Journal of Clinical Densitometry最新文献_第5页

Changes in lean mass and fat mass in children with Osteogenesis Imperfecta 成骨不全症患儿瘦脂肪量的变化

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1016/j.jocd.2025.101605

Holly Wright , Sze Choong Wong , Misha Gilani , Helen McDevitt , Sheila Shepherd , Avril Mason

Background: Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.

Methodology: Data was collected from 29 children, with a diagnosis of OI, who had at least two dual-energy x-ray absorptiometry (DXA) scans performed between 2015 and 2022. Assessed variables of height, body mass index (BMI), lean mass index (LMI) and fat mass index (FMI), were converted to z scores. Results were reported as median (range).

Results: Median age at baseline and follow-up were 10.7 and 14.2 years, respectively. Median height z-score at baseline was -1.10, which was significantly lower than a control population (p<0.001). Median height z-score at latest follow-up was -0.80, which was not significantly different from baseline (p=0.870). Median BMI z-score at baseline was 0.15, which was not significantly different than a control population (p=0.804). Median BMI z-score at latest follow-up was 0.02, which was not significantly different from baseline (p=0.730). At baseline, median LMI z-score was -2.43, which was significantly lower than a control population (p<0.001). Median LMI z-score at follow-up was -1.78, which was not significantly different from baseline (p=0.080). At baseline, median FMI z-score was 0.57 which was significantly higher than a control population (p=0.001). Median FMI z-score at follow-up was 0.62, which was not significantly different from baseline (p=0.540).

Conclusion: Children with OI have abnormal body composition throughout childhood typically with low lean mass and relatively high fat mass. These abnormalities in body composition do not change with follow-up. Strategies to improve lean mass, including physical or medical therapies, should be explored in OI given the close relationship between muscle and bone.

背景：骨骼肌和功能缺陷，以及由此导致的身体成分异常，是成骨不全症（OI）的一个公认特征。对于成骨不全患者体内成分的纵向变化了解较少。我们的目的是对成骨不全儿童身体组成（瘦质量和脂肪质量）的纵向变化进行回顾性分析。方法：收集29名诊断为成骨不全的儿童的数据，这些儿童在2015年至2022年期间至少进行了两次双能x线吸收仪（DXA）扫描。评估变量身高、身体质量指数（BMI）、瘦质量指数（LMI）和脂肪质量指数（FMI）转换为z分数。结果以中位数（范围）报告。结果：基线和随访时的中位年龄分别为10.7岁和14.2岁。基线时身高z得分中位数为-1.10，显著低于对照人群（p<0.001）。最新随访中位身高z得分为-0.80，与基线无显著差异（p=0.870）。基线时BMI z评分中位数为0.15，与对照组相比差异无统计学意义（p=0.804）。最新随访时BMI z评分中位数为0.02，与基线无显著差异（p=0.730）。基线时，LMI z-score中位数为-2.43，显著低于对照组（p<0.001）。随访时LMI z-score中位数为-1.78，与基线无显著差异（p=0.080）。基线时，FMI z-score中位数为0.57，显著高于对照组（p=0.001）。随访时FMI z-score中位数为0.62，与基线无显著差异（p=0.540）。结论：成骨不全儿童在整个儿童期均存在身体成分异常，典型表现为低瘦体质量和相对高脂体质量。这些身体成分的异常不随随访而改变。考虑到肌肉和骨骼之间的密切关系，在成骨不全症中应该探索改善瘦质量的策略，包括物理或药物治疗。

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引用次数: 0

Bone health ECHO case report: Normocalcemic hyperparathyroidism in a patient with osteoporosis referred for pre-operative bone health evaluation before spine surgery 骨健康ECHO病例报告：骨质疏松症患者的正常钙血症甲状旁腺功能亢进在脊柱手术前进行术前骨健康评估

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-06-16 DOI: 10.1016/j.jocd.2025.101600

Danielle D’Annibale , E. Michael Lewiecki , Gina Woods

Primary hyperparathyroidism can be divided into three clinical phenotypes: classical primary hyperparathyroidism with hypercalcemia and target organ involvement, asymptomatic primary hyperparathyroidism with hypercalcemia, and normocalcemic primary hyperparathyroidism. The latter phenotype is being increasingly recognized in patients having serum parathyroid hormone levels measured as part of the initial evaluation of osteoporosis. The diagnosis of normocalcemic primary hyperparathyroidism requires exclusion of secondary causes of parathyroid hormone elevation, such an vitamin D deficiency and calcium malabsorption. There is no consensus on the management of patients with normocalcemic primary hyperparathyroidism, particularly with regard to consideration of parathyroid surgery versus clinical observation. This is a case report of a patient with persistently normal calcium levels, high parathyroid hormone, and no recognized cause of secondary hyperparathyroidism. This case was presented and discussed at Bone Health Extension for Community Healthcare Outcomes, a virtual community of practice that has been meeting online weekly since 2015.

原发性甲状旁腺功能亢进可分为三种临床表型：典型原发性甲状旁腺功能亢进伴高钙血症及累及靶器官、无症状原发性甲状旁腺功能亢进伴高钙血症和正常血钙血症原发性甲状旁腺功能亢进。作为骨质疏松症初步评估的一部分，测量血清甲状旁腺激素水平的患者越来越多地认识到后一种表型。正常血钙水平原发性甲状旁腺功能亢进的诊断需要排除甲状旁腺激素升高的继发原因，如维生素D缺乏和钙吸收不良。对于正常血钙水平的原发性甲状旁腺功能亢进患者的治疗，特别是甲状旁腺手术与临床观察的比较，目前尚无共识。这是一个病例报告的病人持续正常的钙水平，高甲状旁腺激素，继发性甲状旁腺功能亢进没有明确的原因。该病例在骨骼健康扩展社区医疗保健结果上进行了介绍和讨论，这是一个自2015年以来每周在线会议的虚拟实践社区。

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引用次数: 0

Composite Indices of Femoral Neck Strength in Young Adult Male Volleyball Players 青年男子排球运动员股骨颈力量综合指标研究

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI: 10.1016/j.jocd.2025.101622

Ibrahim Fayad, Antonio Pinti, Hassane Zouhal, Rawad El Hage

引用次数: 0

Association Between Cognitive Functions and Bone Health in the Elderly: The NHANES, 2013-2014 老年人认知功能与骨骼健康之间的关系：NHANES， 2013-2014。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-09-16 DOI: 10.1016/j.jocd.2025.101626

Sumbal Javaid , Qi Meng , Xinwei Wang , Chao Ma , Yanlin Duan , Shuman Yang

We examined the association of cognitive function with bone mineral density (BMD), osteoporosis, and osteopenia. We identified 1070 participants (528 men) aged ≥60 years or older from the NHANES, 2013-2014. BMD was measured using dual-energy X-ray absorptiometry (DXA). Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning sub-test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). After adjusting for covariates, one standard deviation increase in the DSST score was associated with increased BMD of the total hip (β = 0.022, P = 0.007), femoral neck (β = 0.024 P = 0.004), and lumbar spine (β = 0.025, P = 0.005) in females. When comparing females in the highest quartile of the DSST score to those in the lowest quartile, the highest score group was associated with a lower risk of osteoporosis [odds ratio (OR), 0.25; 95 % CI, 0.09–0.70] and osteopenia [OR, 0.35 (0.16–0.76)]. No associations were found between the CERAD test, Animal Fluency test, and bone health in females, or between cognitive function and bone health in males. In conclusion, higher DSST scores were associated with higher BMD and lower risk of osteoporosis and osteopenia in elderly females.

我们研究了认知功能与骨密度（BMD）、骨质疏松症和骨质减少症的关系。我们从2013-2014年的NHANES中选取了1070名年龄≥60岁的参与者（528名男性）。采用双能x线骨密度仪（DXA）测量骨密度。认知功能通过建立阿尔茨海默病注册中心（CERAD）单词学习子测试、动物流畅性测试和数字符号替代测试（DSST）进行评估。在调整协变量后，DSST评分的一个标准差增加与女性全髋（β = 0.022, P = 0.007）、股骨颈（β = 0.024 P = 0.004）和腰椎（β = 0.025, P = 0.005）的骨密度增加相关。当比较DSST评分最高四分位数的女性与最低四分位数的女性时，得分最高的组与骨质疏松症的风险较低相关[比值比（OR）， 0.25；95% CI, 0.09-0.70]和骨质减少[OR， 0.35(0.16-0.76)]。没有发现CERAD测试、动物流畅性测试和女性骨骼健康之间的关联，也没有发现男性认知功能和骨骼健康之间的关联。综上所述，DSST评分越高，老年女性的骨密度越高，骨质疏松和骨质减少的风险越低。

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引用次数: 0

Sacral Slope as an Early Marker of Postural Change in Postmenopausal Women with Low Bone Mass 骶骨倾斜是绝经后低骨量妇女体位变化的早期标志。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-09-17 DOI: 10.1016/j.jocd.2025.101627

Benil Nesli ATA , Ece CINAR

Objectives: To assess the relationship between bone mineral density (BMD) and sagittal spinopelvic alignment in postmenopausal women with low bone mass.

Methods: Ninety-two postmenopausal women diagnosed with osteopenia or osteoporosis based on DEXA T-scores were retrospectively analyzed. Spinopelvic parameters—sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI), and lumbar lordosis (LL)—were measured using lateral radiographs. Clinical and demographic variables were compared between groups using appropriate statistical methods.

Results: Among all parameters, only SS showed a statistically significant difference between osteoporotic and osteopenic women (p = 0.037). No significant correlations were found between BMD and parity, menopause age, or vitamin D levels. Osteoporotic women had lower SS values. Other spinopelvic and demographic parameters did not differ significantly between groups.

Conclusion: Alterations in SS may represent early postural and biomechanical adaptations to declining bone strength in postmenopausal women. As a determinant of sagittal alignment, SS influences pelvic orientation and lumbar curvature. Its reduction may signal a forward shift in the center of gravity, increasing fall risk. Incorporating SS evaluation into standard imaging may aid early identification of at-risk individuals. Prospective studies are needed to confirm its clinical relevance and predictive value for fractures and functional decline.

目的：探讨绝经后低骨量妇女骨密度与矢状椎盂排列的关系。方法：回顾性分析92例经DEXA t评分诊断为骨质减少或骨质疏松的绝经后妇女。脊柱参数-骶骨斜率（SS），骨盆倾斜（PT），骨盆发生率（PI）和腰椎前凸(LL)-通过侧位x线片测量。采用适当的统计学方法比较两组间的临床和人口学变量。结果：在所有参数中，骨质疏松症和骨质减少症女性只有SS有统计学差异（p = 0.037）。骨密度与胎次、绝经年龄或维生素D水平之间没有显著相关性。骨质疏松女性SS值较低。其他脊柱和人口学参数在组间无显著差异。结论：SS的改变可能代表绝经后妇女骨强度下降的早期姿势和生物力学适应。作为矢状面排列的决定因素，SS影响骨盆方向和腰椎曲度。它的减少可能预示着重心向前移动，增加跌倒的风险。将SS评估纳入标准成像可能有助于早期识别高危个体。需要前瞻性研究来证实其临床相关性和对骨折和功能衰退的预测价值。

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引用次数: 0

Proceedings of the 2025 Santa Fe Bone Symposium: Current concepts in the care of patients with osteoporosis, parathyroid disorders, and rare bone diseases 2025年圣达菲骨研讨会论文集：骨质疏松症、甲状旁腺疾病和罕见骨疾病患者护理的当前概念

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-09-23 DOI: 10.1016/j.jocd.2025.101628

E. Michael Lewiecki , Robert A. Adler , Paul A. Anderson , John P. Bilezikian , David W. Dempster , Pouneh K. Fazeli , Michael R. McClung , Eric T. Rush , Christine M. Swanson , S. Bobo Tanner

The 2025 Santa Fe Bone Symposium (SFBS) was a combined in-person and virtual “hybrid” meeting based in Santa Fe, New Mexico, USA, on August 8-9, 2025. There were an equivalent number of in-person and remote attendees from throughout the USA and other countries. The SFBS was immediately preceded, on August 6-7, 2025, by the 2-day Endocrine Fellows Foundation-Santa Fe Bone Symposium Workshop on Metabolic Bone Diseases. This preceptorship included basic bone biology, osteoporosis, parathyroid and rare bone diseases. Most of the fellows attended the SFBS, for a total of 4 days of non-stop education in skeletal health. The topics covered at the SFBS included controversies and consensus in the use of dual-energy X-ray absorptiometry; management of osteoporosis medication side-effects; lessons learned from bone biopsies; osteoporosis in men and premenopausal women; update on treatment of rare bone diseases; parathyroid hormone and skeletal health; periprosthetic fractures; update on Bone Health ECHO; and much more. Ancillary events addressed issues such as bone health through the menopause transition, hypophosphatasia, X-linked hypophosphatemia, and osteoanabolic therapy for postmenopausal women with osteoporosis. This report of the proceedings of the 2025 SFBS summarizes the highlights and clinical insights of the plenary presentations.

2025年圣达菲骨骼研讨会（SFBS）是一场面对面和虚拟“混合”会议，于2025年8月8日至9日在美国新墨西哥州圣达菲举行。来自美国和其他国家的现场和远程参会者人数相当。在SFBS之前，于2025年8月6日至7日举行了为期两天的内分泌研究员基金会-圣达菲骨代谢性骨病研讨会。本课程包括基本骨生物学，骨质疏松症，甲状旁腺和罕见骨疾病。大多数研究员参加了SFBS，总共4天不间断的骨骼健康教育。SFBS讨论的议题包括：双能x射线吸收仪的争议与共识；骨质疏松药物副作用的处理；从骨活检中吸取的教训；男性和绝经前女性骨质疏松症；罕见骨病治疗的最新情况；甲状旁腺激素与骨骼健康；periprosthetic骨折;骨骼健康回声检查的最新情况；还有更多。辅助活动包括绝经后骨质疏松症患者的骨健康、低磷血症、x连锁低磷血症和骨合成代谢治疗。这份关于2025年SFBS会议记录的报告总结了全体会议的亮点和临床见解。

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引用次数: 0

The interface of a leaky gut with neuromuscular junction degradation; implications for severe sarcopenia 伴有神经肌肉连接处退化的漏肠界面；对严重肌肉减少症的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1016/j.jocd.2025.101618

Rizwan Qaisar , Asima Karim , Tahir Muhammad , Shaea A Alkahtani , Firdos Ahmad

Introduction: A pathological increase in intestinal permeability or leaky gut is recently implicated in the pathogenesis of age-associated muscle loss, termed sarcopenia. However, the associated myotoxic effects are poorly known. We investigated the associations of a leaky gut with neuromuscular junction (NMJ) degradation in the context of severe sarcopenia and functional compromise in older adults.

Methodology: This study includes controls (n=161, age=73.4±8.5 years) and severe sarcopenic men (n=148, age=72.4±7.2 years) for measurements of plasma markers of a leaky gut (zonulin), NMJ degradation (CAF22), and bacterial load (lipopolysaccharides-binding protein; LBP). We also measured handgrip strength (HGS), gait speed, and short physical performance battery (SPPB) as sarcopenic and functional compromise markers, respectively.

Results: Severe sarcopenic patients had higher plasma zonulin, CAF22, and LBP levels and lower HGS, gait speed, and SPPB scores than controls (all p<0.05). We found significant correlations between plasma zonulin and CAF22 in controls and severe sarcopenic men (both p<0.05). The presence of severe sarcopenia and SPPB scores < 9 were associated with strengthening the correlation between zonulin and CAF22 (p<0.05). Higher plasma zonulin and CAF22 were associated with higher plasma LBP, lower HGS and gait speed, and lower SPPB scores (all p<0.05).

Conclusion: Collectively, severe sarcopenia and functional compromise due to intestinal leak may involve NMJ degradation and higher plasma bacterial load. Future studies should establish the causal and mechanistic associations between intestinal leak and sarcopenia in old age.

导读：肠通透性或漏肠的病理增加最近与年龄相关的肌肉损失的发病机制有关，称为肌肉减少症。然而，相关的肌毒性作用尚不清楚。我们研究了在老年人严重肌肉减少症和功能损害的情况下，漏肠与神经肌肉接头（NMJ）退化的关系。方法：本研究纳入对照组（n=161，年龄=73.4±8.5岁）和重度肌少症男性（n=148，年龄=72.4±7.2岁），测量漏肠血浆标志物（zonulin）、NMJ降解（CAF22）和细菌负荷(脂多糖结合蛋白；LBP)。我们还分别测量了握力（HGS）、步态速度和短物理性能电池（SPPB）作为肌肉减少和功能损害的标志。结果：重度肌少症患者血浆zonulin、CAF22和LBP水平高于对照组，HGS、步态速度和SPPB评分低于对照组（p < 0.05）。我们发现血浆zonulin和CAF22在对照组和严重肌少症男性中存在显著相关性（p < 0.05）。存在严重的肌肉减少症和SPPB评分<；9例与zonulin与CAF22相关性增强相关（p < 0.05）。较高的血浆zonulin和CAF22与较高的血浆LBP、较低的HGS和步态速度以及较低的SPPB评分相关（均p < 0.05）。结论：肠道渗漏引起的严重肌肉减少症和功能损害可能与NMJ降解和血浆细菌负荷升高有关。未来的研究应该建立肠道渗漏和老年肌肉减少症之间的因果关系和机制联系。

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引用次数: 0

Diagnostic accuracy of axial and sagittal CT measurements for osteoporosis: A multi-vertebra evaluation 轴位和矢状位CT测量对骨质疏松症的诊断准确性：多椎体评估

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-06-02 DOI: 10.1016/j.jocd.2025.101596

Sevde Nur Emir, Ahmet Kürşat Soydan, Safiye Sanem Dereli Bulut

Background: This study aims to assess the diagnostic accuracy of axial and sagittal CT-derived Hounsfield Unit (HU) values in identifying osteopenia and osteoporosis. Additionally, it investigates whether the combination of multiple vertebral levels enhances predictive performance compared to single-level assessments.

Methodology: This retrospective study included 346 patients from who underwent both dual-energy X-ray absorptiometry (DXA) and non-contrast thoracic computed tomography (CT) scans within a 6-month interval. Axial and sagittal HU measurements were obtained from key vertebral levels, including T4, T7, T10, T12, and L1. Logistic regression and receiver operating characteristic (ROC) analyses were performed to evaluate the diagnostic performance of individual and combined vertebral models. Patients with vertebral metastases, hemangiomas, compression fractures, or severe deformities were excluded.

Results: The sagittal T4 vertebra measurement achieved the highest individual AUC (0.810), indicating strong diagnostic potential. Combining T4 and L1 measurements improved the AUC to 0.828, while a six-vertebra model yielded a slightly higher AUC of 0.844. Despite this marginal improvement, simpler two-vertebra models offer practical advantages in clinical settings. Optimal cut-off values were determined using Youden’s Index, with T4S at 164 HU and L1S at 133 HU, both showing high specificity but moderate sensitivity.

Conclusions: Axial and sagittal CT measurements, particularly at T4 and L1 levels, demonstrate strong potential for diagnosing osteopenia and osteoporosis. Combining multiple vertebral levels offers improved predictive accuracy, although simpler models remain effective. Opportunistic CT screening, utilizing scans performed for other clinical purposes, provides a practical and cost-effective alternative to DXA, enabling early intervention and comprehensive osteoporosis management.

背景：本研究旨在评估轴向和矢状位ct衍生的Hounsfield Unit （HU）值在识别骨质减少和骨质疏松症中的诊断准确性。此外，它还研究了与单水平评估相比，多个椎体水平的组合是否能提高预测性能。方法：这项回顾性研究包括346名患者，他们在6个月内接受了双能x线吸收仪（DXA）和胸部非对比计算机断层扫描（CT）扫描。轴向和矢状面HU测量来自关键椎体水平，包括T4、T7、T10、T12和L1。采用Logistic回归和受试者工作特征（ROC）分析来评估单个和联合椎体模型的诊断性能。排除有椎体转移、血管瘤、压缩性骨折或严重畸形的患者。结果：矢状面T4椎体测量个体AUC最高（0.810），具有较强的诊断潜力。结合T4和L1测量使AUC提高到0.828，而六椎体模型的AUC略高，为0.844。尽管有这种微小的改进，但更简单的双椎体模型在临床环境中具有实际优势。使用约登指数确定最佳临界值，T4S为164 HU， L1S为133 HU，均具有高特异性，但敏感性中等。结论：轴位和矢状位CT测量，特别是T4和L1水平，显示出诊断骨质减少和骨质疏松症的强大潜力。虽然简单的模型仍然有效，但结合多个椎体水平可以提高预测准确性。机会性CT筛查，利用其他临床目的的扫描，为DXA提供了实用和经济的替代方案，实现了早期干预和全面的骨质疏松症管理。

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引用次数: 0

Relationships between physical activity and bone mineral content and lean mass in Mexican adolescents 墨西哥青少年体力活动与骨矿物质含量和瘦体重的关系。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1016/j.jocd.2025.101619

Edgar Denova-Gutiérrez , Desiree López-González , Patricia Clark , Paloma Muñoz-Aguirre , Ricardo Francisco Capozza , Jose Luis Ferretti , Gustavo Roberto Cointry

Introduction/Background: The acquisition and maintenance of bone and lean mass health are significantly influenced by the mechanical environment of the skeleton, with physical activity emerging as an important factor. Our hypothesis proposes that high-impact physical activity improves bone mineral content and lean mass relationship in healthy adolescents depending on gender, pubertal maturity and skeletal location.

Methodology: We assessed the relation between bone mineral content, and lean mass in whole-body and limbs and leisure-time physical activity in Mexican children and adolescents. We conducted an analysis using data from the “Reference values of body composition in Mexican children and adolescents’ study”, which is a population-based, cross-sectional study. Using standardized protocols, Lunar iDXA instrumentation was used to measure whole-body bone mineral content and lean mass. Using a validated questionnaire, adapted for the Mexican population, the leisure-time physical activity level and the “inactive” condition were determined. ANOVA test was conducted to evaluate curve fitness and produce best-fit equations. Additionally, we used ANCOVA test to evaluate the differences between slopes and intercepts of the curves.

Results: All relationships between bone mineral content and lean mass across various regions were highly significant for all Tanner stages (P < 0.001), irrespective of the type of physical activity. Examining all regions (whole-body bone mineral content vs. whole-body lean mass and lower limbs bone mineral content and lean mass, and upper limbs bone mineral content and lean mass) intercepts were significantly higher in Tanner stage 3-5 compared to Tanner stage 1-2 for both genders (P < 0.001).

Conclusion: These results underscore the nuanced impact of leisure-time physical activity and Tanner stage on the observed relationships, suggesting potential benefits of engaging in specific physical activities during adolescence for bone health during the later stages of puberty.

介绍/背景：骨骼的机械环境显著影响骨骼和瘦骨量健康的获得和维持，其中体力活动是一个重要因素。我们的假设提出，高强度的体育活动可以改善健康青少年的骨矿物质含量和瘦质量关系，这取决于性别、青春期成熟度和骨骼位置。方法：我们评估了墨西哥儿童和青少年的骨矿物质含量、全身和四肢瘦质量与闲暇时间体育活动之间的关系。我们使用来自“墨西哥儿童和青少年身体成分参考值研究”的数据进行了分析，这是一项基于人群的横断面研究。采用标准化方案，使用Lunar iDXA仪器测量全身骨矿物质含量和瘦质量。使用一份适用于墨西哥人口的有效问卷，确定了休闲时间的身体活动水平和“不活跃”状态。采用方差分析（ANOVA）检验评价曲线的拟合性，得出最优拟合方程。此外，我们使用ANCOVA检验来评估曲线的斜率和截距之间的差异。结果：骨矿物质含量和瘦体重之间的所有关系在不同地区的所有Tanner阶段都非常显著(P 结论：这些结果强调了休闲时间体育活动和Tanner阶段对观察到的关系的细微影响，表明在青春期后期从事特定的体育活动对骨骼健康有潜在的好处。

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引用次数: 0

Correlation of Gastrocnemius Muscle Quality With Balance, Appendicular Skeletal Mass, and Fall Risk in Osteoporotic Women: A Musculoskeletal Sonography Assessment During Rest and Activity 骨质疏松女性腓肠肌质量与平衡、尾骨质量和跌倒风险的相关性：休息和活动期间的肌肉骨骼超声评估。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-10-01 Epub Date: 2025-10-09 DOI: 10.1016/j.jocd.2025.101633

Elham Bagheri Yekta , Giti Torkaman , Leila Aghaghazvini

Objectives: The weakening of the musculoskeletal system in women suffering from osteoporosis often leads to an increased risk of falls. We delved into the relationship between the echo intensity (EI) of the resting and contracting medial gastrocnemius muscle (MG) and its correlation with postural sway, appendicular skeletal muscle mass index (ASMI), and the fall efficacy scale (FES) in women over 60 diagnosed with osteoporosis.

Methods: This observational-analytical study welcomed the voluntary participation of 40 women diagnosed with osteoporosis. We employed DEXA to assess ASMI, leg fat/lean-mass, and musculoskeletal sonography to measure muscle architecture and the EI of the MG muscle during both rest and activity. We determined the center of pressure sway (CoP) in the anteroposterior (AP) and mediolateral (ML) directions during the double stance position.

Results: A significant positive correlation was observed between the EI during rest and contraction with FES (r=0.527 and 0.570, respectively). An inverse correlation was noted between MG-activation EI and ASMI (r=-0.486). Interestingly, the MG-activation EI emerged as the best predictor for the sway velocity AP and ML (R²=22 % and 23 %, respectively), and sway average amplitude ML (R²=24 %).

Conclusion: It was found that gastrocnemius muscle EI during rest and activity was associated with AP/ML postural sway, ASMI, leg fat/lean-mass and FES. MG-EI, especially during activation, could be considered as a promising noninvasive marker of muscle quality with a significant association with CoP sway and fall risk in women with osteoporosis at screening.

目的：骨质疏松症女性肌肉骨骼系统的衰弱往往导致跌倒的风险增加。我们探讨了60岁以上骨质疏松症女性静息和收缩腓肠肌内侧肌（MG）回声强度（EI）与体位摇摆、阑尾骨骼肌质量指数（ASMI）和跌倒疗效量表（FES）的关系。方法：本观察分析研究欢迎40名诊断为骨质疏松症的妇女自愿参加。我们使用DEXA评估ASMI，腿部脂肪/瘦质量，肌肉骨骼超声测量肌肉结构和MG肌在休息和活动期间的EI。我们测定了双站位时前后（AP）和中外侧（ML）方向的压力摇摆中心（CoP）。结果：休息和收缩时的EI与FES呈显著正相关（r分别为0.527和0.570）。mg活化EI与ASMI呈负相关（r=-0.486）。有趣的是，mg激活的EI是摇摆速度AP和ML （R2分别为22%和23%）和摇摆平均振幅ML （R2= 24%）的最佳预测因子。结论：休息和活动时腓肠肌EI与AP/ML姿势摆动、ASMI、腿脂/瘦质量和FES有关。MG-EI，特别是在激活期间，可以被认为是一种有希望的无创肌肉质量标志物，与骨质疏松症女性筛查时的CoP摇摆和跌倒风险有显著关联。

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