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Journal of Experimental & Clinical Cancer Research最新文献

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LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation. LARS通过亮氨酸依赖的PRIM2翻译和DNA复制激活促进骨肉瘤的增殖。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-14 DOI: 10.1186/s13046-026-03691-w
Guannan Bai, Lin Zhang, Manli Zhao, Jingyao Zhang, Wenhao Chen
{"title":"LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation.","authors":"Guannan Bai, Lin Zhang, Manli Zhao, Jingyao Zhang, Wenhao Chen","doi":"10.1186/s13046-026-03691-w","DOIUrl":"https://doi.org/10.1186/s13046-026-03691-w","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
USP1 driven mitotic dysregulation and PLK1 stabilization confer Lenvatinib resistance in hepatocellular carcinoma. USP1驱动的有丝分裂失调和PLK1稳定赋予肝细胞癌Lenvatinib耐药。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-13 DOI: 10.1186/s13046-026-03683-w
Yuwei Qiang, Saiyan Bian, Yun Tong, Weiting Chen, Zhangzhi Tang, Chengchen Dai, Mingyu Liu, Banglong Xu, Lihan Jiang, Kexin Ma, Xuyang He, Jinlong Li, Mingbing Xiao, Wenjie Zheng
{"title":"USP1 driven mitotic dysregulation and PLK1 stabilization confer Lenvatinib resistance in hepatocellular carcinoma.","authors":"Yuwei Qiang, Saiyan Bian, Yun Tong, Weiting Chen, Zhangzhi Tang, Chengchen Dai, Mingyu Liu, Banglong Xu, Lihan Jiang, Kexin Ma, Xuyang He, Jinlong Li, Mingbing Xiao, Wenjie Zheng","doi":"10.1186/s13046-026-03683-w","DOIUrl":"https://doi.org/10.1186/s13046-026-03683-w","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophils in solid cancers: sentinels, predictors, and therapeutic allies. 实体癌中的嗜酸性粒细胞：哨兵、预测因子和治疗同盟。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-12 DOI: 10.1186/s13046-026-03688-5
Marie Gilon, Delphine Boulet, Vincent Bours, Guy Jerusalem, Claire Josse, Christine Gennigens
{"title":"Eosinophils in solid cancers: sentinels, predictors, and therapeutic allies.","authors":"Marie Gilon, Delphine Boulet, Vincent Bours, Guy Jerusalem, Claire Josse, Christine Gennigens","doi":"10.1186/s13046-026-03688-5","DOIUrl":"https://doi.org/10.1186/s13046-026-03688-5","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combinatorial inhibition of IGF2BP3-regulated receptor tyrosine kinases offers a new therapeutic strategy for triple-negative breast cancer. 组合抑制igf2bp3调节的受体酪氨酸激酶为三阴性乳腺癌提供了一种新的治疗策略。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-11 DOI: 10.1186/s13046-026-03686-7
Zi-Wen Wang, Xu Zhang, Yu-Xin Wang, Meng-Yuan Cai, Jiao Chen, Ming-Yi Sang, Hai-Yan Yang, Liang Shi, Ji-Fu Wei, Qiang Ding
{"title":"Combinatorial inhibition of IGF2BP3-regulated receptor tyrosine kinases offers a new therapeutic strategy for triple-negative breast cancer.","authors":"Zi-Wen Wang, Xu Zhang, Yu-Xin Wang, Meng-Yuan Cai, Jiao Chen, Ming-Yi Sang, Hai-Yan Yang, Liang Shi, Ji-Fu Wei, Qiang Ding","doi":"10.1186/s13046-026-03686-7","DOIUrl":"https://doi.org/10.1186/s13046-026-03686-7","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the tumor microenvironment in drug resistance acquisition in lung squamous cell carcinoma. 肿瘤微环境在肺鳞癌耐药获得中的作用。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-04 DOI: 10.1186/s13046-026-03682-x
Oana Zanoaga, Cornelia Braicu, Andreea Nutu, Ioana Berindan-Neagoe, Andreas Bender
{"title":"The role of the tumor microenvironment in drug resistance acquisition in lung squamous cell carcinoma.","authors":"Oana Zanoaga, Cornelia Braicu, Andreea Nutu, Ioana Berindan-Neagoe, Andreas Bender","doi":"10.1186/s13046-026-03682-x","DOIUrl":"https://doi.org/10.1186/s13046-026-03682-x","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and advances in drug resistance and tolerance in cancer. 癌症耐药和耐药的挑战和进展。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-04 DOI: 10.1186/s13046-026-03665-y
Trever G Bivona, Itai Yanai, Fabio Calabrò, Fatima Mechta-Grigoriou, Giacomo Corleone, Marta Di Martile, Annalisa Tocci, Piera Tocci, Sebastiano Vaccarella, Marilia Consiglia Ferriero, Andrea Alimonti, Eytan Ruppin, Paola Nisticò, Anna Bagnato, Giovanni Blandino
{"title":"Challenges and advances in drug resistance and tolerance in cancer.","authors":"Trever G Bivona, Itai Yanai, Fabio Calabrò, Fatima Mechta-Grigoriou, Giacomo Corleone, Marta Di Martile, Annalisa Tocci, Piera Tocci, Sebastiano Vaccarella, Marilia Consiglia Ferriero, Andrea Alimonti, Eytan Ruppin, Paola Nisticò, Anna Bagnato, Giovanni Blandino","doi":"10.1186/s13046-026-03665-y","DOIUrl":"10.1186/s13046-026-03665-y","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":"45 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer. 突变体p53通过表观遗传方式重组CXCL10，促进CD8 + t细胞浸润，增强晚期前列腺癌患者的抗pd -1反应。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-03 DOI: 10.1186/s13046-026-03672-z
Jia Chen, Qintao Ge, Jun He, Zichen Bian, Haoming Yu, Chun Li, Jialin Meng, Shuiping Yin, Zongyao Hao, Chaozhao Liang, Meng Zhang
{"title":"Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer.","authors":"Jia Chen, Qintao Ge, Jun He, Zichen Bian, Haoming Yu, Chun Li, Jialin Meng, Shuiping Yin, Zongyao Hao, Chaozhao Liang, Meng Zhang","doi":"10.1186/s13046-026-03672-z","DOIUrl":"10.1186/s13046-026-03672-z","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-targeted IL2 promotes specific CD8+ T cells private clonal expansion enhancing lymphoma control. 肿瘤靶向il - 2促进CD8+ T细胞特异性克隆扩增，增强淋巴瘤控制。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-03 DOI: 10.1186/s13046-026-03678-7
T Virgilio, K Chahine, H Bansal, C Pizzichetti, L L Renner, A Capucetti, G Bilato, I Latino, D Morone, A Pulfer, P Ventura, F Mele, E Puca, D Mangani, C Junqueira, F Sallusto, D Neri, R De Luca, S F Gonzalez
{"title":"Tumor-targeted IL2 promotes specific CD8<sup>+</sup> T cells private clonal expansion enhancing lymphoma control.","authors":"T Virgilio, K Chahine, H Bansal, C Pizzichetti, L L Renner, A Capucetti, G Bilato, I Latino, D Morone, A Pulfer, P Ventura, F Mele, E Puca, D Mangani, C Junqueira, F Sallusto, D Neri, R De Luca, S F Gonzalez","doi":"10.1186/s13046-026-03678-7","DOIUrl":"https://doi.org/10.1186/s13046-026-03678-7","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methyl-cantharidimide suppresses cyclin-dependent kinase 1 (CDK1) and induces oxeiptosis in liver cancer. 甲基斑蝥素二胺抑制细胞周期蛋白依赖性激酶1 （CDK1）并诱导肝癌细胞凋亡。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-03-02 DOI: 10.1186/s13046-026-03669-8
Yi-Dong Li, Xiang Chen, Xing-Duo Dong, Zhiyong Ding, Zhe-Sheng Chen, Shuo Fang
{"title":"Methyl-cantharidimide suppresses cyclin-dependent kinase 1 (CDK1) and induces oxeiptosis in liver cancer.","authors":"Yi-Dong Li, Xiang Chen, Xing-Duo Dong, Zhiyong Ding, Zhe-Sheng Chen, Shuo Fang","doi":"10.1186/s13046-026-03669-8","DOIUrl":"https://doi.org/10.1186/s13046-026-03669-8","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SNRPC promotes chemoresistance in Wilms tumor via the NF-κB-CXCL17 axis regulating M2-Type TAMs infiltration and targeted nanotherapy research. SNRPC通过NF-κB-CXCL17轴调控m2型tam浸润及靶向纳米治疗研究促进Wilms肿瘤化疗耐药。
IF 12.8 1区 医学 Q1 ONCOLOGY
Journal of Experimental & Clinical Cancer Research
Pub Date : 2026-02-28 DOI: 10.1186/s13046-026-03680-z
Xiangpan Kong, Li Lei, Liming Jin, Chunnian Ren, Tao Mi, Quan Wang, Dawei He
{"title":"SNRPC promotes chemoresistance in Wilms tumor via the NF-κB-CXCL17 axis regulating M2-Type TAMs infiltration and targeted nanotherapy research.","authors":"Xiangpan Kong, Li Lei, Liming Jin, Chunnian Ren, Tao Mi, Quan Wang, Dawei He","doi":"10.1186/s13046-026-03680-z","DOIUrl":"https://doi.org/10.1186/s13046-026-03680-z","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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