Journal of Clinical Densitometry最新文献_第6页

Effect of Radiation Therapy on CT Attenuation of Bone in Patients with Anorectal Cancer Treated with Chemotherapy 放疗对化疗肛肠癌患者骨CT衰减的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-06-11 DOI: 10.1016/j.jocd.2025.101597

Gary K. Schneider , Jason A. Benedict , Jennifer Matsui , Gavin Wu , Michael Ruesch , Rahul Prasad , Pannaga Malalur , Vedat Yildiz , Eric Miller , Steven W. Ing

Radiation therapy (RT), a standard treatment modality for locally advanced anorectal cancer, may be followed by pelvic fractures, but there are currently no formal recommendations to evaluate bone health prior to RT. Recent studies have demonstrated CT attenuation measurement of lumbar vertebrae as a surrogate marker of bone mineral density (BMD). In this single-institution retrospective cohort analysis of patients with anorectal carcinoma treated with RT, we assess lumbar and sacral CT attenuation before and after RT. CT scans of 302 patients with at least one pre- and post- RT CT scan including all of L1, L3, L5, and sacrum were reviewed, and CT attenuation measured at each level. All CT scans were obtained for either cancer surveillance or other medically indicated reason. CT attenuation measurements were adjusted for presence of IV contrast and nonstandard CT tube voltage. Prior to RT, mean bone attenuation at L1, L3, L5, and sacrum were 158.4, 151.1, 157.8, and 231.0 HU respectively. Three months post-RT, L1 and L3 had mean differences of +1.7 (+1.1 %) and −7.7 (−5.1 %) HU, respectively, while L5 and sacrum had mean differences of −48.8 (−31.0 %) and −65.9 (−28.6 %) HU, respectively. There was little to no evidence of further decrease at any vertebral level beyond three months after RT, nor was there evidence for increase in HU beyond three months, by which time RT courses were completed. This suggests that bone loss from RT is associated with proximity to the radiation field and the majority of the observed decline occurs within the first three months following the start of RT.

放射治疗（RT）是局部晚期肛管直肠癌的标准治疗方式，可能会在盆腔骨折之后进行，但目前没有正式的建议在放疗之前评估骨骼健康。最近的研究表明，腰椎CT衰减测量可以作为骨矿物质密度（BMD）的替代指标。在这项单机构回顾性队列分析中，我们评估了接受RT治疗的肛肠癌患者在RT前后的腰椎和骶骨CT衰减。我们回顾了302例患者的CT扫描，这些患者至少进行了一次RT前后的CT扫描，包括L1、L3、L5和骶骨，并测量了每个级别的CT衰减。所有的CT扫描都是为了癌症监测或其他医学上的原因。根据静脉造影剂和非标准CT管电压的存在调整CT衰减测量。放疗前，L1、L3、L5和骶骨的平均骨衰减分别为158.4、151.1、157.8和231.0 HU。术后3个月，L1和L3的平均差异分别为+1.7（+1.1 %）和- 7.7(- 5.1 %)HU， L5和骶骨的平均差异分别为- 48.8（- 31.0 %）和- 65.9(- 28.6 %)HU。在放疗后3个月后，几乎没有证据表明任何椎体水平进一步下降，也没有证据表明3个月后HU增加，到那时放疗课程完成。这表明放射治疗导致的骨质流失与靠近放射场有关，大部分观察到的骨质流失发生在放射治疗开始后的前三个月内。

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引用次数: 0

Periprosthetic Bone Mineral Density Change after Total Knee Arthroplasty in Vietnamese Population 越南人口全膝关节置换术后假体周围骨矿物质密度的变化

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-03-22 DOI: 10.1016/j.jocd.2025.101583

Hoc Nguyen Van , Khanh Nguyen Manh , Hoang Le Xuan

Objectives: After total knee arthroplasty (TKA), bone structure changes around prosthetics gradually appear. Adverse changes, such as decreased bone mineral density (BMD) and bone remodeling, can lead to joint loosening, affecting surgical outcomes. The study aims to detect BMD changes in the bone around the artificial knee early after TKA.

Methods: We performed a prospectively descriptive study on 54 patients who were operated at Viet Duc University Hospital from 4/2017 to 4/2019. Bone density was measured using dual-energy X-ray absorptiometry (DEXA) at the seventh days, 3,6,12, and 24 months post-surgery.

Results: The BMD in the medial metaphyseal region of interest decreased by 10.36 %, 11.5 %, 11.88 %, and 12.13 % at 3, 6, 12, and 24 months respectively, compared to 7 days post-surgery. The lateral metaphyseal region of interest decreased by 6.09 %, 6.47 %, 6.97 %, and 7.1 % and the tibial diaphyseal region of interest decreased by 3.75 %, 4.66 %, 5.91 %, and 5.8 % over the same follow-up periods. The BMD in the femoral condyle region of interest decreased by 8.15 %, 8.62 %, 9.24 %, and 10.65 % compared to the corresponding 7-day period at 3,6,12, and 24 months post-surgery.

Conclusion: The periprosthetic BMD rapidly reduced in the first 3 months, then gradually decreased. After 24 months of follow-up, the BMD in the medial metaphyseal region of interest decreased the most.

目的：全膝关节置换术后，假体周围骨结构的变化逐渐显现。不利的变化，如骨密度（BMD）降低和骨重塑，可导致关节松动，影响手术结果。本研究旨在检测膝关节置换术后早期人工膝关节周围骨的骨密度变化。方法：对2017年4月至2019年4月在越南大学医院手术的54例患者进行前瞻性描述性研究。术后第7天、3、6、12、24个月采用双能x线骨密度仪（DEXA）测量骨密度。结果：与术后7天相比，内侧干骺端感兴趣区骨密度在术后3、6、12和24个月分别下降了10.36 %、11.5 %、11.88 %和12.13 %。在相同的随访期间，外侧干骺端感兴趣区分别减少了6.09 %、6.47 %、6.97 %和7.1 %，胫骨干骺端感兴趣区分别减少了3.75 %、4.66 %、5.91 %和5.8 %。与术后3、6、12和24个月相应的7天时间相比，股骨髁感兴趣区域的BMD分别下降了8.15% %、8.62% %、9.24% %和10.65 %。结论：假体周围骨密度在前3个月迅速下降，随后逐渐下降。随访24个月后，内侧干骺端感兴趣区域的骨密度下降最多。

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引用次数: 0

Sprinting performance correlates with composite indices of femoral neck strength in middle-aged active men 中年运动男性短跑成绩与股骨颈力量综合指标相关

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-04-04 DOI: 10.1016/j.jocd.2025.101586

Ibrahim Fayad , Antonio Pinti , Hassane Zouhal , Rawad El Hage

The aim of the current study was to explore the relationships between 20-meter sprinting time and composite indices of femoral neck strength (compression strength index (CSI), bending strength index (BSI) and impact strength index (ISI)) in a group of middle-aged active men. 50 middle-aged active men voluntarily participated in this study. Their mean age was 45 ± 8.6 years. Body composition, total hip bone mineral density (TH BMD) and femoral neck bone mineral density (FN BMD) were evaluated by DXA. Sprinting time was negatively correlated to CSI (r = −0.52; p < 0.001), BSI (r = −0.43; p < 0.01) and ISI (r = −0.47; p < 0.001). The significant correlations between sprinting time and composite indices of femoral neck strength (CSI, BSI and ISI) remained significant after controlling for body weight, age and maximum oxygen consumption using multiple linear regressions. In conclusion, the current study suggests that sprinting performance (m/sec) is a positive determinant of CSI, BSI and ISI in middle-aged men.

本研究旨在探讨 20 米短跑时间与股骨颈强度综合指数（压缩强度指数（CSI）、弯曲强度指数（BSI）和冲击强度指数（ISI））之间的关系。50 名中年男性运动员自愿参加了此次研究。他们的平均年龄为 45 ± 8.6 岁。通过 DXA 评估了身体成分、全髋骨矿物质密度（TH BMD）和股骨颈骨矿物质密度（FN BMD）。短跑时间与 CSI（r = -0.52；p <；0.001）、BSI（r = -0.43；p <；0.01）和 ISI（r = -0.47；p <；0.001）呈负相关。在使用多重线性回归控制体重、年龄和最大耗氧量后，短跑时间与股骨颈力量综合指数（CSI、BSI 和 ISI）之间的显着相关性仍然显着。总之，本研究表明，短跑成绩（米/秒）对中年男性的 CSI、BSI 和 ISI 有积极的决定作用。

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引用次数: 0

Pediatric Lateral Distal Femur Reference Ranges for Ages 1 to 18 years 1至18岁儿童股骨外侧远端参考范围

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-05-07 DOI: 10.1016/j.jocd.2025.101594

Babette S. Zemel , John A. Shepherd , Laila Kazemi , Andrea Kelly , Virginia A. Stallings , Heidi Kecskemethy , David R. Weber , Halley Wasserman , Heidi J. Kalkwarf

Introduction: Many children with musculoskeletal disorders are at high risk of fracture, and the lateral distal femur (LDF) may be the only feasible site to measure bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA). Pediatric reference ranges and adjustment for linear growth are needed to interpret BMD results.

Methods: Lateral distal femur scans by DXA were obtained on children, ages 1 to 18 y, from two clinical centers. Precision in young children was estimated from duplicate scans. Smoothed reference ranges for three regions of the LDF were generated. Prediction equations were developed to account for the effects of short or tall stature on BMD.

Results: We obtained >2400 measurements on 1,245 children and generated reference ranges for three LDF BMD regions. Precision of BMD was similar (% CV of 1.33 to 2.42 %) to estimates reported at other skeletal sites. Modest sex differences were observed, with females having greater BMD than males at older ages. Children identified as Black had greater BMD than children identified as Non-Black. Height-for-age Z-scores were associated with BMD-for-age Z-scores in pre- and peri-pubertal children, and adjustment equations were generated.

Conclusions: This study fills substantial gaps in pediatric bone health assessment for children with musculoskeletal disorders who are at high-risk of fracture by providing smoothed reference ranges for ages 1 to 18 y and equations to estimate the impact of small body size on BMD-for-age Z-scores.

导读：许多患有肌肉骨骼疾病的儿童骨折风险高，股骨外侧远端（LDF）可能是双能x线骨密度仪（DXA）测量骨矿物质密度（BMD）的唯一可行部位。需要儿童参考范围和线性生长调整来解释骨密度结果。方法：通过DXA对来自两个临床中心的1至18岁的儿童进行外侧股骨远端扫描。通过重复扫描估计幼儿的精确度。生成了LDF的三个区域的平滑参考范围。开发了预测方程来解释矮或高的身材对骨密度的影响。结果：我们对1245名儿童进行了2400次测量，并生成了三个LDF BMD区域的参考范围。BMD的精度与其他骨骼部位的估计相似（% CV为1.33至2.42 %）。观察到适度的性别差异，老年女性的骨密度高于男性。黑人儿童的骨密度高于非黑人儿童。在青春期前和青春期周围儿童中，身高年龄z分数与骨密度年龄z分数相关，并生成调整方程。结论：本研究通过提供1 - 18岁的平滑参考范围和估算小体型对年龄骨密度z分数影响的方程，填补了骨折高危肌肉骨骼疾病儿童骨骼健康评估的实质性空白。

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引用次数: 0

Comparison of Body Composition Estimates in Hispanic Women by Dual-Energy X-ray Absorptiometry and Hydrostatic Densitometry 用双能x线吸收仪和静压密度仪估算西班牙裔妇女身体成分的比较

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1016/j.jocd.2025.101595

Sarah E. Deemer , Diana E. Kolb , Nicole L. Cipriano , Daniel L. Smith , George A. King

Introduction: Accurate assessment of body composition is critical for understanding health risks and developing appropriate interventions, particularly in underrepresented populations. The purpose of this study was to compare the body composition estimate (% body fat [%BF]) between dual-energy x-ray absorptiometry (DXA) and hydrodensitometry via hydrostatic weighing (HW) in a group of Hispanic pre-menopausal women.

Methodology: Healthy Hispanic women (n=78, age: 22–51 years, BMI: 18.5–42.5) were measured for body composition by DXA and HW at a single lab visit. %BF from HW was calculated from body density using three commonly used adult-specific equations (2-component [2-C] Siri, 2-C Brozek, 3-component [3-C] Lohman) and a 2-C Hispanic-specific equation. Comparisons between the two methods (DXA and HW) were analyzed using paired t-tests, and linear regression and Bland-Altman plots were used to assess agreement between the two methods.

Results: %BF was significantly higher by DXA compared to all four HW equations (P < 0.01). Based on regression analyses the mean difference scores were not different from zero for all estimates of %BF.

Conclusions: While DXA and HW are both common laboratory measures for determining %BF, given the time-efficiency, minimal participant effort, and high precision, %BF estimation by DXA appears to be an adequate and sufficient method of measurement of body composition in Hispanic women.

引言：准确评估身体成分对于了解健康风险和制定适当的干预措施至关重要，特别是在代表性不足的人群中。本研究的目的是比较一组西班牙裔绝经前妇女双能x线吸收仪（DXA）和液体静力称重（HW）的体成分估计值（体脂% [%BF]）。方法：健康的西班牙裔女性（n=78，年龄：22-51岁，BMI: 18.5-42.5）在单次实验室访问时通过DXA和HW测量身体成分。根据体密度，采用三种常用的成人特异性方程（2组分[2-C] Siri， 2组分[2-C] Brozek， 3组分[3-C] Lohman）和2组分[3-C]西班牙裔特异性方程计算BF %。使用配对t检验分析两种方法（DXA和HW）之间的比较，并使用线性回归和Bland-Altman图来评估两种方法之间的一致性。结果：与所有四种HW方程相比，DXA显著提高了BF % (P <；0.01)。基于回归分析，对于所有%BF的估计，平均差异分数与零没有差异。结论：虽然DXA和HW都是确定%BF的常用实验室测量方法，但考虑到时间效率、最小的参与者努力和高精度，DXA估计%BF似乎是西班牙裔女性身体成分测量的适当和充分的方法。

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引用次数: 0

Correlation of Lean Mass Measurements Between a Novel Whole-body X-ray Bone Densitometer (iNSiGHT C510) and Magnetic Resonance Imaging: A Single-center Comparative study 新型全身x线骨密度仪（iNSiGHT C510）与磁共振成像之间瘦质量测量的相关性：单中心比较研究

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-03-26 DOI: 10.1016/j.jocd.2025.101585

Yong-Chan Ha , Shinjune Kim , Jun-Il Yoo

Background: Sarcopenia, the age-related loss of muscle mass, increases health risks in older adults. Accurate measurement of skeletal muscle mass is critical for diagnosis. While DEXA is widely used, its extended scan time limits clinical utility. This study evaluates the accuracy of lean mass measurements from the newly developed iNSiGHT C510 X-ray bone densitometer compared to MRI, the gold standard.

Methods: This single-center, open-label clinical trial included 20 adult participants (10 males, 10 females) aged 20–70 years. Participants underwent whole-body scans using the iNSiGHT C510 and MRI. Lean and fat mass measurements were obtained from both devices. Statistical analysis included Bland-Altman plots, intraclass correlation coefficients (ICC), and concordance correlation coefficients (CCC) to assess agreement between the two methods. Linear regression analysis was performed to derive conversion formulas between C510 and MRI measurements.

Results: The study found a very strong correlation between lean mass measurements from the iNSiGHT C510 and MRI, with correlation coefficients (r) of 0.961 for the right side, 0.967 for the left, and 0.963 for combined lean mass. ICC and CCC values for lean mass were also high, indicating strong agreement between the two methods. Fat mass measurements, though moderately correlated, showed larger discrepancies compared to lean mass. The iNSiGHT C510 significantly reduced measurement time by 50 % compared to conventional DEXA scans.

Conclusion: The iNSiGHT C510 demonstrated high accuracy in measuring lean mass compared to MRI, with the added benefit of shorter measurement time, making it a practical tool for sarcopenia diagnosis and monitoring in clinical settings. However, further research with larger sample sizes and long-term assessments is needed to validate its broader clinical utility.

背景：骨骼肌减少症，与年龄相关的肌肉质量损失，增加了老年人的健康风险。准确测量骨骼肌质量对诊断至关重要。虽然DEXA被广泛使用，但其延长的扫描时间限制了临床应用。本研究评估了新开发的iNSiGHT C510 x射线骨密度仪与MRI（金标准）相比的瘦质量测量的准确性。方法：这项单中心、开放标签的临床试验包括20名年龄在20 - 70岁之间的成人受试者（10男10女）。参与者使用iNSiGHT C510和MRI进行全身扫描。从这两种设备中获得了瘦和脂肪质量测量值。统计分析包括Bland-Altman图、类内相关系数（ICC）和一致性相关系数（CCC）来评估两种方法之间的一致性。进行线性回归分析，得出C510与MRI测量值之间的转换公式。结果：研究发现iNSiGHT C510测量的瘦质量与MRI之间存在很强的相关性，右侧的相关系数(r)为0.961，左侧为0.967，综合瘦质量为0.963。瘦质量的ICC和CCC值也很高，表明两种方法之间的一致性很强。脂肪质量测量虽然有一定的相关性，但与瘦质量相比，差异更大。与传统的DEXA扫描相比，iNSiGHT C510显着减少了50%的测量时间。结论：与MRI相比，iNSiGHT C510在测量瘦质量方面具有较高的准确性，并且测量时间更短，使其成为临床诊断和监测肌肉减少症的实用工具。然而，需要更大样本量的进一步研究和长期评估来验证其更广泛的临床应用。

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引用次数: 0

An Examination of Patient Knowledge and Education in Patients with Osteoporosis, Osteopenia, and Normal Bone Density 骨质疏松症、骨质减少症和正常骨密度患者的知识和教育检查

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-03-19 DOI: 10.1016/j.jocd.2025.101578

Ahdad Ziyar , Alexander Bolufer , Emily Littman , Shazia Beg

Introduction: Osteoporosis represents a preventable and often treatable condition that is responsible for 1.5 million fractures annually in the United States. Proper patient knowledge represents a crucial aspect of disease management and has potential implications in treatment adherence and lifestyle modification. By examining how much patients know about their own diagnosis, their disease knowledge, and what resources they would like to use, we aim to lay the groundwork for developing efficient patient education resources. Methodology: We surveyed 52 individuals and collected data on demographics, bone density test results, disease knowledge, and educational sources both used and preferred. This was done to learn how much patients know about their condition on a fundamental level. Results: 50% of participants diagnosed with osteoporosis correctly self-reported their condition, as did 21.1% diagnosed with osteopenia. Between the normal, osteopenia, and osteoporosis groups there were no significant differences between participants’ scores on the patient knowledge questionnaire. The resources most used by patients were handouts/brochures and internet/personal research, and patients reported a preference for learning directly from their doctor/nurse. Conclusion: Osteoporosis is associated with millions of fragility fractures occurring annually worldwide. Our study showed a consistent level of knowledge across patients with normal bone mineral density, osteopenia, and osteoporosis, suggesting the need for targeted education efforts, particularly for those with severe forms of the disease. We confirmed the invaluable role of medical personnel in teaching patients about bone density loss. It is through efficient learning that patients can be empowered to take charge of their health.

骨质疏松症是一种可预防且通常可治疗的疾病，每年在美国造成150万例骨折。适当的患者知识代表了疾病管理的一个关键方面，并对治疗依从性和生活方式的改变具有潜在的影响。通过检查患者对自己的诊断、疾病知识的了解程度，以及他们想要使用的资源，我们的目标是为开发有效的患者教育资源奠定基础。方法：我们调查了52个人，收集了人口统计学、骨密度测试结果、疾病知识和常用和首选的教育来源的数据。这样做是为了了解患者在基本层面上对自己的病情了解多少。结果：50%被诊断为骨质疏松的参与者正确地自我报告了他们的病情，21.1%被诊断为骨质减少。在正常组、骨质疏松组和骨质疏松组之间，参与者在患者知识问卷上的得分没有显著差异。患者使用最多的资源是讲义/小册子和互联网/个人研究，患者报告更倾向于直接从他们的医生/护士那里学习。结论：骨质疏松症与全球每年发生的数百万例脆性骨折有关。我们的研究显示，正常骨密度、骨质减少和骨质疏松患者的知识水平是一致的，这表明有必要进行有针对性的教育，特别是对那些患有严重疾病的患者。我们证实了医务人员在教导患者骨密度损失方面的宝贵作用。只有通过有效的学习，病人才能掌握自己的健康。

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引用次数: 0

Bone Mineral Density and Associated Factors in Individuals with Traumatic Unilateral Transfemoral Amputation 外伤性单侧经股截肢患者的骨密度及其相关因素

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-06-03 DOI: 10.1016/j.jocd.2025.101598

Gizem Kılınç Kamacı, Merve Örücü Atar, Elif Tekin, Fatma Özcan, Yasin Demir, Koray Aydemir

Introduction/background: Lower extremity amputations, particularly at more proximal levels such as transfemoral amputations (TFA)s, negatively affect bone mineral density (BMD). The aim of this study was to determine the relationship between muscle strength, residual limb length (RLL), and BMD on the amputated side in individuals with traumatic unilateral TFA and to investigate other potentially related factors.

Methodology: This is a retrospective, cross-sectional study. The study included 39 individuals with TFA. Demographic and clinical data of the individuals were recorded. RLL was determined by measuring the distance from the trochanter major to the most distal end point of the stump. Hip flexor and extensor muscle strengths were assessed by determining peak torque at an angular velocity of 60°/s using an isokinetic system. Dual-energy X-ray absorptiometry (DXA) imaging T-scores of the femoral neck and lumbar spine on the amputee side were evaluated.

Results: There was a statistically significant relationship between peak hip flexion torque and RLL with the femoral neck BMD T-score (r = 0.327*, p = 0.045; r = 0.432*, p = 0.006, respectively). RLL and peak hip flexion torque were identified as determinants of femoral neck BMD T-score (p = 0.004, p = 0.031, respectively). It was found that for every 1 cm increase in RLL, the femoral neck BMD T-score increased by approximately 0.09. A one-unit increase in peak hip flexion torque was associated with an approximate increase of 0.04 in the ipsilateral femoral neck BMD T-score.

Conclusions: In the rehabilitation program of individuals with unilateral TFA, it may be important to plan hip flexor muscle strengthening interventions that may affect BMD. Performing amputation surgeries while preserving RLL at the longest possible length may be beneficial in terms of BMD results on the amputated side.

介绍/背景：下肢截肢，特别是近端截肢，如经股截肢（TFA），对骨密度（BMD）有负面影响。本研究的目的是确定外伤性单侧TFA患者截肢侧肌肉力量、残肢长度（RLL）和骨密度之间的关系，并探讨其他潜在的相关因素。方法：这是一项回顾性的横断面研究。该研究包括39名TFA患者。记录患者的人口学和临床资料。RLL是通过测量从大转子到残端最远端点的距离来确定的。通过等速系统测定60°/s角速度下的峰值扭矩来评估髋屈肌和伸肌力量。评估截肢侧股骨颈和腰椎双能x线吸收仪（DXA）成像t评分。结果：髋峰值屈曲力矩、RLL与股骨颈BMD t -评分有统计学意义(r = 0.327*,p = 0.045；R = 0.432*,p = 0.006)。RLL和髋峰值屈曲力矩被确定为股骨颈BMD t评分的决定因素（p = 0.004,p = 0.031）。研究发现，RLL每增加1 cm，股骨颈BMD t评分增加约0.09。峰值髋关节屈曲扭矩每增加一个单位，同侧股骨颈BMD t评分约增加0.04。结论：在单侧TFA患者的康复计划中，制定可能影响BMD的髋屈肌强化干预措施可能很重要。在进行截肢手术的同时尽可能长地保留RLL，对于截肢侧的骨密度结果可能是有益的。

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引用次数: 0

The role of trunk region body composition in lumbar spine bone mineral content and density 躯干区域体成分对腰椎骨矿物质含量和密度的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-03-10 DOI: 10.1016/j.jocd.2025.101580

Mohammad Reza Foroutani , Mohammad Reza Salamat , Sakineh Bagherzadeh , Mohammad Keshtkar , Mehri Khoshhali , Mahdi Asgari

Background: The aim of this study was to investigate the differential effects of trunk region body composition—specifically fat mass (FM) and lean mass (LM)—on lumbar spine bone mineral density (BMD) and bone mineral content (BMC), with a focus on variations by gender and menopausal status.

Materials and Methods: We identified 331 adult patients (69 men, 161 premenopausal women, and 101 postmenopausal women) who underwent dual-energy X-ray absorptiometry (DXA) to simultaneously measure trunk body composition and lumbar spine BMD (L₂-L₄). The Pearson correlation coefficient was used to assess the linear relationships between body composition components and lumbar spine BMD and BMC, stratified by gender and menopausal status. Additionally, multiple linear regression analysis with the forward stepwise elimination procedure was applied to find a reasonable subset of predictor variables.

Result: The highest correlation coefficients between body composition and BMD were seen for men and post- and premenopausal individuals in the following areas: pelvic fat mass (r = 0.325; P < 0.01), chest lean mass (r = 0.260; P < 0.01), and total lean mass (r = 0.312; P < 0.01), respectively. Additionally, total lean mass (r = 0.477; P < 0.01), chest lean mass (r = 0.360; P < 0.01), and total lean mass (r = 0.459; P < 0.01) had the strongest correlation coefficients between body composition and BMC. Forward stepwise regression identified age, chest lean mass, and midriff fat mass as predictors of BMC in postmenopausal women; BMI and total lean mass in premenopausal women; and total lean mass in men. For BMD, chest lean mass (postmenopausal), total lean mass (premenopausal), and BMI (men) were significant predictors.

Conclusions: Fat mass does not affect BMD or BMC, while lean mass, strongly predicts bone health. Trunk body composition showed varying relationships with BMD and BMC, making it challenging to pinpoint how lean mass distribution in the chest and midriff specifically impacts bone health.

背景：本研究的目的是探讨躯干区域身体组成（特别是脂肪量（FM）和瘦质量（LM））对腰椎骨密度（BMD）和骨矿物质含量（BMC）的差异影响，重点关注性别和绝经状态的变化。材料和方法：我们确定了331名成年患者（69名男性，161名绝经前女性和101名绝经后女性），他们接受了双能x线吸收仪（DXA），同时测量躯干成分和腰椎骨密度（L2-L4）。使用Pearson相关系数评估身体组成成分与腰椎BMD和BMC之间的线性关系，并按性别和绝经状态分层。此外，采用多元线性回归分析和正向逐步消去程序来寻找合理的预测变量子集。结果：男性、绝经后和绝经前个体的身体成分与骨密度之间的相关系数最高的区域如下：骨盆脂肪量(r = 0.325；P <； 0.01)，胸瘦质量(r = 0.260；P <； 0.01)，总瘦质量(r = 0.312；分别P & lt; 0.01)。此外，总瘦质量(r = 0.477；P <； 0.01)，胸瘦质量(r = 0.360；P <； 0.01)，总瘦体重(r = 0.459；体成分与BMC的相关系数为P <； 0.01)。前向逐步回归发现年龄、胸部瘦质量和腹部脂肪质量是绝经后妇女BMC的预测因素；绝经前妇女的身体质量指数和总瘦体重；以及男性的总瘦体重。对于骨密度，胸瘦质量（绝经后）、总瘦质量（绝经前）和BMI（男性）是显著的预测因子。结论：脂肪量不影响骨密度或BMC，而瘦质量强烈预测骨骼健康。躯干身体组成与骨密度和BMC的关系各不相同，这使得确定胸部和腹部的瘦质量分布如何具体影响骨骼健康变得具有挑战性。

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引用次数: 0

Letter to the editor: Persisting lymphangiogram contrast, A potential DXA confounder 致编辑的信：持续的淋巴管造影，潜在的DXA混淆

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 Epub Date: 2025-06-16 DOI: 10.1016/j.jocd.2025.101601

N. Binkley, A. Eastman, N. Jina, D. Krueger

引用次数: 0