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Colostomy reversal after oncological resections versus non-oncological resections is not associated with worse postoperative outcomes - the results of the Polish Liquidation of Colostomy (LICO) study. 波兰结肠造口清理(LICO)研究结果显示,肿瘤切除后结肠造口逆转与非肿瘤切除后结肠造口逆转与更差的术后结果无关。
Pub Date : 2025-05-29 DOI: 10.5604/01.3001.0055.1391
Wojciech Wysocki, Michał Kisielewski, Natalia Dowgiałło-Gornowicz, Wiktor Krawczyk, Jakub Wantulok, Wojciech Serednicki, Mateusz Wierdak, Ignacy Oleszczuk, Ewa Grudzińska, Sławomir Mrowiec, Bartosz Molasy, Jacek Śmigielski, Tomasz Klimczak, Kamil Safiejko, Michał Wysocki, Karolina Richter, Tomasz Sachanbiński, Tomasz Wojewoda, Magdalena Pisarska-Adamczyk

<b>Introduction:</b> Colostomy reversal is a common surgical procedure following oncological and non-oncological resections. Colostomy reversal is performed in 60% in of non-oncological patients, and in only 40% of patients operated on for oncological reasons. Postoperative course as a possible reason for a lower colostomy reversal rate remains a controversial issue.<b>Aim:</b> To compare postoperative outcomes of colostomy reversal in patients with oncological versus non-oncological indications for colostomy creation.<b>Materials and methods:</b> The multicenter, prospective Liquidation of Colostomy (LICO) study was conducted in 20 surgical departments in Poland between October 2022 and December 2023. Patients were divided into two groups based on colostomy indication: oncological (Group 1) and non-oncological (Group 2). Primary outcomes were the length of hospital stay (LOS), postoperative complications, and 30-day reoperation rates.<b>Results:</b> Among 126 patients (46 in Group 1, 80 in Group 2), Group 1 patients were older (median 67 <i>vs.</i> 55.5 years, p<0.05) and had a higher prevalence of ischemic heart disease (32.6% <i>vs.</i> 10%, p = 0.002). Median LOS was 7 days for both groups (p = 0.656). Complication rates (34.8% in Group 1 <i>vs.</i> 43.8% in Group 2, p = 0.32) and reoperation rates (6.5% <i>vs.</i> 12.5%, p = 0.289) showed no significant differences. Intraoperative blood loss, operative times, and Clavien-Dindo complication grades were comparable between groups.<b>Discussion:</b> The results challenge the assumption that colostomy reversal after oncological resections carries higher risks. Comparable outcomes suggest perioperative care and patient selection are more critical than the underlying indication for colostomy.<b>Conclusions:</b> Colostomy reversal outcomes, including LOS, complications, and reoperations, were similar between oncological and non-oncological patients, supporting its safety in properly selected oncological cases without active disease.<b>Significance of the study:</b> This study provides evidence to guide clinical decision-making and refine guidelines, ultimately improving outcomes for patients undergoing colostomy reversal.

& lt; b>介绍:& lt; / b>结肠造口逆转是肿瘤和非肿瘤切除后常见的外科手术。60%的非肿瘤患者进行了结肠造口术逆转,而只有40%的患者因肿瘤原因进行了手术。术后过程是否可能是结肠造口逆转率较低的原因仍然是一个有争议的问题。比较肿瘤指征和非肿瘤指征结肠造口术患者的术后结果。材料和方法:<;/b>;多中心、前瞻性结肠造口清理(LICO)研究于2022年10月至2023年12月在波兰的20个外科部门进行。患者根据造口指征分为两组:肿瘤(1组)和非肿瘤(2组)。主要结局为住院时间(LOS)、术后并发症和30天再手术率。126例患者中(1组46例,2组80例),1组患者年龄较大(中位数为67 <;i>vs.</i>;55.5岁,p<0.05),缺血性心脏病患病率较高(32.6% <i>vs.</i>;10%, p = 0.002)。两组平均生存时间为7天(p = 0.656)。并发症发生率(1组<;i> 34.8% vs.</i>;第2组43.8%,p = 0.32),再手术率(6.5% <i>vs.</i>;12.5%, p = 0.289),差异无统计学意义。术中出血量、手术时间和Clavien-Dindo并发症分级在两组间具有可比性。结果挑战了肿瘤切除后结肠造口逆转具有更高风险的假设。可比较的结果表明,围手术期护理和患者选择比结肠造口的潜在指征更为关键。结肠造口术逆转的结果,包括LOS、并发症和再手术,在肿瘤和非肿瘤患者中是相似的,这支持了在适当选择的无活动性疾病的肿瘤病例中其安全性。本研究为指导临床决策和完善指南提供证据,最终改善结肠造口逆转患者的预后。
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引用次数: 0
Who is responsible for obtaining informed consent? A survey study. 谁负责获得知情同意?一项调查研究。
Pub Date : 2025-05-23 DOI: 10.5604/01.3001.0055.1344
Michał Gornowicz, Jakub Zięty, Mateusz Wityk, Paweł Lech, Natalia Dowgiałło-Gornowicz

<b>Introduction:</b> The process of obtaining informed consent for surgical procedures is a fundamental aspect of medical practice. However, it receive relatively little focus in medical literature. <br><br><b>Aim:</b> The aim of the study was to assess the practices of obtaining surgical consent across surgical specialties, with a special focus on general surgery. <br><br><b>Material and methods:</b> This was a survey study conducted among Polish surgical specialists and residents from October 1<sup>st</sup> to November 30<sup>th</sup>, 2024. The survey included 13 closed-ended questions covering demographic data, legal knowledge, and personal practices regarding informed consent. The survey was distributed via social media. <br><br><b>Results:</b> A total of 282 respondents participated in the survey. General surgeons made up the largest group (51.8%), followed by gynecologists (16.7%). Of the 11 surgical associations contacted, 4 confirmed that they provide consent forms for their members. More than half of the respondents (58.2%) were familiar with the current legal regulations on informed consent. The majority of surgeons (62.4%) reported providing information to patients themselves, although discrepancies in practice were noted, with residents and interns also involved in obtaining consent in some cases. Furthermore, only 12.4% of patients received the consent form during their pre-surgical qualification visit, with most patients seeing it the day before surgery. In 36.9% of cases, the operating surgeon was responsible for obtaining consent. <br><br><b>Conclusions:</b> The study highlights variations in practices regarding informed consent, with significant differences between specialties. The need for clearer legal frameworks and standardized procedures is emphasized to reduce legal risks and improve patient care.

& lt; b>介绍:& lt; / b>获得外科手术知情同意的过程是医疗实践的一个基本方面。然而,它在医学文献中受到的关注相对较少。& lt; br> & lt; br> & lt; b>目的:& lt; / b>该研究的目的是评估外科专科获得手术同意的做法,特别关注普外科。<br><br><b>;这是一项自10月1日起在波兰外科专家和住院医师中进行的调查研究。至2024年11月30日<; gt;日<;;该调查包括13个封闭式问题,涵盖人口统计数据、法律知识和知情同意方面的个人实践。该调查通过社交媒体发布。& lt; br> & lt; br> & lt; b>结果:& lt; / b>共有282名受访者参与了此次调查。普通外科医生占比最大(51.8%),其次是妇科医生(16.7%)。在我们联系的11个外科协会中,有4个证实它们为其成员提供了知情同意书。超过一半的受访者(58.2%)熟悉有关知情同意的现行法律规定。大多数外科医生(62.4%)报告自己向患者提供信息,尽管在实践中注意到差异,在某些情况下,住院医生和实习生也参与获得同意。此外,只有12.4%的患者在术前鉴定访问期间收到了同意书,大多数患者在手术前一天看到了同意书。在36.9%的病例中,手术医生负责征求同意。& lt; br> & lt; br> & lt; b>结论:& lt; / b>该研究强调了不同专业在知情同意实践方面的差异。强调需要更明确的法律框架和标准化程序,以减少法律风险和改善患者护理。
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引用次数: 0
Surgical techniques and the latest trends in surgical treatment of oesophageal cancer - a brief review. 食管癌手术治疗的外科技术和最新趋势-简要回顾。
IF 0.7 Pub Date : 2025-05-23 DOI: 10.5604/01.3001.0055.1346
Bartłomiej Strzelec, Piotr Paweł Chmielewski, Krzysztof Kurnol, Przemysław Dzierżek, Wojciech Kielan

<b>Introduction:</b> Oesophageal cancer is one of the leading causes of malignant death worldwide, and its incidence has increased sixfold in recent decades. Although it ranks sixth in mortality and eighth in incidence worldwide, it is one of the least understood and described cancers, which is probably related to its highly aggressive course and poor treatment outcomes.<b>Aim:</b> The aim of this study was to review the current literature regarding the treatment of oesophageal cancer.<b>Results:</b> Surgical treatment is the most important stage of therapy, and advances in this field and the development of new surgical techniques have significantly improved the five-year survival and reduced the incidence of postoperative complications. However, surgical treatment of oesophageal cancer is considered one of the most extensive and invasive procedures in cancer surgery, resulting in a steep learning curve for oesophageal resection procedures, especially minimally invasive (MI) techniques. Nevertheless, in the early stages of disease, oesophageal resection is the only currently accepted and used procedure that can potentially lead to a cure. The results of several studies comparing conventional and MI approaches have demonstrated the superiority of MI oesophagectomy, which is associated with fewer perioperative complications and inhospital deaths, shorter operation times, shorter intensive care unit stays, and higher quality of life rates. The learning curve for hybrid surgery, which bridges the gap between classic and MI procedures, is much shorter than for fully MI procedures, which is particularly appealing for surgeons who lack extensive experience in laparoscopy and thoracoscopy.<b>Conclusions:</b> In conclusion, given the clear advantages of MI techniques over classic techniques, we believe that despite a longer learning curve and more difficult surgical procedures, MI techniques should be the target techniques for treating oesophageal cancer.

导言:食管癌是全球恶性死亡的主要原因之一,近几十年来其发病率增加了六倍。虽然食管癌在全球死亡率排名第六,发病率排名第八,但它是人们了解和描述最少的癌症之一,这可能与食管癌病程极具侵袭性和治疗效果差有关。目的:<;/b>;本研究的目的是回顾目前有关食管癌治疗的文献。结果:<;/b>;手术治疗是治疗的最重要阶段。这一领域的进步和新的手术技术的发展显著提高了五年生存率,减少了术后并发症的发生率。然而,食管癌的手术治疗被认为是癌症外科中最广泛和最具侵入性的手术之一,导致食管癌切除术的学习曲线陡峭,特别是微创(MI)技术。然而,在疾病的早期阶段,食管切除术是目前唯一被接受和使用的可能导致治愈的手术。几项比较常规入路和心肌梗死入路的研究结果表明,心肌梗死食管癌切除术具有优势,其围手术期并发症和院内死亡较少,手术时间较短,重症监护病房住院时间较短,生活质量较高。混合手术的学习曲线弥补了传统和心肌梗死手术之间的差距,比完全心肌梗死手术的学习曲线要短得多,这对缺乏腹腔镜和胸腔镜经验的外科医生特别有吸引力。结论:总之,鉴于心肌梗死技术相对于传统技术的明显优势,我们认为尽管学习曲线更长,手术过程更困难,MI技术应成为食管癌治疗的目标技术。
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引用次数: 0
Reconstruction of the right side of the abdominal wall due to post-traumatic muscle avulsion. 由于创伤后肌肉撕脱造成右侧腹壁重建。
Pub Date : 2025-05-23 DOI: 10.5604/01.3001.0055.1345
Michał Putko, Mateusz Zamkowski, Maciej Śmietański

<b>Introduction:</b> Traumatic detachment of the lateral abdominal muscle group from the iliac crest occurs as a result of the acceleration mechanism when the body impacts a seatbelt during a head-on collision of motor vehicles. Due to the rare and variable nature of such defects, a standard treatment protocol has not yet been developed. As a result, the surgical technique and timing of the procedure are always planned individually. The optimal surgical method and type of implant for such cases remain undetermined. Given the anatomical location of the defect, surgical intervention utilizes techniques at the intersection of orthopaedics, reconstructive surgery, and herniology.<br><br><b>Aim:</b> Traumatic separation of the lateral abdominal muscles from the iliac crest, caused by blunt trauma, is a rare and complex injury. This study aims to present a novel surgical technique for managing such defects, focusing on the use of macroporous mesh fixation to the iliac crest with a ProTack stapler (Medtronic, Dublin, Ireland). <br><br><b>Materials and methods:</b> This paper describes the case of a patient with a traumatic detachment of the lateral abdominal muscle group from the iliac crest. The diagnosis was based on physical examination and computed tomography (CT). The surgery was performed 12 months after the initial injury and emergency surgical treatment of abdominal organs. Due to the size of the defect, an open approach was proposed. Adhesions were released, the preperitoneal space was dissected, and a macroporous implant measuring 26 × 28 cm was placed and fixed to the iliac crest using a ProTack stapler (Medtronic, Dublin, Ireland). The lateral abdominal muscles were reattached to the mesh to restore anatomical continuity. <br><br><b>Results:</b> Postoperatively, subcutaneous drainage was maintained for 9 days, and the use of a hernia belt was recommended continuously for 2 weeks, followed by 4 weeks during periods of increased physical activity. The patient was discharged on the third postoperative day. Primary wound healing and a satisfactory functional and aesthetic restoration of the abdominal wall were achieved. During a 12-month follow-up period, no hernia recurrence or other complications were observed. <br><br><b>Conclusions:</b> Traumatic detachment of the lateral abdominal muscle group is an extremely rare and serious medical condition. Randomized studies comparing approaches and surgical methods have not yet been conducted, and no standard treatment protocol has been established. The proposed treatment method, involving implant fixation to the bone using a stapler, appears to be a favorable therapeutic solution. Further experimental studies are needed to optimize the method and establish evidence-based guidelines.

& lt; b>介绍:& lt; / b>外伤性腹肌群脱离髂嵴的发生是由于加速机制,当身体撞击安全带在正面碰撞的机动车辆。由于这种缺陷的罕见性和多变性,目前还没有一个标准的治疗方案。因此,手术技术和手术时间总是单独计划的。对于此类病例,最佳的手术方法和植入物类型仍未确定。考虑到缺损的解剖位置,手术干预利用了骨科、重建外科和疝气学的交叉技术。<br>< < >;外伤性腹外肌与髂骨分离,是一种罕见而复杂的损伤。本研究旨在提出一种新的外科技术来处理这种缺陷,重点是使用ProTack订书机将大孔网固定在髂骨上(美敦力公司,都柏林,爱尔兰)。<br><br>< <;本文描述的情况下,病人外伤性脱离外侧腹肌群从髂骨。诊断基于体格检查和计算机断层扫描(CT)。手术是在初次损伤和腹部器官紧急手术治疗12个月后进行的。由于缺陷的大小,提出了一种开放的方法。解除粘连,切开腹膜前间隙,放置一个尺寸为26 × 28 cm的大孔植入物,使用ProTack吻合器(Medtronic, Dublin, Ireland)将其固定在髂骨上。将侧腹肌重新附着在补片上以恢复解剖连续性。& lt; br> & lt; br> & lt; b>结果:& lt; / b>术后维持皮下引流9天,建议连续使用疝带2周,随后在体力活动增加期间使用4周。患者于术后第三天出院。初步伤口愈合,腹壁的功能和美观恢复令人满意。随访12个月,未见疝复发及其他并发症。& lt; br> & lt; br> & lt; b>结论:& lt; / b>外伤性腹外肌群脱离是一种极其罕见和严重的医学状况。目前还没有比较入路和手术方法的随机研究,也没有建立标准的治疗方案。所提出的治疗方法,包括使用订书机将植入物固定在骨上,似乎是一种有利的治疗方案。需要进一步的实验研究来优化方法并建立循证指南。
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引用次数: 0
Management of early stages of Dupuytren's disease: a narrative review. 早期Dupuytren病的治疗:一个叙述性的回顾。
IF 0.7 Pub Date : 2025-05-14 DOI: 10.5604/01.3001.0055.1317
Andrzej Żyluk

<b>Introduction:</b> Dupuytren's disease is a common condition of the palmar aponeurosis, leding to contractures of the fingers. The disease onset is the formation of nodules in the palmar aponeurosis, which can be painful in some patients. Resection of the affected part of the palmar aponeurosis and release of finger contracture is a method of treating the advanced form of the disease, while in the early phase, awaiting progression has so far been recommended. Research presented over the past few years indicates the possibility of active treatment of early Dupuytren's disease to prevent the development of contractures.<b>Aim:</b> The aim of this article was a review of treatment modalities in the early Dupuytren's disease, mainly in terms of their efficacy, safety, and future perspectives.<b>Methods:</b> The current literature focusing on treatment modalities in early-stage Dupuytren's disease was reviewed.<b>Results:</b> To treat the early stage of the disease, various substances such as steroids, monoclonal antibodies, and <i>Clostridium histolyticum</i> collagenase were injected into the nodules. Radiotherapy and various methods of physical therapy were also used. The effectiveness of all these techniques was limited, although some, such as anti-TNF monoclonal antibody and radiotherapy, showed the ability to inhibit disease progression.<b>Conclusions:</b> Results of reviewed studies show that active treatment of the early stage of Dupuytren's disease has thepotential to prevent progression of finger contractures.

& lt; b>介绍:& lt; / b> Dupuytren'S疾病是掌腱膜的一种常见病症,可导致手指挛缩。本病的发病是掌腱膜形成结节,有些患者会感到疼痛。切除受影响的掌腱膜部分并解除手指挛缩是治疗晚期疾病的一种方法,而在早期阶段,迄今为止建议等待进展。过去几年的研究表明,积极治疗早期dupuytrens是可能的。目的:<;/b>;目的:<;/b>;对早期Dupuytren病的治疗方法进行综述,主要从疗效、安全性和未来前景方面进行综述。方法:<;/b>;结果:<;/b>;为了治疗早期Dupuytren病,使用类固醇、单克隆抗体、在结节内注射<;i>;胶原酶。放疗和各种物理治疗方法也被使用。所有这些技术的有效性都是有限的,尽管一些技术,如抗肿瘤坏死因子单克隆抗体和放疗,显示出抑制疾病进展的能力。结论:<;/ >;综述的研究结果表明,积极治疗早期Dupuytren病有可能预防手指挛缩的进展。
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引用次数: 0
The effectiveness of local steroid injection for the treatment of breast-limited idiopathic granulomatous mastitis: A randomized controlled clinical trial study. 局部类固醇注射治疗乳腺局限性特发性肉芽肿性乳腺炎的有效性:一项随机对照临床试验研究。
Pub Date : 2025-05-06 DOI: 10.5604/01.3001.0055.0956
Mohammad Yasin Karami, Morteza Amestejani, Vahid Zangouri, Zahra Habibagahi, Rahele Tavakoly, Aliyeh Ranjbar, Souzan Soufizadeh Balaneji, Seyed Amin Mousavi, Mahdiyeh Sadat Seyyedi, Sedigheh Tahmasebi, Somayyeh Hooshyar, Masoumeh Ghoddusi Johari, Alireza Golchini, Majid Akrami, Elham Halimi, Abdolrasoul Talei

<b>Introduction:</b> Idiopathic granulomatous mastitis (IGM) is a rare, non-specific inflammatory breast disease. There are severalcontroversies regarding its standard treatment.<b>Aim:</b> We aimed to evaluate the efficacy of local corticosteroid injection compared to systemic steroids and combined treatment of both in IGM patients.<b>Methods:</b> In this randomized controlled clinical trial study, 115 IGM patients were randomly allocated to three groups of localsteroid injection (Betamethasone, n = 37), systemic steroid treatment (Prednisolone + MTX, n = 37), or combined treatment ofboth (n = 41) for a follow-up period of 10 months. Clinical presentations and outcomes were compared between the groups.<b>Results:</b> The mean age of the study patients was 35.6 years. The mean time to complete remission was 3.17, 4.33, and 6.37 months, and the relapse rate during the treatment was 0%, 5.26%, and 13.33% in the injection, combined, and systemic therapy groups, respectively. There was no significant difference between the clinical response to treatment rate and the recurrence rate during the follow-up between the groups. Four patients in the combined therapy group and 3 patients in the systemic therapy group had steroid side effects, with no side effects in the injection group.<b>Conclusions:</b> Steroid injection therapy is more effective than combined therapy and systemic therapy in terms of remission and relapse rate during the treatment, and is as effective as systemic therapy in the clinical response to treatment rate and the recurrence rate during the follow-up period. Regarding the lack of side effects of the steroid injection therapy, this approach could be considered among the first-line treatment options.

& lt; b>介绍:& lt; / b>特发性肉芽肿性乳腺炎(IGM)是一种罕见的非特异性炎性乳腺疾病。关于其标准处理存在一些争议。我们的目的是评估IGM患者局部皮质类固醇注射与全身类固醇及两者联合治疗的疗效。在这项随机对照临床试验研究中,115例IGM患者被随机分为三组:局部类固醇注射(倍他米松,n = 37),全身类固醇治疗(强的松龙+ MTX, n = 37),或两者联合治疗(n = 41),随访10个月。比较两组患者的临床表现和预后。结果:<;/b>;研究患者的平均年龄为35.6岁。平均完全缓解时间为3.17个月、4.33个月、6.37个月,治疗期间复发率分别为0%、5.26%、13.33%。两组患者的临床有效率及随访复发率均无显著差异。联合治疗组4例、全身治疗组3例出现类固醇副作用,注射组无副作用。结论:在治疗期间的缓解率和复发率方面,类固醇注射治疗优于联合治疗和全身治疗,在治疗的临床反应率和随访期间的复发率方面,类固醇注射治疗与全身治疗同样有效。考虑到类固醇注射治疗缺乏副作用,这种方法可以被视为一线治疗方案之一。
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引用次数: 0
Nodular Histiocytic/Mesothelial Hyperplasia - not such a rare phenomenon in children with Spontaneous Pneumothorax. 结节性组织细胞/间皮增生——在儿童自发性气胸中并不罕见。
Pub Date : 2025-04-14 DOI: 10.5604/01.3001.0055.0864
Milosz Saryusz-Romiszewski, Damian Młynarski, Karolina Tokarska, Bartosz Bogusz, Wojciech Górecki

<b>Introduction:</b> Primary spontaneous pneumothorax (PSP) is a relatively rare condition in children, posing significantchallenges in its management and complicating efforts to identify those at higher risk of complications. Recent studieshave drawn attention to Nodular Histiocytic/Mesothelial Hyperplasia (NHMH) as an occasionally observed histologicalchange in this patient group. Differentiating NHMH from other potential neoplastic processes has become essential toensure accurate diagnosis and appropriate treatment.<b>Aim:</b> This study aimed to evaluate the frequency and clinical relevance of NHMH in pediatric patients with spontaneous pneumothorax at the Department of Pediatric Surgery in Cracow, Poland.<b>Materials and methods:</b> We conducted a retrospective re-analysis of histological images from patients who underwentsurgery for spontaneous pneumothorax between 2012 and 2024.<b>Results:</b> Our findings revealed a higher incidence of NHMH in patients who required reoperation after initial pneumothoraxtreatment.<b>Discussion:</b> The presence of NHMH, particularly in these cases of reoperation, suggests that chronic irritation of lung tissue, possibly due to the presence of emphysematous bullae, plays a significant role in its development.<b>Conclusions:</b> Recognizing NHMH in these patients is crucial for preventing misdiagnosis as a neoplastic process, which can have serious clinical implications.<b>Significance for the field:</b> Understanding this histological feature is important for guiding future therapeutic decisions andavoiding unnecessary interventions.

& lt; b>介绍:& lt; / b>原发性自发性气胸(PSP)在儿童中是一种相对罕见的疾病,对其治疗提出了重大挑战,并使识别那些并发症风险较高的努力复杂化。最近的研究引起了人们对结节性组织细胞/间皮增生(NHMH)的关注,因为它是该患者组中偶尔观察到的组织学变化。将NHMH与其他潜在的肿瘤过程区分开来对于确保准确诊断和适当治疗至关重要。本研究旨在评估波兰克拉科夫儿科外科儿童自发性气胸患者NHMH的频率和临床相关性。材料和方法:<;/b>;我们对2012年至2024年间接受自发性气胸手术的患者的组织学图像进行了回顾性再分析。我们的研究结果显示,在首次气胸治疗后需要再次手术的患者中,NHMH的发生率更高。NHMH的存在,特别是在这些再次手术的病例中,表明肺组织的慢性刺激,可能是由于肺气肿大泡的存在,在其发展中起重要作用。识别这些患者的NHMH对于防止误诊为肿瘤过程至关重要,这可能具有严重的临床意义。了解这一组织学特征对于指导未来的治疗决策和避免不必要的干预非常重要。
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引用次数: 0
Colorectal cancer: Application of selected liquid biopsy markers. 结直肠癌:选定液体活检标志物的应用。
Pub Date : 2025-03-25 DOI: 10.5604/01.3001.0055.0608
Maciej Skrzypek, Aleksandra Joanna Binda, Jacek Kabziński, Danuta Piotrzkowska, Mariola Głowacka, Łukasz Dziki, Adam Dziki, Ireneusz Majsterek

<b>Introduction:</b> Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide, creating a need for continuous search for innovative diagnostic and disease monitoring methods. Traditional techniques, although effective, are highly invasive and may be associated with risks for patients, which prompts the development of less invasive alternatives. One such method is liquid biopsy - a technique for analyzing circulating biomarkers in body fluids.<b>Aim:</b> This paper describes the use of liquid biopsy in both the diagnosis and treatment monitoring of CRC. The article discusses three major classes of biomarkers used in this method: circulating tumor DNA (ctDNA), circulating tumor cells (CTC), and exosomes. Particular attention is paid to their role in cancer detection and monitoring of treatment response.<b>Discussion:</b> The accuracy and invasiveness of liquid biopsy biomarkers are compared with traditional biopsy techniques. It is emphasized that liquid biopsies can provide real-time insight into tumor dynamics while minimizing patient discomfort. The clinical applications of these biomarkers are discussed, focusing on their utility in early disease detection, prognostication of tumor outcome, and development of personalized therapeutic strategies. Particular emphasis is placed on their transformative potential in improving treatment outcomes for patients with colorectal cancer.<b>Conclusions:</b> Liquid biopsies are a key element in the evolving landscape of oncology care. Their development and use have the potential to significantly improve patients' quality of life and the effectiveness of cancer treatment.

& lt; b>介绍:& lt; / b>结直肠癌(CRC)仍然是全球癌症相关发病率和死亡率的主要原因之一,因此需要不断寻找创新的诊断和疾病监测方法。传统技术虽然有效,但具有高度侵入性,可能给患者带来风险,这促使开发侵入性较小的替代方法。其中一种方法是液体活检,这是一种分析体液中循环生物标志物的技术。本文介绍液体活检在结直肠癌诊断和治疗监测中的应用。本文讨论了该方法中使用的三大类生物标志物:循环肿瘤DNA (ctDNA)、循环肿瘤细胞(CTC)和外泌体。特别关注它们在癌症检测和治疗反应监测中的作用。< >;对液体活检生物标志物的准确性和侵入性与传统活检技术进行了比较。强调液体活检可以提供实时洞察肿瘤动态,同时最大限度地减少患者的不适。本文讨论了这些生物标志物的临床应用,重点讨论了它们在早期疾病检测、肿瘤预后预测和个性化治疗策略开发方面的应用。特别强调的是它们在改善结直肠癌患者治疗结果方面的变革性潜力。液体活组织检查是肿瘤护理不断发展的关键因素。它们的开发和使用有可能显著改善患者的生活质量和癌症治疗的有效性。
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引用次数: 0
Surgical management options for control of presacral venous plexus hemorrhage - a review. 控制骶前静脉丛出血的外科治疗方案综述。
Pub Date : 2025-03-19 DOI: 10.5604/01.3001.0055.0530
Sajad Ahmad Salati, Mohammad Al Fehaid

<b>Introduction:</b> Presacral venous plexus (PSVP) is the lowest portion of the anterior external vertebral venous system, and injury to it with subsequent hemorrhage is a recognised and potentially lethal complication that may be encountered during pelvic surgical operations. Conventional hemostatic treatments may not be able to control this hemorrhage, and innovative techniques are required to address this issue.<b>Aim:</b> By examining the current techniques for managing PSVP hemorrhage, this study aims to remind the surgeons about possible management approaches that could effectively address this critical scenario.<b>Methods:</b> A systematic search of the PubMed database, Google Scholar, Web of Science, and ResearchGate was conducted to retrieve peer-reviewed scientific articles related to PSVP hemorrhage.<b>Conclusions:</b> There are several ways to establish hemostasis in these circumstances, and the patient's hemodynamic conditionand the exact location of the bleeder determine which approach is best. Therefore, it is imperative that surgeons' knowledge ofthese procedures be raised and that a variety of hemostatic medications be made available in operating rooms.

& lt; b>介绍:& lt; / b>骶前静脉丛(PSVP)是前椎体外静脉系统的最低部分,其损伤并随后出血是盆腔外科手术中可能遇到的潜在致命并发症。传统的止血治疗可能无法控制这种出血,需要创新的技术来解决这个问题。通过检查目前处理PSVP出血的技术,本研究旨在提醒外科医生可能的管理方法,可以有效地解决这一关键情况。方法:<;/b>;系统检索PubMed数据库、b谷歌Scholar、Web of Science和ResearchGate,检索与PSVP出血相关的同行评议的科学文章。在这种情况下,有几种止血方法,根据患者的血流动力学状况和出血点的确切位置决定哪一种方法最好。因此,外科医生必须;提高对这些程序的认识,并在手术室提供各种止血药物。
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引用次数: 0
Unveiling Observation Bias in Pilonidal Sinus Disease Studies: A Comparative Analysis of Study Designs and Follow-Up Protocols. 揭示毛细窦疾病研究中的观察偏倚:研究设计和随访方案的比较分析。
Pub Date : 2025-03-14 DOI: 10.5604/01.3001.0055.0465
Dietrich Doll, Susanne Haas, Ida Kaad Faurschou, Theo Hackmann, Myriam Braun-Muenker, Christina Oetzmann von Sochaczewski

<b>Introduction:</b> The extent of observation bias in long-term surgical outcomes due to inadequate or unplanned follow-up in pilonidal sinus disease (PSD) studies is unclear. We made a hypothesis on the high risk of underreported recurrence in studies relying on the patients returning in case of recurrent disease (return on recurrence; ROR).<b>Aim:</b> To investigate and quantify the amount of bias associated with regular <i>vs.</i> return-on-recurrence follow-up of patients.<b>Materials and methods:</b> A total of 5.485 retrievable PSD publications were screened for eligibility, yielding 1.222 PSD studies with 135.349 patients treated, published between 1833 and 2023, included for analysis. Of these, 139 were Randomized Controlled Trials (RCT), 54 were ROR trials, and 1,029 were non-RCT non-ROR (N) trials. Recurrence rates were compared between groups<b>Results:</b> The five-year recurrence rates across all treatments in PSD were 18.9% for RCTs, 10.4% for N trials, and 12.4% forROR trials. Recurrence rates in the N and the ROR trials were statistically indistinguishable at ten-year follow-up (p = 0.1),whereas RCTs show significantly higher recurrence rates than N or ROR at 10-year follow-ups (p<0.001, p<0.001). Comparingonly primary open treatment, the five-year recurrence rate was 18.6% for RCT trials, 11.5% for N trials, and 4.1% for ROR trials.The recurrence rates at 10-year follow-up in the ROR and N trials were 20.1% and 19.7%, respectively. Notably, there was nodata available for 10-year follow-up in RCTs.<b>Conclusions:</b> Observation bias seems to significantly impact the results of ROR studies. Implementing a well-structured, all-encompassing patient follow-up at specific time intervals can effectively mitigate this bias, which might otherwise compromise the validity of our findings.<b>Significance of work:</b> The extent of observation bias in ROR studies compared to RCTs and non-RCTs remains unknown. Ourscrutiny of excision and primary open therapy, the largest therapeutic cohort globally, reveals ROR recurrence rates potentiallydeflated by three to fourfold relative to RCTs or non-RCT findings.

& lt; b>介绍:& lt; / b>在毛鞘窦疾病(PSD)研究中,由于随访不充分或计划外,长期手术结果的观察偏倚程度尚不清楚。我们对依赖于复发性疾病患者复诊的研究中低报复发的高风险进行了假设(复发复诊;ROR)。你们;b>目的:& lt; / b>调查和量化与常规<;i>vs.</i>;患者复发后随访。材料与方法:<;/b>;共筛选了5.485篇可检索的PSD出版物,纳入了1833年至2023年间发表的1.222篇PSD研究,共治疗了135.349例患者。其中,139项为随机对照试验(RCT), 54项为ROR试验,1029项为非RCT非ROR (N)试验。比较两组患者复发率<;b>;结果<;/b>;所有PSD治疗的5年复发率在随机对照试验中为18.9%,N试验为10.4%,ror试验为12.4%。N组和ROR组的复发率在10年随访时无统计学差异(p = 0.1),而rct组在10年随访时的复发率明显高于N组或ROR组(p < 0.001, p < 0.001)。与初次开放治疗相比,RCT试验的5年复发率为18.6%,N试验为11.5%,ROR试验为4.1%。10年随访时,ROR试验和N试验的复发率分别为20.1%和19.7%。值得注意的是,在随机对照试验中没有10年随访的数据。观察偏倚似乎会显著影响ROR研究的结果。在特定的时间间隔内实施结构良好、全面的患者随访可以有效地减轻这种偏差,否则这种偏差可能会损害我们研究结果的有效性。与rct和非rct相比,ROR研究的观察偏倚程度尚不清楚。我们对全球最大的治疗队列——切除和首次开放治疗的研究显示,相对于随机对照试验或非随机对照试验结果,ROR复发率可能降低了三到四倍。
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引用次数: 0
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Polski przeglad chirurgiczny
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