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Efficacy of joint denervation for degenerative disease of the joints in the hand: a review. 关节去神经治疗手部关节退行性疾病的疗效:综述。
Pub Date : 2024-07-09 DOI: 10.5604/01.3001.0054.6749
Andrzej Żyluk, Tomasz Mazurek, Bernard Piotuch

Osteoarthritis of the fingers and wrist, whether primary or secondary, is the most common degenerative disease. Its incidence is increasing due to the aging of the population. Most of the patients can be treated conservatively with good effect, but when conservative treatment fails, surgical intervention is considered. Essentially, there are 2 types of operations for this disease - radical (bone excision, arthrodesis, arthroplasty with an implant), and non-radical (joint denervation). Denervation of the joints has obvious advantages such as non-compromising the joint anatomy, preservation of range of motion, avoiding of an implant and low rate of complications. Denervation can be offered to younger patients, whatever their functional demands. Preservation of the bony anatomy does not preclude any further, more radical surgical interventions. This article presents a comprehensive information about methods of denervation of particular joints within the hand and their effectiveness in osteoarthritis. The current literature provides convincing evidence that denervation is a reliable and reproducible surgical technique for painful osteoarthritic conditions of the hand. It should be considered in patients presenting with painful joints which are still mobile, regardless the initial aetiology.

无论是原发性还是继发性,手指和手腕骨关节炎都是最常见的退行性疾病。随着人口老龄化的加剧,其发病率也在不断上升。大多数患者可以通过保守治疗获得良好效果,但当保守治疗无效时,就需要考虑手术治疗。从根本上说,治疗这种疾病的手术有两种--根治性手术(骨切除术、关节切除术、植入假体的关节成形术)和非根治性手术(关节去神经化)。关节去神经化具有明显的优势,如不破坏关节解剖结构、保留关节活动范围、避免植入假体以及并发症发生率低。无论患者的功能需求如何,都可以为年轻患者提供去神经支配治疗。保留骨骼解剖结构并不排除进一步采取更激进的手术干预措施。本文全面介绍了手部特定关节的去神经化方法及其对骨关节炎的疗效。目前的文献提供了令人信服的证据,证明去神经支配是治疗手部骨关节炎疼痛的一种可靠且可重复的外科技术。无论最初的病因是什么,关节疼痛但仍可活动的患者都应考虑使用该技术。
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引用次数: 0
The correlation of BMI and insulin resistance in moderately burned patients. 中度烧伤患者BMI与胰岛素抵抗的相关性研究。
Pub Date : 2024-07-09 DOI: 10.5604/01.3001.0054.6748
Agnieszka Surowiecka, Tomasz Korzeniowski, Patrycja Korulczyk, Julia Budzyńska, Magdalena Leśniewska, Ilona Kozioł, Zofia Górecka, Maciej Łączyk, Grzegorz Wilhelm, Małgorzata Staśkiewicz, Kamil Torres, Jerzy Strużyna

<b>Introduction:</b> Obesity is strongly related to serious comorbidities that might affect the healing process. Elevated Body Mass Index (BMI) and insulin resistance have a significant impact on the development of the metabolic syndrome often leading to lethal cardiovascular complications.<b>Aim:</b> The aim of the study was to verify the correlation of BMI and insulin resistance with clinical parameters of moderately burned patients.<b>Materials and methods:</b> There were 149 patients enrolled in the study and their clinical data was retrospectively analyzed. The laboratory tests, insulin demand, BMI, and surgical procedures were evaluated on admission and discharge.<b>Results:</b> Burned patients who required insulin were characterized by worse laboratory results on admission to the burn unit, they had lower hemoglobin (HGB) levels (P = 0.0001), higher creatinine levels by 0.323 units (P = 0.009), higher C-reactive protein (CRP) by approximately 94 units (P = 0.0001), as higher procalcitonin (PCT) by approximately 0.5 units (P = 0.001) as compared to non-insulin-treated patients. Moreover, burned patients who required insulin stayed in the hospital for an average of 10 days longer. All patients from the insulin-demand subgroup had elevated triglycerides (Tg) levels on admission with increased indexes of insulin resistance.<b>Discussion:</b> Our study suggests that the protective effect of a higher BMI in burned patients, known as the 'obesity paradox' may be compromised by insulin resistance.<b>Conclusions and significance of the study:</b> The results show that elevated Tg on admission to the burn unit coexisting with a BMI over 25 kg/m<sup>2</sup> may be used as an important prognostic factor and may help with prediction of insulin demand and worse outcome in moderately burned patients.

& lt; b>介绍:& lt; / b>肥胖与可能影响愈合过程的严重合并症密切相关。身体质量指数(BMI)升高和胰岛素抵抗对代谢综合征的发展有重要影响,代谢综合征常导致致命的心血管并发症。本研究的目的是验证中度烧伤患者的BMI和胰岛素抵抗与临床参数的相关性。材料和方法:<;/b>;共有149名患者参加了这项研究,并对他们的临床资料进行了回顾性分析。在入院和出院时评估实验室检查、胰岛素需求、BMI和手术程序。结果:<;/b>;需要胰岛素治疗的烧伤患者入院时的实验室结果较差,与未接受胰岛素治疗的患者相比,他们的血红蛋白(HGB)水平较低(P = 0.0001),肌酐水平较高0.323单位(P = 0.009), c反应蛋白(CRP)升高约94单位(P = 0.0001),降钙素原(PCT)升高约0.5单位(P = 0.001)。此外,需要胰岛素治疗的烧伤患者在医院的平均住院时间延长了10天。所有胰岛素需求亚组患者入院时甘油三酯(Tg)水平均升高,胰岛素抵抗指标增加。我们的研究表明,较高的BMI对烧伤患者的保护作用,即所谓的“肥胖悖论”,可能会被胰岛素抵抗所削弱。结果表明,入院时Tg升高与BMI超过25kg / mg / kg并存。可作为一个重要的预后因素,并可帮助预测中度烧伤患者的胰岛素需求和更糟糕的结局。
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引用次数: 0
The influence of supportive therapy with a six-component myophlebotropic preparation on the reduction of symptoms in patients with symptoms of hemorrhoidal disease. 使用六成分肌注制剂进行辅助治疗对减轻痔疮患者症状的影响。
Pub Date : 2024-06-24 DOI: 10.5604/01.3001.0054.6443
Anna Kwiatkowska, Maciej Borejsza-Wysocki, Michał Głyda, Anna Maria Pietrzak, Marek Szczepkowski, Andrzej Organ, Tomasz Banasiewicz

<b>Introduction:</b> Hemorrhoidal disease is the most common disease treated in proctology ambulatories. Conservative treatment is the basic form of treatment for this disease. One of the elements of treatment may be preparations with myoand phlebotropic effects.<b>Aim:</b> To assess the effect of a multi-ingredient myophlebotropic dietary supplement used as an adjunct on the rate and effectiveness of symptom relief in patients with stage II and III hemorrhoidal disease.<b>Material and method:</b> Patients with stage II and III hemorrhoidal disease with clinical symptoms such as pain, burning, itching and bleeding were qualified for the study. The patients were divided into two groups. The control group (Group I) of 29 patients receiving standard local treatment plus placebo and the study group (Group II) of 32 patients receiving the same local treatment and a six-component myophlebotropic product. Symptoms were analyzed at the time of inclusion in the study (day 0), after 4 and 10 days of therapy. The severity of hemorrhoidal disease and the feeling of relief were assessed on the day of inclusion (W0) and after 30 days of therapy.<b>Results:</b> There were no statistical differences between the groups in terms of disease advancement, age, gender, and duration of symptoms. Compared to the moment of inclusion in the study (W0), after 4 days (W1), after 10 days (W2) of taking the multi- -component product, there was a statistically significant improvement in the VAS scale: spontaneous pain and pain during defecation. In the qualitative assessment (yes/no), there were statistically significantly fewer cases of burning in the anus and itching. The treatment did not affect the rate of spontaneous bleeding, which was low at the beginning of the study, but significantly reduced the rate of bleeding during defecation. After 30 days of observation, it was found that the improvement in the severity of hemorrhoidal disease symptoms was significantly higher in the group using the tested preparation. Relief after a month of the study (one-question method) was noted in the group of patients receiving the tested product.<b>Conclusions:</b> The tested six-component myophlebotropic product proved to be effective in reducing the severity of symptoms such as spontaneous pain, pain during defecation, burning/burning in the anus and bleeding during defecation. Statistical significance was demonstrated in the symptom's relief and reduction in the severity of hemorrhoidal disease.

<b>引言:</b> 痔疮是肛肠科最常见的疾病。保守治疗是治疗这种疾病的基本方法。</b>目的:</b>评估作为辅助治疗的多成分肌注膳食补充剂对 II 期和 III 期痔疮患者症状缓解率和有效性的影响。<b>材料和方法:</b> 符合研究条件的Ⅱ期和Ⅲ期痔疮患者,临床症状为疼痛、灼热、瘙痒和出血。患者分为两组。对照组(I 组)29 名患者接受标准的局部治疗和安慰剂,研究组(II 组)32 名患者接受相同的局部治疗和六组分肌注产品。对纳入研究时(第 0 天)、治疗 4 天和 10 天后的症状进行了分析。在加入研究的当天(W0)和治疗 30 天后,对痔疮的严重程度和缓解感觉进行了评估。与加入研究时(W0)、服用多组分产品 4 天后(W1)和 10 天后(W2)相比,VAS 量表中的自发疼痛和排便时疼痛均有显著改善。在定性评估(是/否)中,肛门烧灼感和瘙痒的病例明显减少。自发性出血率在研究开始时很低,但治疗并未影响自发性出血率,但排便时的出血率明显降低。经过 30 天的观察发现,使用试验制剂的小组痔疮症状严重程度的改善程度明显更高。结论:</b> 经测试的六组分肌注产品可有效减轻自发疼痛、排便疼痛、肛门灼热/烧灼感和排便出血等症状的严重程度。在缓解症状和减轻痔疮严重程度方面具有统计学意义。
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引用次数: 0
Analysis of quality of life in patients with clinically severe obesity and type 2 diabetes mellitus after laparoscopic sleeve gastrectomy - a 12-month prospective observational study. 临床重度肥胖合并2型糖尿病患者腹腔镜袖胃切除术后的生活质量分析——一项为期12个月的前瞻性观察研究
Pub Date : 2024-05-09 DOI: 10.5604/01.3001.0054.5125
Michał Wysocki, Magdalena Mizera, Izabela Karpińska, Kuba Ptaszkiewicz, Piotr Małczak, Magdalena Pisarska-Adamczyk, Michał Kania, Piotr Major

<b>Introduction:</b> Due to a short history of laparoscopic sleeve gastrectomy (LSG) as an independent bariatric procedure, we stilllack studies providing analysis of the quality of life (QoL) in patients with type 2 diabetes mellitus (DM2).<b>Aim:</b> We aimed to assess the influence of LSG on QoL in obese patients with DM2.<b>Material and Methods:</b> Prospective, observational study included patients with: morbid obesity, body mass index (BMI) ≥ 35 kg/m and ≤ 50 kg/m<sup>2</sup>, DM2 shorter than 10 years, qualified for LSG. Bariatric Analysis and Reporting Outcome System (BAROS) that included the Moorehead-Ardelt Quality of Life Questionnaire II (MA-QoLQII) score, and the SF-36 Health Survey (SF-36) questionnaire were used for repetitive assessment of QoL before LSG and after one and 12 months following surgery. Selected clinical and biochemical parameters were also repeatedly measured.<b>Results:</b> Thirty-three patients were included in the study (23 females). Patients' mean age was 45 10 years. BAROS significantly increased before LSG, one month, and one year after surgery (0.63 1.12, 2.94 1.90, and 4.97 2.08, respectively). The MA-QoLQII score significantly rose with an increase of excess body mass index loss (EBMIL) (P = 0.002) and remission of DM2 (P = 0.049), while inversely correlated with Homeostatic Model Assessment for Insulin Resistance index (HOMA-IR) (P = 0.003). Degenerative joint disease (P = 0.025) and average time of low glucose concentration in continuous glucose monitoring (CGM) (P = 0.005) had an inverse correlation with SF-36 Physical Component Summaries (PCS), standardized for cardiovascular comorbidity, EBMIL and HOMA-IR (P = 0.839; P = 0.086; P = 0.571, respectively). EBMIL (P = 0.003), remission of DM2 (P < 0.001) had a positive correlation with Mental Component Summaries (MCS), while HOMA-IR (P < 0.001) and count of low glucose concentration events (P = 0.022) had an inverse correlation with MCS, while standardized for average glucose concentration in CGM after 12 months (P = 0.586).<b>Discussion:</b> Significant improvement in QoL was observed in patients with DM2 after LSG. Remission of DM2, higher EBMIL, lower HOMA-IR, fewer and shorter low glucose concentration events in CGM after 12 months were factors that increased selected QoL scores.

& lt; b>介绍:& lt; / b>由于腹腔镜袖胃切除术(LSG)作为一种独立的减肥手术的历史较短,我们仍然缺乏对2型糖尿病(DM2)患者的生活质量(QoL)进行分析的研究。我们旨在评估LSG对肥胖DM2患者生活质量的影响。材料与方法:<;/ >;前瞻性观察性研究纳入了病态肥胖、体重指数(BMI)≥35 kg/m和≤50 kg/m、体重指数(BMI)≥2 kg/m、DM2≤10年、符合LSG条件的患者。体重分析和报告结果系统(BAROS)包括Moorehead-Ardelt生活质量问卷II (ma - qolqi)评分和SF-36健康调查问卷(SF-36),用于LSG前和手术后1个月和12个月的生活质量重复评估。同时反复测定选定的临床及生化参数。结果:<;/ >;研究纳入33例患者(女性23例)。患者平均年龄45 - 10岁。BAROS在LSG术前、术后1个月、1年显著升高(分别为0.63 1.12、2.94 1.90、4.97 2.08)。ma - qolqi评分随过量体重指数损失(bmil)增加(P = 0.002)和DM2缓解(P = 0.049)而显著升高,与胰岛素抵抗指数(HOMA-IR)稳态模型评估(P = 0.003)呈负相关(P = 0.003)。退行性关节疾病(P = 0.025)和连续血糖监测(CGM)中低糖浓度的平均时间(P = 0.005)与SF-36物理成分摘要(PCS)、心血管共病标准化、ebil和HOMA-IR (P = 0.839;P = 0.086;P = 0.571)。EBMIL (P = 0.003)、DM2缓解(P <;0.001)与心理成分总结(MCS)呈正相关,而HOMA-IR (P <;0.001)和低血糖事件计数(P = 0.022)与MCS呈负相关,而标准化的12个月后CGM的平均葡萄糖浓度(P = 0.586)。LSG后DM2患者的生活质量明显改善。12个月后,DM2的缓解、EBMIL的升高、HOMA-IR的降低、CGM低糖浓度事件的减少和时间的缩短是提高选择的生活质量评分的因素。
{"title":"Analysis of quality of life in patients with clinically severe obesity and type 2 diabetes mellitus after laparoscopic sleeve gastrectomy - a 12-month prospective observational study.","authors":"Michał Wysocki, Magdalena Mizera, Izabela Karpińska, Kuba Ptaszkiewicz, Piotr Małczak, Magdalena Pisarska-Adamczyk, Michał Kania, Piotr Major","doi":"10.5604/01.3001.0054.5125","DOIUrl":"10.5604/01.3001.0054.5125","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Due to a short history of laparoscopic sleeve gastrectomy (LSG) as an independent bariatric procedure, we stilllack studies providing analysis of the quality of life (QoL) in patients with type 2 diabetes mellitus (DM2).&lt;b&gt;Aim:&lt;/b&gt; We aimed to assess the influence of LSG on QoL in obese patients with DM2.&lt;b&gt;Material and Methods:&lt;/b&gt; Prospective, observational study included patients with: morbid obesity, body mass index (BMI) ≥ 35 kg/m and ≤ 50 kg/m&lt;sup&gt;2&lt;/sup&gt;, DM2 shorter than 10 years, qualified for LSG. Bariatric Analysis and Reporting Outcome System (BAROS) that included the Moorehead-Ardelt Quality of Life Questionnaire II (MA-QoLQII) score, and the SF-36 Health Survey (SF-36) questionnaire were used for repetitive assessment of QoL before LSG and after one and 12 months following surgery. Selected clinical and biochemical parameters were also repeatedly measured.&lt;b&gt;Results:&lt;/b&gt; Thirty-three patients were included in the study (23 females). Patients' mean age was 45 10 years. BAROS significantly increased before LSG, one month, and one year after surgery (0.63 1.12, 2.94 1.90, and 4.97 2.08, respectively). The MA-QoLQII score significantly rose with an increase of excess body mass index loss (EBMIL) (P = 0.002) and remission of DM2 (P = 0.049), while inversely correlated with Homeostatic Model Assessment for Insulin Resistance index (HOMA-IR) (P = 0.003). Degenerative joint disease (P = 0.025) and average time of low glucose concentration in continuous glucose monitoring (CGM) (P = 0.005) had an inverse correlation with SF-36 Physical Component Summaries (PCS), standardized for cardiovascular comorbidity, EBMIL and HOMA-IR (P = 0.839; P = 0.086; P = 0.571, respectively). EBMIL (P = 0.003), remission of DM2 (P &lt; 0.001) had a positive correlation with Mental Component Summaries (MCS), while HOMA-IR (P &lt; 0.001) and count of low glucose concentration events (P = 0.022) had an inverse correlation with MCS, while standardized for average glucose concentration in CGM after 12 months (P = 0.586).&lt;b&gt;Discussion:&lt;/b&gt; Significant improvement in QoL was observed in patients with DM2 after LSG. Remission of DM2, higher EBMIL, lower HOMA-IR, fewer and shorter low glucose concentration events in CGM after 12 months were factors that increased selected QoL scores.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"96 6","pages":"20-30"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health, and Eating Disorders in Patients After Roux-en-Y Gastric Bypass Surgery (RYGB). 胃旁路手术 (RYGB) 术后患者的心理健康和饮食失调。
Pub Date : 2024-05-09 DOI: 10.5604/01.3001.0054.5209
Aleksandra Iljin, Michał Wlaźlak, Aneta Sitek, Bogusław Antoszewski, Tomasz Zieliński, Agnieszka Gmitrowicz, Paweł Kropiwnicki, Janusz Strzelczyk

<b>Introduction:</b> Obesity, as one of the main health problems worldwide, is associated with an increased risk of developing mental and eating disorders and negative eating habits. Bariatric surgery allows for rapid weight loss and alleviates the symptoms of concomitant diseases in obese patients.<b>Aim:</b> Pre- and postoperative estimation of mental disorders and eating behaviors in patients after Roux-en-Y Gastric Bypass (RYGB).<b>Material and methods:</b> Analysis of data from up to 5 years of follow-up including clinical examination and questionnaires.<b>Results:</b> Following parameters decreased after RYGB: anxiety and hyperactivity from 32.81% to 21.88%, mood disorders - 31.25% to 20.31%, substance abuse - 40.63% to 28.13%, emotional eating - 76.56% to 29.69%, binge eating - 50% to 6.25%, night eating - 87.5% to 20.31%. Postoperative rates of: negative eating habits, daily intake of calories and sweetened beverages, flatulence, constipation, and abdominal pain decreased, while the rate of food intolerance and emesis increased.<b>Conclusions:</b> In our patients, the occurrence of: mental and eating disorders, negative eating habits, daily calories, sweetened beverages, coffee intake decreased after weight loss (as a result of RYGB), but water, vegetables and fruit consumption increased. Lower rate of flatulence, constipation, and abdominal pain, but higher of food intolerance and emesis were also confirmed after RYGB.

<b>引言:</b>肥胖症是全球主要健康问题之一,与精神和饮食失调以及不良饮食习惯的发病风险增加有关。减肥手术可以快速减轻肥胖患者的体重,并缓解伴随疾病的症状。</b>目的:</b>术前和术后对Roux-en-Y胃旁路术(RYGB)患者的精神障碍和饮食行为进行评估。</b>结果:</b>RYGB 术后以下指标有所下降:焦虑和多动从 32.81% 降至 21.88%,情绪障碍 - 31.25% 降至 20.31%,药物滥用 - 40.63% 降至 28.13%,情绪化饮食 - 76.56% 降至 29.69%,暴饮暴食 - 50% 降至 6.25%,夜食 - 87.5% 降至 20.31%。术后不良饮食习惯、每日摄入热量和甜饮料、胀气、便秘和腹痛的发生率下降,而食物不耐受和呕吐的发生率上升。胀气、便秘和腹痛的发生率较低,但食物不耐受和呕吐的发生率较高。
{"title":"Mental Health, and Eating Disorders in Patients After Roux-en-Y Gastric Bypass Surgery (RYGB).","authors":"Aleksandra Iljin, Michał Wlaźlak, Aneta Sitek, Bogusław Antoszewski, Tomasz Zieliński, Agnieszka Gmitrowicz, Paweł Kropiwnicki, Janusz Strzelczyk","doi":"10.5604/01.3001.0054.5209","DOIUrl":"https://doi.org/10.5604/01.3001.0054.5209","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Obesity, as one of the main health problems worldwide, is associated with an increased risk of developing mental and eating disorders and negative eating habits. Bariatric surgery allows for rapid weight loss and alleviates the symptoms of concomitant diseases in obese patients.&lt;b&gt;Aim:&lt;/b&gt; Pre- and postoperative estimation of mental disorders and eating behaviors in patients after Roux-en-Y Gastric Bypass (RYGB).&lt;b&gt;Material and methods:&lt;/b&gt; Analysis of data from up to 5 years of follow-up including clinical examination and questionnaires.&lt;b&gt;Results:&lt;/b&gt; Following parameters decreased after RYGB: anxiety and hyperactivity from 32.81% to 21.88%, mood disorders - 31.25% to 20.31%, substance abuse - 40.63% to 28.13%, emotional eating - 76.56% to 29.69%, binge eating - 50% to 6.25%, night eating - 87.5% to 20.31%. Postoperative rates of: negative eating habits, daily intake of calories and sweetened beverages, flatulence, constipation, and abdominal pain decreased, while the rate of food intolerance and emesis increased.&lt;b&gt;Conclusions:&lt;/b&gt; In our patients, the occurrence of: mental and eating disorders, negative eating habits, daily calories, sweetened beverages, coffee intake decreased after weight loss (as a result of RYGB), but water, vegetables and fruit consumption increased. Lower rate of flatulence, constipation, and abdominal pain, but higher of food intolerance and emesis were also confirmed after RYGB.</p>","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"96 3","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and effectiveness of consecutive 191 endoscopic ultrasonography-guided biliary drainage procedures: a single-center experience. 连续191例超声内镜引导胆道引流术的安全性和有效性:单中心经验。
Pub Date : 2024-05-09 DOI: 10.5604/01.3001.0054.5126
Michał Zieliński, Mateusz Jagielski, Jacek Piątkowski, Marek Jackowski

<b>Introduction:</b> The development of endoscopic ultrasonography (EUS) has enabled extra-anatomical transmural access to the bile ducts, thus making it possible to perform endoscopic biliary anastomoses with the gastrointestinal (GI) tract and obtain extra-anatomical transpapillary access. EUS provides an alternative to the existing methods of biliary drainage (BD) for cases in which endoscopic retrograde cholangiopancreatography (ERCP) is ineffective.<b>Aim:</b> This study aimed to evaluate the efficacy and safety of extraanatomical endoscopic biliary access methods for the treatment of benign and malignant biliary strictures.<b>Material and methods:</b> This retrospective analysis included treatment results of all patients with obstructive jaundice and biliary strictures who were treated endoscopically in our department between 2016 and 2023. The study group comprised patients in whom EUS-guided transmural access was used during ERCP because of biliary strictures and the lack of transpapillary access.<b>Results:</b> Twenty-eight patients (14.66%) underwent endoscopic transpapillary biliary stenting via a transmural approach under EUS guidance. The remaining 163 patients (85.34%) underwent extraanatomical transmural biliodigestive anastomosis. Technical success was achieved in 186 of 191 (97.38%) patients. Clinical success was achieved in 170 of 191 (89.01%) patients. Complications were reported for 32 of 191 (16.75%) patients, including fatal complications for 6 of 191 (3.14%) patients.<b>Conclusions:</b> Advanced endoscopic techniques involving EUS-guided transmural access are effective and safe for biliary strictures. They provide an alternative to other drainage techniques when ERCP is ineffective and improve the quality of life of patients undergoing palliative treatment for biliary strictures with unresectable cancer of the biliopancreatic area.

& lt; b>介绍:& lt; / b>超声内镜(EUS)的发展使经解剖外的胆管经壁通路成为可能,从而使胆管经内镜与胃肠道吻合,获得经解剖外的经毛细血管通路成为可能。对于内镜逆行胆管造影(ERCP)无效的病例,EUS提供了一种替代现有胆道引流(BD)方法的方法。本研究旨在评价经解剖外胆道内镜入路治疗胆道良恶性狭窄的疗效和安全性。材料和方法:<;/ & >;回顾性分析2016年至2023年在我科内镜下治疗的梗阻性黄疸合并胆道狭窄患者的治疗结果。研究组包括由于胆道狭窄和缺乏经毛细血管通路而在ERCP中使用eus引导下的经壁通路的患者。28例(14.66%)患者在EUS指导下经经壁入路行内镜下经毛细血管胆道支架植入术。其余163例(85.34%)行解剖外经壁胆消化吻合术。191例患者中186例(97.38%)技术成功。191例患者中有170例(89.01%)获得临床成功。191例患者中出现并发症32例(16.75%),其中致死性并发症6例(3.14%)。先进的内镜技术包括eus引导下的跨壁通道,对胆道狭窄是有效和安全的。当ERCP无效时,它们为其他引流技术提供了另一种选择,并改善了胆道狭窄伴不可切除胆管胰区癌症患者接受姑息治疗的生活质量。
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引用次数: 0
Current approach to the management of preoperative iron deficiency anemia in colorectal cancer patients: a review of literature. 当前处理结直肠癌患者术前缺铁性贫血的方法:文献综述。
Pub Date : 2024-05-09 DOI: 10.5604/01.3001.0054.5124
Jakub Rudzki, Mikołaj Polewka, Paulina Agopsowicz, Anna Nowak, Michał Porada, Piotr F Czempik

<b>Introduction:</b> The prevalence of preoperative anemia is the highest in the group of colorectal cancer (CRC) patients and may reach over 75%. The prevalence of anemia in CRC patients increases even further following surgery. Approximately 75-80% of anemic CRC patients present with absolute or functional iron deficiency (ID). Preoperative anemia constitutes an independent risk factor for allogeneic blood transfusion (ABT), postoperative complications, prolonged length of hospital stay, and increased mortality. ABT is itself associated with increased morbidity and mortality.<b>Aim:</b> The aim of this review article was to present the pathophysiology and the current approach to the diagnostics and treatment of preoperative iron deficiency anemia (IDA) in CRC patients.<b>Material and methods:</b> Extensive search of medical literature databases was performed (Pubmed, Embase). The key words that were used were as follows: CRC, colorectal surgery, ID, IDA, intravenous iron, Patient Blood Management (PBM).<b>Results:</b> There are several laboratory parameters that can be used for IDA diagnosis, however, the simplest and most cost- -effective is reticulocyte hemoglobin equivalent (RET-He). Pathophysiologic features of IDA in CRC patients favor treatment with intravenous, as opposed to oral, iron formulations. Applying PBM strategies minimizes the exposure to ABT.<b>Conclusions:</b> Preoperative IDA is highly prevalent among CRC patients. Preoperative anemia is an independent risk factor for ABT, increased morbidity and mortality, as well as prolonged hospital length of stay. The same negative consequences are associated with ABT. Therefore, preoperative IDA in CRC patients needs to be screened for, diagnosed, and treated before surgery. Effective treatment of preoperative IDA in CRC patients is with intravenous iron formulations. ABT should be the treatment of last resort due to the risk of negative clinical consequences, including an increased rate of cancer recurrence.

<b>引言:</b>术前贫血在结直肠癌(CRC)患者中发病率最高,可达 75% 以上。手术后,CRC 患者的贫血患病率会进一步上升。约 75-80% 的贫血 CRC 患者表现为绝对或功能性缺铁(ID)。术前贫血是异体输血(ABT)、术后并发症、住院时间延长和死亡率增加的独立风险因素。<b>目的:</b>这篇综述文章的目的是介绍 CRC 患者术前缺铁性贫血 (IDA) 的病理生理学以及目前的诊断和治疗方法。使用的关键词如下:<b>结果:</b>有多种实验室参数可用于 IDA 诊断,但最简单、最经济有效的是网织红细胞血红蛋白当量(RET-He)。CRC 患者 IDA 的病理生理学特征有利于使用静脉注射而非口服铁制剂进行治疗。应用 PBM 策略可最大限度地减少 ABT 的暴露。术前贫血是导致 ABT、发病率和死亡率增加以及住院时间延长的独立风险因素。同样的负面影响也与 ABT 有关。因此,需要在手术前筛查、诊断和治疗 CRC 患者的术前 IDA。CRC 患者术前 IDA 的有效治疗方法是静脉注射铁制剂。由于 ABT 有可能导致负面临床后果,包括增加癌症复发率,因此 ABT 应作为最后的治疗手段。
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引用次数: 0
Applicability of sodium butyrate preparations from a surgeon's and gastroenterologist's perspective. 从外科医生和胃肠病学家的角度看丁酸钠制剂的适用性。
Pub Date : 2024-04-30 DOI: 10.5604/01.3001.0054.4152
Anna Pietrzak, Tomasz Banasiewicz

In recent years, much has been written about the possibilities of using exogenous sodium butyrate in the prevention and treatment of gastrointestinal diseases, in prehabilitation, in peri- and postoperative treatment, as well as its local application. It became possible thanks to the development of a special formulation (microencapsulation technique) enabling the delivery of unstable butyrate compounds to the large intestine, where it is used primarily as a source of energy. It also plays a key role in maintaining body homeostasis by maintaining the integrity of the intestinal epithelium and stimulating the intestinal immune system. There is growing evidence of the effectiveness of sodium butyrate in various areas of health. The following article discusses the possibilities of using microencapsulated sodium butyrate in the prevention and treatment of gastrointestinal diseases from the perspective of a gastroenterologist and gastrointestinal surgeon.

近年来,关于外源性丁酸钠在胃肠道疾病的预防和治疗、术前康复、围手术期和术后治疗以及局部应用方面的可能性,已有很多论述。由于开发了一种特殊配方(微胶囊技术),可以将不稳定的丁酸钠化合物输送到大肠,而丁酸钠在大肠中主要用作能量来源。它还通过保持肠道上皮细胞的完整性和刺激肠道免疫系统,在维持体内平衡方面发挥着关键作用。越来越多的证据表明,丁酸钠在健康的各个领域都很有效。下面这篇文章将从肠胃病学家和肠胃外科医生的角度,讨论使用微胶囊丁酸钠预防和治疗肠胃疾病的可能性。
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引用次数: 0
The Impact of Botulinum Toxin A Application on Reducing the Necessity for "Component Separation Techniques" in Giant Incisional Hernias: A Dual-Center, Polish-Ukrainian, Retrospective Cohort Study. 肉毒毒素A应用对减少巨大切口疝“成分分离技术”必要性的影响:一项双中心、波兰-乌克兰回顾性队列研究。
Pub Date : 2024-04-24 DOI: 10.5604/01.3001.0054.4919
Mateusz Zamkowski, Orest Lerchuk, Andriy Porytsky, Zhanna Ushnevych, Volodymyr Khomyak, Maciej Śmietański

<b>Introduction:</b> Incisional hernias are prevalent complications, with significant recurrence rates and associated surgical wound complications. Giant hernias, classified by the European Hernia Society (EHS) as exceeding 10 cm (width dimension), pose a challenge due to the "loss of domain" effect. Component separation techniques (CST), including anterior component separation (ACS) and transversus abdominis release (TAR), are established interventions but have drawbacks related to the irreversible alteration of abdominal wall anatomy and associated risks. An alternative approach involves the preoperative application of Botulinum Toxin A (BTA) to reduce lateral abdominal muscle tension, facilitating hernial defect closure.<b>Aim:</b> The aim was to assess the impact of BTA on reducing the necessity for CST, the occurrence of surgical site complications,and the need for further interventions.<b>Materials and methods:</b> A retrospective cohort study was conducted across two reference centers specializing in hernia treatment in Poland and Ukraine. The study compared outcomes between patients undergoing elective abdominal wall reconstruction surgery for giant hernias, specifically looking at the requirement for CST following preoperative BTA application. Patients were divided into two groups - those who received BTA injections 3-4 weeks prior to surgery (BOTOX group) and those who did not (NON-BOTOX group).<b>Results:</b> The study found that in the BOTOX group, a significantly lower proportion of patients required CST compared to the NON-BOTOX group (46 <i>vs</i> 84%, P-value = 0.000124). Additionally, the BOTOX group experienced fewer postoperative complications, suggesting a beneficial effect of BTA in simplifying surgical procedures and enhancing patient outcomes.<b>Conclusions:</b> The findings support the use of preoperative BTA injections as a valuable adjunct in the management of giant abdominal hernias. This approach not only facilitates fascial closure without the need for extensive CST but also potentially reduces perioperative trauma and postoperative complications. Preoperative BTA injections significantly reduce the need for CST in giant incisional abdominal hernia repairs, offering a less invasive and more effective approach to fascial closure. The most important role of BTA is "downstaging" the hernia before surgery. This study highlights the importance of considering BTA injections in preoperative protocols, advocating for broader acceptance and reimbursement to improve surgical outcomes and patient care in hernia surgery.

& lt; b>介绍:& lt; / b>切口疝是常见的并发症,具有显著的复发率和相关的手术伤口并发症。欧洲疝气学会(EHS)将超过10厘米(宽度尺寸)的巨型疝气归类为“失域”效应,这是一个挑战。组件分离技术(CST),包括前组件分离(ACS)和腹侧释放(TAR),是公认的干预措施,但存在与腹壁解剖结构不可逆转的改变和相关风险相关的缺点。另一种方法是术前应用肉毒毒素A (BTA)来减少侧腹肌张力,促进疝缺损闭合。目的是评估BTA在减少CST必要性、手术部位并发症的发生以及进一步干预的必要性方面的影响。材料和方法:<;/ >;一项回顾性队列研究在波兰和乌克兰的两个专门研究疝气治疗的参考中心进行。该研究比较了接受选择性腹壁重建手术治疗巨大疝的患者的结果,特别关注了术前应用BTA后CST的要求。患者分为两组,术前3-4周接受BTA注射的患者(肉毒杆菌组)和未接受BTA注射的患者(非肉毒杆菌组)。研究发现,与未注射肉毒杆菌组相比,注射肉毒杆菌组需要CST的患者比例明显较低(46 <i>vs</i>;84%, p值= 0.000124)。此外,BOTOX组术后并发症较少,表明BTA在简化手术程序和提高患者预后方面具有有益作用。研究结果支持术前注射BTA作为治疗巨大腹疝的一种有价值的辅助手段。该入路不仅可以在不需要广泛CST的情况下促进筋膜闭合,而且还可以潜在地减少围手术期创伤和术后并发症。术前注射BTA可显著减少巨大切口腹疝修补术中CST的需要,为筋膜闭合提供了一种侵入性更小、更有效的方法。BTA最重要的作用是“降级”。手术前的疝。本研究强调了在术前方案中考虑BTA注射的重要性,提倡更广泛的接受和报销,以改善疝手术的手术效果和患者护理。
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引用次数: 0
Direct peroral cholangioscopy with laser lithotripsy in treating choledocholithiasis - single-institution experience. 直接经口胆道镜联合激光碎石治疗胆总管结石-单院经验。
Pub Date : 2024-04-12 DOI: 10.5604/01.3001.0054.4731
Konrad Kosztowny, Tomasz Klimczak, Tomasz Kraj, Karina Bieguszewska, Janusz Strzelczyk

<b>Introduction:</b> Choledocholithiasis (CCL) is one of the most common serious health consequences of cholelithiasis. For years, evacuation of stones using endoscopic retrograde cholangiopancreatography (ERCP) has been the first-line treatment. In 10-15% of cases, gallstones cannot be removed using the above-mentioned method and auxiliary methods are necessary; these are so-called difficult gallstones. Surgical treatment is sometimes necessary. The European Society of Gastrointestinal Endoscopy (ESGE) has recommended the use of cholangioscopy, including direct peroral cholangioscopy (DPOC), as one of the main treatment methods since 2015.<b>Aim:</b> The following article aims to investigate the safety and efficacy of direct cholangioscopy with laser lithotripsy in the treatment of CCL.<b>Materials and methods:</b> The study was conducted at the Department of General and Transplant Surgery, Medical University of Lodz. From October 2022 to November 2023, 13 procedures of difficult gallstone evacuation from the bile duct were performed using the technique of direct cholangioscopy with laser lithotripsy.<b>Results:</b> Thirteen cases of difficult gallstones were retrospectively analyzed. The bile duct was intubated via the ampulla of Vater using direct cholangioscopy. The bile duct was cleared of gallstones using laser lithotripsy, followed by a Dormia basket or an extraction balloon to remove stone fragments. The procedure was performed successfully in all patients. No complications were observed.<b>Conclusions:</b> DPOC with laser lithotripsy seems to be an effective and safe method of clearing even very large gallstones from the bile duct. The relatively low price of tools and the resulting cost reduction may allow this procedure to become more popular.

& lt; b>介绍:& lt; / b>胆总管结石(CCL)是胆总管结石最常见的严重健康后果之一。多年来,使用内镜逆行胆管造影(ERCP)清除结石一直是一线治疗方法。10-15%的病例不能用上述方法切除胆结石,需要辅助方法;这些是所谓的困难型胆结石。手术治疗有时是必要的。自2015年以来,欧洲胃肠内镜学会(ESGE)推荐使用胆道镜检查,包括直接经口胆道镜检查(DPOC)作为主要治疗方法之一。本文旨在探讨直接胆道镜联合激光碎石治疗CCL的安全性和有效性。材料和方法:这项研究是在罗兹医科大学普通外科和移植外科学系进行的。自2022年10月至2023年11月,采用直接胆道镜联合激光碎石技术,对13例胆管难治性胆结石进行了排尿。对13例难治性胆结石进行回顾性分析。直接胆管镜下经壶腹置管胆管。采用激光碎石清除胆管内的胆结石,随后采用睡眠篮筐或取出球囊去除结石碎片。所有患者手术均成功。无并发症发生。结论:<;/b>;DPOC与激光碎石似乎是一种有效和安全的方法,清除胆管中甚至非常大的胆结石。相对较低的工具价格和由此产生的成本降低可能使这种手术变得更受欢迎。
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