = 20)包括术后病理证实为甲状腺乳头状癌的患者;对照组(N = 10)为因无毒性结节性甲状腺肿(ntNG)行甲状腺切除术的患者。采用Real-Time PCR技术评估血清中各生物标志物的表达。<b>;结果:<;/b>;与对照组(ntNG)相比,PTC患者(FC = 6.85)血清中miR-200c-3p的表达显著升高,而PTC组和ntNG组之间miR-221-3p和mir -222-3p的表达无显著差异。ROC曲线分析显示miR-200c-3p可作为PTC的潜在诊断工具。结论:<;/b>; miR-200c-3p可能对PTC的诊断有鉴别价值。
{"title":"Serum expression of miR-200c-3p, miR-221-3p, and miR-222-3p as a diagnostic tool in papillary thyroid carcinoma - a preliminary study.","authors":"Damian Zadworny, Igor Bednarski, Julia Janiak, Michał Kusiński, Tomasz Stępień, Edyta Borkowska","doi":"10.5604/01.3001.0054.8479","DOIUrl":"https://doi.org/10.5604/01.3001.0054.8479","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Papillary thyroid carcinoma (PTC) is the most common malignant thyroid cancer. However, its detection rateremains unsatisfactory. One of the most widely studied diagnostic methods in oncology is the use of microRNA (miR) molecules.Current literature indicates that miR-200c-3p, miR-221-3p, and miR-222-3p seem to be promising biomarkers of PTC.&lt;b&gt;Aim:&lt;/b&gt; The aim of the study was to explore the usability of these circulating miRs as diagnostic biomarkers for PTC.&lt;b&gt;Materials and methods:&lt;/b&gt; The study group (N = 20) included patients with post-operative histopathological confirmation of papillary thyroid carcinoma, while the control group (N = 10) consisted of patients who underwent thyroidectomy due to non-toxic nodular goiter (ntNG). A Real-Time PCR was used to assess the expression of each biomarker in blood serum.&lt;b&gt;Results:&lt;/b&gt; The significant increase in miR-200c-3p expression in blood serum was observed among PTC patients (FC = 6.85)in comparison to controls (ntNG), while no significant differences were observed in the case of miR-221-3p and MiR-222-3pexpression between PTC and ntNG groups. The ROC curve analysis revealed that miR-200c-3p could be employed asa potential diagnostic tool in PTC.&lt;b&gt;Conclusions:&lt;/b&gt; miR-200c-3p may have discriminative value in the diagnostics of PTC.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 6","pages":"18-24"},"PeriodicalIF":0.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety enhancement in Nuss procedure: sternal elevation and thoracoscopic dissection. 提高Nuss手术的安全性:胸骨抬高和胸腔镜下的剥离。
Pub Date : 2024-11-20 DOI: 10.5604/01.3001.0054.8463
Mateusz Ciopiński, Michał Marciniak, Krzysztof Bogucki, Maciej Mitrowski, Weronika Chacińska, Paulina Chodnicka, Piotr Kaliciński

<b>Introduction:</b> <i>Pectus excavatum</i> (PE) is the most common chest wall deformity. Minimally invasive repair techniques based on the Nuss procedure are a mainstay of treatment. However, intraoperative cardiac injury, though rare, can be a devastating complication.<b>Aim:</b> This study aimed to evaluate a modification of the Nuss procedure designed to minimize the risk of serious complications.<b>Material and methods:</b> A retrospective analysis of medical records for 38 patients treated with a modified Nuss procedure forPE was conducted. The specific modifications to the surgical technique were described.<b>Results:</b> No intraoperative complications were observed in the analyzed patients. In 3 patients (7.9%), early complicationsafter surgery occurred, with none relating to the modification of the surgical technique.<b>Discussion:</b> Minimally invasive PE repair carries a risk of serious complications, prompting the development of variousmodifications. These modifications often involve techniques of sternal elevation and retrosternal dissection to achieve clearview throughout the procedure.<b>Conclusions:</b> The Nuss procedure with sternal elevation and thoracoscopic retrosternal dissection offers a simple andpotentially safer approach to PE repair.

& lt; b>介绍:& lt; / b>& lt; i>漏斗胸excavatum< / i>(PE)是最常见的胸壁畸形。基于Nuss程序的微创修复技术是治疗的主要方法。然而,术中心脏损伤虽然罕见,但可能是一种毁灭性的并发症。本研究旨在评估Nuss手术的一种改进,旨在将严重并发症的风险降至最低。材料和方法:<;回顾性分析了38例采用改良Nuss手术治疗pe的患者的医疗记录。对手术技术的具体修改进行了描述。结果:<;/b>;本组患者无术中并发症。3例(7.9%)患者术后出现早期并发症,与手术技术的改变无关。微创PE修复具有严重并发症的风险,促使各种改良的发展。这些改良通常涉及胸骨抬高和胸骨后剥离技术,以在整个手术过程中获得清晰的视野。胸骨抬高和胸腔镜胸骨后剥离的Nuss手术为PE修复提供了一种简单且可能更安全的方法。
{"title":"Safety enhancement in Nuss procedure: sternal elevation and thoracoscopic dissection.","authors":"Mateusz Ciopiński, Michał Marciniak, Krzysztof Bogucki, Maciej Mitrowski, Weronika Chacińska, Paulina Chodnicka, Piotr Kaliciński","doi":"10.5604/01.3001.0054.8463","DOIUrl":"https://doi.org/10.5604/01.3001.0054.8463","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; &lt;i&gt;Pectus excavatum&lt;/i&gt; (PE) is the most common chest wall deformity. Minimally invasive repair techniques based on the Nuss procedure are a mainstay of treatment. However, intraoperative cardiac injury, though rare, can be a devastating complication.&lt;b&gt;Aim:&lt;/b&gt; This study aimed to evaluate a modification of the Nuss procedure designed to minimize the risk of serious complications.&lt;b&gt;Material and methods:&lt;/b&gt; A retrospective analysis of medical records for 38 patients treated with a modified Nuss procedure forPE was conducted. The specific modifications to the surgical technique were described.&lt;b&gt;Results:&lt;/b&gt; No intraoperative complications were observed in the analyzed patients. In 3 patients (7.9%), early complicationsafter surgery occurred, with none relating to the modification of the surgical technique.&lt;b&gt;Discussion:&lt;/b&gt; Minimally invasive PE repair carries a risk of serious complications, prompting the development of variousmodifications. These modifications often involve techniques of sternal elevation and retrosternal dissection to achieve clearview throughout the procedure.&lt;b&gt;Conclusions:&lt;/b&gt; The Nuss procedure with sternal elevation and thoracoscopic retrosternal dissection offers a simple andpotentially safer approach to PE repair.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 2","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-year survival in laparoscopically operated colorectal cancer patients based on own material: A comparison of risk factors. 基于自身资料的腹腔镜结直肠癌患者5年生存率:危险因素的比较
Pub Date : 2024-11-05 DOI: 10.5604/01.3001.0054.8322
Mariusz Uryszek, Piotr Kwietniak, Agnieszka Iga Gonciarska, Wiesław Tarnowski

<b>Introduction:</b> The laparoscopic method is a treatment method with proven effectiveness. In 2008, we started treating patients with this method. We present treatment results in unselected patients. This is a retrospective observation.<b>Aim:</b> The present article demonstrates the results of a 5-year postoperative follow-up in a group of patients who underwent laparoscopic colorectal surgery. We also assessed the importance of basic risk factors such as tumor stage, age, gender, type of complication, and conversion requirement for the survival of patients.<b>Material and methods:</b> In total, 212 patients with colon or rectal cancer were subjected to a standard laparoscopic procedure. In the case of rectal and sigmoid tumors, a mini-laparotomy was performed in the left iliac fossa. In the case of right hemicolectomy, an anastomosis was created above the abdominal walls. The results were statistically processed. As many as 80% (171) of patients were followed up.<b>Results:</b> Overall survival was 66.08%, while cancer-related survival - 61.4%. The cancer recurrence rate was 21.47%. In a multivariate analysis: assuming the same age of diagnosis, an increase in tumor stage by one category according to Dukes causes a 102.532-fold increase in the risk of death within the first 5 years after surgery.<b>Conclusions:</b> The results of laparoscopic colorectal cancer treatment in our material are similar to those reported in the literature. The most important prognostic factor for the long-term survival of patients in our material was the stage of cancer.

& lt; b>介绍:& lt; / b>腹腔镜方法是一种被证明有效的治疗方法。2008年,我们开始用这种方法治疗病人。我们介绍了未选择患者的治疗结果。这是一项回顾性观察。目的:<;/b>;本文展示了一组接受腹腔镜结直肠手术的患者的5年术后随访结果。我们还评估了肿瘤分期、年龄、性别、并发症类型和转换要求等基本危险因素对患者生存的重要性。材料和方法:总共有212名结肠癌或直肠癌患者接受了标准的腹腔镜手术。在直肠和乙状结肠肿瘤的情况下,在左髂窝进行了小型剖腹手术。在右半结肠切除术的病例中,在腹壁上方建立吻合口。对结果进行统计学处理。多达80%(171)例患者随访。结果:<;/b>;总生存率为66.08%,而癌症相关生存率为61.4%。肿瘤复发率为21.47%。在一项多变量分析中:假设诊断年龄相同,根据Dukes,肿瘤分期每增加一个类别,术后前5年内死亡风险增加102.532倍。本材料中腹腔镜结直肠癌治疗的结果与文献报道的结果相似。在我们的材料中,对患者长期生存最重要的预后因素是癌症的分期。
{"title":"Five-year survival in laparoscopically operated colorectal cancer patients based on own material: A comparison of risk factors.","authors":"Mariusz Uryszek, Piotr Kwietniak, Agnieszka Iga Gonciarska, Wiesław Tarnowski","doi":"10.5604/01.3001.0054.8322","DOIUrl":"https://doi.org/10.5604/01.3001.0054.8322","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; The laparoscopic method is a treatment method with proven effectiveness. In 2008, we started treating patients with this method. We present treatment results in unselected patients. This is a retrospective observation.&lt;b&gt;Aim:&lt;/b&gt; The present article demonstrates the results of a 5-year postoperative follow-up in a group of patients who underwent laparoscopic colorectal surgery. We also assessed the importance of basic risk factors such as tumor stage, age, gender, type of complication, and conversion requirement for the survival of patients.&lt;b&gt;Material and methods:&lt;/b&gt; In total, 212 patients with colon or rectal cancer were subjected to a standard laparoscopic procedure. In the case of rectal and sigmoid tumors, a mini-laparotomy was performed in the left iliac fossa. In the case of right hemicolectomy, an anastomosis was created above the abdominal walls. The results were statistically processed. As many as 80% (171) of patients were followed up.&lt;b&gt;Results:&lt;/b&gt; Overall survival was 66.08%, while cancer-related survival - 61.4%. The cancer recurrence rate was 21.47%. In a multivariate analysis: assuming the same age of diagnosis, an increase in tumor stage by one category according to Dukes causes a 102.532-fold increase in the risk of death within the first 5 years after surgery.&lt;b&gt;Conclusions:&lt;/b&gt; The results of laparoscopic colorectal cancer treatment in our material are similar to those reported in the literature. The most important prognostic factor for the long-term survival of patients in our material was the stage of cancer.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"97 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Polski przeglad chirurgiczny
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