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Health Care Providers' Attitudes and Knowledge Related to Tic Disorder Identification and Treatment. 医护人员对抽动障碍鉴别与治疗的态度与知识。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-16 DOI: 10.1097/DBP.0000000000001345
Kim Newsome, Helena J Hutchins, Rebecca H Bitsko, Lara R Robinson, Samuel M Katz, Nneoma Uba, Karyl T Rattay

Objective: Our study assessed child-serving health care providers' attitudes and knowledge related to identification and treatment of tic disorders including Tourette syndrome (TS), among children.

Methods: We analyzed cross-sectional data from the 2022 Fall DocStyles, a web-based survey of health care providers. The analytic sample included 1058 child-serving providers (403 family practitioners, 232 internists, 251 pediatricians, and 172 nurse practitioners or physician assistants). We calculated point prevalence estimates and 95% confidence intervals and used χ2 tests to statistically test differences by provider type and metro status of practice setting.

Results: Less than two-thirds of providers (62.4%) considered evaluation of tics as their role, less than half (40.8%) considered diagnosis of tic disorders their role, and around one-fourth considered treatment of patients with tic disorders to be their role (27.3%). Lack of knowledge of tics/TS and lack of comfort evaluating patients for tics and tic disorders were the most often reported barriers to identification and diagnosis for most provider types, and across practice metro status categories. Online training was the most preferred source of information about tics and tic disorders overall and for each provider type.

Conclusion: These findings support previous reports indicating challenges in health care provider comfort and knowledge in identifying and diagnosing tic disorders, and the need for more education opportunities around evaluation and diagnosis. Communication and training to support the needs of child-serving providers could improve the access to care for children with tics and tic disorders.

目的:本研究评估儿童服务卫生保健提供者对抽动障碍(包括抽动秽语综合征(TS))的识别和治疗的态度和知识。方法:我们分析了2022年秋季医生风格的横断面数据,这是一项基于网络的卫生保健提供者调查。分析样本包括1058名儿童服务提供者(403名家庭医生、232名内科医生、251名儿科医生和172名执业护士或医师助理)。我们计算了点患病率估计值和95%置信区间,并使用χ2检验统计检验不同提供者类型和大都市状态的执业环境的差异。结果:不到三分之二(62.4%)的医生认为抽动的评估是他们的职责,不到一半(40.8%)的医生认为抽动障碍的诊断是他们的职责,大约四分之一的医生认为抽动障碍患者的治疗是他们的职责(27.3%)。缺乏对抽动/TS的了解和缺乏对抽动和抽动障碍患者的舒适评估是大多数提供者类型和跨实践地铁状态类别中最常报道的识别和诊断障碍。在线培训是关于抽动和抽动障碍的最受欢迎的信息来源。结论:这些发现支持了先前的报告,表明卫生保健提供者在识别和诊断抽动障碍方面的舒适度和知识存在挑战,需要更多的评估和诊断教育机会。为满足儿童服务提供者的需求而进行的沟通和培训,可以改善患有抽动症和抽动障碍的儿童获得护理的机会。
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引用次数: 0
Social, Emotional, and Behavioral Functioning in Adolescents with Klinefelter Syndrome. 克氏综合症青少年的社会、情绪和行为功能。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001335
Anja L Jünger, Meagan Lasecke, Lara C Foland-Ross, Tracy L Jordan, Jamie L Sundstrom, Vanessa Lozano Wun, Gregory A Witkin, Chijioke Ikomi, Judith Ross, Allan L Reiss

Objective: Klinefelter syndrome (KS) is a common genetic condition in males associated with an extra X chromosome (i.e., 47,XXY). Individuals with KS often experience androgen insufficiency and tall stature and are at increased risk for depression, anxiety, and social challenges. This cross-sectional study investigates social and emotional functions in 52 boys with KS and 62 typically developing (TD) boys, aged 8 to 13 years.

Methods: Self-report measures of anxiety, depression, and behavior and parent-report measures of social functioning and behavior were completed. In primary analyses, linear regression was used to test the effect of group (KS, TD) on standardized scores derived from widely used rating scales. In secondary analyses, we explored the influence of pubertal status on these scores and concordance between self- and parent ratings.

Results: Our results indicate that boys with KS exhibit significantly increased anxiety, depression, and social difficulties relative to TD peers. Among participants with KS, peripubertal boys generally experienced more difficulties in aspects of social and emotional functioning as compared to prepubertal boys. Concordance analyses revealed differences between parent- and child-reports.

Conclusion: These findings indicate that alterations in social, emotional, and behavioral functions are present in boys and adolescents with KS and may be influenced by puberty.

目的:克氏综合征(Klinefelter syndrome, KS)是一种常见的男性遗传病,与一条额外的X染色体(即47,XXY)有关。患有KS的人通常会经历雄激素不足和身材高大,并且抑郁、焦虑和社交挑战的风险增加。本横断面研究调查了52名患有KS的男孩和62名8至13岁的典型发育(TD)男孩的社会和情感功能。方法:完成焦虑、抑郁和行为的自我报告测量以及社会功能和行为的父母报告测量。在初步分析中,使用线性回归来测试组(KS, TD)对广泛使用的评定量表的标准化得分的影响。在二次分析中,我们探讨了青春期状态对这些分数的影响以及自我和父母评分之间的一致性。结果:我们的研究结果表明,与TD同龄人相比,患有KS的男孩表现出明显增加的焦虑、抑郁和社交困难。在患有KS的参与者中,与青春期前的男孩相比,青春期周围的男孩通常在社交和情感功能方面经历了更多的困难。一致性分析揭示了父母和孩子报告之间的差异。结论:这些发现表明,社会、情感和行为功能的改变存在于男孩和青少年的KS中,并可能受到青春期的影响。
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引用次数: 0
All on the Same Team: Simulated Learning to Introduce Pediatric Residents to Interprofessional Collaboration with Individualized Education Program Teams. 所有人都在同一个团队:模拟学习向儿科住院医生介绍与个性化教育项目团队的跨专业合作。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001340
Tara J Minor, Rachel Goode

Objective: Our study sought to determine if participation in a simulated Individualized Education Program (IEP) meeting improved pediatric medical residents' attitudes toward the IEP team as an interprofessional health care team.

Methods: Pediatric medical residents on the Developmental-Behavioral and Advocacy rotations at an urban medical center participated in a simulated IEP eligibility meeting for a case of a fourth grader with a specific learning disability. Standardized actors portrayed the child's parent, principal, school psychologist, and classroom teacher. Residents were instructed to participate as members of the team. After participation, changes in the residents' readiness to participate on the IEP team were measured by the Interprofessional Socialization and Valuing Scale 9A (presimulation) and 9B (postsimulation).

Results: Sixty-six pediatric residents participated over 24 months. The mean scores of the aggregate pre- (4.92, SD = 0.83) and postsurveys (5.75, SD = 0.74) illustrated residents' improvement in 3 areas of interprofessional practice: understanding their role as a member of an IEP team; appreciation of an IEP team as an interprofessional health care team; and comfort and confidence in working as a member of an IEP team (Z = -6.37; p < 0.001; r = 0.78). Comparison of disaggregated data illustrated improvement for post-graduate year 1 (Z = -4.95; p < 0.001; r = 0.85) and categorical pediatric residents (Z = -5.86; p < 0.001; r = 0.83).

Conclusion: Simulated IEP meetings help pediatric residents reconceptualize their role in the school health of children with disabilities to include participation in and understanding of the IEP process.

目的:我们的研究旨在确定参加模拟个体化教育计划(IEP)会议是否能改善儿科住院医师对IEP团队作为跨专业医疗团队的态度。方法:在一个城市医疗中心进行发展-行为和倡导轮转的儿科住院医师参加了一个模拟的IEP资格会议,该会议针对一个患有特殊学习障碍的四年级学生。标准化的演员扮演孩子的父母、校长、学校心理学家和班主任。居民被指示作为小组成员参加。参与后,采用跨专业社会化与评估量表9A(模拟前)和9B(模拟后)测量居民参与IEP团队的意愿变化。结果:66名儿科住院医师参与了24个月。调查前(4.92,SD = 0.83)和调查后(5.75,SD = 0.74)的平均得分表明,居民在跨专业实践的3个方面有所改善:理解他们作为IEP团队成员的角色;赞赏IEP团队作为一个跨专业的卫生保健团队;以及作为IEP团队成员的舒适和信心(Z = -6.37;P < 0.001;R = 0.78)。分类数据比较表明,研究生一年级的情况有所改善(Z = -4.95;P < 0.001;r = 0.85)和儿科住院医师分类(Z = -5.86;P < 0.001;R = 0.83)。结论:模拟IEP会议有助于儿科住院医师重新定义他们在残疾儿童学校健康中的角色,包括参与和理解IEP过程。
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引用次数: 0
Neurodevelopmental and Mental Health Outcomes in a National Clinical Sample of Youth With Sex Chromosome Trisomies Compared With Matched Controls. 全国性染色体三体青年临床样本与匹配对照组的神经发育和心理健康结果比较
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001342
Adriana Hall, Anna Furniss, Nicole N Tartaglia, Jennifer Janusz, Rebecca Wilson, Caitlin Middleton, Sydney Martin, Jacqueline Frazier, Michele Martinez-Chadrom, Jennifer Hansen-Moore, Chijioke Ikomi, Judith Ross, Maria G Vogiaski, Leela Morrow, Dimitri A Christakis, Rachel E Lean, Natalie Nokoff, Laura Pyle, Shanlee M Davis

Objective: To compare the prevalence of neurodevelopmental and mental health diagnoses in a national sample of youth with sex chromosome trisomies (SCTs) with matched controls.

Methods: Patients in PEDSnet and a diagnosis code mapping to 47,XXY/Klinefelter syndrome (n = 1171), 47,XYY/Double Y syndrome (n = 243), or 47,XXX/Trisomy X syndrome (n = 262) were matched with controls using propensity scores. Generalized estimating equations computed odds ratios (OR) with 95% confidence intervals (CI) for the prevalence of diagnoses within the neurodevelopmental and mental health composites, psychotropic medication prescriptions, and encounters with behavioral health and therapy providers. Alpha was set at 0.0025 to account for multiple comparisons.

Results: Patients with SCTs had higher odds of diagnoses within the neurodevelopmental (OR 6.3, 95% CI, 5.7-7.2) and mental health composites (OR 2.7, 95% CI, 2.3-3.2) compared with matched controls. All neurodevelopmental diagnoses were more prevalent among all SCT groups compared with controls. Within the mental health composite, only the prevalence of anxiety and mood disorder was higher in all SCT groups. A higher proportion of patients with SCTs had psychotropic prescriptions compared with controls (stimulants 13.1% vs 5.2%, selective serotonin reuptake inhibitors 8.7% vs 2.8%, antipsychotics 6.5% vs 2.4%, p < 0.0001 for all). Overall, 48% of patients with SCTs had a clinical encounter with a behavioral health provider vs 16.6% of controls (OR 5.6, 95% CI, 4.1-5.1).

Conclusion: Compared with matched controls, youth with SCTs receiving care at US tertiary care pediatric centers have disproportionately high rates of neurodevelopmental and mental health conditions, emphasizing the need for appropriate screening and intervention in these populations.

目的:比较全国性染色体三体(SCTs)青少年与匹配对照组的神经发育和心理健康诊断的患病率。方法:使用倾向评分将PEDSnet中诊断代码为47、XXY/Klinefelter综合征(n = 1171)、47、XYY/双Y综合征(n = 243)或47、XXX/ X三体综合征(n = 262)的患者与对照组进行匹配。广义估计方程以95%置信区间(CI)计算了神经发育和心理健康组合、精神药物处方以及与行为健康和治疗提供者的接触中诊断的患病率的比值比(OR)。Alpha值设为0.0025以考虑多重比较。结果:与匹配的对照组相比,sct患者在神经发育(OR 6.3, 95% CI, 5.7-7.2)和精神健康(OR 2.7, 95% CI, 2.3-3.2)方面的诊断几率更高。与对照组相比,所有SCT组的所有神经发育诊断都更为普遍。在心理健康综合指标中,所有SCT组中只有焦虑和情绪障碍的患病率较高。与对照组相比,sct患者服用精神药物处方的比例更高(兴奋剂13.1%对5.2%,选择性血清素再摄取抑制剂8.7%对2.8%,抗精神病药物6.5%对2.4%,p < 0.0001)。总体而言,48%的sct患者与行为健康提供者有临床接触,而对照组为16.6% (OR 5.6, 95% CI, 4.1-5.1)。结论:与对照组相比,在美国三级儿科护理中心接受sct治疗的青少年神经发育和精神健康状况的发生率高得不成比例,这强调了对这些人群进行适当筛查和干预的必要性。
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引用次数: 0
Improving Resident Physician History and Physical in Challenging Situations. 在具有挑战性的情况下改善住院医师的病史和身体状况。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001341
Nicholas Rockwell, Nancy M Tofil, Chrystal Rutledge, Stacy L Gaither, Carrie Norwood, J Lynn Zinkan, Inmaculada Aban, James Willig, Michele Kong

Objective: To educate physician trainees using simulation on best management of children with autism spectrum disorder who have neurocognitive and behavioral challenges when experiencing acute illness.

Method: A simulation-based curriculum including baseline assessment, communication techniques, and use of calming resources was developed to educate residents in assessing children with sensory barriers. Traditional simulation and deliberate practice were used to teach this curriculum to second- and third-year pediatric and internal medicine-pediatric residents. Using alternating assignment, residents were placed into 3 groups: deliberate practice, traditional simulation-based debriefing, and control (no simulation training). The residents were assessed on the initial visit, 2 weeks and 4 to 6 months follow-up periods with a sensory assessment tool. Assessment scores were analyzed using a general linear mixed model with random intercept based on Poisson regression to approximate distribution of the total score.

Results: Forty-three residents participated: 46.5% men, 53.5% women. There were 15, 16, and 12 residents in the control, deliberate practice and traditional simulation groups, respectively. Both teaching styles showed improved performance at 2 weeks follow-up. In addition, these groups demonstrated higher performance when compared with the control group. We were able to show that resident physicians were able to learn important principles and retain them during 4 to 6 months follow-up. However, there was not a difference between 2 teaching styles both in improvement and retention.

Conclusion: Simulation education, both deliberate and traditional, can be used to enhance teaching of key components in assessing children with sensory and communication barriers, including those with autism spectrum disorder when presenting with acute illness.

目的:通过模拟的方法对临床实习医师进行培训,使其了解急性自闭症谱系障碍患儿神经认知和行为障碍的最佳处理方法。方法:以模拟为基础的课程,包括基线评估、沟通技巧和镇静资源的使用,以教育居民评估有感官障碍的儿童。传统的模拟和刻意练习被用于向二年级和三年级的儿科和内科儿科住院医师教授该课程。采用交替分配的方法,住院医生被分为3组:刻意练习组、传统的基于模拟的汇报组和对照组(没有模拟训练)。使用感官评估工具在初次访问、2周和4至6个月的随访期间对居民进行评估。评估分数采用基于泊松回归的随机截距的一般线性混合模型进行分析,以近似总分的分布。结果:43名居民参与,其中男性46.5%,女性53.5%。对照组、刻意练习组和传统模拟组分别为15人、16人和12人。两种教学方式在2周的随访中均有改善。此外,与对照组相比,这些组表现出更高的表现。我们能够证明住院医师能够学习重要的原则并在4到6个月的随访中保留它们。然而,两种教学方式在提高和保持方面没有差异。结论:模拟教学可用于评估感觉和沟通障碍儿童(包括自闭症谱系障碍儿童)在急性疾病表现时的关键要素教学。
{"title":"Improving Resident Physician History and Physical in Challenging Situations.","authors":"Nicholas Rockwell, Nancy M Tofil, Chrystal Rutledge, Stacy L Gaither, Carrie Norwood, J Lynn Zinkan, Inmaculada Aban, James Willig, Michele Kong","doi":"10.1097/DBP.0000000000001341","DOIUrl":"https://doi.org/10.1097/DBP.0000000000001341","url":null,"abstract":"<p><strong>Objective: </strong>To educate physician trainees using simulation on best management of children with autism spectrum disorder who have neurocognitive and behavioral challenges when experiencing acute illness.</p><p><strong>Method: </strong>A simulation-based curriculum including baseline assessment, communication techniques, and use of calming resources was developed to educate residents in assessing children with sensory barriers. Traditional simulation and deliberate practice were used to teach this curriculum to second- and third-year pediatric and internal medicine-pediatric residents. Using alternating assignment, residents were placed into 3 groups: deliberate practice, traditional simulation-based debriefing, and control (no simulation training). The residents were assessed on the initial visit, 2 weeks and 4 to 6 months follow-up periods with a sensory assessment tool. Assessment scores were analyzed using a general linear mixed model with random intercept based on Poisson regression to approximate distribution of the total score.</p><p><strong>Results: </strong>Forty-three residents participated: 46.5% men, 53.5% women. There were 15, 16, and 12 residents in the control, deliberate practice and traditional simulation groups, respectively. Both teaching styles showed improved performance at 2 weeks follow-up. In addition, these groups demonstrated higher performance when compared with the control group. We were able to show that resident physicians were able to learn important principles and retain them during 4 to 6 months follow-up. However, there was not a difference between 2 teaching styles both in improvement and retention.</p><p><strong>Conclusion: </strong>Simulation education, both deliberate and traditional, can be used to enhance teaching of key components in assessing children with sensory and communication barriers, including those with autism spectrum disorder when presenting with acute illness.</p>","PeriodicalId":50215,"journal":{"name":"Journal of Developmental and Behavioral Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parents' Experiences and Views About Use of Wearable Technology for Research and Treatment Monitoring of Children with Neurodevelopmental Disorders. 家长对可穿戴技术应用于神经发育障碍儿童研究与治疗监测的经验与看法
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001337
Rachel Xifaras, David J Amor, Erin Turbitt, Claudine M Kraan

Objective: Wearable technology has potential benefits for clinical measurement with children who have neurodevelopmental disorders (NDDs). However, this cohort may experience sensory processing disorder, behavioral dysregulation, and cognitive challenges. For effective and considerate implementation, the experiences and views of parents of children with NDDs on this topic need in-depth investigation.

Method: This qualitative semi-structured interview study used purposeful sampling of families with experience with wearable technology in a research setting. The cohort included 12 parents of 14 children with a diagnosis of Fragile X (n = 6), Prader-Willi (n = 4), or Angelman (n = 4) syndromes. The data were processed using NVivo software (QSR International Ltd. 1999-2013). Data analysis was conducted using reflexive thematic analysis.

Results: Theme 1: Parents are willing to use wearable technology in the home or community if it is feasible. Aspects of feasibility were the ease of embedding technology into existing routines, device robustness, and device invasiveness. Theme 2: Parents are guided by previous healthcare and research experiences. Wearables were considered low burden in the context of everything else their child experiences through health care. Theme 3: Early engagement with families in the design and research process of new technologies is important. Parents had strong views on how to introduce a wearable to their child. In this article, parents stressed that the child's behavioral phenotype needs to be considered early in the design and rollout phases.

Conclusion: A shared decision-making approach between researchers and parents will improve the uptake and success of NDD-focused research adopting wearable technology approaches for clinical measurement.

目的:可穿戴技术在儿童神经发育障碍(ndd)的临床测量中具有潜在的益处。然而,这群人可能会经历感觉加工障碍、行为失调和认知挑战。为了有效、周到地实施,需要深入调查ndd患儿家长在这一问题上的经验和看法。方法:这个定性的半结构化访谈研究在研究环境中对有可穿戴技术经验的家庭进行了有目的的抽样。该队列包括12对父母,14名儿童被诊断为脆性X综合征(n = 6)、Prader-Willi综合征(n = 4)或Angelman综合征(n = 4)。数据采用NVivo软件(QSR International Ltd. 1999-2013)处理。数据分析采用反身性主题分析。结果:主题1:如果可行,家长愿意在家中或社区使用可穿戴技术。可行性方面是将技术嵌入现有例程的便利性、设备的健壮性和设备的侵入性。主题2:父母以以往的医疗和研究经验为指导。在他们的孩子通过医疗保健经历的所有其他事情的背景下,可穿戴设备被认为是低负担。主题3:尽早让家庭参与新技术的设计和研究过程非常重要。家长们对如何给孩子介绍可穿戴设备有着强烈的看法。在这篇文章中,家长们强调,孩子的行为表现型需要在设计和推出阶段的早期考虑。结论:研究人员和家长之间的共同决策方法将提高采用可穿戴技术方法进行临床测量的ndd研究的吸收和成功。
{"title":"Parents' Experiences and Views About Use of Wearable Technology for Research and Treatment Monitoring of Children with Neurodevelopmental Disorders.","authors":"Rachel Xifaras, David J Amor, Erin Turbitt, Claudine M Kraan","doi":"10.1097/DBP.0000000000001337","DOIUrl":"10.1097/DBP.0000000000001337","url":null,"abstract":"<p><strong>Objective: </strong>Wearable technology has potential benefits for clinical measurement with children who have neurodevelopmental disorders (NDDs). However, this cohort may experience sensory processing disorder, behavioral dysregulation, and cognitive challenges. For effective and considerate implementation, the experiences and views of parents of children with NDDs on this topic need in-depth investigation.</p><p><strong>Method: </strong>This qualitative semi-structured interview study used purposeful sampling of families with experience with wearable technology in a research setting. The cohort included 12 parents of 14 children with a diagnosis of Fragile X (n = 6), Prader-Willi (n = 4), or Angelman (n = 4) syndromes. The data were processed using NVivo software (QSR International Ltd. 1999-2013). Data analysis was conducted using reflexive thematic analysis.</p><p><strong>Results: </strong>Theme 1: Parents are willing to use wearable technology in the home or community if it is feasible. Aspects of feasibility were the ease of embedding technology into existing routines, device robustness, and device invasiveness. Theme 2: Parents are guided by previous healthcare and research experiences. Wearables were considered low burden in the context of everything else their child experiences through health care. Theme 3: Early engagement with families in the design and research process of new technologies is important. Parents had strong views on how to introduce a wearable to their child. In this article, parents stressed that the child's behavioral phenotype needs to be considered early in the design and rollout phases.</p><p><strong>Conclusion: </strong>A shared decision-making approach between researchers and parents will improve the uptake and success of NDD-focused research adopting wearable technology approaches for clinical measurement.</p>","PeriodicalId":50215,"journal":{"name":"Journal of Developmental and Behavioral Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Childhood Adversity on the Relationship Between Family Resilience and Behavioral or Conduct Problems in Children With Special Healthcare Needs. 童年逆境对特殊保健需要儿童家庭弹性与行为或品行问题关系的影响
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001343
Suman Kanti Chowdhury, Rihana Aaliyah Aydin, Harsha Puri, Suruthi Sundaramurugan, Nagashree Ravi Rao, Haille Skinner, Rachel Sauls, Dowensly Jean Brice, Steven Tsang, Chighaf Bakour, Russell S Kirby

Objective: Behavioral or conduct problems (BCPs) are common co-occurring conditions in children with special health care needs (CSHCNs), affecting their developmental and functional milestones. The role of family resilience in mitigating BCPs among these children and how adverse childhood experiences (ACEs) affect this dynamic remain largely unclear. The aim of the study was to disentangle the complex interplay between family resilience, ACEs, and BCPs by examining how ACEs moderate the relationship between family resilience and BCPs.

Methods: The study included 19,922 CSHCNs aged 3 to 17 years from the 2020-2021 National Survey of Children's Health. Weighted analysis was conducted using the Rao-Scott χ2 test and multivariable logistic regression to account for the complex survey design.

Results: Children from families with no and low resilience as compared with high-resilient families had 1.78 times (odds ratio [OR]: 1.78, 95% confidence interval [CI], 1.31-2.43) and 1.44 times (OR: 1.44, 95% CI, 1.18-1.76) higher odds of BCPs, respectively. While the odds of BCPs decreased in nonresilient families as ACEs increased from none to 1 ACE, 2 or more ACEs versus no ACE increased the odds of BCPs in low-resilient families from 1.42 times (OR: 1.42, 95% CI, 1.03-1.94) to 1.51 times (OR: 1.51, 95% CI, 1.13-2.02).

Conclusion: The findings suggest that family resilience is associated with a lower likelihood of BCPs in CSHCNs. ACEs have varying effects on the relationship between family resilience and BCPs across different levels of family resilience. These results highlight the importance of strengthening family resilience and addressing ACEs in interventions to reduce behavioral issues in CSHCNs.

目的:行为或行为问题(BCPs)是有特殊卫生保健需求儿童(CSHCNs)中常见的共同发生的疾病,影响他们的发育和功能里程碑。家庭弹性在减轻这些儿童的bcp中的作用,以及不良童年经历(ace)如何影响这一动态在很大程度上仍不清楚。本研究的目的是通过考察ace如何调节家庭弹性和bcp之间的关系,来解开家庭弹性、ace和bcp之间复杂的相互作用。方法:该研究纳入了2020-2021年全国儿童健康调查中3至17岁的19,922名CSHCNs。采用Rao-Scott χ2检验和多变量logistic回归进行加权分析,以解释复杂的调查设计。结果:无弹性和低弹性家庭的儿童与高弹性家庭的儿童相比,bcp的发生率分别高出1.78倍(比值比[OR]: 1.78, 95%可信区间[CI], 1.31-2.43)和1.44倍(OR: 1.44, 95% CI, 1.18-1.76)。当ACE从无增加到1次ACE时,非弹性家庭bcp的几率降低,而2次或更多ACE与无ACE相比,低弹性家庭bcp的几率从1.42倍(or: 1.42, 95% CI, 1.03-1.94)增加到1.51倍(or: 1.51, 95% CI, 1.13-2.02)。结论:研究结果表明,家庭恢复力与CSHCNs中较低的bcp可能性有关。在不同的家庭弹性水平上,应激反应对家庭弹性与心理能力的关系有不同的影响。这些结果强调了在干预措施中加强家庭复原力和解决ace的重要性,以减少CSHCNs的行为问题。
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引用次数: 0
Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study. 谷胱甘肽、维生素C和半胱氨酸在患有破坏性行为的自闭症儿童中的应用:一项双盲、安慰剂对照的交叉试验研究。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001334
Patricia Gail Williams, Lonnie Sears, Walter H Watson, Bakeerathan Gunaratnam, Yana Feygin, Stephen P Wright, Janice E Sullivan

Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.

Methods: Glutathione and glutathione in combination with vitamin C and N-acetylcysteine (Trio) were tested. Both treatments were administered in double-blind placebo-controlled randomized crossover studies. In total, 24 children between the ages of 5 and 16 years with ASD and severe behavior disorders were randomized to receive weekly intravenous injections of either placebo or 1 of the 2 interventions (glutathione or Trio) for 8 weeks. After a 1-week washout period, participants were crossed over for the subsequent 8 weeks. Behavioral measures and plasma levels of glutathione were obtained at baseline, during the washout period, and at the end of the study.

Results: No differences between treatment groups in behavioral or biologic measures were found. No significant adverse side effects attributable to the treatments were observed. Small improvements in specific glutathione and behavioral measures occurred over the study period for all groups.

Conclusion: Treatment with glutathione or glutathione in combination with vitamin C and N-acetylcysteine did not result in improvements in behavior or biologic measures. The positive trends over the course of the study were likely due to the placebo effect or decreased anxiety associated with the study routine.

目的:自闭症谱系障碍(Autism spectrum disorder, ASD)是一种以社会交际差异和兴趣限制为特征的复杂神经发育疾病。一种被提出的ASD的生物学机制是氧化应激,根据自闭症儿童行为改善的轶事报道,导致临床使用谷胱甘肽。在这项初步研究中,我们采用随机临床试验的形式来验证这一观察结果,以收集有关谷胱甘肽安全性和有效性的初步数据。方法:对谷胱甘肽及谷胱甘肽与维生素C、n -乙酰半胱氨酸(Trio)联合用药进行检测。两种治疗均在双盲安慰剂对照随机交叉研究中进行。总共有24名年龄在5到16岁之间的患有ASD和严重行为障碍的儿童被随机分配,每周静脉注射安慰剂或两种干预措施中的一种(谷胱甘肽或Trio),持续8周。经过一周的洗脱期后,参与者被交叉进行随后的8周。在基线、洗脱期和研究结束时获得行为测量和谷胱甘肽的血浆水平。结果:两组在行为和生物学指标上均无差异。未观察到治疗引起的显著不良副作用。在研究期间,所有组在特定谷胱甘肽和行为测量方面都有小幅改善。结论:谷胱甘肽或谷胱甘肽联合维生素C和n -乙酰半胱氨酸治疗并没有导致行为或生物学指标的改善。研究过程中的积极趋势可能是由于安慰剂效应或与研究常规相关的焦虑减少。
{"title":"Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study.","authors":"Patricia Gail Williams, Lonnie Sears, Walter H Watson, Bakeerathan Gunaratnam, Yana Feygin, Stephen P Wright, Janice E Sullivan","doi":"10.1097/DBP.0000000000001334","DOIUrl":"10.1097/DBP.0000000000001334","url":null,"abstract":"<p><strong>Objective: </strong>Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.</p><p><strong>Methods: </strong>Glutathione and glutathione in combination with vitamin C and N-acetylcysteine (Trio) were tested. Both treatments were administered in double-blind placebo-controlled randomized crossover studies. In total, 24 children between the ages of 5 and 16 years with ASD and severe behavior disorders were randomized to receive weekly intravenous injections of either placebo or 1 of the 2 interventions (glutathione or Trio) for 8 weeks. After a 1-week washout period, participants were crossed over for the subsequent 8 weeks. Behavioral measures and plasma levels of glutathione were obtained at baseline, during the washout period, and at the end of the study.</p><p><strong>Results: </strong>No differences between treatment groups in behavioral or biologic measures were found. No significant adverse side effects attributable to the treatments were observed. Small improvements in specific glutathione and behavioral measures occurred over the study period for all groups.</p><p><strong>Conclusion: </strong>Treatment with glutathione or glutathione in combination with vitamin C and N-acetylcysteine did not result in improvements in behavior or biologic measures. The positive trends over the course of the study were likely due to the placebo effect or decreased anxiety associated with the study routine.</p>","PeriodicalId":50215,"journal":{"name":"Journal of Developmental and Behavioral Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embedding Universal Language Promotion in Pediatric Primary Care to Optimize Early Child Development and Reduce Long-Term Health Disparities. 在儿科初级保健中推广通用语言,优化儿童早期发展,减少长期健康差距。
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-09 DOI: 10.1097/DBP.0000000000001344
Brenda Salley, Heather von Bevern, Nicolette Grasley-Boy, Kandace Fleming, Kirsten Weltmer, Judith Carta

Objective: To report on the feasibility and outcomes of universal language promotion intervention (Talk With Me Baby [TWMB]) embedded within routine well-child care for children from birth to 3-years old.

Methods: Across 2 primary care clinics, 29 health care team members participated in a 12-month trial to deliver TWMB within well-child care visits. Feasibility was based on clinician feedback during the trial, clinician knowledge assessments, and clinic data. Sixty-three parents and their infant/toddlers were enrolled to provide feedback on TWMB and to assess parent language promotion behaviors, specifically, parents' self-reported use of their language-building interactions during daily activities with their child.

Results: Clinician feedback and clinic data support TWMB as an acceptable and feasible intervention that can be used successfully within standard of care well-child visits by health care teams. Initial outcome data show positive changes for increasing parent-child language promoting interactions during daily activities.

Conclusion: Results support the promise of leveraging primary care as a low-cost, scalable way to deliver universal language promotion intervention to optimize the developmental potential of all young children.

目的:探讨将通用语言促进干预(Talk With Me Baby [TWMB])纳入出生至3岁儿童常规保育的可行性和效果。方法:在2个初级保健诊所,29名卫生保健团队成员参加了一项为期12个月的试验,在儿童保健就诊期间提供TWMB。可行性基于临床医生在试验期间的反馈、临床医生知识评估和临床数据。本研究招募了63位家长和他们的婴幼儿,以提供TWMB的反馈,并评估父母的语言促进行为,特别是父母在日常活动中与孩子进行语言建设互动的自我报告。结果:临床医生反馈和临床数据支持TWMB是一种可接受和可行的干预措施,可以在卫生保健团队的标准护理中成功使用。初步结果数据显示,在日常活动中增加亲子语言促进互动的积极变化。结论:结果支持利用初级保健作为一种低成本、可扩展的方式来提供普遍语言促进干预,以优化所有幼儿的发展潜力。
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引用次数: 0
Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study.
IF 1.8 3区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.1097/DBP.0000000000001334
Patricia Gail Williams, Lonnie Sears, Walter H Watson, Bakeerathan Gunaratnam, Yana Feygin, Stephen P Wright, Janice E Sullivan

Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.

Methods: Glutathione and glutathione in combination with vitamin C and N-acetylcysteine (Trio) were tested. Both treatments were administered in double-blind placebo-controlled randomized crossover studies. In total, 24 children between the ages of 5 and 16 years with ASD and severe behavior disorders were randomized to receive weekly intravenous injections of either placebo or 1 of the 2 interventions (glutathione or Trio) for 8 weeks. After a 1-week washout period, participants were crossed over for the subsequent 8 weeks. Behavioral measures and plasma levels of glutathione were obtained at baseline, during the washout period, and at the end of the study.

Results: No differences between treatment groups in behavioral or biologic measures were found. No significant adverse side effects attributable to the treatments were observed. Small improvements in specific glutathione and behavioral measures occurred over the study period for all groups.

Conclusion: Treatment with glutathione or glutathione in combination with vitamin C and N-acetylcysteine did not result in improvements in behavior or biologic measures. The positive trends over the course of the study were likely due to the placebo effect or decreased anxiety associated with the study routine.

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引用次数: 0
期刊
Journal of Developmental and Behavioral Pediatrics
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